KR101930386B1 - Adjuvant composition for quit smoking and oral hygiene products containing the same - Google Patents

Abstract

The present invention provides a composition for supporting smoking cessation characterized in that the composition contains at least one of a copper salt whose cation is bivalent copper or a zinc salt whose cation is a divalent zinc ion. Further, there is provided an oral hygiene product comprising the composition for smoking cessation assistance. The composition for supporting smoking cessation according to the present invention alters the taste of tobacco, thereby causing an effect of inhibiting the smoking need, thereby contributing to smoking cessation.

Description

TECHNICAL FIELD [0001] The present invention relates to a smoking cessation auxiliary composition and an oral hygiene product containing the same,

The present invention relates to a composition for assisting smoking cessation and an oral hygiene product containing the same.

U.S. Patent Publication No. US5888479 (Mar. 30, 1999)
Currently, smoking cessation aid products are widely used such as tobacco products such as electronic cigarette, gum type, and tooth paste type. In the case of dual nodule products, it is a method of fumigating nicotine, which suppresses the desire for smoking together with smoke, but it continues to inhale nicotine and has a controversy about its harmfulness. In addition, smoking cigarette chewing gum is not the purpose of oral hygiene, but as a way of taking nicotine, it serves to supplement nicotine in chewing form. Thus, in the case of smoking cessation supplements that relieve the addiction of nicotine, it is difficult to provide innovative help for smoking cessation by continuously supplying nicotine.

In addition, non-nicotine-based smoking cessation supplements are products that increase smoking cessation through nerve stimulation by incense, but the effect is very small.

Therefore, it is time to study the new nicotine-free non-nicotine-based products that are highly effective in smoking cessation.

Therefore, a problem to be solved by the present invention is to provide a composition for smoking cessation aids which does not supply nicotine.

Specifically, a problem to be solved by the present invention is to provide a composition for smoking cessation assistance which does not supply nicotine but changes the taste of cigarettes and significantly reduces the need for smoking.

Another object of the present invention is to provide a smoking cessation aid oral hygiene product including the composition for cessation of smoking and having a smoking cessation increasing effect and an oral hygiene effect.

In order to solve the above problem, there is provided a composition for supporting smoking cessation characterized in that the composition contains at least one of a copper salt whose cation is a bivalent copper ion or a zinc salt whose cation is a divalent zinc ion. The present invention also provides an oral hygiene product comprising the composition for smoking cessation assistance. As used in the present invention, 'quitting smoking aid' means helping quit smoking.

Tobacco addiction is caused by the addiction caused by nicotine, but smoking can not be forgotten because of the smell that occurs during smoking and the taste that is felt in the mouth. Therefore, the inventors of the present invention have completed the present invention by studying to change the specific taste of tobacco to prevent the desire for smoking.

The composition for smoking cessation assistance according to the present invention contains at least one of a copper salt and a zinc salt, and the cation of the copper salt and the zinc salt is a copper divalent cation and a zinc divalent cation. The copper salt or zinc salt adheres to the taste buds of the mouth to lower the need for smoking. In addition, the copper salt or zinc salt binds to the tar component contained in the smoke inhaled during smoking, and transmits an abnormal signal to the brain, so that the flavor of the cigarette can be felt rather than the flavor of the tar. In other words, it makes the taste of the cigarette abnormal, thereby inhibiting the desire to smoke.

Preferably, the copper salt is selected from the group consisting of copper gluconate, sodium copper chlorophyllin, cupric sulfate, copper chlorophyll, potassium copper chlorophyllin, Copper sulfate, copper phosphate, copper phosphate and the like, and they are not limited to these, and their single substances or mixtures are used. The zinc salt may be at least one selected from the group consisting of zinc sulfate, zinc gluconate, zinc oxide, Zinc bacitracin, zinc chloride, zinc undecylenate Zinc ricinoleate, Zn acetate, zinc aspartate, and the like, and they are not limited to these, and their single substances or mixtures are used.

Preferably, the total content of the copper salt or the zinc salt is 0.001 to 5% by weight based on the total weight of the composition. More preferably, it is 0.005 to 2.5% by weight. When the content of the substance is less than 0.001% by weight, there is no significant difference in taste during smoking and the effect of smoking cessation is not exhibited. When the content exceeds 5% by weight, the taste of the copper salt or zinc salt itself is too strong, Causing problems such as paralyzing the function of the taste buds.

The composition for smoking cessation assistance according to the present invention may further comprise a substance having a hydroxy group and having a flavor component having an intraoral adhesive property. Specifically, the substance having a hydroxyl group and having an intra-oral adhesion property is Menthol, preferably L-menthol, Eucalytol, Anis oil, anethole, benzyl alchole, ≪ / RTI > and Thymol. More preferably at least one selected from the group including L-menthol, Eucalytol, Anis oil and Thymol.

L-menthol is represented by the general formula (1).

The fragrance ingredient showed adhesive property in the oral cavity due to the hydroxy group contained in each substance, and it could remain in the oral mucosa and taste buds for a long time, thus helping to reduce the smoking need, and contained copper salt or zinc salt during smoking It makes the flavor of cigarettes more active than ever.

More preferably, the component having a hydroxy group and having an intraoral adhesive property is contained in an amount of 0.01 to 5% by weight based on the total weight of the composition for supporting smoking cessation. When the content of the substance is less than 0.01% by weight, the effect of the change of the taste is insignificant because the amount remaining in the oral mucosa and taste buds is insignificant. When the content exceeds 5% by weight, stimulation is caused in the oral cavity, There may be a problem.

The composition for smoking cessation assistance according to the present invention may further comprise a flavoring agent or a sweetening agent. Flavors remain in the mouth and continue to emit fragrance so that the exhilaration can continue. Flavoring agents such as peppermint and spearmint, flavoring agents such as melon, strawberry, orange, or vanillin, wintergreen, methyl salicylate, eugenol, polypropylene glycol and the like can be used. They may be used singly or in combination within a range that does not inhibit them, but the present invention is not limited to these specific types. In general, the flavoring agent may be used in the range of 0.001 to 10% by weight of the total composition weight.

The sweetener makes it possible to overcome the basic taste that the composition for supporting smoking cessation can overcome, and to continue the generation of saliva by continuously providing taste while remaining in the oral cavity. As the sweetening agent, saccharine, sucralose, sugar, xylitol, sorbitol, lactose, mannitol, maltitol, erythritol, aspartame, taurine, saccharin salt and D-tryptophan may be used alone or in combination. May be used singly or in combination within the range not impairing the object, but the present invention is not limited to these specific types. Preferably, in the saccharin salt, saccharin sodium can be used. Generally, sweeteners may be used in the range of 0.001 to 20 wt% of the total weight of the composition.

The composition for smoking cessation assistance according to the present invention may further include a pharmacological effect agent having an effect of preventing tooth decay, preventing gum disease, preventing dental calculus deposition, and whitening. The above-mentioned pharmacologically active agents and the like may be used singly or in combination within the range not impairing the object of the present invention, but the present invention is not limited to the specific kinds shown below.

A compound recognized as a safe substance including fluoride ion can be used for the pharmaceutical agent for the purpose of prevention of tooth decay. As the compound usable as a source of fluorine ions, sodium fluoride, sodium fluorophosphate, tin fluoride, fluorinated amine and the like can be used. One or a mixture of two or more of these sources may be used so that the fluorine content may have a fluorine ion concentration in the range of 850 to 1500 ppm, although the content of fluorine may vary depending on the country.

In addition, a retanning agent may be used for the active agent used for the prevention of tooth decay. The remineralizing agent serves to regenerate and restore hydroxyapatite, a major component of the teeth. The main component of hydroxyapatite is composed of bivalent calcium cations and phosphate anions. Thus, the recrystallization agent can be used to simultaneously supply calcium ions and phosphate ions, or to transfer the chemical equilibrium in the oral cavity to the side where hydroxyapatite is produced. Ion or an anion of phosphoric acid. The materials that provide calcium and phosphorus that can be used as remineralizing agents include, but are not limited to, hydroxyapatite, calcium chloride, casein phosphopeptide, calcium glycerophosphate, sodium phosphate monobasic, sodium phosphate dibasic, , Potassium phosphate dibasic, potassium phosphate dibasic and the like can be used. It is preferable that the remineralizing agent is used in the range of 0.001 to 20% by weight of the whole composition. If the content is less than 0.001% by weight, the effect of re-crystallization is deteriorated. If the content is more than 20% by weight, the properties inherent to the formulation are lost.

The medicinal agent used for the prevention of the periodontal disease prevents the gum disease as well as the gum disease which is progressing through sterilization or anti-inflammatory action against the harmful microorganisms living in the oral cavity. The medicinal active agents used for the prevention of periodontal disease include isopropylmethylphenol, cyclohexidine, cetylpyridinium chloride, triclosan, and xanthorrhizone, which are known as antimicrobial agents, and vitamins and enzymes, amino acids Caproic acid, allantoin and derivatives thereof, and the like can also be used. It is preferable that the medicinal agent for the purpose of preventing the gum disease contains 0.005 to 5% by weight. When the content of the medicinal active substance for prevention of periodontal disease is less than 0.005% by weight, the medicinal effect is difficult to be exhibited. When the content exceeds 5% by weight, the taste of the basic base is changed.

In addition to gum disease, it may contain a pharmaceutical agent for whitening purposes. For example, hydrogen peroxide, carbamide peroxide, calcium peroxide, and the like can be used. In addition, it may contain a pharmaceutical agent for the purpose of inhibiting dental deposition. For example, sodium pyrophosphate, sodium pyrophosphate, potassium pyrophosphate, sodium metaphosphate and the like may be used. In general, a medicinal agent for whitening purposes or a medicinal agent for the purpose of suppressing dental calculus deposition can be used in the range of 0.001 to 10% by weight of the total composition.

The composition for smoking cessation aids according to the present invention can be used in an appropriate amount depending on the kind of the product to be used and the purpose of use, such as an abrasive, a wetting agent, a binder, a foaming agent, an antiseptic agent, an acidity adjusting agent and a brightener. For example, the dentifrice composition of the present invention may contain 20 to 60% by weight of the total composition of calcium hydroxide monohydrate, precipitated silica, calcium carbonate, hydrated alumina, kaolin, NaHCO ₃ , use. As the wetting agent, glycerin, sorbitol, propylene glycol, polyethylene glycol, xylitol, etc. are used singly or in combination of two or more thereof, and 20 to 60% by weight of the total composition is used. As a preservative, paraoxybenzoate and sodium benzoate may be used singly or in combination of two or more. As the acidity adjusting agent, phosphoric acid, sodium phosphate, citric acid, sodium citrate, succinic acid, sodium succinate, tartaric acid and sodium tartrate are used singly or in combination of two or more. The acidity is preferably from 5 to 8. Titanium oxide or the like is used as a brightener and 0.1% to 2% by weight of the whole composition is used.

It is possible to use the composition for smoking cessation according to the present invention to change the taste of the cigarette and to use it as a food for chewing gums and beverages with high smoking cessation effect and drugs such as ointment and patch, Can be used as an oral hygiene product comprising the composition.

The term 'oral hygiene product' of the present invention means all products used for cleansing the oral cavity and includes, for example, toothpaste products, oral cleaning gaggles, oral cleaning spray products, food products such as gum and beverages , Ointment, patch product, and the like, and is not limited to the above-mentioned limited examples. The oral hygiene product containing the composition for supporting smoking cessation according to the present invention not only suppresses the smoking due to a change in the taste of cigarette during smoking but also suppresses the desire for smoking while giving the cleanliness and refreshing feeling of the oral cavity, , Can play a role in further increased smoking cessation aids.

The composition for smoking cessation of the present invention does not supply nicotine and changes the taste of the cigarette, thereby significantly reducing the desire for smoking. In addition, the addition of the fragrance ingredient further induces the taste of the cigarette to further reduce the desire for smoking, thereby helping to quit smoking.

Oral hygiene products containing such compositions for smoking cessation aid the smoking cessation by further increasing the desire for smoking by the effect of oral hygiene.

Hereinafter, embodiments of the present invention will be described in detail to facilitate understanding of the present invention. However, the embodiments according to the present invention can be modified into various other forms, and the scope of the present invention should not be construed as being limited to the following embodiments. Embodiments of the invention are provided to more fully describe the present invention to those skilled in the art.

<Manufacture of Oral Hygiene Products>

Preparation of dentifrice composition

The dentifrice compositions of Examples 1 to 5 and Comparative Example 1 were prepared with the components and composition ratios shown in Table 1 below. Powder components such as pharmacologically active agent, xanthan gum, saccharin, preservative, surfactant, copper salt or zinc salt were completely dispersed in purified water, sorbitol solution and perfume solution, followed by primary mixing. Thereafter, an abrasive such as silica and an active agent were added and mixed under a vacuum to prepare a dentifrice composition.

(weight%) Example 1 Example 2 Example 3 Example 4 Example 5 Comparative Example 1 Precipitated silica 20.00 20.00 20.00 20.00 20.00 20.00 glycerin 10.00 10.00 10.00 10.00 10.00 10.00 Sorbitol solution (70%) 40.00 40.00 40.00 40.00 40.00 40.00 Sodium lauryl sulfate 2.00 2.00 2.00 2.00 2.00 2.00 Copper gluconate 0.01 0.10 1.00 0.1 Zinc gluconate 0.1 0.1 Sodium saccharin 0.20 0.20 0.20 0.20 0.20 0.20 Paraoxybenzoic acid ester 0.15 0.15 0.15 0.15 0.15 0.15 Xanthan gum 1.50 1.50 1.50 1.50 1.50 1.50 Sodium fluoride 0.22 0.22 0.22 0.22 0.22 0.22 Vitamin E 0.20 0.20 0.20 0.20 0.20 0.20 Spices 1.00 1.00 1.00 1.00 1.00 1.00 Purified water 24.72 24.63 23.73 24.63 24.53 24.73

The dentifrice compositions of Examples 5 to 10 were prepared with the components and composition ratios shown in Table 2 below. Powder components such as medicinal agent, xanthan gum, saccharin, preservative, surfactant, copper salt or zinc salt, menthol, thymol, etc. are completely dispersed in a liquid component such as purified water, sorbitol solution, eucalyptol and anise oil, . Thereafter, an abrasive such as silica and an active agent were added and mixed under a vacuum to prepare a dentifrice composition.

(weight%) Example 6 Example 7 Example 8 Example 9 Example 10 Example 5 Precipitated silica 20.00 20.00 20.00 20.00 20.00 20.00 glycerin 10.00 10.00 10.00 10.00 10.00 10.00 Sorbitol solution (70%) 40.00 40.00 40.00 40.00 40.00 40.00 Sodium lauryl sulfate 2.00 2.00 2.00 2.00 2.00 2.00 Copper gluconate 0.1 0.1 0.1 0.1 0.1 0.1 Zinc gluconate 0.1 0.1 0.1 0.1 0.1 menthol 0.5 0.5 Eucalyptol 0.5 Anise oil 0.5 Thymol 0.5 Sodium saccharin 0.20 0.20 0.20 0.20 0.20 0.20 Paraoxybenzoic acid ester 0.15 0.15 0.15 0.15 0.15 0.15 Xanthan gum 1.50 1.50 1.50 1.50 1.50 1.50 Sodium fluoride 0.22 0.22 0.22 0.22 0.22 0.22 Vitamin E 0.20 0.20 0.20 0.20 0.20 0.20 Spices 1.00 1.00 1.00 1.00 1.00 1.00 Purified water 24.13 24.03 24.03 24.03 24.03 24.53

Mouthwash  Preparation of composition

The oral mucilaginous compositions of Examples 11 to 15 and Comparative Example 2 were prepared with the components and composition ratios shown in Table 3 below. The two kinds of solutions prepared by dissolving glycerin, a sweetener, copper gluconate or zinc gluconate in purified water and dissolving the components for solubilizing such as surfactant, fragrance, menthol, eucalyptol, anise oil and thymol into ethanol, To prepare an oral mouthwash solution composition.

(weight %) Example 11 Example 12 Example 13 Example 14 Example 15 Comparative Example 2 ethanol 5.00 5.00 5.00 5.00 5.00 5.00 menthol 0.10 Eucalyptol 0.10 Thymol 0.10 Anise oil 0.10 Spices 0.50 0.50 0.50 0.50 0.50 0.50 Paraoxybenzoic acid ester 0.10 0.10 0.10 0.10 0.10 0.10 Sodium saccharin 0.02 0.02 0.02 0.02 0.02 0.02 Copper gluconate 0.01 0.01 0.01 0.01 0.01 Zinc gluconate 0.01 0.01 0.01 0.01 0.01 Sodium fluoride 0.02 0.02 0.02 0.02 0.02 0.02 Cetylpyridinium chloride 0.10 0.10 0.10 0.10 0.10 0.10 glycerin 10.00 10.00 10.00 10.00 10.00 10.00 Purified water 84.14 84.14 84.14 84.14 84.24 84.26

Manufacture of Oral Spray Composition

The oral spray compositions of Examples 16 to 20 and Comparative Example 3 were prepared with the components and composition ratios shown in Table 4 below. The two kinds of solutions prepared by dissolving glycerin, a sweetener, copper gluconate or zinc gluconate in purified water and dissolving the components for solubilizing such as surfactant, fragrance, menthol, eucalyptol, anise oil and thymol into ethanol, To prepare an oral spray composition.

(weight %) Example 16 Example 17 Example 18 Example 19 Example 20 Comparative Example 3 ethanol 45.00 45.00 45.00 45.00 45.00 45.00 menthol 1.00 Eucalyptol 1.00 Thymol 1.00 Anise oil 1.00 Spices 2.50 2.50 2.50 2.50 2.50 2.50 Sodium saccharin 0.20 0.20 0.20 0.20 0.20 0.20 Copper gluconate 0.02 0.02 0.02 0.02 0.02 Zinc gluconate 0.02 0.02 0.02 0.02 Sodium fluoride 0.02 0.02 0.02 0.02 0.02 0.02 Kurukuma Zantori Freedom 0.01 0.01 0.01 0.01 0.01 0.01 glycerin 10.00 10.00 10.00 10.00 10.00 10.00 Purified water 41.23 41.23 41.23 41.23 42.25 42.27

&Lt; Evaluation of smoking inhibition effect &

The following questionnaire was conducted for the smoking inhibition test of Examples 1 to 4 and Comparative Examples 1 to 4.

Decrease rate of smoking needs after using oral hygiene products

The questionnaire was applied to 10 smokers in their 20s to 40s for the reduction of smoking needs and taste changes after using oral hygiene products. The evaluation was scored by scoring 5 points on the scale and 5 points on the high score. The results are shown in Tables 5 to 7.

Item of questionnaire

* Do you have a desire to smoke after using oral hygiene products?

1 point - I just want to smoke ~

5 points - The need for smoking was significantly lowered.

* Does the cigarette taste change after use of the oral hygiene product to suppress smoking need?

1 point - no change in taste and just want to smoke ~

5 points - The taste of smoking was bad and the desire for smoking was significantly lowered.

Tooth depression effect of smoking desire

The toothpaste according to Examples 1 to 10 and Comparative Example 1 was adjusted to be used for 1 minute or more before smoking and the questionnaire was evaluated. The results are shown in Table 5.

Question 1 Question 2 Example 1 3.15 ± 0.45 3.16 ± 0.36 Example 2 3.25 0.35 3.43 + - 0.51 Example 3 3.94 + - 0.92 3.95 + 0.81 Example 4 3.21 + - 0.44 3.25 ± 0.53 Example 5 3.31 ± 0.51 3.49 ± 0.61 Example 6 3.48 ± 0.56 3.51 + - 0.73 Example 7 3.84 0.76 3.91 ± 0.86 Example 8 3.54 + - 0.63 3.64 ± 0.72 Example 9 3.46 ± 0.82 3.65 ± 0.75 Example 10 3.56 ± 0.71 3.85 ± 0.69 Comparative Example 1 1.51 + - 0.45 1.21 0.33

Examples 1 to 5 are dentifrice compositions containing at least one of a copper salt and a zinc salt, and Examples 6 to 10 are dentifrice compositions further comprising one of menthol, eucalyptol, thymol and anise oil.

As a result of using the toothpaste according to the present invention, it was found that the need for smoking was significantly reduced in smokers using Examples 1 to 10 as compared with Comparative Example 1 after use. It was also found that the smoking needs decreased as the content of copper gluconate of Examples 1 to 3 was decreased with the increase in the content of the smoking cigarette, and even when zinc gluconate was used as in Example 4, And a decrease in desire was confirmed.

Examples 6 to 10 containing menthol, eucalyptol, anise oil, and thymol, which were used to increase the residual force in each oral cavity, had higher smoking needs than those of Examples 1 to 5 using only copper gluconate or zinc gluconate . &Lt; / RTI &gt; That is, it can be confirmed that the four kinds of fragrance components are caused by the synergistic action to suppress the smoking need.

Mouth Gaggle  Smoking cessation suppression effect

10 to 15 mL of oral mucilages according to Examples 11 to 15 and Comparative Example 2 were adjusted to be pre-smoking, and then the questionnaire was evaluated. The results are shown in Table 6.

Question 1 Question 2 Example 11 4.10 ± 0.91 4.23 ± 0.83 Example 12 4.01 + - 0.85 4.06 ± 0.77 Example 13 3.86 ± 0.69 3.89 ± 0.79 Example 14 3.98 + 0.87 3.97 + 0.78 Example 15 3.53 + - 0.68 3.78 ± 0.83 Comparative Example 2 1.21 ± 0.15 1.11 + 0.06

Example 15 is a mouthwash solution containing a copper salt and a zinc salt, and Examples 11 to 14 are oral cooling agents further containing one of menthol, eucalyptol, thymol and anise oil.

The use of menthol, eucalyptol, anise oil, menthol, or the like together with copper gluconate or zinc gluconate at the same time, the lowering of the smoking need was much higher than that of Comparative Example 2, It was confirmed that the smoking cessation rate was higher than that of Example 15, Since the mouthwash liquid is used more than toothpaste, the concentration of residue in the taste buds is higher than that of toothpaste.

Effect of Oral Spray on Smoking Needs

The oral sprays according to Examples 16 to 20 and Comparative Example 3 were sprayed once or twice before oral smoking, and the questionnaire evaluation was carried out. The results are shown in Table 7.

Question 1 Question 2 Example 16 4.56 ± 0.85 4.59 ± 0.93 Example 17 4.38 + 0.76 4.49 ± 0.68 Example 18 4.48 ± 0.91 4.52 + - 0.82 Example 19 4.43 ± 0.88 4.51 ± 0.84 Example 20 4.10 ± 0.89 4.21 + - 0.93 Comparative Example 3 2.01 ± 0.32 2.13 + - 0.41

Example 20 is an oral spray containing a copper salt, Examples 16 to 19 is a mouth spray further containing one of menthol, eucalyptol, thymol and anise oil in addition to a copper salt and a zinc salt.

It was confirmed that the use of menthol, eucalyptol, anise oil, menthol, etc., together with copper gluconate and zinc gluconate, as in Examples 16 to 19, It was confirmed that even when only the copper gluconate was used without containing the above four components, the rate of inhibition of smoking was high. In addition, toothpaste and mouthwash liquid are used for later washing. However, since oral spray is used from sprinkling to natural exhaustion, the concentration remaining in the taste buds is higher than other oral hygiene products.

Claims (8)

Copper gluconate and zinc gluconate in an amount of 0.001 to 0.1% by weight of the total composition and containing 0.01 to 1% by weight of menthol as a flavor ingredient having a hydroxy group and having an intraoral adhesive property, Wherein the composition for smoking cessation is a composition for smoking cessation. delete delete delete delete delete delete An oral hygiene product comprising the composition for supporting smoking cessation according to claim 1.