WO2024063602A1

WO2024063602A1 - Gravimetry-based device for diluting and dispensing sample

Info

Publication number: WO2024063602A1
Application number: PCT/KR2023/014505
Authority: WO
Inventors: 송영철; 노예철; 김정택
Original assignee: 한국화학연구원
Priority date: 2022-09-23
Filing date: 2023-09-22
Publication date: 2024-03-28
Also published as: KR20240041502A

Abstract

An embodiment of the present invention provides a gravimetry-based device for diluting and dispensing a sample, comprising: a base part divided into a plurality of space units to perform a process of diluting and dispensing a sample in each space; a driving module including a driving arm for holding at least one sample container and moving the sample container to each space of the base part; a pump module for injecting a stock solution or feeding strong acid into the sample container; and a weight measurement module for measuring the weight of the sample container and recording the weight measurement result.

Description

Gravimetric-based sample dilution and dispensing device

The present invention relates to a sample dilution and dispensing device.

This study is related to the public infrastructure-based industrial support platform technology (No. 1711160168) of the research project conducted with the support of the Korea Research Institute of Chemical Technology with funding from the Ministry of Science and ICT (Government) in 2022.

Sample pretreatment is essential for qualitative and quantitative analysis using inductively coupled plasma atomic emission spectroscopy (ICP-AES) or mass spectrometry (ICP-MS).

The sample pretreatment process is a process to liquefy the sample. By mixing the sample with a strong acid to dissolve the analyte elements in the sample and diluting the sample with a strong acid, the concentration of the sample is adjusted to set conditions (ranging from ppm to several percent). At this time, sample dilution based on the volumetric method has a high synthetic standard uncertainty, so sample dilution based on the gravimetric method is preferable for precise analysis.

Because the sample pretreatment process involves measuring and checking the weight on a scale and manually diluting the sample, it is a process that takes more than 10 times more time than instrumental analysis and more than twice as much time as interpreting the analysis data. Additionally, the use of strong acids may expose researchers to acids or acid gases.

Meanwhile, errors resulting from errors occurring during the liquefaction and dilution process of the current sample are very large. Even in liquefied samples, depending on the choice of acid, there are cases where the analyte element cannot be dissolved, and the analyte element may vaporize.

Accordingly, researchers need technology to minimize exposure to acids and acid gases and reduce pretreatment time.

The problem to be solved according to an embodiment of the present invention is to automatically dispense and dilute samples during the pretreatment process, and in particular, to ensure safety by separating the dilution work from the researcher and the dilution of the sample based on a weight method using a precision scale. It includes promoting

The technical problem to be achieved by the present invention is not limited to the technical problem mentioned above, and other technical problems not mentioned can be clearly understood by those skilled in the art from the description below. There will be.

In order to solve the above problem, the gravimetry-based sample dilution and dispensing device according to an aspect of the present invention is divided into a plurality of space units, so that each space includes a base portion where the sample dilution and dispensing process is performed, and at least one It includes a driving arm for holding a sample container, a driving module for moving the sample container to each space of the base portion, a pump module for injecting a stock solution or weak acid into the sample container, and a weight of the sample container. It may include a weight measurement module that measures and records the weight measurement results.

In addition, it may further include a control unit that controls the operation of the driving module or generates a control message to control the pump module according to preset sample dilution conditions and dispensing order.

Here, the control unit may receive the weight measurement result from the weight measurement module and feedback control at least one of the driving module and the pump module based on the weight measurement result.

Here, the base portion includes a sample holder including a sample holder on which the sample container can be mounted, and the sample holder includes an undiluted sample line containing an undiluted solution sample and a plurality of conduits containing samples diluted by concentration. A dilution sample line may be included.

Here, the base part may include a shaker part in which the driving arm shakes the diluted solution a predetermined number of times before dispensing the stock solution or when a strong acid is added to the sample container and diluted.

Here, the driving module is connected to the driving arm and may further include a moving unit that moves the driving arm to each space of the base using at least three axes.

Here, the pump module includes a stock solution injection unit for injecting a stock solution into the sample container and a weak acid nozzle section for injecting weak acid into the sample container, and the stock solution injection section and the weak acid nozzle section respond to the control message from the control unit. Based on this, the stock solution injection unit may be opened and closed or the weak acid nozzle unit may be opened and closed.

Here, the stock solution injection unit may further include a pipette coupling portion at the bottom to which a pipette tip capable of transferring the stock solution is detachably coupled.

Here, the stock solution injection unit injects the stock solution into the sample container based on the set sample dilution conditions, and the control unit injects the stock solution when the weight measurement result reaches a preset target weight. can be controlled to stop.

Here, the strong acid nozzle unit injects the strong acid into the sample container based on the set sample dilution conditions, and the control unit, when the weight measurement result reaches the preset target weight, the strong acid nozzle unit injects the strong acid. can be controlled to stop.

As described above, according to the embodiments and various aspects of the present invention, the sample can be automatically dispensed and diluted during the pretreatment process, thereby protecting researchers from risks resulting from acid treatment work.

In addition, preprocessing time can be reduced by automatically storing the sample weight and performing automatic dispensing according to the dilution ratio.

The effects of the present invention are not limited to the effects described above, and should be understood to include all effects that can be inferred from the configuration of the invention described in the description or claims of the present invention.

Figure 1 is a diagram showing a sample dilution and dispensing device based on the gravimetric method according to an embodiment of the present invention.

Figure 2 is a block diagram showing the control unit of a gravimetry-based sample dilution and dispensing device according to an embodiment of the present invention.

Figure 3 is a diagram showing the overall configuration including a gravimetry-based sample dilution and dispensing device according to an embodiment of the present invention.

Figure 4 is a diagram showing a driving module of a gravimetry-based sample dilution and dispensing device according to an embodiment of the present invention.

Figure 5 is a diagram showing the weight measurement module of the sample dilution and dispensing device based on the gravimetric method according to an embodiment of the present invention.

Figure 6 is a diagram showing the shaker part of the sample dilution and dispensing device based on the gravimetric method according to an embodiment of the present invention.

Figure 7 is a diagram showing the nitric acid nozzle and pump module of the gravimetry-based sample dilution and dispensing device according to an embodiment of the present invention.

Figure 8 is a diagram showing the capping part of the sample dilution and dispensing device based on the gravimetric method according to an embodiment of the present invention.

Figure 9 is a diagram showing a sample holder of a weight method-based sample dilution and dispensing device according to an embodiment of the present invention.

Figure 10 is a diagram showing the pipette rack part of the gravimetry-based sample dilution and dispensing device according to an embodiment of the present invention.

Figure 11 is a diagram showing the pipette removal part of the gravimetry-based sample dilution and dispensing device according to an embodiment of the present invention.

Hereinafter, the present invention will be described with reference to the attached drawings. However, the present invention may be implemented in various different forms and, therefore, is not limited to the embodiments described herein. In order to clearly explain the present invention in the drawings, parts that are not related to the description are omitted, and similar parts are given similar reference numerals throughout the specification.

Throughout the specification, when a part is said to be "connected (connected, contacted, combined)" with another part, this means not only "directly connected" but also "indirectly connected" with another member in between. "Includes cases where it is. Additionally, when a part is said to “include” a certain component, this does not mean that other components are excluded, but that other components can be added, unless specifically stated to the contrary.

In this specification, expressions such as “A or B,” “at least one of A or/and B,” or “one or more of A or/and B” may include all possible combinations of the items listed together. . For example, “A or B,” “at least one of A and B,” or “at least one of A or B” (1) includes at least one A, (2) includes at least one B, or (3) It can refer to all cases including both at least one A and at least one B.

The terms used herein are only used to describe specific embodiments and are not intended to limit the invention. Singular expressions include plural expressions unless the context clearly dictates otherwise. In this specification, terms such as “comprise” or “have” are intended to indicate the presence of features, numbers, steps, operations, components, parts, or combinations thereof described in the specification, but are not intended to indicate the presence of one or more other features. It should be understood that this does not exclude in advance the possibility of the existence or addition of elements, numbers, steps, operations, components, parts, or combinations thereof.

Hereinafter, embodiments of the present invention will be described in detail with reference to the attached drawings.

One embodiment of the present invention relates to a gravimetric-based sample dilution and dispensing device.

Referring to FIG. 1, the gravimetry-based sample dilution and dispensing device 10 according to an embodiment of the present invention includes a base unit 100, a drive module 200, a pump module 300, and a weight measurement module 400. ) and a control unit 500.

The gravimetric-based sample dilution and dispensing device 10 according to an embodiment of the present invention preprocesses samples for qualitative and quantitative analysis using inductively coupled plasma atomic emission spectroscopy (ICP-AES) or mass spectrometry (ICP-MS). This is a device for automatically dispensing and diluting samples during the process.

The base unit 100 is divided into a plurality of space units, so that sample dilution and dispensing processes are performed in each space. The driving module 200 may move to each position of the base unit 100 according to the dispensing process and perform dilution and dispensing processes at each position.

Referring to FIG. 1, the base portion 100 of the gravimetry-based sample dilution and dispensing device 10 according to an embodiment of the present invention includes a sample holder 110, a shaker part 120, and a strong acid part 130. ), a measuring part 140, a capping/decapping part 150, a strong acid nozzle part 160, a pipette rack part 170, and a pipette removal part 180.

Figure 1 shows that the base unit 100 according to an embodiment of the present invention is divided into a plurality of spaces according to each dispensing process. The location and size of each partition are not limited to this, and the dispensing process and sequence are not limited to this. Changes are possible depending on.

As shown in FIG. 3 below, the sample holder 110 includes a sample holder 111 on which the sample container 20 can be mounted.

The sample holder 111 is intended to hold a plurality of sample containers 20, may be formed in a flat shape, and may include a sliding member to be movable in the vertical and plane directions.

In addition, the sample holder 111 includes a plurality of through holes on the inside, and the sample container 20 is inserted into the through holes.

The shaker part 120 is provided so that the driving arm shakes the diluted solution a predetermined number of times before dispensing the stock solution or when strong acid is added to the sample container and diluted.

The strong acid part 130 is provided so that the nitric acid solution is placed. The pump module 300 can be moved to the strong acid part 130 to previously contain nitric acid that can be added to the sample container of the pump module 300.

The measurement part 140 includes a weight measurement module 400 and can measure the weight of the sample container 20.

The weight measurement module 400 can measure the weight of the sample container and record the weight measurement result.

In one embodiment of the present invention, the weight measurement module 400 may be a precision scale, and the gravimetry-based sample dilution and dispensing device measures the weight of the sample container and dilutes the stock solution with a strong acid to increase the concentration of the sample solution. It can be adjusted to specified conditions (ranging from ppm to several percent).

Conventionally, pretreatment of the sample was performed by placing the sample in a graduated vial and injecting nitric acid using a pipette or syringe. Of course, most of these tasks were performed by people, and some automated devices were used. The problem is dilution based on volume. Because the volume of the liquid changes depending on the surrounding temperature, if diluted based on volume, it is difficult to accurately meet the concentration conditions of the sample.

The sample dilution and dispensing device based on the gravimetric method according to an embodiment of the present invention can accurately adjust the concentration conditions of the sample regardless of the surrounding temperature and environment by adjusting the concentration of the sample based on the gravimetric method.

The capping/decapping part 150 is provided to close or open the cap on the top of the sample container before and after the strong acid is injected into the sample container 20.

Referring to FIG. 1, the capping/decapping part 150 may be divided into a capping part 150a and a decapping part 150b.

The driving module 200 opens the cap of the sample container at the capping/decapping part 150 and moves to the strong acid nozzle part 160, which will be described later. When the strong acid is injected, it returns to the capping/decapping part 150. After moving and closing the cap of the sample container, it moves to the shaker part 120.

The strong acid nozzle part 160 is provided to be connected to a strong acid nozzle so that the pump module 300 can inject strong acid into the sample container. In one embodiment of the present invention, a nitric acid solution is used as a strong acid, but other acids may be used, and as a diluted solution, not only a nitric acid solution but also other acids, alkaline solutions, distilled water, etc. may be used.

The pipette rack part 170 is provided so that a pipette tip capable of transferring a stock solution is detachably coupled to the bottom of the pump module 300.

In one embodiment of the present invention, the stock solution may be prepared in advance in the sample holder 110, and when a pipette tip capable of transferring the stock solution is coupled to the bottom of the pump module 300, the drive module 200 uses the pipette. Thus, the stock solution can be injected into the sample container.

The pipette removal part 180 is provided to disconnect the pipette tip after the stock solution is injected into the sample container.

The driving module 200 moves the sample container to each space of the base part.

The driving module 200 includes a driving arm 210 and a moving unit 220.

The driving arm 210 may hold at least one sample container 20.

Specifically, the driving arm 210 may include a finger portion with one or more fingers, and pincer grasping and wrapping can be performed selectively or sequentially.

Accordingly, the sample container can be fixed and moved to each space of the base portion without a separate configuration for inserting the sample container.

The moving unit 220 is connected to the driving arm 210 and can move the driving arm to each space of the base using at least three axes.

The moving unit 220 may include a rail and a motor (not shown), and includes a first rail installed along the X-axis direction, a second rail installed along the Y-axis direction, and a third rail installed along the Z-axis direction. May include rails.

The driving arm 210 can move to each space of the base along the rail by driving a motor (not shown).

According to one embodiment of the present invention, the driving arm can be moved using at least three axes, so the sample container 20 can be moved left and right, up and down, and forward and backward.

The pump module 300 injects a stock solution or strong acid into the sample container.

According to one embodiment of the present invention, the pump module 300 includes a strong acid nozzle unit 310 and an undiluted solution injection unit 320.

The strong acid nozzle part 310 injects strong acid into the sample container based on the set sample dilution conditions. When the strong acid nozzle part 160 is connected to the pump module 300 to inject strong acid into the sample container, the nozzle is connected to the strong acid nozzle part 160. You can use this to inject strong acid into the sample container.

The stock solution injection unit 320 injects the stock solution into the sample container based on the set sample dilution conditions. When the pipette tip that can transfer the stock solution from the pipette rack part 170 to the bottom of the pump module 300 is coupled, the drive module (200) The stock solution can be injected into the sample container using a pipette.

According to one embodiment of the present invention, the stock solution injection unit and the strong acid nozzle unit are opened and closed or the strong acid nozzle unit is opened and closed after the sample container moves to the strong acid nozzle part 160 or the pipette rack part 170 based on the control message from the controller. The nozzle part can be opened and closed.

The control unit 500 may control the operation of the drive module or generate a control message to control the pump module according to preset sample dilution conditions and dispensing order.

The control unit 500 is described in detail in FIG. 2 below.

Referring to FIG. 2, the control unit 500 of the gravimetry-based sample dilution and dispensing device 10 according to an embodiment of the present invention includes a processor 510, a memory 520, and a communication unit 530.

The control unit 500 according to an embodiment of the present invention controls the operation of the drive module or generates a control message to control the pump module according to preset sample dilution conditions and dispensing order.

Specifically, the processor 510 receives the weight measurement result from the weight measurement module 400 and feedback controls at least one of the driving module 200 and the pump module 300 based on the weight measurement result.

The process by which the control unit 500 controls the drive module 200 and the pump module 300 according to the dilution operation sequence will be described as an example.

Based on the control message from the control unit 500, the driving module 200 of the gravimetry-based sample dilution and dispensing device removes the empty sample container from the sample holder 110 and then caps it from the capping/decapping part 150. Open, place an empty sample container on the measurement part 140, and set the zero point.

Afterwards, before adding the stock solution, shake the container containing the stock solution a predetermined number of times on the shaker part and then add the stock solution. At this time, the pump module 300 moves the pipette tip from the pipette rack part 170 based on the preset first dilution ratio. Connect and inject the stock solution into the sample container.

The measurement part 140 measures the weight of the sample container, and if the weight measurement result reaches a preset target weight, the control unit 500 controls the stock solution injection unit to stop administering the stock solution.

Meanwhile, the weight measurement module 400 records the weight measurement results.

Thereafter, the pump module 300 injects the diluent (nitric acid) into the sample container from the strong acid nozzle part 160 based on the preset target ratio.

The measurement part 140 measures the weight of the sample container, and if the weight measurement result reaches a preset target weight, the control unit 500 controls the strong acid nozzle unit to stop administering the strong acid.

When the target weight is reached, the driving module 200 takes the sample container 20 out of the weighing module 400, closes the cap in the capping/decapping part 150, and mixes the diluent in the shaker part 120. Afterwards, it is placed in the sample holder 110.

The memory 520 stores the weight measurement results transmitted from the weight measurement module 400, and is divided into three types: flash memory type, hard disk type, multimedia card micro type, Card-type memory (e.g., SD or It may include at least one type of computer-readable storage medium among (Only Memory), PROM (Programmable Read-Only Memory), magnetic memory, magnetic disk, and optical disk.

The communication unit 530 can transmit the generated control message to the driving module 200 and the pump module 300, and can receive preset sample dilution conditions and dispensing order from the outside.

Referring to FIG. 3, the gravimetry-based sample dilution and dispensing device 10 according to an embodiment of the present invention includes a base unit 100, a drive module 200, a pump module 300, and a weight measurement module 400. ) and the control unit 500, it may further include a nitric acid tank and recovery storage box 600 and an automatically opening and closing acid gas exhaust port 700.

According to one embodiment of the present invention, the control unit 500 may be located at the bottom of the base unit 100 and the driving module 200.

The driving module 200 includes a driving arm 210 and a moving unit 220.

The driving arm 210 may hold at least one sample container 20.

The moving unit 220 may include a rail and a motor (not shown), and includes a first rail 220a installed along the X-axis direction, a second rail 220b installed along the Y-axis direction, and a Z-axis direction. It may include a third rail 220c installed along.

Additionally, according to one embodiment of the present invention, the pump module 300 is connected to the driving arm 210 and can move integrally with the movement of the driving module 200.

Accordingly, with the sample container 20 located in the weight measurement module 400, the stock solution injection and the strong acid injection can be performed by replacing the strong acid nozzle connection and the pipette connection.

In one embodiment of the present invention, the weight measurement module 400 may be a scale, and the gravimetric method-based sample dilution and dispensing device determines the concentration of the sample solution by diluting the stock solution with a strong acid while measuring the weight of the sample container. It can be adjusted according to conditions (ranging from ppm to several percent).

As shown in (a) of FIG. 5, the weight measurement module 400 includes a space portion 410 in which a sample container can be contained in the inner central portion.

As shown in (b) of FIG. 5, the driving module 200 places the sample container 20 in the space 410, places the sample container 20 on the weight measurement module 400, and sets the zero point. Match.

Figures 5 (b) and (c) show, as an example, the pump module 300 connecting a pipette and injecting a stock solution into a sample container.

As shown in (b) and (c) of FIG. 5, while injecting the stock solution into the sample container based on the first preset dilution ratio, the weight of the sample container is stored after sample injection in the measurement part 140, and then the acid Measure the total weight after injection. If the weight measurement result reaches a preset target weight, the control unit 500 controls the stock solution injection unit to stop administering the stock solution.

As shown in (a) of FIG. 6, the shaker part 120 includes a fixing part 121 at the inner central portion to which one side of the sample container can be fixed.

As shown in (b) of FIG. 6, the driving module 200 can fix the sample container 20 to the fixing part 121, and shaker part 120 with one side of the sample container 20 fixed. ), the sample container 20 can mix the diluted solution.

Figure 6 (c) shows an example of the driving module 200 fixing the sample container 20 to the fixing part 121 of the shaker part 120.

The driving arm 210 of the driving module 200 can be fixed to the fixing part 121 of the shaker part 120 while pressing both sides of the sample container 20 with the robot chuck 211.

As shown in (a) of Figure 7, according to one embodiment of the present invention, the pump module 300 is connected to the drive arm 210 and can move integrally with the movement of the drive module 200, and the bottom It may include a strong acid nozzle unit 310 that injects strong acid into the sample container.

In addition, as shown in (b) of FIG. 7, the strong acid nozzle unit 310 of the pump module 300 may be connected to the recovery hose 311, and after injecting the strong acid into the sample container, the recovery hose 311 Strong acids can be discharged to the outside.

Additionally, the pump module 300 may be connected to the strong acid supply hose 312, and strong acid may be injected into the pump module through the strong acid supply hose 312.

In one embodiment of the present invention, the pump module 300 is moved to the strong acid part 130 to pre-contain nitric acid that can be added to the sample container, and the pump module 300 is moved from the strong acid nozzle part 160 to the sample container. A strong acid nozzle may be connected to inject strong acid into the container.

Additionally, when the strong acid nozzle is connected, it moves toward the sample container 20 and injects strong acid into the sample container 20.

As shown in (a) of FIG. 8, according to one embodiment of the present invention, the capping/decapping part 150 may include a fastening portion 151 that is fastened to the sample container.

As shown in (c) of FIG. 8, the driving arm 210 fixes the cap of the sample container, and after the sample container is engaged with the fastening part 151, the cap is opened or closed by rotation.

Referring to FIG. 9, the sample holder 110 includes a sample holder 111 on which the sample container 20 can be mounted.

As shown in (a) of FIG. 9, the sample holder 110 includes a sample holder 111 on which the sample container 20 can be mounted.

As shown in FIG. 9 below, the sample holder 111 may include a stock solution sample line 111a containing stock solution samples and a plurality of dilution sample lines 111b containing samples diluted by a plurality of concentrations. .

In one embodiment of the present invention, the stock solution may be prepared in advance in the stock solution sample line 111a of the sample holder 110, and when a pipette capable of transferring the stock solution is coupled to the bottom of the pump module 300, the drive module ( 200) can inject the stock solution into the sample container using a pipette.

In addition, when the target weight is reached, the driving module 200 takes the sample container 20 out of the weight measurement module 400, closes the cap on the capping/decapping part 150, and removes the diluent from the shaker part 120. After mixing, it is placed in the sample holder 110, and at this time, it is placed in the dilution sample line 111b.

In one embodiment of the present invention, the dilution sample line 111b is provided as a plurality of lines and can be separated differently depending on the dilution concentration.

Referring to Figures 10 (a) and (b), the pipette rack part 170 includes a pipette storage unit 171, and a plurality of pipettes 30 are stored in an upright position in the pipette storage unit 171. .

As shown in (c) of FIG. 10, the stock solution injection unit 320 further includes a pipette coupling portion at the bottom to which the pipette tip 30 capable of transferring the stock solution is detachably coupled, and the pipette tip 30 is coupled. In this state, the driving module 200 can move to the stock solution sample line 111a of the sample holder 110, contain the stock solution using a pipette, and then inject the stock solution into the sample container.

Specifically, the pipette removal part 180 includes a pipette recovery unit 181 that can recover the pipette tip 30.

When the pipette coupling part is released from its coupling with the pipette tip 30 in the pipette removal part 180, the pipette tip 30 is contained in the pipette recovery part 181.

The description of the present invention described above is for illustrative purposes, and those skilled in the art will understand that the present invention can be easily modified into other specific forms without changing the technical idea or essential features of the present invention. will be. Therefore, the embodiments described above should be understood in all respects as illustrative and not restrictive. For example, each component described as unitary may be implemented in a distributed manner, and similarly, components described as distributed may also be implemented in a combined form.

The scope of the present invention is indicated by the claims described below, and all changes or modified forms derived from the meaning and scope of the claims and their equivalent concepts should be construed as being included in the scope of the present invention.

Claims

A base portion divided into a plurality of space units, where sample dilution and dispensing processes are performed in each space;

a driving module including a driving arm that holds at least one sample container and moving the sample container to each space of the base portion;

A pump module for injecting a stock solution or strong acid into the sample container; and

A gravimetry-based sample dilution and dispensing device comprising a weight measurement module that measures the weight of the sample container and records the weight measurement result.
According to paragraph 1,

A gravimetry-based sample dilution and dispensing device further comprising a control unit that controls driving of the driving module or generates a control message to control the pump module according to preset sample dilution conditions and dispensing order.
According to paragraph 2,

The control unit,

A gravimetry-based sample dilution and dispensing device, characterized in that it receives the weight measurement result from the weight measurement module and feedback controls at least one of the drive module and the pump module based on the weight measurement result.
According to paragraph 1,

The base part,

It includes a sample holder including a sample holder on which the sample container can be mounted,

The sample holder,

A concentrate sample line containing a sample of the concentrate; and

A gravimetric-based sample dilution and dispensing device including a plurality of dilution sample lines containing samples diluted by a plurality of concentrations.
According to paragraph 1,

The base part,

A gravimetric method-based sample dilution and dispensing device including a shaker part in which the driving arm is provided to shake the diluted solution a predetermined number of times before dispensing the stock solution or when a strong acid is added to the sample container to dilute it.
According to paragraph 1,

The driving module is,

A gravimetric method-based sample dilution and dispensing device further comprising a moving unit connected to the driving arm and moving the driving arm to each space of the base using at least three axes.
According to paragraph 2,

The pump module is,

a stock solution injection unit for injecting stock solution into the sample container; and

It includes a strong acid nozzle unit that injects strong acid into the sample container,

A gravimetric method-based sample dilution and dispensing device, wherein the stock solution injection unit and the strong acid nozzle unit open and close or the strong acid nozzle unit opens and closes based on the control message from the control unit.
In clause 7,

The undiluted solution injection part,

A gravimetric method-based sample dilution and dispensing device further comprising a pipette coupling portion at the bottom to which a pipette tip capable of transferring the stock solution is detachably coupled.
In clause 7,

The undiluted solution injection part,

Injecting the stock solution into the sample container based on the set sample dilution conditions,

The control unit controls the stock solution injection unit to stop administering the stock solution when the weight measurement result reaches a preset target weight.
According to clause 9,

The strong acid nozzle part,

Injecting the strong acid into the sample container based on the set sample dilution conditions,

The control unit controls the strong acid nozzle unit to stop administering the strong acid when the weight measurement result reaches a preset target weight.