WO2023211931A1 - Formulation d'augmentation de tissu non immunogène et procédé de fabrication - Google Patents

Formulation d'augmentation de tissu non immunogène et procédé de fabrication Download PDF

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Publication number
WO2023211931A1
WO2023211931A1 PCT/US2023/019806 US2023019806W WO2023211931A1 WO 2023211931 A1 WO2023211931 A1 WO 2023211931A1 US 2023019806 W US2023019806 W US 2023019806W WO 2023211931 A1 WO2023211931 A1 WO 2023211931A1
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WO
WIPO (PCT)
Prior art keywords
hydrogel composition
protein
composition according
hydrogel
methacrylated
Prior art date
Application number
PCT/US2023/019806
Other languages
English (en)
Inventor
Morteza Mahmoudi
Shahriar Sharifi
Original Assignee
Board Of Trustees Of Michigan State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Board Of Trustees Of Michigan State University filed Critical Board Of Trustees Of Michigan State University
Publication of WO2023211931A1 publication Critical patent/WO2023211931A1/fr

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52Hydrogels or hydrocolloids
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08HDERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00Macromolecular products derived from proteins
    • C08H1/02Protein-aldehyde condensates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/06Flowable or injectable implant compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/34Materials or treatment for tissue regeneration for soft tissue reconstruction
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2/00Processes of polymerisation
    • C08F2/46Polymerisation initiated by wave energy or particle radiation
    • C08F2/48Polymerisation initiated by wave energy or particle radiation by ultraviolet or visible light
    • C08F2/50Polymerisation initiated by wave energy or particle radiation by ultraviolet or visible light with sensitising agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne des compositions d'augmentation de tissu comprenant un hydrogel modifié avec de l'anhydride méthacrylique. L'hydrogel peut être composé d'albumine, de collagène, de soie ou de kératine. La composition peut être utilisée pour moduler une réponse immunitaire pour l'augmentation tissulaire et/ou en tant que charge dermique. La composition est non immunogène, non toxique et peut être utilisée pour diverses applications biomédicales, y compris des revêtements de passivation pour dispositifs biomédicaux, des dépôts et des inserts.
PCT/US2023/019806 2022-04-25 2023-04-25 Formulation d'augmentation de tissu non immunogène et procédé de fabrication WO2023211931A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263334244P 2022-04-25 2022-04-25
US63/334,244 2022-04-25

Publications (1)

Publication Number Publication Date
WO2023211931A1 true WO2023211931A1 (fr) 2023-11-02

Family

ID=88519603

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2023/019806 WO2023211931A1 (fr) 2022-04-25 2023-04-25 Formulation d'augmentation de tissu non immunogène et procédé de fabrication

Country Status (1)

Country Link
WO (1) WO2023211931A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160038636A1 (en) * 2009-07-13 2016-02-11 Nanyang Technological University Chitosan hydrogel derivatives as a coating agent with broad spectrum of antimicrobial activities
US20170232138A1 (en) * 2014-08-08 2017-08-17 The Brigham And Women's Hospital, Inc. Elastic biopolymer and use as a tissue adhesive
US20200055302A1 (en) * 2015-11-24 2020-02-20 The Texas A&M University System In Vivo Live 3D Printing of Regenerative Bone Healing Scaffolds for Rapid Fracture Healing
CN111139212A (zh) * 2019-11-26 2020-05-12 中国科学院大学温州研究院(温州生物材料与工程研究所) 一种用于细胞和组织培养的高取代白蛋白甲基丙烯酰基水凝胶的制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160038636A1 (en) * 2009-07-13 2016-02-11 Nanyang Technological University Chitosan hydrogel derivatives as a coating agent with broad spectrum of antimicrobial activities
US20170232138A1 (en) * 2014-08-08 2017-08-17 The Brigham And Women's Hospital, Inc. Elastic biopolymer and use as a tissue adhesive
US20200055302A1 (en) * 2015-11-24 2020-02-20 The Texas A&M University System In Vivo Live 3D Printing of Regenerative Bone Healing Scaffolds for Rapid Fracture Healing
CN111139212A (zh) * 2019-11-26 2020-05-12 中国科学院大学温州研究院(温州生物材料与工程研究所) 一种用于细胞和组织培养的高取代白蛋白甲基丙烯酰基水凝胶的制备方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SHARIFI SHAHRIAR, SAEI AMIR ATA, GHARIBI HASSAN, MAHMOUD NOUF N., HARKINS SHANNON, DARARATANA NARUPHORN, LISABETH ERIKA M., SERPOO: "Mass Spectrometry, Structural Analysis, and Anti-Inflammatory Properties of Photo-Cross-Linked Human Albumin Hydrogels", ACS APPLIED BIO MATERIALS, AMERICAN CHEMICAL SOCIETY, US, vol. 5, no. 6, 20 June 2022 (2022-06-20), US , pages 2643 - 2663, XP093107468, ISSN: 2576-6422, DOI: 10.1021/acsabm.2c00109 *
YOON HEEJEONG, LEE HANNA, SHIN SEON YOUNG, JODAT YASAMIN A., JHUN HYUNJHUNG, LIM WONSEOP, SEO JEONG WOOK, KIM GYUMIN, MUN JI YOUNG: "Photo-Cross-Linkable Human Albumin Colloidal Gels Facilitate In Vivo Vascular Integration for Regenerative Medicine", ACS OMEGA, ACS PUBLICATIONS, US, vol. 6, no. 49, 14 December 2021 (2021-12-14), US , pages 33511 - 33522, XP093107467, ISSN: 2470-1343, DOI: 10.1021/acsomega.1c04292 *

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