WO2024001406A1 - 采样检测装置 - Google Patents

采样检测装置 Download PDF

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Publication number
WO2024001406A1
WO2024001406A1 PCT/CN2023/087291 CN2023087291W WO2024001406A1 WO 2024001406 A1 WO2024001406 A1 WO 2024001406A1 CN 2023087291 W CN2023087291 W CN 2023087291W WO 2024001406 A1 WO2024001406 A1 WO 2024001406A1
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WO
WIPO (PCT)
Prior art keywords
test paper
inner cylinder
installation
containing cavity
reaction liquid
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Application number
PCT/CN2023/087291
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English (en)
French (fr)
Inventor
杨标
陈任远
王馨
金巍
刘中华
王国强
Original Assignee
江苏硕世生物科技股份有限公司
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Application filed by 江苏硕世生物科技股份有限公司 filed Critical 江苏硕世生物科技股份有限公司
Publication of WO2024001406A1 publication Critical patent/WO2024001406A1/zh

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips

Definitions

  • the present invention relates to the field of biological detection, and in particular, to a sampling detection device.
  • the principle of immunochromatography is to first fix a specific antibody on a certain zone of the nitrocellulose membrane. When one end of the dry nitrocellulose is immersed in the sample, the sample will move forward along the membrane due to capillary action. , when moving to the area where the antibody is fixed, the corresponding antigen in the sample will specifically bind to the antibody. If immunocolloidal gold or immunoenzyme staining is used, the area can show a certain color, thereby achieving specific immunodiagnosis. .
  • the existing Chinese patent application document with publication number CN208705337U discloses a sampling and detection device including: an upper card, a row card provided with a vent hole, a visual window and a sampling hole, and multiple sampling holes are provided; a lower card , the lower card and the upper card are arranged relative to each other, an accommodation space is formed between the lower card and the upper card, and the accommodation space is connected with the ventilation hole; the detection test paper is located inside the accommodation space, and the detection test paper is set to multiple, among the multiple detection test strips The intervals between the test strips are set relative to each other, and each test strip is set relative to the viewing window, and each test strip is set relative to at least one sampling hole.
  • sampling detection device When the sampling detection device in the prior art performs detection, staff are required to add samples to at least one sampling hole. The operation is complex, the batch detection efficiency is poor, and there are areas for improvement.
  • the purpose of the present invention is to provide a sampling detection device.
  • a sampling and detection device includes an outer cylinder, an inner cylinder and a cylinder cover.
  • the outer cylinder includes a reaction liquid containing chamber and a main body containing chamber arranged sequentially from bottom to top.
  • the reaction liquid containing chamber It is connected with the main body accommodating cavity, and one end of the main body accommodating cavity away from the reaction liquid accommodating cavity is open, and the side wall of the main body accommodating cavity includes a transparent structure;
  • the inner cylinder includes an extrusion part and a test strip installation part connected in sequence, so The test paper installation part is provided with a plurality of test paper installation positions around the circumference;
  • the outer cylinder accommodates the inner cylinder, the test paper installation part is located in the main body accommodation cavity, the extrusion part penetrates into the reaction liquid accommodation cavity, and the The extrusion part cooperates with the inner wall of the reaction liquid containing chamber to form a gap that allows the reaction liquid to pass;
  • the cylinder cover is detachably connected to the outer cylinder, and the cylinder cover closes or opens the
  • a flow guide groove is provided on the outer wall of the extrusion part, and the flow guide groove extends from an end of the extrusion part away from the test paper installation part in a direction close to the test paper installation part.
  • test paper installation position is recessed on the outer wall of the test paper installation part, and a limited rib is provided at an opening edge of the test paper installation position.
  • a pressing piece is provided inside the cylinder cover.
  • the pressing piece abuts against the inner cylinder.
  • the inner cylinder includes a hollow structure, and the inner cylinder includes an integrated structure or a split structure.
  • test strip installation part includes an installation body and a connection seat, the installation body and the connection seat are plug-connected, and the end of the connection seat away from the installation body is tightly connected to the extrusion part.
  • a guide groove is provided on the outer wall of the extrusion part, and an overflow opening is provided at one end of the connecting seat close to the extrusion part, and the overflow opening communicates with the guide groove and the internal space of the inner cylinder;
  • a first conductive hole is provided on one side of the test strip installation position at the connection base, and the first conductive hole connects the test strip installation position and the internal space of the inner cylinder.
  • test strip installation part includes a plurality of installation side plates, and any two adjacent installation side plates are snap-connected.
  • a clamping block is provided at the bottom of any of the installation side plates, and the plurality of clamping blocks at the bottom of the test paper installation part cooperates with the clamping and extruding part.
  • a second conductive hole is opened on a side of the test paper installation position close to the extrusion part, and the second conductive hole connects the test paper installation position and the internal space of the inner cylinder.
  • Figure 1 is an exploded schematic diagram of the overall structure of the sampling detection device in Embodiment 1 of the present invention.
  • Figure 2 is a schematic cross-sectional structural diagram of the overall structure of the sampling detection device in Embodiment 1 of the present invention.
  • Figure 3 is a schematic cross-sectional structural diagram of the overall structure of the sampling and detection device in Embodiment 2 of the present invention.
  • Figure 4 is a top view of the inner cylinder structure in Embodiment 2 of the present invention.
  • Figure 5 is an exploded schematic diagram of the overall structure of the sampling and detection device in Embodiment 3 of the present invention.
  • Figure 6 is a schematic isometric view of the explosion structure of the sampling detection device in Embodiment 3 of the present invention.
  • Figure 7 is a top view of the inner cylinder structure in Embodiment 3 of the present invention.
  • a sampling detection device provided according to the present invention includes an outer cylinder 1, an inner cylinder 2 and a cylinder cover 3.
  • the outer cylinder 1 can accommodate the reaction solution, and the outer wall of the inner cylinder 2 has multiple test paper installation positions 4.
  • the detection test paper can be firmly installed on the test paper installation positions 4, and during installation, ensure that the chromatography part of the detection test paper is located at the test paper installation position 4.
  • multiple test strips with different antibodies can be installed in multiple test strip installation positions 4 respectively, the sampling swabs are inserted into the outer cylinder 1, and the reaction liquid in the outer cylinder 1 is used to wash the sampling swabs.
  • the bottom structure of the inner cylinder 2 raises the liquid level of the liquid in the outer cylinder 1, so that the liquid in the outer cylinder 1 can immerse the chromatography parts of multiple test strips. This enables multi-link detection with simple structure and easy operation.
  • the outer cylinder 1 can be an integrated structure.
  • the outer cylinder 1 includes a reaction liquid containing chamber 11 and a main body containing chamber 12 arranged sequentially from bottom to top.
  • the reaction liquid containing chamber 11 and the main body containing chamber 12 are connected, and the main body containing chamber 12 is far away from each other.
  • One end of the reaction liquid containing chamber 11 is open.
  • the side wall of the main body receiving cavity 12 includes a transparent structure. More specifically, the outer cylinder 1 is made of transparent material.
  • the inner cylinder 2 may be of an integrated structure, the inner cylinder 2 may be of a hollow structure, and the upper end of the inner cylinder 2 may be open.
  • the staff can put the eluted sampling swab into the inner cylinder 2, which can prevent the sampling swab from contaminating the environment.
  • the inner cylinder 2 includes a pressing part 21 and a test paper installation part 23 which are connected in sequence.
  • a plurality of test paper installation positions 4 are provided around the test paper installation part 23 . Any test paper installation position 4 can securely install a piece of detection test paper.
  • the test paper installation position 4 is recessed on the outer wall of the test paper installation part 23 , and the opening edge of the test paper installation position 4 is integrally formed with a limited rib 5 .
  • This application takes eight test paper installation positions 4 on the test paper installation part 23 as an example to illustrate: the eight test paper installation positions 4 are arranged at equal intervals around the test paper installation part 23, and the shapes of the eight test paper installation positions 4 are all long. In a strip shape, the length direction of the eight test paper installation positions 4 is parallel to the length direction of the inner cylinder 2, and the dimensions of the eight test paper installation positions 4 in a row are all the same. There is one limit rib 5 integrally formed at the opening edges on both sides of the width of any test paper installation position 4. The length direction of any limit rib 5 is parallel to the length direction of the inner cylinder 2, and any limit rib 5 is parallel to the length direction of the inner cylinder 2.
  • the edges 5 extend from the opening edge of the test paper installation position 4 to above the test paper installation position 4, so that the test paper can be firmly installed on the test paper installation position 4, thereby reducing the accidental falling off of the test paper. And when installing the test strips on the eight test strip installation positions 4, it can be ensured that the eight test strips are located at the same height.
  • the outer cylinder 1 can accommodate the inner cylinder 2
  • the test strip installation part 23 is located in the main body accommodation chamber 12
  • the extrusion part 21 penetrates into the reaction liquid accommodation chamber 11, and the extrusion part 21 is in contact with the reaction liquid accommodation chamber 11.
  • the inner wall of the liquid containing chamber 11 cooperates to form a gap that allows the reaction liquid to pass.
  • the shape of the extruding part 21 matches the shape of the reaction liquid accommodating chamber 11, so that the extruding part 21 can discharge all the liquid in the reaction liquid accommodating chamber 11 as much as possible.
  • both the squeezing part 21 and the reaction liquid containing chamber 11 can be set in a cylindrical shape, and the size of the squeezing part 21 is slightly smaller than the size of the reaction liquid containing chamber 11, so that the squeezing part 21 can penetrate into the reaction liquid containing chamber. into the cavity 11 and drain the liquid therein.
  • the shapes of the extruding part 21 and the reaction liquid containing cavity 11 may be regular shapes or irregular shapes, as long as the extruding part 21 can penetrate into the reaction liquid containing cavity 11 .
  • a guide groove 22 may be provided on the outer wall of the extrusion part 21 .
  • the guide groove 22 extends from an end of the extrusion part 21 away from the test paper installation part 23 to a direction close to the test paper installation part 23 .
  • the liquid in the reaction liquid containing chamber 11 can be discharged more easily with the help of the guide groove 22 .
  • the barrel cover 3 is detachably connected to the outer barrel 1 , and the barrel cover 3 closes or opens the open side of the main body receiving cavity 12 .
  • the detachable connection method may be a threaded connection, a plug connection, or other connection methods commonly used in the prior art.
  • a pressing piece 6 is embedded inside the cylinder cover 3. When the cylinder cover 3 is installed on the outer cylinder 1, the pressing piece 6 contacts the inner cylinder 2.
  • the pressing piece 6 can be made of rubber material. On the one hand, it can prevent the liquid in the outer cylinder 1 from flowing out from the connection between the outer cylinder 1 and the cylinder cover 3; on the other hand, the pressing piece 6 is used to limit the axial position of the inner cylinder 2, reducing the freedom of movement of the inner cylinder 2. , then Observe test results on staff.
  • the multi-joint inspection device of this application is especially suitable for the following scenarios:
  • Respiratory tract swabs After the sampling is completed, place the sampling swab in the reaction solution holding chamber 11 at the bottom of the outer tube and elute it, then discard the sampling swab into the inner cylinder 2, and put the inner cylinder 2 into the outer cylinder 1.
  • Complete Chromatography can complete common combinations of respiratory pathogens such as FLUA/FLUB/RSV/ADV/RV/HPIVs/MP/ncov-19.
  • Fecal sample type After collecting the fecal sample with the sampling spoon, place it in the reaction solution holding chamber 11 at the bottom of the outer tube. After thorough mixing, insert the inner tube into the outer cylinder 1 to complete chromatography, which can complete common HRV/ADV/ Norovirus/HP/calcium guard/occult blood and other multiple indicator combinations.
  • Blood and urine samples The liquid can be collected and dropped directly into the reaction solution holding chamber 11 at the bottom of the outer cylinder 1. After thorough mixing, insert the inner cylinder 2 into the outer cylinder 1 to complete the chromatography. It can be used For detection of common blood source indicators.
  • This device can be applied to multiple detection scenarios to achieve rapid detection of multiple targets in one sampling. It is simple and fast, with result interpretation in 15 minutes. It can achieve sample input and result output. Moreover, the sampling waste is sealed in the detection device and does not cause pollution to the environment.
  • the inner cylinder 2 may have a split structure.
  • the test strip installation part 23 includes an installation body 71 and a connection base 72.
  • the installation body 71 and the connection base 72 are plug-connected.
  • the end of the connection base 72 away from the installation body 71 is tightly connected to the extrusion part 21.
  • Fixed connection Specifically, one end of the connecting seat 72 close to the installation body 71 is integrally formed with a plug-in shaft, and one end of the installation main body 71 close to the connecting seat 72 is provided with a plug-in interface.
  • the plug-in interface is provided between any two adjacent test strip installation positions 4 There is a one-to-one correspondence and plug-in fit between the plug-in shaft and the plug-in interface, thereby realizing the split connection of the test paper installation part 23, thereby improving the convenience of installing the test paper on the test paper installation position 4, and the structure is simple and convenient. manufacture.
  • the plug-in shaft includes a positioning section and a fixed section.
  • the positioning section cooperates with the plug-in interface to realize the positioning between the connection base 72 and the installation body 71 .
  • the fixed section cooperates with the plug-in interface to realize the positioning between the connection base 72 and the installation main body 71 . Tighten the connection.
  • the outer wall of the extrusion part 21 is provided with a guide groove 22
  • the connecting seat 72 is provided with an overflow opening 75 at one end close to the extrusion part 21 .
  • the overflow opening 75 communicates with the guide groove 22 and the internal space of the inner cylinder 2 .
  • the liquid in the outer cylinder 1 can flow into the internal space of the inner cylinder 2 along the guide groove 22 and the overflow port 75 .
  • the test paper installation position 4 is provided with a first conductive hole 76 on one side of the connection base 72.
  • the first conductive hole 76 connects the test paper installation position 4 and the internal space of the inner cylinder 2, so that the liquid can be immersed in the detection test paper from both sides.
  • the chromatography part of the test paper ensures the chromatography effect and chromatography speed.
  • this embodiment when this embodiment is used for respiratory swab detection, after the sampling swab is eluted in the reaction liquid holding chamber 11, the staff places the sampling end of the sampling swab downwards in the inner cylinder 2, and then Then put the inner cylinder 2 into the outer cylinder 1, the extrusion part 21 squeezes out the liquid in the reaction liquid containing chamber 11, and the liquid enters the inner cylinder 2, the inner cylinder 2 and the outer cylinder along the guide groove 22 and the overflow port 75. in the gap of barrel 1. The liquid entering the inner cylinder 2 immerses the sampling end of the sampling swab, which can prevent detection errors caused by incomplete elution of the sampling swab and improve the accuracy of detection.
  • the inner cylinder 2 may have a split structure.
  • the test strip installation part 23 includes a plurality of installation side plates 81 , and any two adjacent installation side plates 81 are snap-connected.
  • the shape of the test strip mounting portion 23 may be a regular shape such as a rectangular shape or a cylindrical shape, or may be an irregular shape. Among them, a feasible implementation method is that the shape of the test paper installation part 23 is rectangular.
  • the test paper installation part 23 includes four installation side plates 81, and two test paper installation positions 4 are provided on the outer wall of any installation side plate 81.
  • any installation side plate 81 has a snap-in block 82 on one side and a snap-in slot 83 on the other side.
  • the snap-in block 82 on any installation side panel 81 is the same as the snap-on block 82 on the adjacent installation side panel 81 .
  • the snap-in slot 83 is snap-connected, thereby realizing the overall assembly of the test strip installation part 23 .
  • any installation side plate 81 is integrally formed with a clamping block 84 , and the four clamping blocks 84 at the bottom of the test paper installation part 23 cooperate to clamp the extrusion part 21 .
  • the extrusion part 21 is cylindrical, and the shape of the contact part between the clamping block 84 and the extrusion part 21 is a quarter arc with the same arc as the extrusion part 21, so that the four clamping blocks 84 can cooperate stably.
  • the pressing part 21 is clamped to realize the assembly of the inner cylinder 2 .
  • a second conductive hole 85 is opened on the side of the test paper installation position 4 close to the extrusion part 21 , and the second conduction hole 85 connects the test paper installation position 4 and the internal space of the inner cylinder 2 .
  • the present invention has the following beneficial effects:
  • multiple detection test papers are installed at multiple detection test paper installation positions on the outer wall of the inner cylinder, and the reaction liquid is placed in the outer cylinder. After sampling, the sample is added to the reaction liquid containing chamber, and the reaction liquid is placed in the reaction liquid containing chamber. Mix thoroughly inside, then put the inner cylinder into the outer cylinder, and the squeeze part of the inner cylinder squeezes the liquid in the reaction liquid holding chamber into The main body contains the cavity, and the liquid immerses the chromatographic parts of multiple test strips, and waits for a certain period of time before judging the results to complete the multiplex detection. It has a simple structure, easy operation, and high batch detection efficiency.
  • the present invention provides a guide groove in the extrusion part, so that when the extrusion part extends into the reaction liquid accommodating cavity, the liquid flows from the reaction liquid accommodating cavity into the main body accommodating cavity, and the extrusion part and the reaction liquid accommodating cavity cooperate with each other. Efficiently utilize the reaction solution, reduce ineffective liquid, and improve sample utilization.
  • the staff can put sampling instruments (such as sampling swabs, etc.) into the inner cylinder, and the entire detection process Completed in a closed environment, it can effectively prevent samples in the reaction liquid holding chamber and residual samples from the sampling equipment from polluting the environment, enhance environmental safety, and reduce the risk of operator infection.
  • the liquid entering the inner cylinder immerses the sampling end of the sampling equipment, which can prevent contamination of the environment. Detection errors caused by incomplete elution from sampling equipment can help improve detection accuracy.

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
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  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
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  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

本发明提供了一种采样检测装置，包括外筒、内筒以及筒盖，外筒包括反应液容纳腔和主体容纳腔，反应液容纳腔和主体容纳腔连通，主体容纳腔的一端敞开，主体容纳腔的侧壁包括透明结构；内筒包括挤压部和试纸安装部；外筒容置内筒，所述试纸安装部位于主体容纳腔内，挤压部探入反应液容纳腔内，且挤压部与反应液容纳腔的内壁配合形成有间隙；筒盖与外筒可拆卸式连接，且筒盖封闭或打开主体容纳腔的敞开侧。采样时，将采样拭子在外筒内洗脱，将内筒放入外筒中，内筒的挤压部将反应液容纳腔内的液体挤出，液体将多个检测试纸的层析部浸没，之后再进行结果判断，完成多联检测，且结构简单，操作方便，批量检测效率高。

Description

采样检测装置 技术领域
本发明涉及生物检测领域，具体地，涉及一种采样检测装置。
背景技术
免疫层析法的原理是将特异的抗体先固定于硝酸纤维素膜的某一区带，当该干燥的硝酸纤维素的一端浸入样品后，由于毛细管作用，样品将沿着该膜向前移动，当移动至固定有抗体的区域时，样品中相应的抗原即与该抗体发生特异性结合，若用免疫胶体金或免疫酶染色可使该区域显示一定的颜色，从而实现特异性的免疫诊断。
现有公开号为CN208705337U的中国专利申请文献，其公开了一种采样检测装置包括：上卡，行卡上设置有通气孔、可视窗以及加样孔，加样孔设置为多个；下卡，下卡和上卡相对设置，下卡和上卡之间形成容纳空间，容纳空间和通气孔连通；检测试纸，检测试纸位于容纳空间的内部，检测试纸设置为多个，多个检测试纸之间间隔设置，检测试纸和可视窗相对设置，每个检测试纸和至少一个加样孔相对设置。
现有技术中的采样检测装置进行检测时，需要工作人员对至少一个加样孔进行加样，操作复杂，批量检测效率差，存在待改进之处。
发明内容
针对现有技术中的缺陷，本发明的目的是提供一种采样检测装置。
根据本发明的实施例提供的一种采样检测装置,包括外筒、内筒以及筒盖，所述外筒包括自下向上依次设置的反应液容纳腔和主体容纳腔，所述反应液容纳腔和主体容纳腔连通，所述主体容纳腔远离反应液容纳腔的一端敞开，且所述主体容纳腔的侧壁包括透明结构；所述内筒包括依次连接的挤压部和试纸安装部，所述试纸安装部的周测设置有多个试纸安装位；所述外筒容置内筒，所述试纸安装部位于主体容纳腔内，所述挤压部探入反应液容纳腔内，且所述挤压部与反应液容纳腔的内壁配合形成有允许反应液通过的间隙；所述筒盖与外筒可拆卸式连接，且所述筒盖封闭或打开主体容纳腔的敞开 侧。
进一步地，所述挤压部的外壁上开设有导流槽，所述导流槽自挤压部远离试纸安装部的一端向靠近试纸安装部的方向延伸。
进一步地，所述试纸安装位在试纸安装部的外壁上呈凹陷设置，且所述试纸安装位的开口边缘位置设置有限位挡边。
进一步地，所述筒盖内部设置有压片，当所述筒盖在外筒上安装到位后，所述压片与内筒抵接。
进一步地，所述内筒包括中空结构，且所述内筒包括一体式结构或分体式结构。
进一步地，所述试纸安装部包括安装主体和连接座，所述安装主体和连接座二者插接连接，所述连接座远离安装主体的一端与挤压部紧固连接。
进一步地，所述挤压部的外壁上开设有导流槽，所述连接座靠近挤压部的一端开设有溢流口，所述溢流口连通导流槽和内筒的内部空间；所述试纸安装位位于连接座的一侧开设有第一导通孔，所述第一导通孔连通试纸安装位和内筒的内部空间。
进一步地，所述试纸安装部包括多个安装侧板，任意相邻的两个所述安装侧板均卡接连接。
进一步地，任一所述安装侧板的底部均设置有夹持块，所述试纸安装部底部的多个夹持块配合夹持挤压部。
进一步地，所述试纸安装位靠近挤压部的一侧开设有第二导通孔，所述第二导通孔连通试纸安装位和内筒的内部空间。
附图说明
通过阅读参照以下附图对非限制性实施例所作的详细描述，本发明的其它特征、目的和优点将会变得更明显：
图1为本发明实施例一中采样检测装置整体结构的爆炸示意图；
图2为本发明实施例一中采样检测装置整体结构的剖面结构示意图；
图3为本发明实施例二中采样检测装置整体结构的剖面结构示意图；
图4为本发明实施例二中内筒结构的俯视图；
图5为本发明实施例三中采样检测装置整体结构的爆炸示意图；
图6为本发明实施例三中采样检测装置爆炸结构的轴测示意图；
图7为本发明实施例三中内筒结构的俯视图。
图中所示：
外筒1                  压片6
反应液容纳腔11         安装主体71
主体容纳腔12           连接座72
内筒2                  溢流口75
挤压部21               第一导通孔76
导流槽22               安装侧板81
试纸安装部23           卡接块82
筒盖3                  卡接槽83
试纸安装位4            夹持块84
限位挡边5              第二导通孔85
具体实施方式
下面结合具体实施例对本发明进行详细说明。以下实施例将有助于本领域的技术人员进一步理解本发明，但不以任何形式限制本发明。应当指出的是，对本领域的普通技术人员来说，在不脱离本发明构思的前提下，还可以做出若干变化和改进。这些都属于本发明的保护范围。
实施例一
如图1和图2所示，根据本发明提供的一种采样检测装置，包括外筒1、内筒2以及筒盖3。外筒1能够容纳反应液，内筒2的外壁上具有多个试纸安装位4，检测试纸可以紧固安装在试纸安装位4上，且安装时保证检测试纸的层析部位于试纸安装位4靠近内筒2底部的一侧。进行多联检测时，可以将具有不同抗体的多个检测试纸分别安装到多个试纸安装位4，将采样拭子伸入外筒1内，利用外筒1内的反应液将采样拭子洗脱，然后将内筒2放入外筒1内，内筒2的底部结构将外筒1内液体的液位抬高，使外筒1内的液体能够浸没多个检测试纸的层析部，进而实现多联检测，且结构简单、操作方便。
具体地，外筒1可以是一体式结构，外筒1包括自下向上依次设置的反应液容纳腔11和主体容纳腔12，反应液容纳腔11和主体容纳腔12连通，主体容纳腔12远离反应液容纳腔11的一端敞开。且主体容纳腔12的侧壁包括透明结构，更为具体地，外筒1由透明材料制成。
内筒2可以是一体式结构，内筒2为中空结构，内筒2的上端敞开。在进行多联检测时，工作人员可以将洗脱后的采样拭子放入内筒2中，能够防止采样拭子污染环境。内筒2包括依次连接的挤压部21和试纸安装部23，试纸安装部23的周测设置有多个试纸安装位4。任一试纸安装位4均可以紧固安装一片检测试纸。试纸安装位4在试纸安装部23的外壁上呈凹陷设置，且试纸安装位4的开口边缘位置一体成型有限位挡边5。
本申请以试纸安装部23上具有八个试纸安装位4为例进行阐述：八个试纸安装位4在试纸安装部23的周侧呈等间隔设置，八个试纸安装位4的形状均为长条形，八个试纸安装位4的长度方向均与内筒2的长度方向平行，且行八个试纸安装位4的尺寸均相同。限位挡边5在任一试纸安装位4宽度两侧的开口边缘位置均一体成型有一个，任一限位挡边5的长度方向均与内筒2的长度方向平行，且任一限位挡边5均自试纸安装位4的开口边缘位置向该试纸安装位4的上方延伸，从而使检测试纸能够紧固安装在试纸安装位4上，减少检测试纸意外脱落的情况发生。且八个试纸安装位4上的检测试纸在安装时，可以保证八个检测试纸位于同一高度。
如图1和图2所示，外筒1能够容置内筒2，试纸安装部23位于主体容纳腔12内，挤压部21探入反应液容纳腔11内，且挤压部21与反应液容纳腔11的内壁配合形成有允许反应液通过的间隙。挤压部21的形状和反应液容纳腔11的形状相匹配，使挤压部21能够尽可能的将反应液容纳腔11内的液体全部排出。例如，可以将挤压部21和反应液容纳腔11二者均设置为圆柱形，挤压部21的尺寸略小于反应液容纳腔11的尺寸，从而使挤压部21能够探入反应液容纳腔11内并将其中的液体排出。需要明确的是，挤压部21和反应液容纳腔11二者的形状可以是规则形状、也可以是不规则形状，只需要满足挤压部21能够探入反应液容纳腔11内即可。
进一步地，挤压部21的外壁上可以开设有导流槽22，导流槽22自挤压部21远离试纸安装部23的一端向靠近试纸安装部23的方向延伸。借助导流槽22能够使反应液容纳腔11内的液体更容易排出。
更为具体地，筒盖3与外筒1可拆卸式连接，且筒盖3封闭或打开主体容纳腔12的敞开侧。可拆卸连接的方式可以是螺纹连接、插接等现有技术中常用的连接方式。筒盖3内部嵌设安装有压片6，当筒盖3在外筒1上安装到位后，压片6与内筒2抵接，压片6可以采用橡胶材质。一方面可以防止外筒1内的液体，自外筒1与筒盖3的连接处流出；另一方面利用压片6对内筒2的轴向进行限位，减少内筒2的运动自由度，便 于工作人员观检测结果。
本申请的多联检装置尤其是适用于如下场景：
1、呼吸道拭子类：采样完成后将采样拭子在外管底端的反应液容纳腔11内洗脱后，将采样拭子弃置于内筒2，并将内筒2放入外筒1，完成层析，可完成常见的FLUA/FLUB/RSV/ADV/RV/HPIVs/MP/ncov-19等呼吸道病原体组合。
2、粪便样本类型：采样勺采集粪便样本后置于外管底部的反应液容纳腔11内，充分混匀后，将内管插入外筒1，完成层析，可完成常见的HRV/ADV/Norovirus/HP/钙卫/隐血等多指标组合。
3、血液、尿液样本类：可将液体采集后直接滴加到外筒1底部的反应液容纳腔11内，充分混匀后，将内筒2插入外筒1内，完成层析，可用于常见的血源类指标检测。
本装置可应用于多检测场景，实现一次采样多靶标快速检测，简单快速，15min结果判读，可实现样本进，结果出。并且采样废弃物均密封在检测装置中，不对环境造成污染。
实施例二
基于实施例一，根据本发明提供的一种采样检测装置，内筒2可以是分体式结构。
如图3和图4所示，试纸安装部23包括安装主体71和连接座72，安装主体71和连接座72二者插接连接，连接座72远离安装主体71的一端与挤压部21紧固连接。具体地，连接座72靠近安装主体71的一端一体成型有插接轴，安装主体71靠近连接座72的一端开设有插接口，插接口在任一两个相邻的试纸安装位4之间均开设有一个，插接轴与插接口一一对应且插接配合，从而实现了试纸安装部23的分体式连接，进而提高了检测试纸在试纸安装位4上安装的便捷性，且结构简单，便于制造。
再进一步地，插接轴包括定位段和固定段，定位段与插接口配合实现连接座72与安装主体71之间的定位，固定段与插接口配合实现连接座72和安装主体71之间的紧固连接。
挤压部21的外壁上开设有导流槽22，连接座72靠近挤压部21的一端开设有溢流口75，溢流口75连通导流槽22和内筒2的内部空间。外筒1内的液体能够沿着导流槽22和溢流口75流入内筒2的内部空间内。试纸安装位4位于连接座72的一侧开设有第一导通孔76，第一导通孔76连通试纸安装位4和内筒2的内部空间，使液体能够从检测试纸的两侧浸没检测试纸的层析部，从而保证层析效果和层析速率。
特别地，当本实施方案用于呼吸道拭子类采用检测时，采样拭子在反应液容纳腔11内洗脱后，工作人员将采样拭子的采样端向下放置在内筒2中，之后再将内筒2放入外筒1中，挤压部21将反应液容纳腔11内的液体挤出，液体沿着导流槽22和溢流口75进入内筒2、内筒2和外筒1的间隙中。进入内筒2的液体浸没采样拭子的采样端，能够防止对采样拭子洗脱不完全导致的检测误差，提高了检测的准确性。
实施例三
基于实施例一，根据本发明提供的一种采样检测装置，内筒2可以是分体式结构。
如图5、图6以及图7所示，试纸安装部23包括多个安装侧板81，任意相邻的两个安装侧板81均卡接连接。试纸安装部23的形状可以是矩形、圆柱形等规则形状，也可以是不规则形状。其中，一种可行的实施方式为试纸安装部23的形状呈矩形，试纸安装部23包括四块安装侧板81，任一块安装侧板81的外侧壁上均设置有两个试纸安装位4，且任一安装侧板81的一侧均具有卡接块82、另一侧均具有卡接槽83，任一安装侧板81上的卡接块82均与其相邻的安装侧板81上的卡接槽83卡接连接，从而实现试纸安装部23整体的组装。
进一步地，任一安装侧板81的底部均一体成型有夹持块84，试纸安装部23底部的四个夹持块84配合夹持挤压部21。例如，挤压部21呈圆柱形，夹持块84与挤压部21接触部分的形状为与挤压部21弧度相同的四分之一圆弧，从而使四个夹持块84配合能够稳定夹持挤压部21，实现内筒2的组装。试纸安装位4靠近挤压部21的一侧开设有第二导通孔85，第二导通孔85连通试纸安装位4和内筒2的内部空间。
在本申请的描述中，需要理解的是，术语“上”、“下”、“前”、“后”、“左”、“右”、“竖直”、“水平”、“顶”、“底”、“内”、“外”等指示的方位或位置关系为基于附图所示的方位或位置关系，仅是为了便于描述本申请和简化描述，而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本申请的限制。
与现有技术相比，本发明具有如下的有益效果：
1、本发明通过将多个检测试纸分别安装在内筒外壁上的多个检测试纸安装位上，将反应液放置在外筒内，采样后，将样本加入反应液容纳腔，在反应液容纳腔内充分混匀，然后将内筒放入外筒中，内筒的挤压部将反应液容纳腔内的液体挤入 主体容纳腔内，且液体将多个检测试纸的层析部浸没，等待一定时间再进行结果判断，完成多联检测，且结构简单，操作方便，批量检测效率高。
2、本发明通过在挤压部设置导流槽，便于挤压部伸入反应液容纳腔时，液体自反应液容纳腔流入主体容纳腔内，通过挤压部与反应液容纳腔相互配合，高效的利用反应液，减少无效液体，提高样本利用率。
3、本发明通过将内筒设置位为中空结构，并使内筒的上端敞开，在进行多联检测时，工作人员可以将采样器具(如采样拭子等)放入内筒中，整个检测过程在密闭环境内完成，能够有效防止反应液容纳腔内样本及采样器具残留样本造成污染环境，增强环境安全，降低操作人员感染风险，且进入内筒的液体浸没采样器具的采样端，能够防止对采样器具洗脱不完全导致的检测误差，有助于提高检测的准确性。
以上对本发明的具体实施例进行了描述。需要理解的是，本发明并不局限于上述特定实施方式，本领域技术人员可以在权利要求的范围内做出各种变化或修改，这并不影响本发明的实质内容。在不冲突的情况下，本申请的实施例和实施例中的特征可以任意相互组合。

Claims (10)

  1. 一种采样检测装置，其特征在于，包括外筒(1)、内筒(2)以及筒盖(3)，所述外筒(1)包括依次设置的反应液容纳腔(11)和主体容纳腔(12)，所述反应液容纳腔(11)和主体容纳腔(12)连通，所述主体容纳腔(12)远离反应液容纳腔(11)的一端敞开，且所述主体容纳腔(12)的侧壁包括透明结构；
    所述内筒(2)包括依次连接的挤压部(21)和试纸安装部(23)，所述试纸安装部(23)的周测设置有多个试纸安装位(4)；
    所述外筒(1)容置内筒(2)，所述试纸安装部(23)位于主体容纳腔(12)内，所述挤压部(21)探入反应液容纳腔(11)内，且所述挤压部(21)与反应液容纳腔(11)的内壁配合形成有允许反应液通过的间隙；
    所述筒盖(3)与外筒(1)可拆卸式连接，且所述筒盖(3)封闭或打开主体容纳腔(12)的敞开侧。
  2. 如权利要求1所述的采样检测装置，其特征在于，所述挤压部(21)的外壁上开设有导流槽(22)，所述导流槽(22)自挤压部(21)远离试纸安装部(23)的一端向靠近试纸安装部(23)的方向延伸。
  3. 如权利要求1所述的采样检测装置，其特征在于，所述试纸安装位(4)在试纸安装部(23)的外壁上呈凹陷设置，且所述试纸安装位(4)的开口边缘位置设置有限位挡边(5)。
  4. 如权利要求1所述的采样检测装置，其特征在于，所述筒盖(3)内部设置有压片(6)，当所述筒盖(3)在外筒(1)上安装到位后，所述压片(6)与内筒(2)抵接。
  5. 如权利要求1所述的采样检测装置，其特征在于，所述内筒(2)包括中空结构，所述内筒(2)的上端敞开，且所述内筒(2)包括一体式结构或分体式结构。
  6. 如权利要求5所述的采样检测装置，其特征在于，所述试纸安装部(23)包括安装主体(71)和连接座(72)，所述安装主体(71)和连接座(72)二者插接连接，所述连接座(72)远离安装主体(71)的一端与挤压部(21)紧固连接。
  7. 如权利要求6所述的采样检测装置，其特征在于，所述挤压部(21)的外壁上开设有导流槽(22)，所述连接座(72)靠近挤压部(21)的一端开设有溢流口(75)，所述溢流口(75)连通导流槽(22)和内筒(2)的内部空间；
    所述试纸安装位(4)位于连接座(72)的一侧开设有第一导通孔(76)，所述第一 导通孔(76)连通试纸安装位(4)和内筒(2)的内部空间。
  8. 如权利要求5所述的采样检测装置，其特征在于，所述试纸安装部(23)包括多个安装侧板(81)，任意相邻的两个所述安装侧板(81)均卡接连接。
  9. 如权利要求8所述的采样检测装置，其特征在于，任一所述安装侧板(81)的底部均设置有夹持块(84)，所述试纸安装部(23)底部的多个夹持块(84)配合夹持挤压部(21)。
  10. 如权利要求9所述的采样检测装置，其特征在于，所述试纸安装位(4)靠近挤压部(21)的一侧开设有第二导通孔(85)，所述第二导通孔(85)连通试纸安装位(4)和内筒(2)的内部空间。
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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101261230A (zh) * 2007-10-08 2008-09-10 马义才 一种便携式样品快速联检装置
CN201555723U (zh) * 2009-06-25 2010-08-18 益思美诠生物科技(上海)有限公司 集采样反应一体的装置
CN109187959A (zh) * 2018-08-27 2019-01-11 刘小玲 一种个人自测层析试剂检测装置
CN113484514A (zh) * 2021-03-25 2021-10-08 江苏硕世生物科技股份有限公司 试纸检测辅助装置
CN216013389U (zh) * 2021-10-19 2022-03-11 广东不二医疗科技有限公司 抗原笔
CN115327109A (zh) * 2022-06-30 2022-11-11 江苏硕世生物科技股份有限公司 采样检测装置

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105334077B (zh) * 2015-11-26 2019-04-19 浙江东方基因生物制品有限公司 一种流体的快速检测装置
CN108318482A (zh) * 2018-03-07 2018-07-24 广州浩强生物科技有限公司 一种唾液检测装置及其检测方法
CN110018013A (zh) * 2019-03-27 2019-07-16 江苏宝卫士生物科技有限公司 一种医用取样、检测一体化装置
CN212301569U (zh) * 2020-06-22 2021-01-05 新疆医科大学第三附属医院 一种胃肠道肿瘤检测装置
CN215415453U (zh) * 2021-01-21 2022-01-04 浙江东方基因生物制品股份有限公司 一种液体检测装置
CN112858282A (zh) * 2021-03-04 2021-05-28 北京恒基伟业技术开发有限公司 一种全封闭检验尿杯及其应用方法
CN216284948U (zh) * 2021-09-01 2022-04-12 广州朗坤生物科技有限公司 一种采样及检测装置

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101261230A (zh) * 2007-10-08 2008-09-10 马义才 一种便携式样品快速联检装置
CN201555723U (zh) * 2009-06-25 2010-08-18 益思美诠生物科技(上海)有限公司 集采样反应一体的装置
CN109187959A (zh) * 2018-08-27 2019-01-11 刘小玲 一种个人自测层析试剂检测装置
CN113484514A (zh) * 2021-03-25 2021-10-08 江苏硕世生物科技股份有限公司 试纸检测辅助装置
CN216013389U (zh) * 2021-10-19 2022-03-11 广东不二医疗科技有限公司 抗原笔
CN115327109A (zh) * 2022-06-30 2022-11-11 江苏硕世生物科技股份有限公司 采样检测装置

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