WO2023275626A1 - A dietary supplement composition for anti-aging - Google Patents

A dietary supplement composition for anti-aging Download PDF

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Publication number
WO2023275626A1
WO2023275626A1 PCT/IB2022/051526 IB2022051526W WO2023275626A1 WO 2023275626 A1 WO2023275626 A1 WO 2023275626A1 IB 2022051526 W IB2022051526 W IB 2022051526W WO 2023275626 A1 WO2023275626 A1 WO 2023275626A1
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fish
protein hydrolysate
dietary supplement
vitamin
supplement composition
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PCT/IB2022/051526
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French (fr)
Inventor
Kor Seng @ Chan Kok Seng TAN
Bi Fah WONG
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Nexgen Biopharma Research & Innovations Sarl
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Publication of WO2023275626A1 publication Critical patent/WO2023275626A1/en

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A23L33/29—Mineral substances, e.g. mineral oils or clays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/60—Fish, e.g. seahorses; Fish eggs

Definitions

  • the present invention generally relates to a dietary supplement composition for anti-aging.
  • the present invention describes a dietary supplement composition for promoting anti-aging comprising marine organism-derived protein hydrolysates.
  • Aging is a gradual, continuous process of natural change that begins in early adulthood. During early middle age, bodily functions begin to gradually decline. Many attempts have been undertaken to develop therapies and formulations that will lengthen human lifespans, enhance health, and increase quality of life as people age. As only few approaches completely comprehend the basis of ageing and illness, few, if any, of these attempts have yielded superior results to date. It's crucial to understand the causes of ageing and the illnesses that come with it, because as with treating a disease, one must first understand the problem, so that a precise remedy can be applied.
  • aging is caused by accumulation of damage inflicted by reactive oxygen species that will eventually causes cell damage which cannot be repaired by internal mechanism, leading to loss of organ mass and functionality, which ultimately culminates in system dysfunction.
  • Free radical damages contribute to many chronic health problems such as inflammatory diseases, cardiovascular diseases and directly influence the muscle functions and health. Severe chronic diseases are associated with aging such as cardiovascular disease (CVD), diabetic metabolic syndrome and Alzheimer’s disease.
  • CVD cardiovascular disease
  • AD diabetic metabolic syndrome
  • Alzheimer’s disease As the case of oxidative stress inflicted by free radical, the inflammatory response inadvertently disrupts cellular homeostasis.
  • oxidation and inflammatory theory of aging has been proposed, where aging is a loss of homeostasis due to the chronic oxidative stress that affects the regulatory and immune system. Accumulation of oxidative stress and inflammation will induce premature aging that may increase the risk of various diseases related to aging. Therefore, it is vital to address the prevention of these detrimental long-term outcomes as they are afflicting not only the aged but also the middle-age population.
  • Marine organism-derived protein hydrolysates may hold promise as functional foods to promote healthy ageing, metabolic health, and benefit skeletal muscle metabolism in humans.
  • a new approach to promoting health and longevity is to provide a dietary supplement composition which comprises fish- derived protein hydrolysates (FSH) that possesses antioxidant, anti-inflammatory and regenerative properties that will be able to prevent premature aging caused by free radical’s damage and inflammation, specifically on the skin, musculoskeletal and immune system.
  • FSH fish- derived protein hydrolysates
  • An embodiment of the present invention provides a dietary supplement composition for an individual, comprising fish milt protein hydrolysate, fish skin protein hydrolysate, fish muscle protein hydrolysate, coenzyme Q10 and Vitis vinifera extract, characterized in that, combination of the fish milt protein hydrolysate, fish skin protein hydrolysate, fish muscle protein hydrolysate, coenzyme Q10 and Vitis vinifera extract having synergistic effect in increasing antioxidant defense for neutralising free radical.
  • the composition comprises at least 100mg of fish milt protein hydrolysate.
  • the composition comprises at least 100mg of fish skin protein hydrolysate.
  • the composition comprises at least 30mg of fish muscle protein hydrolysate.
  • the composition comprises at least 10mg of coenzyme Q10.
  • the composition comprises at least 10mg of Vitis vinifera extract.
  • said dietary supplement composition further comprising one or more supplemental vitamins selected from the group consisting of vitamin A, vitamin C, vitamin E, vitamin K, thiamine, riboflavin, niacin, vitamin B6, folic acid, vitamin B12, biotin and panthothenic acid.
  • supplemental vitamins selected from the group consisting of vitamin A, vitamin C, vitamin E, vitamin K, thiamine, riboflavin, niacin, vitamin B6, folic acid, vitamin B12, biotin and panthothenic acid.
  • said dietary supplement composition further comprising one or more supplemental vitamins selected from the group consisting of vitamin A, vitamin C, vitamin E, vitamin K, thiamine, riboflavin, niacin, vitamin B6, folic acid, vitamin B12, biotin and panthothenic acid.
  • said dietary supplement composition further comprising one or more supplemental minerals selected from the group consisting of iron, calcium, magnesium, potassium, copper, chromium, zinc, molybdenum, iodine, boron, selenium, manganese, or derivatives thereof.
  • the present invention generally relates to a dietary supplement composition for anti-aging.
  • the present invention describes a dietary supplement composition for promoting anti-aging comprising marine organism-derived protein hydrolysates.
  • the present invention discloses a dietary supplement composition for promoting anti-aging which comprises a combination of three main ingredients which are marine organism-derived protein hydrolysates.
  • Three main components of the composition are derived from fish (fish-derived protein hydrolysates (FPH)) and commercially known as Protimune, Collactive, and NutripeptinTM, further fortified with Coenzyme Q10 (CoQ10) and extract of Vitis vinifera to provide synergy effect in neutralising free radicals at cellular level and reduce age related deteriorations in telomere maintenance, supporting normal metabolic functions, cell regulation and enhance DNA repair in both nuclei and mitochondria.
  • FPH fish-derived protein hydrolysates
  • CoQ10 Coenzyme Q10
  • milt protein hydrolysates which is made of fish milt with 26% DNA.
  • lt is a DNA rich marine-organism extract that are known for its immunostimulant, antioxidant and anti-inflammatory properties.
  • Collactive is skin protein hydrolysates which is made of fish skin and contains 94% collagen and 6% elastin oligopeptide, the two main constituent of the extracellular matrix that provide tensile strength, regulation cell adhesion and direct tissue development.
  • NutripeptinTM is protein hydrolysates which is made of fish muscle protein and contains 80% protein and 888 total amino acids.
  • NutripeptinTM is a marine peptide that has a definite functional effect in reducing the glycaemic index, which results in lower postprandial blood glucose level, which further reduces the risk in developing disorders linked to unhealthy lifestyles such as diabetes and cardiovascular disease.
  • FPH Fish protein hydrolysates
  • the various FPH are breakdown products from the enzymatic conversion of fish proteins into smaller peptides, and normally contain 2-20 AAs.
  • Coenzyme Q10 (CoQ10) (also known as ubiquinone and ubidecarenone) is a fat- soluble vitamin and naturally occurring coenzyme structurally similar to vitamin K. It is involved in electron transport and energy production in the mitochondria. Although found in all human cells, it is present in high concentrations in the heart, kidney, liver and pancreas.
  • CoQ10 serves as a potent antioxidant with potential use as a dietary supplement to protect against related degeneration and has been reported to be capable of improving one’s performance by enhancing the uptake and processing of oxygen in cells. It is also effective for nourishing skin, curing heart disease, and promoting energy. Vitis Vinifera (grapes) extract confer health benefits as they have high antioxidant activities due to their phenolic and flavonoid contents. Resveratrol is also found in grape skin and has protection action on various disorders associated with aging.
  • oxidative stress theory of aging reactive oxygen and nitrogen species (RONS) are produced by several endogenous and exogenous processes and their negative effects are neutralized by antioxidant defenses. Oxidative stress occurs from the imbalance between RONS production and these antioxidant defenses.
  • the oxidative stress theory of aging is based on the hypothesis that age- associated functional losses are due to the accumulation of RONS-induced damages.
  • the dietary supplement composition provides a multifunctional and effective anti-aging management system.
  • the dietary supplement composition for anti-aging of the present invention contains the following: Preferably, the preferred embodiment of the dietary supplement composition comprises at least 100 mg to 500 mg of Protimune (fish milt protein hydrolysates), 100mg to 500 mg of Collactive (fish skin protein hydrolysates), 30 mg to 500mg of NutripeptinTM (fish muscle protein hydrolysates), 10mg to 100mg of Coenzyme Q10 and 10mg to 80mg of Vitis vinifera extract.
  • Protimune fish milt protein hydrolysates
  • Collactive fish skin protein hydrolysates
  • NutripeptinTM fish muscle protein hydrolysates
  • 10mg to 100mg of Coenzyme Q10 and 10mg to 80mg of Vitis vinifera extract.
  • the effective dosage ranges from 200mg per day to 1600mg per day.
  • the preferred method of administration is oral to allow the formulation to be consumed in divided dosages with dosing interval, preferably 2 dosages per day.
  • the dietary supplement compositions are administered daily as dietary or nutritional supplements.
  • the compositions can be taken with or without food.
  • Formulation of the compositions of the invention into a soft gel capsule can be accomplished by many methods known in the art. Often the formulation will include an acceptable carrier, such as an oil, or other suspending or emulsifying agent.
  • compositions of the invention can be formulated with suitable carriers such as starch, sucrose, or lactose in tablets, capsules, solutions, syrups and emulsions.
  • suitable carriers such as starch, sucrose, or lactose in tablets, capsules, solutions, syrups and emulsions.
  • the tablet or capsule of the present invention can be coated with an enteric coating that dissolves at a pH of about 6.0 7 0
  • Suitable optional carriers include but are not limited to, for example, fatty acids, esters and salts thereof, that can be derived from any source, including, without limitation, natural or synthetic oils, fats, waxes or combinations thereof. Moreover, the fatty acids can be derived, without limitation, from non-hydrogenated oils, partially hydrogenated oils, fully hydrogenated oils or combinations thereof.
  • Non limiting exemplary sources of fatty acids include seed oil, fish or marine oil, canola oil, vegetable oil, safflower oil, sunflower oil, nasturtium seed oil, mustard seed oil, olive oil, sesame oil, soybean oil, corn oil, peanut oil, cottonseed oil, rice bran oil, babassu nut oil, palm oil, low erucic rapeseed oil, palm kernel oil, lupin oil, coconut oil, flaxseed oil, evening primrose oil, jojoba, wheat germ oil, tallow, beef tallow, butter, chicken fat, lard, dairy butterfat, shea butter or combinations thereof.
  • Specific non-limiting exemplary fish or marine oil sources include shellfish oil, tuna oil, mackerel oil, salmon oil, menhaden, anchovy, herring, trout, sardines or combinations thereof.
  • the source of the fatty acids is fish or marine oil (DHA or EPA), soybean oil or flaxseed oil.
  • beeswax can be used as a suitable carrier, as well as suspending agents such as silica (silicon dioxide).
  • the compositions of the invention can further include various ingredients to help stabilize, or help promote the bioavailability of the components of the beneficial compositions of the invention or serve as additional nutrients to an individual's diet. Suitable additives can include vitamins and biologically-acceptable minerals.
  • Non-limiting examples of vitamins include vitamin A, B vitamins, vitamin C, vitamin D, vitamin K and folic acid.
  • Non-limiting examples of minerals include iron, calcium, magnesium, potassium, copper, chromium, zinc, molybdenum, iodine, boron, selenium, manganese, derivatives thereof or combinations thereof. These vitamins and minerals can be from any source or combination of sources, without limitation.
  • Non-limiting exemplary B vitamins include, without limitation, thiamine, niacinamide, pyridoxine, riboflavin, cyanocobalamin, biotin, pantothenic acid or combinations thereof.
  • additives of the present composition include, without limitation, hyaluronic acid, starches, sugars, fats, antioxidants, amino acids, proteins, flavourings, colouring agents, hydrolysed starch(es) and derivatives thereof or combinations thereof.
  • compositions comprising the compositions of the invention can be manufactured by methods of conventional mixing, dissolving, granulating, dragee-making levigating, emulsifying, encapsulating, entrapping or lyophilization processes.
  • the compositions can be formulated in conventional manner using one or more physiologically acceptable carriers, diluents, excipients or auxiliaries that facilitate processing of the compositions into preparations that can be used.
  • antioxidant refers to synthetic or natural substances that prevent or delay the oxidative deterioration of a compound.
  • exemplary antioxidants include tocopherols, flavonoids, catechins, superoxide dismutase, lecithin, gamma oryzanol; vitamins, such as vitamins A, C (ascorbic acid) and beta-carotene; natural components such as camosol, camosic acid and rosmanol found in rosemary and hawthorn extract, proanthocyanidins such as those found in grapeseed or pine bark extract, and green tea extract.
  • compositions of the invention can take the form of, for example, lozenges, tablets or capsules prepared by conventional means with pharmaceutically acceptable excipients such as binding agents (e.g., pregelatinised maize starch, polyvinylpyrrolidone or hydroxypropyl methylcellulose); fillers (e.g., lactose, microcrystalline cellulose or calcium hydrogen phosphate); lubricants (e.g., magnesium stearate, talc or silica); disintegrants (e.g., potato starch or sodium starch glycolate); or wetting agents (e.g., sodium lauryl sulfate).
  • binding agents e.g., pregelatinised maize starch, polyvinylpyrrolidone or hydroxypropyl methylcellulose
  • fillers e.g., lactose, microcrystalline cellulose or calcium hydrogen phosphate
  • lubricants e.g., magnesium stearate, talc or silica
  • disintegrants e.
  • Preparations for oral administration can be suitably formulated to give controlled release of the composition as is well known.

Abstract

The present invention discloses a dietary supplement composition for an individual, comprising fish milt protein hydrolysate, fish skin protein hydrolysate, fish muscle protein hydrolysate, coenzyme Q10 and Vitis vinifera extract characterized in that combination of the fish milt protein hydrolysate, fish skin protein hydrolysate, fish muscle protein hydrolysate, coenzyme Q10 and Vitis vinifera extract having synergistic effect in increasing antioxidant defense for neutralising free radical.

Description

A DIETARY SUPPLEMENT COMPOSITION FOR ANTI-AGING
FIELD OF INVENTION The present invention generally relates to a dietary supplement composition for anti-aging. In particular, the present invention describes a dietary supplement composition for promoting anti-aging comprising marine organism-derived protein hydrolysates. BACKGROUND ART
Aging is a gradual, continuous process of natural change that begins in early adulthood. During early middle age, bodily functions begin to gradually decline. Many attempts have been undertaken to develop therapies and formulations that will lengthen human lifespans, enhance health, and increase quality of life as people age. As only few approaches completely comprehend the basis of ageing and illness, few, if any, of these attempts have yielded superior results to date. It's crucial to understand the causes of ageing and the illnesses that come with it, because as with treating a disease, one must first understand the problem, so that a precise remedy can be applied.
Referring to free radical theory of aging, aging is caused by accumulation of damage inflicted by reactive oxygen species that will eventually causes cell damage which cannot be repaired by internal mechanism, leading to loss of organ mass and functionality, which ultimately culminates in system dysfunction. Free radical damages contribute to many chronic health problems such as inflammatory diseases, cardiovascular diseases and directly influence the muscle functions and health. Severe chronic diseases are associated with aging such as cardiovascular disease (CVD), diabetic metabolic syndrome and Alzheimer’s disease. As the case of oxidative stress inflicted by free radical, the inflammatory response inadvertently disrupts cellular homeostasis. The oxidation and inflammatory theory of aging has been proposed, where aging is a loss of homeostasis due to the chronic oxidative stress that affects the regulatory and immune system. Accumulation of oxidative stress and inflammation will induce premature aging that may increase the risk of various diseases related to aging. Therefore, it is vital to address the prevention of these detrimental long-term outcomes as they are afflicting not only the aged but also the middle-age population.
Marine organism-derived protein hydrolysates may hold promise as functional foods to promote healthy ageing, metabolic health, and benefit skeletal muscle metabolism in humans. In accordance with this disclosure, a new approach to promoting health and longevity is to provide a dietary supplement composition which comprises fish- derived protein hydrolysates (FSH) that possesses antioxidant, anti-inflammatory and regenerative properties that will be able to prevent premature aging caused by free radical’s damage and inflammation, specifically on the skin, musculoskeletal and immune system.
SUMMARY OF INVENTION
An embodiment of the present invention provides a dietary supplement composition for an individual, comprising fish milt protein hydrolysate, fish skin protein hydrolysate, fish muscle protein hydrolysate, coenzyme Q10 and Vitis vinifera extract, characterized in that, combination of the fish milt protein hydrolysate, fish skin protein hydrolysate, fish muscle protein hydrolysate, coenzyme Q10 and Vitis vinifera extract having synergistic effect in increasing antioxidant defense for neutralising free radical.
Preferably, the composition comprises at least 100mg of fish milt protein hydrolysate.
Preferably, the composition comprises at least 100mg of fish skin protein hydrolysate.
Preferably, the composition comprises at least 30mg of fish muscle protein hydrolysate. Preferably, the composition comprises at least 10mg of coenzyme Q10.
Preferably, the composition comprises at least 10mg of Vitis vinifera extract.
Preferably, said dietary supplement composition further comprising one or more supplemental vitamins selected from the group consisting of vitamin A, vitamin C, vitamin E, vitamin K, thiamine, riboflavin, niacin, vitamin B6, folic acid, vitamin B12, biotin and panthothenic acid.
Preferably, said dietary supplement composition further comprising one or more supplemental vitamins selected from the group consisting of vitamin A, vitamin C, vitamin E, vitamin K, thiamine, riboflavin, niacin, vitamin B6, folic acid, vitamin B12, biotin and panthothenic acid. Preferably, said dietary supplement composition further comprising one or more supplemental minerals selected from the group consisting of iron, calcium, magnesium, potassium, copper, chromium, zinc, molybdenum, iodine, boron, selenium, manganese, or derivatives thereof.
The present invention may be embodied in other specific forms without departing from its essential characteristics. The described embodiments are to be considered in all respects only as illustrative and not restrictive. The scope of the invention is, therefore indicated by the appended claims rather than by the foregoing description. All changes, which come within the meaning and range of equivalency of the claims, are to be embraced within their scope.
DETAILED DESCRIPTION OF INVENTION
The present invention generally relates to a dietary supplement composition for anti-aging. In particular, the present invention describes a dietary supplement composition for promoting anti-aging comprising marine organism-derived protein hydrolysates.
Hereinafter, the dietary supplement composition according to the present invention will be described in detail according to the preferred embodiments. It is to be understood that limiting the description to the preferred embodiments of the invention is merely to facilitate discussion of the present invention and it is envisioned without departing from the scope of the appended claims.
The present invention discloses a dietary supplement composition for promoting anti-aging which comprises a combination of three main ingredients which are marine organism-derived protein hydrolysates. Three main components of the composition are derived from fish (fish-derived protein hydrolysates (FPH)) and commercially known as Protimune, Collactive, and Nutripeptin™, further fortified with Coenzyme Q10 (CoQ10) and extract of Vitis vinifera to provide synergy effect in neutralising free radicals at cellular level and reduce age related deteriorations in telomere maintenance, supporting normal metabolic functions, cell regulation and enhance DNA repair in both nuclei and mitochondria.
Protimune is milt protein hydrolysates which is made of fish milt with 26% DNA.lt is a DNA rich marine-organism extract that are known for its immunostimulant, antioxidant and anti-inflammatory properties.
Collactive is skin protein hydrolysates which is made of fish skin and contains 94% collagen and 6% elastin oligopeptide, the two main constituent of the extracellular matrix that provide tensile strength, regulation cell adhesion and direct tissue development. Nutripeptin™ is protein hydrolysates which is made of fish muscle protein and contains 80% protein and 888 total amino acids. Nutripeptin™ is a marine peptide that has a definite functional effect in reducing the glycaemic index, which results in lower postprandial blood glucose level, which further reduces the risk in developing disorders linked to unhealthy lifestyles such as diabetes and cardiovascular disease.
Fish protein hydrolysates (FPH) contains predominantly di- and tripeptides, which are more readily absorbed than free amino acids and and much more rapidly than intact protein. FPH also offers a high-quality supply of dietary protein without significantly affecting appetite perceptions or hormone regulation. The various FPH are breakdown products from the enzymatic conversion of fish proteins into smaller peptides, and normally contain 2-20 AAs. Coenzyme Q10 (CoQ10) (also known as ubiquinone and ubidecarenone) is a fat- soluble vitamin and naturally occurring coenzyme structurally similar to vitamin K. It is involved in electron transport and energy production in the mitochondria. Although found in all human cells, it is present in high concentrations in the heart, kidney, liver and pancreas. CoQ10 serves as a potent antioxidant with potential use as a dietary supplement to protect against related degeneration and has been reported to be capable of improving one’s performance by enhancing the uptake and processing of oxygen in cells. It is also effective for nourishing skin, curing heart disease, and promoting energy. Vitis Vinifera (grapes) extract confer health benefits as they have high antioxidant activities due to their phenolic and flavonoid contents. Resveratrol is also found in grape skin and has protection action on various disorders associated with aging.
In oxidative stress theory of aging, reactive oxygen and nitrogen species (RONS) are produced by several endogenous and exogenous processes and their negative effects are neutralized by antioxidant defenses. Oxidative stress occurs from the imbalance between RONS production and these antioxidant defenses. The oxidative stress theory of aging is based on the hypothesis that age- associated functional losses are due to the accumulation of RONS-induced damages.
The unique combination of fish milt protein hydrolysate, fish skin protein hydrolysate, fish muscle protein hydrolysate, ubiquinone and Vitis Vinifera acts as a free radical scavenger, DNA repair and cell regulation complex providing synergistic effects for optimal cellular function. Therefore, the dietary supplement composition provides a multifunctional and effective anti-aging management system.
The dietary supplement composition for anti-aging of the present invention contains the following:
Figure imgf000008_0001
Preferably, the preferred embodiment of the dietary supplement composition comprises at least 100 mg to 500 mg of Protimune (fish milt protein hydrolysates), 100mg to 500 mg of Collactive (fish skin protein hydrolysates), 30 mg to 500mg of Nutripeptin™ (fish muscle protein hydrolysates), 10mg to 100mg of Coenzyme Q10 and 10mg to 80mg of Vitis vinifera extract.
The effective dosage ranges from 200mg per day to 1600mg per day.
The preferred method of administration is oral to allow the formulation to be consumed in divided dosages with dosing interval, preferably 2 dosages per day. Preferably, the dietary supplement compositions are administered daily as dietary or nutritional supplements. The compositions can be taken with or without food. Formulation of the compositions of the invention into a soft gel capsule can be accomplished by many methods known in the art. Often the formulation will include an acceptable carrier, such as an oil, or other suspending or emulsifying agent.
The compositions of the invention can be formulated with suitable carriers such as starch, sucrose, or lactose in tablets, capsules, solutions, syrups and emulsions. The tablet or capsule of the present invention can be coated with an enteric coating that dissolves at a pH of about 6.0 7 0 A suitable enteric coating, which dissolves in the small intestine but not in the stomach, is cellulose acetate phthalate.
Suitable optional carriers include but are not limited to, for example, fatty acids, esters and salts thereof, that can be derived from any source, including, without limitation, natural or synthetic oils, fats, waxes or combinations thereof. Moreover, the fatty acids can be derived, without limitation, from non-hydrogenated oils, partially hydrogenated oils, fully hydrogenated oils or combinations thereof. Non limiting exemplary sources of fatty acids (their esters and salts) include seed oil, fish or marine oil, canola oil, vegetable oil, safflower oil, sunflower oil, nasturtium seed oil, mustard seed oil, olive oil, sesame oil, soybean oil, corn oil, peanut oil, cottonseed oil, rice bran oil, babassu nut oil, palm oil, low erucic rapeseed oil, palm kernel oil, lupin oil, coconut oil, flaxseed oil, evening primrose oil, jojoba, wheat germ oil, tallow, beef tallow, butter, chicken fat, lard, dairy butterfat, shea butter or combinations thereof.
Specific non-limiting exemplary fish or marine oil sources include shellfish oil, tuna oil, mackerel oil, salmon oil, menhaden, anchovy, herring, trout, sardines or combinations thereof. In particular, the source of the fatty acids is fish or marine oil (DHA or EPA), soybean oil or flaxseed oil. Alternatively or in combination with one of the above identified carrier, beeswax can be used as a suitable carrier, as well as suspending agents such as silica (silicon dioxide). The compositions of the invention can further include various ingredients to help stabilize, or help promote the bioavailability of the components of the beneficial compositions of the invention or serve as additional nutrients to an individual's diet. Suitable additives can include vitamins and biologically-acceptable minerals. Non-limiting examples of vitamins include vitamin A, B vitamins, vitamin C, vitamin D, vitamin K and folic acid. Non-limiting examples of minerals include iron, calcium, magnesium, potassium, copper, chromium, zinc, molybdenum, iodine, boron, selenium, manganese, derivatives thereof or combinations thereof. These vitamins and minerals can be from any source or combination of sources, without limitation. Non-limiting exemplary B vitamins include, without limitation, thiamine, niacinamide, pyridoxine, riboflavin, cyanocobalamin, biotin, pantothenic acid or combinations thereof.
Various additives can be incorporated into the present compositions. Optional additives of the present composition include, without limitation, hyaluronic acid, starches, sugars, fats, antioxidants, amino acids, proteins, flavourings, colouring agents, hydrolysed starch(es) and derivatives thereof or combinations thereof.
Compositions comprising the compositions of the invention can be manufactured by methods of conventional mixing, dissolving, granulating, dragee-making levigating, emulsifying, encapsulating, entrapping or lyophilization processes. The compositions can be formulated in conventional manner using one or more physiologically acceptable carriers, diluents, excipients or auxiliaries that facilitate processing of the compositions into preparations that can be used.
As used herein, the term “antioxidant” is recognized in the art and refers to synthetic or natural substances that prevent or delay the oxidative deterioration of a compound. Exemplary antioxidants include tocopherols, flavonoids, catechins, superoxide dismutase, lecithin, gamma oryzanol; vitamins, such as vitamins A, C (ascorbic acid) and beta-carotene; natural components such as camosol, camosic acid and rosmanol found in rosemary and hawthorn extract, proanthocyanidins such as those found in grapeseed or pine bark extract, and green tea extract. For oral administration, the compositions of the invention can take the form of, for example, lozenges, tablets or capsules prepared by conventional means with pharmaceutically acceptable excipients such as binding agents (e.g., pregelatinised maize starch, polyvinylpyrrolidone or hydroxypropyl methylcellulose); fillers (e.g., lactose, microcrystalline cellulose or calcium hydrogen phosphate); lubricants (e.g., magnesium stearate, talc or silica); disintegrants (e.g., potato starch or sodium starch glycolate); or wetting agents (e.g., sodium lauryl sulfate). The tablets can be coated by methods well known in the art with, for example, sugars, films or enteric coatings.
Preparations for oral administration can be suitably formulated to give controlled release of the composition as is well known.
Unless the context requires otherwise or specifically states to the contrary, integers, steps or elements of the invention recited herein as singular integers, steps, or elements clearly encompass both singular and plural forms of the recited integers, steps or elements.
Throughout this specification, unless the context requires otherwise, the word “comprise”, or variations such as “comprises” or “comprising”, will be understood to imply the inclusion of a stated step or element or integer or group of steps or elements or elements or integers, but not the exclusion of any other step or element or integer or group of steps, elements or integers. Thus, in the context of this specification, the term “comprising” is used in an inclusive sense and thus should be understood as meaning “including principally, but not necessarily solely”.

Claims

1. A dietary supplement composition for an individual, comprising: fish milt protein hydrolysate; fish skin protein hydrolysate; fish muscle protein hydrolysate; coenzyme Q10; and Vitis vinifera extract, characterized in that, combination of the fish milt protein hydrolysate, fish skin protein hydrolysate, fish muscle protein hydrolysate, coenzyme Q10 and Vitis vinifera extract having synergistic effect in increasing antioxidant defense for neutralising free radical.
2. The dietary supplement composition as claimed in claim 1, wherein the composition comprises at least 100mg of fish milt protein hydrolysate.
3. The dietary supplement composition as claimed in claim 1, wherein the composition comprises at least 100mg of fish skin protein hydrolysate.
4. The dietary supplement composition as claimed in claim 1, wherein the composition comprises at least 30mg of fish muscle protein hydrolysate.
5. The dietary supplement composition as claimed in claim 1, wherein the composition comprises at least 10mg of coenzyme Q10.
6. The dietary supplement composition as claimed in claim 1, wherein the composition comprises at least 10mg of Vitis vinifera extract.
7. The dietary supplement composition as claimed in claim 1, further comprising one or more supplemental vitamins selected from the group consisting of vitamin A, vitamin C, vitamin E, vitamin K, thiamine, riboflavin, niacin, vitamin B6, folic acid, vitamin B12, biotin and panthothenic acid.
8. The dietary supplement composition as claimed in claim 1, further comprising one or more supplemental minerals selected from the group consisting of iron, calcium, magnesium, potassium, copper, chromium, zinc, molybdenum, iodine, boron, selenium, manganese, or derivatives thereof.
PCT/IB2022/051526 2021-07-01 2022-02-22 A dietary supplement composition for anti-aging WO2023275626A1 (en)

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