WO2023096535A1 - Smoking cessation agent - Google Patents
Smoking cessation agent Download PDFInfo
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- WO2023096535A1 WO2023096535A1 PCT/RU2022/050315 RU2022050315W WO2023096535A1 WO 2023096535 A1 WO2023096535 A1 WO 2023096535A1 RU 2022050315 W RU2022050315 W RU 2022050315W WO 2023096535 A1 WO2023096535 A1 WO 2023096535A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nicotine
- smoking
- means according
- toothpaste
- surfactant
- Prior art date
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- 230000005586 smoking cessation Effects 0.000 title abstract description 4
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims abstract description 38
- 229960002715 nicotine Drugs 0.000 claims abstract description 36
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims abstract description 36
- 230000000391 smoking effect Effects 0.000 claims abstract description 25
- 229940034610 toothpaste Drugs 0.000 claims abstract description 9
- 239000000606 toothpaste Substances 0.000 claims abstract description 9
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims abstract description 6
- 239000003765 sweetening agent Substances 0.000 claims abstract description 6
- 239000003906 humectant Substances 0.000 claims abstract description 5
- 239000003755 preservative agent Substances 0.000 claims abstract description 5
- 239000004094 surface-active agent Substances 0.000 claims abstract description 5
- 239000000454 talc Substances 0.000 claims abstract description 4
- 229910052623 talc Inorganic materials 0.000 claims abstract description 4
- 239000003082 abrasive agent Substances 0.000 claims abstract description 3
- 239000000796 flavoring agent Substances 0.000 claims abstract 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 4
- 239000003205 fragrance Substances 0.000 claims description 4
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims description 3
- 229920001817 Agar Polymers 0.000 claims description 3
- 241000723346 Cinnamomum camphora Species 0.000 claims description 3
- 241000206672 Gelidium Species 0.000 claims description 3
- 235000011751 Pogostemon cablin Nutrition 0.000 claims description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 3
- 235000010419 agar Nutrition 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- 229960000846 camphor Drugs 0.000 claims description 3
- 229930008380 camphor Natural products 0.000 claims description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 3
- 239000000341 volatile oil Substances 0.000 claims description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 2
- 235000006679 Mentha X verticillata Nutrition 0.000 claims description 2
- 235000002899 Mentha suaveolens Nutrition 0.000 claims description 2
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims description 2
- 235000011187 glycerol Nutrition 0.000 claims description 2
- 229940041616 menthol Drugs 0.000 claims description 2
- 239000002304 perfume Substances 0.000 claims description 2
- 230000002335 preservative effect Effects 0.000 claims description 2
- 241000222666 Boerhavia diffusa Species 0.000 claims 1
- 235000019634 flavors Nutrition 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 abstract description 5
- 206010012335 Dependence Diseases 0.000 abstract description 2
- 229940112822 chewing gum Drugs 0.000 description 7
- 235000015218 chewing gum Nutrition 0.000 description 7
- 235000019504 cigarettes Nutrition 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000000034 method Methods 0.000 description 4
- 241000208125 Nicotiana Species 0.000 description 3
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 3
- 208000025569 Tobacco Use disease Diseases 0.000 description 3
- 230000001055 chewing effect Effects 0.000 description 3
- 239000004604 Blowing Agent Substances 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 240000002505 Pogostemon cablin Species 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 230000001680 brushing effect Effects 0.000 description 2
- 238000002485 combustion reaction Methods 0.000 description 2
- 239000007933 dermal patch Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- LELOWRISYMNNSU-UHFFFAOYSA-N hydrogen cyanide Chemical compound N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 description 2
- 229940100662 nasal drops Drugs 0.000 description 2
- 229940087730 nicorette Drugs 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 241000645874 Cymbopogon refractus Species 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 206010052437 Nasal discomfort Diseases 0.000 description 1
- 206010057852 Nicotine dependence Diseases 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 235000019788 craving Nutrition 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 235000011475 lollipops Nutrition 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 239000007923 nasal drop Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 238000011458 pharmacological treatment Methods 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Definitions
- the claimed invention relates to means for quitting smoking, and can be used as a means of gradual weaning from a bad habit.
- Nasal drops containing nicotine have been reported (Russell et al., British Medical Journal, Vol. 286, p. 683 (1983); Jarvis et al., Brit. J. on Addiction, Vol. 82, p. 983 (1987)) . Nose drops, however, are difficult to application and inconvenient for use at work or in other social situations.
- the introduction of nicotine by delivery directly into the nasal cavity by spraying is known from US Patent No. 4 579 858, DE 32 41 437 and WO93/12764.
- local nasal irritation may occur with the use of nasal nicotine formulations.
- the complexity of administration also leads to unpredictability of the dose of nicotine administered.
- Nicorette® chewing gum One of the successful products that are used as a smoking substitute and/or as a smoking cessation agent and which are based on nicotine is Nicorette® chewing gum.
- This product was one of the first forms of nicotine replacement approved by the Food and Drug Administration (FDA) and is still one of the most commonly used nicotine replacement products today.
- Nicorette® chewing gum has been on the market for several years in about 60 countries. In this chewing gum, nicotine is present as a complex with an insoluble cation exchanger (polacrylex) which is dispersed in the gum base. Nicotine is slowly released from chewing gum by chewing and reaches the same plasma level as when smoking a cigarette after about 30 minutes, depending on the method of chewing, i.e. slowly or actively.
- Patents related to this product are, for example, US Patent No. 3877,468, US Patent No. 3,901,248 and US Patent No. 3,845,217.
- the present invention mainly aims to provide a tool for quitting smoking, providing an increase in the effectiveness of quitting smoking, which is the achieved technical result.
- the tool for quitting smoking is made in the form of a toothpaste of the following composition, wt. %: abrasives 70-78%, including talc humectants 10-15% fragrances and/or perfume and/or sweeteners 5-10% preservatives and fresheners 5-10%
- this tool for quitting smoking compares favorably with chewing gum containing nicotine, in that when chewing, an unconditioned reflex occurs with the release of gastric juice, but the appetite does not increase, because. nicotine enters the body, this combination inevitably leads to gastritis and stomach ulcers.
- glycerin is used as a humectant. Due to this advantageous characteristic, it becomes possible to use an inexpensive product as a humectant, which is miscible with water in any proportions, and is partly a sweetener.
- camphor is used as a preservative. Thanks to this advantageous characteristic, it becomes possible to use the fact that camphor has anti-inflammatory and antiseptic effects.
- blowing agent In general, cheaper laurils, as well as natural soap grass and other blowing agents, can be used as a blowing agent.
- patchouli essential oil is used as a fragrance. Thanks to this advantageous characteristics, it becomes possible for toothpaste due to patchouli essential oil to have a more pronounced antibacterial effect.
- mint is used as a fragrance. Thanks to this advantageous characteristic, it becomes possible to give the toothpaste a refreshing effect on the mouth.
- agar-agar is used as a sweetener. Thanks to this advantageous characteristic, it becomes possible to increase the therapeutic effect of the use of the proposed toothpaste, since the algae that produce agar-agar are unusually rich in iodine, calcium, iron and other valuable substances and trace elements.
- nicotine When using the claimed means for quitting smoking, nicotine is absorbed through the oral mucosa during brushing your teeth (as when smoking), but without polluting the lungs with combustion products, and also, without getting into digestion with saliva, as when smoking (chewing gum and tablets), it is rinsed with paste. Pure nicotine, received by the body through the mucosa, reduces the need for smoking, thereby facilitating the condition of the smoker during periods of withdrawal and helps restore vital activity, gradually reducing smoking.
- the proposed tool for quitting smoking in the form of a toothpaste containing nicotine has successfully passed certification in the Russian certification center for compliance with the requirements of the standards. In addition, many consumers have already appreciated the effect of using this tool.
- the data are based on the opinions of smokers, recommendations of doctors and instructions for the use of drugs.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medical Informatics (AREA)
- Addiction (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
Abstract
The claimed invention relates to smoking cessation agents, and can be used as an agent for gradually overcoming addiction. According to the invention, the agent is in the form of a toothpaste having the following composition: 70-78 wt% abrasive agents, including talc, 10-15% wt% humectants, 5-10% wt% flavourings and/or essence and/or sweeteners, 5-10 wt% preservatives and freshening agents, 1-5 wt% surfactant, 1-5 wt% nicotine. The technical result achieved is more effective cessation of smoking.
Description
СРЕДСТВО ДЛЯ БРОСАЮЩИХ КУРИТЬ QUIT SMOKER
Область техники, к которой относится изобретение. The field of technology to which the invention belongs.
Заявляемое изобретение относится к средствам для бросающих курить, и может быть использовано в качестве средства постепенного отвыкания от вредной привычки. The claimed invention relates to means for quitting smoking, and can be used as a means of gradual weaning from a bad habit.
Уровень техники. The level of technology.
Большинству курильщиков чрезвычайно трудно бросить курить, поскольку курение табака приводит к физической зависимости, это происходит в следствии того что организм перестает вырабатывать собственный никотин, т.к. он поступает в избытке из вне во время курения. Для курильщиков характерна сильная склонность к рецидивам после того, как они на какое-то время успешно бросили курить. Многие отмечают увеличение аппетита и сильно набирают вес, что также является причиной продолжать курить. Самым опасным для курильщика являются вещества, образующиеся в процессе горения табака: канцерогенные продукты дегтя, окись углерода, N-нитрозамины, альдегиды и синильная кислота. Именно эти вещества (а не никотин, вызывающий зависимость) отравляют организм курильщика, через дыхательную и далее кровеносную систему, поэтому цвет кожи курильщика отличается от цвета кожи здорового человека серым оттенком. It is extremely difficult for most smokers to quit smoking because smoking tobacco leads to physical dependence, this is due to the fact that the body stops producing its own nicotine. it comes in excess from outside while smoking. Smokers are characterized by a strong tendency to relapse after they have successfully quit smoking for some time. Many people notice an increase in appetite and gain a lot of weight, which is also a reason to continue smoking. The most dangerous for a smoker are substances formed during the combustion of tobacco: carcinogenic tar products, carbon monoxide, N-nitrosamines, aldehydes and hydrocyanic acid. It is these substances (and not addictive nicotine) that poison the smoker's body through the respiratory and further circulatory system, so the smoker's skin color differs from the skin color of a healthy person in a gray tint.
В настоящее время препараты, содержащие никотин, являются доминирующим средством лечения табачной зависимости. В качестве помощи тем, кто хочет бросить курить, на рынке существует несколько способов и форм продуктов для замены никотина. Было описано несколько методов и средств для уменьшения желания субъекта употреблять табак, которые включают этап введения субъекту никотина или его производного, как описано, например, в Патенте США № 5,810,018 (пероральный никотинсодержащий спрей), Патенте США № 5,939,100 (никотинсодержащие микросферы) и Патенте США № 4,967,773 (никотинсодержащий леденец). Currently, nicotine preparations are the dominant treatment for tobacco dependence. As an aid to those who want to quit smoking, there are several ways and forms of nicotine replacement products on the market. Several methods and means have been described for reducing a subject's desire to use tobacco, which include the step of administering nicotine or a derivative thereof to the subject, as described, for example, in US Patent No. 5,810,018 (oral nicotine-containing spray), US Patent No. 5,939,100 (nicotine-containing microspheres) and US Patent No. 4,967,773 (nicotine lozenge).
Сообщалось о носовых каплях, содержащих никотин (Рассел и др., Британский медицинский журнал, Том 286, стр. 683 (1983); Джарвис и др., Брит. Дж. о зависимости, Т. 82, с. 983 (1987)). Капли в нос, однако, сложны в
применении и неудобны для использования на работе или в других общественных ситуациях. Введение никотина путем доставки непосредственно в носовую полость путем распыления известно из Патента США № 4 579 858, DE 32 41 437 и WO93/12764. Однако при использовании назальных никотиновых составов может наблюдаться местное раздражение носа. Сложность введения также приводит к непредсказуемости вводимой дозы никотина. Nasal drops containing nicotine have been reported (Russell et al., British Medical Journal, Vol. 286, p. 683 (1983); Jarvis et al., Brit. J. on Addiction, Vol. 82, p. 983 (1987)) . Nose drops, however, are difficult to application and inconvenient for use at work or in other social situations. The introduction of nicotine by delivery directly into the nasal cavity by spraying is known from US Patent No. 4 579 858, DE 32 41 437 and WO93/12764. However, local nasal irritation may occur with the use of nasal nicotine formulations. The complexity of administration also leads to unpredictability of the dose of nicotine administered.
Сообщалось об использовании кожных пластырей для трансдермального введения никотина (Rose, in Pharmacological Treatment of Tobacco Dependence, (1986), стр. 158-166, Harvard Univ. Пресса). Никотинсодержащие пластыри на коже, которые широко используются сегодня, могут вызывать местное раздражение, а всасывание никотина происходит медленно и зависит от кожного кровотока. The use of skin patches for transdermal administration of nicotine has been reported (Rose, in Pharmacological Treatment of Tobacco Dependence, (1986), pp. 158-166, Harvard Univ. Press). The nicotine-containing skin patches that are widely used today can cause local irritation, and nicotine absorption is slow and dependent on cutaneous blood flow.
Кроме того, устройства для вдыхания, напоминающие сигарету, известны поглощением паров никотина, как это предлагается в патенте США № 5,167,242. Указанные средства и методы плохо решают проблемы, связанные с зависимостью от никотина. In addition, cigarette-like inhalation devices are known for absorbing nicotine vapor, as taught in US Pat. No. 5,167,242. These means and methods do not solve the problems associated with nicotine addiction.
Одним из успешных продуктов, которые используются в качестве заменителя курения и/или в качестве средства для прекращения курения и которые основаны на никотине, является жевательная резинка Nicorette®. Этот продукт был одной из первых форм замены никотина, одобренной Управлением по контролю за продуктами питания и лекарствами (FDA), и до сих пор остается одним из наиболее часто используемых продуктов для замены никотина. Жевательная резинка Nicorette® уже несколько лет представлена на рынке примерно в 60 странах. В этой жевательной резинке никотин присутствует в виде комплекса с нерастворимым катионообменником (полакрилексом), который диспергирован в основе жевательной резинки. Никотин медленно выделяется из жевательной резинки в результате жевания и достигает такого же уровня в плазме, как при курении сигареты примерно через 30 минут, в зависимости от способа жевания, т. е. медленно или активно. Патенты, относящиеся к этому продукту, являются, например, патентами США № 3877,468, патентами США № 3,901 ,248 и патентами США № 3,845,217. One of the successful products that are used as a smoking substitute and/or as a smoking cessation agent and which are based on nicotine is Nicorette® chewing gum. This product was one of the first forms of nicotine replacement approved by the Food and Drug Administration (FDA) and is still one of the most commonly used nicotine replacement products today. Nicorette® chewing gum has been on the market for several years in about 60 countries. In this chewing gum, nicotine is present as a complex with an insoluble cation exchanger (polacrylex) which is dispersed in the gum base. Nicotine is slowly released from chewing gum by chewing and reaches the same plasma level as when smoking a cigarette after about 30 minutes, depending on the method of chewing, i.e. slowly or actively. Patents related to this product are, for example, US Patent No. 3877,468, US Patent No. 3,901,248 and US Patent No. 3,845,217.
Раскрытие изобретения.
Опирающееся на это оригинальное наблюдение настоящее изобретение, главным образом, имеет целью предложить средство для бросающих курить, обеспечивающее повышение эффективности бросания курить, что и является достигаемым техническим результатом. Disclosure of the invention. Based on this original observation, the present invention mainly aims to provide a tool for quitting smoking, providing an increase in the effectiveness of quitting smoking, which is the achieved technical result.
Для достижения этой цели средство для бросающих курить выполнено в виде зубной пасты следующего состава, масс. %: абразивные вещества 70-78%, включающие в себя тальк влагоудерживающие вещества 10-15% ароматизаторы и/или отдушка и/или подсластители 5-10% консерванты и освежители 5-10% To achieve this goal, the tool for quitting smoking is made in the form of a toothpaste of the following composition, wt. %: abrasives 70-78%, including talc humectants 10-15% fragrances and/or perfume and/or sweeteners 5-10% preservatives and fresheners 5-10%
■ ПАВ 1 -5% никотин 1-5%. ■ Surfactant 1-5% nicotine 1-5%.
Благодаря данным выгодным характеристикам появляется возможность того, что потребитель, не добавляя в свой образ жизни дополнительных действий (спрей, пластырь, леденец, жвачка), получает никотин в период отказа от курения в необходимой дозе, чтобы не испытывать тягу к курению утром и вечером. В научных изданиях, отмечается особая вредность утренних и вечерних перекуровThanks to these beneficial characteristics, it becomes possible that the consumer, without adding additional actions (spray, patch, lollipop, chewing gum) to his lifestyle, receives nicotine during the period of quitting smoking in the required dose so as not to feel cravings for smoking in the morning and evening. In scientific publications, there is a special harmfulness of morning and evening smoke breaks.
(https://www.gazeta.ru/science/2011/08/08_a_3726957.shtml). Кроме того, данное средство для бросающих курить выгодно отличается от жевательной резинки с содержанием никотина, тем что при жевании происходит безусловный рефлекс с выделением желудочного сока, но аппетит не повышается, т.к. в организм поступает никотин, данное сочетание неизбежно приводит к гастриту и язве желудка. Кроме того, потребители отмечают, что механика действий при чистке зубов и при курении схожа психологически, что дает эффект психологической замены и помогает при отказе от курения. (https://www.gazeta.ru/science/2011/08/08_a_3726957.shtml). In addition, this tool for quitting smoking compares favorably with chewing gum containing nicotine, in that when chewing, an unconditioned reflex occurs with the release of gastric juice, but the appetite does not increase, because. nicotine enters the body, this combination inevitably leads to gastritis and stomach ulcers. In addition, consumers note that the mechanics of brushing teeth and smoking are similar psychologically, which gives the effect of psychological replacement and helps with smoking cessation.
Диапазоны никотина были выбраны из следующих соображений: The nicotine ranges were chosen for the following reasons:
• Для курильщиков от 1 до 5 сигарет в день - 1 %. никотина. • For smokers from 1 to 5 cigarettes per day - 1%. nicotine.
• Для курильщиков от 6 до 10 сигарет в день - 2% никотина. • For smokers 6 to 10 cigarettes per day - 2% nicotine.
• Для курильщиков от 11 до 15 сигарет в день - 3% никотина.• For smokers 11 to 15 cigarettes per day - 3% nicotine.
• Для курильщиков от 16 до 20 сигарет в день - 4% никотина.• For smokers 16 to 20 cigarettes per day - 4% nicotine.
• Для курильщиков более 20 сигарет в день - 5% никотина.
Существует вариант изобретения, в котором для использования предлагаемого средства для бросающих курить более чем два раза в день, предлагается вариант состава зубной пасты, где в качестве абразива используется Тальк - это самый мягкий минерал, обеспечивающий наиболее бережное воздействие на эмаль, данный состав известен из патента РФ №2600443. • For smokers over 20 cigarettes per day - 5% nicotine. There is a variant of the invention, in which, in order to use the proposed tool for quitting smoking more than twice a day, a variant of the toothpaste composition is proposed, where Talc is used as an abrasive - this is the softest mineral that provides the most gentle effect on enamel, this composition is known from the patent RF No. 2600443.
Существует вариант изобретения, в котором в качестве влагоудерживающего вещества применяется глицерин. Благодаря данной выгодной характеристике появляется возможность использовать в качестве влагоудерживающего вещества недорогой продукт, который смешивается с водой в любых пропорциях, и частично является подсластителем. There is a variant of the invention in which glycerin is used as a humectant. Due to this advantageous characteristic, it becomes possible to use an inexpensive product as a humectant, which is miscible with water in any proportions, and is partly a sweetener.
Существует еще один вариант изобретения, в котором в качестве консерванта применяется камфора. Благодаря данной выгодной характеристике появляется возможность использовать то, что камфора обладает противовоспалительным и антисептическим действием. There is another variant of the invention in which camphor is used as a preservative. Thanks to this advantageous characteristic, it becomes possible to use the fact that camphor has anti-inflammatory and antiseptic effects.
Существует еще один вариант изобретения, в котором в качестве абразивного вещества применяется карбонат кальция. Благодаря данной выгодной характеристике появляется возможность использовать то свойство, что карбонат кальция - это мягкое полирующее вещество, участвует в процессе насыщения зубной ткани микроэлементами, предотвращает развитие кариеса. There is another variant of the invention in which calcium carbonate is used as an abrasive. Thanks to this advantageous characteristic, it becomes possible to use the property that calcium carbonate is a soft polishing substance, participates in the process of saturation of dental tissue with microelements, and prevents the development of caries.
Существует и такой вариант изобретения, в котором в качестве ПАВ применяется лаурилсульфат натрия. Благодаря данной выгодной характеристике появляется возможность обеспечение вспенивания, существует несколько видов лаурилсульфата натрия. Преимущественно предполагается использование чистого (пищевого) варианта - Tainoline AOS 97Р. There is also such a variant of the invention, in which sodium lauryl sulfate is used as a surfactant. Due to this advantageous characteristic, it becomes possible to provide foaming, there are several types of sodium lauryl sulfate. It is preferable to use a pure (food) version - Tainoline AOS 97P.
В общем в качестве вспенивающего вещества можно использовать и более дешевые лаурилы, а также натуральную траву мыльнянку и прочие вспениватели. In general, cheaper laurils, as well as natural soap grass and other blowing agents, can be used as a blowing agent.
Существует еще один вариант изобретения, в котором в качестве ароматизатора применяется эфирное масло пачули. Благодаря данной
выгодной характеристике появляется возможность зубной пасте за счет эфирного масла пачули иметь более выраженный антибактериальный эффект. There is another variant of the invention, in which patchouli essential oil is used as a fragrance. Thanks to this advantageous characteristics, it becomes possible for toothpaste due to patchouli essential oil to have a more pronounced antibacterial effect.
Существует кроме того один вариант изобретения, в котором в качестве отдушки применяется мята. Благодаря данной выгодной характеристике появляется возможность придать зубной пасте, освежающий полость рта эффект. There is also one variant of the invention in which mint is used as a fragrance. Thanks to this advantageous characteristic, it becomes possible to give the toothpaste a refreshing effect on the mouth.
Существует также вариант изобретения, в котором в качестве подсластителя применяется агар-агар. Благодаря данной выгодной характеристике появляется возможность повысить лечебный эффект от применения предлагаемой зубной пасты, так как водоросли, дающие агар-агар, необычайно богаты йодом, кальцием, железом и другими ценными веществами и микроэлементами. There is also a variant of the invention in which agar-agar is used as a sweetener. Thanks to this advantageous characteristic, it becomes possible to increase the therapeutic effect of the use of the proposed toothpaste, since the algae that produce agar-agar are unusually rich in iodine, calcium, iron and other valuable substances and trace elements.
Существует вариант изобретения, в котором в качестве освежителя применяется ментол. Благодаря данной выгодной характеристике также появляется возможность придать зубной пасте освежающий полость рта эффект. There is a variant of the invention in which menthol is used as a freshener. This advantageous characteristic also makes it possible to give the toothpaste a refreshing effect on the mouth.
Осуществление изобретения. Implementation of the invention.
При использовании заявленного средства для бросающих курить никотин всасывается через слизистую ротовой полости в процессе чистки зубов (как и при курении), но не загрязняя легкие продуктами горения, а также, не попадая в пищеварение со слюной как при курении (жвачках и таблетках) выполаскивается с пастой. Чистый никотин, полученный организмом через слизистую, понижает потребность в курении, тем самым облегчая состояние курильщика в периоды отказа и помогает восстановить жизнедеятельность, плавно сокращая курение. When using the claimed means for quitting smoking, nicotine is absorbed through the oral mucosa during brushing your teeth (as when smoking), but without polluting the lungs with combustion products, and also, without getting into digestion with saliva, as when smoking (chewing gum and tablets), it is rinsed with paste. Pure nicotine, received by the body through the mucosa, reduces the need for smoking, thereby facilitating the condition of the smoker during periods of withdrawal and helps restore vital activity, gradually reducing smoking.
Промышленная применимость. Industrial applicability.
Заявляемое средство для бросающих курить в виде зубной пасты с содержанием никотина успешно прошло сертификацию в российском центре сертификации на соответствие требованиям стандартов. Кроме того, множество потребителей уже оценило эффект от применения данного средства. The proposed tool for quitting smoking in the form of a toothpaste containing nicotine has successfully passed certification in the Russian certification center for compliance with the requirements of the standards. In addition, many consumers have already appreciated the effect of using this tool.
Данные приведены на основе отзывов курильщиков, рекомендаций врачей и инструкций по применению препаратов. The data are based on the opinions of smokers, recommendations of doctors and instructions for the use of drugs.
Claims
1. Средство для бросающих курить, отличающееся тем, что оно выполнено в виде зубной пасты следующего состава, масс. %: абразивные вещества 70-78%, включающие в себя тальк, влагоудерживающие вещества 10-15%, ароматизаторы и/или отдушка и/или подсластители 5-10%, консерванты и освежители 5-10%, 1. Tool for quitting smoking, characterized in that it is made in the form of a toothpaste of the following composition, wt. %: abrasives 70-78%, including talc, humectants 10-15%, flavors and/or perfume and/or sweeteners 5-10%, preservatives and fresheners 5-10%,
■ ПАВ 1-5%, никотин 1-5%. ■ Surfactant 1-5%, nicotine 1-5%.
2. Средство по п. 1 , отличающееся тем, что в качестве влагоудерживающего вещества применяется глицерин. 2. Means according to claim 1, characterized in that glycerin is used as a moisture-retaining substance.
3. Средство по п. 1 , отличающееся тем, что в качестве консерванта применяется камфора. 3. Means according to claim 1, characterized in that camphor is used as a preservative.
4. Средство по п. 1 , отличающееся тем, что в качестве абразивного вещества применяется карбонат кальция 4. Means according to claim 1, characterized in that calcium carbonate is used as an abrasive
5. Средство по п. 1 , отличающееся тем, что в качестве ПАВ применяется лаурилсульфат натрия 5. Means according to claim 1, characterized in that sodium lauryl sulfate is used as a surfactant
6. Средство по п. 1 , отличающееся тем, что в качестве ароматизатора применяется эфирное масло пачули 6. Means according to claim 1, characterized in that patchouli essential oil is used as a flavoring
7. Средство по п. 1 , отличающееся тем, что в качестве отдушки применяется мята. 7. Means according to claim 1, characterized in that mint is used as a fragrance.
8. Средство по п. 1 , отличающееся тем, что в качестве подсластителя применяется агар-агар 8. Means according to claim 1, characterized in that agar-agar is used as a sweetener
9. Средство по п. 1 , отличающееся тем, что в качестве освежителя применяется ментол. 9. Means according to claim 1, characterized in that menthol is used as a freshener.
9
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US3877468A (en) * | 1970-07-22 | 1975-04-15 | Leo Ab | Chewable tobacco substitute composition |
US4187288A (en) * | 1975-01-28 | 1980-02-05 | Colgate Palmolive Company | Modified abrasive system for dentifrices |
WO1992010147A1 (en) * | 1990-12-14 | 1992-06-25 | Mondre Steven J | Nicotine-containing dental floss |
RU2600443C1 (en) * | 2015-07-17 | 2016-10-20 | Леонид Борисович Потёмкин | Therapeutic tooth paste |
KR101930386B1 (en) * | 2012-05-24 | 2019-03-11 | 주식회사 엘지생활건강 | Adjuvant composition for quit smoking and oral hygiene products containing the same |
EP2435013B1 (en) * | 2009-05-26 | 2019-07-24 | Colgate-Palmolive Company | Dentifrice composition |
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US3877468A (en) * | 1970-07-22 | 1975-04-15 | Leo Ab | Chewable tobacco substitute composition |
US4187288A (en) * | 1975-01-28 | 1980-02-05 | Colgate Palmolive Company | Modified abrasive system for dentifrices |
WO1992010147A1 (en) * | 1990-12-14 | 1992-06-25 | Mondre Steven J | Nicotine-containing dental floss |
EP2435013B1 (en) * | 2009-05-26 | 2019-07-24 | Colgate-Palmolive Company | Dentifrice composition |
KR101930386B1 (en) * | 2012-05-24 | 2019-03-11 | 주식회사 엘지생활건강 | Adjuvant composition for quit smoking and oral hygiene products containing the same |
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