WO2023075165A1 - Composition antimicrobienne comprenant un composé antiseptique et de la reutérine, et son utilisation - Google Patents

Composition antimicrobienne comprenant un composé antiseptique et de la reutérine, et son utilisation Download PDF

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WO2023075165A1
WO2023075165A1 PCT/KR2022/014266 KR2022014266W WO2023075165A1 WO 2023075165 A1 WO2023075165 A1 WO 2023075165A1 KR 2022014266 W KR2022014266 W KR 2022014266W WO 2023075165 A1 WO2023075165 A1 WO 2023075165A1
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luterin
weight
preservative
cosmetic composition
composition
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PCT/KR2022/014266
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English (en)
Korean (ko)
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이경민
이우정
이미영
이길용
박재형
이주훈
조희원
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코오롱인더스트리(주)
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Priority claimed from KR1020210143977A external-priority patent/KR102394120B1/ko
Priority claimed from KR1020220034592A external-priority patent/KR20230137014A/ko
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Publication of WO2023075165A1 publication Critical patent/WO2023075165A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to an antibacterial composition, a cosmetic composition, and a preservative for cosmetic preservation containing a preservative compound and luterin for inhibiting the activity of microorganisms or killing microorganisms.
  • Microorganisms decompose organic matter or organic compounds to produce substances useful to humans, but also produce substances harmful to humans with odors and chemically and biologically degenerate them.
  • contamination by microorganisms during the manufacturing process and microbial contamination by skin contact such as fingers during use cannot be avoided.
  • the use of preservatives is unavoidable.
  • Preservatives are formulated into cosmetics to suppress the proliferation of microorganisms that contaminate cosmetics from the outside, and to prevent product changes by killing microorganisms over time.
  • Preservatives that are mainly used are synthetic preservatives containing chemical substances, such as paraoxybenzoic acid esters (parabens), imidazolidinyl urea, phenoxyethanol, etc., and diols with two hydroxyl groups.
  • a based compound or surfactant may also be used as a preservative.
  • luterin a natural antibacterial substance, has been reported as a substance showing a wide spectrum of antimicrobial activity.
  • the antibacterial activity is low in the presence of amino acids, it is difficult to apply to products containing amino acids (Eunmi Yeom et al., Journal of Korean Food Science 2004. 36(1): 111-115).
  • Patent Document 1 Republic of Korea Patent Registration No. 10-2013565
  • Patent Document 2 Republic of Korea Patent Registration No. 10-2136623
  • Patent Document 3 Republic of Korea Patent Registration No. 10-1472518
  • An object of the present invention is to provide an antibacterial composition for inhibiting the activity of microorganisms such as bacteria and fungi or killing microorganisms, a cosmetic composition, and a preservative for cosmetic preservation.
  • One aspect of the present invention provides an antimicrobial composition
  • an antimicrobial composition comprising an antiseptic compound and luterin as active ingredients.
  • preservative compound used in the present invention refers to a compound added to prevent chemical or biological deterioration of a substance, and may include a compound used as a preservative or disinfectant.
  • a preservative or disinfectant In view of the chemical toxicity of preservative compounds, cosmetics, foods, and medicines must use safe substances that are not toxic to the human body, so in the present invention, any preservative compound that is chemically safe and harmless can be used without limitation.
  • preservative compound examples include parabens, paraffins, alkanediols, phenoxyethanol, imidazolidinyl urea, diazolidinyl urea ), isopropyl alcohol, chlorophene, formic acid, piroctone olamine, hexetidine, hexamidine, isothiazolinone ), hydroxyacetophenone, glyceryl caprylate, ethylhexylglycerin, sodium benzoate, etc., but are not limited thereto.
  • the preservative compound may be at least one selected from the group consisting of alkane diol, hydroxyacetophenone, glyceryl caprylate, ethylhexyl glycerin and sodium benzoate.
  • the alkane diol refers to a compound in which two hydroxyl groups (-0H) are connected to a saturated hydrocarbon (alkane) that forms a chain with a single bond between carbons. It is classified as 1,4-, 2,3-, 2,4-, 2,5-, etc.
  • alkanediols are mainly used as moisturizing ingredients in cosmetics and pharmaceuticals, but since they contain a hydrophilic hydroxyl group and a hydrophobic carbon chain, they are amphiphilic and can easily penetrate cell membranes of microorganisms, thereby exhibiting excellent antibacterial activity.
  • the alkanediol preferably has 3 to 12 carbon atoms.
  • the alkane diol may be an alkane diol having 3 to 12 carbon atoms.
  • the alkanediol includes propanediol, butanediol, pentanediol, hexanediol, octanediol, decanediol and dodecanediol. It may be one or more selected from the group consisting of.
  • the alkanediol may be at least one selected from the group consisting of propanediol, butanediol, pentanediol, hexanediol, and octanediol.
  • 1,2-alkanediol, 1,3-alkanediol, or 2,3-alkanediol is preferable to enhance antibacterial activity.
  • the hydroxyacetophenone is a plant-derived ingredient used as a natural antioxidant in cosmetics, and has a weaker preservative power than parabens, but is more skin-friendly and increases the preservative function when used with other preservatives including parabens.
  • These hydroxyacetophenones are classified into 2-, 3- and 4-hydroxyacetophenones according to the position of the hydroxy group (-OH), but there is no difference in preservative function.
  • the glyceryl caprylate is a plant-derived ingredient that serves as a kind of surfactant and is mainly used as an emulsifier in cosmetics, and has excellent antibacterial and antifungal effects, so it can be used as a substitute for preservatives.
  • the ethylhexylglycerin has a wetting property and is mainly used for the moisturizing effect of cosmetics, but also serves to increase the antibacterial power of common preservatives such as phenoxyethanol, isothiazolinone, and paraben, and is used to reduce the amount of such preservatives. It also has antibacterial activity that inhibits the growth of odor-causing anaerobic bacteria in the human body.
  • the sodium benzoate is a compound that is effective in inhibiting the growth of various microorganisms such as bacteria, yeast, and fungi. It is inexpensive, has excellent antibacterial effect, and is low in toxicity, and is mainly used as a food preservative. In cosmetics, it replaces parabens. It is one of the synthetic preservatives.
  • reuterin refers to 3-hydroxypropionaldehyde, a natural antimicrobial substance produced by Lactobacillus reuteri from glycerol.
  • the luterin has antibacterial activity against not only pathogenic bacteria but also yeast and mold, and thus has a very broad antibacterial spectrum (Doleyres et al., Appl Microbiol Biotechnol 2005, 68: 467-474).
  • the luterin may be isolated from Lactobacillus reuteri or a culture medium thereof.
  • the "culture medium” used in the present invention refers to nutrients necessary for the survival, development, or proliferation of Lactobacillus reuteri, and may also include enzymes and metabolites produced by the Lactobacillus reuteri and secreted to the outside.
  • a composition comprising such an antiseptic compound and luterin may exhibit antibacterial activity.
  • Antimicrobial as used in the present invention means the ability to reduce, prevent, inhibit or eliminate the growth or survival of microorganisms such as bacteria and fungi at a certain concentration
  • antimicrobial composition refers to substances exhibiting such antibacterial activity. means a composition comprising
  • the antimicrobial composition may have antibacterial activity against bacteria and fungi.
  • the antibacterial composition is Escherichia (Escherichia ) genus, Staphylococcus ( Staphylococcus ) genus, Pseudomonas ( Pseudomonas ) genus, Candida ( Candida ) and Aspergillus ( Aspergillus ) genus It may have antibacterial activity against one or more bacteria selected from the group consisting of.
  • the antibacterial composition contains a preservative compound and luterin, thereby exhibiting sufficient antibacterial activity even in a small amount compared to the amount of preservative compound or luterin used for antibacterial activity in the past, maintaining formulation stability of the product and extending shelf life. can do.
  • the antimicrobial composition may be one containing 0.01 to 50% by weight of an antiseptic compound based on the total weight.
  • the amount of the preservative compound is 0.01 to 50% by weight, 0.01 to 10% by weight, 0.01 to 5% by weight, 0.01 to 1% by weight, 0.05 to 50% by weight, 0.05 to 50% by weight based on the total weight of the antimicrobial composition.
  • to 10 wt% 0.05 to 5 wt%, 0.05 to 1 wt%, 0.1 to 50 wt%, 0.1 to 10 wt%, 0.1 to 5 wt%, 0.1 to 1 wt%, 0.5 to 50 wt%, 0.5 to 10 0.5 to 5 wt%, 0.5 to 1 wt%, 1 to 50 wt%, 1 to 10 wt%, 1 to 5 wt%, 5 to 50 wt%, or 10 to 50 wt%.
  • the amount of the preservative compound When the amount of the preservative compound is less than 0.01% by weight, antibacterial activity against bacteria and fungi is not shown, and a large amount of luterin is unavoidable to improve antibacterial activity, and when the amount of the preservative compound exceeds 50% by weight, the product This thinning may cause a problem with formulation stability and greatly increase skin irritation.
  • the antimicrobial composition may contain 0.05 to 50 mM of luterin.
  • the concentration of luterin in the antimicrobial composition is 0.05 to 50 mM, 0.05 to 10 mM, 0.05 to 5 mM, 0.1 to 50 mM, 0.1 to 10 mM, 0.1 to 5 mM, 0.5 to 50 mM, 0.5 to 10 mM, 0.5 to 5 mM, 1 to 50 mM, 1 to 10 mM, or 1 to 5 mM.
  • concentration of luterin is less than 0.05 mM, it may not exhibit antibacterial activity or may show limited antibacterial activity only in some microorganisms, and if the concentration of luterin exceeds 50 mM, formulation stability may be adversely affected.
  • luterin exhibits antibacterial activity against bacteria ( E. Coli , P. aeruginosa and S. aureus ) and fungi ( C. albicans and A. niger ) even when used alone, but is a preservative compound.
  • This antibacterial composition can be applied in any formulation such as liquid, oil, cream, paste, solid, etc., and can be used for products applied to the body, such as the body, skin, oral cavity, and hair.
  • the antibacterial composition according to the present invention may be utilized in various fields depending on the purpose or aspect of use, and may be embodied as, for example, a cosmetic composition or an additive thereof.
  • the additive is an additive for preventing deterioration, decay, discoloration, and chemical change of the product by microorganisms, and may be a preservative, a preservative, a bactericide, etc., based on the total weight of the cosmetic composition, 0.01 to 50% by weight, 0.5 to 25% by weight, 0.1 to 10% by weight, or 0.5 to 5% by weight may be included.
  • Antibacterial composition according to the present invention can be implemented as a cosmetic composition.
  • the cosmetic composition may contain an antibacterial compound and luterin as active ingredients.
  • the cosmetic composition may further include ingredients commonly used in cosmetic compositions, for example, antioxidants, stabilizers, solubilizers, vitamins, pigments, fragrances, and the like.
  • the cosmetic composition may be prepared without limitation in formulations commonly used in the art, for example, skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutrient lotion, massage cream, nutrient cream , Moisture Cream, Hand Cream, Essence, Nutrition Essence, Pack, Soap, shampoo, Cleansing Foam, Cleansing Lotion, Cleansing Cream, Body Lotion, Body Cleanser, Emulsion, Lipstick, Makeup Base, Foundation, Press Powder, Loose Powder, Eye Shadow It can be prepared in formulations such as
  • the cosmetic composition may include 0.01 to 50% by weight of an antiseptic compound based on the total weight.
  • the amount of the preservative compound is 0.01 to 50% by weight, 0.01 to 10% by weight, 0.01 to 5% by weight, 0.01 to 1% by weight, 0.05 to 50% by weight, 0.05 to 50% by weight based on the total weight of the cosmetic composition. 10 wt%, 0.05 to 5 wt%, 0.05 to 1 wt%, 0.1 to 50 wt%, 0.1 to 10 wt%, 0.1 to 5 wt%, 0.1 to 1 wt%, 0.5 to 50 wt%, 0.5 to 10 wt% %, 0.5 to 5%, 0.5 to 1%, 1 to 50%, 1 to 10%, 1 to 5%, 5 to 50%, or 10 to 50%.
  • the cosmetic composition may contain 0.05 to 50 mM of luterin.
  • the concentration of luterin in the cosmetic composition is 0.05 to 50 mM, 0.05 to 10 mM, 0.05 to 5 mM, 0.1 to 50 mM, 0.1 to 10 mM, 0.1 to 5 mM, 0.5 to 50 mM, 0.5 to 10 mM, 0.5 to 5 mM, 1 to 50 mM, 1 to 10 mM, or 1 to 5 mM.
  • the antibacterial composition according to the present invention can be implemented as a preservative for preserving cosmetics.
  • the preservative for preserving cosmetics may be a preservative for preserving cosmetics containing a preservative compound and luterin as active ingredients.
  • the preservative for preserving cosmetics is an additive used in manufacturing cosmetics to prevent spoilage, and particularly serves to prevent biological deterioration.
  • the preservative for preserving cosmetics may include 0.01 to 50% by weight of a preservative compound based on the total weight.
  • the amount of the preservative compound is 0.01 to 50% by weight, 0.01 to 10% by weight, 0.01 to 5% by weight, 0.01 to 1% by weight, 0.05 to 50% by weight, based on the total weight of the preservative for cosmetic preservation.
  • the preservative for preserving cosmetics may contain 0.05 to 50 mM of luterin.
  • the concentration of luterin is 0.05 to 50 mM, 0.05 to 10 mM, 0.05 to 5 mM, 0.1 to 50 mM, 0.1 to 10 mM, 0.1 to 5 mM, 0.5 to 50 mM, 0.5 to 10 mM in the preservative for cosmetic preservation. , 0.5 to 5 mM, 1 to 50 mM, 1 to 10 mM, or 1 to 5 mM.
  • the preservative for preserving cosmetics may further include components commonly used depending on the type and purpose of use of the product, and may further include, for example, acetic acid, sodium acetate-based, sorbic acid-based, benzoic acid-based, propionic acid-based, etc. .
  • the antibacterial composition according to the present invention can improve formulation stability by minimizing the amount of preservative compound and luterin by including a preservative compound and luterin, and can secure antimicrobial activity in the formulation even if the amount used is reduced compared to the use of a preservative compound or luterin alone. It can be used as a preservative compound or a cosmetic composition that compensates for the disadvantages of luterin, a preservative for cosmetic preservation, and the like.
  • FIG. 1 is a graph showing the change in viscosity of a cosmetic composition including an antibacterial composition according to an embodiment of the present invention.
  • Alkanediols of (1,2-HD) and 1,2-octanediol (1,2-OD) 4-hydroxyacetophenone (4-HA), glycerylcaprylate (GC), ethylhexylglycerin (EHG) ) and sodium benzoate (SB) were used.
  • Reuterin was obtained and used through microbial culture.
  • MRS medium (10 g/L Proteose Peptone NO.3, 10 g/L beef extract, 5 g/L yeast extract, 20 g /L dextrose, 1 g/L polysorbate 80, 2 g/L ammonium citrate, 5 g/L sodium acetate, 0.1 g/L magnesium sulfate, 0.05 g/L manganese sulfate, and After culturing in 2 g/L of dipotassium sulfate), the culture medium was centrifuged at 13,000 rpm for 5 minutes, and the cells were collected and washed twice in 50 mM sodium phosphate buffer (pH 7.5).
  • the washed cells were resuspended in a 200 mM glycerol solution, allowed to stand in an incubator at 30° C., and samples were taken at intervals of 1 hour. Reuterin at a concentration of 100 mM was obtained and used in subsequent examples.
  • Antibacterial evaluation was performed on the antibacterial composition containing alkanediol and luterin.
  • luterin alone or luterin and alkanediol were mixed at a weight ratio of 1: 1 and added to 0.5 to 4% by weight. At this time, in the medium The final luterin concentration was 0.5 to 4 mM. Thereafter, bacteria were inoculated to a concentration of 10 7 cfu/ml and cultured at 37°C for 1 day, or fungi were inoculated to a concentration of 10 5 cfu/ml and cultured at 30°C for 2 days to confirm the MIC value. The results are shown in Table 1 below.
  • the antibacterial composition contains 0.1 to 30 wt. weight of alkanediol (1,3-propanediol, 2,3-butanediol, 1,2-pentanediol, 1,2-hexanediol or 1,2-octanediol) in 0.85% NaCl buffer. % and/or 0.1 to 3 wt% (0.1 to 3 mM) of lutein. 10 5 cfu/mL of C. albicans or A. niger was inoculated in 10 mL of the antibacterial composition and cultured with shaking for 72 hours in a 30°C incubator.
  • the MBC (minimum bactericidal concentration) evaluation results for C. albicans and A. niger are shown in Tables 2 and 3, respectively.
  • Formulation stability was confirmed by preparing a cosmetic composition containing an alkanediol alone or an alkanediol and luterin. 1,2-HD was used as the alkanediol.
  • the raw materials and contents of the cosmetic composition are shown in Table 4 below, and were prepared in a lotion formulation.
  • Cosmetic Composition 1 Cosmetic Composition 2
  • Carbopol 981 0.2wt% 0.2wt% Glycerin 5.0wt% 5.0wt% Cetyl alcohol 0.5wt% 0.5wt% Stearyl alcohol 0.5wt% 0.5wt% MCTs 2.0wt% 2.0wt% LP 70 3.0wt% 3.0wt% Olivem 1000 1.5wt% 1.5wt% Triethanolamine 0.2wt% 0.2wt% 1,2-HD 3.0wt% 1.0wt% Reuterin 0 1.0 wt % (1 mM) Distilled water To 100wt% To 100wt% To 100wt% To 100wt% To 100wt% To 100wt% To 100wt% To 100wt% To 100wt% To 100wt% To 100wt% To 100wt% To 100wt%
  • Viscosity evaluation (unit: cps) was conducted by putting each cosmetic composition in a transparent container and operating a viscometer (LV pro VISCOMETER, BROOKFIELD) equipped with a No. 64 spindle at 25 ° C. at 50 rpm.
  • cosmetic composition 1 containing 1,2-HD alone showed a decrease in viscosity
  • cosmetic composition 2 containing 1,2-HD and luterin showed no change in viscosity. confirmed that
  • An antimicrobial composition containing hydroxyacetophenone, glyceryl caprylate, ethylhexyl glycerin or sodium benzoate, and luterin was subjected to antibacterial evaluation.
  • fungi Candida albicans ATCC 10231 and Aspergillus niger ATCC 16404 designated by the United States Pharmacopoeia were used.
  • C. albicans was subcultured twice in SDB medium, and A. niger spores obtained by plating on SDA medium were used in the experiment.
  • luterin alone or luterin and an antiseptic compound were added at respective concentrations to a 0.8% NaCl aqueous solution, and the final concentration of luterin was 0.5 to 1.5 mM. Thereafter, the fungus was inoculated to 10 5 cfu/ml, stored at 30° C. for 3 days, and then 100 uL was smeared on SDA medium. The smeared samples were incubated at 30° C. for 3 days to confirm whether or not colonies were formed. The results are shown in Table 5 below.
  • antifungal activity was observed when 0.1 to 0.2% by weight of hydroxyacetophenone, 0.1 to 0.2% by weight of glyceryl caprylate, 0.05 to 0.1% by weight of ethylhexylglycerin, or 0.3 to 0.4% by weight of sodium benzoate was used alone. However, it was confirmed that antifungal activity appeared as the concentration of luterin increased.
  • Escherichia coli ATCC 8739, Pseudomonas aeruginosa ATCC 9027, and Staphylococcus aureus ATCC 6538 designated by the United States Pharmacopoeia (USP) were used. Bacteria were subcultured twice in TSB medium and used in experiments.
  • luterin alone or luterin and an antiseptic compound were added at respective concentrations to a 0.8% NaCl aqueous solution, and the final concentration of luterin was 0.5 to 1.5 mM. Thereafter, the bacteria were inoculated to a concentration of 10 7 cfu/ml, stored at 37° C. for 3 days, and then 100 uL was smeared on a TSA medium. The smeared sample was incubated at 37 ° C. to confirm the presence or absence of colony formation. The results are shown in Table 6 below.
  • Each cosmetic composition was inoculated to 10 7 cfu/ml for bacteria and 10 5 cfu/ml for fungi, and then stored at 37°C and 30°C for 3 days, respectively. After mixing 100 uL of the sample with 900 uL of Letheen medium, it was smeared on TSA for bacteria and SDA for fungi, respectively. The smeared samples were incubated at 37 ° C and 30 ° C for 3 days, respectively, to confirm the presence or absence of colony formation. The results are shown in Table 9 below.
  • '4-2 In order to check whether the antibacterial activity in the cosmetic formulation is maintained, '4-2. It was confirmed whether the antibacterial activity was maintained by cumulatively inoculating each strain using the bacterial or fungal inoculated samples (cosmetic compositions 4 to 7 and 9 to 12) used in 'Evaluation of antibacterial activity in cosmetic formulations'.
  • bacteria three species, namely E. coli , P. aeruginosa and S. aureus were mixed and inoculated to 10 7 CFU/ml, and in the case of fungi, C. albicans and A. niger were mixed to 10 5 CFU/ml, respectively. Inoculated.

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Abstract

La présente invention se rapporte à une composition antimicrobienne, à une composition cosmétique et à un conservateur servant à la conservation de produits cosmétiques, la composition antimicrobienne comprenant un composé antiseptique et de la reutérine afin d'inhiber l'activité microbienne ou de tuer des micro-organismes. La composition antimicrobienne comprend le composé antiseptique et de la reutérine et peut ainsi être utilisée en tant que composition cosmétique, conservateur servant à la conservation de produits cosmétiques, etc. la quantité à utiliser du composé antiseptique étant ainsi réduite au minimum, et, par conséquent, la stabilité de formulation pouvant être améliorée, et la quantité à utiliser peut être réduite par rapport à l'utilisation de la reutérine seule, et ainsi l'activité antimicrobienne dans la formulation peut être assurée, et ainsi les inconvénients du composé antiseptique ou de la reutérine sont compensés.
PCT/KR2022/014266 2021-10-26 2022-09-23 Composition antimicrobienne comprenant un composé antiseptique et de la reutérine, et son utilisation WO2023075165A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2021-0143977 2021-10-26
KR1020210143977A KR102394120B1 (ko) 2021-10-26 2021-10-26 알칸디올 및 루테린을 포함하는 항균용 조성물 및 이의 용도
KR10-2022-0034592 2022-03-21
KR1020220034592A KR20230137014A (ko) 2022-03-21 2022-03-21 방부 화합물 및 루테린을 포함하는 항균용 조성물 및 이의 용도

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08256746A (ja) * 1995-03-20 1996-10-08 Asama Kasei Kk 食品用保存剤
JPH08289769A (ja) * 1995-04-20 1996-11-05 Asama Kasei Kk 食品用保存剤
US20070264401A1 (en) * 2006-05-12 2007-11-15 Taormina Peter J Beverage preservatives
US20160271189A1 (en) * 2015-03-18 2016-09-22 Whole Biome, Inc. Methods and compositions relating to microbial treatment and diagnosis of skin disorders
US20190343894A1 (en) * 2017-01-05 2019-11-14 Georgia State University Research Foundation, Inc. Antimicrobial compositions and methods of using same
KR102394120B1 (ko) * 2021-10-26 2022-05-04 코오롱인더스트리(주) 알칸디올 및 루테린을 포함하는 항균용 조성물 및 이의 용도

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08256746A (ja) * 1995-03-20 1996-10-08 Asama Kasei Kk 食品用保存剤
JPH08289769A (ja) * 1995-04-20 1996-11-05 Asama Kasei Kk 食品用保存剤
US20070264401A1 (en) * 2006-05-12 2007-11-15 Taormina Peter J Beverage preservatives
US20160271189A1 (en) * 2015-03-18 2016-09-22 Whole Biome, Inc. Methods and compositions relating to microbial treatment and diagnosis of skin disorders
US20190343894A1 (en) * 2017-01-05 2019-11-14 Georgia State University Research Foundation, Inc. Antimicrobial compositions and methods of using same
KR102394120B1 (ko) * 2021-10-26 2022-05-04 코오롱인더스트리(주) 알칸디올 및 루테린을 포함하는 항균용 조성물 및 이의 용도

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