WO2023109979A3 - 一种展示新冠s蛋白的融合蛋白和重组病毒粒子及其应用 - Google Patents

一种展示新冠s蛋白的融合蛋白和重组病毒粒子及其应用 Download PDF

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WO2023109979A3
WO2023109979A3 PCT/CN2023/076443 CN2023076443W WO2023109979A3 WO 2023109979 A3 WO2023109979 A3 WO 2023109979A3 CN 2023076443 W CN2023076443 W CN 2023076443W WO 2023109979 A3 WO2023109979 A3 WO 2023109979A3
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protein
cov
sars
fusion protein
fusion
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WO2023109979A2 (zh
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陈瑞婷
孙慧敏
毛水花
周孟云
宋家升
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浙江迪福润丝生物科技有限公司
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Abstract

提供了一种展示新冠S蛋白的融合蛋白和重组病毒粒子及其应用，属于生物制品技术领域。提供了一种表达新冠S蛋白的融合基因及融合蛋白，该融合基因或融合蛋白包含新冠S蛋白的胞外结构域序列与禽副黏病毒科F蛋白的跨膜结构域和胞内结构域序列。同时，含有该序列的重组NDV病毒具有较强的中和抗体的能力。可见，S蛋白的胞外域编码序列和APMV病毒科病毒(除NDV外)F蛋白的跨膜结构域和胞内结构域编码序列相融合所产生的融合基因或蛋白，具有成为优秀新冠疫苗候选抗原的巨大潜力。
PCT/CN2023/076443 2021-12-16 2023-02-16 一种展示新冠s蛋白的融合蛋白和重组病毒粒子及其应用 WO2023109979A2 (zh)

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CN117247463A (zh) * 2021-12-16 2023-12-19 浙江迪福润丝生物科技有限公司 一种展示新冠病毒s蛋白的融合蛋白和重组病毒粒子及其应用

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WO2021206581A1 (en) * 2020-04-05 2021-10-14 Dukhovlinov Ilya Vladimirovich Genetic construct-based vaccine against coronavirus infection
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WO2021226348A2 (en) * 2020-05-07 2021-11-11 Icahn School Of Medicine At Mount Sinai Recombinant newcastle disease virus expressing sars-cov-2 spike protein and uses thereof
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