KR20190061919A - Composition for Tooth whitening - Google Patents

Abstract

The present invention provides a tooth whitening composition comprising a non-aqueous solvent and a reducing agent, wherein the composition provides a tooth whitening composition substantially free from water. The tooth whitening composition of the present invention can enhance the stability of the reducing agent and improve the tooth whitening effect.

Description

[Composition for Tooth whitening]

The present invention relates to a composition for whitening teeth, and more particularly to a composition for whitening teeth without irritating tissues around teeth and teeth.

A bright, white smile helps a person to have a confident interpersonal relationship. Confident smiles also make first impressions more positive.

Tooth whitening is a dental treatment that brightens the tooth color without damaging the teeth that have been discolored for various reasons. Recently, teeth whitening products that can be used in the home have been developed.

The types and methods of tooth whitening vary, but the most common method is to bleach by oxidizing the coloring factors of teeth using a high concentration of hydrogen peroxide. However, the oxidation reaction using hydrogen peroxide is a very irritating reaction and has strong irritation when it comes into contact with the lips, gums, and tongue.

The tooth surface consists of dentin surrounding the nerve and enamel surrounding the dentin. Previously, applying a tooth whitening agent with a hydrogen peroxide concentration of 35%, the laser penetrated into the dentin surrounding the nerve of the tooth and caused this scalding symptom. In addition, incorrect dosing of tooth whitening agents with high levels of hydrogen peroxide may cause severe irritation to mouth, throat and esophagus. The risk of using hydrogen peroxide was so high that the specialist whitening hydrogen peroxide concentration, which the Food and Drug Administration could treat, took measures to reduce it to 15%.

Therefore, there is always a demand for tooth whitening that does not use hydrogen peroxide. However, among products present in the market, whitening products that do not use hydrogen peroxide are ineffective, and in the case of techniques that can experience effects, stabilization of ingredients is required .

The object of the present invention is to provide a composition for whitening teeth with less irritation, and a tooth whitening method in place of an oxidizing agent capable of causing irritation to teeth and / or gums.

The present invention provides a composition capable of whitening a tooth by modifying the structure of a coloring factor of a tooth through a reduction reaction rather than an oxidation reaction, and a tooth whitening method using the composition.

The present invention is also intended to increase the stability of the reducing agent after the tooth whitening component is dispersed in the non-aqueous system (especially the oil).

In order to solve the above problems, the present invention provides a composition for teeth whitening which comprises a non-aqueous solvent and a reducing agent and is substantially free of water.

The inventors of the present invention have found that it is difficult to stabilize a whitening component in a tooth whitening composition containing a reducing agent, and have completed the present invention in order to solve this problem.

An oxidative whitening agent such as hydrogen peroxide is frequently used for the removal of endogenous and / or extraneous coloring factors stained in teeth. However, the present inventors intend to provide a method which does not use an oxidative whitening agent.

The inventors of the present invention have made efforts to improve tooth whitening efficiency without using an oxidative whitening agent that causes irritation in the oral cavity, and have completed the present invention. The inventors of the present invention have found that when a non-aqueous solvent is used as a solvent for delivering a reducing whitening agent to a tooth, the tooth whitening effect is improved.

The non-aqueous solvent may be at least one selected from the group consisting of propylene glycol, glycerin, polyethylene glycol, mineral oil, and vegetable oil, and preferably vegetable oil may be used.

Examples of the mineral oil include paraffin oil and the like.

The vegetable oil may be any one or more selected from the group consisting of olive oil, soybean oil, canola oil, grape seed oil, castor oil, cottonseed oil, corn oil, sesame oil and peanut oil, preferably olive oil, soybean oil, castor oil, And more preferably, soybean oil can be used. Soybean oil can enhance the stability of the reducing agent and further improve the tooth whitening effect.

The composition of the present invention may be substantially free of water. Substantially free of water in this context means that the water comprises not more than 5% by weight, not more than 1% by weight, not more than 0.5% by weight, not more than 0.1% by weight, not more than 0.05% by weight, not more than 0.01% by weight based on the total weight of the composition And it is to be understood that the present invention is not limited thereto.

The reducing agent of the present invention can be used without limitation as long as it is a reducing agent that can be used as a food additive and is preferably selected from potassium metabisulfite, , Sodium hydrosulfite, and sodium metabisulfite may be used as a reducing agent. Preferably, sodium metabisulfite, sodium hypasulfate, or mixtures thereof may be used for the purposes of the present invention.

The composition of the present invention may further comprise a thickening agent.

The thickener may include at least one silica compound selected from the group consisting of synthetic silica such as sodium salt of silicate such as sodium silicate and calcium silicate, synthetic silica such as silica gel, and pyrogenic silica such as fumed silica; And one or more cellulose selected from the group consisting of hydroxyethyl cellulose, carboxymethyl cellulose, and methyl cellulose, and may be any one or more selected from the group consisting of Evonik's Fumed silica (Aerosil ^® 200) can be used.

In one embodiment of the present invention, the composition may comprise from 1 to 20% by weight of an increasing agent based on the total weight of the non-aqueous solvent. Preferably 5 to 15% by weight, more preferably 8 to 18% by weight. The reducing agent can be most stabilized in the above content range, and the tooth whitening effect can be excellent.

The composition of the present invention may further comprise a coloring factor remover capable of removing the coloring factor which is removed from the tooth surface or is weakened in adhesion by the reducing agent. The coloring factor remover may further be included to improve the tooth whitening effect. Preferably, the coloring agent scavenger is pyrophosphate; Multi-phosphate _{(multiphosphate) (NaPO 3) n} , or _{(KPO 3) n (n =} 3 ~ 24); EDTA; (Sodium succinate, sodium tartrate, sodium malate, sodium citrate, potassium succinate, potassium tartrate, potassium malate, potassium citrate or the like) or a salt thereof (such as sodium citrate, succinic acid, tartaric acid, malic acid, ), And the like. More preferably, the coloring factor removing agent may be pyrophosphate.

The pyrophosphate may preferably comprise tetrasodium pyrophosphate (TSPP), sodium acid pyrophosphate (SAPP) or a mixture thereof.

In one embodiment, when sodium hydrosulfite is used as the reducing agent, TSPP (tetrasodium pyrophosphate) can be used. The stability of sodium hydrosulfite is particularly excellent when the TSPP is included, and the tooth whitening effect can be improved by inducing a basic environment in an aqueous solution.

The composition can be used without particular limitation as long as it is a formulation that can be used for oral tooth whitening. Examples of the composition include a toothpaste, a mouth spray, a mouthwash, an oral ointment, a mouthwash, a gumming product, a gum, . ≪ / RTI > When the composition of the present invention is provided in the form of a patch for tooth whitening, the patch may be dissolved in the oral cavity or may be provided in a form removable after attachment in the oral cavity. In particular, the form of the patch may be used without limitation. The oral product of the present invention may be in the form of a liquid, a solid, a suspension, a gel, or an aerosol, but is not limited thereto. In the tooth whitening composition of the present invention, suitable additives, carriers, and the like may be further included in order to apply to the oral product of the present invention. Such additives and carriers may be suitably selected and combined by those skilled in the art .

The formulations prepared using the tooth whitening composition of the present invention can be prepared by a method commonly used in the art.

The composition of the present invention can improve the tooth whitening effect.

The composition of the present invention can improve the stability of a reducing agent having a tooth whitening effect.

INDUSTRIAL APPLICABILITY The present invention can provide a new tooth whitening agent which alleviates the irritation in the oral cavity of the oxidative tooth whitening agent.

Hereinafter, embodiments of the present invention will be described in detail to facilitate understanding of the present invention. However, the embodiments according to the present invention can be modified into various other forms, and the scope of the present invention should not be construed as being limited to the following embodiments. Embodiments of the invention are provided to more fully describe the present invention to those skilled in the art.

[Preparation of composition for tooth whitening]

Each component of the following Table 1 was mixed to prepare a composition for teeth whitening of Examples and Comparative Examples. Particularly, before the reducing agent was settled, the dispersing agent was added by adding a thickening agent.

Comparative Example 1 Example 1 Example 2 Example 3 Mechanism Water 88.0 - - - Olive oil - 88.0 - - Soy bean oil - - 88.0 - Castor oil - - - 88.0 Incrementer Fumed silica
(Aerosil 200 ^* ) 8.0 8.0 8.0 8.0 reducing agent Sodium
metabisulfite 3.0 3.0 3.0 3.0 A coloring agent remover Sodium acid
피rophosphate 1.0 1.0 1.0 1.0 Comparative Example 2 Example 4 Example 5 Example 6 Mechanism Water 88.0 - - - Olive oil - 88.0 - - Soy bean oil - - 88.0 - Castor oil - - - 88.0 Incrementer Fumed silica
(Aerosil 200) 8.0 8.0 8.0 8.0 reducing agent Sodium
hydrosulfite 3.0 3.0 3.0 3.0 A coloring agent remover Tetrasodium
피rophosphate 1.0 1.0 1.0 1.0

* Evonik's Fumed silica (Aerosil 200)

<Reductant Quantitative Test>

The reducing agent in Table 1 was quantified in the following manner.

1. Sodium metabisulfite determination method

Was dissolved in an Erlenmeyer flask equipped with a solvent (methylene chloride 10, ethanol 40, distilled water 2.5, 1N hydrochloric acid 2.5), and dissolved in 5 ml of a 0.1N iodine solution in an open flask equipped with a stopper. The solution was allowed to stand for 5 minutes, Of iodine was titrated with 0.1 N sodium thiosulfate solution. (Indicator: starch solution)

2. Sodium hydrosulfite determination method

10 ml of water is added to 10 ml of formalin, neutralized with sodium hydroxide solution, and about 1.0 g of this product is precisely weighed. Hydrochloric acid (1 → 10) was added to adjust the pH to 1.1-1.5 and titrated with 0.1N iodine solution (indicator: starch solution).

<Comparison of whitening effect>

1. Preparation of colored hydroxyapatite (HAP) tablet specimens

Hydroxyapatite powders were pressed with an IR press at a pressure of 4.2 ton to prepare tablets having a diameter of 12.5 mm and a thickness of 1.8 mm. The tablets were sintered at 1,000 ° C and molded with an epoxy resin to synthesize a resin. Thereafter, the surface was etched with a strong acid, and the specimen prepared for one week for 8 hours was then contaminated with a TSB (trypticase soybroth) solution in which tea, coffee, iron, and mucin were dissolved and an automatic coloring machine rotating at 0.5 RPM . Then, the specimen was rinsed lightly with running water with a toothbrush to remove the contamination which was dissolved by water or easily removed, and then dried at room temperature.

2. Evaluation of whitening effect

The initial brightness values of the colored hydroxyapatite tablet specimens were measured with a colorimeter (Minolta, CR-321). The specimens were thoroughly wetted with distilled water. Each formulation was coated with 0.06 g of each formulation and kept for 1 hour. The running water was rubbed lightly with a toothbrush, and after drying at room temperature, the lightness was measured. The difference in lightness ΔE before and after application of the preparation was calculated.

Evaluation immediately after manufacture (? E) Evaluation after 2 weeks storage at 50 ℃ (ΔE) Comparative Example 1 18.7 ± 0.4 11.2 ± 0.4 Comparative Example 2 25.9 ± 0.3 11.9 ± 0.1 Example 1 19.0 ± 0.3 17.9 + 0.4 Example 2 18.6 ± 0.3 18.0 ± 0.2 Example 3 19.3 ± 0.4 18.1 ± 0.4 Example 4 23.4 ± 0.2 21.0 ± 0.2 Example 5 24.2 ± 0.3 23.2 ± 0.3 Example 6 25.0 + - 0.4 23.1 ± 0.2

In order to evaluate the stability of the reducing agent, the whitening effect was evaluated before and after the harsh condition treatment, and the whitening effect was similar immediately after the preparation, but there was a clear difference between the agent in which the solvent was water after the harsh conditioning treatment and the oil- appear.

3. Evaluation of stability of reducing agent over time

The stability of the teeth whitening composition of the present invention and compositions using water as a solvent (Comparative Examples 1 and 2) were evaluated.

The residual percentage of tooth whitening component over time was evaluated at 50 ℃ under severe condition.

Initial value 1 parking 2 parking Remaining rate (%) Comparative Example 1 2.86 2.57 1.86 65.03 Comparative Example 2 2.55 1.79 1.28 50.20 Experimental Example 1 2.88 2.76 2.71 94.10 Experimental Example 2 2.85 2.79 2.76 96.84 Experimental Example 3 2.86 2.71 2.69 94.06 Experimental Example 4 2.54 2.46 2.41 94.88 Experimental Example 5 2.56 2.53 2.46 96.09 Experimental Example 6 2.54 2.41 2.36 92.91

As a result of the stability test conducted under severe conditions at 50 ℃, the stability of the solvent using the edible oil was superior to that of the preparation using water.

<Result>

It was confirmed that the composition for teeth whitening of the present invention is more excellent in the stability of the reducing agent, which is a whitening component, as compared with the case of using water as a solvent. As the time passes, the whitening component may be degraded and the tooth whitening efficiency may be lowered. However, when the edible oil is used as a solvent, the whitening component remained superior to the initial value and the whitening effect was excellent.

[Production of toothpaste for tooth whitening]

Tooth whitening dentifrices containing the compositions of Examples 1 to 6 were prepared.

[Preparation of tooth whitening oral cleanser]

A tooth whitening mouthwash containing the compositions of Examples 1 to 6 was prepared.

Claims (13)

A composition for teeth whitening comprising a non-aqueous solvent and a reducing agent,
Wherein the composition is substantially free of water. The tooth whitening composition according to claim 1, which is at least one selected from the group consisting of non-aqueous propylene glycol, glycerin, polyethylene glycol, mineral oil, and vegetable oil. The tooth whitening composition according to claim 2, wherein the vegetable oil is at least one selected from the group consisting of olive oil, soybean oil, canola oil, grape seed oil, castor oil, cottonseed oil, corn oil, sesame oil and peanut oil. The method of claim 1, wherein the reducing agent is selected from the group consisting of Potassium Metabisulfite, Sulfur Dioxide, Sodium Sulfite, Sodium Bisulfite, Sodium Hydrosulfite, And sodium metabisulfite. The tooth whitening composition according to claim 1, The tooth whitening composition of claim 1, wherein the composition further comprises a thickening agent. 6. The method of claim 5, wherein the thickener is selected from the group consisting of sodium silicates, calcium silicate, silica gel, and fumed silica; And at least one selected from the group consisting of hydroxyethylcellulose, carboxymethylcellulose, and methylcellulose. The tooth whitening composition of claim 6, wherein the composition comprises from 1 to 20% by weight of a thickening agent based on the total weight of the non-aqueous solvent. The tooth whitening composition according to claim 1, wherein the composition has any one or more formulations selected from the group consisting of toothpaste, oral spray, mouthwash, oral ointment, mouthwash, gummed product, gum, and patch . The tooth whitening composition according to claim 8, wherein the patch is dissolved in the oral cavity or attached to the oral cavity and detached. The tooth whitening composition of claim 1, wherein substantially no water comprises no water in the composition or comprises no more than 5% by weight of water based on the total weight of the composition. The tooth whitening composition of claim 5, wherein the composition further comprises a coloring factor remover. 12. The method of claim 11, wherein the coloring agent removing agent is pyrophosphoric acid; (NaPO _{3) n,} or _{(KPO 3) n (n =} 3 ~ 24) are multi-phosphate; EDTA; And a multi-carboxylate. &Lt; Desc / Clms Page number 24 &gt; 13. The method of claim 12, wherein the multicarboxylate is selected from the group consisting of succinic acid, tartaric acid, malic acid, or citric acid; Or a salt thereof,
Wherein the salt thereof is sodium succinate, sodium tartrate, sodium malate, sodium citrate, potassium succinate, potassium tartrate, potassium malate, potassium citrate or a mixture thereof.