WO2024042908A1 - Guide d'ions et dispositif de spectrométrie de masse le comprenant - Google Patents

Guide d'ions et dispositif de spectrométrie de masse le comprenant Download PDF

Info

Publication number
WO2024042908A1
WO2024042908A1 PCT/JP2023/025965 JP2023025965W WO2024042908A1 WO 2024042908 A1 WO2024042908 A1 WO 2024042908A1 JP 2023025965 W JP2023025965 W JP 2023025965W WO 2024042908 A1 WO2024042908 A1 WO 2024042908A1
Authority
WO
WIPO (PCT)
Prior art keywords
ion guide
electrode
electric field
axial electric
multipole
Prior art date
Application number
PCT/JP2023/025965
Other languages
English (en)
Japanese (ja)
Inventor
益之 杉山
英樹 長谷川
雄一郎 橋本
Original Assignee
株式会社日立ハイテク
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社日立ハイテク filed Critical 株式会社日立ハイテク
Publication of WO2024042908A1 publication Critical patent/WO2024042908A1/fr

Links

Images

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements

Definitions

  • the present disclosure relates to an ion guide and a mass spectrometer equipped with the same.
  • Ion guides are widely used to transport ions within mass spectrometers.
  • the ion guide used in the collision cell of a tandem mass spectrometer it is necessary to generate an axial electric field on the central axis to prevent crosstalk.
  • the axial electric field for example, Patent Document 1 discloses generating an axial electric field that accelerates ions in a multipole ion guide configured of parallel rod electrodes of multiple poles (such as quadrupole).
  • Patent Document 2 discloses that an axial electric field is generated by inserting a resistor electrode to which a high frequency voltage is applied into a gap between multipole electrodes to which a high frequency electrode is applied.
  • the ion guide disclosed in Patent Document 2 has a complicated configuration, has narrow intervals between electrodes, and has a small surface area of the electrodes that form an axial electric field. For this reason, there is also the problem that the electrode surface is easily contaminated by impurities such as neutral droplets introduced into the ion guide, resulting in a decrease in performance.
  • the present disclosure proposes a technique for realizing an ion guide that has a wide m/z range of ions that can pass through the ion guide, has a simple structure, and is resistant to contamination.
  • the present disclosure provides an ion guide into which ions are introduced, the ions are converged and emitted, and includes a multipole electrode for forming a multipolar electric field and a multipolar electrode for forming an axial electric field.
  • An ion guide is proposed in which the cross-sectional area perpendicular to the central axis of the ion guide of at least one of the multipole electrode and the axial electric field electrode changes from the entrance to the exit of the ion guide.
  • an ion guide that has a simple structure, is resistant to contamination, and transmits a wide mass range, and a mass spectrometer equipped with the same.
  • FIG. 1 is a sectional view showing a schematic configuration example of a mass spectrometer 10 including a curved ion guide 20 according to the first embodiment.
  • FIG. 2 is a diagram showing an example of the external configuration of an ion guide 20 according to the first embodiment. 2 is a diagram showing an example of a cross-sectional configuration of the ion guide 20 according to the first embodiment taken along the central axis 23.
  • FIG. FIG. 2 is a diagram showing an example of a cross-sectional configuration of an inlet 1A and an outlet 1B of the ion guide 20 according to the first embodiment. It is a figure showing an example of composition of ion guide power supply 300 used in each embodiment.
  • FIG. 3 is a diagram showing pseudopotentials in the ry plane at the entrance 1A and exit 1B of the ion guide 20 according to the first embodiment.
  • FIG. 3 is a diagram showing a DC potential in an xz plane including a central axis 23 of the ion guide 20 according to the first embodiment.
  • 6 is a diagram showing the potential (a function of ⁇ in FIGS. 2 and 5) on the central axis 23 of the ion guide 20 according to the first embodiment.
  • FIG. FIG. 3 is a diagram showing the DC potential of the yr plane at the entrance 1A and exit 1B of the ion guide 20 according to the first embodiment.
  • FIG. 4 is a diagram showing the distribution of transmission times of 200 ions under conditions of potential differences of 6 V, 3 V, 1.5 V, and 1 V between the axial electric field electrode 22 and the multipole electrode 21.
  • FIG. 3 is a diagram showing the transmittance of ions of m/z 150 to m/z 4000 under conditions where the potential difference between the axial electric field electrode 22 and the multipole electrode 21 is 3 V and 6 V.
  • FIG. FIG. 3 is a diagram showing a schematic configuration example of an ion guide 201 according to a second embodiment. 7 shows a schematic configuration example of an ion guide 202 according to a third embodiment. It is a figure which shows the example of a structure of the ion guide 203 by 4th Embodiment. It is a figure which shows the example of a structure of the ion guide 204 by 5th Embodiment.
  • At least one of the cross-sectional area (area of the plane perpendicular to the ion traveling direction) with respect to the central axis of the multipole electrode or the cross-sectional area with respect to the central axis of the axial electric field electrode extends from the entrance to the exit of the ion guide. It is disclosed that by changing the m/z range of ions that can pass through the ion guide, an ion guide that has a simple structure and is resistant to contamination is realized.
  • FIG. 1 is a sectional view showing a schematic configuration example of a mass spectrometer 10 including a curved ion guide 20 according to the first embodiment.
  • the mass spectrometer 10 includes an ion source 101, a first differential pumping section 102 including an ion guide 121 for ion transport if necessary, and a vacuum pumping system that evacuates air from the first differential pumping section 102.
  • a second differential pump 103 including an ion guide (curved ion guide) 20, a vacuum pump 132 that evacuates the air in the second differential pump 103 to create a vacuum, and a voltage
  • a mass spectrometry chamber 104 having a mass filter 125, a collision cell 126, and a detector 127, and a vacuum pump 133 that evacuates the air in the mass spectrometry chamber 104 to create a vacuum.
  • an electrospray ion source an atmospheric pressure chemical ion source, an atmospheric pressure photo ion source, an atmospheric pressure matrix-assisted laser desorption ion source, or the like can be used.
  • the ions generated in the ion source 101 pass through the pores 111 provided in the first differential pumping section 102 along with the airflow, and are introduced into the first differential pumping section 102 (vacuum chamber).
  • the ions that have passed through the differential pumping section 102 pass through the pores 112 provided in the connection section (wall) between the first differential pumping section 102 and the second differential pumping section 103, and the ions pass through the ion guide according to the technology of the present disclosure. 20 will be introduced.
  • a voltage is applied to the ion guide 20 by an ion guide power source 300. Further, the pressure at which the ion guide 20 operates is approximately 1000 Pa to 10 ⁇ 3 Pa. In particular, at 1000 Pa to 0.1 Pa, the kinetic energy of ions is cooled by collision with neutral gas molecules, so ions can be focused efficiently.
  • the ions ejected from the ion guide 20 pass through a pore 113 provided at the connection (wall) between the second differential pumping section 103 and the mass spectrometry chamber 104 and are introduced into the mass spectrometry chamber 104 .
  • the mass spectrometer 10 is, for example, a tandem mass spectrometer
  • precursor ions of a specific m/z are selected by the mass filter 125 and dissociated in the collision cell 126.
  • Fragment ions generated by collision cell 126 are detected by detector 127.
  • the detector 127 an electron multiplier tube or the like can be used.
  • the ion guide 20 can also be used as the collision cell 126.
  • FIG. 2 is a diagram showing a configuration example of the ion guide according to the first embodiment.
  • FIG. 2A is a diagram showing an example of the external configuration of the ion guide 20.
  • FIG. 2B is a diagram showing an example of a cross-sectional configuration of the ion guide 20 taken along the central axis 23.
  • FIG. 2C is a diagram showing an example of the cross-sectional configuration of the inlet 1A and outlet 1B of the ion guide 20.
  • the ion guide 20 has a curved shape (curved ion guide), and is sandwiched between two upper and lower plate-shaped multipole electrodes 21, and the upper and lower multipole electrodes. It is equipped with two upper and lower axial field electrodes 22, and ions enter from the entrance 1A and accelerated ions exit from the exit 1B.
  • the ion guide 20 is configured such that the central axis 23 is a quarter arc having an ion guide arc center 29.
  • the cross section of the inlet 1A of the ion guide 20 is on the x-axis
  • the cross-section of the outlet 1B is on the z-axis.
  • the axial electric field electrode 22 is configured such that its cross-sectional area increases from the inlet 1A to the outlet 1B. It can also be seen from FIG. 2B that the size of the axial electric field electrode 22 (on the xz plane) decreases from the entrance 1A to the exit 1B.
  • the potential that the axial electric field electrode 22 forms on the central axis (ion guide central axis) 23 of the ion guide 20 depends on the area of the axial electric field electrode 22 visible from above the ion guide central axis 23.
  • An axial electric field is formed according to the potential difference between the potential of the multipole electrode 21 and the potential of the axial electric field electrode 22.
  • the symbols "+" and "-" indicate the phase of the RF voltage applied from the ion guide power source 300 to the multipole electrode 21 and the axial electric field electrode 22. RF voltages of the same phase and frequency are applied to electrodes with the same reference numerals.
  • An RF voltage having a phase opposite to that of the adjacent multipole electrode 21 is applied to the multipole electrode 21 in order to generate a multipole electric field that confines ions. Further, an RF voltage having the same phase and substantially the same amplitude as that of the adjacent multipole electrode 21 is applied to the axial electric field electrode 22 . By applying the voltage in this manner, no potential difference in RF voltage is generated between the multipole electrode 21 and the axial electric field electrode 22, which have narrow electrode spacing, and discharge can be prevented. Furthermore, different offset DC voltages are applied to the set (pair) of multipole electrodes 21 and the set (pair) of axial electric field electrodes 22, respectively.
  • Ions pass through the central axis 23 of the ion guide 20, but since the area of the cross section perpendicular to the central axis 23 of the axial electric field electrode 22 visible from the central axis 23 changes according to the distance on the central axis 23, the center The intensity of the DC voltage applied to the axial electric field electrode 22 by the ions on the shaft 23 changes. This causes the ions to be accelerated.
  • FIG. 3 is a diagram showing a configuration example of an ion guide power source 300 used in each embodiment.
  • FIG. 3 shows two types of configuration examples of the ion guide power source 300.
  • the ion guide power source 300 includes an axial electric field electrode DC power source 301, a multipole electrode DC power source 302, and an RF power source 303.
  • a DC voltage is supplied from an electrode DC power supply 301 or a multipole electrode DC power supply 302.
  • the RF power source 303 includes an AC power source and a plurality of coils, and uses each coil to apply an RF voltage having the same phase and amplitude to the multipole electrode 21 and the axial electric field electrode 22.
  • FIG. 4 is a diagram showing pseudopotentials in the ry plane at the entrance 1A and exit 1B of the ion guide 20.
  • the pseudopotential was measured with an ion m/z of 600 and an RF voltage amplitude of 300V0-peak.
  • An RF voltage of the same phase and approximately the same amplitude as that of the adjacent multipole electrode 21 is applied to the axial electric field electrode 22, and a set of the multipole electrode 21 and the adjacent axial electric field electrode 22 forms a multipole pole. . Therefore, the axial electric field electrode 22 does not block the multipole electrode 21, and pseudopotential distortion is less likely to occur.
  • the length of the axial electric field electrode 22 in the r-axis direction is shorter (the electrode width is smaller), and the distance from the ion guide central axis 23 is farther, so the pseudopotential is shallower. Become. Therefore, the pseudopotential becomes deeper as it approaches the ion guide exit 1B, resulting in a funnel-like potential. This makes it possible to efficiently converge the ion distribution.
  • charged droplets, neutral contaminants, and the like are introduced into the vacuum chamber along with ions, causing contamination inside the device.
  • ions travel straight in the z-axis direction in FIG. 2 from the pore 112 in front of the entrance 1A of the ion guide 20.
  • ions introduced from the entrance 1A of the ion guide 20 are focused near the minimum point of the pseudopotential on the central axis 23, move along the central axis 23, and are ejected from the exit 1B of the ion guide 20. .
  • the inlet 1A exists in the xy plane and the outlet 1B exists in the yz plane, so charged droplets and neutral contaminants go straight from the inlet 1A of the ion guide 20 in the z-axis direction and reach the ion guide 20. Only ions are excluded from the ion guide 20 and pass through the ion guide 20. This makes it possible to reduce noise.
  • the charged droplets and neutral contaminants introduced into the pores 112 spread over a range of several mm and travel straight in the z-axis direction, as shown in FIG.
  • the ion guide 20 no electrode exists in the range in front of the entrance 1A (in the z-axis direction) through which charged droplets and neutral contaminants pass, and a wide gap (space) is formed. Therefore, the ion guide 20 is less likely to be contaminated by neutral contaminants or charged droplets colliding with the electrodes (multipole electrode 21 and axial electric field electrode 22), and is resistant to contamination.
  • FIG. 5 is a diagram showing the DC potential in the xz plane including the central axis 23 of the ion guide 20.
  • FIG. 6 is a diagram showing the potential on the central axis 23 of the ion guide 20 (a function of ⁇ in FIGS. 2 and 5). Note that the DC potential is calculated assuming that the potential difference between the axial electric field electrode 22 and the multipole electrode 21 is 10V.
  • the DC potential on the xz plane is dense near the entrance 1A and sparse near the exit 1B, so it is highest at the entrance 1A of the ion guide 20 and increases toward the exit 1B of the ion guide 20. gradually decreases. Further, as can be seen from FIG. 6, the potential decreases along the central axis 23 of the ion guide 20 in approximately proportion to the angle ⁇ from the center of curvature. The potential on the central axis 23 allows the ions to be constantly accelerated at a constant acceleration.
  • FIG. 7 is a diagram showing the DC potential of the yr plane at the entrance 1A and exit 1B of the ion guide 20.
  • the potential at the entrance 1A of the ion guide 20 includes components of higher-order dipoles such as octupole in addition to quadrupole components. Therefore, compared to the case where a quadrupole DC potential is applied due to the effect of higher-order terms, it becomes possible to efficiently transmit ions in a wide m/z range.
  • the multipole electrode at the exit 1B of the ion guide 20 is covered with the axial electric field electrode, it can be seen that the DC potential on the yr plane is almost uniform. Therefore, the spatial distribution of ions does not spread due to the DC potential, and the spatial distribution of ions can be converged.
  • FIG. 8 is a diagram showing the distribution of transmission times of 200 ions under conditions of potential differences of 6 V, 3 V, 1.5 V, and 1 V between the axial electric field electrode 22 and the multipole electrode 21.
  • Table 1 also shows parameter values other than the potential difference between the axial electric field electrode 22 and the multipole electrode 21.
  • the transmission time is 1 ms or less when the potential difference between the axial electric field electrode 22 and the multipole electrode 21 is 3V or more, and the transmission time is the shortest when the potential difference is 6V.
  • the transmission time can be kept short and signal crosstalk can be avoided.
  • ⁇ Ion m/z range simulation results>
  • a simulation was performed to confirm the m/z range of ions that can stably pass through the ion guide 20.
  • the lower limit of the m/z of ions that can stably pass through the ion guide 20 is determined by the low mass cut off value (LMCO), which is the lower limit of the stability region of Matthew's equation.
  • LMCO low mass cut off value
  • the LMCO of a monovalent ion is given by the following equation (1).
  • V is the RF voltage amplitude
  • m is the mass of the ion
  • q LMCO is the q value of Matthew's equation in LMCO
  • e is the elementary charge
  • ⁇ is the RF voltage frequency
  • r 0 is the radius of the quadrupole inscribed circle.
  • Equation (1) it can be seen that since the pseudopotential is inversely proportional to the m/z of the ion, ions with a high m/z have a low pseudopotential and are excluded by the DC potential. Furthermore, the higher the RF voltage amplitude, the higher the pseudopotential, and therefore the higher the upper limit of m/z of ions that can pass through.
  • FIG. 9 is a diagram showing the transmittance of ions of m/z 150 to m/z 4000 under conditions where the potential difference between the axial electric field electrode 22 and the multipole electrode 21 is 3V and 6V.
  • the potential difference between the axial electric field electrode 22 and the multipole electrode 21 was 3V, an average transmittance of 97% was obtained for ions in the range of m/z 175 to m/z 2500, that is, LMCO to LMCO ⁇ 14.3.
  • the potential difference between the axial electric field electrode 22 and the multipole electrode 21 is 6V, an average transmittance of 97% is obtained for ions in the range of m/z 175 to m/z 1500, that is, LMCO to LMCO ⁇ 8.6. Ta.
  • the ion guide 20 according to this embodiment can transmit ions in a wide m/z range. Further, according to the ion guide 20 according to the present embodiment, since both the multipole electrode 21 and the axial electric field electrode 22 are plate-shaped electrodes, there is a degree of freedom in the configuration of the ion guide 20 from the viewpoint of ease of manufacture, and the design concept is the same. This makes it possible to handle even 1/2 circular arcs and more complex flow path shapes. Therefore, it is possible to flexibly implement the mass spectrometer 10 according to its footprint (bottom area) and shape in the future.
  • FIG. 10 is a diagram showing a schematic configuration example of an ion guide 201 according to a second embodiment.
  • the ion guide 201 has a linear shape and includes a multipole electrode 21 and an axial electric field electrode 22, and the length of the axial electric field electrode 22 that forms an axial electric field in the x direction is short at the entrance 10A (the cross-sectional area of the electrode is (small) and long (the cross-sectional area of the electrode is large) at the outlet 10B.
  • the configuration of the ion guide 201 in the radial cross section, the pseudopotential, the DC potential, and the potential on the central axis 23 are the same as in the first embodiment.
  • the ion guide 201 since the ion guide 201 has a linear shape, it has a simpler structure and can be implemented at a lower cost than the ion guide 20 according to the first embodiment. On the other hand, since the direction in which ions enter the ion guide 201 and the direction in which the ions exit from the ion guide 201 are the same, the effect of reducing noise is smaller than in the first embodiment.
  • FIG. 11 shows a schematic configuration example of an ion guide 202 according to a third embodiment.
  • the multipole electrode 21 and the axial electric field electrode 22 exist within the same xz plane. That is, in the first and second embodiments, the ion guide 20 or 201 is constructed by arranging the multipole electrode 21 and the axial electric field electrode 22 so as to spatially overlap in the z-axis direction (see FIGS. 2A and 2B). , see FIG.
  • the multipole electrode 21 forming a trapezoidal or triangular flat plate and the axial electric field electrode 22 forming a trapezoidal or triangular plate are bonded together on the sides (short side (apex) side
  • the ion guide 202 is constructed using four substantially rectangular flat plate electrodes (one pair each on the upper and lower sides), each of which has a configuration in which the long sides (bottom sides) are stuck together.
  • the ion guide 202 may be configured by using four apparently rectangular flat plate electrodes (one pair each at the top and bottom), which are arranged with their sides facing each other, without bonding them together.
  • the length of the multipole electrode 21 in the x direction is long at the entrance 11A of the ion guide 202 and short at the exit 11B.
  • the length of the axial electric field electrode 22 in the x direction is short at the entrance 11A of the ion guide 202 and becomes long at the exit 11B.
  • An axial electric field is formed by such an electrode configuration.
  • the ion guide 202 according to the third embodiment since the multipole electrode 21 and the axial electric field electrode 22 exist on the same plane (xz plane), the ion guide 202 according to the first embodiment The spacing between the electrodes becomes wider. For this reason, the incident charged droplets and neutral contaminants are less likely to collide with the electrodes, and the ion guide 202 has the characteristic of being resistant to contamination. On the other hand, the depth of the pseudopotential along the central axis 23 is constant, and the efficiency of focusing ions is relatively low (compared to the first embodiment).
  • FIG. 12 is a diagram showing a configuration example of an ion guide 203 according to a fourth embodiment.
  • the ion guide 203 is configured such that the width of the axial electric field electrode 22 in the r-axis direction (xz plane) is constant, and the width of the multipole electrode 21 in the r-axis direction (xz plane) changes depending on the position on the central axis of the ion guide. It is composed of
  • the potential that the multipole electrode 21 forms on the central axis 23 of the ion guide 203 depends on the area of the multipolar electrode 21 visible from above the central axis 23 of the ion guide 203. Therefore, an axial electric field is formed on the central axis 23 of the ion guide 203 according to the potential difference between the multipole electrode 21 and the axial electric field electrode 22.
  • FIG. 13 is a diagram showing a configuration example of an ion guide 204 according to a fifth embodiment.
  • the ion guide 204 includes a second multipole electrode (an additional multipole electrode) located closer to the central axis 23 than the axial electric field electrode 22. . The same voltage is applied to the first multipole electrode 22 and the second multipole electrode 28.
  • the ion guide 204 has a somewhat more complicated configuration than the ion guide 20 according to the first embodiment, the DC potential at the entrance 13A of the ion guide 204 approaches a higher-order multipole. Therefore, the ion guide 204 has the advantage that the m/z range of transmitted ions is wider than that of the ion guide 20 according to the first embodiment.
  • the ion guide in the ion guide according to the present disclosure, at least one of the ion guides (20 and 201 to 204) of the multipole electrode 21 or the axial electric field electrode 22
  • the cross-sectional area perpendicular to the central axis changes from the entrance (1A, 10A, 11A, 12A, 13A) to the exit (1B, 10B, 11B, 12B, 13B) of the ion guide.
  • the cross-sectional area of the axial electric field electrode 22 perpendicular to the central axis 23 of the ion guide changes (increases) from the entrance 1A to the exit 1B of the ion guide 20.
  • a funnel-like potential can be created in which the pseudopotential becomes deeper as it approaches the ion guide exit 1B, and the ion distribution can be efficiently converged.
  • the multipole electrodes 21 and the axial electric field electrodes 22 are each installed as two pairs of plate-shaped electrodes. Further, the shapes of the multipole electrode and the axial electric field electrode are both arcuate from the inlet to the outlet (curved electrode).
  • the ion guide power supply 300 applies an RF voltage with the same phase and amplitude to the multipole electrode 21, and applies different DC voltages to the multipole electrode 21 and the axial electric field electrode 22 so that a potential difference is generated between the multipole electrode 21 and the axial electric field electrode 22. Ru. By applying the voltage in this manner, no potential difference in RF voltage is generated between the multipole electrode 21 and the axial electric field electrode 22, which have narrow electrode spacing, and discharge can be prevented.
  • the potential decreases along the central axis 23 of the ion guide 20 in approximately proportion to the angle ⁇ from the center of curvature.
  • the potential on the central axis 23 allows the ions to be constantly accelerated at a constant acceleration.
  • the multipole electrode at the exit 1B of the ion guide 20 is covered with an axial electric field electrode, the DC potential on the yr plane becomes almost uniform. Therefore, the spatial distribution of ions does not spread due to the DC potential, and the spatial distribution of ions can be converged.
  • the ion guide 20 it is possible to transmit ions in a wide m/z range.
  • the cross-sectional area of the axial electric field electrode 22 perpendicular to the central axis 23 of the ion guide is multiplied by the distance from the inlet 10A to the outlet 10B of the ion guide 201.
  • the shape of the multipole electrode 21 and the axial electric field electrode 22 are both linear. Even when the ion guide 201 according to the second embodiment is used, the same technical effects as in the first embodiment can be expected (voltage application is the same as in the first embodiment).
  • the plate-shaped axial electric field electrode 22 is configured such that the cross-sectional area perpendicular to the central axis 23 increases from the inlet 11A to the outlet 11B, and
  • the polar electrode 21 is configured such that the same cross-sectional area becomes smaller from the inlet 11A to the outlet 11B (see FIG. 11).
  • the axial electric field electrode 22 and the multipole electrode 21 are arranged on the same plane so that their respective side surfaces face each other (attached on the side surfaces, or arranged in parallel within the same plane (xz plane)). . Even in this case, the same technical effects as in the first embodiment can be expected (voltage application is the same as in the first embodiment).
  • the axial electric field electrode 22 is configured such that the cross-sectional area perpendicular to the central axis 23 of the ion guide is the same from the inlet 12A to the outlet 12B, and the multipole electrode 22 is configured such that the same cross-sectional area increases from the inlet 12A to the outlet 12B (see FIG. 12).
  • the multipole electrode 21 is configured to be relatively larger than the axial electric field electrode 22 (configuring the multipole electrode 21 to cover the axial electric field electrode 22), it is possible to achieve the same technical advantages as in the first embodiment. Effects can be expected (voltage application is the same as in the first embodiment).
  • the cross-sectional area perpendicular to the central axis 23 of the ion guide of the axial electric field electrode 22 arranged closer to the central axis 23 than the multipole electrode 21 is the entrance of the ion guide 20.
  • the multipole electrode 21 increases in size from 1A to the exit 1B, and is arranged so as to cover the axial electric field electrode 22 (the configuration up to this point is the same as the first embodiment).
  • an additional multipole electrode 28 is provided closer to the central axis 23 than the axial field electrode 22 . This makes it possible to further widen the m/z range of transmitted ions.
  • Multipolar electrode 22 Axial electric field electrode 23 Central axis of ion guide 28 Second multipolar electrode (additional multipolar electrode) 29 Arc center of central axis of ion guide 101 Ion source 102 First differential pumping section 103 Second differential pumping section 104 Mass spectrometry chambers 111, 112, 113 Pore 121 Ion guide (for ion transport) 125 Mass filter 126 Collision cells 131, 132, 133 Vacuum pump 300 Ion guide power supply 301 Axial electric field electrode DC power supply 302 Multipole electrode DC power supply 303 RF power supply

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Electron Tubes For Measurement (AREA)

Abstract

Afin d'obtenir un guide d'ions dont la plage de m/z des ions qui peuvent passer à travers celui-ci est large, et dont la structure est simple et résistante à la contamination, la présente demande propose (voir fig. 2A) un guide d'ions dans lequel sont introduits des ions. Le guide d'ions fait converger ces ions et émet le résultat, il comprend une électrode multipolaire destinée à former un champ électrique multipolaire et une électrode de champ électrique axial destinée à former un champ électrique axial. La section transversale perpendiculaire à l'axe central du guide d'ions d'au moins une électrode multipolaire et de l'électrode de champ électrique axial varie d'une entrée du guide d'ions à une sortie de celui-ci.
PCT/JP2023/025965 2022-08-23 2023-07-13 Guide d'ions et dispositif de spectrométrie de masse le comprenant WO2024042908A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2022132186A JP2024029800A (ja) 2022-08-23 2022-08-23 イオンガイド、およびそれを備える質量分析装置
JP2022-132186 2022-08-23

Publications (1)

Publication Number Publication Date
WO2024042908A1 true WO2024042908A1 (fr) 2024-02-29

Family

ID=90013074

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2023/025965 WO2024042908A1 (fr) 2022-08-23 2023-07-13 Guide d'ions et dispositif de spectrométrie de masse le comprenant

Country Status (2)

Country Link
JP (1) JP2024029800A (fr)
WO (1) WO2024042908A1 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005522845A (ja) * 2002-04-05 2005-07-28 エムディーエス　インコーポレイテッド　ドゥーイング　ビジネス　アズ　エムディーエス　サイエックス 高次の多重極電界、低圧イオン・トラップ内での共振励起によるイオンのフラグメンテーション
JP2011023184A (ja) * 2009-07-15 2011-02-03 Hitachi High-Technologies Corp 質量分析計及び質量分析方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005522845A (ja) * 2002-04-05 2005-07-28 エムディーエス　インコーポレイテッド　ドゥーイング　ビジネス　アズ　エムディーエス　サイエックス 高次の多重極電界、低圧イオン・トラップ内での共振励起によるイオンのフラグメンテーション
JP2011023184A (ja) * 2009-07-15 2011-02-03 Hitachi High-Technologies Corp 質量分析計及び質量分析方法

Also Published As

Publication number Publication date
JP2024029800A (ja) 2024-03-07

Similar Documents

Publication Publication Date Title
US9761427B2 (en) System for transferring ions in a mass spectrometer
US9601323B2 (en) Ion transport apparatus and mass spectrometer using the same
US9773656B2 (en) Ion transport apparatus and mass spectrometer using the same
US7514673B2 (en) Ion transport device
US10062558B2 (en) Mass spectrometer
US7915580B2 (en) Electro-dynamic or electro-static lens coupled to a stacked ring ion guide
US7582861B2 (en) Mass spectrometer
US8907272B1 (en) Radio frequency device to separate ions from gas stream and method thereof
JP6458128B2 (ja) イオンガイド及びそれを用いた質量分析装置
US9177775B2 (en) Mass spectrometer
JP5673848B2 (ja) 質量分析装置
JP5644863B2 (ja) イオンガイド及び質量分析装置
KR20200132881A (ko) 성능 및 서비스 수명이 개선된 입자 검출기
CN110612595B (zh) 离子检测装置及质谱分析装置
WO2024042908A1 (fr) Guide d'ions et dispositif de spectrométrie de masse le comprenant
JP7127701B2 (ja) 質量分析装置
JP6759321B2 (ja) 多重極イオンガイド
WO2024014208A1 (fr) Guide d'ions et spectromètre de masse
JP7073459B2 (ja) イオンガイド及びそれを用いた質量分析装置
US20240071739A1 (en) Geometries for radio-frequency multipole ion guides
JP2024035903A (ja) 質量分析装置
JP2023100094A (ja) 質量分析装置
GB2402807A (en) Mass spectrometer
GB2583311A (en) Ion guide and mass spectrometer using same

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 23855841

Country of ref document: EP

Kind code of ref document: A1