WO2023081842A3 - Voies de biosynthèse alternatives pour la production de psilocybine et intermédiaires ou produits secondaires - Google Patents

Voies de biosynthèse alternatives pour la production de psilocybine et intermédiaires ou produits secondaires Download PDF

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WO2023081842A3
WO2023081842A3 PCT/US2022/079329 US2022079329W WO2023081842A3 WO 2023081842 A3 WO2023081842 A3 WO 2023081842A3 US 2022079329 W US2022079329 W US 2022079329W WO 2023081842 A3 WO2023081842 A3 WO 2023081842A3
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psilocybin
production
intermediates
side products
streptomyces
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PCT/US2022/079329
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English (en)
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WO2023081842A2 (fr
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John Andrew Jones
Fiona KANIS
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Miami University
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Publication of WO2023081842A3 publication Critical patent/WO2023081842A3/fr

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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
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    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01028—Aromatic-L-amino-acid decarboxylase (4.1.1.28), i.e. tryptophane-decarboxylase
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Abstract

L'invention concerne des méthodes, des cellules hôtes procaryotes, des vecteurs d'expression et des kits pour la production de psilocybine ou d'un intermédiaire ou d'un produit secondaire de celle-ci. Selon certains modes de réalisation, la cellule hôte procaryote est choisie dans le groupe constitué par Escherichia coli, Corynebacterium glutamicum, Vibrio natriegens, Bacillus subtilis, Bacillus megaterium, Escherichia coli Nissle 1917, Clostridium acetobutlyicum, Streptomyces coelicolor, Lactococcus lactis, Pseudomonas putida, Streptomyces clavuligerus, et Streptomyces venezuelae.
PCT/US2022/079329 2021-11-05 2022-11-04 Voies de biosynthèse alternatives pour la production de psilocybine et intermédiaires ou produits secondaires WO2023081842A2 (fr)

Applications Claiming Priority (2)

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US202163263618P 2021-11-05 2021-11-05
US63/263,618 2021-11-05

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WO2023081842A2 WO2023081842A2 (fr) 2023-05-11
WO2023081842A3 true WO2023081842A3 (fr) 2023-06-15

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230202978A1 (en) 2022-03-04 2023-06-29 Reset Pharmaceuticals, Inc. Co-crystal or salt

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021086513A1 (fr) * 2019-10-28 2021-05-06 Miami University Procédés de production de psilocybine et intermédiaires ou produits secondaires

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021086513A1 (fr) * 2019-10-28 2021-05-06 Miami University Procédés de production de psilocybine et intermédiaires ou produits secondaires

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FELIX BLEI; JANIS FRICKE; JONAS WICK; JASON C. SLOT; DIRK HOFFMEISTER: "Iterative l‐Tryptophan Methylation in Psilocybe Evolved by Subdomain Duplication", CHEMBIOCHEM, vol. 19, no. 20, 2 October 2018 (2018-10-02), Hoboken, USA, pages 2160 - 2166, XP072200389, ISSN: 1439-4227, DOI: 10.1002/cbic.201800336 *

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