WO2023174402A1

WO2023174402A1 - Tissue containing transferable hyaluronic acid salt and finishing solution composition

Info

Publication number: WO2023174402A1
Application number: PCT/CN2023/082168
Authority: WO
Inventors: 刘喆; 杨娟
Original assignee: 华熙生物科技股份有限公司
Priority date: 2022-03-18
Filing date: 2023-03-17
Publication date: 2023-09-21
Also published as: CN114712262A

Abstract

A tissue containing hyaluronic acid or a salt thereof, and a composition comprising hyaluronic acid or a salt thereof and a hydrophobic substance. The transferability of the hyaluronic acid when wiping with the tissue can be improved by means of combining the hydrophobic substance with the hyaluronic acid or the salt thereof.

Description

A kind of paper towel and finishing liquid composition containing migratory hyaluronic acid salt

Technical field

The present invention relates to the technical field of paper product preparation, and in particular to a paper towel and finishing liquid composition containing migratory hyaluronic acid salt.

Background technique

Sodium hyaluronate (HA, also known as hyaluronic acid, or hyaluronic acid) is a natural moisturizing ingredient that has been widely used in pharmaceuticals and personal health consumer products. In recent years, hyaluronic acid tissues have appeared in the consumer goods market, with the intention of adding HA to improve the skin care properties of the tissues.

However, due to the presence of a large number of hydroxyl and carboxyl groups in the HA molecule, HA can form strong hydrogen bonds with the cellulose of the tissue. Therefore, during the friction between the tissue and the skin, HA is difficult to migrate from the surface of the tissue to the surface of the skin, making it difficult to achieve the skin care effect of HA.

Contents of the invention

In order to solve the above problems, the present invention provides a finishing liquid composition and paper towels containing hyaluronic acid or its salt. The finishing liquid composition can significantly increase HA by combining a hydrophobic substance with HA and adding it to the surface of the paper towel. Migration during tissue rubbing.

The specific technical solutions of the present invention are as follows:

1. A finishing liquid composition containing hyaluronic acid or a salt thereof and a hydrophobic substance.

2. The composition according to item 1, wherein the hydrophobic substance is a grease or wax. Preferably, the grease or wax is a hydrocarbon substance or a mixture of a hydrocarbon substance and a non-hydrocarbon substance;

Or; the hydrophobic substance includes hydrocarbon substances.

3. The composition according to item 2, wherein the carbon number of the hydrocarbon material is 10-60, preferably 28-52, and further preferably, the hydrocarbon material is squalane, mineral oil and / or petrolatum, preferably petrolatum.

4. The composition according to item 2 or 3, wherein the non-hydrocarbon substance is a non-hydrocarbon substance of plant origin, animal origin and/or artificial synthesis. Preferably, the non-hydrocarbon substance is selected from glycerol. One or more of triester, diglyceride, monoglyceride, ester wax and silicone oil.

5. The composition according to any one of items 1 to 4, wherein the molecular weight of the hyaluronic acid or its salt is 1w-150wDa, preferably 20w-80wDa.

6. The composition according to any one of items 1 to 4, wherein the hyaluronic acid or a salt thereof is cross-linked hyaluronic acid or a salt thereof.

7. The composition according to any one of items 1 to 6, wherein the finishing liquid composition further includes an emulsifier. Preferably, the emulsifier is a nonionic or anionic surfactant. Preferably, the emulsifier is The nonionic surfactant is selected from the group consisting of Tween-20, Tween-80, Cetearyl-6, Cetearyl-25, Cetearyl Olive Acid and Sorbitan One or more than two kinds of olive oil esters. Preferably, the anionic surfactant is selected from sodium stearyl glutamate, sodium laurate, sodium dodecyl benzene sulfonate, and dodecyl sulfate. One or more of sodium and sodium oleate.

8. The composition according to any one of items 1 to 7, wherein the hyaluronic acid or its salt is 0.01-0.5%, preferably 0.1-0.2, based on the mass percentage in the composition. %;

Preferably, the hydrophobic substance is 0.5-25%, more preferably 5-20%.

9. The composition according to any one of items 1-8, wherein the composition further comprises glycerol and water-soluble active ingredients. Preferably, the water-soluble active ingredients include ectoine and ergothioneine. , γ-aminobutyric acid, one or more of amino acids and proteins.

10. Use of the composition described in any one of items 1-9 in paper products.

11. A tissue containing a composition of hyaluronic acid or a salt thereof and a hydrophobic substance.

12. The paper towel according to item 11, wherein the hydrophobic substance is grease or wax. Preferably, the grease or wax is a hydrocarbon substance or a mixture of a hydrocarbon substance and a non-hydrocarbon substance;

Or; the hydrophobic substance includes hydrocarbon substances.

13. The paper towel according to item 12, wherein the carbon number of the hydrocarbon material is 10-60, preferably 28-52, and further preferably, the hydrocarbon material is squalane, mineral oil and/or Or petrolatum, preferably petrolatum.

14. The paper towel according to item 12 or 13, wherein the non-hydrocarbon substance is a non-hydrocarbon substance of plant origin, animal origin and/or artificial synthesis. Preferably, the non-hydrocarbon substance is selected from triglycerides. One or more of ester, diglyceride, monoglyceride, ester wax and silicone oil.

15. The paper towel according to any one of items 11 to 14, wherein the molecular weight of the hyaluronic acid or its salt is 1w-150wDa, preferably 20w-80wDa.

16. The paper towel according to any one of items 11 to 14, wherein the hyaluronic acid or a salt thereof is cross-linked hyaluronic acid or a salt thereof.

17. The paper towel according to any one of items 11-16, wherein the composition further comprises an emulsifier. Preferably, the emulsifier is a nonionic or anionic surfactant. Preferably, the nonionic The surfactant is selected from Tween-20, Tween-80, Cetearyl-6, Cetearyl-25, Cetearyl Olive Acid and Sorbitan Olive Acid One or more than two esters, preferably, the anionic surfactant is selected from the group consisting of sodium stearyl glutamate, sodium laurate, sodium dodecyl benzene sulfonate, sodium lauryl sulfate and oil. One or more than two kinds of sodium acid.

18. The paper towel according to any one of items 11 to 17, wherein the content of the hyaluronic acid or its salt in the paper towel is 5-5000 ppm, preferably 300-900 ppm, and further preferably 300-500 ppm.

19. The paper towel according to any one of items 11-18, wherein the content of the hydrophobic substance in the paper towel is 0.1-6%, preferably 2-5%.

20. The paper towel according to any one of items 11 to 19, wherein the composition containing hyaluronic acid or a salt thereof and a hydrophobic substance further contains glycerin and a water-soluble active ingredient. Preferably, the water-soluble The active ingredients include one or more of ectoine, ergothioneine, γ-aminobutyric acid, amino acids and proteins.

21. The paper towel according to any one of items 11 to 20, wherein the mobility of the hyaluronic acid or its salt is ≥1%, preferably ≥5%.

22. The paper towel according to any one of items 11-21, wherein the paper towel contains cellulose fiber, preferably, the content of the cellulose fiber is ≥50%.

22. The use of hydrophobic substances to improve the mobility of hyaluronic acid during rubbing with paper towels.

23. The use according to item 21, the hydrophobic substance is grease or wax. Preferably, the grease or wax is a hydrocarbon substance or a mixture of hydrocarbon substances and non-hydrocarbon substances;

Or; the hydrophobic substance includes hydrocarbon substances;

Preferably, the carbon number of the hydrocarbon material is 10-60, preferably 28-52;

Further preferably, the hydrocarbon material is squalane, mineral oil and/or petrolatum, preferably petrolatum.

Effect of the invention

The finishing fluid composition of the present invention can significantly improve the migration of HA during the rubbing process of paper towels by combining a hydrophobic substance with HA and coating it on paper towels.

Description of the drawings

Figure 1 is a flow chart for coating.

Figure 2 is a flow chart for measuring HA in imitation leather. Figure 2A is a schematic diagram of fixing paper towels on a square weight block, and Figure 2B is a schematic diagram of the friction migration test method.

Among them, 1-paper towel base material, 2-first guide roller, 3-second guide roller, 4-third guide roller, 5-fourth guide roller, 6-squeeze roller, 7-transfer roller, 8-impregnation Roller, 9-trough, 10-fifth guide roller, 11-paper towel after coating

Detailed ways

The present invention will be described in detail below with reference to the embodiments described in the accompanying drawings, where the same numerals in all the drawings represent the same features. Although specific embodiments of the invention are shown in the drawings, it should be understood that the invention may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided to provide a thorough understanding of the invention, and to fully convey the scope of the invention to those skilled in the art.

It should be noted that certain words are used in the description and claims to refer to specific components. Those skilled in the art will understand that skilled persons may use different names to refer to the same component. This description and the claims do not use difference in nouns as a way to distinguish components, but rather use differences in functions of the components as a criterion for distinction. If the words "include" or "including" mentioned throughout the description and claims are open-ended terms, they should be interpreted as "including but not limited to." The following descriptions of the description are preferred embodiments for implementing the present invention. However, the descriptions are for the purpose of general principles of the description and are not intended to limit the scope of the present invention. The protection scope of the present invention shall be determined by the appended claims.

The present invention provides a tissue containing a composition of hyaluronic acid or a salt thereof and a hydrophobic substance.

Hyaluronic acid is added to existing paper towels to improve the skin care properties of the paper towels. However, due to the large number of hydroxyl and carboxyl groups in the hyaluronic acid molecules, hyaluronic acid can form strong hydrogen bonds with the cellulose of the paper towels. Therefore, during the friction between the paper towel and the skin, it is difficult for hyaluronic acid to migrate from the surface of the paper towel to the surface of the skin, making it difficult to achieve the skin care effect of hyaluronic acid. The present invention adds hyaluronic acid and hydrophobic substances to the paper towel. In the composition, the hydrophobic substance significantly improves the mobility of hyaluronic acid during tissue friction by reducing the hydrogen bond between hyaluronic acid and tissue fibers. The mobility of hyaluronic acid in tissue is above 1%, preferably in More than 5%.

In some embodiments, the hydrophobic substance is a grease or wax. Preferably, the grease or wax is a hydrocarbon substance or a mixture of a hydrocarbon substance and a non-hydrocarbon substance. Preferably, the carbon content of the hydrocarbon substance is The number of atoms is 10-60, preferably 28-52. Further preferably, the hydrocarbon material is squalane, mineral oil and/or petrolatum, preferably petrolatum; preferably, the non-hydrocarbon material is Plant sources, animals Source and/or artificially synthesized non-hydrocarbon substances. Preferably, the non-hydrocarbon substances are selected from one or two or more types of triglycerides, diglycerides, monoglycerides, ester waxes and silicone oils.

The ester wax refers to an ester formed from long-chain higher fatty acids and higher fatty alcohols, which can include naturally occurring and artificially synthesized ones. For example, the main components of jojoba oil and jojoba ester are naturally occurring ester waxes. .

The hydrocarbon substances refer to chemical substances consisting only of carbon and hydrogen elements, which appear in the form of liquid or semi-solid wax at normal temperature; the non-hydrocarbon substances also appear in the form of liquid or semi-solid wax at normal temperature, and The molecular structure contains elements other than carbon and hydrogen, such as oxygen, silicon, sulfur, etc., such as triglycerides, diglycerides, monoglycerides, ester waxes, silicone oils, and mixtures thereof.

For example, the number of carbon atoms of the hydrocarbon material is 10, 20, 30, 40, 50, 60 or any natural number therebetween.

Squalane has a carbon number of 30, mineral oil has a carbon number of 12-24, and petrolatum has a carbon number of 28-52.

In some embodiments, the hydrophobic substance includes a hydrocarbon substance. Preferably, the number of carbon atoms of the hydrocarbon substance is 10-60, preferably 28-52. More preferably, the hydrocarbon substance is Squalane, mineral oil and/or petrolatum, preferably petrolatum.

The present invention uses the above-mentioned hydrophobic substance, mixes it with hyaluronic acid and an emulsifier, and coats it on the surface of paper towels, which can provide mobility of hyaluronic acid during the rubbing process of paper towels.

In some embodiments, the molecular weight of the hyaluronic acid or salt thereof is 1w-150wDa, preferably 20w-80wDa.

In some embodiments, the hyaluronic acid or salt thereof is cross-linked hyaluronic acid or salt thereof.

The cross-linked hyaluronic acid or its salt refers to a derivative of hyaluronic acid or its salt after chemical modification. After modification by a cross-linking agent, linear hyaluronic acid molecules are connected into a spatial network structure. .

The salt of hyaluronic acid refers to a metal salt of hyaluronic acid, which may be sodium hyaluronate, magnesium hyaluronate, zinc hyaluronate, etc., and is preferably sodium hyaluronate.

For example, the molecular weight of the hyaluronic acid or its salt may be 1wDa, 5wDa, 10wDa, 20wDa, 30wDa, 40wDa, 50wDa, 60wDa, 70wDa, 80wDa, 90wDa, 100wDa, 110wDa, 120wDa, 130wDa, 140wDa, 150wDa, etc.

In some embodiments, the mass ratio of the hyaluronic acid or its salt to the hydrophobic substance is 1:4-150, preferably 1:10-150.

For example, the mass ratio of the hyaluronic acid or its salt to the hydrophobic substance (m _{hyaluronic acid or its salt} : m _{hydrophobic _substance} ) can be 1:4, 1:4.6, 1:10, 1:15, 1:20, 1:25, 1:30, 1:40, 1:50, 1:60, 1:70, 1:80, 1:90, 1:100, 1:110, 1:120, 1: 130, 1:140, 1:150, etc.

In some embodiments, the composition further includes an emulsifier. Preferably, the emulsifier is a nonionic or anionic surfactant. Preferably, the nonionic surfactant is selected from Tween-20, Tween -80, one or more of cetearyl ether-6, cetearyl ether-25, cetearyl olivate and sorbitan olive ester, preferably , the anionic surfactant is selected from one or two or more types of sodium laurate, sodium dodecyl benzene sulfonate, sodium lauryl sulfate and sodium oleate.

In some embodiments, the content of the hyaluronic acid or its salt in the paper towel is 5-5000 ppm, preferably 300-900 ppm, and further preferably 300-500 ppm.

For the determination of the content of hyaluronic acid or its salt in paper towels, it can be determined according to the method disclosed in CN109298112A.

For example, the content of the hyaluronic acid or its salt in the paper towel can be 5ppm, 10ppm, 20ppm, 30ppm, 40ppm, 50ppm, 100ppm, 200ppm, 300ppm, 400ppm, 500ppm, 600ppm, 700ppm, 800ppm, 900ppm, 1000ppm, 2000ppm , 3000ppm, 4000ppm, 5000ppm, etc.

In some embodiments, the content of the hydrophobic material in the tissue is 0.1-6%, preferably 2-5%.

For the determination of the content of the hydrophobic substance in the paper towel, it can be determined according to the national standard measurement method GB/T 6504 for the oil content of chemical fibers. However, in this method, the operation of the fiber becomes the operation of the paper towel: you can first Use organic solvents, such as isopropyl alcohol or acetone, to extract hydrophobic substances on paper towels, and then measure the extract using liquid chromatography coupled with mass spectrometry.

For example, the content of the hydrophobic substance in the paper towel can be 0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, etc.

The present invention does not impose any restrictions on the content of the emulsifier in the paper towel. Those skilled in the art can select it according to needs. For example, the content of the emulsifier in the paper towel can be 0.2-2%.

For example, the content of emulsifier in the paper towel can be 0.2%, 0.5%, 0.8%, 1%, 1.5%, 2%, etc.

In some embodiments, the composition containing hyaluronic acid or a salt thereof and a hydrophobic substance further contains glycerol.

The present invention does not impose any restrictions on the content of glycerol in the paper towel, which can be selected according to needs. For example, the content of glycerin in the paper towel can be 0.1-20%.

For example, the content of glycerol in paper towels can be 0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12 %, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, etc.

The glycerin can improve the softness and feel of paper towels.

In some embodiments, the composition containing hyaluronic acid or a salt thereof and a hydrophobic substance also contains a water-soluble active ingredient. Preferably, the water-soluble active ingredient includes ectoine, ergothioneine, γ- One or more of aminobutyric acid, amino acids and protein.

The present invention does not impose any restrictions on the content of water-soluble active ingredients in paper towels, which can be selected as needed.

The water-soluble active ingredients can increase the skin care properties of the tissue.

In some embodiments, the hyaluronic acid or salt thereof has a mobility of ≥1%, preferably ≥5%.

The migration rate refers to the efficiency of HA migration to imitation leather during the friction test. Its calculation formula is as follows:
Migration rate = the amount of HA on the imitation leather after rubbing/the HA content of the paper towel on the contact surface of the cube before rubbing.

In some embodiments, the paper towel contains cellulose fibers. Preferably, the content of the cellulose fibers is ≥50%.

The paper towel refers to a paper towel base material, for example, a medium smooth, clean and soft paper towel base material can be used.

In some embodiments, the tissue includes a composition containing hyaluronic acid or a salt thereof and a hydrophobic substance. In some embodiments, the hydrophobic substance is a grease or wax. Preferably, the grease or wax is a hydrocarbon substance or a mixture of a hydrocarbon substance and a non-hydrocarbon substance. Alternatively, in some embodiments, the hydrophobic material includes hydrocarbon material.

In some embodiments, the tissue includes a composition containing hyaluronic acid or a salt thereof and a hydrophobic substance. In some embodiments, the hydrophobic substance is grease or wax. Preferably, the grease is a hydrocarbon substance or a mixture of hydrocarbon substances and non-hydrocarbon substances. Alternatively, in some embodiments, the hydrophobic material includes hydrocarbon material. In some embodiments, the number of carbon atoms of the hydrocarbon material is 10-60, preferably 28-52, and further preferably, the hydrocarbon material is squalane, mineral oil and/or petrolatum, preferably Petrolatum.

In some embodiments, the tissue includes a composition containing hyaluronic acid or a salt thereof and a hydrophobic substance. In some embodiments, the hydrophobic substance is grease or wax. Preferably, the oil Grease or wax is a hydrocarbon substance or a mixture of hydrocarbon substances and non-hydrocarbon substances. Alternatively, in some embodiments, the hydrophobic material includes hydrocarbon material. In some embodiments, the number of carbon atoms of the hydrocarbon material is 10-60, preferably 28-52, and further preferably, the hydrocarbon material is squalane, mineral oil and/or petrolatum, preferably Petrolatum. In some embodiments, the non-hydrocarbon substances are plant-derived, animal-derived and/or synthetic non-hydrocarbon substances. Preferably, the non-hydrocarbon substances are selected from the group consisting of triglycerides, diglycerides, and monoglycerides. One or more of ester, ester wax and silicone oil.

In some embodiments, the tissue includes a composition containing hyaluronic acid or a salt thereof and a hydrophobic substance. In some embodiments, the hydrophobic substance is a grease or wax. Preferably, the grease or wax is a hydrocarbon substance or a mixture of a hydrocarbon substance and a non-hydrocarbon substance. Alternatively, in some embodiments, the hydrophobic material includes hydrocarbon material. In some embodiments, the number of carbon atoms of the hydrocarbon material is 10-60, preferably 28-52, and further preferably, the hydrocarbon material is squalane, mineral oil and/or petrolatum, preferably Petrolatum. In some embodiments, the non-hydrocarbon substances are plant-derived, animal-derived and/or synthetic non-hydrocarbon substances. Preferably, the non-hydrocarbon substances are selected from the group consisting of triglycerides, diglycerides, and monoglycerides. One or more of ester, ester wax and silicone oil. In some embodiments, the molecular weight of the hyaluronic acid or salt thereof is 1w-150wDa, preferably 20w-80wDa. Or in some embodiments, the hyaluronic acid or salt thereof is cross-linked hyaluronic acid or salt thereof. In some embodiments, the composition further includes an emulsifier. Preferably, the emulsifier is a nonionic or anionic surfactant. Preferably, the nonionic surfactant is selected from Tween-20, Tween -80, one or more of cetearyl ether-6, cetearyl ether-25, cetearyl olivate and sorbitan olive ester, preferably , the anionic surfactant is selected from one or more than two kinds of sodium stearoyl glutamate, sodium laurate, sodium dodecyl benzene sulfonate, sodium lauryl sulfate and sodium oleate. In some embodiments, the content of the hyaluronic acid or its salt in the finishing liquid is 0.01-0.5%, preferably 0.1-0.2%. In some embodiments, the content of the hydrophobic substance in the finishing liquid is 0.5-25%, preferably 5-20%. In some embodiments, the content of the hyaluronic acid or its salt in the paper towel is 5-5000 ppm, preferably 300-900 ppm, and further preferably 300-500 ppm. In some embodiments, the content of the hydrophobic material in the tissue is 0.1-6%, preferably 2-5%. In some embodiments, the composition containing hyaluronic acid or a salt thereof and a hydrophobic substance further contains glycerin. In some embodiments, the composition containing hyaluronic acid or a salt thereof and a hydrophobic substance also contains a water-soluble active ingredient. Preferably, the water-soluble active ingredient includes ectoine, ergothioneine, γ- One or more of aminobutyric acid, amino acids and protein. In some embodiments, the hyaluronic acid or salt thereof The mobility is ≥1%, preferably ≥5%. In some embodiments, the mass ratio of the hyaluronic acid or salt thereof to the hydrophobic substance is 1:4-150, preferably 1:10-150.

The present invention provides a finishing liquid composition containing hyaluronic acid or a salt thereof and a hydrophobic substance.

In some embodiments, the hydrophobic substance is a grease or wax. Preferably, the grease or wax is a hydrocarbon substance or a mixture of a hydrocarbon substance and a non-hydrocarbon substance. Alternatively, in some embodiments, the hydrophobic material includes hydrocarbon material. In some embodiments, the number of carbon atoms of the hydrocarbon material is 10-60, preferably 28-52, and further preferably, the hydrocarbon material is squalane, mineral oil and/or petrolatum, preferably Petrolatum. In some embodiments, the non-hydrocarbon substances are plant-derived, animal-derived and/or synthetic non-hydrocarbon substances. Preferably, the non-hydrocarbon substances are selected from the group consisting of triglycerides, diglycerides, and monoglycerides. One or more of ester, ester wax and silicone oil.

In some embodiments, the hydrophobic substance includes a hydrocarbon substance. Preferably, the number of carbon atoms of the hydrocarbon substance is 10-60, preferably 28-52. More preferably, the hydrocarbon substance The substances are squalane, mineral oil and/or petrolatum, preferably petrolatum.

For example, the salt of hyaluronic acid refers to a metal salt of hyaluronic acid, such as sodium hyaluronate, magnesium hyaluronate, zinc hyaluronate, etc., and is preferably sodium hyaluronate.

In some embodiments, the mass ratio of the hyaluronic acid or its salt to the hydrophobic substance is 1:5-150, preferably 1:10-150.

For example, the mass ratio of the hyaluronic acid or its salt and the hydrophobic substance can be (m _{hyaluronic acid or its salt} : m _{hydrophobic substance} ) and can be 1:5, 1:10, 1:15, 1:20 , 1:25, 1:30, 1:40, 1:50, 1:60, 1:70, 1:80, 1:90, 1:100, 1:110, 1:120, 1:130, 1 :140, 1:150, etc.

In some embodiments, the finishing fluid composition further includes an emulsifier. Preferably, the emulsifier is a nonionic or anionic surfactant. Preferably, the nonionic surfactant is selected from Tween-20, Tween-80, Cetearyl-6, Cetearyl-25, Cetearyl Olive One or more of oleic acid ester and sorbitan olive acid ester. Preferably, the anionic surfactant is selected from the group consisting of sodium stearyl glutamate, sodium laurate, and sodium dodecyl benzene sulfonate. , one or more of sodium lauryl sulfate and sodium oleate.

In some embodiments, the hyaluronic acid or its salt is 0.01-0.5%, preferably 0.1-0.2%, based on the mass percentage in the composition;

Preferably, the hydrophobic substance is 0.5-25%, more preferably 5-20%.

For example, based on the mass percentage in the composition, the hyaluronic acid or its salt may be 0.01%, 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5% or anything in between. scope;

The hydrophobic substance can be 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 23%, 24%, 25 % or any range in between.

The present invention does not impose any restrictions on the content of the emulsifier in the composition. Those skilled in the art can select it according to needs. For example, the content of the emulsifier in the composition can be 0.5-10%.

For example, the emulsifier may be present in the composition at 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, etc.

The present invention does not impose any restrictions on the content of glycerin in the composition, which can be selected according to needs. For example, the content of glycerol in the composition can be 0.1-80%.

For example, the content of glycerin in the composition may be 0.1%, 0.5%, 1%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, etc.

In some embodiments, the finishing fluid composition includes hyaluronic acid or a salt thereof and a hydrophobic substance. In some embodiments, the hydrophobic substance is a grease or wax. Preferably, the grease or wax is a hydrocarbon substance or a mixture of a hydrocarbon substance and a non-hydrocarbon substance. Alternatively, in some embodiments, the hydrophobic material includes hydrocarbon material. In some embodiments, the molecular weight of the hyaluronic acid or salt thereof is 1w-150wDa, preferably 20w-80wDa. Or in some embodiments, the hyaluronic acid or salt thereof is cross-linked hyaluronic acid or salt thereof. In some embodiments, the hyaline The mass ratio of the acid or its salt to the hydrophobic substance is 1:5-150, preferably 1:10-150. In some embodiments, the finishing fluid composition further includes an emulsifier. Preferably, the emulsifier is a nonionic or anionic surfactant. Preferably, the nonionic surfactant is selected from Tween-20, One or more of Tween-80, Cetearyl-6, Cetearyl-25, Cetearyl Olivate and Sorbitan Olivate, Preferably, the anionic surfactant is selected from one or more of sodium stearoyl glutamate, sodium laurate, sodium dodecyl benzene sulfonate, sodium lauryl sulfate and sodium oleate. . In some embodiments, the hyaluronic acid or its salt is 0.01-0.5%, preferably 0.1-0.2%, based on the mass percentage in the composition; preferably, the hydrophobic substance is 0.5-0.5%. 25%, more preferably 5-20%. In some embodiments, the mass ratio of the hyaluronic acid or its salt to the hydrophobic substance is 1:5-150, preferably 1:10-150.

The preparation method of the finishing fluid composition of the present application is not particularly limited and can be prepared according to conventional methods in the art. For example, it can be prepared by the following preparation method:

(1) Premix HA powder and glycerol to form suspension RM-1;

(2) Add emulsifier to water and dissolve to obtain RM-2;

(3) Add hydrophobic substances to RM-2 and stir to form emulsion RM-3;

(4) Add RM-1 to RM-3 and mix homogeneously to form a finishing liquid composition;

In step (2), add the emulsifier to water, heat to 60°C, and stir until a transparent and clear solution RM-2 is obtained;

In step (3), slowly add the hydrophobic substance to RM-2 for stirring, and control the system temperature to 60°C to form emulsion RM-3;

In step (4), add RM-1 to RM-3, control the system temperature to 60°C, and mix homogeneously for 30 minutes.

In the present invention, the finishing liquid composition is coated on the paper towel. The hydrophobic substance can reduce the hydrogen bond between hyaluronic acid and the cellulose of the paper towel, thereby significantly improving the mobility of hyaluronic acid during the rubbing process of the paper towel. The mobility is above 1%, preferably above 5%, and further preferably above 10%, indicating that coating the finishing fluid composition of the present invention on paper towels can significantly improve the mobility of hyaluronic acid.

The present invention does not impose any restrictions on the coating method. Those skilled in the art can choose according to needs. For example, the roller coating method can be used for coating. For example, the finishing liquid is placed in a trough, where the trough has a heating function. Control the temperature of the finishing liquid at 60-80°C, and the dipping roller is partially immersed in the finishing liquid in the trough, and rotates clockwise to bring up the finishing liquid;

The transfer roller rotates counterclockwise, and through contact with the dipping roller, the finishing liquid is evenly spread on the surface of the transfer roller; the paper towel base material passes between the squeeze roller and the transfer roller, where the transfer roller rotates counterclockwise, and the squeeze roller The hour hand rotates to evenly apply the finishing liquid on the surface of the paper towel.

The present invention does not impose any restrictions on the coating amount applied to paper towels. Those skilled in the art can choose according to needs. In the present invention, the coating amount used is 30%, and its calculation formula is W2-W1/W1. *100%. Among them, W1 is the original mass of the paper towel base material, and W2 is the total water content of the paper towel after coating.

This application provides the use of the composition described above in paper products.

The present application provides the use of hydrophobic substances in improving the mobility of hyaluronic acid during rubbing with paper towels. In some embodiments, the hydrophobic substance is a grease or wax. Preferably, the grease or wax is a hydrocarbon substance or a mixture of a hydrocarbon substance and a non-hydrocarbon substance; or in some embodiments, the hydrophobic substance is Sexual substances include hydrocarbons. Preferably, the carbon number of the hydrocarbon material is 10-60, preferably 28-52; further preferably, the hydrocarbon material is squalane, mineral oil and/or petrolatum, preferably petrolatum.

Example

The present invention provides a general and/or specific description of the materials and test methods used in the test. In the following examples, if there are no other special instructions, % means wt%, that is, weight percentage. If the manufacturer of the reagents or instruments used is not indicated, they are all conventional reagent products that are commercially available. The sources of raw materials described in the examples and comparative examples are shown in Table 1.

Table 1 Raw material sources

Among them, octanoic acid glyceryl is a triglyceride with a carbon number of 21, coconut oil is a triglyceride with a carbon number of 39, palm oil is a triglyceride with a carbon number of 51, and ethyl caprylate is a glycerol monomer. Esters have 10 carbon atoms, isooctyl palmitate is a glyceryl monoester with a carbon number of 24, and jojoba oil is a glyceryl monoester with a carbon number of 38-44.

Example 1

(1) Premix HA powder and glycerol to form suspension RM-1;

(2) Add the emulsifier to the water, heat to 60°C and stir until a transparent and clear solution RM-2 is obtained;

(3) Slowly add hydrophobic substances into RM-2 and stir, and control the system temperature to 60°C to form emulsion RM-3;

(4) Add RM-1 to RM-3, control the system temperature to 60°C, and mix homogeneously for 30 minutes to form the final finishing liquid, in which the contents of various components are as follows: C1-C22 and C25 in Table 2 As shown, the balance is water.

Comparative example 1

Preparation was carried out in the same manner as in Example 1, and the contents of various components are shown in Table 2 as numbers C23-C24.

Table 2 Contents of various components

Example 2 Preparation of paper towels

As shown in Figure 1, the finishing liquid obtained in Example 1 is placed in the trough 9. The dipping roller 8 is partially immersed in the finishing liquid in the trough 9 to maintain the temperature at 60-80°C. By rotating clockwise, The finishing liquid is brought up, the transfer roller 7 rotates counterclockwise, and through contact with the dipping roller 8, the finishing liquid is evenly spread on the surface of the transfer roller 7, and the paper towel base material 1 passes through the first guide roller 2 and the second guide roller 3 is in contact with the squeeze roller 6 to coat the finishing liquid on the tissue base material. The coating amount is 30%. The calculation formula for the coating amount is: W2–W1/W1*100%, where W1 is the tissue base material. The original mass of the paper towel, W2 is the total water content of the paper towel after coating. The numbers of the paper towels obtained are Nap1-Nap22 and Nap25. The contents of each component are shown in Table 3.

Among them, the measurement method of HA is measured according to the method disclosed in CN109298112A;

The determination method of hydrophobic substances follows the national standard measurement method GB/T 6504 for the oil content of chemical fibers, but in this method, the operation of the fiber becomes the operation of the paper towel: you can first use an organic solvent, such as isopropyl alcohol or Acetone is used to extract hydrophobic substances on paper towels, and then the extract is measured using liquid chromatography coupled with mass spectrometry;

The contents of emulsifier and glycerol can be measured according to conventional methods in the art.

Comparative example 2

The finishing liquid composition described in Comparative Example 1 was used for coating in the same method as Example 2 to obtain paper towels, which were numbered Nap23-Nap24. The contents of each component are as shown in Table 3.

Table 3 Contents of different components in paper towels

Experimental Example 1 Measurement of Mobility of Hyaluronic Acid

Experimental materials: silicone imitation leather with a size of 5cm×12cm, a cube with a mass of 300g and a size of 5cm×5cm, a tensile gauge with a range of 5N and a rubber band.

How to operate:

1) After cleaning the imitation leather surface with deionized water, dry the surface moisture at room temperature;

2) Use an analytical balance to accurately record the quality of imitation leather;

3) Use a sprayer to evenly spray 0.1g deionized water on the surface of the imitation leather;

4) Wipe the experimental tabletop with alcohol, and fix the 5cm×12cm silicone imitation leather on the smooth horizontal tabletop;

5) Fix the paper towels numbered Nap1-Nap24 on one side of the cube weight block, and place the side with the paper towel directly above the imitation leather. The center of gravity of the cube weight block is vertically aligned with one end of the imitation leather, and the sides of the weight are aligned with Align the edges of the imitation leather, as shown in Figure 2A and Figure 2B;

6) Use a force gauge to drag the weight horizontally and at a constant speed until the center of gravity of the weight reaches the end of the imitation leather. Repeat this 5 times;

7) Cut the imitation leather into small pieces, place it in a narrow-mouth glass bottle, and detect the HA content in the imitation leather;

8) Calculate the migration rate of HA from paper towels to imitation leather. The results are shown in Table 4. The calculation formula for the migration rate is:
Migration rate=Amount of HA in imitation leather after friction test/Amount of HA on the contact area of the cube before friction test
HA content

The detection method of HA content in imitation leather is as follows:

(1) Reagents and materials:

Sodium dihydrogen phosphate (Sinopharm Group Chemical Reagent Co., Ltd.), disodium hydrogen phosphate (Sinopharm Group Chemical Reagent Co., Ltd.), phosphoric acid (Sinopharm Group Chemical Reagent Co., Ltd.), hyaluronic acid reference substance (Bloomage Biotechnology Co., Ltd. Co., Ltd.) and hyaluronidase (Bloomage Biotechnology Co., Ltd.)

(2) Chromatographic conditions

Chromatographic column: MCI GEL CK08EH column (8×300mm, 9μm), mobile phase: 1% phosphoric acid; flow rate: 0.6ml/min; injection volume: 20μL; column temperature: 40℃; detection wavelength: 232nm

(3) Solution preparation

A) Enzymatic buffer:

Weigh 27.4g of sodium dihydrogen phosphate (NaH ₂ PO ₄ ·2H ₂ O) and 8.8g of disodium hydrogen phosphate (Na ₂ HPO ₄ ·12H ₂ O) into a 1000mL volumetric flask, add water to dilute to the mark, shake well, and get 0.2mol/L NaH ₂ PO ₄ -Na ₂ HPO ₄ buffer, dilute the buffer 40 times to obtain enzymatic hydrolysis buffer (5mM/L NaH ₂ PO ₄ -Na ₂ HPO ₄ buffer, pH 6.0)

B) Control solution:

Precisely weigh about 50 mg of the sodium hyaluronate reference substance into a 50 mL volumetric flask, dissolve the enzymatic hydrolysis buffer and adjust the volume to the mark, and mix well. Take 0.5 mL of the above solution and place it in a 10 mL volumetric flask, add 5 mL of enzymatic buffer and 0.5 mL of hyaluronidase, mix, seal, enzymolyze at 42°C for 2 hours, boil for 2 minutes to inactivate the enzyme, and dilute the enzymatic buffer to volume to the mark, and filter with a 0.22 μm filter membrane to obtain the reference solution.

C) Solid test sample:

Weigh 15-18g of imitation leather, place it in a narrow-mouth glass bottle, accurately record the quality of the imitation leather, add enzymatic hydrolysis buffer, the volume of the buffer should be enough to immerse the imitation leather, add 0.5mL hyaluronidase, mix well, Seal, enzymolyze at 42°C for 2 hours, boil for 2 minutes to inactivate the enzyme, dilute the enzymatic buffer to volume, and filter with a 0.22 μm filter membrane to obtain the test solution. Prepare two copies in parallel.

D) Determination:

Inject 20 μL of the reference solution and the test solution respectively, record the chromatogram, and calculate the HA content (μg/g) in the imitation leather according to the following formula

In the formula: As is the peak area of the test solution, Mr is the weighed sample amount of the reference substance (mg); Z is the content of the reference substance; h% is the weight loss on drying of the reference substance; Vr is the volume of the reference substance solution (mL); Ar is the control The peak area of product solution; M _{imitation leather} is the quality of imitation leather.

Table 4 Migration rate of HA

Note: The hyaluronic acid in paper towels is considered qualified if its migration rate is above 5%. If the migration rate is below 5%, it will not achieve the skin care effect.

The above are only preferred embodiments of the present invention, and are not intended to limit the present invention in other forms. Any skilled person familiar with the art may make changes or modifications to equivalent changes using the technical contents disclosed above. Example. However, any simple modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention still fall within the protection scope of the technical solution of the present invention.

Claims

A finishing liquid composition containing hyaluronic acid or a salt thereof and a hydrophobic substance.
The composition according to claim 1, wherein the hydrophobic substance is a grease or wax. Preferably, the grease or wax is a hydrocarbon substance or a mixture of a hydrocarbon substance and a non-hydrocarbon substance.
The composition according to claim 2, wherein the carbon number of the hydrocarbon material is 10-60, preferably 28-52, and further preferably, the hydrocarbon material is squalane, mineral oil and/or Or petrolatum, preferably petrolatum.
The composition according to claim 2 or 3, wherein the non-hydrocarbon substance is a non-hydrocarbon substance of plant origin, animal origin and/or artificial synthesis. Preferably, the non-hydrocarbon substance is selected from triglycerides. One or more of ester, diglyceride, monoglyceride, ester wax and silicone oil.
The composition according to any one of claims 1 to 4, wherein the molecular weight of the hyaluronic acid or its salt is 1w-150wDa, preferably 20w-80wDa.
The composition according to any one of claims 1 to 4, wherein the hyaluronic acid or a salt thereof is cross-linked hyaluronic acid or a salt thereof.
The composition according to any one of claims 1 to 6, wherein the finishing liquid composition further comprises an emulsifier. Preferably, the emulsifier is a nonionic or anionic surfactant. Preferably, the emulsifier The non-ionic surfactant is selected from Tween-20, Tween-80, Cetearyl-6, Cetearyl-25, Cetearyl Olivate and Sorbitan Olive One or two or more oleic acid esters. Preferably, the anionic surfactant is selected from sodium stearyl glutamate, sodium laurate, sodium dodecyl benzene sulfonate, and sodium lauryl sulfate. and sodium oleate.
The composition according to any one of claims 1 to 7, wherein the hyaluronic acid or its salt is 0.01-0.5%, preferably 0.1-0.2% in terms of mass percentage in the composition. ;

Preferably, the hydrophobic substance is 0.5-25%, more preferably 5-20%.
The composition according to any one of claims 1 to 8, wherein the composition further comprises glycerol and water-soluble active ingredients. Preferably, the water-soluble active ingredients include ectoine, ergothioneine, One or more of γ-aminobutyric acid, amino acids and proteins.
Use of the composition according to any one of claims 1 to 9 in paper products.
A tissue containing a composition of hyaluronic acid or a salt thereof and a hydrophobic substance.
The paper towel according to claim 11, wherein the hydrophobic substance is grease or wax, Preferably, the grease or wax is a hydrocarbon material or a mixture of hydrocarbon material and non-hydrocarbon material.
The paper towel according to claim 12, wherein the carbon number of the hydrocarbon material is 10-60, preferably 28-52, and further preferably, the hydrocarbon material is squalane, mineral oil and/or Petrolatum, preferably petrolatum.
The paper towel according to claim 12 or 13, wherein the non-hydrocarbon substance is a non-hydrocarbon substance of plant origin, animal origin and/or artificial synthesis. Preferably, the non-hydrocarbon substance is selected from triglycerides. , one or more of diglyceride, monoglyceride, ester wax and silicone oil.
The paper towel according to any one of claims 11 to 14, wherein the molecular weight of the hyaluronic acid or its salt is 1w-150wDa, preferably 20w-80wDa.
The paper towel according to any one of claims 11 to 14, wherein the hyaluronic acid or a salt thereof is cross-linked hyaluronic acid or a salt thereof.
The paper towel according to any one of claims 11 to 16, wherein the composition further comprises an emulsifier. Preferably, the emulsifier is a nonionic or anionic surfactant. Preferably, the nonionic surface The active agent is selected from Tween-20, Tween-80, Cetearyl-6, Cetearyl-25, Cetearyl Olivate and Sorbitan Olivate One or two or more of them, preferably, the anionic surfactant is selected from sodium stearoyl glutamate, sodium laurate, sodium dodecyl benzene sulfonate, sodium lauryl sulfate and oleic acid One or more than two types of sodium.
The paper towel according to any one of claims 11 to 17, wherein the content of the hyaluronic acid or its salt in the paper towel is 5-5000 ppm, preferably 300-900 ppm, and further preferably 300-500 ppm.
The paper towel according to any one of claims 11 to 18, wherein the content of the hydrophobic substance in the paper towel is 0.1-6%, preferably 2-5%.
The paper towel according to any one of claims 11 to 19, wherein the composition containing hyaluronic acid or a salt thereof and a hydrophobic substance further contains glycerin and a water-soluble active ingredient. Preferably, the water-soluble active ingredient The ingredients include one or more of ectoine, ergothioneine, γ-aminobutyric acid, amino acids and protein.
The paper towel according to any one of claims 11 to 20, wherein the mobility of the hyaluronic acid or its salt is ≥1%, preferably ≥5%.
The paper towel according to any one of claims 11-21, wherein the paper towel contains cellulose fiber, preferably, the content of the cellulose fiber is ≥50%.
The use of hydrophobic substances to increase the mobility of hyaluronic acid during tissue rubbing.
According to the use of claim 23, the hydrophobic substance is grease or wax. Preferably, the grease or wax is a hydrocarbon substance or a mixture of hydrocarbon substances and non-hydrocarbon substances;

Preferably, the carbon number of the hydrocarbon material is 10-60, preferably 28-52;

Further preferably, the hydrocarbon material is squalane, mineral oil and/or petrolatum, preferably petrolatum.