WO2023060472A1

WO2023060472A1 - Non-irritating, foam-type and handwashing-free moisturizing antibacterial liquid and preparation method therefor

Info

Publication number: WO2023060472A1
Application number: PCT/CN2021/123516
Authority: WO
Inventors: 费丽坤; 鲁建国; 钱海波
Original assignee: 振德医疗用品股份有限公司
Priority date: 2021-10-13
Filing date: 2021-10-13
Publication date: 2023-04-20
Also published as: CN115052578A

Abstract

A non-irritating, foam-type and handwashing-free moisturizing antibacterial liquid of the present invention does not contain any chemical disinfection active components. The antibacterial active component thereof is mild and non-irritating, and can be used by pregnant women and children without worry, such that the daily hand cleaning and antibacterial functions of different groups of people are met. The addition of a moisturizing component can better protect the skin of the hands. The antibacterial liquid can be carried around and used for cleaning and bacteriostasis anytime and anywhere without needing to wash with water. The present invention provides a non-irritating, foam-type and handwashing-free moisturizing antibacterial liquid, which comprises the following components: an antibacterial agent, a moisturizing agent, a foaming agent, a pH regulator, and a solvent.

Description

A kind of moisturizing and non-irritating foam type hand-washing antibacterial liquid and preparation method thereof

technical field

The invention belongs to the technical field of antibacterial products, and relates to a bacteriostatic solution, in particular to a moisturizing and non-irritating foam that does not contain cationic disinfection components such as quaternary ammonium salts and cationic surfactants such as cocamidopropyl betaine Hand-free antibacterial liquid and preparation method thereof.

Background technique

In the civilized era of current social development, people have higher and higher requirements for hygiene standards. When people travel or participate in various activities in public places, they need to be in frequent contact with various environments, and inevitably come into contact with a large number of bacteria, fungi and viruses. In order to avoid infection, timely disinfection is particularly important, especially hand disinfection. In order to solve people's needs, water-free hand sanitizer/antibacterial liquid/antibacterial liquid came into being. At present, there are mainly three dosage forms on the market: one is water, the other is gel, and the other is foam.

There are a lot of water-free hand sanitizers (disinfectants) on the domestic and foreign markets, and most of them are gel-type water-free hand sanitizers (accounting for more than 90%) containing alcohol. Because it contains alcohol, this hand sanitizer has certain irritation , especially people with allergies, not only that, but its smell is very pungent, there are safety hazards in storage, transportation and use, and a fire will break out when it encounters an open flame.

Affected by the outbreak of the epidemic, the demand for hand disinfection products will continue to increase, the output of hand disinfection products will increase significantly, and further subdivided products that meet people's daily hand disinfection and hand maintenance needs will appear.

Hand sanitizers come in many forms, the most common being liquid. In recent years, foam and gel hand sanitizers have sprung up, enriching the market demand.

Foam-type hand sanitizer, compared with liquid hand sanitizer, saves the action of rubbing and foaming, and at the same time avoids the waste of hand sanitizer caused by insufficient foaming of liquid hand sanitizer.

Compared with liquid hand sanitizers, foam-type hand sanitizers have obvious advantages in experience, while disposable hand sanitizers have the advantage of convenience. At present, most hand sanitizer brands have launched foam-type hand sanitizers and disposable hand sanitizers. In recent years, the sales of foam hand sanitizers have maintained double-digit growth, which is higher than the demand for liquid hand sanitizers.

Through the collection of information on foam-type hand sanitizers that have been filed, it is found that some of the current foam-type hand sanitizers are mainly composed of cationic disinfectants that can generate foam, such as quaternary ammonium salts, but quaternary ammonium salts have certain Corrosion is corrosive to medical devices and metal products. At the same time, quaternary ammonium salt products contain certain irritation, and the quality of different brands of products is uneven, so there is a certain risk. Another part of the product is the addition of surfactants such as cocamidopropyl betaine that can generate rich foam, but this type of product is an ingredient in body wash, hand sanitizer, foam cleanser, etc., and household detergents. The common feature of the products is that because of their irritating ingredients, they will not stay on the skin surface, and they will be rinsed off with clean water after use.

Therefore existing foam-type hand-washing antibacterial liquid needs to be changed from formula, guarantees its safety, effectiveness and nonirritant.

Contents of the invention

The purpose of the present invention is to solve the existing foam-type hand-free antibacterial liquid because of containing cationic disinfectant components such as quaternary ammonium salts or because of containing surfactants such as cocamidopropyl betaine and have certain irritation, stay The defect of time is short, and provide a kind of moisturizing non-irritating foam type hand-washing antibacterial liquid and preparation method thereof not containing cationic disinfection composition such as quaternary ammonium salt etc. and cationic surfactant such as cocamidopropyl betaine etc.

In order to achieve the above object, the present invention adopts the following technical solutions:

A moisturizing and non-irritating foam-type hand-washing antibacterial liquid, comprising the following components by weight fraction: 0.01-0.50% of antibacterial agent, 2-20% of moisturizing agent, 0.01-0.50% of foaming agent, and 0.01-0.50 of pH regulator %, and the rest are solvents.

As a preferred version of the present invention, it comprises the following components by weight fraction: bacteriostatic agent 0.01-0.20%, moisturizing agent 2-15%, foaming agent 0.01-0.30%, pH regulator 0.01-0.30%, and the rest are solvent.

As a preferred version of the present invention, it comprises the following components by weight fraction: bacteriostatic agent 0.01-0.10%, moisturizing agent 2-10%, foaming agent 0.01-0.10%, pH regulator 0.01-0.10%, and the rest are solvent.

As a preferred solution of the present invention, the bacteriostatic agent is at least one of hexamidine diisethionate, borneol camphor extract or polylysine.

When the antibacterial agent is a mixture of hexamidine diisethionate, borneol camphor extract and polylysine, hexamidine diisethionate, borneol camphor extract and polylysine The mass ratio of acid is (1:1:1)-(5:2:1).

As a preferred solution of the present invention, the humectant is at least one of acetylglucosamine or glycerol glucoside.

When the humectant is a mixture of acetylglucosamine and glycerol glucoside, the mass ratio is (1:1)-(2:5).

As a preferred version of the present invention, the foaming agent is sodium cocoyl glycinate.

As a preferred solution of the present invention, the pH regulator is hydrochloric acid or sodium hydroxide.

As a preferred solution of the present invention, the solvent is purified water.

A preparation method of moisturizing non-irritating foam type hand-washing antibacterial liquid, said preparation method may further comprise the steps:

1) Weigh the antibacterial agent according to the formula amount, add purified water, fully stir and disperse to obtain solution A;

2) Weigh the moisturizing agent and the foaming agent according to the formula amount, add them to the solution A obtained in step 1), and fully stir to obtain the solution B;

3) Weigh the pH adjuster according to the formula and add it to the solution B obtained in step 2), stir well, supplement it with purified water and stir evenly to obtain a moisturizing and non-irritating foam-type hand-washing antibacterial liquid.

As a preferred solution of the present invention, in step 2) and step 3), the stirring time is 45-60min.

Compared with the prior art, the present invention has the following beneficial effects:

1) The moisturizing and non-irritating foam-type hand-washing antibacterial liquid of the present invention has a moisturizing effect, can effectively protect hands, and produces rich and delicate foam at the same time, and antibacterial and moisturizing effects are simultaneously effective;

2) the hand-free antibacterial liquid of the present invention has no irritation to the skin;

3) The hand-free antibacterial liquid of the present invention can stay on the skin surface without washing with water;

4) The hand-free antibacterial liquid of the present invention is applicable to all kinds of crowds such as pregnant women, infants and young children;

5) The composition of the hand-free antibacterial liquid of the present invention is safe and non-irritating.

Detailed ways

The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Apparently, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

Example 1

The present embodiment provides a moisturizing, non-irritating, foam type hand-washing antibacterial liquid, comprising the following components by weight percentage: 0.05% antibacterial agent, 10% moisturizing agent, 0.01% foaming agent, and 0.01% pH regulator , and the rest are solvents.

Among them, the main component of the antibacterial agent is hexamidine diisethionate with a content of 0.05%, the moisturizing agent is acetylglucosamine with a content of 10%, the foaming agent is sodium cocoyl glycinate, and the pH regulator is hydrochloric acid, sodium hydroxide;

The preparation method comprises the following steps:

1) Weigh the bacteriostatic agent according to the formula quantity in a container of an appropriate amount of purified water, fully stir and disperse to obtain solution A;

2) Weigh the moisturizing agent according to the formula amount and add it to the solution A obtained in step 1), and stir thoroughly to obtain the solution B;

3) Weigh the pH regulator according to the formula amount and add it to the solution B obtained in step 3), stir well, make up with purified water, and stir evenly to obtain a moisturizing, non-irritating, foam-type hand-washing antibacterial liquid.

Example 2

The present embodiment provides a moisturizing, non-irritating, foam type hand-washing antibacterial solution, comprising the following components by weight percentage: 0.05% antibacterial agent, 10% moisturizing agent, 0.015% foaming agent, and 0.012% pH regulator , and the rest are solvents.

Among them, the main components of the antibacterial agent are hexamidine diisethionate and borneol camphor extract, the ratio is 3:2; the moisturizing agent is glycerol glucoside; the foaming agent is sodium cocoyl glycinate; the pH regulator The ratio of hydrochloric acid and sodium hydroxide is 1:1;

The preparation method comprises the following steps:

Example 3

The present embodiment provides a moisturizing, non-irritating, foam-type hand-washing antibacterial liquid, comprising the following components by weight percentage: 0.03% antibacterial agent, 8% moisturizing agent, 0.02% foaming agent, and 0.015% pH regulator , and the rest are solvents.

Among them, the main components of the antibacterial agent are hexamidine diisethionate, borneol camphor extract and polylysine, the ratio is 5:2:1; the moisturizing agent is a mixture of acetyl glucosamine and glycerol glucoside. The mixture has a mass ratio of 3:2; the foaming agent is sodium cocoyl glycinate; the pH regulator is hydrochloric acid and sodium hydroxide in a ratio of 1:1;

The preparation method comprises the following steps:

Moisturizing, non-irritating, foam-type hand-washing antibacterial liquid that the present invention makes, through comparative example 1-3, the effect of embodiment 3 is better, and moisturizing performance and antibacterial performance are all better than embodiment 1 and 2 , see Table 1 and Table 2 for details.

Table 1. In vitro moisturizing rate effect test of embodiment 1-3

Table 2. The antibacterial effect of embodiment 1-3 on Staphylococcus aureus, Escherichia coli, Candida albicans

As can be seen from Table 1 and Table 2, referring to Wu Yanyan, Zhang Wan and others from the South China Sea Fisheries Research Institute of the Chinese Academy of Fishery Sciences, published in the natural product research and development "Analysis of the absorption and moisturizing effect of MAAs in seaweed "In the method of 1.3.2 Determination of moisturizing ability of seaweed MAAs, the experiment operation was carried out, and the moisturizing effect of embodiment 3 was obviously better than that of embodiments 1 and 2.

According to " standardization of disinfection technology " 2.1.11.3.2 stripping property anti-(inhibition) bacteriostasis test method, carry out antibacterial rate detection, moisturizing, non-irritating, foam type hand-washing antibacterial liquid that embodiment 3 makes is right to golden yellow The antibacterial rate of Staphylococcus, Escherichia coli and Candida albicans is greater than 99.9%, and the results meet the requirements of GB15979 "Hygienic Standards for Disposable Sanitary Products".

It can be seen that the moisturizing and non-irritating foam-type hand-washing antibacterial liquid of the present invention does not contain any chemical disinfection active ingredients, and the antibacterial active ingredients are mild and non-irritating. Pregnant women and children can safely use the composition to meet the needs of different groups of people. The antibacterial function of daily hand cleaning and the addition of moisturizing ingredients can better protect the skin of the hands. It can be carried with you, and it can be cleaned and antibacterial anytime and anywhere without washing.

The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any form and in essence. Several improvements and supplements can be made, and these improvements and supplements should also be regarded as the protection scope of the present invention. Those who are familiar with this profession, without departing from the spirit and scope of the present invention, when they can use the technical content disclosed above to make some changes, modifications and equivalent changes of evolution, are all included in the present invention. Equivalent embodiments; at the same time, all changes, modifications and evolutions of any equivalent changes made to the above-mentioned embodiments according to the substantive technology of the present invention still belong to the scope of the technical solution of the present invention.

Claims

A moisturizing and non-irritating foam-type hand-free antibacterial liquid is characterized in that it comprises the following components by weight fraction: 0.01-0.50% of antibacterial agent, 2-20% of moisturizing agent, 0.01-0.50% of foaming agent, pH adjustment Agent 0.01-0.50%, the rest is solvent.
A kind of moisturizing non-irritating foam type hand-free antibacterial liquid according to claim 1, characterized in that it comprises the following components by weight fraction: bacteriostatic agent 0.01-0.20%, moisturizing agent 2-15%, foaming agent 0.01-0.30%, pH regulator 0.01-0.30%, and the rest are solvents.
A kind of moisturizing non-irritating foam type hand-free antibacterial liquid according to claim 1, characterized in that, it comprises the following components by weight fraction: bacteriostatic agent 0.01-0.10%, moisturizing agent 2-10%, foaming agent 0.01-0.10%, pH regulator 0.01-0.10%, and the rest are solvents.
According to claim 1 or 2 or 3 described a kind of moisturizing non-irritating foam type hand-free antibacterial liquid, it is characterized in that, the described antibacterial agent is hexamidine diisethionate, borneol camphor extract or at least one of polylysine.
A kind of moisturizing non-irritating foam type hand-washing antibacterial liquid according to claim 1, 2 or 3, wherein the moisturizing agent is at least one of acetylglucosamine or glycerol glucoside.
A kind of moisturizing non-irritating foam type hand-washing antibacterial liquid according to claim 1, 2 or 3, wherein said foaming agent is sodium cocoyl glycinate.
A kind of moisturizing non-irritating foam type hand-washing antibacterial liquid according to claim 1, 2 or 3, wherein the pH regulator is hydrochloric acid or sodium hydroxide.
A kind of moisturizing non-irritating foam type hand-washing antibacterial liquid according to claim 1, 2 or 3, wherein the solvent is purified water.
A preparation method of the moisturizing non-irritating foam type hand-washing antibacterial liquid as described in any one of claims 1-8, is characterized in that, described preparation method comprises the following steps:

1) Weigh the antibacterial agent according to the formula amount, add purified water, fully stir and disperse to obtain solution A;

2) Weigh the moisturizing agent and the foaming agent according to the formula amount, add them to the solution A obtained in step 1), and fully stir to obtain the solution B;

3) Weigh the pH adjuster according to the formula and add it to the solution B obtained in step 2), stir well, supplement it with purified water and stir evenly to obtain a moisturizing and non-irritating foam-type hand-washing antibacterial liquid.
The preparation method of moisturizing non-irritating foam type hand-washing antibacterial liquid according to claim 9 is characterized in that, in step 2) and step 3), the stirring time is 45-60min.