WO2023245992A1 - 一种肿瘤细胞辅助诊断试剂盒 - Google Patents

一种肿瘤细胞辅助诊断试剂盒 Download PDF

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Publication number
WO2023245992A1
WO2023245992A1 PCT/CN2022/135780 CN2022135780W WO2023245992A1 WO 2023245992 A1 WO2023245992 A1 WO 2023245992A1 CN 2022135780 W CN2022135780 W CN 2022135780W WO 2023245992 A1 WO2023245992 A1 WO 2023245992A1
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magnetic
tumor cell
auxiliary diagnosis
diagnosis kit
cell auxiliary
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PCT/CN2022/135780
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English (en)
French (fr)
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戴俊程
解艳芳
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南京亿科人群健康研究院有限公司
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Publication of WO2023245992A1 publication Critical patent/WO2023245992A1/zh

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/02—Internal fittings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/02—Internal fittings
    • B65D25/10—Devices to locate articles in containers
    • B65D25/108—Devices, e.g. plates, presenting apertures through which the articles project
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/20—External fittings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D39/00—Closures arranged within necks or pouring openings or in discharge apertures, e.g. stoppers
    • B65D39/08—Threaded or like closure members secured by rotation; Bushes therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D43/00—Lids or covers for rigid or semi-rigid containers
    • B65D43/14—Non-removable lids or covers
    • B65D43/16—Non-removable lids or covers hinged for upward or downward movement
    • B65D43/163—Non-removable lids or covers hinged for upward or downward movement the container and the lid being made separately
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/24—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
    • B65D51/245—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes provided with decoration, information or contents indicating devices, labels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D53/00—Sealing or packing elements; Sealings formed by liquid or plastics material
    • B65D53/02—Collars or rings
    • G—PHYSICS
    • G08—SIGNALLING
    • G08B—SIGNALLING OR CALLING SYSTEMS; ORDER TELEGRAPHS; ALARM SYSTEMS
    • G08B5/00—Visible signalling systems, e.g. personal calling systems, remote indication of seats occupied

Definitions

  • the present invention relates to the technical field of kits, and more specifically, to a tumor cell auxiliary diagnosis kit.
  • the test kit is a box used to contain chemical reagents for testing chemical components, drug residues, virus types, etc. Generally used by hospitals and pharmaceutical companies.
  • Tumor cells are essentially tumors.
  • Tumor tissue is composed of parenchyma and stroma.
  • Tumor parenchyma is tumor cells, the main component of tumors, and has tissue origin specificity. It determines the biology of the tumor and the specificities of each tumor.
  • the tissue origin of various tumors is usually identified based on the parenchymal morphology of the tumor, the classification, naming and histological diagnosis of tumors are performed, and the benign and malignant tumors and the malignant degree of the tumor are determined based on their differentiation, maturity and size of atypia.
  • Tumor cells have three significant basic characteristics: immortality, migration and loss of contact inhibition. In addition, tumor cells have many physiological, biochemical and morphological characteristics that are different from normal cells.
  • the purpose of the present invention is to provide a tumor cell auxiliary diagnosis kit, which can adopt a special sealing method and rely on the thread seal between the sealing plug and the test tube to achieve convenient access to the reagents.
  • the sensing self-heating capsule in the sealing plug is used to sense the sealing.
  • the sensing self-heating capsule in the sealing plug can sense the oxygen in the air in time. And react with it to generate heat, which in turn prompts the self-heating capsule to partially melt, and then expands downward under the action of magnetic attraction. It relies on visual changes to provide sealing warnings to technicians, which can effectively prevent contaminated reagents from being Misuse, improve the reliability and safety of reagent diagnosis.
  • the present invention adopts the following technical solutions.
  • a tumor cell auxiliary diagnosis kit including a box body.
  • a matching box cover is rotatably connected to the upper side of the box body.
  • a matching sealing strip is bonded between the box body and the box cover.
  • the inner side of the box body is A fixed plate is provided, and a plurality of evenly distributed elastic telescopic rods are fixedly connected between the fixed plate and the bottom of the box body.
  • a plurality of evenly distributed sealing plugs are fixedly connected to the lower end of the fixed plate, and the lower end of the sealing plug is threadedly connected.
  • a sensing groove is provided at the lower end of the sealing plug.
  • a self-heating sensing device is installed in the sensing groove. bag.
  • the box body includes an outer box, a sponge pad and a magnetic layer.
  • the magnetic layer is fixedly connected to the inner bottom of the outer box.
  • the sponge pad is fixedly connected to the upper end of the magnetic layer.
  • the upper end of the sponge pad has an opening. There are multiple soft positioning grooves that match the test tubes.
  • the sponge pad protects the test tubes.
  • the magnetic layer can actively apply magnetic suction to intervene after sensing the seal failure of the self-heating bag to improve the perception of the self-heating bag. The degree of expansion can promote the early warning effect.
  • the elastic telescopic rod is in a compressed state, and the extended height of the elastic telescopic rod is higher than the height of the box body. After the box cover is opened, the fixed plate can be actively lifted up by the elastic telescopic rod, thereby facilitating the removal of the test tube for diagnosis. use.
  • the sensing self-heating bag includes an outer breathable film, a porous thermally conductive partition and a plurality of thermally softened magnetic balls.
  • the outer breathable film is fixedly connected to the notch of the sensing groove, and the porous thermally conductive partition is fixedly connected to Inside the sensing tank, the heat-softening magnetic balls are evenly arranged on the side of the porous thermally conductive partition away from the outer breathable film.
  • An elastic drawstring is fixedly connected between the heat-softening magnetic balls and the top wall of the sensing tank. After a sealing failure occurs, , outside air enters the test tube, and then enters the inside through the outer breathable film, and reacts with the self-heating material to generate heat.
  • the heat is conducted to the heat-softening magnetic ball through the porous heat-conducting partition, thereby causing it to soften, and then in the magnetic attraction It passes through the porous heat-conducting partition under the magnetic force of the layer, and pushes up the outer breathable film to warn of downward expansion.
  • the outer breathable film is an elastic waterproof breathable film, and a self-heating material is filled between the outer breathable film and the porous thermally conductive partition.
  • the height of the diagnostic reagent is lower than the maximum deformation length of the outer breathable membrane, and the remaining space in the test tube is filled with nitrogen. On the one hand, the diagnostic reagent is protected, and on the other hand, it is less likely to cause false interference to the sensing self-heating capsule.
  • the heat-softening magnetic ball includes a deformable outer garment, a hot-melt interlayer and a magnetic core.
  • the magnetic inner core is arranged inside the deformable outer garment.
  • the hot-melt interlayer is filled between the deformable outer garment and the magnetic inner core.
  • the interlayer supports the overall shape of the heat-softened magnetic ball, so that it is not easy to pass through the porous thermally conductive partition. After the sealing failure occurs, air enters, and then reacts to generate heat to cause the hot-melt interlayer to melt, and then the magnetic core is in The magnetic layer moves downward through the porous thermally conductive partition under the action of magnetic attraction, forcing the porous thermally conductive partition to expand downward.
  • the deformable outer garment is made of elastic thermally conductive material
  • the hot-melt interlayer is made of hot-melt material with a low melting point, and the melting point is higher than room temperature.
  • the mesh diameter of the porous thermally conductive partition is smaller than the diameter of the heat-softening magnetic ball and larger than the diameter of the hot-melt interlayer.
  • the outside of the deformable coat is coated with a color paint layer, and the deformation coat with the color paint layer is pushed outside. After the breathable membrane expands, the visual warning effect for technicians is better.
  • test tube and the outer breathable film are both made of transparent material, and the front end of the lid is inlaid with a corresponding viewing window.
  • This solution can adopt a special sealing method, relying on the thread seal between the sealing plug and the test tube to achieve convenient access to reagents.
  • the sensing self-heating bag in the sealing plug can be used to sense the sealing.
  • the sensing self-heating capsule in the sealing plug can sense the oxygen in the air in time and react with it to generate heat, which in turn causes the sensing self-heating capsule to partially melt.
  • the downward expansion action occurs under the action of magnetic suction, and the visual changes are used to provide sealing warnings to technicians, which can effectively prevent the misuse of contaminated reagents and improve the credibility and safety of reagent diagnosis.
  • the box body includes an outer box, a sponge pad and a magnetic layer.
  • the magnetic layer is fixedly connected to the inner bottom of the outer box.
  • the sponge pad is fixedly connected to the upper end of the magnetic layer.
  • the matching soft positioning groove and sponge pad protect the test tube.
  • the magnetic layer can actively apply magnetic suction to intervene after sensing the seal failure of the self-heating bag to increase the degree of expansion of the self-heating bag. Promote early warning effects.
  • the sensing self-heating bag includes an outer breathable film, a porous thermally conductive partition and multiple thermally softened magnetic balls.
  • the outer breathable film is fixedly connected to the notch of the sensing slot, and the porous thermally conductive partition is fixedly connected to the inside of the sensing slot.
  • the heat-softening magnetic balls are evenly arranged on the side of the porous heat-conducting partition away from the outer breathable film.
  • the heat is conducted to the thermally softened magnetic ball through the porous thermally conductive partition, thereby causing it to soften, and then under the magnetic attraction force of the magnetic attraction layer Pass through the porous heat-conducting partition and push up the outer breathable film to warn of expansion downward.
  • the height of the diagnostic reagent in this solution is lower than the maximum deformation length of the outer breathable membrane, and the remaining space in the test tube is filled with nitrogen. On the one hand, it protects the diagnostic reagent, and on the other hand, it is less likely to cause false interference to the sensing self-heating capsule.
  • the heat-softened magnetic ball includes a deformable coat, a hot-melt interlayer and a magnetic core.
  • the magnetic core is set inside the deformable coat, and the hot-melt interlayer is filled between the deformable coat and the magnetic core.
  • the hot-melt interlayer is in a normal state.
  • the bottom supports the overall shape of the heat-softened magnetic ball, so that it is not easy to pass through the porous thermally conductive partition. After the sealing failure occurs, air enters, and then reacts to generate heat to melt the hot-melt interlayer, and then the magnetic core is in the magnetic attraction layer. It moves downward through the porous heat-conducting partition under the action of magnetic attraction, forcing the porous heat-conducting partition to expand downward to warn the lower side.
  • the mesh diameter of the porous thermally conductive partition is smaller than the diameter of the heat-softening magnetic ball and larger than the diameter of the hot-melt interlayer.
  • the outside of the deformable coat is coated with a color paint layer.
  • the deformable coat with the color paint layer is breathable when pushed. After the membrane expands, the visual warning effect for technicians is better.
  • Figure 1 is a schematic structural diagram of the present invention
  • Figure 2 is a cross-sectional view of the present invention
  • Figure 3 is a schematic structural diagram of the test tube part of the present invention in a normal state
  • Figure 4 is a schematic structural diagram of the sealing plug of the present invention.
  • Figure 5 is a schematic structural diagram of the thermally softened magnetic ball of the present invention.
  • Figure 6 is a schematic structural diagram of the test tube in the state of partial air leakage according to the present invention.
  • connection can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediary, or it can be inside two components of connectivity.
  • Connection can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediary, or it can be inside two components of connectivity.
  • a tumor cell auxiliary diagnosis kit includes a box body 1.
  • a matching box cover 2 is rotatably connected to the upper side of the box body 1.
  • a matching box body 1 and the box cover 2 are bonded to each other.
  • the sealing strip 3 is provided with a fixed plate 5 on the inside of the box body 1.
  • the lower end of the fixed plate 5 is fixedly connected with a plurality of evenly distributed elastic telescopic rods 6.
  • Sealing plug 7, the lower end of sealing plug 7 is threadedly connected with a matching test tube 8, and the test tube 8 contains diagnostic reagents for tumor cells.
  • the diagnostic reagent is an existing product, and the specific ingredients will not be repeated here.
  • Sealing plug 7 and test tube 8 There are 10 wrapped between them, a sensing groove is provided at the lower end of the sealing plug 7, and a sensing self-heating bag 9 is installed in the sensing groove.
  • test tube 8 and the outer breathable membrane 91 are both made of transparent material, and the front end of the box lid 2 is embedded and connected with a corresponding viewing window 4 .
  • the box body 1 includes an outer box 11, a sponge pad 12 and a magnetic layer 13.
  • the magnetic layer 13 is fixedly connected to the inner bottom of the outer box 11.
  • the sponge pad 12 is fixedly connected to the upper end of the magnetic layer 13.
  • the sponge pad The upper end of 12 is provided with a plurality of soft positioning grooves that match the test tube 8.
  • the sponge pad 12 protects the test tube 8.
  • the magnetic attraction layer 13 can actively apply magnetic attraction after sensing the sealing failure of the self-heating bag 9. Intervention is performed to increase the degree of expansion of the self-heating bladder 9 to promote the early warning effect.
  • the elastic telescopic rod 6 is in a compressed state, and the extended height of the elastic telescopic rod 6 is higher than the height of the box body 1. After opening the box cover 2, the fixed plate 5 can be actively lifted up by the elastic telescopic rod 6, so as to facilitate the removal of the test tube 8. For diagnostic use.
  • the sensing self-heating bag 9 includes an outer breathable film 91, a porous thermally conductive partition 92 and a plurality of thermally softened magnetic balls 93.
  • the outer breathable film 91 is fixedly connected to the notch of the sensing groove, and the porous thermally conductive partition 92 is fixed.
  • the heat-softening magnetic balls 93 are evenly arranged on the side of the porous thermally conductive partition 92 away from the outer breathable film 91.
  • An elastic drawstring is fixedly connected between the heat-softening magnetic balls 93 and the top wall of the sensing groove.
  • the outside air enters the test tube 8, and then enters the inside through the outer breathable film 91, and reacts with the self-heating material to generate heat.
  • the heat is conducted to the heat-softening magnetic ball 93 through the porous heat-conducting partition 92, thereby causing it to It softens, and then passes through the porous thermally conductive partition 92 under the magnetic attraction force of the magnetic attraction layer 13, pushing up the outer breathable film 91 to give a warning of downward expansion.
  • the outer breathable film 91 is an elastic waterproof breathable film, and a self-heating material is filled between the outer breathable film 91 and the porous thermally conductive partition 92 .
  • the height of the diagnostic reagent is lower than the maximum deformation length of the outer breathable membrane 91, and the remaining space in the test tube 8 is filled with nitrogen. On the one hand, the diagnostic reagent is protected, and on the other hand, it is less likely to cause false interference to the sensing self-heating bag 9.
  • the heat-softening magnetic ball 93 includes a deformable outer garment 931, a hot-melt interlayer 932 and a magnetic core 933.
  • the magnetic inner core 933 is arranged inside the deformable outer garment 931, and the hot-melt interlayer 932 is filled in the deformable outer garment 931 and the magnetic inner core 933.
  • the hot-melt interlayer 932 supports the overall shape of the thermally softened magnetic ball 93, so that it is not easy to pass through the porous thermally conductive partition 92.
  • the interlayer 932 melts, and then the magnetic core 933 moves downward through the porous thermally conductive partition 92 under the magnetic attraction of the magnetic layer 13, forcing the porous thermally conductive partition 92 to expand downward.
  • the deformable coat 931 is made of elastic thermally conductive material
  • the hot-melt interlayer 932 is made of hot-melt material with a low melting point, and the melting point is higher than room temperature.
  • the mesh diameter of the porous heat-conducting partition 92 is smaller than the diameter of the heat-softening magnetic ball 93 and larger than the diameter of the hot-melt interlayer 932.
  • the outside of the deformable coat 931 is coated with a color paint layer. The deformable coat 931 with the color paint layer pushes the outer breathable film After the expansion of 91 occurs, the visual warning effect for technicians is better.
  • the present invention can adopt a special sealing method, relying on the thread seal between the sealing plug 7 and the test tube 8 to achieve convenient access to reagents, and at the same time, the sensing self-heating bag 9 in the sealing plug 7 is used to improve the sealing performance.
  • the sensing self-heating bag 9 in the sealing plug 7 can sense the oxygen in the air in time and react with it to generate heat, thereby promoting It senses that the self-heating bag 9 is partially melted, and then expands downward under the action of magnetic attraction. It relies on visual changes to provide sealing warnings to technicians, which can effectively prevent contaminated reagents from being misused and improve the credibility of reagent diagnosis. degree and safety.

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  • Mechanical Engineering (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

一种肿瘤细胞辅助诊断试剂盒，该试剂盒通过密封塞（7）和试管（8）之间的螺纹密封来实现试剂的方便取用，同时利用密封塞（7）内的感知自热囊（9）对密封性进行感知，当密封性失效时，外界的空气首先进入试管（8）内，密封塞（7）内的感知自热囊（9）可以及时感知到空气中的氧气并与其发生反应来产生热量，促使感知自热囊（9）部分熔化，进而在磁吸作用下发生向下膨胀动作，以通过视觉上的变化来对技术人员进行密封失效预警，避免了受到污染的试剂被误用，提高了试剂诊断的可信度以及安全性。

Description

一种肿瘤细胞辅助诊断试剂盒 技术领域
本发明涉及试剂盒技术领域，更具体地说，涉及一种肿瘤细胞辅助诊断试剂盒。
背景技术
试剂盒是用于盛放检测化学成分、药物残留、病毒种类等化学试剂的盒子。一般医院、制药企业使用。
肿瘤细胞实质就是肿瘤。肿瘤组织由实质和间质两部分构成，肿瘤实质是肿瘤细胞，是肿瘤的主要成分，具有组织来源特异性。它决定肿瘤的生物学特点以及每种肿瘤的特殊性。通常根据肿瘤的实质形态来识别各种肿瘤的组织来源，进行肿瘤的分类、命名和组织学诊断，并根据其分化成熟程度和异型性大小来确定肿瘤的良恶性和肿瘤的恶性程度。肿瘤细胞有三个显著的基本特征即：不死性，迁移性和失去接触抑制。除此之外，肿瘤细胞还有许多不同于正常细胞的生理、生化和形态特征。
现有技术中存在对肿瘤细胞进行诊断的试剂盒，但是对存放要求较为严格，导致使用起来极为不便，同时难以在长时间的运输或者保存过程中，始终保证良好的密封隔离性，一旦出现外界空气或者杂质进入污染的情况，容易导致试剂无法正常使用。
发明内容
1.要解决的技术问题
针对现有技术中存在的问题，本发明的目的在于提供一种肿瘤细胞辅助诊断试剂盒，可以实现采用特殊的密封方式，依靠密封塞和试管之间的螺纹密封来实现试剂的方便取用，同时利用密封塞内的感知自热囊对密封性进行感知，当出现密封性失效的时候，外界的空气首先进入到试管内，密封塞内 的感知自热囊可以及时的感知到空气中的氧气并与其发生反应来产生热量，进而促使感知自热囊部分熔化，进而在磁吸作用下发生向下膨胀动作，依靠视觉上的变化来对技术人员进行密封预警，可以有效避免受到污染的试剂被误用，提高试剂诊断的可信度以及安全性。
2.技术方案
为解决上述问题，本发明采用如下的技术方案。
一种肿瘤细胞辅助诊断试剂盒，包括盒身，所述盒身上侧转动连接有相匹配的盒盖，所述盒身和盒盖之间粘接有相匹配的包封条，所述盒身内侧设有固定板，所述固定板与盒身底部之间固定连接有多根均匀分布的弹性伸缩杆，所述固定板下端固定连接有多个均匀分布的密封塞，所述密封塞下端螺纹连接有相匹配的试管，所述试管内盛放有肿瘤细胞的诊断试剂，所述密封塞和试管之间包裹有，所述密封塞下端开设有感知槽，所述感知槽内安装有感知自热囊。
进一步的，所述盒身包括外盒、海绵垫以及磁吸层，所述磁吸层固定连接于外盒内底端，所述海绵垫固定连接于磁吸层上端，所述海绵垫上端开设有多个与试管相匹配的软定位槽，海绵垫起到对试管的保护作用，磁吸层则可以在感知自热囊感知到密封失效后，主动施加磁吸力进行干预，提高感知自热囊的膨胀的程度来促进预警效果。
进一步的，所述弹性伸缩杆处于压缩状态，且弹性伸缩杆延伸后的高度高于盒身的高度，可以在打开盒盖后通过弹性伸缩杆主动顶起固定板，进而方便取下试管进行诊断使用。
进一步的，所述感知自热囊包括外透气膜、多孔导热隔板以及多个热软化磁球，所述外透气膜固定连接于感知槽的槽口处，所述多孔导热隔板固定连接于感知槽内部，所述热软化磁球均匀设置于多孔导热隔板远离外透气膜的一侧，所述热软化磁球与感知槽顶壁之间固定连接有弹性拉绳，在发生密 封失效后，外界空气进入到试管内，然后通过外透气膜进入到内侧，并与自发热材料进行反应产生热量，热量通过多孔导热隔板传导至热软化磁球上，从而促使其软化，进而在磁吸层的磁吸作用力下穿过多孔导热隔板，顶起外透气膜向下侧膨胀预警。
进一步的，所述外透气膜为弹性的防水透气膜，所述外透气膜和多孔导热隔板之间填充有自发热材料。
进一步的，所述诊断试剂的高度低于外透气膜的最大形变长度，所述试管内其余空间填充有氮气，一方面对诊断试剂进行保护，另一方面不易对感知自热囊造成误干扰。
进一步的，所述热软化磁球包括形变外衣、热熔夹层以及磁性内芯，所述磁性内芯设置于形变外衣内部，所述热熔夹层填充于形变外衣和磁性内芯之间，热熔夹层正常状态下对热软化磁球的整体形状进行支撑，从而不易从多孔导热隔板中穿过，在发生密封失效后空气进入，进而发生反应产生热量促使热熔夹层熔化，进而磁性内芯在磁吸层的磁吸作用下穿过多孔导热隔板向下移动，迫使多孔导热隔板向下侧膨胀预警。
进一步的，所述形变外衣采用弹性导热材料制成，所述热熔夹层采用低熔点的热熔性材料制成，且熔点高于室温。
进一步的，所述多孔导热隔板的网孔直径小于热软化磁球的直径并大于热熔夹层的直径，所述形变外衣外侧涂覆有彩漆层，具有彩漆层的形变外衣在推动外透气膜发生膨胀后，对技术人员的可视化预警效果更好。
进一步的，所述试管和外透气膜均为透明材质，所述盒盖前端镶嵌连接有相对应的可视窗。
3.有益效果
相比于现有技术，本发明的优点在于：
(1)本方案可以实现采用特殊的密封方式，依靠密封塞和试管之间的螺纹密封来实现试剂的方便取用，同时利用密封塞内的感知自热囊对密封性进行感知，当出现密封性失效的时候，外界的空气首先进入到试管内，密封塞内的感知自热囊可以及时的感知到空气中的氧气并与其发生反应来产生热量，进而促使感知自热囊部分熔化，进而在磁吸作用下发生向下膨胀动作，依靠视觉上的变化来对技术人员进行密封预警，可以有效避免受到污染的试剂被误用，提高试剂诊断的可信度以及安全性。
(2)本方案中盒身包括外盒、海绵垫以及磁吸层，磁吸层固定连接于外盒内底端，海绵垫固定连接于磁吸层上端，海绵垫上端开设有多个与试管相匹配的软定位槽，海绵垫起到对试管的保护作用，磁吸层则可以在感知自热囊感知到密封失效后，主动施加磁吸力进行干预，提高感知自热囊的膨胀的程度来促进预警效果。
(3)本方案中感知自热囊包括外透气膜、多孔导热隔板以及多个热软化磁球，外透气膜固定连接于感知槽的槽口处，多孔导热隔板固定连接于感知槽内部，热软化磁球均匀设置于多孔导热隔板远离外透气膜的一侧，热软化磁球与感知槽顶壁之间固定连接有弹性拉绳，在发生密封失效后，外界空气进入到试管内，然后通过外透气膜进入到内侧，并与自发热材料进行反应产生热量，热量通过多孔导热隔板传导至热软化磁球上，从而促使其软化，进而在磁吸层的磁吸作用力下穿过多孔导热隔板，顶起外透气膜向下侧膨胀预警。
(4)本方案中诊断试剂的高度低于外透气膜的最大形变长度，试管内其余空间填充有氮气，一方面对诊断试剂进行保护，另一方面不易对感知自热囊造成误干扰。
(5)本方案中热软化磁球包括形变外衣、热熔夹层以及磁性内芯，磁性内芯设置于形变外衣内部，热熔夹层填充于形变外衣和磁性内芯之间，热熔 夹层正常状态下对热软化磁球的整体形状进行支撑，从而不易从多孔导热隔板中穿过，在发生密封失效后空气进入，进而发生反应产生热量促使热熔夹层熔化，进而磁性内芯在磁吸层的磁吸作用下穿过多孔导热隔板向下移动，迫使多孔导热隔板向下侧膨胀预警。
(6)本方案中多孔导热隔板的网孔直径小于热软化磁球的直径并大于热熔夹层的直径，形变外衣外侧涂覆有彩漆层，具有彩漆层的形变外衣在推动外透气膜发生膨胀后，对技术人员的可视化预警效果更好。
附图说明
图1为本发明的结构示意图；
图2为本发明的剖视图；
图3为本发明试管部分正常状态下的结构示意图；
图4为本发明密封塞的结构示意图；
图5为本发明热软化磁球的结构示意图；
图6为本发明试管部分漏气状态下的结构示意图。
图中标号说明：
1盒身、11外盒、12海绵垫、13磁吸层、2盒盖、3包封条、4可视窗、5固定板、6弹性伸缩杆、7密封塞、8试管、9感知自热囊、91外透气膜、92多孔导热隔板、93热软化磁球、931形变外衣、932热熔夹层、933磁性内芯。
具体实施方式
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述；显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例，基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
在本发明的描述中，需要说明的是，术语“上”、“下”、“内”、“外”、 “顶/底端”等指示的方位或位置关系为基于附图所示的方位或位置关系，仅是为了便于描述本发明和简化描述，而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本发明的限制。此外，术语“第一”、“第二”仅用于描述目的，而不能理解为指示或暗示相对重要性。
在本发明的描述中，需要说明的是，除非另有明确的规定和限定，术语“安装”、“设置有”、“套设/接”、“连接”等，应做广义理解，例如“连接”，可以是固定连接，也可以是可拆卸连接，或一体地连接；可以是机械连接，也可以是电连接；可以是直接相连，也可以通过中间媒介间接相连，可以是两个元件内部的连通。对于本领域的普通技术人员而言，可以具体情况理解上述术语在本发明中的具体含义。
实施例1：
请参阅图1-3，一种肿瘤细胞辅助诊断试剂盒，包括盒身1，盒身1上侧转动连接有相匹配的盒盖2，盒身1和盒盖2之间粘接有相匹配的包封条3，盒身1内侧设有固定板5，固定板5与盒身1底部之间固定连接有多根均匀分布的弹性伸缩杆6，固定板5下端固定连接有多个均匀分布的密封塞7，密封塞7下端螺纹连接有相匹配的试管8，试管8内盛放有肿瘤细胞的诊断试剂，诊断试剂为现有产品，具体成分在此不再赘述，密封塞7和试管8之间包裹有10，密封塞7下端开设有感知槽，感知槽内安装有感知自热囊9。
试管8和外透气膜91均为透明材质，盒盖2前端镶嵌连接有相对应的可视窗4。
请参阅图2，盒身1包括外盒11、海绵垫12以及磁吸层13，磁吸层13固定连接于外盒11内底端，海绵垫12固定连接于磁吸层13上端，海绵垫12上端开设有多个与试管8相匹配的软定位槽，海绵垫12起到对试管8的保护作用，磁吸层13则可以在感知自热囊9感知到密封失效后，主动施加磁吸力 进行干预，提高感知自热囊9的膨胀的程度来促进预警效果。
弹性伸缩杆6处于压缩状态，且弹性伸缩杆6延伸后的高度高于盒身1的高度，可以在打开盒盖2后通过弹性伸缩杆6主动顶起固定板5，进而方便取下试管8进行诊断使用。
请参阅图4，感知自热囊9包括外透气膜91、多孔导热隔板92以及多个热软化磁球93，外透气膜91固定连接于感知槽的槽口处，多孔导热隔板92固定连接于感知槽内部，热软化磁球93均匀设置于多孔导热隔板92远离外透气膜91的一侧，热软化磁球93与感知槽顶壁之间固定连接有弹性拉绳，在发生密封失效后，外界空气进入到试管8内，然后通过外透气膜91进入到内侧，并与自发热材料进行反应产生热量，热量通过多孔导热隔板92传导至热软化磁球93上，从而促使其软化，进而在磁吸层13的磁吸作用力下穿过多孔导热隔板92，顶起外透气膜91向下侧膨胀预警。
外透气膜91为弹性的防水透气膜，外透气膜91和多孔导热隔板92之间填充有自发热材料。
诊断试剂的高度低于外透气膜91的最大形变长度，试管8内其余空间填充有氮气，一方面对诊断试剂进行保护，另一方面不易对感知自热囊9造成误干扰。
请参阅图5，热软化磁球93包括形变外衣931、热熔夹层932以及磁性内芯933，磁性内芯933设置于形变外衣931内部，热熔夹层932填充于形变外衣931和磁性内芯933之间，热熔夹层932正常状态下对热软化磁球93的整体形状进行支撑，从而不易从多孔导热隔板92中穿过，在发生密封失效后空气进入，进而发生反应产生热量促使热熔夹层932熔化，进而磁性内芯933在磁吸层13的磁吸作用下穿过多孔导热隔板92向下移动，迫使多孔导热隔板92向下侧膨胀预警。
形变外衣931采用弹性导热材料制成，热熔夹层932采用低熔点的热熔 性材料制成，且熔点高于室温。
多孔导热隔板92的网孔直径小于热软化磁球93的直径并大于热熔夹层932的直径，形变外衣931外侧涂覆有彩漆层，具有彩漆层的形变外衣931在推动外透气膜91发生膨胀后，对技术人员的可视化预警效果更好。
请参阅图6，本发明可以实现采用特殊的密封方式，依靠密封塞7和试管8之间的螺纹密封来实现试剂的方便取用，同时利用密封塞7内的感知自热囊9对密封性进行感知，当出现密封性失效的时候，外界的空气首先进入到试管8内，密封塞7内的感知自热囊9可以及时的感知到空气中的氧气并与其发生反应来产生热量，进而促使感知自热囊9部分熔化，进而在磁吸作用下发生向下膨胀动作，依靠视觉上的变化来对技术人员进行密封预警，可以有效避免受到污染的试剂被误用，提高试剂诊断的可信度以及安全性。
以上所述，仅为本发明较佳的具体实施方式；但本发明的保护范围并不局限于此。任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，根据本发明的技术方案及其改进构思加以等同替换或改变，都应涵盖在本发明的保护范围内。

Claims (10)

  1. 一种肿瘤细胞辅助诊断试剂盒，包括盒身(1)，其特征在于：所述盒身(1)上侧转动连接有相匹配的盒盖(2)，所述盒身(1)和盒盖(2)之间粘接有相匹配的包封条(3)，所述盒身(1)内侧设有固定板(5)，所述固定板(5)与盒身(1)底部之间固定连接有多根均匀分布的弹性伸缩杆(6)，所述固定板(5)下端固定连接有多个均匀分布的密封塞(7)，所述密封塞(7)下端螺纹连接有相匹配的试管(8)，所述试管(8)内盛放有肿瘤细胞的诊断试剂，所述密封塞(7)和试管(8)之间包裹有(10)，所述密封塞(7)下端开设有感知槽，所述感知槽内安装有感知自热囊(9)。
  2. 根据权利要求1所述的一种肿瘤细胞辅助诊断试剂盒，其特征在于：所述盒身(1)包括外盒(11)、海绵垫(12)以及磁吸层(13)，所述磁吸层(13)固定连接于外盒(11)内底端，所述海绵垫(12)固定连接于磁吸层(13)上端，所述海绵垫(12)上端开设有多个与试管(8)相匹配的软定位槽。
  3. 根据权利要求1所述的一种肿瘤细胞辅助诊断试剂盒，其特征在于：所述弹性伸缩杆(6)处于压缩状态，且弹性伸缩杆(6)延伸后的高度高于盒身(1)的高度。
  4. 根据权利要求1所述的一种肿瘤细胞辅助诊断试剂盒，其特征在于：所述感知自热囊(9)包括外透气膜(91)、多孔导热隔板(92)以及多个热软化磁球(93)，所述外透气膜(91)固定连接于感知槽的槽口处，所述多孔导热隔板(92)固定连接于感知槽内部，所述热软化磁球(93)均匀设置于多孔导热隔板(92)远离外透气膜(91)的一侧，所述热软化磁球(93)与感知槽顶壁之间固定连接有弹性拉绳。
  5. 根据权利要求4所述的一种肿瘤细胞辅助诊断试剂盒，其特征在于：所述外透气膜(91)为弹性的防水透气膜，所述外透气膜(91)和多孔导热隔板(92)之间填充有自发热材料。
  6. 根据权利要求4所述的一种肿瘤细胞辅助诊断试剂盒，其特征在于：所述诊断试剂的高度低于外透气膜(91)的最大形变长度，所述试管(8)内其余空间填充有氮气。
  7. 根据权利要求4所述的一种肿瘤细胞辅助诊断试剂盒，其特征在于：所述热软化磁球(93)包括形变外衣(931)、热熔夹层(932)以及磁性内芯(933)，所述磁性内芯(933)设置于形变外衣(931)内部，所述热熔夹层(932)填充于形变外衣(931)和磁性内芯(933)之间。
  8. 根据权利要求7所述的一种肿瘤细胞辅助诊断试剂盒，其特征在于：所述形变外衣(931)采用弹性导热材料制成，所述热熔夹层(932)采用低熔点的热熔性材料制成，且熔点高于室温。
  9. 根据权利要求8所述的一种肿瘤细胞辅助诊断试剂盒，其特征在于：所述多孔导热隔板(92)的网孔直径小于热软化磁球(93)的直径并大于热熔夹层(932)的直径，所述形变外衣(931)外侧涂覆有彩漆层。
  10. 根据权利要求4所述的一种肿瘤细胞辅助诊断试剂盒，其特征在于：所述试管(8)和外透气膜(91)均为透明材质，所述盒盖(2)前端镶嵌连接有相对应的可视窗(4)。
PCT/CN2022/135780 2022-06-22 2022-12-01 一种肿瘤细胞辅助诊断试剂盒 WO2023245992A1 (zh)

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