WO2023087410A1 - 一种含有甲氨基阿维菌素B2a苯甲酸盐的杀虫组合物 - Google Patents

一种含有甲氨基阿维菌素B2a苯甲酸盐的杀虫组合物 Download PDF

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WO2023087410A1
WO2023087410A1 PCT/CN2021/134961 CN2021134961W WO2023087410A1 WO 2023087410 A1 WO2023087410 A1 WO 2023087410A1 CN 2021134961 W CN2021134961 W CN 2021134961W WO 2023087410 A1 WO2023087410 A1 WO 2023087410A1
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benzoate
emamectin
insecticidal composition
nerolidol
weight ratio
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PCT/CN2021/134961
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English (en)
French (fr)
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张少飞
张文树
李宏敏
陈海涛
王澍春
丁新吉
柴方堃
贾成国
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河北威远生物化工有限公司
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02—Acyclic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
    • A01N43/08—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings with oxygen as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
    • A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles

Definitions

  • the invention belongs to the technical field of pesticide preparation, in particular to an insecticidal composition containing emamectin B2a benzoate.
  • Plant parasitic nematodes are a class of pathogenic microorganisms that are extremely harmful. They have a wide range of distribution, a variety of species, and strong environmental adaptability, which seriously restricts the development of agricultural economy.
  • Emamectin B2a benzoate is a class of macrolide disaccharide insecticides with insecticidal, acaricidal and aphidicidal activities. This product has a high control effect on various agricultural pests, especially has super high insecticidal activity on aphids and parasites, and has been widely used.
  • the present invention provides an insecticidal composition which can enhance the efficacy of the insecticide and reduce the dosage of the insecticide.
  • An insecticidal composition containing emamectin B2a benzoate comprising component A and component B, wherein component A is emamectin B2a benzoate, and component B is selected from One of sulfene sulfone, flufenapyramide, trifluramide, trifluridin, oligosaccharin, and nerolidol.
  • the weight ratio of component A to component B of the pesticidal composition containing emamectin B2a benzoate is 1:60-60:1.
  • the weight ratio of emamectin B2a benzoate to sulfone is 30:1-1:30;
  • the weight ratio of emamectin B2a benzoate to flufenapyramide is 30:1-1:30;
  • the weight ratio of emamectin B2a benzoate to triflumidamide is 60:1-1:20;
  • the weight ratio of emamectin B2a benzoate to trifluridinate is 20:1-1:20;
  • the weight ratio of emamectin B2a benzoate to amino oligosaccharin is 20:1-1:20;
  • the weight ratio of emamectin B2a benzoate to nerolidol is 30:1-1:20.
  • the weight ratio of emamectin B2a benzoate to nerolidol is 2:1-1:10.
  • the dosage form of the pesticidal composition is one of microemulsion, emulsifiable concentrate, water emulsion, suspoemulsion, oil suspension and granule.
  • the further improvement of the technical solution of the present invention lies in that: the application method is root irrigation, spraying, spreading, furrow application, hole application or seed dressing.
  • the further improvement of the technical solution of the present invention lies in: the insecticidal composition is used for preventing and controlling plant nematodes and underground pests, leek maggots.
  • the insecticidal composition provided by the invention through the compounding of emamectin B2a benzoate and other medicaments, has significantly improved the control effect on plant nematodes and leek maggots, and the insecticidal composition
  • the mechanisms of action of the active ingredients are different from each other, which reduces the single selection pressure on nematodes, and is beneficial to overcome the generation of nematode resistance and delay the development of nematode resistance.
  • a nematocidal composition containing emamectin B2a benzoate is microemulsion, prepared according to the following process: take emamectin B2a benzoate 3.34%, nerolidol 1.66% %, dimethylacetamide 5%, diethylene glycol monoethyl ether 15%, propylene glycol 5%, oleic acid polyoxyethylene ether phosphate 15%, calcium dodecylbenzenesulfonate 5%, after mixing and stirring evenly, add Make up 100% with deionized water and stir evenly to obtain 5% emamectin B2a benzoate ⁇ nerolidol microemulsion.
  • the nerolidol in this embodiment can be replaced by any one of fluorine sulfone, flufenapyramide, triflumid, trifluorocystid, and amino oligosaccharin to form a new embodiment .
  • a nematocidal composition containing emamectin B2a benzoate is water emulsion, prepared according to the following process: take emamectin B2a benzoate 3.33%, nerolidol 6.67% %, 5# white oil 4%, diethylene glycol butyl ether acetate 12%, N,N-dimethyldecylamide 15%, octylphenyl polyoxyethylene ether 4%, isomeric tridecyl alcohol Vinyl ether 5%, calcium dodecylbenzenesulfonate 2%, after mixing and stirring evenly, add deionized water to make up 100%, obtain 10% emamectin B2a benzoate orange after high-speed shearing Flower tertiary alcohol water emulsion.
  • the nerolidol in this embodiment can be replaced by any one of fluorine sulfone, flufenapyramide, triflumid, trifluorocystid, and amino oligosaccharin to form a new embodiment .
  • the nerolidol in this embodiment can be replaced by any one of fluorine sulfone, flufenapyramide, trifluoroimidinamide, trifluorocystid, and amino oligosaccharin to form a new embodiment .
  • a nematocidal composition containing emamectin B2a benzoate is an oil suspension comprising the following components: emamectin B2a benzoate 9%, nerolidol 72% , glyceryl monostearate 6%, castor oil polyoxyethylene ether 2%, polyacrylate 1.5%, organic bentonite 1%, methyl oleate to make up.
  • the components were mixed uniformly and ground by a sand mill to obtain 81% emamectin B2a benzoate ⁇ nerolidol oil suspension.
  • the above raw materials are uniformly mixed in a mixing tank, extruded, granulated, dried, and sieved to obtain 15.4% emamectin B2a benzoate ⁇ nerolidol granules.
  • the nerolidol in this embodiment can be replaced by any one of fluorine sulfone, flufenapyramide, triflumid, trifluorocystid, and amino oligosaccharin to form a new embodiment .
  • Example 4 The difference between this example and Example 4 is that the proportion of emamectin B2a benzoate in the components is 3.6%, the proportion of nerolidol is 36.4%, and the remaining components and their proportions are the same as those in the example 4 is the same.
  • Example 2 The difference between this comparative example and Example 2 is that the proportion of emamectin B2a benzoate in the components is 10%, and nerolidol is not included at the same time, and the remaining components and their proportions are the same as in Example 2 .
  • Example 2 The difference between this comparative example and Example 2 is that the proportion of nerolidol in the components is 10%, and emamectin B2a benzoate is not included at the same time, and the remaining components and their proportions are the same as in Example 2 .
  • the synergistic effect of drug mixture is evaluated according to the co-toxicity coefficient (CTC), that is, CTC ⁇ 80 is synergistic antagonism, 80 ⁇ CTC ⁇ 120 is synergistic antagonism, and CTC ⁇ 120 is synergistic effect.
  • CTC co-toxicity coefficient
  • Drug effect example 1 Combined toxicity of emamectin B2a benzoate and fluoroacryloyl sulfone
  • A is Emamectin B2a Benzoate
  • B is Fluoroylsulfone
  • Drug effect example 2 Combined toxicity of emamectin B2a benzoate and flufenapyramide
  • A is emamectin B2a benzoate
  • B is flufenapyramide
  • Drug effect example 3 The combined toxicity of emamectin B2a benzoate and trifluoropyridinamide
  • A is emamectin B2a benzoate
  • B is triflumidazolamide
  • Drug effect example 4 The combined toxicity of emamectin B2a benzoate and triflucid
  • A is emamectin B2a benzoate
  • B is trifluorospin
  • Drug effect example 5 Combined toxicity of emamectin B2a benzoate and amino oligosaccharin
  • A is emamectin B2a benzoate
  • B is amino oligosaccharin
  • the indoor toxicity test method is the same as the above method. Because nerolidol is not a pesticide ingredient, it has no activity against root-knot nematode incognita. Therefore, the synergy ratio SR is used to evaluate the synergistic effect of the two.
  • the test results are shown in Table 6.
  • Synergistic ratio SR LC50 value of drug used alone / LC50 value of combined drug and synergistic adjuvant
  • A is emamectin B2a benzoate
  • B is nerolidol
  • the LC50 of the mixture in the table refers to the total mass concentration of A and B
  • nerolidol itself has almost no insecticidal effect on root-knot nematode incognita, but nerolidol can significantly enhance the toxicity of emamectin B2a benzoate to root-knot nematode incognita.
  • the synergy ratio SR is greater than 1; and when the weight ratio of the two is in the interval of 2:1-1:10, the synergy ratio SR even exceeds 3, of which When the weight ratio of the two is 1:2, the synergistic ratio SR reaches the maximum value of 4.76.
  • Stomach poison contact method was used to target the 3rd instar larvae of chive maggots, and emamectin B2a benzoate and nerolidol were used as test agents, and the agents were prepared into liquids with different concentrations.
  • Spread the clean filter paper on a petri dish with a diameter of 8 cm and agar underneath add 1 mL of the prepared medicinal solution dropwise on the filter paper, cut the pseudostem of leek into small pieces of about 2 cm, and place them in different doses of medicinal liquid.
  • A is emamectin B2a benzoate
  • B is nerolidol
  • the LC50 of the mixture in the table refers to the total mass concentration of A and B
  • nerolidol itself has almost no insecticidal effect on leek maggots, but nerolidol can significantly enhance the toxicity of emamectin B2a benzoate to leek maggots.
  • the synergy ratio SR is greater than 1; and when the weight ratio of the two is in the interval of 2:1-1:10, the synergy ratio SR even exceeds 2, of which When the weight ratio of the two is 1:2, the synergistic ratio SR reaches the maximum value of 2.75.
  • the experiment was conducted in a tomato plantation shed in Dingzhou, Baoding City, Hebei province.
  • the soil was loamy, with good soil moisture, medium fertility, and serious damage from root-knot nematodes.
  • a total of 9 treatments were set up in the experiment (the nematode hazards in the treatment area were basically uniform and the ecological environment was the same), with clean water as the control, and each treatment was repeated 4 times, and each treatment was randomly arranged.
  • the area of each plot is about 15m 2 , and 40 tomatoes with normal growth are planted in each plot.
  • the planting time is August 20, 2020. Use the method of root irrigation or spraying to test the medicine.
  • Root irrigation treatment is carried out on the day of transplantation, and the medicine is diluted with water, and each seedling is treated with 400ml of the diluted solution; the spraying treatment is carried out before transplantation, and the granule and fine soil are mixed at a rate of 15kg/mu.
  • Poisonous soil after being converted into the amount of the community, is evenly spread in the community, and mixed with nails and rakes, and the depth of the agent into the soil is about 15cm. After sprinkling the poisonous soil, the tomato seedlings are transplanted and planted.
  • the survey method was carried out according to the guidelines for field efficacy tests of pesticides.
  • Grade 0 no visible nodules or egg masses
  • Grade 1 The total length of nodules accounts for 1%-24% of the total root length
  • Grade 2 The total length of nodules accounts for 25%-49% of the total root length
  • Grade 3 The total length of nodules accounts for 50%-74% of the total root length
  • Grade 4 The total length of nodules accounts for 75%-100% of the total root length
  • Control effect (%) (1-treatment disease index/control disease index) ⁇ 100.
  • Example 3 1:4 400 13.4 82.04
  • Example 4 1:6 400 10.8 85.52
  • Example 5 1:8 400 12.6 83.11
  • Example 6 1:10 400 11.5 84.58 Comparative example 1 - 400 26.7 64.21 Comparative example 2 - 400 68.7 7.91 CK - - 74.6 -
  • the effective dosage is the total amount of aminobamectin B2a benzoate and nerolidol
  • the test site is convenient for drainage and irrigation, the soil fertility is medium, and the cucumber variety is Lvying 06-8. Seedlings were grown under shade in greenhouses, and after 10 days of seedling age, they were planted in Longshang, with a row spacing of 0.45m and a plant spacing of 0.28m.
  • the area of each plot is about 15m 2 , and 60 cucumbers with normal growth are planted in each plot.
  • the planting time is July 30, 2020.
  • Example 1 2:1 450 17.2 78.82
  • Example 2 1:2 450 19.6 75.86
  • Example 3 1:4 450 15.4 81.03
  • Example 4 1:6 450 10.4 87.19
  • Example 5 1:8 450 12.9 84.11
  • Example 6 1:10 450 13.7 83.13 Comparative example 1 - 450 35.6 56.16 Comparative example 2 - 450 77.6 4.43 CK - - 81.2 -
  • the effective dosage is the total amount of emamectin B2a benzoate and nerolidol
  • Drug effect example 10 Field control effect of emamectin B2a benzoate and nerolidol mixed preparation on leek maggot
  • the land is planted with leeks all year round.
  • the variety of leeks is Pingjiu No. 2, and leek maggots are seriously harmful.
  • the test site is convenient for drainage and irrigation, and the soil fertility is medium.
  • the area of each plot is about 30m 2 .
  • There are 9 treatments in total in the test (the harm of leek maggots in the treatment area is basically uniform, and the ecological environment is the same). Clean water is used as a control. Each treatment is repeated 4 times, and each treatment is randomized. arrange.
  • the spraying time is September 12, 2020, the spraying method is fixed-point spraying, and the sprayer is WS-18D knapsack electric sprayer. Dilute the agent with 15L of water and pour it into the sprayer barrel, and use the nozzle to spray the leek stubble one by one, spraying 25mL per hole. Immediately after the fixed-point spraying, the test plot was irrigated with large water, and the water depth was 4-5cm.
  • the survey of the number of damaged plants took 10 mounds in each of the two rows in the center of the plot, counted the number of healthy plants and the number of damaged plants, and investigated the number of surviving populations. Dig out 5 mounds of leeks in the center of the plot, and count the number of living maggots inside and outside the bulbs.
  • the control effect and plant protection effect were calculated according to the following formulas:
  • Control effect (%) (number of insect population in control area-number of insect population in treatment area)/number of insect population in control area*100
  • Plant protection effect (%) (the rate of injured plants in the control area - the storage rate of injured plants in the treatment area) / the rate of injured plants in the blank control area * 100
  • the effective dosage is the total amount of emamectin B2a benzoate and nerolidol

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Abstract

涉及一种含有甲氨基阿维菌素B2a苯甲酸盐的杀虫组合物，属于农药制备技术领域。杀虫组合物含有组分A和组分B。其中组分A为甲氨基阿维菌素B2a苯甲酸盐，组分B选自氟烯线砜、氟唑菌酰羟胺、三氟咪啶酰胺、三氟杀线酯、氨基寡糖素、橙花叔醇中的一种。该杀虫组合物显著提高了对植物线虫的防治效果，降低了对线虫的单一选择压力，有利于克服线虫抗性产生和延缓线虫抗性的产生速度。

Description

一种含有甲氨基阿维菌素B2a苯甲酸盐的杀虫组合物 技术领域
本发明属于农药的制备技术领域，尤其涉及一种含有甲氨基阿维菌素B2a苯甲酸盐的杀虫组合物。
背景技术
植物寄生线虫是一类危害极大的病原微生物，其分布范围广、种类繁多、环境适应能力强，严重制约了农业经济的发展。
因此，为了有效防治病害，保护环境生态安全，在有效控制线虫危害的同时，减少农药用量，降低农药残留，研发设计一种对植物线虫杀灭活性好且持效性久的无公害生物农药，具有十分重要的意义。
甲氨基阿维菌素B2a苯甲酸盐是一类具有杀虫、杀螨、杀蚜虫活性大环内酯双糖类杀虫剂。该产品对多种农业害虫具有较高的防治效果，尤其是对蚜虫、寄生虫具有超高的杀虫活性，已经推广应用。申请人在研究中发现，甲氨基阿维菌素B2a苯甲酸盐对线虫具有较高的活性。与其他杀线虫剂按照特定比例复配后，增效作用极为显著。因此，有必要对甲氨基阿维菌素B2a苯甲酸盐的复配剂进行研究，增强其药效，延长有效药力，减少用药量。
发明内容
针对现有技术中杀虫组合物毒性高、杀虫效果不够理想、持效性差的问题，本发明提供一种杀虫组合物，能够增强药效，减少用药量。
为解决上述技术问题，本发明提供的技术方案是：
一种含有甲氨基阿维菌素B2a苯甲酸盐的杀虫组合物，包括组分A和组分B，其中组分A为甲氨基阿维菌素B2a苯甲酸盐，组分B选自氟烯线砜、氟唑菌酰羟胺、三氟咪啶酰胺、三氟杀线酯、氨基寡糖素、橙花叔醇中的一种。
本发明技术方案的进一步改进在于：含有甲氨基阿维菌素B2a苯甲酸盐的杀虫组合物的组分A与组分B的重量比为1:60-60:1。
本发明技术方案的进一步改进在于：
甲氨基阿维菌素B2a苯甲酸盐与氟烯线砜的重量比为30:1-1:30；
甲氨基阿维菌素B2a苯甲酸盐与氟唑菌酰羟胺的重量比为30:1-1:30；
甲氨基阿维菌素B2a苯甲酸盐与三氟咪啶酰胺的重量比为60:1-1:20；
甲氨基阿维菌素B2a苯甲酸盐与三氟杀线酯的重量比为20:1-1:20；
甲氨基阿维菌素B2a苯甲酸盐与氨基寡糖素的重量比为20:1-1:20；
甲氨基阿维菌素B2a苯甲酸盐与橙花叔醇的重量比为30:1-1:20。
本发明技术方案的进一步改进在于：甲氨基阿维菌素B2a苯甲酸盐与橙花叔醇的重量比为2:1-1:10。
本发明技术方案的进一步改进在于：所述杀虫组合物的剂型是微乳剂、乳油、水乳剂、悬浮乳剂、油悬浮剂、颗粒剂中的一种。
本发明技术方案的进一步改进在于：施用方式为灌根、喷雾、撒施、沟施、穴施或拌种。
本发明技术方案的进一步改进在于：所述的杀虫组合物，用于防治植物线虫和地下害虫韭蛆。
由于采用了上述技术方案，本发明取得的技术效果如下：
对于现有技术，本发明提供的杀虫组合物，通过甲氨基阿维菌素B2a苯甲酸盐与其他药剂的复配，显著提高了对植物线虫和韭蛆的防治效果，杀虫组合物中有效成分的作用机制互不相同，降低了对线虫的单一选择压力，有利于克服线虫抗性产生和延缓线虫抗性的产生速度。
具体实施方式
为了使本发明的目的、技术方案及优点更加清楚明白，以下结合实施例，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限定本发明。
实施例1
一种含有甲氨基阿维菌素B2a苯甲酸盐的杀线虫组合物，剂型为微乳剂，按以下过程配制：取甲氨基阿维菌素B2a苯甲酸盐3.34％，橙花叔醇1.66％，二甲基乙酰胺5％，二甘醇单乙醚15％，丙二醇5％，油酸聚氧乙烯醚磷酸酯15％，十二烷基苯磺酸钙5％，混合搅拌均匀后，加入去离子水补足100％并搅拌均匀，得到5％甲氨基阿维菌素B2a苯甲酸盐·橙花叔醇微乳剂。
本实施例中的橙花叔醇可替换为氟烯线砜、氟唑菌酰羟胺、三氟咪啶酰胺、三氟杀线酯、氨基寡糖素中的任一种，形成新的实施例。
实施例2
一种含有甲氨基阿维菌素B2a苯甲酸盐的杀线虫组合物，剂型为水乳剂，按以下过程配制：取甲氨基阿维菌素B2a苯甲酸盐3.33％，橙花叔醇6.67％，5#白油4％，二乙二醇丁醚醋酸酯12％，N,N-二甲基癸酰胺15％，辛基苯基聚氧乙烯醚4％，异构十三醇聚氧乙烯醚5％，十二烷基苯磺酸钙2％，混合搅拌均匀后，加入去离子水补足100％，经高速剪切后得到10％甲氨基阿维菌素B2a苯甲酸盐·橙花叔醇水乳剂。
本实施例中的橙花叔醇可替换为氟烯线砜、氟唑菌酰羟胺、三氟咪啶酰胺、三氟杀线酯、氨基寡糖素中的任一种，形成新的实施例。
实施例3
一种含有甲氨基阿维菌素B2a苯甲酸盐的杀线虫组合物，剂型为悬浮乳剂，按以下过程配制：取橙花叔醇16％，Solvesso 150溶剂油6％，N,N-二甲基癸酰胺9％，混合搅拌均匀，作为油相；取甲氨基阿维菌素B2a苯甲酸盐4％，脂肪醇聚氧乙烯醚磷酸酯三乙醇胺盐酸盐4％，羟基聚环氧乙烷嵌段共聚物2％，丙二醇5％，黄原胶0.2％，去离子水补足100％，混合均匀后经砂磨机研磨，作为水相。搅拌条件下，将油相缓慢加入到水相中，经高速剪切后得到20％甲氨基阿维菌素B2a苯甲酸盐·橙花叔醇悬浮乳剂。
本实施例中的橙花叔醇可替换为氟烯线砜、氟唑菌酰羟胺、三氟咪啶酰胺、 三氟杀线酯、氨基寡糖素中的任一种，形成新的实施例。
实施例4
一种含有甲氨基阿维菌素B2a苯甲酸盐的杀线虫组合物，剂型为乳油，包括以下组分：甲氨基阿维菌素B2a苯甲酸盐5.7％，橙花叔醇34.3％，二甲基乙酰胺15％，蓖麻油聚氧乙烯醚12％，油酸酰胺聚氧乙烯醚磷酸酯8％，蓖麻油12％，N,N-二甲基癸酰胺补齐。各组分混合搅拌均匀，得到40％甲氨基阿维菌素B2a苯甲酸盐·橙花叔醇乳油。
实施例5
一种含有甲氨基阿维菌素B2a苯甲酸盐的杀线虫组合物，剂型为油悬浮剂包括以下组分：甲氨基阿维菌素B2a苯甲酸盐9％，橙花叔醇72％，单硬脂酸甘油酯6％，蓖麻油聚氧乙烯醚2％，聚丙烯酸酯1.5％，有机膨润土1％，油酸甲酯补齐。各组分混合均匀后经砂磨机研磨，得到81％甲氨基阿维菌素B2a苯甲酸盐·橙花叔醇油悬浮剂。
实施例6
一种含有甲氨基阿维菌素B2a苯甲酸盐的杀线虫组合物，剂型为颗粒剂，包括以下组分：甲氨基阿维菌素B2a苯甲酸盐1.4％，橙花叔醇14％，烷基酚聚氧乙烯基醚磺酸盐6％，聚乙烯醇0.1％，聚醋酸乙烯酯1％，白土15％，凹凸棒土补齐。上述原料在混合缸中混合均匀，经过挤压、造粒、干燥，并经筛分得到15.4％甲氨基阿维菌素B2a苯甲酸盐·橙花叔醇颗粒剂。
本实施例中的橙花叔醇可替换为氟烯线砜、氟唑菌酰羟胺、三氟咪啶酰胺、三氟杀线酯、氨基寡糖素中的任一种，形成新的实施例。
实施例7
本实施例与实施例4的区别为组分中甲氨基阿维菌素B2a苯甲酸盐占比为3.6％，橙花叔醇占比为36.4％，其余组分及其占比和实施例4相同。
对比例1
本对比例和实施例2的区别为组分中甲氨基阿维菌素B2a苯甲酸盐占比为10％，同时不包括橙花叔醇，其余组分及其占比和实施例2相同。
对比例2
本对比例和实施例2的区别为组分中橙花叔醇占比为10％，同时不包括甲氨基阿维菌素B2a苯甲酸盐，其余组分及其占比和实施例2相同。
以上实施例仅为本发明包含实施例的部分代表，可根据实际复配药剂，调整实施例的有效成分，含量，助剂种类以及用量，获得新的实施例。
室内毒力测定
按照孙云沛法，根据共毒系数(CTC)来评价药剂混用的协同作用，即CTC≤80为协同拮抗作用，80＜CTC＜120为协同拮抗作用，CTC≥120为协同增效作用。实测毒力指数(ATI)＝(标准药剂的EC50/供试药剂的EC50)×100；理论毒力指数TTI＝A药剂的毒力指数×混剂中A药剂的百分含量+B药剂的毒力指数×混剂中B药剂的百分含量；共毒系数(CTC)＝[混剂实测毒力指数(ATI)/混剂理论毒力指数(TTI)]×100。
对南方根节线虫进行了室内联合毒力测定试验。采用直接触杀法(万树青，1994)，在每个经高温灭菌的培养皿中加入1ml 200头/ml左右新孵化的南方根节线虫二龄幼虫悬浮液，分别加入1ml不同浓度的稀释液，对照中加入1ml无菌水，每个处理重复3次，置于25℃恒温培养箱中培养。24h后，在显微镜下观察线虫死亡情况，统计死亡数，计算死亡率。通过毒力回归方程v＝a+bx计算，并进行卡方检验。以机值分析法求出供试药剂的致死中浓LC 50及其95％置信限，具体数据见以下药效实施例。
药效实施例1甲氨基阿维菌素B2a苯甲酸盐与氟烯酰砜的联合毒力
表1
Figure PCTCN2021134961-appb-000001
Figure PCTCN2021134961-appb-000002
备注：A为甲氨基阿维菌素B2a苯甲酸盐，B为氟烯酰砜
表1结果表明，甲氨基阿维菌素B2a苯甲酸盐与氟烯酰砜的重量比在30:1-1:30区间内，共毒系数均大于120，部分比例甚至超过150，表明二者增效明显。
药效实施例2甲氨基阿维菌素B2a苯甲酸盐与氟唑菌酰羟胺的联合毒力
表2
Figure PCTCN2021134961-appb-000003
备注：A为甲氨基阿维菌素B2a苯甲酸盐，B为氟唑菌酰羟胺
表2结果表明，甲氨基阿维菌素B2a苯甲酸盐与氟唑菌酰羟胺的重量比在30:1-1:30区间内，共毒系数均大于120，表明二者增效明显。
药效实施例3甲氨基阿维菌素B2a苯甲酸盐与三氟吡啶酰胺的联合毒力
表3
Figure PCTCN2021134961-appb-000004
备注：A为甲氨基阿维菌素B2a苯甲酸盐，B为三氟咪啶酰胺
表3结果表明，甲氨基阿维菌素B2a苯甲酸盐与三氟吡啶酰胺的重量比在60:1-1:20区间内，共毒系数均大于120，表明二者增效明显。
药效实施例4甲氨基阿维菌素B2a苯甲酸盐与三氟杀线酯的联合毒力
表4
Figure PCTCN2021134961-appb-000005
Figure PCTCN2021134961-appb-000006
备注：A为甲氨基阿维菌素B2a苯甲酸盐，B为三氟杀线酯
表4结果表明，甲氨基阿维菌素B2a苯甲酸盐与三氟杀线酯的重量比在20:1-1:20区间内，共毒系数均大于120，表明二者增效明显。
药效实施例5甲氨基阿维菌素B2a苯甲酸盐与氨基寡糖素的联合毒力
表5
Figure PCTCN2021134961-appb-000007
备注：A为甲氨基阿维菌素B2a苯甲酸盐，B为氨基寡糖素
表5结果表明，甲氨基阿维菌素B2a苯甲酸盐与氨基寡糖素的重量比在20:1-1:20区间内，共毒系数均大于120，表明二者增效明显。
药效实施例6
甲氨基阿维菌素B2a苯甲酸盐与橙花叔醇的室内毒力测定。
室内毒力试验方法同以上方法。因橙花叔醇并非农药成分，其本身对南方根节线虫无活性。因此使用增效比SR来评估二者的增效作用。试验结果如表6所示。
增效比SR＝药剂单用的LC50值/药剂和增效助剂联合的LC50值
表6甲氨基阿维菌素B2a苯甲酸盐与橙花叔醇的联合毒力
供试 配比 回归方程 相关系数 95％置信区间 LC50 增效比
药剂     r (mg/L) (mg/L) SR
A - Y＝4.1921+1.5629X 0.99 2.899-3.945 3.38 -
B - - - - >1000 -
A:B 60:1 Y＝3.9918+1.7427X 0.97 3.279-4.387 3.79 0.89
A:B 30:1 Y＝4.0508+1.8743X 0.967 2.825-3.646 3.21 1.05
A:B 20:1 Y＝4.0031+2.1339X 0.974 2.617-3.285 2.93 1.15
A:B 10:1 Y＝4.7835+1.6562X 0.977 1.177-1.551 1.35 2.50
A:B 5:1 Y＝4.8677+2.3261X 0.955 1.024-1.269 1.14 2.96
A:B 2:1 Y＝5.2647+2.1380X 0.979 0.66-0.856 0.75 4.51
A:B 1:1 Y＝5.2183+2.7455X 0.961 0.753-0.921 0.83 4.07
A:B 1:2 Y＝5.2720+1.8069X 0.944 0.607-0.824 0.71 4.76
A:B 1:5 Y＝5.0501+1.5283X 0.972 0.796-1.08 0.93 3.63
A:B 1:10 Y＝5.2691+2.2153X 0.988 0.667-0.857 0.76 4.45
A:B 1:20 Y＝4.6045+1.4540X 0.98 1.578-2.218 1.87 1.81
A:B 1:30 Y＝4.1148+1.3244X 0.99 3.808-5.702 4.66 0.73
A:B 1:60 Y＝3.2683+1.7149X 0.989 8.961-11.671 10.23 0.33
备注：A为甲氨基阿维菌素B2a苯甲酸盐，B为橙花叔醇；表中混剂的LC50指A与B的总质量浓度
由表6可知，橙花叔醇本身对南方根节线虫几乎没有杀虫效果，但是橙花叔醇能显著增强甲氨基阿维菌素B2a苯甲酸盐对南方根节线虫的毒力。当二者重量比为30:1-1:20区间内，增效比SR均大于1；而当二者重量比为2:1-1:10区间内，增效比SR甚至超过3，其中二者重量比为1:2时，增效比SR达到最大值4.76。
药效实施例7
甲氨基阿维菌素B2a苯甲酸盐与橙花叔醇的对韭蛆的室内毒力测定。
采用胃毒触杀法，以韭蛆3龄幼虫为为靶标对象，以甲氨基阿维菌素B2a苯甲酸盐与橙花叔醇为供试药剂，将药剂配置成不同浓度的药液。将干净滤纸 平铺在直径为8cm，底下铺有琼脂的培养皿内，在滤纸上滴加1mL配好的药液，将韭菜假茎部分剪成约2cm的小段，分别放于不同剂量的药液中浸泡30s，取出后用吸水纸吸去多余药液，放于滴加相同剂量药液的滤纸上，每培养皿3段随后用毛笔挑大小一致的3龄韭蛆幼虫放于培养皿内，每皿40头，3次重复，同时设清水为空白对照。48h后观察韭蛆存活数量；通过毒力回归方程v＝a+bx计算，并进行卡方检验。以机值分析法求出供试药剂的致死中浓LC 50及其95％置信限。使用增效比SR来评估二者的增效作用。试验结果如表7所示。
表7甲氨基阿维菌素B2a苯甲酸盐与橙花叔醇对韭蛆的联合毒力
Figure PCTCN2021134961-appb-000008
备注：A为甲氨基阿维菌素B2a苯甲酸盐，B为橙花叔醇；表中混剂的LC50指A与B的总质量浓度
由表7可知，橙花叔醇本身对韭蛆几乎没有杀虫效果，但是橙花叔醇能显著增强甲氨基阿维菌素B2a苯甲酸盐对韭蛆的毒力。当二者重量比为30:1-1:20区间内，增效比SR均大于1；而当二者重量比为2:1-1:10区间内，增效比SR甚至超过2，其中二者重量比为1:2时，增效比SR达到最大值2.75。
田间药效试验
药效实施例8甲氨基阿维菌素B2a苯甲酸盐与橙花叔醇混配制剂对番茄根节线虫的田间防治效果
试验于河北保定市定州番茄种植棚，土壤为壤土，土壤墒情良好，肥力中等，根结线虫危害严重。试验共设9个处理(处理区线虫危害基本均一，生态环境相同)，以清水做对照，每个处理重复4次，各处理随机摆列。每小区面积约15m 2，每小区定植40棵长势一般的番茄，定植时间为2020年8月20日。采用灌根或施撒方式进行试药。灌根处理在移植当天进行灌根施药，将药剂用水稀释，每株苗400ml稀释液处理；撒施处理在移植前进行，按15kg/亩拌土量将颗粒剂和细土搅匀制成毒土，折算成小区用量后，均匀撒施在小区内，并用钉耙混土，药剂入土深度15cm左右。撒好毒土后再进行番茄苗移栽定植。
在番茄移栽后2个月，每小区随机5点取样，每点取3株，共计15株，按照以下根结线虫分级标准进行番茄受害程度的评价，计算病情指数和防治效果。
调查方法按农药田间药效试验准则进行。
0级：无可见根瘤或卵块；
1级：根瘤总长度占总根长度的1％-24％；
2级：根瘤总长度占总根长度的25％-49％；
3级：根瘤总长度占总根长度的50％-74％；
4级：根瘤总长度占总根长度的75％-100％；
病情指数＝∑(各级病根数×相对级数值)/(调查总株数×4)×100；
防治效果(％)＝(1-处理病情指数/对照病情指数)×100。
表8田间防治番茄根节线虫试验结果
药剂 配比 有效用量g/hm 2 病情指数 防效/％
实施例1 2:1 400 9.2 87.67
实施例2 1:2 400 15.1 79.76
实施例3 1:4 400 13.4 82.04
实施例4 1:6 400 10.8 85.52
实施例5 1：8 400 12.6 83.11
实施例6 1：10 400 11.5 84.58
对比例1 - 400 26.7 64.21
对比例2 - 400 68.7 7.91
CK - - 74.6 -
备注：有效用量指甲氨基阿维菌素B2a苯甲酸盐与橙花叔醇总量
表8结果表明，橙花叔醇(对比例2)几乎对番茄根节线虫几乎无防效，甲氨基阿维菌素B2a苯甲酸盐(对比例1)防效为64.21％。而实施例1-6防效在79.76-87.67％之间，差异显著。表明橙花叔醇显著增强了甲氨基阿维菌素B2a苯甲酸盐对番茄根节线虫的防效。
药效实施例9甲氨基阿维菌素B2a苯甲酸盐与橙花叔醇混配制剂对黄瓜根节线虫的田间防治效果
试验于河南省信阳市新县黄瓜生产基地，根结线虫危害严重。试验地排灌方便土壤肥力中等，黄瓜品种为绿盈06-8。大棚遮阴育苗，10d苗龄后，在陇上定植，行距0.45m株距0.28m。每小区面积约15m 2，每小区定植60棵长势一般的黄瓜，定植时间为2020年7月30日。
试验共设9个处理(处理区线虫危害基本均一，生态环境相同)，以清水做对照，每个处理重复4次，各处理随机摆列。调查时间在最后一次黄瓜采摘后进行(80d)。每小区随机5点取样，每点取3株，共计15株，按照根结线虫分级标准进行黄瓜受害程度的评价，计算病情指数和防治效果。具体试验方法及调查计算方法同药效实施例8。
表9田间防治黄瓜根节线虫试验结果
药剂 配比 有效用量 病情指数 防效/％
    g/hm 2    
实施例1 2:1 450 17.2 78.82
实施例2 1:2 450 19.6 75.86
实施例3 1:4 450 15.4 81.03
实施例4 1:6 450 10.4 87.19
实施例5 1：8 450 12.9 84.11
实施例6 1：10 450 13.7 83.13
对比例1 - 450 35.6 56.16
对比例2 - 450 77.6 4.43
CK - - 81.2 -
备注：有效用量为甲氨基阿维菌素B2a苯甲酸盐与橙花叔醇总量
表9结果表明，橙花叔醇(对比例2)几乎对黄瓜根节线虫几乎无防效，甲氨基阿维菌素B2a苯甲酸盐(对比例1)防效为56.16％。而实施例1-6防效在75.86-87.19％之间，差异显著。表明橙花叔醇显著增强了甲氨基阿维菌素B2a苯甲酸盐对黄瓜根节线虫的防效。
药效实施例10甲氨基阿维菌素B2a苯甲酸盐与橙花叔醇混配制剂对韭蛆的田间防治效果
试验于河北省石家庄市藁城区童家庄村韭菜种植地，该地块常年种植韭菜，韭菜品种为平韭2号，韭蛆危害严重。试验地排灌方便土壤肥力中等，每小区面积约30m 2，试验共设9个处理(处理区韭蛆危害基本均一，生态环境相同)，以清水做对照，每个处理重复4次，各处理随机摆列。施药时间为2020年9月12日，施药方式为定点喷淋，喷雾器为WS-18D背负式电动喷雾器。将药剂用15L水稀释后倒入喷雾器药桶中，用喷头对准韭菜根茬逐一喷淋，每穴喷25mL。定点喷淋结束后，立即用大水浇灌试验小区，水深4-5cm。
施药前调查基数，施药后14、24d调查2次，调查受害株数及存活口数情 况。受害株数调查以小区中心2行各10墩，统计健株数与受害株数，存活口数调查在小区中心区刨出5墩韭菜，统计鳞茎内外活蛆数。分别以下式计算防治效果及保株效果：
防治效果(％)＝(对照区虫口数-处理区虫口数)/对照区虫口数*100
保株效果(％)＝(对照区药后受害株率-处理区药后受害贮率)/空白对照区药后受害株率*100
试验结果如下表所式。
表10田间防治韭蛆试验结果
Figure PCTCN2021134961-appb-000009
备注：有效用量为甲氨基阿维菌素B2a苯甲酸盐与橙花叔醇总量
表10结果表明，橙花叔醇(对比例2)对韭蛆几乎无防效，甲氨基阿维菌素B2a苯甲酸盐(对比例1)24d防治效果为69.2％，14d及24d保株效果分别为43.6％和61.3％。而实施例1-5,7的24d防治效果在87.2-98.6％之间，14d及24d保株效果分别在61.2％-75.3、82.7-92.5％之间，与单剂相比差异显著。表明橙花叔醇显著增强了甲氨基阿维菌素B2a苯甲酸盐对韭蛆的防效。
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发 明的精神和原则之内所作的任何修改、等同替换或改进等，均应包含在本发明的保护范围之内。

Claims (7)

  1. 一种含有甲氨基阿维菌素B2a苯甲酸盐的杀虫组合物，其特征在于：包括组分A和组分B，其中组分A为甲氨基阿维菌素B2a苯甲酸盐，组分B选自氟烯线砜、氟唑菌酰羟胺、三氟咪啶酰胺、三氟杀线酯、氨基寡糖素、橙花叔醇中的一种。
  2. 根据权利要求1所述的一种含有甲氨基阿维菌素B2a苯甲酸盐的杀虫组合物，其特征在于：组分A与组分B的重量比为1:60-60:1。
  3. 根据权利要求2所述的一种含有甲氨基阿维菌素B2a苯甲酸盐的杀虫组合物，其特征在于：
    甲氨基阿维菌素B2a苯甲酸盐与氟烯线砜的重量比为30:1-1:30；
    甲氨基阿维菌素B2a苯甲酸盐与氟唑菌酰羟胺的重量比为30:1-1:30；
    甲氨基阿维菌素B2a苯甲酸盐与三氟咪啶酰胺的重量比为60:1-1:20；
    甲氨基阿维菌素B2a苯甲酸盐与三氟杀线酯的重量比为20:1-1:20；
    甲氨基阿维菌素B2a苯甲酸盐与氨基寡糖素的重量比为20:1-1:20；
    甲氨基阿维菌素B2a苯甲酸盐与橙花叔醇的重量比为30:1-1:20。
  4. 根据权利要求3所述的一种含有甲氨基阿维菌素B2a苯甲酸盐的杀虫组合物，其特征在于：甲氨基阿维菌素B2a苯甲酸盐与橙花叔醇的重量比为2:1-1:10。
  5. 根据权利要求1-4任一项所述的一种含有甲氨基阿维菌素B2a苯甲酸盐的杀虫组合物，其特征在于：所述杀虫组合物的剂型是微乳剂、乳油、水乳剂、悬浮乳剂、油悬浮剂、颗粒剂中的一种。
  6. 根据权利要求1-4任一项所述的一种含有甲氨基阿维菌素B2a苯甲酸盐的杀虫组合物，其特征在于：所述杀虫组合物的施用方式为灌根、喷雾、撒施、沟施、穴施或拌种。
  7. 根据权利要求1-4任一项所述的一种含有甲氨基阿维菌素B2a苯甲酸盐的杀虫组合物，其特征在于：所述杀虫组合物用于防治植物线虫和防治地下害 虫韭蛆。
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