WO2023062182A1 - Compositions de vaccin contre le virus de la diarrhée virale bovine - Google Patents

Compositions de vaccin contre le virus de la diarrhée virale bovine Download PDF

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Publication number
WO2023062182A1
WO2023062182A1 PCT/EP2022/078616 EP2022078616W WO2023062182A1 WO 2023062182 A1 WO2023062182 A1 WO 2023062182A1 EP 2022078616 W EP2022078616 W EP 2022078616W WO 2023062182 A1 WO2023062182 A1 WO 2023062182A1
Authority
WO
WIPO (PCT)
Prior art keywords
protein
pvp2
seq
sequence
ibdv
Prior art date
Application number
PCT/EP2022/078616
Other languages
English (en)
Inventor
Marta GARCÍA DÍEZ
Ester HEVIA LÓPEZ
Ana GÓMEZ RODRÍGUEZ
Pablo GUTIÉRREZ GÓMEZ
Original Assignee
Aquilón Cyl, S.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aquilón Cyl, S.L. filed Critical Aquilón Cyl, S.L.
Publication of WO2023062182A1 publication Critical patent/WO2023062182A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/10011—Birnaviridae
    • C12N2720/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Abstract

L'invention concerne un polypeptide antigénique dérivé de la protéine E2 du virus de la diarrhée virale bovine, une protéine de fusion comprenant ledit polypeptide et une particule de type viral comprenant ladite protéine de fusion. L'invention concerne également une composition de vaccin comprenant ladite particule de type viral et son utilisation médicale.
PCT/EP2022/078616 2021-10-15 2022-10-14 Compositions de vaccin contre le virus de la diarrhée virale bovine WO2023062182A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP21382933 2021-10-15
EP21382933.6 2021-10-15

Publications (1)

Publication Number Publication Date
WO2023062182A1 true WO2023062182A1 (fr) 2023-04-20

Family

ID=78516741

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2022/078616 WO2023062182A1 (fr) 2021-10-15 2022-10-14 Compositions de vaccin contre le virus de la diarrhée virale bovine

Country Status (1)

Country Link
WO (1) WO2023062182A1 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070015243A1 (en) * 2005-07-15 2007-01-18 Consejo Superior De Investigaciones Cientificas And Bionostra S.L. Chimeric empty viral-like particles derived from the infectious bursal disease virus (IBDV), process for their production and applications
CN112961224A (zh) * 2021-03-26 2021-06-15 中国农业大学 牛病毒性腹泻病毒1型病毒样颗粒的制备及应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070015243A1 (en) * 2005-07-15 2007-01-18 Consejo Superior De Investigaciones Cientificas And Bionostra S.L. Chimeric empty viral-like particles derived from the infectious bursal disease virus (IBDV), process for their production and applications
WO2007009673A1 (fr) 2005-07-15 2007-01-25 Consejo Superior De Investigaciones Científicas Particules chimeriques vides d'apparence virale tirees du virus de la bursite infectieuse (ibdv), procede de production et applications
CN112961224A (zh) * 2021-03-26 2021-06-15 中国农业大学 牛病毒性腹泻病毒1型病毒样颗粒的制备及应用

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
"NCBI", Database accession no. AAD30136
"Servei de Granges I Camps Experimentals", UNIVERSITAT AUTONOMA DE BARCELONA (UAB
"UniProtKB", Database accession no. AOFKE612
ALTSCHUL ET AL., NUCLEIC ACIDS RES, vol. 25, 1997, pages 3389
ALTSCHUL, S. ET AL., J MOL BIOL, vol. 215, 1990, pages 403 - 410
SANCHEZ ABRODRIGUEZ JF: "Proteolytic processing in infectious bursal disease virus: identification of the polyprotein cleavage sites by site-directed mutagenesis", VIROLOGY, vol. 262, no. 1, 15 September 1999 (1999-09-15), pages 190 - 199, XP004439831, DOI: 10.1006/viro.1999.9910
SANGEWAR NEHA ET AL: "Novel Potent IFN-[gamma]-Inducing CD8 + T Cell Epitopes Conserved among Diverse Bovine Viral Diarrhea Virus Strains", vol. 206, no. 8, 15 April 2021 (2021-04-15), US, pages 1709 - 1718, XP055915630, ISSN: 0022-1767, Retrieved from the Internet <URL:https://www.jimmunol.org/content/jimmunol/206/8/1709.full.pdf> [retrieved on 20220426], DOI: 10.4049/jimmunol.2001424 *
VAN DEN BERG TP ET AL., REV SCI TECH, vol. 19, 2000, pages 509 - 43
WANG ZHANHUI ET AL: "Induction of Robust and Specific Humoral and Cellular Immune Responses by Bovine Viral Diarrhea Virus Virus-Like Particles (BVDV-VLPs) Engineered with Baculovirus Expression Vector System", vol. 9, no. 4, 6 April 2021 (2021-04-06), pages 1 - 15, XP055915269, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067437/pdf/vaccines-09-00350.pdf> [retrieved on 20220426], DOI: 10.3390/vaccines9040350 *

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