CY1108469T1 - PROCEDURE FOR THE PRODUCTION OF GEMIFLOXAKIN ACID SALTS - Google Patents

PROCEDURE FOR THE PRODUCTION OF GEMIFLOXAKIN ACID SALTS

Info

Publication number
CY1108469T1
CY1108469T1 CY20081101234T CY081101234T CY1108469T1 CY 1108469 T1 CY1108469 T1 CY 1108469T1 CY 20081101234 T CY20081101234 T CY 20081101234T CY 081101234 T CY081101234 T CY 081101234T CY 1108469 T1 CY1108469 T1 CY 1108469T1
Authority
CY
Cyprus
Prior art keywords
acid salts
gemifloxakin
procedure
production
present
Prior art date
Application number
CY20081101234T
Other languages
Greek (el)
Inventor
Hoon Choi
Sang-Chul Choi
Do-Hyun Nam
Bo-Seung Choi
Of Korea Republic
Original Assignee
Lg Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Life Sciences Ltd filed Critical Lg Life Sciences Ltd
Publication of CY1108469T1 publication Critical patent/CY1108469T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με μια διαδικασία για την παρασκευή αλάτων με οξέα της Γεμιφλοξακίνης, ενός αντιβιοτικού παράγοντα τύπου κινολόνης με ισχυρή αντιμικροβιακή δράση. Η διαδικασία σύμφωνα με την παρούσα εφεύρεση μπορεί να προσφέρει πλεονεκτήματα όπως απλότητα της διαδικασίας, βελτίωση της παραγωγικότητας και αύξηση της απόδοσης και τα παρόμοια, μέσω σύμπτυξης της συμβατικής σύνθεσης τριών σταδίων σε διαδικασία δύο σταδίων.The present invention relates to a process for the preparation of acid salts of Gemifloxacin, a quinolone-type antibiotic with strong antimicrobial activity. The process according to the present invention can provide advantages such as process simplicity, improved productivity and performance enhancement, and the like, by collapsing the conventional three-step synthesis into a two-step process.

CY20081101234T 2002-04-08 2008-10-31 PROCEDURE FOR THE PRODUCTION OF GEMIFLOXAKIN ACID SALTS CY1108469T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2002-0018847A KR100517638B1 (en) 2002-04-08 2002-04-08 New process for preparing acid salts of Gemifloxacin
EP03715805A EP1497290B1 (en) 2002-04-08 2003-04-04 Process for preparing acid salts of gemifloxacin

Publications (1)

Publication Number Publication Date
CY1108469T1 true CY1108469T1 (en) 2014-04-09

Family

ID=36241771

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081101234T CY1108469T1 (en) 2002-04-08 2008-10-31 PROCEDURE FOR THE PRODUCTION OF GEMIFLOXAKIN ACID SALTS

Country Status (32)

Country Link
US (1) US7361762B2 (en)
EP (1) EP1497290B1 (en)
JP (1) JP4315815B2 (en)
KR (1) KR100517638B1 (en)
CN (1) CN1291987C (en)
AP (1) AP1786A (en)
AT (1) ATE404559T1 (en)
AU (1) AU2003219581B2 (en)
BR (1) BRPI0309037B8 (en)
CA (1) CA2481217C (en)
CO (1) CO5611198A2 (en)
CY (1) CY1108469T1 (en)
DE (1) DE60322872D1 (en)
DK (1) DK1497290T3 (en)
EA (1) EA007222B1 (en)
ES (1) ES2311694T3 (en)
GE (1) GEP20074025B (en)
HK (1) HK1074440A1 (en)
HR (1) HRP20040929B1 (en)
IL (1) IL164328A (en)
IS (1) IS2731B (en)
MA (1) MA26408A1 (en)
MX (1) MXPA04009777A (en)
NO (1) NO330042B1 (en)
NZ (1) NZ536174A (en)
OA (1) OA12801A (en)
PL (1) PL372815A1 (en)
PT (1) PT1497290E (en)
SI (1) SI1497290T1 (en)
UA (1) UA77070C2 (en)
WO (1) WO2003087100A1 (en)
ZA (1) ZA200408088B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1412078T3 (en) * 2001-08-02 2009-02-02 Lg Life Sciences Ltd Process for the preparation of amino-protected derivatives of 4-aminomethylene-pyrrolidin-3-one, Gemifloxacin or its salts
WO2006134431A1 (en) * 2005-05-03 2006-12-21 Ranbaxy Laboratories Limited Formate salt of gemifloxacin
EP1891037A1 (en) * 2005-06-15 2008-02-27 Hetero Drugs Limited Gemifloxacin process and polymorphs
ZA200807674B (en) * 2006-03-07 2009-11-25 Wockhardt Ltd Prodrugs of benzoquinolizine-2-carboxylic acid
WO2008053324A1 (en) * 2006-10-31 2008-05-08 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of gemifloxacin mesylate

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57134482A (en) 1981-02-13 1982-08-19 Dainippon Pharmaceut Co Ltd 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8- naphthyridine-3-carboxylic acid-3/2 hydrate and its preparation
IN162769B (en) 1984-11-13 1988-07-09 Kyorin Seiyaku Kk
NZ222047A (en) 1986-10-08 1991-01-29 Bristol Myers Co Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents
JPH01100165A (en) 1987-10-13 1989-04-18 Shionogi & Co Ltd Oxime or hydroxylamine derivative based antimicrobial agent
US4920120A (en) 1988-01-25 1990-04-24 Warner-Lambert Company Antibacterial agents
JPH0356479A (en) 1989-07-24 1991-03-12 Takeshi Yokota P-toluenesulfonate of water-soluble quinolone derivative
IE66202B1 (en) 1989-08-16 1995-12-13 Pfizer Azabicyclo quinolone carboxylic acids
US5137892A (en) 1990-12-12 1992-08-11 Abbott Laboratories Quinoline, naphthyridine and pyridobenzoxazine derivatives
US5276041A (en) 1991-11-08 1994-01-04 Kaken Pharmaceutical Co., Ltd. Oxime derivatives
JPH0673056A (en) 1992-08-26 1994-03-15 Kaken Pharmaceut Co Ltd Quinolinecarboxylic acid derivative and salt thereof
DE69509442T2 (en) * 1994-06-16 1999-09-02 Lg Chemical Ltd. Quinoline carboxylic acid derivatives with 7- (4-amino-methyl-3-oxime) pyrrolidine substituents and process for their preparation
US5776944A (en) 1994-06-16 1998-07-07 Lg Chemical Ltd. 7-(4-aminomethyl-3-methyloxyiminopyrroplidin-1-yl)-1-cyclopropyl-6-flu oro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid and the process for the preparation thereof
JP3449658B2 (en) 1994-12-21 2003-09-22 杏林製薬株式会社 8-Alkoxyquinolonecarboxylic acid hydrate excellent in stability and method for producing the same
ES2117426T3 (en) 1995-06-06 1998-08-01 Pfizer CRYSTALLINE FORM OF ANHYDRAUS SALT COMPOSED OF ACIDS 7 - ((1A, 5A, 6A) -6-AMINO-3-AZABICICLO (3.1.0.) HEX-3-IL) -6-FLUORO-1- (2, 4-DIFLUOROFENIL) -1,4-DIHIDRO-4-OXO-1,8-NAFTIRIDINA-3-CARBOXILICO AND METANOSULFONICO.
RO120134B1 (en) 1995-08-11 2005-09-30 Pfizer Inc. (1s, 2s)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol methane sulphonate trihydrate and pharmaceutical composition
ATE239723T1 (en) 1996-03-29 2003-05-15 Smithkline Beecham Corp EPROSARTANE DIHYDRATE AND A METHOD FOR THE PRODUCTION AND FORMULATION THEREOF
MA24500A1 (en) * 1997-03-21 1998-10-01 Lg Life Sciences Ltd CARBOXYLIC ACID SALT DERIVATIVE FROM NAPHTHYRIDINE.
KR100286874B1 (en) 1998-03-04 2001-04-16 성재갑 Method for preparing protected 4-aminomethyl-pyrrolidone-3-on
AU4211799A (en) 1998-05-29 1999-12-13 Pharmacia & Upjohn Company 3-[(1--n-methylamino)ethyl-n-benzyl] pyrrolidine monomethanesulfonate
GB9820405D0 (en) 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
JP2003531101A (en) 1999-06-29 2003-10-21 スミスクライン・ビーチャム・コーポレイション Use of fluoroquinolones for bacteria
EP1401440A4 (en) 1999-09-01 2006-07-05 Lg Life Sciences Ltd Methods of use of fluoroquinolone compounds against bacteria
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
EP1561465A3 (en) 1999-09-22 2005-12-21 LG Life Sciences, Ltd. Methods of use of fluoroquinolone compounds against bacteria
KR20010091379A (en) 2000-03-15 2001-10-23 성재갑 Novel process for the preparation of quinoline carboxylic acid derivatives having 7-(4-aminomethyl-3-oxime)pyrrolidine substituent
KR20020018560A (en) 2000-09-01 2002-03-08 성재갑 Novel process for preparing 3-aminomethyl-4-Z-methoxyiminopyrrolidine

Also Published As

Publication number Publication date
AU2003219581A1 (en) 2003-10-27
MA26408A1 (en) 2004-12-01
JP2005529112A (en) 2005-09-29
IS7477A (en) 2004-09-30
HRP20040929A2 (en) 2005-02-28
SI1497290T1 (en) 2008-12-31
NZ536174A (en) 2006-09-29
MXPA04009777A (en) 2004-12-13
CN1649868A (en) 2005-08-03
OA12801A (en) 2006-07-11
WO2003087100A1 (en) 2003-10-23
PT1497290E (en) 2008-11-14
EP1497290A4 (en) 2006-05-10
NO330042B1 (en) 2011-02-07
ES2311694T3 (en) 2009-02-16
BR0309037A (en) 2005-02-01
IL164328A (en) 2009-08-03
KR100517638B1 (en) 2005-09-28
CO5611198A2 (en) 2006-02-28
DE60322872D1 (en) 2008-09-25
EA200401328A1 (en) 2005-06-30
AP1786A (en) 2007-10-04
NO20044629L (en) 2004-10-27
AU2003219581B2 (en) 2006-08-24
CN1291987C (en) 2006-12-27
BRPI0309037B8 (en) 2021-05-25
GEP20074025B (en) 2007-01-25
EP1497290B1 (en) 2008-08-13
DK1497290T3 (en) 2008-12-15
HK1074440A1 (en) 2005-11-11
IS2731B (en) 2011-04-15
ATE404559T1 (en) 2008-08-15
EP1497290A1 (en) 2005-01-19
IL164328A0 (en) 2005-12-18
PL372815A1 (en) 2005-08-08
BRPI0309037B1 (en) 2018-07-31
AP2004003148A0 (en) 2004-12-31
JP4315815B2 (en) 2009-08-19
EA007222B1 (en) 2006-08-25
ZA200408088B (en) 2006-05-31
US7361762B2 (en) 2008-04-22
HRP20040929B1 (en) 2013-12-06
UA77070C2 (en) 2006-10-16
KR20030080292A (en) 2003-10-17
US20050148622A1 (en) 2005-07-07
CA2481217C (en) 2010-06-01
CA2481217A1 (en) 2003-10-23

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