WO2023126026A3 - Epa-ee纳米脂质组合物、及其制剂、制备方法和应用 - Google Patents
Epa-ee纳米脂质组合物、及其制剂、制备方法和应用 Download PDFInfo
- Publication number
- WO2023126026A3 WO2023126026A3 PCT/CN2023/078639 CN2023078639W WO2023126026A3 WO 2023126026 A3 WO2023126026 A3 WO 2023126026A3 CN 2023078639 W CN2023078639 W CN 2023078639W WO 2023126026 A3 WO2023126026 A3 WO 2023126026A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- epa
- nanocomposite
- lipid
- formulation
- preparation
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title abstract 3
- 150000002632 lipids Chemical class 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000002114 nanocomposite Substances 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000003995 emulsifying agent Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Mycology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
EPA-EE纳米脂质组合物、及其制剂、制备方法和应用。该EPA-EE纳米脂质组合物以具有高含量EPA-EE的原料为主要成分,且乳化剂中含有高不饱和磷脂,可制成纳米级别的亚微乳,用作口服制剂。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202111640995.4A CN116407543A (zh) | 2021-12-29 | 2021-12-29 | Epa-ee纳米脂质组合物、及其制剂、制备方法和应用 |
CN202111640995.4 | 2021-12-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2023126026A2 WO2023126026A2 (zh) | 2023-07-06 |
WO2023126026A3 true WO2023126026A3 (zh) | 2023-08-24 |
Family
ID=86998238
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CN2023/078639 WO2023126026A2 (zh) | 2021-12-29 | 2023-02-28 | Epa-ee纳米脂质组合物、及其制剂、制备方法和应用 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN116407543A (zh) |
WO (1) | WO2023126026A2 (zh) |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120065264A1 (en) * | 2009-05-22 | 2012-03-15 | Hirosato Fujii | SELF-EMULSIFYING COMPOSITION OF w3 FATTY ACID |
CN102421422A (zh) * | 2009-03-09 | 2012-04-18 | 普罗诺瓦生物医药挪威公司 | 含有脂肪酸油混合物和表面活性剂的组合物及其方法和用途 |
WO2014095628A1 (en) * | 2012-12-17 | 2014-06-26 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Oral formulation containing a statin in omega-3 polyunsaturated fatty acids (n-3 pufa) |
CN104739763A (zh) * | 2013-12-31 | 2015-07-01 | 中国科学院上海药物研究所 | 一种具有抗炎和抗血栓形成作用的静脉注射用脂肪乳剂及其制备方法和用途 |
CN105530927A (zh) * | 2013-07-18 | 2016-04-27 | 持田制药株式会社 | ω-3脂肪酸的自乳化组合物 |
CN105939706A (zh) * | 2014-01-28 | 2016-09-14 | 费森尤斯卡比德国有限公司 | 用于肠胃外给药的包含epa乙酯和dha乙酯的组合物 |
CN110636863A (zh) * | 2017-05-18 | 2019-12-31 | 丘比株式会社 | 具有自乳化性的组合物及其制造方法及纳米乳液及其制造方法 |
CN113116811A (zh) * | 2020-01-14 | 2021-07-16 | 中国科学院上海药物研究所 | 可注射长效镇痛药物组合物及其制备方法和用途 |
WO2021156385A1 (en) * | 2020-02-04 | 2021-08-12 | Wellness Holding B.V. | Lipid composition comprising omega-3 fatty acids |
-
2021
- 2021-12-29 CN CN202111640995.4A patent/CN116407543A/zh active Pending
-
2023
- 2023-02-28 WO PCT/CN2023/078639 patent/WO2023126026A2/zh unknown
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102421422A (zh) * | 2009-03-09 | 2012-04-18 | 普罗诺瓦生物医药挪威公司 | 含有脂肪酸油混合物和表面活性剂的组合物及其方法和用途 |
US20120065264A1 (en) * | 2009-05-22 | 2012-03-15 | Hirosato Fujii | SELF-EMULSIFYING COMPOSITION OF w3 FATTY ACID |
WO2014095628A1 (en) * | 2012-12-17 | 2014-06-26 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Oral formulation containing a statin in omega-3 polyunsaturated fatty acids (n-3 pufa) |
CN105530927A (zh) * | 2013-07-18 | 2016-04-27 | 持田制药株式会社 | ω-3脂肪酸的自乳化组合物 |
CN104739763A (zh) * | 2013-12-31 | 2015-07-01 | 中国科学院上海药物研究所 | 一种具有抗炎和抗血栓形成作用的静脉注射用脂肪乳剂及其制备方法和用途 |
CN105939706A (zh) * | 2014-01-28 | 2016-09-14 | 费森尤斯卡比德国有限公司 | 用于肠胃外给药的包含epa乙酯和dha乙酯的组合物 |
CN110636863A (zh) * | 2017-05-18 | 2019-12-31 | 丘比株式会社 | 具有自乳化性的组合物及其制造方法及纳米乳液及其制造方法 |
CN113116811A (zh) * | 2020-01-14 | 2021-07-16 | 中国科学院上海药物研究所 | 可注射长效镇痛药物组合物及其制备方法和用途 |
WO2021156385A1 (en) * | 2020-02-04 | 2021-08-12 | Wellness Holding B.V. | Lipid composition comprising omega-3 fatty acids |
Also Published As
Publication number | Publication date |
---|---|
CN116407543A (zh) | 2023-07-11 |
WO2023126026A2 (zh) | 2023-07-06 |
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