ES2663392B2 - Nutritional supplement for the protection of neurons against the risk of Alzheimer's and Parkinson's in women combining isoflavones and docosahexaenoic acid. - Google Patents
Nutritional supplement for the protection of neurons against the risk of Alzheimer's and Parkinson's in women combining isoflavones and docosahexaenoic acid. Download PDFInfo
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- ES2663392B2 ES2663392B2 ES201600980A ES201600980A ES2663392B2 ES 2663392 B2 ES2663392 B2 ES 2663392B2 ES 201600980 A ES201600980 A ES 201600980A ES 201600980 A ES201600980 A ES 201600980A ES 2663392 B2 ES2663392 B2 ES 2663392B2
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
Abstract
Preparado nutricional eficaz en la protección de las neuronas frente al riesgo de Parkinson en mujeres que contiene una combinación de que isoflavonas y ácido docosahexaenoico, administrado a diferente dosis a lo largo del ciclo menstrual femenino.Nutritional preparation effective in protecting neurons against the risk of Parkinson's in women that contains a combination of isoflavones and docosahexaenoic acid, administered at different doses throughout the female menstrual cycle.
Description
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DESCRIPCIONDESCRIPTION
COMPLEMENTO NUTRICIONAL PARA LA PROTECCION DE LAS NEURONAS FRENTE AL RIESGO DE PARKINSON EN MUJERES COMBINANDO ISOFLAVONAS Y ACIDO DOCOSAHEXAENOICQ.NUTRITIONAL COMPLEMENT FOR THE PROTECTION OF NEURONS IN THE RISK OF PARKINSON IN WOMEN COMBINING ISOFLAVONES AND DOCOSAHEXAENOICQ ACID.
SECTOR DE LA TECNICATECHNICAL SECTOR
Se trata de un preparado nutricional que favorece la disminucion del riesgo de Parkinson especialmente indicado en la menopausiaIt is a nutritional preparation that favors the reduction of Parkinson's risk especially indicated in menopause
ANTECEDENTES DE LA INVENCIONBACKGROUND OF THE INVENTION
En los palses mas desarrollados la mujer pasa casi la mitad de su vida en menopausia. Elio aumenta considerablemente el riesgo de padecer Parkinson, al dejarse de producir las hormonas sexuales (estrogenos). Ademas, con la perdida de estrogenos disminuye la incorporation de acido docosahexaenoico al cerebro, por lo que aumenta aim mas el riesgo de Parkinson [Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinson's disease and incidental Parkinson's disease. Fabelo N, Martin V, Santpere G, Marin R, Torrent L, Ferrer I, Diaz M Mol Med 2011 Sep-Oct; 17(9-10): 1107-18], Actualmente no hay en el mercado neuro-nutraceuticos anti-Parkinson especificos para la menopausia.In more developed countries, women spend almost half of their lives in menopause. Elio greatly increases the risk of Parkinson's disease, by ceasing to produce sex hormones (estrogens). In addition, with the loss of estrogens, the incorporation of docosahexaenoic acid into the brain decreases, and therefore increases the risk of Parkinson's [Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinson's disease and incidental Parkinson's disease. Fabelo N, Martin V, Santpere G, Marin R, Torrent L, Ferrer I, Diaz M Mol Med 2011 Sep-Oct; 17 (9-10): 1107-18], There are currently no specific anti-Parkinson's neuro-nutraceutical products for menopause.
El uso de las isoflavonas para aliviar algunos efectos de la menopausia ya es conocido y esta en el mercado en diferentes formatos. Entre otros, la Guia Clinica de la Asociacion Espanola para el estudio de la Menopausia recoge el uso de isoflavonas como preparados a base de soja o de trebol rojo. Estos preparados se usan fundamentalmente para reducir la sintomatologia climaterica (sofocos, sindrome vasomotor, metabolismo oseo, atrofia vaginal). Tambien se utilizan a veces asociaciones de isoflavonas con otros compuestos como el lupulo, name, angelica china, aceite de onagra, raiz de ginseng, hiperico, valeriana, alfalfa, te verde y fitosteroles, para aliviar la action vasomotora, la absorcion de grasas y el metabolismo del colesterol, algunos efectos depresivos, y efectos antioxidantesThe use of isoflavones to relieve some effects of menopause is already known and is on the market in different formats. Among others, the Clinical Guide of the Spanish Association for the study of Menopause includes the use of isoflavones as preparations based on soybeans or red clover. These preparations are used primarily to reduce climacteric symptoms (hot flashes, vasomotor syndrome, bone metabolism, vaginal atrophy). Associations of isoflavones with other compounds such as hops, name, Chinese angelica, evening primrose oil, ginseng root, hypericum, valerian, alfalfa, green tea and phytosterols are also sometimes used to relieve vasomotor action, fat absorption and Cholesterol metabolism, some depressive effects, and antioxidant effects
Existen algunas empresas que ofrecen preparados actualmente disponibles en el mercado Algunos ejemplos son "Menodiet", 'Menofort", "Dysfem" y “Fitoladius" (preparados ricos en isoflavonas), “Medegin", “Ciclamar” (con vitaminas), y "Aquisoja" (con calcio y magnesio). Sin embargo, ninguno de estos preparados se utiliza para 5 mejorar sintomas relacionados con el deterioro cognitivo debido a la menopausia a nivel cerebral, que es lo que se reivindica en este documentoThere are some companies that offer preparations currently available in the market Some examples are "Menodiet", "Menofort", "Dysfem" and "Fitoladius" (preparations rich in isoflavones), "Medegin", "Cyclamar" (with vitamins), and " Aquisoja "(with calcium and magnesium). However, none of these preparations are used to improve symptoms related to cognitive impairment due to menopause at the brain level, which is what is claimed in this document
En relacion al acido docosahexaenoico, tambien conocido como omega-3 o DHA, se comercializa en diversas dosis, formatos y combinados por varias empresas, entre las 10 que figuran Uga nutraceuticals, Douglas labs, Pure, y las distribuidoras Nua y Oleum Dietetica. Estos preparados se utilizan para la salud del corazon, procesos antiinflamatorios, mejora de la agudeza visual, antiedad y los problemas del ciclo menstrual.In relation to docosahexaenoic acid, also known as omega-3 or DHA, it is marketed in various doses, formats and combined by several companies, among the 10 listed Uga nutraceuticals, Douglas labs, Pure, and distributors Nua and Oleum Dietetica. These preparations are used for heart health, anti-inflammatory processes, improvement of visual acuity, anti-aging and menstrual cycle problems.
15 Por otra parte, la empresa Nutricia puso en el mercado en el 2014 un preparado a base de una combinacion de nutrientes unica, que contiene varias vitaminas, omega 3, fosfolipidos y colina, y que se utiliza en pacientes en las primeras etapas de deterioro cognitivo leve como complemento alimentario.15 On the other hand, the company Nutricia put on the market in 2014 a preparation based on a combination of unique nutrients, which contains several vitamins, omega 3, phospholipids and choline, and which is used in patients in the early stages of deterioration Mild cognitive as a food supplement.
20 Sin embargo, no se conoce ningun producto que sea especifico para los efectos de la menopausia sobre los procesos cognitivos en mujeres que combine DHA con isoflavonas. Por una parte, se ha demostrado que la deficiencia de DHA en el cerebro es uno de los causantes del inicio de Parkinson, y que esta deficiencia se puede corregir parcialmente suministrando DHA en la dieta. Por otra parte, se sabe que los 25 niveles bajos de hormonas femeninas o estrogenos en sangre, como ocurre en la menopausia, tambien aumentan el riesgo de padecer estas enfermedades Ademas, nuestros datos recientes han demostrado que los estrogenos fomentan la incorporacion de DHA en el cerebro Sin embargo, hay que tener en consideracion que se desaconseja suministrar estrogenos a las mujeres porque pueden producir riesgos 30 para la salud en utero y colon, pero por el contrario se pueden utilizar isoflavonas (estrogenos de plantas) como sustitutivos, inocuos para la salud y con una actividad similar a los estrogenos humanos Con estas premisas, se propone como novedad elaborar un preparado que combine DHA e isoflavonas antes de que se inicie la menopausia, para que de esa manera se obtenga una situacion optima de 35 incorporacion de DHA en el cerebro para su funcionamiento normal, reduciendo los riesgos de sufrir degeneracion cerebral20 However, there is no known product that is specific for the effects of menopause on cognitive processes in women that combine DHA with isoflavones. On the one hand, it has been shown that DHA deficiency in the brain is one of the causes of the onset of Parkinson's, and that this deficiency can be partially corrected by providing DHA in the diet. On the other hand, it is known that the 25 low levels of female hormones or estrogens in the blood, as in menopause, also increase the risk of suffering from these diseases. In addition, our recent data has shown that estrogens promote the incorporation of DHA into the brain However, it should be taken into account that it is not advisable to supply estrogens to women because they can produce health risks in the uterus and colon, but on the contrary, isoflavones (plant estrogens) can be used as substitutes, harmless to health and with an activity similar to human estrogens With these premises, it is proposed as a novelty to prepare a preparation that combines DHA and isoflavones before the menopause begins, so that in this way an optimal situation of incorporating DHA into the brain for normal functioning, reducing the risk of brain degeneration
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Solo se conocen dos referencias: [Effects of oestradiol on brain lipid class and Fatty Acid composition: comparison between pregnant and ovariectomised oestradiol-treated rats. Fabelo N Martin V, Gonzalez C, Alonso A, Diaz M J Neuroendocnnol. 2012 Feb;24(2):292-309], [Oestrogens as modulators of neuronal signalosomes and brain lipid homeostasis related to protection against neurodegeneration. Marin R, Casanas V, Perez JA, Fabelo N, Fernandez CE, Diaz M J Neuroendocrinol. 2013 Nov;25(11)1104-15.)]; y ninguna de ellas ofrece una combinacion de DHA con isoflavonas, ni se extrapola a efectos menopausicos.Only two references are known: [Effects of oestradiol on brain lipid class and Fatty Acid composition: comparison between pregnant and ovariectomised oestradiol-treated rats. Fabelo N Martin V, Gonzalez C, Alonso A, Diaz M J Neuroendocnnol. 2012 Feb; 24 (2): 292-309], [Oestrogens as modulators of neuronal signalosomes and brain lipid homeostasis related to protection against neurodegeneration. Marin R, Casanas V, Perez JA, Fabelo N, Fernandez CE, Diaz M J Neuroendocrinol. 2013 Nov; 25 (11) 1104-15.)]; and none of them offers a combination of DHA with isoflavones, nor is it extrapolated to menopausal effects.
En relacion al DHA y sus efectos beneficiosos, existen diversas publicaciones cientificas que indican que es un acido graso esencial en el funcionamiento cerebral Ademas, los humanos no lo producimos de manera eficaz, por lo que debe ser incorporado en la dieta Si bien aun los estudios clinicos son escasos, algunos ensayos efectuados en distintos modelos experimentales demostraron que habia mejorias en las disquinesias tipicas de esta enfermedad [Dyall, Simon C. Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA Front Aging Neurosci. 2015; 7 52. Doi:In relation to DHA and its beneficial effects, there are several scientific publications that indicate that it is an essential fatty acid in brain functioning. In addition, humans do not produce it effectively, so it must be incorporated into the diet, although even studies There are few clinical trials, some trials in different experimental models showed that there were improvements in the typical dyskinesias of this disease [Dyall, Simon C. Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA , DPA and DHA Front Aging Neurosci. 2015; 7 52. Doi:
10.3389/fnagi.2015.00052], Por otra parte, otros estudios efectuados en pacientes con deterioro cognitivo a los que se trato con DHA en diversos formatos (ingesta de pescado regular, dosis elevadas diarias de DHA en extracto, etc) demostraron que habia mejorias en el deterioro cognitivo en estos pacientes. [Diaz M y Marin R. Brain polyunsaturated lipids and neurodegenerative diseases, en Nutraceuticals and Functional foods: natural remedy Nova Publishers, 2014. ISBN: 978-1-62948-783-0 ]10.3389 / fnagi.2015.00052], On the other hand, other studies carried out in patients with cognitive impairment who were treated with DHA in various formats (regular fish intake, high daily doses of DHA in extract, etc.) showed that there were improvements in cognitive impairment in these patients. [Diaz M and Marin R. Brain polyunsaturated lipids and neurodegenerative diseases, in Nutraceuticals and Functional foods: natural remedy Nova Publishers, 2014. ISBN: 978-1-62948-783-0]
EXPLICACION DE LA INVENCIONEXPLANATION OF THE INVENTION
Se propone una solucion de neuro-nutraceuticos especificos para mujeres antes de alcanzar la menopausia que contengan fitoestrogenos (isoflavonas) para sustituir a los estrogenos paulatinamente, y acido docosahexaenoico (DHA) para el funcionamiento cerebral. Para ser eficaces en la proteccion de las neuronas frente al riesgo de Parkinson, ambos productos son esenciales y deben tomarse combinados, respetando las dosis a lo largo del ciclo menstrual femenino.A specific neuro-nutraceutical solution for women is proposed before reaching menopause containing phytoestrogens (isoflavones) to replace estrogens gradually, and docosahexaenoic acid (DHA) for brain function. To be effective in protecting neurons against Parkinson's risk, both products are essential and must be taken in combination, respecting the doses throughout the female menstrual cycle.
Los nutraceuticos (de la union de “nutricion’1 y “farmaceutico”) son sustancias naturales que encontramos en los alimentos y que contribuyen a favorecer o mejorar nuestra salud, incluida la salud cerebralNutraceuticals (from the union of "nutrition" and "pharmaceutical") are natural substances that we find in food and that contribute to favoring or improving our health, including brain health
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En concreto, el complemento nutricional con DHA y fitoestrogenos (isoflavonas) como preventivo de Parkinson esta indicado para la etapa inmediatamente anterior a la menopausia (pre-menopausia, entre los 45 y 50 anos de edad). Adicionalmente, conviene senalar que se trata de reproducir el ciclo menstrual de la mujer, en la que las dosis de la hormona varian a lo largo del ciclo menstrualSpecifically, the nutritional supplement with DHA and phytoestrogens (isoflavones) as a preventive for Parkinson's is indicated for the stage immediately before menopause (pre-menopause, between 45 and 50 years of age). Additionally, it should be noted that it is about reproducing the woman's menstrual cycle, in which the doses of the hormone vary throughout the menstrual cycle
REALIZACION PREFERENTE DE LA INVENCIONPREFERRED EMBODIMENT OF THE INVENTION
Para el paliativo contra Parkinson se elabora un preparado de aceite de pescado o de aceite de linaza con una proporcion 200-300 mg/dia de DHA, en la siguiente combinacion:For the palliative against Parkinson's, a fish oil or flaxseed oil preparation is prepared with a proportion of 200-300 mg / day of DHA, in the following combination:
-Entre los dias 7 al 23 del ciclo 25-35 g de proteina de soja, o 50-60 mg de isoflavonas (equivalente a 98% de proteina de soja)- Between days 7 to 23 of the cycle 25-35 g of soy protein, or 50-60 mg of isoflavones (equivalent to 98% of soy protein)
-Entre los dias 1-7 y del 23-30 del ciclo menstrual: 2-3 g de proteina de soja, o 4,0-5,0 mg de isoflavonas (equivalente al 13% de proteina de soja).- Between days 1-7 and 23-30 of the menstrual cycle: 2-3 g of soy protein, or 4.0-5.0 mg of isoflavones (equivalent to 13% of soy protein).
Este preparado deberia conseguir aumentar la cantidad de DHA que se incorpora al cerebro lo cual seria altamente beneficioso para prevenir estas enfermedades.This preparation should increase the amount of DHA that is incorporated into the brain which would be highly beneficial to prevent these diseases.
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| Application Number | Priority Date | Filing Date | Title |
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| ES201600980A ES2663392B2 (en) | 2016-05-17 | 2016-05-17 | Nutritional supplement for the protection of neurons against the risk of Alzheimer's and Parkinson's in women combining isoflavones and docosahexaenoic acid. |
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| Application Number | Priority Date | Filing Date | Title |
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| ES201600980A ES2663392B2 (en) | 2016-05-17 | 2016-05-17 | Nutritional supplement for the protection of neurons against the risk of Alzheimer's and Parkinson's in women combining isoflavones and docosahexaenoic acid. |
Publications (3)
| Publication Number | Publication Date |
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| ES2663392A2 ES2663392A2 (en) | 2018-04-12 |
| ES2663392R1 ES2663392R1 (en) | 2018-05-10 |
| ES2663392B2 true ES2663392B2 (en) | 2018-09-24 |
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| ES201600980A Active ES2663392B2 (en) | 2016-05-17 | 2016-05-17 | Nutritional supplement for the protection of neurons against the risk of Alzheimer's and Parkinson's in women combining isoflavones and docosahexaenoic acid. |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH06237734A (en) * | 1991-11-06 | 1994-08-30 | Sanwa Kagaku Kenkyusho Co Ltd | Food composition for hypofunctional disease |
| IL158552A0 (en) * | 2003-10-22 | 2004-05-12 | Enzymotec Ltd | Lipids containing omega-3 fatty acids |
| JP2006325457A (en) * | 2005-05-25 | 2006-12-07 | Daicho Kikaku:Kk | Health food |
| US20140314911A1 (en) * | 2013-04-18 | 2014-10-23 | Shandong Shenghai Health Care Products Co., Ltd. | Deep-Sea Fish Oil Capsule and its Preparation Method |
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| ES2663392R1 (en) | 2018-05-10 |
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