WO2023128963A1 - Skin product comprising anthemis rosea subsp. carnea (boiss.) grierson extract - Google Patents

Skin product comprising anthemis rosea subsp. carnea (boiss.) grierson extract Download PDF

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Publication number
WO2023128963A1
WO2023128963A1 PCT/TR2022/050726 TR2022050726W WO2023128963A1 WO 2023128963 A1 WO2023128963 A1 WO 2023128963A1 TR 2022050726 W TR2022050726 W TR 2022050726W WO 2023128963 A1 WO2023128963 A1 WO 2023128963A1
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WO
WIPO (PCT)
Prior art keywords
skin
extract
carnea
anthemis
skin product
Prior art date
Application number
PCT/TR2022/050726
Other languages
French (fr)
Inventor
Urun Kandemirer
Kevser Özgen Özer
Evren Homan Gökçe
Sakine TUNCAY TANRIVERDİ
Şura BAYKAN ÖZTÜRK
Original Assignee
Eczacibasi Tuketim Urunleri Sanayi Ve Ticaret Anonim Sirketi
Ege Universitesi Idari Ve Mali Isler Daire Baskanligi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from TR2021/021367 external-priority patent/TR2021021367A1/en
Application filed by Eczacibasi Tuketim Urunleri Sanayi Ve Ticaret Anonim Sirketi, Ege Universitesi Idari Ve Mali Isler Daire Baskanligi filed Critical Eczacibasi Tuketim Urunleri Sanayi Ve Ticaret Anonim Sirketi
Publication of WO2023128963A1 publication Critical patent/WO2023128963A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/524—Preservatives

Definitions

  • the subject of the invention relates to a skin product comprising the extract of the plant Anthemis rosea subsp. carnea (Boiss.) Grierson, which inhibits the growth of pathogenic microorganisms in the product where it is added and which does not deteriorate the skin health owing to being natural.
  • the skin is an important part of the body, which protects the internal organs from the external mechanical, chemical and biological effects by separating the internal organs from the external environment, contains the natural moisturizing factors such as free amino acids, carboxylic acid, sugars, urea, ammonia, uric acid, keratin, calcium, magnesium, phosphate, citrate and chloride enabling the regulation of the water balance of the skin and the preservation of the elastic structure and natural flora of the skin by drawing from the atmosphere the water in a quantity that is 3-4 times their weight, and is capable of self-repair through the production of collagen and protein.
  • the natural moisturizing factors such as free amino acids, carboxylic acid, sugars, urea, ammonia, uric acid, keratin, calcium, magnesium, phosphate, citrate and chloride enabling the regulation of the water balance of the skin and the preservation of the elastic structure and natural flora of the skin by drawing from the atmosphere the water in a quantity that is 3-4 times their weight, and is
  • the natural structure of the skin may be disrupted.
  • the disinfectants which are applied to the skin in order to eliminate the pathogenic microorganisms, and/or the dry air cause/s the reduction of the natural moisturizing factors in the skin, and thus, the reduction of the water content of the skin and the reduction of the production of the lipids with skin moisturizing action.
  • the loss of water causes the dry skin and the itching, exfoliation and cracking develop in the dry skin.
  • the disruption of the moisture balance of the skin the number of the beneficial microorganisms in the skin flora decreases, the balance of the flora becomes disrupted and the infections develop in the skin.
  • the skin products with at least one of the properties of moisturizing, soothing, repair, firming and the like are used for the purpose of preserving the natural structure of the skin.
  • These products comprise the antimicrobial preservatives intended to inhibit the growth of the pathogenic microorganisms such as mold, yeast and bacteria, which would impair the activity of the product.
  • the skin products used in the state of the art comprise the synthetic and/or semi-synthetic antimicrobial preservatives.
  • Such preservatives have the cell viability-reducing effects and the carcinogenic effects.
  • the conventional skin products comprise, in addition to the antimicrobial preservatives, a separate natural or synthetic or semi-synthetic skin care agent for each action desired so that said products may provide the additional actions such as moisturizing the skin, repairing the skin by enhancing cell viability, and firming the skin.
  • a separate natural or synthetic or semi-synthetic skin care agent for each action desired so that said products may provide the additional actions such as moisturizing the skin, repairing the skin by enhancing cell viability, and firming the skin.
  • the skin products are needed, comprising a natural agent, which inhibits the growth of the pathogenic microorganisms in the skin care products without deteriorating the skin health and which even strengthens the skin with more than one action it provides.
  • a skin product comprising the extract of the plant Anthemis rosea subsp. carnea, a plant endemic to the Mediterranean Region of our country, which inhibits, owing to its antimicrobial property, the growth of the pathogenic microorganisms in the product and thus enables the product to exhibit long-lasting action, does not damage the skin, and even further, strengthens the skin owing to its antioxidant/cell viability-enhancing/repair properties in addition to the antimicrobial property, has been developed within the scope of the invention. It thus becomes possible to obtain a product, which provides multiple actions owing to the single agent it comprises, and to confer each of said actions simultaneously to the skin via the use of a single product.
  • An object of the invention is to develop a skin- and environment-friendly skin product, which comprises the natural Anthemis rosea subsp. carnea extract, is free of synthetic or semi-synthetic preservatives and does not deteriorate the skin health while inhibiting the growth of the pathogenic microorganisms.
  • Another object of the invention is to develop a skin product, via which all of the antioxidant/cell viability-enhancing/repair actions, in addition to the antimicrobial action, are achieved with a single ingredient.
  • Another object of the invention is to develop an economical skin product, which, as a single product, provides multiple benefits to the skin and thus eliminates the consumers' requirement to use more than product.
  • Another object of the invention is to enable the natural Anthemis rosea subsp. carnea plant with antimicrobial, antioxidant, cell viability-enhancing and skin-strengthening actions to be used in the skin products and thus provide a new field of use for the Anthemis rosea subsp. carnea plant.
  • the subject of the invention relates to a skin product comprising the extract of the plant Anthemis rosea subsp. carnea, which inhibits the growth of pathogenic microorganisms in the product where it is added and which does not deteriorate the skin health owing to being natural.
  • the skin product according to the invention may comprise the extract, juice (hydrolate) or essential oil of the capitula of the flowers of the plant Anthemis rosea subsp. carnea, or mixtures of these, as the extract of said plant.
  • the extract of the plant Anthemis rosea subsp. carnea may be obtained preferably by the use of the methods of distillation and/or extraction.
  • the skin product according to the invention comprises the extract of the plant Anthemis rosea subsp. carnea preferably at a ratio of 0.01-3% by weight.
  • the skin product comprising the extract of the plant Anthemis rosea subsp. carnea at the mentioned ratios does not reduce the cell viability and even increases the cell viability compared to the level prior to application, contrary to the reference products, which do not comprise preservatives or comprise synthetic and/or semi-synthetic preservatives.
  • the skin product according to the invention comprises the extract of the plant Anthemis rosea subsp. carnea preferably at a ratio of 0.1-2% by weight.
  • the skin product according to the invention may comprise at least one type of fixed oil in addition to the extract of the plant Anthemis rosea subsp. carnea.
  • the skin product according to the invention may comprise at least one emulsifier in addition to the extract of the plant Anthemis rosea subsp. carnea.
  • the skin product according to the invention may comprise at least one surfactant in addition to the extract of the plant Anthemis rosea subsp. carnea.
  • the skin product according to the invention may comprise at least one skin care agent in addition to the extract of the plant Anthemis rosea subsp. carnea.
  • the skin care agent/s may be selected from, but are not limited to, the agents moisturizing the skin and/or repairing the skin and/or tightening the skin and/or regulating the skin flora, preferably from the polyhydric alcohols such as glycerin, propylene glycol, pentylene glycol and caprylyl glycol, or the vitamins such as retinol (vitamin A), riboflavin (vitamin B2), niacinamide (vitamin B3), panthenol (provitamin B5), biotin, folic acid and tocopheryl acetate (vitamin E), or the extracts such as bisabolol, allantoin, lanolin, urea, sodium hyaluronate, PEG-75 lanolin, sodium lactate, sodium glucon
  • the skin product according to the invention may comprise water in addition to the extract of the plant Anthemis rosea subsp. carnea.
  • the skin product according to the invention is preferably a cosmetic product.
  • the disclosed skin product does not allow the growth pathogenic microorganisms and thus exhibits long-lasting action, causes no deterioration in the skin health, and even prevents the skin irritation and enables the repair and strengthening of the skin by enhancing the cell viability.
  • all these functions are achieved by more than one agent in the conventional skin products, they are achieved only by the extract of the plant Anthemis rosea subsp. carnea in the product according to the invention.
  • the production and the use of the skin products comprising the extract of the plant Anthemis rosea subsp. carnea become more economical for the manufacturers and the consumers, compared to the conventional skin products.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The subject of the invention relates to a skin product comprising the extract of the plant Anthemis rosea subsp. carnea, which inhibits the growth of pathogenic microorganisms in the product where it is added and which does not deteriorate the skin health owing to being natural. The extract, juice (hydrolate) or essential oil obtained from the capitula of the flowers of the plant Anthemis rosea subsp. carnea, or mixtures of these, may be used as the extract of said plant. The extract of the plant Anthemis rosea subsp. carnea, owing to having the antioxidant property in addition to being natural and having the antimicrobial property, enhances the cell viability and provides the skin care. Owing to comprising said extract with multiple actions, the skin product alone provides multiple benefits to the skin by means of a single agent.

Description

SKIN PRODUCT COMPRISING ANTHEMIS ROSEA SUBSP. CARNEA (BOISS.) GRIERSON
EXTRACT
Subject of the Invention
The subject of the invention relates to a skin product comprising the extract of the plant Anthemis rosea subsp. carnea (Boiss.) Grierson, which inhibits the growth of pathogenic microorganisms in the product where it is added and which does not deteriorate the skin health owing to being natural.
State of the Art
The skin is an important part of the body, which protects the internal organs from the external mechanical, chemical and biological effects by separating the internal organs from the external environment, contains the natural moisturizing factors such as free amino acids, carboxylic acid, sugars, urea, ammonia, uric acid, keratin, calcium, magnesium, phosphate, citrate and chloride enabling the regulation of the water balance of the skin and the preservation of the elastic structure and natural flora of the skin by drawing from the atmosphere the water in a quantity that is 3-4 times their weight, and is capable of self-repair through the production of collagen and protein.
Due to the continuous contact during a day with many surfaces on which pathogenic microorganisms accumulate, with air and with water, the natural structure of the skin may be disrupted. The disinfectants, which are applied to the skin in order to eliminate the pathogenic microorganisms, and/or the dry air cause/s the reduction of the natural moisturizing factors in the skin, and thus, the reduction of the water content of the skin and the reduction of the production of the lipids with skin moisturizing action. The loss of water causes the dry skin and the itching, exfoliation and cracking develop in the dry skin. Upon the disruption of the moisture balance of the skin, the number of the beneficial microorganisms in the skin flora decreases, the balance of the flora becomes disrupted and the infections develop in the skin.
The skin products with at least one of the properties of moisturizing, soothing, repair, firming and the like are used for the purpose of preserving the natural structure of the skin. These products comprise the antimicrobial preservatives intended to inhibit the growth of the pathogenic microorganisms such as mold, yeast and bacteria, which would impair the activity of the product. The skin products used in the state of the art comprise the synthetic and/or semi-synthetic antimicrobial preservatives. Such preservatives have the cell viability-reducing effects and the carcinogenic effects. Thus, contrary to the expectation that they would support, repair and strengthen the skin, the skin products, since they contain such preservatives, lead to the loss of skin cells and to the disruption of the natural flora and moisture balance of the skin, i.e. the structure of the skin, especially when applied to the sensitive and vulnerable skin. Moreover, the conventional skin products comprise, in addition to the antimicrobial preservatives, a separate natural or synthetic or semi-synthetic skin care agent for each action desired so that said products may provide the additional actions such as moisturizing the skin, repairing the skin by enhancing cell viability, and firming the skin. This causes an increase in the production costs and in the product costs. Consequently, the skin products are needed, comprising a natural agent, which inhibits the growth of the pathogenic microorganisms in the skin care products without deteriorating the skin health and which even strengthens the skin with more than one action it provides.
In order to meet the mentioned need, a skin product comprising the extract of the plant Anthemis rosea subsp. carnea, a plant endemic to the Mediterranean Region of our country, which inhibits, owing to its antimicrobial property, the growth of the pathogenic microorganisms in the product and thus enables the product to exhibit long-lasting action, does not damage the skin, and even further, strengthens the skin owing to its antioxidant/cell viability-enhancing/repair properties in addition to the antimicrobial property, has been developed within the scope of the invention. It thus becomes possible to obtain a product, which provides multiple actions owing to the single agent it comprises, and to confer each of said actions simultaneously to the skin via the use of a single product. Owing to the natural fragrance of the plant extract, there is no need to use a separate essence. As a result, the production and the use of the skin products comprising the extract of the plant Anthemis rosea subsp. carnea become more economical for the manufacturers and the consumers, compared to the conventional skin products.
Object of the Invention
An object of the invention is to develop a skin- and environment-friendly skin product, which comprises the natural Anthemis rosea subsp. carnea extract, is free of synthetic or semi-synthetic preservatives and does not deteriorate the skin health while inhibiting the growth of the pathogenic microorganisms.
Another object of the invention is to develop a skin product, via which all of the antioxidant/cell viability-enhancing/repair actions, in addition to the antimicrobial action, are achieved with a single ingredient.
Another object of the invention is to develop an economical skin product, which, as a single product, provides multiple benefits to the skin and thus eliminates the consumers' requirement to use more than product.
Another object of the invention is to enable the natural Anthemis rosea subsp. carnea plant with antimicrobial, antioxidant, cell viability-enhancing and skin-strengthening actions to be used in the skin products and thus provide a new field of use for the Anthemis rosea subsp. carnea plant.
Description of the Invention
The subject of the invention relates to a skin product comprising the extract of the plant Anthemis rosea subsp. carnea, which inhibits the growth of pathogenic microorganisms in the product where it is added and which does not deteriorate the skin health owing to being natural. The skin product according to the invention may comprise the extract, juice (hydrolate) or essential oil of the capitula of the flowers of the plant Anthemis rosea subsp. carnea, or mixtures of these, as the extract of said plant.
The extract of the plant Anthemis rosea subsp. carnea may be obtained preferably by the use of the methods of distillation and/or extraction.
The skin product according to the invention comprises the extract of the plant Anthemis rosea subsp. carnea preferably at a ratio of 0.01-3% by weight. At the clinical studies, it was concluded that the skin product comprising the extract of the plant Anthemis rosea subsp. carnea at the mentioned ratios does not reduce the cell viability and even increases the cell viability compared to the level prior to application, contrary to the reference products, which do not comprise preservatives or comprise synthetic and/or semi-synthetic preservatives.
The skin product according to the invention comprises the extract of the plant Anthemis rosea subsp. carnea preferably at a ratio of 0.1-2% by weight.
In some preferred embodiments, the skin product according to the invention may comprise at least one type of fixed oil in addition to the extract of the plant Anthemis rosea subsp. carnea.
In some preferred embodiments, the skin product according to the invention may comprise at least one emulsifier in addition to the extract of the plant Anthemis rosea subsp. carnea.
In some preferred embodiments, the skin product according to the invention may comprise at least one surfactant in addition to the extract of the plant Anthemis rosea subsp. carnea.
In some preferred embodiments, the skin product according to the invention may comprise at least one skin care agent in addition to the extract of the plant Anthemis rosea subsp. carnea. In said embodiments, the skin care agent/s may be selected from, but are not limited to, the agents moisturizing the skin and/or repairing the skin and/or tightening the skin and/or regulating the skin flora, preferably from the polyhydric alcohols such as glycerin, propylene glycol, pentylene glycol and caprylyl glycol, or the vitamins such as retinol (vitamin A), riboflavin (vitamin B2), niacinamide (vitamin B3), panthenol (provitamin B5), biotin, folic acid and tocopheryl acetate (vitamin E), or the extracts such as bisabolol, allantoin, lanolin, urea, sodium hyaluronate, PEG-75 lanolin, sodium lactate, sodium gluconate, sodium PCA, olive oil PEG-7 ester, saccharide isomerate, sugar leaf (stevia rebaudiana) extract, coconut (cocos nucifera) fruit extract and aloe barbadensis leaf extract, or the sugars such as fructose, maltose, glucose, sorbitol, maltodextrin, trehalose and lactose, or the proteins such as collagen, keratin and milk protein, or the probiotic-prebiotic additives such as bifida ferment lysate, alpha-glucan oligosaccharide, lactobacillus and inulin, or the amino acids available in the natural skin structure such as arginine, aspartic acid, glycine, alanine, serine, valine, proline, threonine, isoleucine, histidine and phenylalanine, or the skin softeners such as ethylhexyl palmitate, isopropyl myristate, isopropyl palmitate, caprylic/capric triglyceride and coco caprylate/caprate, or the silicones such as dimethicon, or the vegetable oils such as jojoba oil, almond oil and avocado oil, or the hydrocarbon oils such as vaseline, squalene, paraffin and mineral oil, or the fatty acids or the fatty alcohols or the esters or the peptides or the vegetable waxes or the phospholipids or the sterols.
In some preferred embodiments, the skin product according to the invention may comprise water in addition to the extract of the plant Anthemis rosea subsp. carnea.
The skin product according to the invention is preferably a cosmetic product.
Owing to the natural ingredient it contains, the disclosed skin product does not allow the growth pathogenic microorganisms and thus exhibits long-lasting action, causes no deterioration in the skin health, and even prevents the skin irritation and enables the repair and strengthening of the skin by enhancing the cell viability. Whereas all these functions are achieved by more than one agent in the conventional skin products, they are achieved only by the extract of the plant Anthemis rosea subsp. carnea in the product according to the invention. As a result, the production and the use of the skin products comprising the extract of the plant Anthemis rosea subsp. carnea become more economical for the manufacturers and the consumers, compared to the conventional skin products.

Claims

1. A skin product characterized in that the skin product comprises the extract of the plant Anthemis rosea subsp. carnea, which inhibits the growth of pathogenic microorganisms in the product and which does not deteriorate the skin health owing to being natural.
2. A skin product according to Claim 1 characterized in that the extract of the plant Anthemis rosea subsp. carnea is the extract, juice (hydrolate) or essential oil obtained from the capitula of the flowers of said plant, or mixtures of these.
3. A skin product according to Claim 1 or Claim 2 characterized in that the extract of the plant Anthemis rosea subsp. carnea is obtained via distillation and/or extraction.
4. A skin product according to any one of Claims 1-3 characterized in that the skin product comprises the extract of the plant Anthemis rosea subsp. carnea at a ratio of 0.01-3% by weight.
5. A skin product according to any one of Claims 1-3 characterized in that the skin product comprises the extract of the plant Anthemis rosea subsp. carnea at a ratio of 0.1-2% by weight.
6. A skin product according to any one of the preceding claims characterized in that the skin product comprises at least one type of fixed oil.
7. A skin product according to any one of the preceding claims characterized in that the skin product comprises at least one emulsifier.
8. A skin product according to any one of the preceding claims characterized in that the skin product comprises at least one surfactant.
9. A skin product according to any one of the preceding claims characterized in that the skin product comprises at least one skin care agent.
10. A skin product according to any one of the preceding claims characterized in that the skin product comprises water.
6
11. A skin product according to any one of the preceding claims characterized in that the skin product is a cosmetic product.
7
PCT/TR2022/050726 2021-12-28 2022-07-07 Skin product comprising anthemis rosea subsp. carnea (boiss.) grierson extract WO2023128963A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2021021367 2021-12-28
TR2021/021367 TR2021021367A1 (en) 2021-12-28 SKIN PRODUCT CONTAINING ROSE CHAMOMILE EXTRACT

Publications (1)

Publication Number Publication Date
WO2023128963A1 true WO2023128963A1 (en) 2023-07-06

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Application Number Title Priority Date Filing Date
PCT/TR2022/050726 WO2023128963A1 (en) 2021-12-28 2022-07-07 Skin product comprising anthemis rosea subsp. carnea (boiss.) grierson extract

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WO (1) WO2023128963A1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000044419A (en) * 1998-07-27 2000-02-15 Noevir Co Ltd Antimicrobial plant extract and skin preparation for external use containing the same
KR101465972B1 (en) * 2013-03-29 2014-11-28 제주대학교 산학협력단 Composition for renewing skin containing vacuum-distillated chamomile extract as effective component
JP2020100570A (en) * 2018-12-20 2020-07-02 株式会社ノエビア Skin external preparation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000044419A (en) * 1998-07-27 2000-02-15 Noevir Co Ltd Antimicrobial plant extract and skin preparation for external use containing the same
KR101465972B1 (en) * 2013-03-29 2014-11-28 제주대학교 산학협력단 Composition for renewing skin containing vacuum-distillated chamomile extract as effective component
JP2020100570A (en) * 2018-12-20 2020-07-02 株式会社ノエビア Skin external preparation

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