WO2023106810A1 - Oral composition comprising co-precipitate for promoting tooth whitening - Google Patents

Abstract

The present invention provides an oral composition, comprising a coprecipitate formed by at least two metal salts as an activator of peroxide, for promoting, improving, or enhancing tooth whitening, and the composition can exhibit excellent enzymatic activity in a high-pH condition ranging in pH from 6 to 14. In addition, the present invention provides a kit comprising the composition for tooth whitening and a method for preparing the oral composition.

Description

Oral composition for promoting tooth whitening comprising a coprecipitate

This application claims priority based on Korean Patent Application No. 10-2021-0177090 filed on December 10, 2021, and all contents disclosed in the specification and drawings of the application are incorporated into this application. The present invention relates to a composition for promoting, improving, or enhancing tooth whitening, and more particularly, to a composition for promoting, improving, or enhancing tooth whitening comprising a coprecipitate.

In the case of domestic tooth whitening products, the concentration of the active ingredient (hydrogen peroxide) is limited to a maximum of 3% according to the Pharmaceutical Affairs Act. This is considerably lower than that of overseas products (up to 10% in the case of Crest 3D White Whitestrips), and it takes a long time to experience a recognizable tooth color change, causing inconvenience to consumers. Therefore, in the industry, products containing iron (Fe) ions are applied to the teeth to provide quick effects while maintaining the concentration of active ingredients that are legally limited, and then a strip containing active ingredients is attached thereon to increase the whitening effect. this is being provided. However, these products may have a problem in that the reaction rate slows down as the reaction of iron ions with hydrogen peroxide continues over time. In addition, in the case of the product, since an acidic environment deteriorates dental health, the pH of the product is designed to be more than neutral. In this environment, iron (Fe) ions form sludge and activity is reduced. Although iron sludge formation can be suppressed when a heterogeneous catalyst such as iron oxide is applied, the maximum activity of the reaction still comes under acidic conditions.

Therefore, the problem to be solved by the present invention is to apply a catalyst having high activity at a neutral or higher pH to a tooth whitening agent to effectively provide a desired whitening effect even when used for a short time. In addition, it is intended to provide a tooth whitening composition or kit capable of inducing tooth whitening while preventing dental caries due to low pH using high pH.

In order to solve the above problems, it is intended to provide an oral composition for accelerating, improving, or improving tooth whitening comprising a co-precipitate formed by at least two or more metal salts as an activator of peroxide. An oral composition comprising the active agent may have a pH ranging from 6 to 14.

Herein, promoting tooth whitening may be understood as accelerating the time for teeth to become white, and, for example, accelerating the decomposition rate of organic matter accumulated on the tooth surface. Improving tooth whitening can be understood as the activator of the peroxide helping to whiten the tooth whitening agent. The composition for improving tooth whitening may mean that the degree of tooth whitening is superior when the active agent is included compared to before it is included. It can be appreciated that the oral composition for promoting, improving, or enhancing tooth whitening assists the tooth whitening performance of a peroxide having a tooth whitening effect, particularly hydrogen peroxide, rather than being used as a tooth whitening agent per se.

A co-precipitate may be understood to mean a substance precipitated after dissolving two or more substances in a solvent. It may be a material obtained by removing the solvent containing the precipitate. The coprecipitate can be obtained by a coprecipitation method commonly used in the industry, and the preparation method of the coprecipitate is not particularly limited as long as the coprecipitate can be obtained under conditions having a pH in the range of 6 to 14.

The composition may be used without limitation as long as it can be applied to the tooth surface or come into contact with the tooth surface, including liquid, paste, patch, gum, gel formulation, etc. A gel formulation may be preferred considering the compatibility of the co-precipitate and the stability of the co-precipitate. For example, the composition is a gel having a viscosity of 2,000 to 50,000 cps, preferably 10,000 to 30,000 cps when measured with a Brookfield RV viscometer manufactured by Brookfield Engineering Laboratories, Inc. under conditions of No. 7 spindle, 20 rpm and 25 ° C. may be a formulation. The composition includes a coprecipitate, and the coprecipitate may be homogeneously or heterogeneously mixed without dissolving.

The composition for activating peroxide of the present invention can be used to activate the whitening effect of peroxide, which is one of the active ingredients for tooth whitening. The composition may be used as a catalyst for decomposition of peroxide, which is one of the components for tooth whitening, and preferably, the co-precipitate may be used as the catalyst.

In the present specification, 'peroxide activation' may mean that peroxide is present in the oral cavity or in a state capable of decomposing organic matter attached to the tooth surface, preferably in a radical state. Here, the radical state may include not only a hydroperoxyl radical (HO ₂ ), but also a hydroxyl radical (OH) formed by reacting the hydroperoxyl radical with hydrogen peroxide.

Preferably, the co-precipitate may include a copper-iron coprecipitate, and in particular, the inventors of the present invention use the co-precipitate of iron and copper as a catalyst to help decomposition or activity of a tooth whitening component to increase the whitening effect. I found out.

Another embodiment of the present invention is a copper precursor; And it is possible to provide an oral composition for promoting, improving, or improving tooth whitening including a copper-iron coprecipitate prepared by mixing a metal precursor containing an iron precursor in an environment having a pH in the range of 6 to 14. The copper-iron coprecipitate can be obtained in this environment, for example by mixing copper sulfate and ferric chloride. The copper-iron coprecipitate can be identified through an apparatus such as EDS (energy dispersive spectroscopy) or the like. The copper-iron coprecipitate is precipitated by mixing copper and iron with different elements. Here, the copper-iron coprecipitate may be formed by including additional elements in addition to copper and iron due to external factors, and the structure of the coprecipitate is particularly Not limited. For example, crystal forms, clathrates, and the like may also be included in the scope of the present invention.

When the coprecipitate is formed, the pH may be in the range of 6 to 14, preferably pH 8 or higher, and more preferably pH 9 to 12. In particular, in one embodiment of the present invention, as in the Fenton reaction mechanism of iron and copper schematized in FIG. It is intended to provide a composition capable of obtaining hyperhydrolysis efficiency and tooth whitening effect. In the organic matter decomposition process using the Fenton reaction, iron ions (Fe ²⁺ ) or copper ions (Cu ²⁺ ) act as catalysts to decompose hydrogen peroxide, and it is understood that the hydroxyl radicals ^generated at this time decompose organic matter. can The radical formation reaction using trivalent iron and hydrogen peroxide is also called a Fenton-like reaction. Fe reacts with water or generated oxygen species to repeat oxidation and reduction of Fe ^{2 +} ↔ Fe ^{3 +} , and this reaction occurs until hydrogen peroxide is completely consumed. A competitive reaction occurs between iron ions, organic matter, and hydrogen peroxide. In general, the reaction rate of divalent iron (Fe(II)) ions is fast and the reaction rate of trivalent iron (Fe(III)) ions is relatively slow. there is. In order to compensate for these disadvantages, iron ions are provided in the form of coprecipitates, and in particular, copper-iron coprecipitates have been provided. It is understood that when the coprecipitate reacts with hydrogen peroxide under basic conditions, since the coprecipitate is a heterogeneous catalyst, sludge formation can be prevented, and the reaction between iron and copper can occur better. The accumulation of trivalent iron due to the aforementioned difference in reaction rates between divalent iron and trivalent iron can be eliminated due to a reaction in which trivalent iron can be converted into divalent iron by monovalent copper. The Fenton reaction equation of iron and copper is already well known in the industry as shown in Table 1 below. Since the Fenton reaction of copper occurs well even under basic conditions, the overall reaction efficiency is increased, and it is judged that the reaction of copper again by ROS (reactive oxygen species) generated in the reaction is well suppressed through co-precipitation with iron.

No.	reaction formula	reaction rate constant
One	Cu 2 + + H 2 O 2 → Cu + + H + + HOO	4.9 * 10 2 M -1 s -1
2	Cu + + H 2 O 2 → Cu 2 + + HO - + HO	2.2 * 10 2 M -1 s -1
3	Fe 2 + + H 2 O 2 → Fe 3 + + HO - + HOㆍ	5.7 * 10 2 M -1 s -1
4	Fe 3 + + H 2 O 2 → Fe 2 + + H + + HOO	2.6 * 10 -3 M -1 s -1
5	Cu + + Fe 3 + → Cu 2 + + Fe 2 +	-

The composition containing the co-precipitate may be used as a catalyst for improving the tooth whitening effect of a tooth whitening composition containing a tooth whitening component, preferably peroxide, more preferably hydrogen peroxide. The composition may be pH 6 or higher, pH 7 or higher, pH 8 or higher, pH 9 or higher, pH 10 or higher, pH 11 or higher, pH 12 or higher, pH 13 or higher, or pH 14 or higher, preferably pH 6 to 14. range, or pH 7 to 13, or pH 8 to 12, or pH 9 to 11. When having the above pH range, coprecipitate of iron and copper can be stably formed, and a large amount of radicals are released even in a gel formulation, and the radicals to be released can be smoothly moved to the teeth. In particular, in the case of products containing tooth whitening ingredients, the pH is adjusted to a low pH (acidic condition) to stabilize fruit water to prevent decomposition of fruit water that may occur during distribution. A composition having the above pH range is applied to the tooth surface By doing so, it is possible to prevent acidification of the tooth surface, thereby preventing tooth abrasion or tooth corrosion. The composition may further include a thickening agent, and preferably, the thickening agent may include a thickening agent commonly used in the industry, for example, alginate, hydroxypropyl methylcellulose (HPMC), hydrogel Hydroxyethyl Cellulose (HEC), Methyl Cellulose, Carboxymethyl Cellulose (CMC), Gelatin, Collagen, Agar, Starch, Pectin, Polyvinyl Alcohol (Polyvinyl alcohol), hyaluronan, carbomer, acrylate copolymer (Eudragit™), shellac, and polyvinylpyrrolidone. Preferably, the thickener may include polyvinylpyrrolidone, and the polyvinylpyrrolidone is a polymer that has little effect on the reaction between the co-precipitate and the peroxide, and can effectively promote decomposition of organic matter. It is a preferred polymer that may not interfere with the release of radicals and their movement to teeth when the composition for whitening teeth is applied.

In addition to the thickener, the oral composition may further include a wetting agent, a sweetening agent, a pH adjusting agent, a preservative, a gum irritation reliever, a viscosity adjusting agent, and the like, components commonly used in the industry within a range that does not impair the object of the present invention can include without limitation. For example, the wetting agent may include one or more of glycerin, polyethylene glycol, polypropylene glycol, and the like, and may include 15 to 25% by weight based on the total weight of the composition. The sweetener may include one or more of saccharin, stevioside, xylitol, and the like, and may include 0.1 to 1% by weight based on the total weight of the composition. The pH adjusting agent may include at least one selected from the group consisting of sodium hydroxide, potassium hydroxide, sodium phosphate, disodium phosphate, trisodium phosphate, sodium pyrophosphate, and tribasic potassium phosphate, and the pH adjusting agent may contain the total amount of the composition. It can be added until the pH is 6 or more, 7 or more, 8 or more, 8.5 or more, 9 or more, 9.5 or more, 10 or more, 10.5 or more, 11 or more, 11.5 or more, 12 or more, or 13 or more, preferably the composition It may contain 2 to 10% by weight based on the total weight, and more preferably 3 to 8% by weight. The preservative may preferably include a natural preservative, and may not preferably include a chemical preservative. The gum irritation reliever may be used without limitation as long as it is a component known in the art as a component capable of reducing irritation caused by peroxide, and for example, amino acids including at least one of methionine, cysteine and taurine; organic acids including at least one of ursodeoxycholic acid and tauroursodeoxycholic acid; And it may include at least one selected from the group consisting of vitamins including at least one of vitamins A, C, and E. The gum irritation relief agent may contain 0.05 to 3% by weight, preferably 0.1 to 2.5% by weight, based on the total weight of the composition. The viscosity modifier may help the present composition to have a desired viscosity, and if the composition is prepared in a gel formulation, the viscosity modifier may prevent excessive stretching of the gel. Examples of the viscosity modifier may include at least one selected from the group consisting of colloidal silicon dioxide, magnesium stearate, and talc, and the viscosity modifier is 1 to 5% by weight, preferably 1.5 to 4% by weight, based on the total weight of the composition. % can be included. Another embodiment of the present invention may provide a tooth whitening kit including a first agent comprising the composition for activating the tooth whitening component, and a second agent comprising the tooth whitening composition comprising the tooth whitening component. . The first agent may have an environment having a pH range of 6 to 14, preferably a pH range of 9 to 11, and the peroxide included in the second agent is in an environment of pH 8 or higher created by application of the first agent. It can be activated to have a teeth whitening effect. Preferably, the tooth whitening component may include a peroxide, for example, hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium peroxide pyrophosphate, and sodium percarbonate may be any one or more selected from the group consisting of, preferably hydrogen peroxide can

The second agent may preferably be a tooth attachment patch, and the type or structure of the tooth attachment patch is not particularly limited, as long as the tooth whitening component containing peroxide is released to the tooth surface while being stored in the patch. can be used without For example, it is a multi-layer patch of two or more, a dry-type patch that is non-adhesive but becomes adhesive by moisture, or a patch that is completely hydrated in the oral cavity, or a drug layer is dissolved after use and a support layer It can be used without limitation within the range that does not impair the object of the present invention, such as a patch that removes. The patch may further include various components other than the tooth whitening component within a range that does not impair the purpose of the oral composition.

Another embodiment of the present invention includes a tooth whitening composition comprising a tooth whitening component after applying the first agent according to the present invention comprising a composition for activating a tooth whitening component to a tooth surface, and to the tooth surface to which the first agent is applied. It is possible to provide a tooth whitening method applying the second agent according to the present invention.

Another embodiment of the present invention is to apply the second agent according to the present invention comprising a tooth whitening composition containing a tooth whitening component to the tooth surface, and then to the tooth surface to which the second agent is applied, comprising a composition for activating a tooth whitening component It is possible to provide a tooth whitening method in which the first agent according to the present invention is applied to the tooth surface.

In another embodiment of the present invention, the first agent according to the present invention comprising a composition for activating a tooth whitening component and the second agent according to the present invention comprising a tooth whitening composition comprising a tooth whitening component are mixed immediately before use, It is possible to provide a tooth whitening method applied to the tooth surface.

Another embodiment of the present invention may provide a method for preparing an oral composition for promoting, improving, or enhancing tooth whitening, comprising a coprecipitate of two or more metal ions as a tooth whitening active agent. The manufacturing method is S1) a copper precursor; and preparing an aqueous solution of a metal precursor containing an iron precursor, S2) adding a pH adjusting agent to the aqueous solution so that the environment has a pH in the range of 6 to 14, preferably in the range of pH 9 to 11, S3) Forming a solution containing a copper-iron coprecipitate by mixing a pH adjusting agent, and optionally preparing a gel by adding a thickening agent to the solution of step S4) of step S3).

In the step S1), the precursor aqueous solution may contain a mixing ratio of the copper precursor and the iron precursor in a ratio of about 4:1 to 1:4, preferably in a weight ratio of 2:1 to 1:2. there is. When having the above mixing ratio, the tooth whitening effect may be excellent.

In step S2), the pH adjusting agent may include at least one selected from the group consisting of sodium hydroxide, potassium hydroxide, sodium phosphate, disodium phosphate, trisodium phosphate, sodium pyrophosphate, and tribasic potassium phosphate, Preferably, it may contain tribasic potassium phosphate, which is suitable for the purpose of the present invention and can also be expected to relieve irritation caused by peroxide.

The copper precursor and iron precursor may be derived from, for example, copper sulfate and ferric chloride, respectively, but copper and iron salts may be used without particular limitation as long as they can form copper ions and iron ions.

The pH adjusting agent is preferably added after each precursor is sufficiently dissolved in an ionic state in the solvent, and it may be preferable to add the pH adjusting agent after sufficiently melting considering the uniform formation of the coprecipitate.

In the step S3), the solution containing the copper-iron coprecipitate is preferably selected from the group consisting of tetrasodium pyrophosphate, sodium acid pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate, and acidic polyphosphate any one or more chelating agents; and/or polyacids including citric acid, tartaric acid, oxalic acid, succinic acid, or mixtures thereof, or salts thereof. Here, the salt may preferably include a sodium salt, a potassium salt, and the like. For example, the polyacid or salt thereof may include sodium citrate, sodium tartrate, sodium oxalate, potassium citrate, potassium tartrate, and the like. The component(s) may not be included for the purpose of evenly forming co-precipitates, enhancing tooth whitening efficacy, and the like. Here, not including may include substantially not including. Here, the meaning of substantially not including does not include at all or includes 0.1% by weight or less, 0.05% by weight or less, 0.03% by weight or less, 0.02% by weight or less, 0.01% by weight or less, preferably 0.009% by weight or less, based on the total weight of the composition. can mean doing

The composition disclosed herein may be stored and distributed in a container, and the container may be provided with an applicator that may be exemplified by a brush or a tip capable of applying the composition. If necessary, the application unit may be provided separately from the container. Instructions explaining how to use may be provided together with the container or the composition.

The present invention is a coprecipitate formed by at least two or more metal salts for use as an activator of peroxide in oral compositions having a pH range of 6 to 14. Alternatively, a method of using the coprecipitate may be provided.

The composition of the present invention does not decrease catalytic activity even at high pH (eg, pH 8 or higher), and can maintain catalytic activity even in a gel formulation, particularly at high pH.

In addition, by using a high pH, tooth whitening can be advantageously performed while preventing tooth irritation or damage caused by a low pH.

The following drawings attached to this specification illustrate preferred embodiments of the present invention, and serve to further understand the technical idea of the present invention together with the contents of the above-described invention, so the present invention is limited to those described in the drawings. It should not be construed as limiting.

1 is a result of confirming the amount of color change after mixing a stain solution, hydrogen peroxide, and a catalyst solution.

Figure 2 shows the Fenton reaction mechanism of iron and copper.

Figure 3 shows the result of confirming the difference in brightness (ΔE) of Hydroxyapatite specimens before and after application of the whitening patch when different types of catalysts were used.

Figure 4 shows a SEM picture of the copper-iron coprecipitate.

5 is a component analysis result of a copper-iron coprecipitate sample confirmed by EDS.

Hereinafter, examples and the like will be described in detail to aid understanding of the present invention. However, the embodiments according to the present invention can be modified in many different forms, and the scope of the present invention should not be construed as being limited to the following examples. Embodiments of the present invention are provided to more completely explain the present invention to those skilled in the art. % in this specification may be understood to mean weight % unless otherwise specified.

[Experimental Example 1] Organic matter decomposition effect experiment of hydrogen peroxide (solution experiment)

1. Experiment method

1) Stain solution

Coffee, black tea, and mucin powder mixed in a ratio of 8: 6: 6 are dissolved in purified water at a concentration of 1%, and the pH is adjusted to 4, 7, and 10 with phosphoric acid and trisodium phosphate. (Stain solution)

2) catalyst solution

Dissolve in purified water so that the sum of ferrous chloride or ferric chloride and copper sulfate is 1% of the total (catalyst solution)

	Fe(II) 1.0%	Fe(III) 1.0%	Cu(II) 1.0%	Fe 0.2% + Cu 0.8%	Fe 0.5% + Cu 0.5%	Fe 0.8% + Cu 0.2%
Purified water	99	99	99	99	99	99
ferrous chloride	One
ferric chloride		One		0.2	0.5	0.8
copper sulfate			One	0.8	0.5	0.2

3) Measurement of color change of solution Put 2 mL of stain solution, 1 mL of 10% hydrogen peroxide aqueous solution, and 0.2 mL of catalyst solution of 2) and take an initial picture in a studio box. Exactly 30 minutes later, another photo is taken under the same conditions, and the RGB values of the photo are converted into CIELab to calculate the amount of color change (ΔE).

2. Experimental results

The amount of color change (ΔE) was expressed as follows.

	pH 4	pH 7	pH 10
catalyst x	6.31	22.10	38.32
Fe(II) 1%	14.90	46.78	53.66
Fe(III) 1%	14.99	40.60	53.08
Cu(II) 1%	9.84	47.57	57.80
Fe(III) 0.2% + Cu(II) 0.8%	10.86	50.97	71.97
Fe(III) 0.5% + Cu(II) 0.5%	6.97	43.65	72.17
Fe(III) 0.8% + Cu(II) 0.2%	6.94	36.92	69.83

3. Interpretation of experimental results

The organic matter (coloring factor) decomposition effect of hydrogen peroxide increased as the pH increased, and showed the highest activity in basicity when iron and copper were mixed.

[Experimental Example 2]. Whitening effect evaluation (in vitro)

1. Experiment method

1) Preparation of colored hydroxyapatite (HAP) tablet specimens

The hydroxyapatite powder was pressed with an IR press of 4.2 tons to make a tablet with a diameter of 12.5 mm and a thickness of 1.8 mm, sintered at 1,000 ° C, molded with epoxy resin to make a resin, and after etching the surface with strong acid, The process of immersing and drying the specimen in a TSB (trypticase soybroth) solution in which coffee, iron, and mucin were dissolved was repeated, and this operation was continued for one week to contaminate the specimen. After contamination, the specimen was lightly washed with a toothbrush in running water to remove contamination that was dissolved or easily removed by water, and then dried at room temperature. In the experiment, those with an L value of 45 or less were used.

2) Whitening effect evaluation method

The initial brightness value of the colored hydroxyapatite tablet specimen was measured with a colorimeter (Spectro photometer NF555), 0.05 g of agent 1 was applied to the specimen soaked in water, and a White Now ™ whitening patch (3% hydrogen peroxide) was attached thereon. After a certain period of time (20 minutes), the patch was removed, lightly rubbed with a toothbrush under running water, dried at room temperature, and brightness was measured. ΔE, which is the difference in brightness before and after attaching the patch, was calculated. Repeat 3 times, total 60 minutes applied.

3) Catalyst Gel Manufacturing Method

	Comparative Example 1	Comparative Example 2	Comparative Example 3	Comparative Example 4	Example 1	Example 2
Purified water	59.8	59.8	59.8	56.3	59.3	58.3
glycerin	20	20	20	20	20	20
PVP	12	12	12	12	12	12
tribasic potassium phosphate	4	4	4	4.5	4.5	4.5
saccharin	0.5	0.5	0.5	0.5	0.5	0.5
taurine	0.2	0.2	0.2	0.2	0.2	0.2
sodium citrate				2
colloidal silicon dioxide	2.5	2.5	2.5	2.5	2.5	2.5
ferrous chloride	One
ferric chloride		One		One
copper sulfate			One	One
coprecipitate					One	2
ToTal	100	100	100	100	100	100
pH	10.05	9.93	10.06	9.57	9.81	9.74

① Dissolve salts except glycerin and pH adjusting agent (tribasic potassium phosphate) sufficiently in purified water, and then raise the pH to 8 or higher using the pH adjusting agent. If coprecipitation needs to be suppressed, if sodium citrate is added in the amount of iron salt + copper salt, coprecipitation does not occur. ※ As soon as the pH rises, coprecipitates are formed.

② If the pH adjusting agent is added when the salt (especially iron and copper salt) is not sufficiently dissolved, or if the iron/copper salt and the pH adjusting agent are added together, the coprecipitate is not formed evenly.

③ After co-precipitation is formed (after all pH adjusting agents are dissolved), a thickening agent (PVP) is added.

2. Experimental results

ΔE, the difference in brightness before and after attaching the patch, is as follows.

	20min	40min	60min
Apply whitening agent only	2.10	6.91	10.02
Comparative Example 1	3.08	9.30	15.92
Comparative Example 2	2.92	9.12	16.20
Comparative Example 3	3.04	7.73	14.94
Comparative Example 4	5.44	14.21	20.83
Example 1	7.02	16.95	24.92
Example 2	8.12	18.05	30.75

3. Interpretation of experimental results

When a catalyst containing both ferric chloride and copper sulfate was applied, the catalytic effect was significantly higher than when a catalyst containing only ferric chloride or copper sulfate was applied. In particular, it was found that the effect of the formulation in which co-precipitation occurred was better than that adjusted so that co-precipitation of iron and copper did not occur.

The present invention may be used as a tooth whitening agent.

Claims (15)

1. An oral composition for promoting, improving, or improving tooth whitening comprising a co-precipitate formed by at least two metal salts as an activator of peroxide,

   The oral composition of the oral composition having a pH range of 6 to 14.
2. The oral composition of claim 1, wherein the coprecipitate is a copper-iron coprecipitate.
3. The oral composition of claim 1, wherein the oral composition has a pH ranging from 9 to 11.
4. The method of claim 1, wherein the oral composition is alginate (Alginate), hydroxypropyl methylcellulose (HPMC), hydroxyethyl cellulose (HEC), methyl cellulose (Methyl cellulose), carboxymethyl cellulose (CMC), gelatin (Gelatin) , Collagen, Agar, Starch, Pectin, Polyvinyl alcohol, Hyaluronan, Carbomer, Acrylate copolymer ), Shellac, and polyvinylpyrrolidone (Polyvinylpyrolidone) Oral composition comprising at least one polymer as a thickener.
5. The oral composition of claim 1, wherein the oral composition is a gel formulation having a viscosity of 2,000 to 50,000 cps.
6. The oral composition of claim 1, wherein the oral composition is applied to the tooth surface before the tooth whitening composition containing peroxide is applied to the tooth surface, or applied thereon after application to the tooth surface.
7. A first agent comprising an oral composition for accelerating, improving, or enhancing tooth whitening having a pH in the range of 6 to 14, including a co-precipitate formed by at least two metal salts as an activator of peroxide; and

   A tooth whitening product comprising a second agent comprising a tooth whitening composition containing peroxide,

   A kit for teeth whitening wherein the peroxide included in the second agent is activated in an environment having a pH range of 6 to 14 created by application of the first agent to have a tooth whitening effect.
8. The kit for whitening teeth according to claim 7, wherein the peroxide is at least one selected from the group consisting of hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium peroxypyrophosphate, and sodium percarbonate.
9. 8. The kit for whitening teeth according to claim 7, wherein the second agent is a patch for attaching teeth to release peroxide to teeth.
10. A method for producing an oral composition for promoting, improving, or improving tooth whitening, comprising a coprecipitate of two or more metal ions as a tooth whitening active agent,

    S1) copper precursor; and preparing a metal precursor aqueous solution containing an iron precursor;

    S2) adding a pH adjusting agent to the aqueous solution so that the pH is in the range of 6 to 14; and

    S3) A method for preparing an oral composition for accelerating, improving, or improving tooth whitening comprising the step of mixing the introduced pH adjusting agent to form a solution containing a copper-iron coprecipitate.
11. The method of claim 10, further comprising the step of preparing a gel by adding a thickening agent to the solution of step S4).
12. 11. The method of claim 10, wherein the pH adjusting agent comprises at least one selected from the group consisting of sodium hydroxide, potassium hydroxide, sodium phosphate, disodium phosphate, trisodium phosphate, sodium pyrophosphate, and tripotassium phosphate.
13. 11. The method of claim 10, wherein the step S3)

    At least one chelating agent selected from the group consisting of tetrasodium pyrophosphate, sodium acid pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate, and acidic polyphosphate; or

    A method for producing polyhydric acids including citric acid, tartaric acid, oxalic acid, succinic acid, or mixtures thereof, or salts thereof.
14. 11. The method of claim 10, wherein the copper precursor and iron precursor are derived from copper sulfate and ferric chloride, respectively.
15. An oral composition for promoting, improving, or enhancing tooth whitening comprising the copper-iron coprecipitate prepared by the method of any one of claims 10 to 14.

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