WO2023185720A1 - Composition pharmaceutique contenant un anticorps mixte anti-ctla4 et anti-pd1 et son utilisation thérapeutique - Google Patents
Composition pharmaceutique contenant un anticorps mixte anti-ctla4 et anti-pd1 et son utilisation thérapeutique Download PDFInfo
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- WO2023185720A1 WO2023185720A1 PCT/CN2023/084041 CN2023084041W WO2023185720A1 WO 2023185720 A1 WO2023185720 A1 WO 2023185720A1 CN 2023084041 W CN2023084041 W CN 2023084041W WO 2023185720 A1 WO2023185720 A1 WO 2023185720A1
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- ctla4
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
Definitions
- the host cell produces only two major antibody species, where each HC primarily pairs with its cognate LC, and most antibodies are those containing two heavy chains with the same amino acid sequence and two heavy chains with the same amino acid sequence. Tetramer of light chains (see PCT/US2017/030676).
- Partial response (PR) The sum of target lesion diameters is reduced by at least 30% from baseline.
- SAE Serious adverse events
- Blood routine no blood transfusion or correction with hematopoietic stimulating factor drugs within 14 days before obtaining the laboratory test: white blood cell count ⁇ 3.0 ⁇ 10 9 /L; absolute neutrophil count ⁇ 1.5 ⁇ 10 9 /L; platelets ⁇ 100 ⁇ 10 9 /L; hemoglobin ⁇ 90g/L;
- ZPML265 single agent combined with chemotherapy was used to treat 40 patients with extensive-stage small cell lung cancer.
- the efficacy analysis was based on 39 evaluable patients. As of January 16, 2023, the confirmed ORR was 89.7% (35/39) and 35 patients (92.1%).
- the best overall tumor assessment of the subjects was PR, 3 subjects (7.7%) subjects had the best overall tumor assessment of SD, 1 subject (2.6%) was PD, the overall DCR was 97.4% (38/39), 3 subjects
- the monthly PFS rate was 94.8%, and the median PFS was 5.7 months (95% confidence interval: 5.4-7.1 months).
Abstract
L'invention concerne une utilisation d'un agent de chimiothérapie combiné contenant un anticorps mixte anti-CTLA4 et anti-PD1, par exemple, carboplatine/cisplatine et étoposide, dans le traitement du cancer du poumon à petites cellules.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210315191.5 | 2022-03-28 | ||
CN202210315191 | 2022-03-28 |
Publications (1)
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US20190218292A1 (en) * | 2016-05-31 | 2019-07-18 | Laboratoire Français du Fractionnement et des Biot Echnologies | Antibody for cancer treatment |
CN110312523A (zh) * | 2016-11-08 | 2019-10-08 | 齐鲁皮吉特湾生物治疗有限公司 | 抗pd1和抗ctla4抗体 |
CN110505882A (zh) * | 2017-03-31 | 2019-11-26 | 默沙东公司 | 用pd-1的拮抗剂和抗ctla4抗体的组合治疗癌症的组合物和方法 |
CN110536905A (zh) * | 2017-02-21 | 2019-12-03 | 瑞泽恩制药公司 | 用于治疗肺癌的抗pd-1抗体 |
US20210070863A1 (en) * | 2019-09-05 | 2021-03-11 | Astrazeneca Ab | Compositions and methods for treating late stage lung cancer |
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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US20190218292A1 (en) * | 2016-05-31 | 2019-07-18 | Laboratoire Français du Fractionnement et des Biot Echnologies | Antibody for cancer treatment |
CN110312523A (zh) * | 2016-11-08 | 2019-10-08 | 齐鲁皮吉特湾生物治疗有限公司 | 抗pd1和抗ctla4抗体 |
CN110536905A (zh) * | 2017-02-21 | 2019-12-03 | 瑞泽恩制药公司 | 用于治疗肺癌的抗pd-1抗体 |
CN110505882A (zh) * | 2017-03-31 | 2019-11-26 | 默沙东公司 | 用pd-1的拮抗剂和抗ctla4抗体的组合治疗癌症的组合物和方法 |
US20210070863A1 (en) * | 2019-09-05 | 2021-03-11 | Astrazeneca Ab | Compositions and methods for treating late stage lung cancer |
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