WO2023217201A3 - 作为Wee1抑制剂的新型嘧啶并杂环类新化合物及其应用 - Google Patents
作为Wee1抑制剂的新型嘧啶并杂环类新化合物及其应用 Download PDFInfo
- Publication number
- WO2023217201A3 WO2023217201A3 PCT/CN2023/093349 CN2023093349W WO2023217201A3 WO 2023217201 A3 WO2023217201 A3 WO 2023217201A3 CN 2023093349 W CN2023093349 W CN 2023093349W WO 2023217201 A3 WO2023217201 A3 WO 2023217201A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- novel
- heterocyclic
- application
- pyrimido
- compound serving
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 101100102932 Xenopus laevis wee2-b gene Proteins 0.000 title 1
- 101000621390 Homo sapiens Wee1-like protein kinase Proteins 0.000 abstract 2
- 102100023037 Wee1-like protein kinase Human genes 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明公开了具有WEE1靶点抑制活性的新型嘧啶并杂环类化合物,具体公开了作为WEE1靶点抑制剂的具有式(I)结构所示化合物或其药学上可接受的盐、溶剂合物、水合物、同位素取代物或其异构体。
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210507965.4 | 2022-05-10 | ||
CN202210507965 | 2022-05-10 | ||
CN202210629355.1 | 2022-05-31 | ||
CN202210629355 | 2022-05-31 | ||
CN202210901716.3 | 2022-07-28 | ||
CN202210901716 | 2022-07-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2023217201A2 WO2023217201A2 (zh) | 2023-11-16 |
WO2023217201A3 true WO2023217201A3 (zh) | 2023-12-28 |
Family
ID=88729728
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CN2023/093349 WO2023217201A2 (zh) | 2022-05-10 | 2023-05-10 | 作为Wee1抑制剂的新型嘧啶并杂环类新化合物及其应用 |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2023217201A2 (zh) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105829315A (zh) * | 2013-12-19 | 2016-08-03 | 阿尔麦克探索有限公司 | 可用作Wee-1激酶抑制剂的嘧啶并嘧啶酮类 |
CN110603256A (zh) * | 2017-03-10 | 2019-12-20 | 阿尔麦克探索有限公司 | 可用作wee-1激酶抑制剂的嘧啶并嘧啶酮 |
WO2022136916A1 (en) * | 2020-12-22 | 2022-06-30 | Recurium Ip Holdings, Llc | Wee1 inhibitors and methods for treating cancer |
WO2023064282A1 (en) * | 2021-10-13 | 2023-04-20 | Recurium Ip Holdings, Llc | Combinations of wee 1 inhibitors and anti-cd47 antibodies. |
WO2023076485A1 (en) * | 2021-10-28 | 2023-05-04 | Recurium Ip Holdings, Llc | Combination therapies comprising wee1 inhibitors and dna damage response (ddr) inhibitors |
-
2023
- 2023-05-10 WO PCT/CN2023/093349 patent/WO2023217201A2/zh unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105829315A (zh) * | 2013-12-19 | 2016-08-03 | 阿尔麦克探索有限公司 | 可用作Wee-1激酶抑制剂的嘧啶并嘧啶酮类 |
CN110603256A (zh) * | 2017-03-10 | 2019-12-20 | 阿尔麦克探索有限公司 | 可用作wee-1激酶抑制剂的嘧啶并嘧啶酮 |
WO2022136916A1 (en) * | 2020-12-22 | 2022-06-30 | Recurium Ip Holdings, Llc | Wee1 inhibitors and methods for treating cancer |
WO2023064282A1 (en) * | 2021-10-13 | 2023-04-20 | Recurium Ip Holdings, Llc | Combinations of wee 1 inhibitors and anti-cd47 antibodies. |
WO2023076485A1 (en) * | 2021-10-28 | 2023-05-04 | Recurium Ip Holdings, Llc | Combination therapies comprising wee1 inhibitors and dna damage response (ddr) inhibitors |
Also Published As
Publication number | Publication date |
---|---|
WO2023217201A2 (zh) | 2023-11-16 |
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