WO2023161949A1 - A synergistic fungicidal composition comprising picoxystrobin, copper oxychloride and soy protein - Google Patents
A synergistic fungicidal composition comprising picoxystrobin, copper oxychloride and soy protein Download PDFInfo
- Publication number
- WO2023161949A1 WO2023161949A1 PCT/IN2022/050405 IN2022050405W WO2023161949A1 WO 2023161949 A1 WO2023161949 A1 WO 2023161949A1 IN 2022050405 W IN2022050405 W IN 2022050405W WO 2023161949 A1 WO2023161949 A1 WO 2023161949A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fungicidal composition
- present
- picoxystrobin
- copper oxychloride
- granules
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 83
- 230000000855 fungicidal effect Effects 0.000 title claims abstract description 65
- 239000005752 Copper oxychloride Substances 0.000 title claims abstract description 31
- 239000005818 Picoxystrobin Substances 0.000 title claims abstract description 31
- IBSNKSODLGJUMQ-SDNWHVSQSA-N picoxystrobin Chemical compound CO\C=C(\C(=O)OC)C1=CC=CC=C1COC1=CC=CC(C(F)(F)F)=N1 IBSNKSODLGJUMQ-SDNWHVSQSA-N 0.000 title claims abstract description 31
- HKMOPYJWSFRURD-UHFFFAOYSA-N chloro hypochlorite;copper Chemical compound [Cu].ClOCl HKMOPYJWSFRURD-UHFFFAOYSA-N 0.000 title claims abstract description 29
- 108010073771 Soybean Proteins Proteins 0.000 title claims abstract description 28
- 229940001941 soy protein Drugs 0.000 title claims abstract description 28
- 230000002195 synergetic effect Effects 0.000 title abstract description 9
- 235000007164 Oryza sativa Nutrition 0.000 claims abstract description 32
- 235000009566 rice Nutrition 0.000 claims abstract description 32
- 240000007594 Oryza sativa Species 0.000 claims abstract 3
- 239000008187 granular material Substances 0.000 claims description 22
- 239000004480 active ingredient Substances 0.000 claims description 12
- 238000009472 formulation Methods 0.000 claims description 11
- 239000002270 dispersing agent Substances 0.000 claims description 10
- 239000000080 wetting agent Substances 0.000 claims description 10
- 239000002518 antifoaming agent Substances 0.000 claims description 9
- 239000004495 emulsifiable concentrate Substances 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 239000004546 suspension concentrate Substances 0.000 claims description 8
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 7
- 238000000227 grinding Methods 0.000 claims description 6
- 239000004562 water dispersible granule Substances 0.000 claims description 6
- 241000607479 Yersinia pestis Species 0.000 claims description 5
- 239000011230 binding agent Substances 0.000 claims description 5
- 239000000839 emulsion Substances 0.000 claims description 5
- 230000009969 flowable effect Effects 0.000 claims description 4
- 239000004530 micro-emulsion Substances 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 4
- 239000000725 suspension Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
- 244000147568 Laurus nobilis Species 0.000 claims description 3
- 235000017858 Laurus nobilis Nutrition 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 3
- 235000005212 Terminalia tomentosa Nutrition 0.000 claims description 3
- 239000008101 lactose Substances 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 159000000000 sodium salts Chemical class 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 229910021653 sulphate ion Inorganic materials 0.000 claims description 3
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 2
- TVFWYUWNQVRQRG-UHFFFAOYSA-N 2,3,4-tris(2-phenylethenyl)phenol Chemical compound C=1C=CC=CC=1C=CC1=C(C=CC=2C=CC=CC=2)C(O)=CC=C1C=CC1=CC=CC=C1 TVFWYUWNQVRQRG-UHFFFAOYSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 2
- 229930195725 Mannitol Natural products 0.000 claims description 2
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- -1 alkyl naphthalene sulfonate Chemical compound 0.000 claims description 2
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-ASMJPISFSA-N alpha-maltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-ASMJPISFSA-N 0.000 claims description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims description 2
- 235000011130 ammonium sulphate Nutrition 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical group OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 2
- 229920001400 block copolymer Polymers 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 239000008121 dextrose Substances 0.000 claims description 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 229930195729 fatty acid Natural products 0.000 claims description 2
- 239000000194 fatty acid Substances 0.000 claims description 2
- 150000004665 fatty acids Chemical class 0.000 claims description 2
- 229930182830 galactose Natural products 0.000 claims description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 2
- 239000000594 mannitol Substances 0.000 claims description 2
- 235000010355 mannitol Nutrition 0.000 claims description 2
- 150000004812 organic fluorine compounds Chemical class 0.000 claims description 2
- 229920001296 polysiloxane Polymers 0.000 claims description 2
- 229920005552 sodium lignosulfonate Polymers 0.000 claims description 2
- HLPHHOLZSKWDAK-UHFFFAOYSA-M sodium;formaldehyde;naphthalene-1-sulfonate Chemical compound [Na+].O=C.C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1 HLPHHOLZSKWDAK-UHFFFAOYSA-M 0.000 claims description 2
- 239000004550 soluble concentrate Substances 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- UHZZMRAGKVHANO-UHFFFAOYSA-M chlormequat chloride Chemical compound [Cl-].C[N+](C)(C)CCCl UHZZMRAGKVHANO-UHFFFAOYSA-M 0.000 claims 5
- 238000001035 drying Methods 0.000 claims 1
- 238000010902 jet-milling Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 abstract description 11
- 230000000694 effects Effects 0.000 abstract description 5
- 208000031888 Mycoses Diseases 0.000 abstract description 3
- 238000003912 environmental pollution Methods 0.000 abstract description 2
- 206010017533 Fungal infection Diseases 0.000 abstract 2
- 241000209094 Oryza Species 0.000 description 29
- 241000196324 Embryophyta Species 0.000 description 19
- 238000011282 treatment Methods 0.000 description 19
- 230000006378 damage Effects 0.000 description 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 16
- 239000000417 fungicide Substances 0.000 description 16
- 208000027418 Wounds and injury Diseases 0.000 description 15
- 201000010099 disease Diseases 0.000 description 15
- 208000014674 injury Diseases 0.000 description 15
- 230000000885 phytotoxic effect Effects 0.000 description 13
- 210000003462 vein Anatomy 0.000 description 13
- 230000036253 epinasty Effects 0.000 description 12
- 231100000674 Phytotoxicity Toxicity 0.000 description 10
- 241000233866 Fungi Species 0.000 description 9
- 239000000126 substance Substances 0.000 description 6
- 230000001276 controlling effect Effects 0.000 description 5
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 4
- 229910052802 copper Inorganic materials 0.000 description 4
- 239000010949 copper Substances 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 230000018109 developmental process Effects 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 230000002538 fungal effect Effects 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 229940024606 amino acid Drugs 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 239000000306 component Substances 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000010076 replication Effects 0.000 description 3
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 2
- 241000426497 Chilo suppressalis Species 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- 229960001375 lactose Drugs 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000017074 necrotic cell death Effects 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 235000014698 Brassica juncea var multisecta Nutrition 0.000 description 1
- 235000006008 Brassica napus var napus Nutrition 0.000 description 1
- 240000000385 Brassica napus var. napus Species 0.000 description 1
- 235000006618 Brassica rapa subsp oleifera Nutrition 0.000 description 1
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 1
- 208000003643 Callosities Diseases 0.000 description 1
- 102000018832 Cytochromes Human genes 0.000 description 1
- 108010052832 Cytochromes Proteins 0.000 description 1
- LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 206010020649 Hyperkeratosis Diseases 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- ZTCLCSCHTACERP-AWEZNQCLSA-N N-[(1S)-1-[3-chloro-5-fluoro-2-[[2-methyl-4-(2-methyl-1,2,4-triazol-3-yl)quinolin-8-yl]oxymethyl]phenyl]ethyl]-2-(difluoromethoxy)acetamide Chemical compound C1=C(C=C(C(=C1Cl)COC1=CC=CC2=C(C=3N(N=CN=3)C)C=C(C)N=C12)[C@@H](NC(=O)COC(F)F)C)F ZTCLCSCHTACERP-AWEZNQCLSA-N 0.000 description 1
- 240000004713 Pisum sativum Species 0.000 description 1
- 235000010582 Pisum sativum Nutrition 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 235000019764 Soybean Meal Nutrition 0.000 description 1
- 229930182692 Strobilurin Natural products 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000003254 anti-foaming effect Effects 0.000 description 1
- 230000001857 anti-mycotic effect Effects 0.000 description 1
- 239000002543 antimycotic Substances 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 230000001764 biostimulatory effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000004464 cereal grain Substances 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 229960003067 cystine Drugs 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229940125532 enzyme inhibitor Drugs 0.000 description 1
- 239000002532 enzyme inhibitor Substances 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 230000035784 germination Effects 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- ZKVLEFBKBNUQHK-UHFFFAOYSA-N helium;molecular nitrogen;molecular oxygen Chemical compound [He].N#N.O=O ZKVLEFBKBNUQHK-UHFFFAOYSA-N 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- 229960001021 lactose monohydrate Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 230000006540 mitochondrial respiration Effects 0.000 description 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-M naphthalene-1-sulfonate Chemical compound C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-M 0.000 description 1
- 230000000361 pesticidal effect Effects 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 231100000208 phytotoxic Toxicity 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000027756 respiratory electron transport chain Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000004455 soybean meal Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000004563 wettable powder Substances 0.000 description 1
- 238000004383 yellowing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P3/00—Fungicides
Definitions
- Copper oxychloride is a copper based broad spectrum fungicide which controls the fungal as well as bacterial diseases by its contact action. It also effectively controls the fungus resistant to other fungicides. Due to its fine particles, it sticks to the leaves and helps to restrict the growth of the fungus. It is a broad-spectrum contact fungicide with protective action. Copper because of its strong bonding affinity to amino acids and carboxyl groups, reacts with protein and acts as an enzyme inhibitor in target organisms. Copper kills spores by combining with sulphahydral groups of certain enzymes. Spores actively accumulate copper and thus germination of spores is inhibited, even at lower concentrations. Copper oxychloride can be described by the following formula;
- the at least a dispersing agent is selected from the group consisting of sodium lignosulphonates, sodium naphthalene sulphonate- formaldehyde condensates, aliphatic alcohol ethoxylates, tristyrylphenol ethoxylates and esters, ethylene oxide/propylene oxide block copolymers, and combinations thereof.
- the at least a dispersing agent is sodium salt of naphthalene sulfonate condensate.
- the at least a dispersing agent weight concentration in said fungicidal composition is in the range of 5 to 10 %w/w. In a preferred embodiment, the dispersing agent is present in an amount of 7% w/w.
- the mixture was subjected to grinding through a jet mill and grinding was carried out until a mean particle size of below 10 micron was obtained.
- Example 4 Fungicidal treatment on rice blast at 20 days after 1st and 2nd application was tested for CF 0740 WG comprising Picoxystrobin 7% + Copper oxychloride 40%+ Soy protein 0.5%WG.
- Table 7 Effect of fungicide treatments on Rice blast disease at 20 days after 1 st and 2 nd Application
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention provides a synergistic fungicidal composition comprising picoxystrobin, copper oxychloride, and soy protein, which at particular weight concentrations exhibits superior control over fungal infection in crops, particularly rice. The composition exhibits superior effect against fungal infection particularly when used at concentrations lesser than approved/suggested amounts if used separately. The composition is economical, cheaper and creates reduced environmental pollution due to reduced usage of active compounds picoxystrobin and copper oxychloride.
Description
A SYNERGISTIC FUNGICIDAL COMPOSITION COMPRISING PICOXYSTROBIN, COPPER OXYCHLORIDE AND SOY PROTEIN
FIELD OF THE INVENTION
The present invention is related to a stable synergistic fungicidal composition comprising synergistically effective amount of three actives. The instant invention of synergistic fungicidal composition comprises Picoxystrobin in combination with copper oxychloride and soy protein that providing significant broad-spectrum efficacy without causing any phytotoxicity to any part of the plant. The present invention is also related to a process for the preparation of said fungicidal composition.
BACKGROUND OF THE INVENTION
Fungicides are compounds, of natural or synthetic origin, which act to protect plants against damage caused by fungi. Current methods of agriculture rely heavily on the use of fungicides. In fact, some crops cannot be grown usefully without the use of fungicides. Using fungicides allows a grower to increase the yield and the quality of the crop and consequently, increase the value of the crop. In most situations, the increase in value of the crop is worth at least three times the cost of the use of the fungicide.
Various compositions have been developed to control fungi. Practical agricultural experience has shown that the repeated and exclusive application of an individual active compound for the control of harmful fungi in many cases leads to rapid development of those strains which have developed natural or adapted resistance against the active compound in question. Effective control of these fungi with the active compound in question is very difficult in such cases. To reduce the risk of development of resistant strains, mixtures of different active compounds are nowadays conventionally employed for controlling harmful fungus or pests. It is possible to ensure successful control over a relatively long period of time by combining active compounds having different mechanisms of action. Most crop and ornamental plants are subject to attack by several fungi. Damage due to plant diseases to ornamentals, vegetable, field, cereal and fruit crops can cause significant reduction in productivity and thereby result in increased costs to the consumer. Serious disorders in combination or singly has resulted in the need for broad-spectrum disease control. Although there are available numerous chemical compounds (fungicides), which
aid in preventing diseases of plants, each of these have practical deficiencies, which restrict their use.
Combinations of fungicides are often used to facilitate disease control, to broaden spectrum of control and to retard resistance development. Accordingly, new advantageous combinations are needed to provide a variety of options to best satisfy particular plant disease control needs. Furthermore, certain rare combinations of fungicides demonstrate a greater-than-additive (i.e., synergistic) effect to provide commercially important levels of plant disease control. When two or more substances in combination demonstrate unexpectedly high biological activity, for example fungicidal activity, the resultant phenomenon may be referred to as synergism.
When two or more substances in combination demonstrate unexpectedly high biological activity, for example fungicidal activity, the resultant phenomenon may be referred to as synergism.
Picoxystrobin is a chemical compound from the strobilurins and methoxyacrylaytes. It is a systemic and trans -laminar, Quinone outside inhibitor (Qol) fungicide with preventive, curative and systemic activity for use on canola, cereal grain (no rice), dried peas, corns and soybeans. It inhibits mitochondrial respiration by blocking electron transfer at the Qo center of cytochrome bcl Picoxystrobin can be described by the following formula;
Copper oxychloride is a copper based broad spectrum fungicide which controls the fungal as well as bacterial diseases by its contact action. It also effectively controls the fungus resistant to other fungicides. Due to its fine particles, it sticks to the leaves and helps to restrict the growth of the fungus. It is a broad-spectrum contact fungicide with protective action. Copper because of its strong bonding affinity to amino acids and carboxyl groups, reacts with protein and acts as an enzyme inhibitor in target organisms. Copper kills spores by combining with sulphahydral groups of certain enzymes. Spores actively accumulate copper and thus germination of spores is inhibited, even at lower concentrations. Copper oxychloride can be described by the following formula;
Soy protein basically serve as plant-derived biostimulants which are readily available in the markets. Traditionally, it is made from soybean meal that has been dehulled and defatted. Soyprotein extract contains various amino acids - Aspartic, Threonine, Serine, Glutamic acid, Proline, Glycine, Valine, Cystine, Isoleucine, Methionine, Tyrosine, Phenylalanine, Lysine, Histidine, Arginine, and the percentage of each amino acid may vary in the mixture. Soy protein has a bio-stimulating effect on the health of the crops.
OBJECTS OF THE INVENTION
It is an object of the present invention to provide a novel, synergistic, broad spectrum Fungicidal combination of Picoxystrobin, Copper oxychloride and soy protein for effective control of Blast in agricultural crops, particularly Rice crop.
SUMMARY OF THE INVENTION
The present invention discloses a composition that comprises a first active ingredient Picoxystrobin, a second active ingredient Copper oxy chloride and a third active ingredient soy protein along with agriculturally acceptable excipients. The pesticidal combination of present invention is useful in controlling fungal pests, particularly in paddy and other agricultural crops.
DETAILED DESCRIPTION OF THE INVENTION
Those skilled in the art will be aware that the invention described herein is subject to variations and modifications other than those specifically described. It is to be understood that the invention described herein includes all such variations and modifications. The invention also includes all such steps, features, compositions and compounds referred to or indicated in this specification, individually or collectively, and all combinations of any two or more of said steps or features.
Unless otherwise specified, all terms used in disclosing the invention, including technical and scientific terms, have the meaning as commonly understood by one of the ordinary skill in the
art to which the invention belongs. For further guidance, term definitions may be included to better appreciate the teaching of the present invention.
As used herein, the term "plant" refers to any plant or part thereof including serial and subterranean parts of the plant. It is contemplated that the parts of the plant may be for example, flowers, fruits or vegetables, shoots, leaves, needles, stalks, stems, fruiting bodies, seeds also roots and that parts of the plants may or may not be attached to the remainder of the plant
The term 'disease control' as used herein denotes control and prevention of a disease. Controlling effects include all deviation from natural development, for example: killing, retardation, decrease of the pests. The term 'plants' refers to all physical parts of a plant, including seeds, seedlings, saplings, roots, tubers, stems, stalks, foliage and fruits.
It is to be understood that the singular forms "a," "an," and "the" include plural referents unless the context clearly dictates otherwise.
Features that are described and/or illustrated with respect to one embodiment may be used in the same way or in a similar way in one or more other embodiments and/or in combination with or instead of the features of the other embodiments.
It should be emphasized that the term "comprises/comprising" when used in this specification is taken to specify the presence of stated features, steps or components but does not preclude the presence or addition of one or more other features, steps, components or groups thereof.
The term "fungicidal" also called antimycotic, any toxic substance used to kill or inhibit the growth of fungi.
The terms "weight percent", "wt-%", "percent by weight", "% by weight" and variations thereof, as used herein, refer to the concentration of a substance as the weight of that substance divided by the total weight of the composition and multiplied by 100. It is understood that, as used here, "percent ", "%" and the like are intended to be synonymous with "weight percent", "wt. %", etc.
As used herein, the term "agriculturally acceptable excipient" refers to an ingredient, additive, component or supplement, liquid or solid, suitable for incorporation in agricultural compositions.
The present invention provides a fungicidal composition comprising a) Picoxystrobin as the first active ingredient b) Copper oxychloride as the second active ingredient and c) Soy protein as the third active ingredient, wherein Picoxystrobin is present in an amount ranging from 5-50% w/w, Copper oxychloride is present in an amount ranging from 25-60 % w/w, soy protein is present in an amount ranging from 1-10% w/w. In a preferred embodiment, Picoxystrobin is present in an amount of 10% w/w, Copper oxychloride is present in an amount of 35% w/w, soy protein is present in an amount of 1% w/w of the fungicidal composition.
In an embodiment, the fungicidal composition of the present invention comprising the said actives exhibits synergistic effect in control of fungal in agricultural crops, particularly in rice crop.
Surprisingly, the present inventors have now found that the presently claimed fungicidal composition when applied at significantly lesser dosages than recommended dosages when applied separately, exhibit superior efficacy as measured in terms of percent control of target pest. In other words, it was surprising to find that these conventional rice fungicides when combined at desired weight percentages at reduced individual Al (Active Ingredient) dosages, the resulting efficacy in controlling blast in paddy is unexpectedly enhanced.
Further surprisingly, it has been found that the active compound combination of the presently claimed composition exhibits a synergistic effect and not merely an additive effect. Thus, clearly, the customary dosages of the individual actives are substantially reduced, leading to lesser amount of soil residues and environmental pollution when the composition of the present invention is used.
In an embodiment, the fungicidal composition further comprises at least one agriculturally acceptable excipient. In an embodiment, the at least one excipient is selected from the group consisting of at least a wetting agent, at least a dispersing agent, at least a defoaming agent, at least a binder, at least a suitable carrier, and combinations thereof. In a preferred embodiment, the fungicidal composition is in the form of a wettable granule formulation further comprising at least a wetting agent, at least a dispersing agent, at least a defoaming agent, at least a binder, and at least a suitable carrier.
In an embodiment, the at least a dispersing agent is selected from the group consisting of sodium lignosulphonates, sodium naphthalene sulphonate- formaldehyde condensates, aliphatic alcohol ethoxylates, tristyrylphenol ethoxylates and esters, ethylene oxide/propylene oxide block
copolymers, and combinations thereof. In a preferred embodiment, the at least a dispersing agent is sodium salt of naphthalene sulfonate condensate. The at least a dispersing agent weight concentration in said fungicidal composition is in the range of 5 to 10 %w/w. In a preferred embodiment, the dispersing agent is present in an amount of 7% w/w.
In an embodiment, the at least a wetting agent is selected from the group consisting of blend of alkyl naphthalene sulfonate, sodium salt, sodium laurel sulphate, and combinations thereof. In a preferred embodiment, the at least a wetting agent is sodium laurel sulphate. The at least a wetting agent weight concentration in said fungicidal composition is in the range of 2 to 5% w/w. In a preferred embodiment, the wetting agent is present in an amount of 3% w/w.
In an embodiment, the at least an anti-foaming is selected from the group consisting of silicone emulsions, long-chain alcohols, fatty acids, organic fluorine compounds, and combinations thereof. The at least an anti-foaming agent weight concentration in said fungicidal composition is in the range of 0.1 to .3% w/w. In a preferred embodiment, the antifoaming agent is present in an amount of 0.10% w/w.
In an embodiment, the at least a binder is selected from the group consisting of Starch paste, Hydroxypropyl methyl cellulose (HPMC), lactose Polyvinyl Pyrrolidone (PVP), Lactose monohydrate, and combinations thereof
In an embodiment, the at least a carrier is selected from the group consisting of dextrose, lactose, soluble starch, galactose, amylodextrin, ammonium sulfate, maltose, mannitol, sucrose, sorbitol, china clay, EDTA (Ethylenediaminetetraacetic acid) and combinations thereof. The at least a carrier weight concentration in said fungicidal composition is in the range of 4 to 8% w/w. In a preferred embodiment, the antifoaming agent is present in an amount of 6% w/w.
In an embodiment, the fungicidal composition is formulated in a form selected from the group consisting of water-soluble concentrates (SL), emulsifiable concentrates (EC), emulsions (EW), micro-emulsions (ME), Suspension concentrates (SC), oil-based suspension concentrates (OD), flowable suspensions (FS), water-dispersible granules (WG), water-soluble granules (SG), wettable powders (WP), water soluble powders (SP), granules (GR), encapsulated granules (CG), fine granules (FG), macrogranules (GG), dry flowables (DF), aqueous Suspo-emulsions (SE), capsule suspensions (CS) and microgranules (MG). In a preferred embodiment, the fungicidal
composition is in the form of suspension concentrates (SC), water-dispersible granule (WDG) and wettable powder (WP).
In a more preferred embodiment, the fungicidal composition of the present invention is formulated in the form of water dispersible granule (WDG) comprising a wetting agent, a dispersing agent, a defoaming agent, a binder and a suitable carrier.
The present invention also provides a method for controlling insects in agricultural crops, particularly in rice crop, said method comprising treating rice crop with a fungicidal composition comprising a) Picoxystrobin b) Copper oxychloride and c) Soy protein, wherein Picoxystrobin is present in an amount ranging from 5-50 % w/w, Copper oxychloride is present in an amount ranging from 25-60 % w/w and Soy protein is present in an amount ranging from 1-10 % w/w of the fungicidal composition.
In a preferred embodiment, Picoxystrobin is present in an amount of 10% w/w, Copper oxychloride is present in an amount of 35% w/w and Soy protein is present in an amount of 1% w/w of the fungicidal composition. The fungicidal composition is as described substantially in the present disclosure.
The present invention further provides a process of preparing a fungicidal composition comprising a) Picoxystrobin b) Copper oxychloride and c) Soy protein, wherein Picoxystrobin is present in an amount ranging from 5-50% w/w, Copper oxychloride is present in an amount ranging from 25-60% w/w and Soy protein is present in an amount ranging from 1-10% w/w of the fungicidal composition; as a water-dispersible formulation, said process comprising the following steps:
1. The desired quantity of active ingredients and excipients were weighed and mixed in a blender.
2. The mixture was subjected to grinding through a jet mill and grinding was carried out until a mean particle size of below 10 micron was obtained.
3. The homogenous mix was again put in a blender and a dough was prepared by dough mixer.
4. The granules were prepared by carrying the dough through an extruder.
5. The granules thus prepared were dried by using hot air or and oven.
6. The dried granules were checked for quality parameters (described in example 1 below)
EXAMPLES
The examples below are given solely for the purpose of illustration and are not to be construed as limitations of the present invention, as many variations thereof are possible without departing from the spirit and scope of the invention.
Example 1: Preparation of fungicidal composition as wettable granule (WG)
Table 1 below provides a fungicidal composition as described in the present specification, formulated as a wettable granule (WG)
Preparation method of WG
The desired quantity of the active ingredients and adjuvants were weighed and mixed in a blender. The mixture was then subjected to grinding through a jet mill and grinding was carried out until a mean particle size of below 10 micron was obtained. After grinding, the homogenous
mix was again put in a blender and a dough was prepared by dough mixer. After this step, granules were prepared by carrying the dough through an extruder. The granules thus prepared were then dried by using hot air or and oven. The dried granules were then checked for quality parameters. Fig 1 shows a flow diagram representation of the steps involved in the preparation of the WG the Formulation Fl was tested for quality parameters as per the standard protocols and, the important quality parameters are listed below:
Table 2: Quality parameters of WG formulation
Example 2: Field evaluation of the bioefficacy of the present fungicidal composition The presently disclosed fungicidal trimix (coded as CF-1035 WG) was tested for its bioefficacy against fungal on rice crop and variety local and kharif season 2020 at Nashik, Maharashtra. The plants were aligned in a plot size of 50 sq. meter. The trial was laid out in a random block design consisting of a total of 11 treatments in three replications. The trial was conducted at a temp, of 35°C under 70% relative humidity, no winds and under optimum soil moisture conditions.
Measured quantity of the chemical was added to required volume of water @ 375 lit. /ha for spraying. The spray tank was filled with % the quantity of clean required volume of water and then the measured chemical (according to the dose) was added followed by the rest half quantity of water. The solution was stirred well before application. Knapsack sprayer fitted with boom along with flood jet nozzle was used to apply the fungicidal composition.
Table 3a below provides the treatment details of the rice crop in the trial experiment conducted. For purposes of convenience, the present composition has been represented by the code "CF- 1035" WG".
Note Sample-1 CCP-1035 WG Picoxystrobin 10% + Copper oxychloride 35% + Soy protein 1% WG
Sample-2 CCP-1035 WG Picoxystrobin 10% + Copper oxychloride 35% WG
Table 3(b) below provides the treatment details of the rice crop in the trial experiment conducted. For purposes of convenience, the present composition has been represented by the code "CF-1035" WG".
Note
Sample-1 CCP-0740 WG Picoxystrobin 7 % + Copper oxychloride 40% + Soy protein 0.5% WG
Sample-2 CCP-0740 WG Picoxystrobin 7 % + Copper oxychloride 40% WG
Table 3(c) below provides the treatment details of the rice crop in the trial experiment conducted. For purposes of convenience, the present composition has been represented by the code "CF-1035" WG".
Note
Sample-1 CCP-1538 WG Picoxystrobin 15 % +Copper oxychloride 38 % + Soy protein 2% WG
Sample-2 CCP-1538 WG Picoxystrobin 15 % +Copper oxychloride 38 % WG EVALUATION OF BIO-EFFICACY AGAINST DISEASE MANAGEMENT
Evaluation method for Blast disease -
Observe randomly selected 75 leaves /replication and 3 replication/plot and rate visually each disease as per the ratings below. Calculate the per cent disease index (PDI) as per given formula
Sum of numerical rating
PDI = - X 100
Total no. of plants/Leaves observed X Maximum grade
Table 4: Effect of fungicide treatments on rice blast disease at 20 days after 1st and 2nd application for CCP-1035 WG comprising Picoxystrobin 10% + Copper oxychloride 35% + Soy protein 1%
Table 4 shows the representation of the percent control achieved at 20 days after the after various treatments for the rice blast. T6 (112.5 + 394 + 11.25) gm a.i/hectare. No phytoxicity was observed in case of CCP 1035 WG . Data is shown in the below table.
Example 3: Evaluation of phytotoxicity of the present fungicidal composition
Visual observations were recorded at 3, 7 and 10 days after application (DAA) of testing products. The parameters observed were leaf injury on tip/surface, necrosis, vein clearing, epinasty, hyponasty and wilting. The score scale (1-10) followed for leaf injury on tips/surface is given below in Table.
Table 5: Phytotoxicity symptoms scoring and rating for leaf injury on tip/surface
Phytotoxicity studies
Table 6. Phytotoxic effect of various treatments on Rice crop after 3 DAA
DAA - Days after app ication,
L- Leaf injury on tips/surface, N-Necrosis, V- Vein clearing, E- Epinasty, H- Hyponasty, W-wilting
Table-6(a). Phytotoxic effect of various treatments on Rice crop after 7 DAA
Note:
DAA - Days after application,
L- Leaf injury on tips/surface, N-Necrosis, V- Vein clearing, E- Epinasty, H- Hyponasty, W-wilting
Table-6(b) Example-1 Phytotoxic effect of various treatments on Rice crop after 10 DAA
Example 4 Fungicidal treatment on rice blast at 20 days after 1st and 2nd application was tested for CF 0740 WG comprising Picoxystrobin 7% + Copper oxychloride 40%+ Soy protein 0.5%WG. Table 7: Effect of fungicide treatments on Rice blast disease at 20 days after 1st and 2nd Application
As seen in Table 7 a showing maximum percent of control of rice stem borer in CF-0740 WG at
87.5 + 50 + 18.75 gm a.i per hectare with phytotoxicity in higher closes (Shown in the below table)
Table-8. Example-2 Phytotoxic effect of various treatments on Rice crop after 3 DAA
DAA - Days after application,
L- Leaf injury on tips/surface, N-Necrosis, V- Vein clearing, E- Epinasty, H- Hyponasty, W-wilting
Table-8a Example-2 Phytotoxic effect of various treatments on Rice crop after 7 DAA
DAA - Days after application,
L- Leaf injury on tips/surface, N-Necrosis, V- Vein clearing, E- Epinasty, H- Hyponasty, W-wilting
Table-8b Example-2 Phytotoxic effect of various treatments on Rice crop after 10 DAA
DAA - Days after application,
L- Leaf injury on tips/surface, N-Necrosis, V- Vein clearing, E- Epinasty, H- Hyponasty, W-wilting
Phytotoxic studies:
Examples:
Fungicidal treatment on rice blast at 20 days after 1st and 2nd application was tested for CF-1583
WG comprising Picoxystrobin 15% + Copper oxy chloride 8% + Soy protein 3% WG.
Table-9.: Effect of fungicide treatments on rice blast disease at 20 days after 1st and 2nd Application
As seen in Table 9 showing maximum percent of control of rice stem borer in Cl- 1483 WG @ 87.5 + 50 + 18.75 gm a.i per hectare gm a.i per hectare with phytotoxicity in higher doses (Shown in the below table )
Table-9, a Example-3 Phytotoxic effect of various treatments on Rice crop after 3 DAA
DAA - Days after application,
L- Leaf injury on tips/surface, N-Necrosis, V- Vein clearing, E- Epinasty, H- Hyponasty, W-wilting
Table-9, b Example-3 Phytotoxic effect of various treatments on Rice crop after 7 DAA
DAA - Days after application,
L- Leaf injury on tips/surface, N-Necrosis, V- Vein clearing, E- Epinasty, H- Hyponasty, W-wilting
Table-9, c Example-3 Phytotoxic effect of various treatments on Rice crop after 10 DAA
DAA - Days after application,
L- Leaf injury on tips/surface, N-Necrosis, V- Vein clearing, E- Epinasty, H- Hyponasty, W-wilting
Example -6: Phytotoxicity of 2 different formulations (CCP-1035 WG & CCP-1035 EC)
Table-lOa Example-1 Phytotoxic effect of 2 different formulations of CCP-1035 WG & CCP-1035 EC on Rice crop after 3 DAA
DAA - Days after application,
L- Leaf injury on tips/surface, N-Necrosis, V- Vein clearing, E- Epinasty, H- Hyponasty, W-wilting Table-lOa. Example-2 Phytotoxic effect of 2 different formulations of CCP-1035 WG & CCP- 1035 EC on Rice crop after 7 DAA
DAA - Days after application,
L- Leaf injury on tips/surface, N-Necrosis, V- Vein clearing, E- Epinasty, H- Hyponasty, W-wilting
In Table 5 fungicidal mixture coded as CCP-1035 WG (Picoxystrobin 10% + Copper oxy chloride 35% + Soy Protein 1% WG) in all four doses (sample 1) showing no phytotoxicity. However, in sample 4(1035 EC) having phytotoxicity (yellowing on foliage, leaf tip injury, necrosis, vein clearing and in some plants hyponasty and wilting.)
Table-10, c Example-3 Phytotoxic effect of 2 different formulations of CCP-1035 WG & CCP- 1035 EC on Rice crop after 10 DAA
DAA - Days after application,
L- Leaf injury on tips/surface, N-Necrosis, V- Vein clearing, E- Epinasty, H- Hyponasty, W-wilting
Results and Conclusion
Table 4 showing that maximum percent control of Rice blast observed in CCP-1035 WG @ 100 + 350 + 10 gm a.i. per hectare to 112.5 + 394 + 11.25 gm a.i. per hectare without any phytotoxicity. Results was observed superior than other possible combinations.
Claims
I/We Claim:
1) An fungicidal composition comprising a) Picoxystrobin as first active ingredient b) copper oxychloride as second active ingredient and c) Soy protein as third active ingredient, wherein Picoxystrobin is present in an amount ranging from 5-50%w/w, Copper oxychloride is present in an amount ranging from 25-60%w/w, and soy protein is present in an amount ranging from l-10%w/w.
2) The fungicidal composition as claimed in claim 1, further comprising at least one agriculturally acceptable excipient.
3) The fungicidal composition as claimed in claim 1, wherein said fungicidal composition is formulated in a form selected from the group consisting of water-soluble concentrates (SL), emulsifiable concentrates (EC), emulsions (EW), micro-emulsions (ME), Suspension concentrates (SC), oil-based suspension concentrates (OD), flowable suspensions (FS), water-dispersible granules (WG), water- soluble granules (SG), wettable powders (WP), water soluble powders (SP), dry flowables (DF), granules (GR), encapsulated granules (CG), fine granules (FG), macrogranules (GG), aqueous Suspoemulsions (SE), capsule suspensions (CS) and microgranules (MG).
4) The fungicidal composition as claimed in claim 3, wherein said fungicidal composition is in the form of wettable granule (WG) formulation.
5) The fungicidal composition as claimed in claim 4, wherein said fungicidal composition further comprises at least a wetting agent, at least a dispersing agent, at least a defoaming agent, at binding agent and at least a carrier.
6) The fungicidal composition as claimed in claim 5, wherein said at least a dispersing agent is selected from the group consisting of sodium lignosulphonates, sodium naphthalene sulphonate- formaldehyde condensates, aliphatic alcohol ethoxylates, tristyrylphenol ethoxylates and esters, ethylene oxide/propylene oxide block copolymers, and combinations thereof; and wherein said at least a dispersing agent is present in an amount ranging from 5-10% w/w of the fungicidal composition.
) The fungicidal composition as claimed in claim 5, wherein said at least a wetting agent is selected from the group consisting of blend of alkyl naphthalene sulfonate, sodium salt, sodium laurel sulphate, and combinations thereof; and wherein said wetting agent is present in an amount ranging from 2-5% w/w of the fungicidal composition. ) The fungicidal composition as claimed in claim 5, wherein said at least an defoaming agent is selected from the group consisting of silicone emulsions, long-chain alcohols, fatty acids, organic fluorine compounds, and combinations thereof; and wherein said at least a defoaming agent is present in an amount ranging from 0.1-.3% w/w of the fungicidal composition. ) The fungicidal composition as claimed in claim 5, wherein said an at least a carrier is selected from the group consisting of dextrose, lactose, soluble starch, galactose, amylodextrin, ammonium sulfate, maltose, mannitol, sucrose, sorbitol, china clay, EDTA and combinations thereof, and wherein said at a carrier is present in an amount ranging from 4-8% w/w of the fungicidal composition. 0) The fungicidal composition as claimed in claim 1, wherein Picoxystrobin is present in an amount of 10% w/w, Copper oxychloride is present in an amount of 35% w/w, and Soy protein is present in an amount of 1% w/w of the fungicidal composition 1) A method for controlling pest in rice, said method comprising treating rice crop with a fungicidal composition as claimed in claim 1. 2) A process for preparing an fungicidal composition as claimed in claim 1 as a water-dispersible formulation, said process comprising: a) preparing a blend of Picoxystrobin, Copper oxychloride and, soy-protein, and suitable agriculturally acceptable excipients to obtain a first pre-mix; b) grinding the first pre-mix by jet-milling to obtain a second pre-mix having mean particle size of less than 10 microns; c) preparing a dough from the second pre-mix; d) subjecting the second pre-mix to an extruder to obtain granules; and e) drying the granules to obtain the water-dispersible formulation.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN202211009598 | 2022-02-23 | ||
| IN202211009598 | 2022-02-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2023161949A1 true WO2023161949A1 (en) | 2023-08-31 |
Family
ID=87765075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IN2022/050405 WO2023161949A1 (en) | 2022-02-23 | 2022-04-29 | A synergistic fungicidal composition comprising picoxystrobin, copper oxychloride and soy protein |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2023161949A1 (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2014DN01820A (en) * | 2011-09-13 | 2015-05-15 | Asahi Glass Co Ltd |
-
2022
- 2022-04-29 WO PCT/IN2022/050405 patent/WO2023161949A1/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2014DN01820A (en) * | 2011-09-13 | 2015-05-15 | Asahi Glass Co Ltd |
Non-Patent Citations (5)
| Title |
|---|
| KUMAR, M.K.P.; VEERABHADRASWAMY A.L. : "Appraise a combination of fungicides against blast and sheath blight diseases of paddy (Orvza sativa L.", JOURNAL OF EXPERIMENTAL BIOLOGY AND AGRICULTURAL SCIENCES, vol. 2, no. 1, 30 November 2013 (2013-11-30), pages 49 - 57, XP009548956, ISSN: 2320-8694 * |
| M. AUDISIO, C. CENGHIALTA, S. PASQUINI: "Picoxystrobin (Acanto®): four-year trials against rice diseases", PROCEEDINGS, PHYTOPATHOLOGICAL DAYS, CHIANCIANO TERME (SIENA), 18-21 MARCH 2014, UNIVERSITY OF BOLOGNA, IT, vol. 2, 18 March 2014 (2014-03-18) - 21 March 2014 (2014-03-21), IT, pages 1 - 8, XP009549479 * |
| MAHESH, M. ET AL.: "Bioefficacy of new fungicide (Picoxystrobin 7.5%+Tricyclazole 22.5% w/v) 30SC for the management of paddy blast caused by Pyricularia oryzae", ENVIRONMENT AND ECOLOGY, MKK PUBLICATION, CALCUTTA,, IN, vol. 34, no. 2A, 30 November 2015 (2015-11-30), IN , pages 767 - 772, XP009548978, ISSN: 0970-0420 * |
| NATH SABITA, MONDAL BHOLANATH: "EVALUATION OF NEWER FUNGICIDES IN MANAGING THE BLAST DISEASE OF RICE IN SUNDARBANS, WEST BENGAL, INDIA", PLANT ARCHIVES, vol. 20, no. 2, 1 January 2020 (2020-01-01), pages 4992 - 4996, XP093091166, ISSN: 0972-5210 * |
| QUDSIA HALIMA, AKHTER MUHAMMAD, RIAZ AWAIS, HAIDER ZULQARNAIN, MAHMOOD ABID: "Comparative Efficacy of Different Chemical Treatments for Paddy Blast, Brown Leaf Spot and Bacterial Leaf Blight Diseases in Rice (Oryza Sativa L.)", APPLIED MICROBIOLOGY: OPEN ACCESS, vol. 03, no. 03, XP093091169, DOI: 10.4172/2471-9315.1000138 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI617244B (en) | Fungicidal composition and the use thereof | |
| CN105766952B (en) | The bactericidal composition and its application of a kind of Fluxapyroxad-containsterilization and folpet | |
| KR100437065B1 (en) | Fungicide | |
| EA013928B1 (en) | Use of pyraclostrobin as safener for triticonazole for controlling harmful fungi | |
| WO2015135422A1 (en) | Method for protecting plant against plant disease | |
| WO2023161949A1 (en) | A synergistic fungicidal composition comprising picoxystrobin, copper oxychloride and soy protein | |
| TW200427407A (en) | Fungicidal mixtures for controlling rice pathogens | |
| CN103250702A (en) | Composite synergy sterilization composition containing boscalid and trifloxystrobin, and applications thereof | |
| CN105961396A (en) | Antibacterial composition containing fluoride ether bacteria amide and coumoxystrobin and application of composition | |
| CN105941438B (en) | A kind of bactericidal composition and its application of fluorine-containing ether bacterium amide and folpet | |
| CN106889079B (en) | A kind of bactericidal composition and its application containing fluoxastrobin and alkene oxime amine | |
| HUT73350A (en) | Fungicidal composition for seed treatment | |
| CN104642367A (en) | Bactericidal composition containing prothioconazole and prochloraz and application thereof | |
| JP2021511361A (en) | How to control anthrax in tropical fruit plants | |
| CN111316995B (en) | Pesticide composition, pesticide preparation and application of pesticide composition and pesticide preparation | |
| WO2022259259A1 (en) | Synergistic herbicidal composition | |
| WO2023058040A1 (en) | Ternary herbicidal composition | |
| CN110214783B (en) | Composition, preparation method and application thereof | |
| WO2023002497A1 (en) | Synergistic insecticidal composition | |
| CN105941440A (en) | Sterilization composition containing Bixafen and zineb and application thereof | |
| CN105941406B (en) | A kind of bactericidal composition and its application of fluorine-containing ether bacterium amide and SSF 126 | |
| JPH0269405A (en) | Plant growth regulating composition | |
| WO2022239016A1 (en) | Broad spectrum herbicidal composition for wheat | |
| RU2543816C1 (en) | Composition for improving pesticide effectiveness | |
| CN116035011A (en) | Weeding composition, herbicide and application thereof in lily crop fields |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 22928500 Country of ref document: EP Kind code of ref document: A1 |