WO2023074594A1 - 信号処理装置、認知機能改善システム、信号処理方法、及びプログラム - Google Patents

信号処理装置、認知機能改善システム、信号処理方法、及びプログラム Download PDF

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WO2023074594A1
WO2023074594A1 PCT/JP2022/039422 JP2022039422W WO2023074594A1 WO 2023074594 A1 WO2023074594 A1 WO 2023074594A1 JP 2022039422 W JP2022039422 W JP 2022039422W WO 2023074594 A1 WO2023074594 A1 WO 2023074594A1
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Prior art keywords
acoustic signal
signal processing
output
processing device
signal
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PCT/JP2022/039422
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English (en)
French (fr)
Japanese (ja)
Inventor
芳樹 長谷
和希 高澤
公一 小川
佳主馬 前田
達也 柳川
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Shionogi and Co Ltd
Pixie Dust Technologies Inc
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Shionogi and Co Ltd
Pixie Dust Technologies Inc
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Priority to EP22886921.0A priority Critical patent/EP4425490A4/en
Priority to JP2022574497A priority patent/JP7410477B2/ja
Priority to CN202280071534.6A priority patent/CN118160035A/zh
Priority to US18/171,844 priority patent/US20230190174A1/en
Publication of WO2023074594A1 publication Critical patent/WO2023074594A1/ja
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Definitions

  • the present disclosure relates to a signal processing device, a cognitive function improvement system, a signal processing method, and a program.
  • Gamma waves refer to those whose frequency is included in the gamma band (25 to 140 Hz) among nerve vibrations obtained by capturing periodic nerve activity in the cortex of the brain by electrophysiological techniques such as electroencephalograms and magnetoencephalography.
  • U.S. Patent No. 5,300,000 discloses adjusting the volume by increasing or decreasing the amplitude of sound waves or soundtracks to create rhythmic stimulation corresponding to stimulation frequencies that induce brain wave entrainment.
  • Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improvements Cognition Cell 2019 Apr 4;177(2):256-271.e22. doi: 10.1016/j.cell.2019.02.014.
  • the purpose of the present disclosure is to change the amplitude of the acoustic signal while suppressing discomfort given to the listener.
  • a signal processing device includes means for receiving an input acoustic signal, and amplitude-modulating the received input acoustic signal to have an amplitude change corresponding to a gamma wave frequency, and an amplitude waveform envelope means for generating an output acoustic signal whose rise and fall are asymmetric; and means for outputting the generated output acoustic signal.
  • FIG. 1 is a block diagram showing the configuration of an acoustic system of this embodiment
  • FIG. 1 is a block diagram showing the configuration of a signal processing device according to an embodiment
  • FIG. 1 is an explanatory diagram of one aspect of the present embodiment
  • FIG. 4 is a diagram showing a first example of an amplitude waveform of an output acoustic signal
  • FIG. 10 is a diagram showing a second example of an amplitude waveform of an output acoustic signal
  • FIG. 10 is a diagram showing a third example of an amplitude waveform of an output acoustic signal; It is a figure which shows the result of experiment. It is a figure which shows the whole acoustic signal processing flow by the signal processing apparatus of this embodiment.
  • FIG. 10 is a diagram showing experimental results of electroencephalogram induction by sound stimulation.
  • FIG. 4 is a diagram showing the correlation between results of psychological experiments and electroencephalogram measurements;
  • FIG. 1 is a block diagram showing the configuration of the acoustic system of this embodiment.
  • the sound system 1 includes a signal processing device 10, a sound output device 30, and a sound source device 50.
  • the signal processing device 10 and the sound source device 50 are connected to each other via a predetermined interface capable of transmitting acoustic signals.
  • the interface is, for example, SPDIF (Sony Philips Digital Interface), HDMI (High-Definition Multimedia Interface), pin connector (RCA pin), or an audio interface for headphones.
  • the interface may be a wireless interface using Bluetooth (registered trademark) or the like.
  • the signal processing device 10 and the sound output device 30 are similarly connected to each other via a predetermined interface.
  • the acoustic signal in this embodiment includes either or both of an analog signal and a digital signal.
  • the signal processing device 10 performs acoustic signal processing on the input acoustic signal acquired from the sound source device 50 .
  • Acoustic signal processing by the signal processing device 10 includes at least modulation processing of an acoustic signal (details will be described later).
  • the acoustic signal processing by the signal processing device 10 may include conversion processing (for example, separation, extraction, or synthesis) of acoustic signals.
  • the acoustic signal processing by the signal processing device 10 may further include acoustic signal amplification processing similar to that of an AV amplifier, for example.
  • the signal processing device 10 sends the output acoustic signal generated by the acoustic signal processing to the acoustic output device 30 .
  • the signal processing device 10 is an example of an information processing device.
  • the sound output device 30 generates sound according to the output sound signal acquired from the signal processing device 10 .
  • the sound output device 30 is, for example, a loudspeaker (which may include powered speakers), headphones, or earphones.
  • the sound output device 30 can also be configured as one device together with the signal processing device 10 .
  • the signal processing device 10 and the sound output device 30 can be mounted on a TV, radio, music player, AV amplifier, speaker, headphone, earphone, smart phone, or PC.
  • the signal processing device 10 and the sound output device 30 constitute a cognitive function improvement system.
  • the sound source device 50 sends out the input acoustic signal to the signal processing device 10 .
  • the sound source device 50 is, for example, a TV, a radio, a music player, a smart phone, a PC, an electronic musical instrument, a telephone, a game machine, a game machine, or a device that conveys an acoustic signal by broadcasting or information communication.
  • FIG. 2 is a block diagram showing the configuration of the signal processing device of this embodiment.
  • the signal processing device 10 includes a storage device 11, a processor 12, an input/output interface 13, and a communication interface 14.
  • the signal processing device 10 is connected to the display 21 .
  • the storage device 11 is configured to store programs and data.
  • the storage device 11 is, for example, a combination of ROM (Read Only Memory), RAM (Random Access Memory), and storage (eg, flash memory or hard disk).
  • the program and data may be provided via a network, or may be provided by being recorded on a computer-readable recording medium.
  • Programs include, for example, the following programs. ⁇ OS (Operating System) program ⁇ Application program that executes information processing
  • the data includes, for example, the following data. ⁇ Databases referenced in information processing ⁇ Data obtained by executing information processing (that is, execution results of information processing)
  • the processor 12 is a computer that implements the functions of the signal processing device 10 by reading and executing programs stored in the storage device 11 . At least part of the functions of the signal processing device 10 may be realized by one or more dedicated circuits.
  • Processor 12 is, for example, at least one of the following: ⁇ CPU (Central Processing Unit) ⁇ GPU (Graphic Processing Unit) ⁇ ASIC (Application Specific Integrated Circuit) ⁇ FPGA (Field Programmable Array) ⁇ DSP (digital signal processor)
  • the input/output interface 13 is configured to acquire user instructions from input devices connected to the signal processing apparatus 10 and to output information to output devices connected to the signal processing apparatus 10 .
  • the input device is, for example, the sound source device 50, physical buttons, keyboard, pointing device, touch panel, or a combination thereof.
  • the output device is, for example, display 21, sound output device 30, or a combination thereof.
  • the input/output interface 13 may include signal processing hardware such as A/D converters, D/A converters, amplifiers, mixers, filters, and the like.
  • the communication interface 14 is configured to control communication between the signal processing device 10 and an external device (for example, the sound output device 30 or the sound source device 50).
  • an external device for example, the sound output device 30 or the sound source device 50.
  • the display 21 is configured to display images (still images or moving images).
  • the display 21 is, for example, a liquid crystal display or an organic EL display.
  • FIG. 3 is an explanatory diagram of one aspect of the present embodiment.
  • the signal processing device 10 modulates an input acoustic signal to generate an output acoustic signal.
  • Modulation is amplitude modulation using a modulation function having a frequency corresponding to gamma waves (for example, frequencies between 35 Hz and 45 Hz).
  • a modulation function having a frequency corresponding to gamma waves (for example, frequencies between 35 Hz and 45 Hz).
  • an amplitude change (volume intensity) corresponding to the frequency is added to the acoustic signal.
  • the amplitude waveforms of the output acoustic signals are different. Examples of amplitude waveforms will be described later.
  • the signal processing device 10 sends the output acoustic signal to the acoustic output device 30 .
  • the sound output device 30 generates an output sound according to the output sound signal.
  • a user US1 listens to the output sound emitted from the sound output device 30.
  • the user US1 is, for example, a patient with dementia, a pre-dementia group, or a healthy person who expects prevention of dementia.
  • the output acoustic signal is based on an output acoustic signal that has been modulated using a modulation function with a periodicity between 35 Hz and 45 Hz. Therefore, when the user US1 listens to the sound emitted from the sound output device 30, gamma waves are induced in the brain of the user US1. As a result, an effect of improving the cognitive function of the user US1 (for example, treating or preventing dementia) can be expected.
  • FIG. 4 is a diagram showing a first example of the amplitude waveform of the output acoustic signal.
  • A(t) be the modulation function used to modulate the input acoustic signal
  • X(t) be the function representing the waveform of the input acoustic signal before modulation
  • Y be the function representing the waveform of the output acoustic signal after modulation.
  • the modulation function has a reverse sawtooth waveform at 40 Hz.
  • the input acoustic signal is an acoustic signal representing a homogeneous sound with a constant frequency higher than 40 Hz and a constant sound pressure.
  • the envelope of the amplitude waveform of the output acoustic signal has a shape along the reverse sawtooth wave.
  • the amplitude waveform of the output acoustic signal has an amplitude change corresponding to the frequency of the gamma wave, and the rising portion C and the falling portion B of the envelope A of the amplitude waveform are It is asymmetrical (that is, the rising time length and the falling time length are different).
  • the rise of the envelope A of the amplitude waveform of the output acoustic signal in the first example is steeper than the fall. In other words, the time required for rising is shorter than the time required for falling.
  • the amplitude value of the envelope A sharply rises to the maximum value of amplitude and then gradually falls with the lapse of time. That is, the envelope A has a reverse sawtooth wave shape.
  • FIG. 5 is a diagram showing a second example of the amplitude waveform of the output acoustic signal.
  • the modulation function has a sawtooth waveform at 40 Hz.
  • the input acoustic signal is an acoustic signal representing a homogeneous sound with a constant frequency higher than 40 Hz and a constant sound pressure.
  • the envelope of the amplitude waveform of the output acoustic signal has a shape along the sawtooth wave. Specifically, as shown in FIG. 5, the fall of the envelope A of the amplitude waveform of the output acoustic signal in the second example is steeper than the rise. In other words, the time required for falling is shorter than the time required for rising. The amplitude value of the envelope A gradually rises over time to the maximum value of the amplitude, and then sharply falls. That is, the envelope A has a sawtooth waveform.
  • FIG. 6 is a diagram showing a third example of the amplitude waveform of the output acoustic signal.
  • the modulation function has a sinusoidal waveform at 40 Hz.
  • the input acoustic signal is an acoustic signal representing a homogeneous sound with a constant frequency higher than 40 Hz and a constant sound pressure.
  • the envelope of the amplitude waveform of the output acoustic signal has a shape along the sine wave. Specifically, as shown in FIG.
  • both the rise and fall of the envelope A of the amplitude waveform of the output acoustic signal in the third example are smooth. That is, the envelope A is sinusoidal.
  • the modulation function has a periodicity of 40 Hz, but the frequency of the modulation function is not limited to this, and may be, for example, a frequency of 35 Hz or more and 45 Hz or less.
  • the absolute value of the amplitude value of the envelope A is periodically set to 0, but this is not limiting, and the minimum absolute value of the amplitude value of the envelope A is A modulation function that results in a value greater than 0 (eg, half or quarter the maximum absolute value) may be used.
  • the sound pressure and frequency of the input acoustic signal are constant in the examples shown in FIGS. 4 to 6, the sound pressure and frequency of the input acoustic signal may vary.
  • the input audio signal may be a signal representing music, speech, environmental sounds, electronic sounds, or noise.
  • the envelope of the amplitude waveform of the output acoustic signal is strictly different in shape from the waveform representing the modulation function, but the envelope has a rough shape similar to that of the waveform representing the modulation function (for example, a reverse sawtooth wave, a sawtooth wave, etc.). wavy or sinusoidal), and can provide the listener with the same auditory stimulus as when the sound pressure and frequency of the input acoustic signal are constant.
  • Example A An experiment in which the subject answers the discomfort when hearing multiple types of output sounds corresponding to different modulation functions and input acoustic signals
  • Example B Multiple types corresponding to different modulation functions and input acoustic signals
  • FIG. 7 is a diagram showing the results of the experiment.
  • the induction of gamma waves was confirmed in all modulated waveform patterns. Therefore, it can be expected that gamma waves are induced in the brain of the user US1 when the user US1 listens to the sound emitted from the sound output device 30 in the present embodiment. By inducing gamma waves in the brain of the user US1, an effect of improving the cognitive function of the user US1 (for example, treatment or prevention of dementia) can be expected. Further, it was confirmed that the waveform patterns of the first to third examples caused less discomfort than the waveform pattern of the fourth example.
  • the discomfort given to the listener when listening to the sound is suppressed more than when using the acoustic signal composed of a simple pulse wave. can be expected to be
  • FIG. 9 shows a list of sound stimuli (output sounds) used in this experiment.
  • Column 901 shows the identification number of the sound stimulus (hereinafter referred to as “stimulus number”)
  • column 902 shows the frequency of the sound signal (sine wave) before modulation
  • column 903 shows the presence or absence of modulation and the modulation function used for modulation.
  • column 904 shows the frequency of the modulation function
  • column 905 shows the modulation index.
  • m is the degree of modulation, and 0.00, 0.50 and 1.00 are used.
  • fm is a modulation frequency, and 20 Hz, 40 Hz and 80 Hz are used.
  • t is the time.
  • a sinusoidally modulated sound stimulus corresponds to the third example of the amplitude waveform described above.
  • stimulus numbers "07” and "08” are a sawtooth-wave-modulated sound stimulus and a reverse sawtooth-wave-modulated sound stimulus, respectively.
  • Envelopes of sawtooth wave modulation and inverse sawtooth wave modulation are represented by equations (2) and (3), respectively.
  • the modulation degree m was set to 1.00, and the modulation frequency fm was set to 40 Hz.
  • a sawtooth-wave-modulated sound stimulus and an inverse sawtooth-wave-modulated sound stimulus correspond to the second and first examples of amplitude waveforms described above, respectively.
  • the sawtooth function used here is a discontinuous function that repeatedly increases linearly from -1 to 1 and then instantly returns to -1.
  • the stimuli used in the experiments were adjusted to have equal equivalent noise levels (Laeq) after modulation.
  • the 40-Hz sine wave of stimulus number "01" has a sound pressure level 34.6 dB higher than that of 1 kHz when the equivalent noise level is uniform, but this makes the auditory loudness uniform.
  • Non-Patent Document 1 the stimulus used in the study of Non-Patent Document 1 (1 kHz sine wave with a taper of 0.3 ms before and after was repeated at a period of 40 Hz) was used as a comparison target ( stimulus number "09").
  • This pulse wave-like sound stimulation corresponds to the fourth example of the amplitude waveform described above.
  • This stimulus also had the same equivalent noise level as the stimulus numbers "01" to "08".
  • taper processing was applied for 0.5 seconds each before and after the stimulation. By performing the taper processing at the end in this manner, the equivalent noise level in the steady section is strictly maintained.
  • the duration of stimulation was 10 seconds for psychological experiments and 30 seconds for electroencephalogram measurements.
  • the experiment was conducted in the same quiet, magnetically shielded room as the electroencephalogram measurement experiment, with headphone presentation.
  • An LCD display was installed in front of the experiment participants, and a GUI was prepared for psychological evaluation. All responses were made by mouse operation.
  • the degree of discomfort and irritation when listening to each sound stimulus were evaluated on a 7-point scale. Playback was limited to one time, and the UI was designed so that no response could be given until the 10-second stimulus had finished playing. The next stimulus was set to play automatically when the response was completed. It was also designed to automatically prompt you to take a break in the middle of the experiment.
  • an electroencephalogram measurement (equivalent to experiment B above) was performed. Measurements were performed in a quiet, magnetically shielded room. The length of the stimulus used, including the taper, was 30 seconds. During the experiment, stimuli with the same treatment were presented twice. The interstimulus interval was 5 seconds, and the order of presentation was random. Experimental participants were instructed to move as little as possible and blink as little as possible during the presentation of the stimuli. In addition, a silent short animation video was played on an LCD monitor, and the level of consciousness was controlled to be constant and the level of attention to be stably lowered. Participants in the experiment were asked to choose a video from among those prepared in advance. In addition to the A1 and A2 reference electrodes, the experimental participants were provided with active electrodes at the positions of the Fp1, Fp2, F3, F4, T3, T4, T5, T6, Cz and Pz channels of the 10-20 method, respectively.
  • the measured EEG waveform was analyzed after the experiment. First, of the 30-second stimulus presentation interval, the area taper of 1 second before and after was excluded from the analysis target. After that, 55 sections of 1 second were cut out while shifting by 0.5 seconds. Since the same processing is performed twice, the analysis target is 110 sections. FFT was performed by applying a Hann window to each of these 110 waveforms. Since the window is moved half by half and the Hann window is applied, the data at all times are treated equally as a result.
  • FIG. 10 is a diagram showing experimental results of electroencephalogram evoked by sound stimulation. Specifically, FIG. 10 shows the power ratio of the 40 Hz component of the electroencephalogram evoked by each stimulus in the T6 channel. Values and error bars in the graph are the mean and standard deviation for all experimental participants. ANOVA confirmed a significant difference in stimulation (p ⁇ 0.01).
  • both the sawtooth wave modulation (stimulus number "07”) and the inverse sawtooth wave modulation (stimulus number "08") were significantly different from the unmodulated 1 kHz sine wave (stimulus number "05"). Also, no significant difference was found between these two stimuli. Therefore, it is shown that even a sound of 1 kHz, not a low frequency sound of 40 Hz, can induce a brain wave component of 40 Hz in the brain by setting the amplitude envelope curve of the modulation function to 40 Hz.
  • the pulsed stimulus (stimulus number '09') was also significantly different from the unmodulated 1 kHz sinusoidal wave (stimulus number '05').
  • FIG. 11 is a diagram showing the correlation between the results of psychological experiments and electroencephalogram measurements. Specifically, FIG. 11 shows the relationship between the degree of discomfort and the 40 Hz electroencephalogram component ratio.
  • stimulus number "08” which is a stimulus obtained by modulating a sine wave with a reverse sawtooth wave
  • the degree of discomfort is significantly lower than that of stimulus number "09”, but the 40 Hz electroencephalogram ratio
  • stimulation number "06” which is a stimulus obtained by modulating a sine wave with a sine wave of 80 Hz
  • the decrease in the degree of discomfort is small, but the decrease in the 40 Hz electroencephalogram is significant.
  • stimulus number "07” which is a sine wave modulated by sawtooth wave modulation, has lower discomfort and a 40-Hz electroencephalogram ratio than stimulus number "09", which is pulse-type stimulation.
  • the degree of discomfort is slightly higher and the 40 Hz electroencephalogram ratio is smaller.
  • Stimulus number "03” which is a stimulus obtained by modulating a 1 kHz sine wave with a 40 Hz sine wave at a modulation degree of 100%, has a lower discomfort level and a 40 Hz electroencephalogram ratio than stimulus number "09”, which is a pulse-type stimulus, and has a reverse sawtooth wave.
  • the degree of discomfort is slightly smaller and the 40 Hz electroencephalogram ratio is smaller.
  • FIG. 8 is a diagram showing the overall flow of acoustic signal processing by the signal processing device 10 of this embodiment.
  • the processing in FIG. 8 is implemented by the processor 12 of the signal processing device 10 reading and executing the program stored in the storage device 11 .
  • At least part of the processing in FIG. 8 may be realized by one or more dedicated circuits.
  • the acoustic signal processing in FIG. 8 is started when any of the following start conditions is satisfied. -
  • the audio signal processing of FIG. 8 was called by another process or an instruction from the outside.
  • the user performed an operation to call the acoustic signal processing in FIG. -
  • the signal processing device 10 has entered a predetermined state (for example, the power has been turned on). ⁇ The specified date and time has arrived. - A predetermined time has passed since a predetermined event (for example, activation of the signal processing device 10 or previous execution of the acoustic signal processing in FIG. 8).
  • the signal processing device 10 acquires an input acoustic signal (S110). Specifically, the signal processing device 10 receives an input acoustic signal sent from the sound source device 50 . In step S110, the signal processing device 10 may further perform A/D conversion of the input acoustic signal.
  • the input acoustic signal corresponds, for example, to at least one of the following.
  • - Music content e.g., singing, playing, or a combination thereof (i.e., music), which may include audio content that accompanies video content).
  • - Audio content for example, reading, narration, announcement, broadcast play, solo performance, conversation, monologue, or a combination thereof, etc., may include audio content accompanying video content
  • Other acoustic content e.g., electronic, ambient, or mechanical sounds
  • singing or audio content is not limited to sounds produced by human vocal organs, but may include sounds generated by speech synthesis technology.
  • the signal processing apparatus 10 determines the modulation method used to generate the output acoustic signal from the input acoustic signal acquired in step S110.
  • the modulation method determined here includes, for example, at least one of a modulation function used for modulation processing and a modulation index corresponding to the degree of amplitude change due to modulation.
  • the signal processing device 10 selects which one of the three types of modulation functions described with reference to FIGS. 4 to 6 is to be used. Which modulation function to select may be determined based on an input operation by the user or others, an instruction from the outside, or may be determined by an algorithm.
  • the other person is, for example, at least one of the following.
  • ⁇ The user's family, friends, or acquaintances ⁇ Medical personnel (for example, the user's doctor) - The creator or provider of the content corresponding to the input audio signal - The provider of the signal processing device 10 - The manager of the facility used by the user
  • the signal processing device 10 for example, the characteristics of the input acoustic signal (balance between voice and music, volume change, type of music, timbre, or other characteristics) and user attribute information (age, gender, hearing ability, cognitive function level,
  • the modulation method may be determined based on at least one of user identification information and other attribute information.
  • the signal processing apparatus 10 can determine the modulation method so that the effect of improving the cognitive function by modulation becomes higher, or determine the modulation method so as to make the user less uncomfortable.
  • the signal processing device 10 may determine the modulation method according to a timer. By periodically changing the modulation method according to the timer, it is possible to prevent the user from becoming accustomed to listening to the modulated sound, and to efficiently stimulate the user's brain. Further, the signal processing device 10 may determine the volume of the output acoustic signal according to various conditions, similar to determining the modulation method.
  • the signal processing apparatus 10 may decide not to perform modulation (that is, set the degree of modulation to 0) as one of the options for the modulation method. Further, the signal processing apparatus 10 may determine the modulation method so that the modulation is performed when a predetermined time has elapsed after the modulation method is determined so as not to perform the modulation. Furthermore, the signal processing apparatus 10 may determine the modulation method so that the degree of modulation gradually increases when changing from a state in which no modulation is performed to a state in which modulation is performed.
  • the signal processing apparatus 10 modulates the input acoustic signal (S112) to generate an output acoustic signal. Specifically, the signal processing apparatus 10 performs modulation processing according to the modulation method determined in S111 on the input acoustic signal acquired in S110. As an example, the signal processing device 10 amplitude-modulates the input acoustic signal using a modulation function having a frequency corresponding to a gamma wave (for example, a frequency of 35 Hz or more and 45 Hz or less). As a result, an amplitude change corresponding to the frequency is added to the input acoustic signal. In step S112, the signal processing device 10 may further perform at least one of amplification, volume control, and D/A conversion of the output acoustic signal.
  • the signal processing device 10 transmits an output acoustic signal (S113). Specifically, the signal processing device 10 sends the output sound signal generated in step S112 to the sound output device 30 . The sound output device 30 generates sound according to the output sound signal. The signal processing device 10 ends the acoustic signal processing in FIG. 8 at step S113.
  • the signal processing apparatus 10 may collectively perform the processing in FIG. 8 for an input sound signal having a certain reproduction period (for example, music content of one piece of music), or may perform the processing for each predetermined reproduction period of the input sound signal. The process of FIG. 8 may be repeated (for example, every 100 ms).
  • the signal processing device 10 may continuously perform modulation processing on an input acoustic signal, such as modulation by analog signal processing, and output a modulated acoustic signal.
  • the processing shown in FIG. 8 is terminated according to a specific termination condition (for example, a certain period of time has passed, a user operation has been performed, or the output history of modulated sound has reached a predetermined state). You may The order of processing by the signal processing device 10 is not limited to the example shown in FIG. 8, and for example, the determination of the modulation method (S111) may be performed before the acquisition of the input acoustic signal (S110).
  • the signal processing apparatus 10 of the present embodiment performs amplitude modulation on an input acoustic signal to generate an output acoustic signal having an amplitude change corresponding to the gamma wave frequency. Generate. In the output acoustic signal, the rise and fall of the envelope of the amplitude waveform are asymmetrical.
  • the signal processing device 10 outputs the generated output acoustic signal to the acoustic output device 30 .
  • the amplitude of the acoustic signal can be increased or decreased in a predetermined cycle while suppressing discomfort given to the listener.
  • the sound output device 30 causes the user to listen to the sound corresponding to the output sound signal, thereby inducing gamma waves in the user's brain due to fluctuations in the amplitude of the output sound signal.
  • the effect of improving the user's cognitive function for example, treating or preventing dementia
  • the output acoustic signal may have amplitude changes corresponding to frequencies between 35 Hz and 45 Hz. As a result, when the user hears the sound corresponding to the output acoustic signal, it can be expected that gamma waves will be induced in the user's brain.
  • the input audio signal may be an audio signal corresponding to music content.
  • the motivation of the user to listen to the sound corresponding to the output acoustic signal can be improved.
  • the storage device 11 may be connected to the signal processing device 10 via the network NW.
  • the display 21 may be built in the signal processing device 10 .
  • the signal processing device 10 may extract a part of the acoustic signal from the input acoustic signal, modulate only the extracted acoustic signal, and then generate the output acoustic signal.
  • the signal processing device 10 modulates an input acoustic signal and generates an output acoustic signal is sent to the acoustic output device 30 .
  • the signal processing device 10 generates an output acoustic signal by synthesizing a modulated input acoustic signal obtained by modulating the input acoustic signal with other acoustic signals, and converts the generated output acoustic signal into an acoustic signal. It may be sent to the output device 30 . Further, the signal processing device 10 may send the modulated input acoustic signal and other acoustic signals to the acoustic output device 30 at the same time without synthesizing them.
  • the envelope of the amplitude waveform is a reverse sawtooth wave or a sawtooth wave, and the rise and fall of the envelope are asymmetrical.
  • the output acoustic signal generated by the signal processing device 10 is not limited to these, and may have other amplitude waveforms in which the rise and fall of the envelope of the amplitude waveform are asymmetrical.
  • the slope of the tangent to the envelope may gradually decrease, or the slope of the tangent to the envelope may gradually increase.
  • the slope of the tangent to the envelope may gradually decrease, or the slope of the tangent to the envelope may gradually increase.
  • the modulation function has a frequency of 35 Hz or more and 45 Hz or less
  • the modulation function used by the signal processing device 10 is not limited to this, and any modulation function that affects the induction of gamma waves in the brain of the listener may be used.
  • the modulation function may have frequencies between 25 Hz and 140 Hz.
  • the frequency of the modulating function may change over time, and the modulating function may have a frequency below 35 Hz or a frequency above 45 Hz in part.
  • the output sound signal generated by the signal processing device 10 is output to the sound output device 30 that emits a sound corresponding to the output sound signal and is heard by the user.
  • the output destination of the output acoustic signal by the signal processing device 10 is not limited to this.
  • the signal processing device 10 may output the output acoustic signal to an external storage device or information processing device via a communication network or by broadcasting.
  • the signal processing device 10 may output the input acoustic signal that has not been modulated together with the output acoustic signal generated by the modulation processing to an external device.
  • the external device can arbitrarily select and reproduce one of the unmodulated acoustic signal and the modulated acoustic signal.
  • the signal processing device 10 may output information indicating the content of modulation processing to an external device together with the output acoustic signal.
  • Information indicating the content of modulation processing includes, for example, any of the following.
  • Information indicating the modulation function Information indicating the degree of modulation Information indicating the volume With this, the external device can change the reproduction method of the acoustic signal according to the content of the modulation processing. Further, when the signal processing device 10 acquires additional information (for example, an ID3 tag in an MP3 file) together with the input sound signal, the signal processing device 10 may change the additional information and output it to the external device together with the output sound signal.
  • Non-Patent Document 1 discloses that when 40-Hz sound stimulation induces gamma waves in the brain, amyloid ⁇ is reduced and cognitive function is improved. That is, by making the user hear the sound corresponding to the output acoustic signal output by the signal processing device 10, the amount of amyloid ⁇ in the brain of the user is reduced and the deposition is suppressed. It is expected to be useful for the prevention or treatment of various diseases.
  • CAA cerebral amyloid angiopathy
  • CAA is a disease in which amyloid ⁇ protein deposits on the walls of small blood vessels in the brain, making the walls of blood vessels fragile and causing cerebral hemorrhage and the like.
  • the technology described in the above embodiments can be an innovative therapeutic method. That is, the sound system 1 comprising the signal processing device 10 and the sound output device 30 for allowing the user to hear a sound corresponding to the output sound signal output by the signal processing device 10 is used for treatment or prevention of cerebral amyloid angiopathy. It can also be used as a medical system for
  • Sound system 10 Signal processing device 11: Storage device 12: Processor 13: Input/output interface 14: Communication interface 21: Display 30: Sound output device 50: Sound source device

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