WO2023143633A3 - Salvianolic acid a sodium salt hydrate and preparation method therefor - Google Patents

Salvianolic acid a sodium salt hydrate and preparation method therefor Download PDF

Info

Publication number
WO2023143633A3
WO2023143633A3 PCT/CN2023/082444 CN2023082444W WO2023143633A3 WO 2023143633 A3 WO2023143633 A3 WO 2023143633A3 CN 2023082444 W CN2023082444 W CN 2023082444W WO 2023143633 A3 WO2023143633 A3 WO 2023143633A3
Authority
WO
WIPO (PCT)
Prior art keywords
salvianolic acid
sodium salt
salt hydrate
preparation
method therefor
Prior art date
Application number
PCT/CN2023/082444
Other languages
French (fr)
Chinese (zh)
Other versions
WO2023143633A2 (en
Inventor
叶天健
阚士东
潘永存
张志杰
黄旭阳
温昱恺
彭仁贵
Original Assignee
台州永健医药科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 台州永健医药科技有限公司 filed Critical 台州永健医药科技有限公司
Publication of WO2023143633A2 publication Critical patent/WO2023143633A2/en
Publication of WO2023143633A3 publication Critical patent/WO2023143633A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/60—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention provides a salvianolic acid A sodium salt hydrate and a preparation method therefor. Specifically, the salvianolic acid A sodium salt hydrate provided by the present invention is a crystal formed by salvianolic acid A, salvianolic acid A negative ions, metal ions, and water molecules, has higher stability and better water solubility, and has lower production cost and higher purity.
PCT/CN2023/082444 2022-01-27 2023-03-20 Salvianolic acid a sodium salt hydrate and preparation method therefor WO2023143633A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202210098116.8 2022-01-27
CN202210098116.8A CN116554031A (en) 2022-01-27 2022-01-27 Salvianolic acid A sodium salt hydrate and preparation method thereof

Publications (2)

Publication Number Publication Date
WO2023143633A2 WO2023143633A2 (en) 2023-08-03
WO2023143633A3 true WO2023143633A3 (en) 2023-09-21

Family

ID=87470828

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2023/082444 WO2023143633A2 (en) 2022-01-27 2023-03-20 Salvianolic acid a sodium salt hydrate and preparation method therefor

Country Status (2)

Country Link
CN (1) CN116554031A (en)
WO (1) WO2023143633A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102976943A (en) * 2008-10-06 2013-03-20 中国医学科学院药物研究所 Alpha-crystal form substance of danshinolic acid A, preparation method, pharmaceutical composition and application
CN108341747A (en) * 2017-01-24 2018-07-31 浙江永宁药业股份有限公司 A kind of crystal form of salviandic acid A and preparation method thereof
CN110403928A (en) * 2019-07-17 2019-11-05 正大青春宝药业有限公司 A kind of salviandic acid A salt composite and its preparation method and application
CN113827587A (en) * 2020-06-24 2021-12-24 中国医学科学院药物研究所 Application of salvianolic acid A in preparing medicine for preventing thrombotic cerebral ischemia
CN115304486A (en) * 2021-05-06 2022-11-08 台州永健医药科技有限公司 Salvianolic acid A salt hydrate, preparation method and application thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102976943A (en) * 2008-10-06 2013-03-20 中国医学科学院药物研究所 Alpha-crystal form substance of danshinolic acid A, preparation method, pharmaceutical composition and application
CN108341747A (en) * 2017-01-24 2018-07-31 浙江永宁药业股份有限公司 A kind of crystal form of salviandic acid A and preparation method thereof
CN110403928A (en) * 2019-07-17 2019-11-05 正大青春宝药业有限公司 A kind of salviandic acid A salt composite and its preparation method and application
CN113827587A (en) * 2020-06-24 2021-12-24 中国医学科学院药物研究所 Application of salvianolic acid A in preparing medicine for preventing thrombotic cerebral ischemia
CN115304486A (en) * 2021-05-06 2022-11-08 台州永健医药科技有限公司 Salvianolic acid A salt hydrate, preparation method and application thereof
WO2022233310A1 (en) * 2021-05-06 2022-11-10 台州永健医药科技有限公司 Salvianolic acid a salt hydrate, preparation method therefor, and use thereof

Also Published As

Publication number Publication date
CN116554031A (en) 2023-08-08
WO2023143633A2 (en) 2023-08-03

Similar Documents

Publication Publication Date Title
CN103459409B (en) Manufacture the method for reduced glutathion
WO2007075865A3 (en) Electrolytic process to produce sodium hypochlorite using sodium ion conductive ceramic membranes
UA84683C2 (en) Fire retardant and a method for production thereof
RU2008102657A (en) ARTIFICIAL PHYSIOLOGICAL SALT SOLUTION AND PRODUCTION METHOD OF ITS PRODUCTION
WO2012076174A8 (en) Electrolyte for the electrochemical deposition of gold alloys and process for the production thereof
NO20075820L (en) Process for producing halide salts of alkaline and / or alkaline earth metals resulting from hydrolytic treatment of halogen-containing organic waste material
WO2012096993A3 (en) Control of ph kinetics in an electrolytic cell having acid-intolerant alkali-conductive membrane
EA201000129A1 (en) METHOD OF DIAFRAGMALYSIS AND APPLICATION OF PRODUCTS OBTAINED BY THIS METHOD
MX2022007148A (en) Method for preparation of 3,7-bis-(dimethylamino)-phenothiazin-5- ium chloride or bromide.
WO2023143633A3 (en) Salvianolic acid a sodium salt hydrate and preparation method therefor
MA33817B1 (en) PROCESS FOR PRODUCING PHOSPHORIC ACID
NO20080952L (en) Process for Electrolysis of Salt Melt, Electrolytic Cell, and Process for Preparation of Ti Using Said Process
NO20071762L (en) Process and reactor for the production of high purity silicon
MX2007013085A (en) Methods of forming an alkali metal salt.
DE502008002559D1 (en) PROCESS FOR THE PREPARATION OF CHLORIDE DIOXIDE
CY1112714T1 (en) PROCEDURE FOR THE PRODUCTION OF HIGH-CLEANANCE OF MELOXICAM AND POTASSIUM SILVER
FR2864787B1 (en) PROCESS FOR PRODUCING SODIUM CHLORIDE SOLUTION AND SODIUM HYPOCHLORURITE
CY1108469T1 (en) PROCEDURE FOR THE PRODUCTION OF GEMIFLOXAKIN ACID SALTS
WO2013068599A3 (en) Process for producing an anolyte composition
MX2021004516A (en) Method for producing lanthanum carbonate hydrate.
WO2006003395A3 (en) Molten salts, method of their production and process for generating hydrogen peroxide
MY149706A (en) Method for producing aqueous ?-sulfo fatty acid alkyl ester salt solution
EA201300100A3 (en) METHOD OF ENZYMATIC SYNTHESIS OF (7S) -3,4-DIMETOXYBICYCLO [4.2.0] OCTA-1,3,5-TRIEN-7-CARBONIC ACID OR ITS COMPLEX ETHER, AND APPLICATION FOR SYNTHESIS OF Ivabradine and its salt
MXPA05010771A (en) Process for the production of 9-cis retinoic acid.
MX2023000715A (en) Method for producing hypochlorous acid.

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 23746509

Country of ref document: EP

Kind code of ref document: A2

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)