WO2023234381A1 - 移送器具 - Google Patents
移送器具 Download PDFInfo
- Publication number
- WO2023234381A1 WO2023234381A1 PCT/JP2023/020397 JP2023020397W WO2023234381A1 WO 2023234381 A1 WO2023234381 A1 WO 2023234381A1 JP 2023020397 W JP2023020397 W JP 2023020397W WO 2023234381 A1 WO2023234381 A1 WO 2023234381A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- shaft
- pressing
- transfer device
- outer cylinder
- medical sheet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00064—Constructional details of the endoscope body
- A61B1/00071—Insertion part of the endoscope body
- A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
- A61B1/00087—Tools
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0095—Packages or dispensers for prostheses or other implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
- A61B2017/00292—Surgical instruments, devices or methods for minimally invasive surgery mounted on or guided by flexible, e.g. catheter-like, means
- A61B2017/00296—Surgical instruments, devices or methods for minimally invasive surgery mounted on or guided by flexible, e.g. catheter-like, means mounted on an endoscope
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00681—Aspects not otherwise provided for
- A61B2017/00738—Aspects not otherwise provided for part of the tool being offset with respect to a main axis, e.g. for better view for the surgeon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00969—Surgical instruments, devices or methods used for transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
- A61F2002/0072—Delivery tools therefor
Definitions
- the present invention relates to a transfer device.
- Japanese Patent Application Publication No. 2009-511 discloses a transfer device for transferring a medical sheet (cell sheet) used for organ transplantation to a treatment target part of a living body.
- This transfer device includes a shaft and a support provided at the distal end of the shaft.
- the support portion has a support surface on which a medical sheet is placed.
- the medical sheet is transferred from the support portion to the treatment target area by sliding the transfer device while pressing the top surface of the medical sheet placed on the support surface with forceps or the like.
- the present invention aims to solve the above-mentioned problems.
- One aspect of the present invention is a transfer device for transferring a medical sheet to a treatment target part of a living body, which includes a first shaft and a distal end portion of the first shaft provided with the medical sheet.
- a first carrier member including a support portion having a support surface on which is placed; a second shaft extending along the axial direction of the first shaft; and a press provided at the tip of the second shaft. and a second carrier member, the second carrier member being able to press the outer peripheral end surface of the medical sheet placed on the support surface in the distal direction with the pressing surface of the pressing section.
- a transfer device movable relative to the first carrier member in such a manner that the transfer device is movable relative to the first carrier member;
- the medical sheet by pressing the outer circumferential end surface of the medical sheet placed on the support surface of the first carrier member in the distal direction by the pressing surface of the pressing part, the medical sheet is moved from the support surface to the biological body. It can be slid to the target area. Thereby, the medical sheet can be efficiently transported to the treatment target area.
- the pressing surface may extend upward to be inclined toward the distal end.
- the pressing portion may be formed to have a wider width toward the distal end when viewed from above.
- the pressing surface may be curved in an arc shape toward the proximal end when viewed from above.
- the transfer device includes an outer cylinder through which the first shaft is inserted, and the support portion is flexible and formed in a sheet shape.
- the support part is formed wider than the inner diameter of the outer cylinder, and the support part and the medical sheet move the first shaft and the second shaft in a proximal direction with respect to the outer cylinder.
- the supporting portion and the medical sheet are stored in the outer cylinder in a curved and deformed state, and the support portion and the medical sheet are stored in the outer cylinder in a curved and deformed state, and the first shaft and the second shaft are placed in the outer cylinder with respect to the outer cylinder. It may be expanded by moving it toward the distal end and exposing it from the outer tube.
- the maximum width of the pressing portion may be smaller than the width of the supporting portion and larger than the outer diameter of the second shaft.
- FIG. 1 is a perspective view of a transfer device according to an embodiment of the invention.
- 2 is an exploded perspective view of the transfer device of FIG. 1;
- FIG. 3 is a plan view of the distal end of the transfer instrument of FIG. 1;
- FIG. 4 is a longitudinal cross-sectional view taken along line IV-IV in FIG. 3.
- FIG. 5 is a cross-sectional view taken along line VV in FIG. 3.
- FIG. 6 is a flowchart showing the steps of a method for transporting a medical sheet using the transport device of FIG.
- FIG. 7 is a first explanatory diagram of the sheet mounting process.
- FIG. 8 is a second explanatory diagram of the sheet mounting process.
- FIG. 9 is an explanatory diagram of the storage process.
- FIG. 7 is a first explanatory diagram of the sheet mounting process.
- FIG. 8 is a second explanatory diagram of the sheet mounting process.
- FIG. 9 is an explanatory diagram of the storage process.
- FIG. 10 is a cross-sectional view taken along line XX in FIG. 9.
- FIG. 11 is a cross-sectional view taken along line XI-XI in FIG. 9.
- FIG. 12 is an explanatory diagram of the arrangement process.
- FIG. 13 is an explanatory diagram of the unfolding process.
- FIG. 14 is a first explanatory diagram of the moving process.
- FIG. 15 is a second explanatory diagram of the moving process.
- FIG. 16A is a partially omitted schematic diagram of a transfer instrument including an instrument main body according to a first modification.
- FIG. 16B is a cross-sectional view taken along line XVIB-XVIB in FIG. 16A.
- FIG. 17 is an explanatory diagram of the second carrier member in FIG. 16A moved toward the distal end.
- FIG. 16A is a partially omitted schematic diagram of a transfer instrument including an instrument main body according to a first modification.
- FIG. 16B is a cross-sectional view taken
- FIG. 18 is a partially omitted perspective view of the second carrier member including the pressing portion according to the first configuration example.
- FIG. 19 is a partially omitted perspective view of a second carrier member including a pressing portion according to a second configuration example.
- FIG. 20 is a partially omitted perspective view of a second carrier member including a pressing portion according to a third configuration example.
- FIG. 21 is a perspective view of a transfer device including a device main body according to a second modification.
- FIG. 22 is a cross-sectional view of the transfer device shown in FIG. 21, with the support section housed in the outer cylinder.
- a transfer instrument 10 is a medical device for transferring a medical sheet 300 to a treatment target part of a living body.
- the transfer device 10 is used, for example, to treat severe heart failure due to ischemic heart disease.
- the medical sheet 300 is transplanted to the transplant target part 402 (the treatment target part of the living body) of the heart 400 (see FIGS. 12 to 15).
- a plurality of medical sheets 300 can be attached to the transplant target region 402.
- Such a medical sheet 300 includes pharmaceuticals for medical use, regenerative medicine products, medical devices, and the like.
- the medical sheet 300 is formed into a sheet shape such as a film or a membrane (a highly viscous object).
- the medical sheet 300 may be reinforced by applying fibrin or the like.
- Regenerative medicine products containing cells include, for example, cell sheets (sheet-shaped cell cultures), spheroids, and the like.
- a cell sheet can be formed by culturing autologous cells or allogeneic cells.
- the cells that make up the cell sheet are, for example, somatic stem cells (adult stem cells), mesenchymal stem cells, or iPS cells (induced pluripotent stem cells). Stem Cells)-derived cardiomyocytes.
- Somatic stem cells preferably include skeletal myoblasts (myoblast cells).
- the medical sheet 300 may contain a tissue adhesive, a local anesthetic, and the like.
- the thickness of the medical sheet 300 is, for example, about 100 ⁇ m, and the diameter of the medical sheet 300 is, for example, about 60 mm. However, the thickness and diameter (size) of the medical sheet 300 can be set as appropriate.
- the medical sheet 300 may be a sheet that is transplanted into an organ other than the heart 400 (eg, lung, liver, pancreas, kidney, small intestine, esophagus, etc.). Moreover, the medical sheet 300 may be a sheet for preventing adhesion, for example, as long as it is used for medical purposes.
- an organ other than the heart 400 eg, lung, liver, pancreas, kidney, small intestine, esophagus, etc.
- the medical sheet 300 may be a sheet for preventing adhesion, for example, as long as it is used for medical purposes.
- the transfer instrument 10 includes an instrument body 12, an endoscope 14, and a fixing member 16.
- the instrument body 12 has a first carrier member 18, a second carrier member 20, and an outer barrel 22.
- the first carrier member 18 has a first shaft 24 and a support portion 26.
- the first shaft 24 is a circular tube member having a first inner cavity 28.
- the first inner cavity 28 opens at the distal end of the first shaft 24 (the end in the direction of arrow X1) and at the base end of the first shaft 24 (the end in the direction of arrow X2).
- the first shaft 24 is made of, for example, a resin material.
- the constituent materials of the first shaft 24 include, but are not limited to, polyethylene, polypropylene, fluororesin, polyethylene terephthalate, polymethyl methacrylate, polyamide resin, polystyrene, polycarbonate, polyimide, polyetherimide, polyetheretherketone, polyvinyl chloride, Examples include ABS resin.
- the first shaft 24 may be made of a metal material.
- the first shaft 24 may have flexibility.
- the first shaft 24 may include a flexible tube portion that can maintain a bent shape.
- the first shaft 24 can be bent into an appropriate shape within the body cavity, and the bent shape can be maintained.
- the flexible tube section is configured, for example, by forming the tube wall section into a bellows shape.
- the flexible tube portion may be made of a material that can maintain a bent shape.
- the flexible tube portion can be formed, for example, by inserting a linear metal member that can maintain a bent shape into the lumen of the first shaft 24 made of resin.
- the flexible tube portion forms only a portion of the first shaft 24 in the longitudinal direction. However, the flexible tube portion may form the entire first shaft 24.
- the support portion 26 is attached to the tip of the first shaft 24.
- the support portion 26 is made of, for example, a resin material.
- the constituent material of the support part 26 is not particularly limited, but preferably has transparency, and examples thereof include polycarbonate, polyamide, polystyrene, polypropylene, polyacetal resin, polyimide, polyether ether ketone, polyethylene terephthalate, fluororesin, and the like.
- the support portion 26 has flexibility.
- the support portion 26 is formed by bending a resin sheet material (film material) into a predetermined shape.
- the support portion 26 is formed, for example, by molding a sheet material into a predetermined shape using a sheet mold.
- the thickness of the sheet material is not particularly limited, but is preferably set to, for example, 100 ⁇ m or more and 200 ⁇ m or less.
- the support part 26 has a joint part 30 and a support body 32.
- the joint portion 30 is bonded to the inner circumferential surface of the distal end portion of the first shaft 24 with an adhesive.
- the adhesive include, but are not particularly limited to, UV adhesives, instant adhesives (for example, cyanoacrylate instant adhesives), and the like.
- the joint portion 30 may be heat-sealed to the inner circumferential surface of the first shaft 24 .
- the first shaft 24 can be smoothly inserted into the outer cylinder 22 because no step is formed by the joining part 30 on the outer peripheral surface of the first shaft 24. can be inserted.
- the joint portion 30 may be joined to the lower surface (the outer surface facing the direction of arrow Y1) of the distal end portion of the first shaft 24.
- the support body 32 extends in the distal direction from the joint portion 30 (see FIG. 4).
- the support body 32 has a proximal support part 34, a pair of first protrusions 36, an intermediate support part 38, a pair of second protrusions 40, a pair of third protrusions 42, and a distal support part 44.
- the base end support portion 34 extends from the distal end of the joint portion 30 toward the distal end so as to generally follow the axis Ax of the first shaft 24 (see FIG. 4).
- the proximal support portion 34 is formed to be wide in its extending direction. In other words, both sides of the base end support portion 34 in the width direction are tapered toward the joint portion 30 .
- the pair of first protrusions 36 protrude upward (in the direction of arrow Y2) from both sides of the base end supporter 34.
- the intermediate support portion 38 extends from the distal end of the base end support portion 34 toward the distal end so as to be inclined in a direction approaching the axis Ax of the first shaft 24 (see FIG. 4).
- the intermediate support portion 38 has a substantially constant width over its entire length. However, the intermediate support portion 38 may be formed to be wide or narrow toward the distal end.
- the pair of second protrusions 40 are connected to the tips of the pair of first protrusions 36, respectively.
- the pair of second protrusions 40 protrude upward from both sides of the intermediate support section 38 in the width direction and inward in the width direction of the intermediate support section 38 .
- the pair of third protrusions 42 are connected to the tips of the pair of second protrusions 40, respectively.
- the pair of third protruding parts 42 protrude upward from both sides of the intermediate support part 38 in the width direction and outward in the width direction of the intermediate support part 38 .
- the tip support portion 44 is connected to the tip of the intermediate support portion 38 and the tip of the pair of third protrusions 42 .
- the distal end support portion 44 protrudes in an arc shape toward the distal end. In other words, the distal end support portion 44 is formed to become narrower toward the distal end.
- the support body 32 has a support surface 46 facing upward.
- the support surface 46 is formed by the upper surface of the intermediate support section 38, the upper surface of the tip support section 44, and the upper surface of the pair of third protrusions 42.
- a lubricant may be applied to the support surface 46 so that a pressing portion 50 of the second carrier member 20, which will be described later, can smoothly slide with respect to the support surface 46.
- a portion of the support surface 46 formed by the upper surface of the intermediate support portion 38 and the upper surface of the tip support portion 44 is a flat surface (see FIG. 4).
- the portion of the support surface 46 formed by the upper surface of the intermediate support portion 38 and the upper surface of the tip support portion 44 may be a curved surface that is curved so as to protrude in a direction opposite to the direction of the support surface 46. good.
- the second carrier member 20 includes a second shaft 54, a pressing portion 50, and a connector 52.
- the second shaft 54 is a circular tube member having a second inner cavity 57.
- the second inner cavity 57 opens at the distal end of the second shaft 54 (the end in the direction of arrow X1) and at the base end of the second shaft 54 (the end in the direction of arrow X2).
- the length of the second shaft 54 along the axial direction is longer than the length of the first shaft 24 along the axial direction.
- the second shaft 54 is inserted into the first inner cavity 28 of the first shaft 24 (see FIGS. 1 and 4).
- the distal end portion of the second shaft 54 projects from the distal opening of the first shaft 24 in the distal direction.
- the proximal end portion of the second shaft 54 protrudes in the proximal direction from the proximal opening of the first shaft 24 (see FIG. 1).
- the second shaft 54 is configured to follow the shape (inclination) of the support portion 26.
- the constituent material of the second shaft 54 for example, a material that is more flexible than the constituent material of the first shaft 24 is selected.
- the constituent material of the second shaft 54 include polyamide elastomer, polyester elastomer, polyurethane elastomer, polyvinyl chloride, polybutadiene, silicone rubber, metal coil (including composites with resin), and the like.
- the second shaft 54 has flexibility. Note that when the first shaft 24 has a flexible tube portion, the second shaft 54 bends along the bent shape of the first shaft 24. A pressing portion 50 is attached to the tip of the second shaft 54 .
- the pressing portion 50 is formed with an insertion hole 58, a pressing surface 64, and a supply hole 66.
- the distal end portion of the second shaft 54 is inserted into the insertion hole 58 .
- the tip of the second shaft 54 is heat-sealed to the inner surface forming the insertion hole 58.
- the tip of the second shaft 54 may be joined to the inner surface forming the insertion hole 58 with an adhesive.
- the pressing portion 50 is formed to become wider toward the distal end when viewed from above.
- the pressing portion 50 is formed into a trapezoidal shape when viewed from above.
- the pressing surface 64 is provided on the distal end surface of the pressing portion 50.
- the pressing surface 64 presses the outer peripheral end surface 302 (see FIG. 14) of the medical sheet 300 in the distal direction.
- the pressing surface 64 extends upward so as to be inclined in the tip direction (arrow X1 direction).
- the pressing surface 64 is a flat surface.
- the supply hole 66 communicates with the second lumen 57 of the second shaft 54 and is open to the pressing surface 64.
- the supply hole 66 and the second lumen 57 communicate with each other to form a liquid supply channel 68 .
- the liquid supply channel 68 leads out a liquid for preventing the medical sheet 300 from drying toward the distal end of the pressing section 50 .
- the liquid for example, physiological saline is used.
- the connector 52 is attached to the proximal end of the second shaft 54.
- the connector 52 is configured as a so-called straight type connector.
- the connector 52 includes a connection port portion 82 to which a liquid supply device (not shown) can be attached and detached.
- the outer cylinder 22 is a cylindrical member having an inner cavity 84.
- the inner cavity 84 opens at the distal end of the outer cylinder 22 (the end in the direction of the arrow X1) and at the base end of the outer cylinder 22 (the end in the direction of the arrow X2).
- the outer cylinder 22 has flexibility.
- the constituent material of the outer cylinder 22 includes the same material as the constituent material of the first shaft 24 described above. Note that when the first shaft 24 has a flexible tube portion, the outer cylinder 22 bends along the bent shape of the first shaft 24. Further, in this embodiment, the outer tube 22 may have a flexible tube portion as described above. In this case, the first shaft 24 does not need to have a flexible tube portion.
- the first shaft 24 is inserted into the inner cavity 84 of the outer cylinder 22.
- the length of the outer cylinder 22 along the axial direction is shorter than the length of the first shaft 24 along the axial direction. 3 and 4, the inner diameter D1 of the outer cylinder 22 is smaller than the width W1 of the intermediate support portion 38.
- the width W1 of the intermediate support part 38 is set to the width W1 of the inner surface of the outer cylinder 22 so that the support part 26 can be stored in the outer cylinder 22 in a cylindrical shape along the circumferential direction of the inner peripheral surface of the outer cylinder 22.
- the length is substantially the same as the circumference.
- the width W1 may be shorter or longer than the circumferential length of the inner surface of the outer tube 22 as long as the support portion 26 can be accommodated within the outer tube 22.
- the maximum width W2 of the pressing portion 50 is smaller than the inner diameter D1 of the outer cylinder 22 and larger than the outer diameter of the second shaft 54. Thereby, the pressing part 50 can be made relatively wide, and the pressing part 50 can be easily accommodated in the outer cylinder 22.
- the maximum width W2 of the pressing portion 50 is smaller than the width W1 of the intermediate support portion 38 and larger than the outer diameter of the second shaft 54.
- the distal end surface of the outer cylinder 22 extends along a direction perpendicular to the axial direction of the outer cylinder 22.
- the distal end surface of the outer cylinder 22 may extend upward and be inclined in the proximal direction. In this case, for example, in thoracoscopic surgery, it becomes easier to insert the outer tube 22 into the incision 409 (FIG. 12) in the chest 408. Further, the slope of the distal end surface of the outer cylinder 22 serves as an indicator for the operator to recognize the upper surface of the support portion 26.
- the endoscope 14 has a long endoscope main body 86.
- the distal end portion of the endoscope main body 86 is fixed to the outer peripheral surface of the outer tube 22 by the fixing member 16.
- An objective lens 88 provided on the distal end surface of the endoscope main body 86 faces toward the distal end of the outer tube 22 (in the direction of arrow X1).
- a distal end portion of the endoscope main body 86 is fixed to an intermediate portion of the outer tube 22 in the axial direction.
- the distal end of the endoscope main body 86 may be fixed to the distal end of the outer cylinder 22.
- the fixing member 16 includes, for example, a fixing cylinder 87 and a fixing tube 89.
- the fixed cylinder 87 is made of, for example, a hard resin material.
- the endoscope main body 86 can be inserted into the inner cavity of the fixed tube 87.
- the fixed cylinder 87 is arranged along the longitudinal direction of the outer cylinder 22.
- the fixed tube 89 is a tube for fixing the fixed cylinder 87 to a predetermined position of the outer cylinder 22.
- the fixed tube 89 is, for example, a heat shrink tube. Note that the outer cylinder 22 and the fixed cylinder 87 may be integrally molded. However, the method of fixing the distal end of the endoscope main body 86 to the outer tube 22 can be set as appropriate.
- the transfer method includes a preparation process, a sheet placement process, a storage process, a placement process, a development process, a movement process, and a removal process.
- step S1 the transfer instrument 10 according to the present embodiment described above is prepared.
- the transfer device 10 is initially in a state as shown in FIG. 1 . That is, the support portion 26 is made to protrude from the distal end opening of the outer tube 22 in the distal direction.
- the pressing part 50 is located on the support surface 46. Further, the base end portion of the pressing portion 50 is inserted into the first inner cavity 28 of the first shaft 24 .
- the medical sheet 300 cultured in the petri dish 401 is mounted on the support surface 46.
- the pair of second protrusions 40 suppress the movement (misalignment) of the medical sheet 300 in the width direction of the intermediate support section 38 when the medical sheet 300 is placed on the support surface 46 .
- the medical sheet 300 is stored in the outer cylinder 22 together with the support section 26. Specifically, the first shaft 24 of the first carrier member 18 and the second shaft 54 of the second carrier member 20 are moved together in the proximal direction with respect to the outer cylinder 22 .
- the proximal support portion 34 is drawn in from the distal opening of the outer tube 22 toward the proximal end.
- the tapered both sides of the proximal support part 34 come into contact with the distal end surface of the outer cylinder 22, so that the proximal support part 34 is attached to the proximal support part 34 along the circumferential direction of the outer cylinder 22.
- a force that tries to curl up acts. Therefore, the base end support portion 34 is smoothly drawn into the outer cylinder 22 while being rounded.
- the intermediate support portion 38 When the proximal support portion 34 is deformed, a force that tends to curl the intermediate support portion 38 along the circumferential direction of the outer tube 22 acts on the intermediate support portion 38, so that the intermediate support portion 38 is drawn into the outer tube 22 while being curled.
- the width W1 of the intermediate support part 38 is substantially the same length as the circumferential length of the inner surface of the outer cylinder 22, the intermediate support part 38 deforms into a cylindrical shape along the inner surface of the outer cylinder 22. .
- the medical sheet 300 is inserted into the outer cylinder 22 while being deformed into a shape corresponding to the shape of the support body 32.
- the storage process is completed when the entire support portion 26 is completely inserted into the outer tube 22, as shown in FIG.
- the pair of third protrusions 42 extend downward (in the direction of arrow Y1) from the upper end of the outer tube 22 while in contact with each other.
- the protruding end surfaces of the pair of third protrusions 42 are spaced apart from the medical sheet 300.
- the medical sheet 300 deforms along the shape of the support portion 26. In other words, the medical sheet 300 does not fold and overlap inside the outer tube 22.
- the transfer instrument 10 is inserted into the thoracic cavity 410 through the incision 409 in the chest 408, as shown in FIG.
- the distal end of the transfer instrument 10 is positioned near the transplant target portion 402 in the heart 400, and the distal end of the endoscope 14 is positioned within the thoracic cavity 410.
- a liquid supply device (not shown) may be connected to the connection port portion 82 of the connector 52 to introduce a liquid (eg, physiological saline).
- the liquid introduced from the connection port portion 82 is guided to the medical sheet 300 through the liquid supply channel 68 (second lumen 57 and supply hole 66). Thereby, drying of the medical sheet 300 can be suppressed.
- the support portion 26 and the medical sheet 300 are unfolded, as shown in FIG. 13.
- the first shaft 24 and the second shaft 54 are moved toward the distal end with respect to the outer cylinder 22.
- the support portion 26 exposed from the tip opening of the outer cylinder 22 returns to its original shape due to the restoring force.
- the medical sheet 300 expands into a planar shape.
- step S6 in FIG. 6 the second shaft 54 is moved in the distal direction relative to the first shaft 24, so that the second shaft 54 is placed on the support surface 46.
- the portion of the outer peripheral end surface 302 of the medical sheet 300 facing toward the proximal end is pressed toward the distal end by the pressing surface 64.
- the pressing portion 50 slides on the support surface 46 in the distal direction.
- the medical sheet 300 pressed by the pressing section 50 slides toward the distal end on the support surface 46 while maintaining its shape. Thereby, the medical sheet 300 can be smoothly moved from the support surface 46 to the transplant target part 402 of the heart 400.
- step S7 in FIG. 6 the transfer device 10 is removed from the chest 408 with the support portion 26 and the pressing portion 50 housed in the outer cylinder 22.
- the transfer device 10 according to this embodiment has the following effects.
- the medical sheet 300 by pressing the outer peripheral end surface 302 of the medical sheet 300 placed on the support surface 46 of the first carrier member 18 in the distal direction by the pressing surface 64 of the pressing section 50, the medical sheet 300 can be slid from the support surface 46 into the transplant target portion 402 of the heart 400. Thereby, the medical sheet 300 can be efficiently transferred to the transplant target area 402.
- the first shaft 24 is formed into a tubular shape.
- the second shaft 54 is inserted into the first inner cavity 28 of the first shaft 24 so as to be movable along the axial direction of the first shaft 24 .
- the transfer instrument 10 can be made more compact than when the second shaft 54 is disposed outside the first shaft 24.
- the pressing part 50 slides on the support surface 46 when pressing the outer peripheral end surface 302 of the medical sheet 300 in the distal direction with the pressing surface 64.
- the outer peripheral end surface 302 of the medical sheet 300 placed on the support surface 46 can be efficiently pressed by the pressing surface 64.
- the second carrier member 20 has a liquid supply channel 68 for supplying liquid to the medical sheet 300 placed on the support surface 46.
- the pressing surface 64 extends upward and tilts toward the tip.
- the pressing portion 50 is formed to become wider toward the distal end when viewed from above.
- the area of the pressing surface 64 can be easily expanded.
- the transfer instrument 10 includes an outer cylinder 22 into which a first shaft 24 is inserted.
- the support portion 26 has flexibility and is formed into a sheet shape.
- the support portion 26 is formed wider than the inner diameter D1 of the outer cylinder 22.
- the support part 26 and the medical sheet 300 are curved and deformed along the circumferential direction of the outer cylinder 22 by moving the first shaft 24 and the second shaft 54 in the proximal direction relative to the outer cylinder 22. It is stored in 22.
- the support part 26 and the medical sheet 300 housed in the outer cylinder 22 are expanded by moving the first shaft 24 and the second shaft 54 in the distal direction relative to the outer cylinder 22 and exposing them from the outer cylinder 22. .
- the outer cylinder 22 is removed from the incision 409 of the chest 408 with the support part 26 and the medical sheet 300 stored in the outer cylinder 22. It can be inserted into the thoracic cavity 410 (body cavity).
- the body cavity includes a thoracic cavity 410 and an abdominal cavity.
- the support portion 26 and the medical sheet 300 can be expanded.
- the medical sheet 300 having a diameter larger than the inner diameter D1 of the outer cylinder 22 can be placed in a position adjacent to the transplant target part 402 of the heart 400 (the treatment target part of the living body).
- the maximum width W2 of the pressing portion 50 is smaller than the width of the support portion 26 (width W1 of the intermediate support portion 38) and larger than the outer diameter of the second shaft 54.
- the pressing surface 64 can be made relatively wide.
- the support portion 26 has a pair of second protrusions 40 that protrude upward from both sides of the support surface 46 in the width direction.
- the pair of second protrusions 40 can prevent the medical sheet 300 from falling to the outside of the support body 32.
- the transfer instrument 10 further includes an endoscope 14 for photographing the support section 26, the pressing section 50, and the medical sheet 300.
- the transfer instrument 10 may include an instrument main body 12a according to a first modification.
- the same reference numerals are given to the same structure as the instrument main body 12 mentioned above, and the detailed description of the said same structure is abbreviate
- the instrument body 12a includes a first carrier member 18a, a second carrier member 20a, and an outer cylinder 22.
- the first carrier member 18a has a first shaft 24a and a support portion 26 (see FIG. 2).
- An insertion slit 100 is formed at the base end of the first shaft 24a.
- the insertion slit 100 communicates with the first lumen 28 of the first shaft 24a.
- the insertion slit 100 radially penetrates the peripheral wall portion of the first shaft 24a.
- the insertion slit 100 extends along the axial direction of the outer cylinder 22.
- the width W3 of the insertion slit 100 is smaller than the outer diameter D2 of the second shaft 54, which will be described later (see FIG. 16B).
- the second carrier member 20a has a second shaft 54 and a connector 52a.
- the base end of the second shaft 54 is sealed so that the second lumen 57 does not communicate with the outside.
- the connector 52a passes through the insertion slit 100 and extends radially outward from the base end of the second shaft 54.
- the connector 52a includes a connection port portion 82a exposed to the outside of the first shaft 24a.
- the connector 52a moves in the insertion slit 100 in the distal direction.
- the overall length of the transfer device 10 can be shortened.
- the second carrier member 20 may include a pressing portion 50a according to the first configuration example instead of the pressing portion 50 described above.
- the pressing portion 50a is formed to become wider toward the distal end. Specifically, the pressing portion 50a extends on both sides in the width direction toward the distal end. Both side surfaces 51 in the width direction of the pressing portion 50a are flat surfaces tapered toward the proximal direction (towards the second shaft 54). However, each side surface 51 may be a curved surface curved outward in the width direction in an arc shape. Both widthwise outer ends 53 of the pressing portion 50a are curved in an arc shape (semicircular shape) when viewed from above. The pressing portion 50a is formed symmetrically with respect to the axis of the second shaft 54. A pressing surface 64a facing toward the tip is provided at the tip of the pressing portion 50a.
- the pressing surface 64a is curved in an arc shape toward the proximal end when viewed from above.
- the pressing surface 64a is curved in an arc shape toward the proximal end so as to follow the shape of the outer periphery of the medical sheet 300.
- the pressing surface 64a extends upward and tilts toward the tip. That is, the pressing surface 64a is inclined with respect to a plane perpendicular to the axis of the second shaft 54.
- the maximum width W4 of the pressing portion 50a (width at the tip of the pressing portion 50a) is larger than the inner diameter D1 of the outer cylinder 22 (see FIG. 4).
- the pressing portion 50a has flexibility so that it can be stored within the outer cylinder 22.
- the pressing portion 50a is made of a soft resin material.
- the maximum width W4 of the pressing portion 50a is smaller than the width W1 of the intermediate support portion 38 and larger than the outer diameter of the second shaft 54.
- a supply hole 66 is opened in the pressing surface 64a for supplying liquid toward the distal end of the pressing portion 50a.
- the pressing portion 50a according to this configuration example has the same effects as the pressing portion 50 described above. That is, the maximum width W4 of the pressing portion 50a is smaller than the width of the support portion 26 (width W1 of the intermediate support portion 38) and larger than the outer diameter of the second shaft 54. Thereby, the pressing surface 64a can be made relatively wide.
- the pressing portion 50a is formed to become wider toward the distal end when viewed from above.
- the pressing surface 64a can be made wide.
- the pressing surface 64a is curved in an arc shape toward the proximal end when viewed from above.
- the outer peripheral end surface 302 of the medical sheet 300 can be reliably pressed by the pressing surface 64a.
- the pressing part 50a has flexibility.
- the maximum width W4 of the pressing portion 50a (width of the pressing surface 64a) is larger than the inner diameter D1 of the outer cylinder 22.
- the pressing surface 64a can be widened while the pressing part 50a can be stored in the outer cylinder 22.
- the pressing portion 50a may be made of a hard resin material.
- the maximum width W4 of the pressing part 50a is smaller than the inner diameter D1 of the outer cylinder 22 so that the pressing part 50a can be accommodated in the outer cylinder 22.
- the pressing portion 50a may be integrally molded with the second shaft 54.
- the supply hole 66 may not be formed in the pressing portion 50a.
- the second carrier member 20 may include a pressing portion 50b according to a second configuration example instead of the pressing portion 50 described above.
- the pressing part 50b has a connecting part 90 and a pressing body 92.
- the connecting portion 90 has the same configuration as the pressing portion 50 described above. That is, the connecting portion 90 is formed to become wider toward the distal end.
- the pressing body 92 is attached to the flat end surface of the connecting portion 90.
- the pressing body 92 is a flat plate portion extending in one direction.
- the pressing body 92 has a pressing surface 64b facing toward the tip.
- the pressing surface 64b extends upward and tilts toward the tip. That is, the pressing surface 64b is inclined with respect to a plane perpendicular to the axis of the second shaft 54.
- the pressing surface 64b is a flat surface extending along a direction (width direction) perpendicular to the axis of the second shaft 54.
- the maximum width W5 of the pressing portion 50b (width at the tip of the pressing portion 50b) is larger than the inner diameter D1 of the outer tube 22 (see FIG. 4).
- the pressing portion 50b has flexibility so that it can be stored within the outer cylinder 22.
- the pressing portion 50b is made of a soft resin material.
- a supply hole 66 is opened in the pressing surface 64b for supplying liquid toward the distal end of the pressing portion 50b.
- the pressing portion 50b according to this configuration example has the same effects as the pressing portion 50 described above.
- the pressing part 50b has flexibility.
- the maximum width W5 of the pressing portion 50b is larger than the inner diameter D1 of the outer cylinder 22.
- the pressing surface 64b can be widened while the pressing part 50b can be stored in the outer cylinder 22.
- the pressing portion 50b may be made of a hard resin material.
- the maximum width W5 of the pressing portion 50b is smaller than the inner diameter D1 of the outer cylinder 22 so that the pressing portion 50b can be accommodated within the outer cylinder 22.
- the pressing portion 50b may be integrally molded with the second shaft 54.
- the supply hole 66 may not be formed in the pressing portion 50b.
- the second carrier member 20 may include a pressing portion 50c according to a third configuration example instead of the pressing portion 50 described above.
- the pressing portion 50c is a plate-shaped portion attached to the outer peripheral surface of the tip of the second shaft 54. Specifically, the pressing portion 50c is heat-sealed to the second shaft 54. However, the pressing portion 50c may be joined to the second shaft 54 using an adhesive or the like.
- the pressing portion 50c protrudes further in the distal direction than the distal end of the second shaft 54.
- a pressing surface 64c facing toward the tip is provided at the tip of the pressing portion 50c.
- the pressing surface 64c is a flat surface.
- the maximum width W6 of the pressing portion 50c (width at the tip of the pressing portion 50c) is smaller than the inner diameter D1 of the outer tube 22 (see FIG. 4).
- the maximum width W6 is larger than the outer diameter of the second shaft 54.
- the pressing portion 50c is made of a hard resin material. However, the pressing portion 50c may be made of a soft resin material.
- the distal end of the second shaft 54 (the distal opening of the second inner cavity 57) is located above the pressing portion 50c.
- the pressing portion 50c does not have the above-mentioned supply hole 66.
- the liquid led from the second lumen 57 (liquid supply channel 68) of the second shaft 54 flows over the upper surface of the pressing portion 50c and is supplied to the medical sheet 300 located at the tip of the pressing surface 64c.
- the pressing portion 50c according to this configuration example has the same effects as the pressing portion 50c described above.
- the plate-shaped pressing portion 50c is attached to the outer circumferential surface of the tip of the second shaft 54, the configuration of the second shaft 54 can be simplified.
- the transfer instrument 10 may include an instrument main body 12b according to a second modification.
- the instrument body 12b includes a first carrier member 18, a second carrier member 20b, and an outer cylinder 22.
- the second carrier member 20b includes a second shaft 54, a pressing portion 50d, and a connector 52.
- a holding slit 112 is formed on the upper surface of the pressing portion 50d.
- the holding slit 112 extends over the entire length of the pressing portion 50d.
- the holding slit 112 is open upward.
- a holding slit 112 into which the pair of second protrusions 40 are inserted in the stored state is formed in the pressing portion 50d.
- the support portion 26 can be locked to the pressing portion 50d in the stored state. Thereby, even if the second shaft 54 is accidentally pushed in the distal direction with respect to the first shaft 24, it is possible to prevent the medical sheet 300 from protruding from the outer cylinder 22.
- the transfer device 10 may have a configuration that combines the configurations according to the first modification and the second modification as appropriate.
- Endoscope 14 may be placed in lumen 84 of outer barrel 22 . Further, the endoscope 14 may be provided separately from the instrument body 12, 12a, 12b. Note that the transfer instrument 10 does not need to include the endoscope 14.
- the above-described transfer device 10 may include a locking mechanism that limits relative movement between the first shafts 24, 24a and the second shaft 54.
- the locking mechanism can be switched between a locked state in which the relative movement of the first shafts 24, 24a and the second shaft 54 along the axial direction of the first shafts 24, 24a is restricted, and a released state in which the restriction is released.
- the first shafts 24, 24a and the second shaft 54 can be moved together with respect to the outer cylinder 22 by locking the locking mechanism in the storage process and the placement process. That is, it is possible to prevent erroneous operation of moving the second shaft 54 relative to the first shafts 24, 24a in the storage process and the placement process.
- the transfer instrument 10 may be used for laparoscopic surgery instead of thoracoscopic surgery.
- the transfer instrument 10 may also be used in open-heart surgery or open-lap surgery.
- the present embodiment is a sheet transfer method for transferring a medical sheet to a treatment target part of a living body using a transfer device, wherein the transfer device includes a first shaft and a distal end of the first shaft.
- a first carrier member including a support portion having a support surface, a second shaft extending along the axial direction of the first shaft, and a pressing portion provided at the tip of the second shaft.
- a second carrier member in the sheet transfer method, the outer peripheral end surface of the medical sheet placed on the support surface is moved by moving the second shaft in a distal direction relative to the first shaft.
- a sheet transport method in which the sheet is pressed toward the leading end by a pressing surface of the pressing section.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Surgery (AREA)
- Medical Informatics (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Radiology & Medical Imaging (AREA)
- Pathology (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP23816138.4A EP4520382A4 (en) | 2022-06-01 | 2023-06-01 | TRANSFER INSTRUMENT |
| JP2024524933A JPWO2023234381A1 (https=) | 2022-06-01 | 2023-06-01 | |
| CN202380027196.0A CN118871163A (zh) | 2022-06-01 | 2023-06-01 | 移送器具 |
| US18/962,744 US20250090293A1 (en) | 2022-06-01 | 2024-11-27 | Transfer instrument |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022-089711 | 2022-06-01 | ||
| JP2022089711 | 2022-06-01 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US18/962,744 Continuation US20250090293A1 (en) | 2022-06-01 | 2024-11-27 | Transfer instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2023234381A1 true WO2023234381A1 (ja) | 2023-12-07 |
Family
ID=89024967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP2023/020397 Ceased WO2023234381A1 (ja) | 2022-06-01 | 2023-06-01 | 移送器具 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20250090293A1 (https=) |
| EP (1) | EP4520382A4 (https=) |
| JP (1) | JPWO2023234381A1 (https=) |
| CN (1) | CN118871163A (https=) |
| WO (1) | WO2023234381A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2023234380A1 (https=) * | 2022-06-01 | 2023-12-07 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4836201A (en) * | 1988-03-24 | 1989-06-06 | Patton Medical Technologies, Inc. | "Envelope" apparatus for inserting intra-ocular lens into the eye |
| US4880000A (en) * | 1987-12-15 | 1989-11-14 | Iolab Corporation | Lens insertion instrument |
| JP2009000511A (ja) | 2007-05-22 | 2009-01-08 | Hoya Corp | 治療用物質の運搬投与器具 |
| JP2010082026A (ja) * | 2008-09-30 | 2010-04-15 | Terumo Corp | 移植用器具 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060235430A1 (en) * | 2005-04-15 | 2006-10-19 | Intralens Vision, Inc. | Corneal implant injector assembly and methods of use |
| EP1981437B1 (en) * | 2006-01-26 | 2016-05-25 | Wake Forest University Health Sciences | Corneal donor disc medical tool |
| GB201011313D0 (en) * | 2010-07-05 | 2010-08-18 | Ucl Business Plc | Implantation devices, methods and implants |
| EP4442307A4 (en) * | 2021-12-22 | 2025-03-26 | Terumo Kabushiki Kaisha | Medical device and method for applying sheet-form delivery object |
-
2023
- 2023-06-01 WO PCT/JP2023/020397 patent/WO2023234381A1/ja not_active Ceased
- 2023-06-01 EP EP23816138.4A patent/EP4520382A4/en active Pending
- 2023-06-01 JP JP2024524933A patent/JPWO2023234381A1/ja active Pending
- 2023-06-01 CN CN202380027196.0A patent/CN118871163A/zh active Pending
-
2024
- 2024-11-27 US US18/962,744 patent/US20250090293A1/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4880000A (en) * | 1987-12-15 | 1989-11-14 | Iolab Corporation | Lens insertion instrument |
| US4836201A (en) * | 1988-03-24 | 1989-06-06 | Patton Medical Technologies, Inc. | "Envelope" apparatus for inserting intra-ocular lens into the eye |
| JP2009000511A (ja) | 2007-05-22 | 2009-01-08 | Hoya Corp | 治療用物質の運搬投与器具 |
| JP2010082026A (ja) * | 2008-09-30 | 2010-04-15 | Terumo Corp | 移植用器具 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2023234381A1 (https=) | 2023-12-07 |
| CN118871163A (zh) | 2024-10-29 |
| EP4520382A1 (en) | 2025-03-12 |
| EP4520382A4 (en) | 2025-08-20 |
| US20250090293A1 (en) | 2025-03-20 |
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