WO2023056712A1 - Blood analysis apparatus and blood analysis method for animals - Google Patents

Abstract

A blood analysis apparatus and blood analysis method for animals. The method comprises: acquiring the current animal measurement mode, wherein the blood analysis method has a plurality of animal measurement modes, and the animal measurement modes have mode feature parameters; preparing a sample by means of a blood sample and a reagent; testing the sample to obtain a test signal; according to the test signal, obtaining the value of the blood sample at a mode feature parameter of the current animal measurement mode, and according to the value of the blood sample at the mode feature parameter of the current animal measurement mode, determining whether the current animal measurement mode is wrongly selected; and when it is determined that the current animal measurement mode is wrongly selected, executing a predetermined operation for when the animal measurement mode is wrongly selected. By means of the present invention, it is possible to determine when a wrong animal measurement mode is set for a blood sample.

Description

Animal blood analysis device and blood analysis method technical field

The present invention relates to a blood analysis device for animals and a blood analysis method.

Background technique

Routine blood examination is one of the most basic laboratory tests in clinical practice. By observing the changes in the number and morphology of blood cells, it can be used to judge the condition of blood and diseases. Routine blood tests mainly include red blood cells, white blood cells, hemoglobin, and platelets.

Animal blood analysis devices based on the detection of animal blood samples can usually measure the blood of various animals. When users use the instrument to detect samples, they need to select the corresponding animal type first, and the instrument will analyze the current sample according to the animal type selected by the user. For measurement, when the user selects or sets the wrong animal type, it may affect the measurement results, and then affect the clinical diagnosis results.

technical problem

In view of the above problems, the present invention provides an animal blood analysis device and a blood analysis method, which will be described in detail below.

technical solution

According to the first aspect, an embodiment provides a blood analysis device for animals, comprising:

A blood sample supply part, used for supplying blood samples;

a reagent supply part, used for supplying reagents;

a reaction part, configured to receive the blood sample provided by the blood sample supply part and the reagent provided by the reagent supply part to prepare a sample;

a measurement unit, configured to measure the sample to obtain a measurement signal;

The animal measurement mode selection part is used to select one of various animal measurement modes as the current animal measurement mode;

a processor, configured to analyze the measurement signal to obtain blood analysis results;

in:

The animal measurement mode has a mode characteristic parameter; the processor is also used to obtain the value of the mode characteristic parameter of the blood sample in the currently selected animal measurement mode according to the measurement signal, and according to the value of the mode characteristic parameter Judging whether the current animal measurement mode is wrongly selected; when the processor judges that the current animal measurement mode is wrongly selected, perform a predetermined operation when the animal measurement mode is wrongly selected.

In an embodiment, the measurement signal includes at least two kinds of optical signals; the mode characteristic parameter includes particle distribution in a preset area of a particle scatter diagram generated based on the at least two kinds of optical signals;

The processor obtains the particle distribution of the blood sample in the preset area of the particle scattergram according to the measurement signal;

The processor judges whether the particle distribution of the blood sample in the particle scattergram in the preset area conforms to the currently selected animal measurement mode in the particle scattergram in the preset area. Preset particle distribution;

If not, the processor judges that the current animal measurement mode selection is wrong.

In one embodiment, the particle distribution in the preset area of the particle scattergram includes the number of particle clusters.

The processor obtains the number of particle clusters of the blood sample in a preset area of the particle scatter diagram according to the measurement signal;

The processor judges whether the number of particle clusters of the blood sample in the preset area of the particle scattergram is equal to the preset particle number of the currently selected animal measurement mode in the preset area of the particle scattergram number of groups;

If not, the processor judges that the current animal measurement mode selection is wrong.

In one embodiment, the at least two kinds of light signals include side scattered light and fluorescence.

In one embodiment, the model characteristic parameters include mean red blood cell volume results;

The processor obtains the mean corpuscular volume result of the blood sample according to the measurement signal;

The processor judges whether the mean red blood cell volume result of the blood sample is within the preset mean red blood cell volume result range of the currently selected animal measurement mode;

If not, the processor judges that the current animal measurement mode selection is wrong.

In one embodiment, the predetermined operation performed by the processor when the selection of the animal measurement mode is wrong includes at least one of the following:

The processor generates a prompt that the animal model is selected incorrectly;

The processor also judges the animal measurement mode matched by the current blood sample according to the characteristic parameters, and generates a corresponding prompt;

The processor also judges the animal measurement mode matched by the current blood sample according to the characteristic parameters, and retests the current blood sample according to the animal measurement mode.

In one embodiment, the multiple animal measurement modes include at least a cat measurement mode and a dog measurement mode.

According to a second aspect, an embodiment provides a blood analysis method, comprising:

Obtain the current animal measurement mode; wherein the blood analysis method has multiple animal measurement modes, and the animal measurement mode has mode characteristic parameters;

Sample preparation from blood samples and reagents;

assaying the sample to obtain an assay signal;

Obtain the value of the mode characteristic parameter of the blood sample in the current animal measurement mode according to the measurement signal, and judge whether the current animal measurement mode is selected according to the value of the mode characteristic parameter of the blood sample in the current animal measurement mode mistake;

When it is judged that the current animal measurement mode is wrongly selected, a predetermined operation is performed when the animal measurement mode is wrongly selected.

In an embodiment, the measurement signal includes at least two kinds of optical signals; the mode characteristic parameter includes particle distribution in a preset area of a particle scatter diagram generated based on the at least two kinds of optical signals;

The judging whether the current animal measurement mode is wrongly selected includes:

Obtaining the particle distribution of the blood sample in the preset area of the particle scattergram according to the measurement signal;

judging whether the particle distribution of the blood sample in the particle scattergram in the preset area conforms to the preset particle distribution in the particle scattergram in the preset area of the currently selected animal measurement mode Condition;

If not, it is judged that the current animal measurement mode is wrongly selected.

In one embodiment, the model characteristic parameters include mean red blood cell volume results;

The judging whether the current animal measurement mode is wrongly selected includes:

Obtaining the mean corpuscular volume result of the blood sample according to the determination signal;

judging whether the mean corpuscular volume result of the blood sample is within the preset mean corpuscular volume result range of the currently selected animal measurement mode;

If not, it is judged that the current animal measurement mode selection is wrong.

In an embodiment, the predetermined operation includes at least one of the following:

Generate an error prompt for animal mode selection;

Judging the animal measurement mode matched by the current blood sample according to the characteristic parameters, and generating a corresponding prompt;

The animal measurement mode matched by the current blood sample is judged according to the characteristic parameters, and the current blood sample is retested according to the animal measurement mode.

In one embodiment, the multiple animal measurement modes include at least a cat measurement mode and a dog measurement mode.

Beneficial effect

According to the animal blood analysis device and the blood analysis method of the above embodiments, the value of the mode characteristic parameter of the blood sample in the current animal measurement mode is obtained according to the measurement signal, and the value of the mode characteristic parameter of the blood sample in the current animal measurement mode is obtained. , judging whether the current animal measurement mode is selected incorrectly, so that it can be judged that the blood sample is set to the wrong animal measurement mode.

Description of drawings

Fig. 1(a) and Fig. 1(b) are a list of test results of 8 cases of dog blood samples in the animal blood analysis device respectively selecting the dog measurement mode and the cat measurement mode;

Fig. 2(a) and Fig. 2(b) are a list of test results of 8 cases of cat blood samples in the animal blood analysis device respectively selecting the cat measurement mode and the dog measurement mode;

Fig. 3 is a schematic structural diagram of an animal blood analysis device according to an embodiment;

Fig. 4 is a schematic structural diagram of an animal blood analysis device according to an embodiment;

Fig. 5 is a schematic structural diagram of an optical detection part of an embodiment;

Fig. 6 is a schematic structural diagram of an optical detection part of an embodiment;

Fig. 7 is a schematic structural diagram of an optical detection part of an embodiment;

Fig. 8 is a schematic diagram of the interface setting of the animal measurement mode of an embodiment;

Fig. 9 is an example of a scattergram of DIFF channel classification results after a dog blood sample is detected in the dog measurement mode of the blood analysis device for animals in an embodiment;

Fig. 10 is an example of a scattergram of DIFF channel classification results after a cat blood sample is detected in the cat measurement mode of an animal blood analysis device in an embodiment;

Fig. 11 is an example of a scattergram of DIFF channel classification results after a dog blood sample is detected in the cat measurement mode of the blood analysis device for animals in an embodiment;

Fig. 12 is an example of a scattergram of DIFF channel classification results after a cat blood sample is detected in the dog measurement mode of an animal blood analysis device in an embodiment;

Fig. 13 is a flowchart of a blood analysis method in an embodiment.

Embodiments of the present invention

The present invention will be further described in detail below through specific embodiments in conjunction with the accompanying drawings. Wherein, similar elements in different implementations adopt associated similar element numbers. In the following implementation manners, many details are described for better understanding of the present application. However, those skilled in the art can readily recognize that some of the features can be omitted in different situations, or can be replaced by other elements, materials, and methods. In some cases, some operations related to the application are not shown or described in the description, this is to avoid the core part of the application being overwhelmed by too many descriptions, and for those skilled in the art, it is necessary to describe these operations in detail Relevant operations are not necessary, and they can fully understand the relevant operations according to the description in the specification and general technical knowledge in the field.

In addition, the characteristics, operations or characteristics described in the specification can be combined in any appropriate manner to form various embodiments. At the same time, the steps or actions in the method description can also be exchanged or adjusted in a manner obvious to those skilled in the art. Therefore, various sequences in the specification and drawings are only for clearly describing a certain embodiment, and do not mean a necessary sequence, unless otherwise stated that a certain sequence must be followed.

The serial numbers assigned to components in this document, such as "first", "second", etc., are only used to distinguish the described objects, and do not have any sequence or technical meaning. The "connection" and "connection" mentioned in this application include direct and indirect connection (connection) unless otherwise specified.

In one scheme, after the user selects or sets the corresponding animal measurement mode for the current sample in the animal blood analysis device, the animal blood analysis device will call the processing algorithm of the corresponding animal measurement mode to measure and analyze the current sample. analysis to get the corresponding analysis results.

Inventor randomly selected 8 For example, after the blood sample of a dog is tested in the dog measurement mode and cat measurement mode on the animal blood analysis device, the results are shown in the figure 1 ( a ) and figure 1 ( b ), the inventor also randomly selected 8 For example, after the blood sample of a cat is tested in the cat measurement mode and the dog measurement mode on the animal blood analysis device, the results are shown in the figure 2 ( a ) and figure 2 ( b ). The inventors found that, for an animal blood analysis device, selecting or setting the correct sample type (ie, the animal measurement mode) before measurement has a great influence on the measurement results and final clinical diagnosis results. Therefore, the inventor considers proposing a solution to detect whether the user correctly sets or selects the sample type, and gives an error prompt to avoid the occurrence of clinical accidents. in the chart WBC refers to white blood cells, RBC refers to red blood cells, HCT refers to the hematocrit, MCV is the mean corpuscular volume, MCHC is the mean corpuscular hemoglobin concentration, Ret% Refers to the percentage of reticulocytes, PLT_I Refers to the counting of platelets by the electrical impedance method channel, PLT_O Refers to the counting of platelets by the optical method channel; in the alarm result column are some alarm prompts, for example Eosinophilia Indicates eosinophilia, Anemia indicates anemia, PLT Clump Indicates platelet aggregation, Macrocytosis Indicates macrocytic erythrocytes, Atypical Lympho Indicates atypical lymphocytes, Lipid Particles represent lipid particles, Lymphocytosis Indicates an increase in lymphocytes, Leukocytosis Indicates an increase in white blood cells, Microcytosis Indicates microcytic red blood cells, Immature Gran represent immature granulocytes, Band Cell Suspected Indicates suspected rod cells, Low MCHC Alert Indicates that the average corpuscular hemoglobin concentration is low alarm.

Some embodiments of the present application disclose a blood analysis device for animals. Please refer to the picture 3 , the animal blood analysis device of some embodiments includes a blood sample supply unit 10 , Reagent Supply Department 20 , Response Department 30 , Measurement Department 40 ,processor 50 and animal measurement mode selection section 60 .

In some specific embodiments, the blood sample supply unit 10 For the supply of blood samples; reagent supply 20 It is used to supply reagents, such as hemolytic agents, fluorescent agents and / Or diluent, etc.; Reaction Department 30 It is used to provide a reaction place for samples and reagents to prepare samples formed by the reaction of samples and reagents; the determination part 40 It is used to detect the prepared sample, or to detect the sample to obtain detection data or measurement signals; the processor 50 It is used to analyze the measurement signal to obtain the analysis result of the blood, and to invent the processor in some embodiments 50 including but not limited to CPU ( Central Processing Unit , CPU ), micro control unit (Micro Controller Unit , MCU) , Field Programmable Gate Array ( Field-Programmable Gate Array , FPGA ) and digital signal processing ( DSP ) and other devices used to interpret computer instructions and process data in computer software. In some embodiments, the processor 50 It is used to execute each computer application program in the non-transitory computer-readable storage medium, so that the animal blood analysis device executes a corresponding detection process.

Each component will be described in detail below.

In some embodiments, the blood sample supply unit 10 It may include a sample needle, and the sample needle performs two-dimensional or three-dimensional movement in space through a two-dimensional or three-dimensional driving mechanism, so that the sample needle can move to absorb the sample in the container (such as a sample tube) carrying the sample, and then move to It is used to provide a reaction place for the tested sample and reagent, such as the reaction part 30 , to the Response Department 30 Join the sample.

In some embodiments, the reagent supply 20 Can include areas for carrying reagent containers and connecting the reagent containers to the reaction section 30 Connected reagent liquid path, the reagent is added from the reagent container to the reaction part through the reagent liquid path 30 middle. In some embodiments, the reagent supply 20 It can also include a reagent needle, the reagent needle can move two-dimensionally or three-dimensionally in space through a two-dimensional or three-dimensional drive mechanism, so that the reagent needle can move to absorb the reagent in the reagent container, and then move to the test sample and reagents provide a reaction site such as a reaction section 30 , to the Response Department 30 Add reagents.

Response department 30 Supply unit for receiving blood samples 10 Blood samples and reagent supply provided by 20 Reagents provided to prepare test specimens. In some embodiments, the reaction part 30 One or more reaction cells may be included. Response department 30 A processing site or reaction site for providing samples and reagents. Different detection items can share the same reaction pool; different detection items can also use different reaction pools.

By treating the sample with a reagent, a sample to be tested can be obtained. In some embodiments, the reagent includes one or more of a hemolytic agent, a fluorescent agent, and a diluent. A hemolytic agent is a reagent capable of lysing red blood cells in blood samples and body fluid samples, specifically, it can be any one of cationic surfactants, nonionic surfactants, anionic surfactants, and amphiphilic surfactants one or a combination of several. The fluorescent agent is used to stain blood cells, and the specific type is selected according to the detection item.

For some examples, please refer to Fig. 4 , Measurement Department 40 including at least the optical detection unit 60 , as explained below.

In some embodiments, the optical detection unit 60 The sample can be measured by the principle of laser scattering. The principle is: the laser is irradiated on the cells, and the light signals generated after the cells are irradiated, such as scattered light and / Or fluorescence, to classify and count cells, etc.-of course, in some embodiments, if the cells are not treated with fluorescent reagents, then naturally no fluorescence can be collected. Next to the measurement department 40 Optical detection unit in 60 Be explained.

Please refer to the picture 5 , Optical Detection Section 60 can include light source 61 , mobile chamber 62 and optical detector 69 . flow chamber 62 and response department 30 Connected, for the cells of the sample to be tested to pass one by one; the light source 61 for irradiation through the flow chamber 62 cells, optical detector 69 For getting cells through the flow chamber 62 light signal. picture 6 for the optical detection unit 60 A specific example of an optical detector 69 Can include lens stacks to collect forward scattered light 63 , a photodetector used to convert the collected forward scattered light from an optical signal to an electrical signal 64 , a lens set for collecting side scattered light and side fluorescence 65 , dichroic mirror 66 , a photodetector used to convert the collected side scattered light from an optical signal to an electrical signal 67 , a photodetector used to convert the collected lateral fluorescence from an optical signal to an electrical signal 68 ; where the dichroic mirror 66 For light splitting, the mixed side scattered light and side fluorescence are divided into two paths, one is side scattered light and the other is side fluorescence. It should be noted that the optical signal herein may refer to an optical signal, or may refer to an electrical signal converted from an optical signal, and they are substantially consistent in characterizing the information contained in the cell detection result.

May wish to use the picture 6 The optical detection section shown 60 structure as an example to illustrate the optical detection section 60 How to specifically obtain the optical signal of the sample to be tested.

flow chamber 62 The cells for the samples to be tested are passed one by one. e.g. in the reaction section 30 After the red blood cells in the sample are dissolved by some reagents such as hemolytic agents, or further dyed by fluorescent agents, the sheath flow technology is used to make the cells in the prepared test sample flow from the flow chamber 62 queued up one after the other. in the picture Y The axis direction is the direction of cell movement in the sample to be tested. It should be noted that, in the figure Y The axis direction is the direction perpendicular to the paper surface. light source 61 for irradiation through the flow chamber 62 Cell. In some embodiments, the light source 61 For lasers, such as helium-neon lasers or semiconductor lasers. When the light source 61 The emitted light illuminates the flow chamber 62 When the cells in the cell will scatter to the surrounding. Therefore, when the cells in the prepared sample to be tested pass through the flow chamber one by one under the action of the sheath flow 62 when the light source 61 flow chamber 62 The cells illuminated, the light irradiated on the cells will scatter to the surroundings, and pass through the lens group 63 to collect forward scattered light - for example in the Z axis so that it reaches the photodetector 64 , so that the information processing department 70 available from the photodetector 64 Obtain the forward scattered light information of the cells; at the same time, pass through the lens group in the direction perpendicular to the light irradiating the cells 65 Collect side light - for example in the picture x axis direction, the collected side light passes through the dichroic mirror 66 Reflection and refraction occur, where the side scattered light in the side light passes through the dichroic mirror 66 reflection occurs, and then reaches the corresponding photodetector 67 , the side fluorescence in the side light also reaches the corresponding photodetector after being refracted or transmitted. 68 , so that the processor 50 available from the photodetector 67 Obtain the side scattered light information of the cell from the photodetector 68 Obtain the lateral fluorescence information of the cells. Please refer to the picture 7 , for the optical detection unit 60 another example. In order to make the light source 61 flow chamber 62 The light performance is better and can be used in light source 61 and flow chamber 62 collimating lens 61a ,light source 61 The emitted light is collimated by the lens 61a collimated and back through the flow cell 62 cells irradiated. In some cases, in order to make the collected fluorescence noise less (that is, there is no interference from other light), the photodetector can be 68 set a filter in front of the 66a , via a dichroic mirror 66 The side fluorescence after splitting is passed through a filter 66a before reaching the photodetector 68 . Some implementation examples, in the lens group 63 After collecting the forward scattered light, an aperture is introduced 63a to define the eventual arrival photodetector 64 The angle of the forward scattered light, for example, the forward scattered light is limited to low angle (or small angle) forward scattered light.

The white blood cells can be classified and counted by the laser light scattering method, and the above-mentioned optical detection part 60 Just one example. The scattered light produced by the cells irradiated by the laser beam is related to the cell size, the refractive index of the cell membrane and the internal structure of the cell. According to the scattered light signal, the distribution diagram of blood cell size and cell internal information can be obtained, which is called particle scatter diagram, classification scatter diagram, or scatter diagram for short.

Understandably, in this paper, the determination part 40 The assay signal obtained by detecting, in some embodiments, refers to the above optical signal.

In some embodiments, the animal measurement mode selection unit 60 Used to select one of various animal measurement modes as the current animal measurement mode. Various animal measurement modes, such as pig, horse, cow, dog, and cat, can be preset in the blood analysis device for animals. In some embodiments, the plurality of animal measurement modes includes at least a cat measurement mode and a dog measurement mode. The user can set or select a corresponding animal measurement mode for the blood sample through an input tool such as a keyboard or a mouse. example figure 8 As an example, the user can select the corresponding animal measurement mode from the blood sample through the mouse and other tools from the drop-down box, the number in the figure is 001-A , 002-B , 003-C The blood samples were set to cat measurement mode, cat measurement mode and dog measurement mode respectively.

In some embodiments, different animal measurement modes have their own analysis algorithms, that is, after the measurement signal of the blood sample is obtained, the processor 50 According to the set animal measurement mode of the blood sample, a corresponding analysis algorithm can be selected to analyze the measurement signal and obtain the analysis result.

In some embodiments, different animal measurement modes have respective analysis result range values, and the processor 50 The analysis result of the blood sample can be calibrated according to the range value of the analysis result corresponding to the animal measurement mode in which the blood sample is set, such as whether it is negative or positive, whether it is within a normal range value, or the like.

In some embodiments, the animal measurement mode has mode characteristic parameters, for example, the mode characteristic parameters include the particle distribution in the preset area of the particle scatter diagram generated by the measurement signal, and another example, the mode characteristic parameters include the final result such as the mean red blood cell volume result. In actual situations, R&D personnel can extract, select and set mode characteristic parameters according to the characteristics of the intermediate results or final results obtained by analyzing the blood samples of each animal from the measurement signals through experiments.

The solution proposed by some embodiments of the present invention can remind the user whether the type of the test sample (blood sample) or the animal measurement mode is wrong. In some embodiments of the present invention, based on the determination signal obtained from the detection of blood samples, relevant features (ie, the pattern feature parameters mentioned herein) are searched for as a basis for judgment and prompting. Let’s take a cat blood sample and a dog blood sample as an example, but those skilled in the art can understand that blood samples from animals other than cats and dogs can also be selected according to the selected mode characteristic parameters. Error message.

The characteristic basis (pattern characteristic parameters) of the judgment and prompt of the wrong animal type or the wrong selection of the animal measurement mode for the blood sample can be expressed as the result of the classification scatter diagram. example figure 9 and diagram 10 Shown are dog blood samples and cat blood samples measured in the correct animal measurement mode at the end of the animal blood analysis device, respectively, DIFF As a result of the classification scatter plot of the channel, it can be seen that there are obvious characteristic differences between the two - eosinophils in cat blood ( EOS ) particles appear in two groups (or the main group of eosinophil particles is located at the upper right of the monocyte particles and appears as a thin strip). When the dog blood sample is set to test in the cat measurement mode on the animal blood analysis device, as shown in the figure 11 As shown, its DIFF The classification scatter plot may happen to have no obvious classification errors, but when the cat blood sample is set to be tested in the dog measurement mode on the animal blood analysis device, as shown in 12 As shown, its DIFF The classification scatterplot has obvious misclassification phenomenon - the particles that should belong to eosinophils are misclassified into other types, resulting in a low count of eosinophils. Therefore, this feature can be used as an important basis for distinguishing animal types, and this feature can be used as a mode characteristic parameter, or at least as a basis for judging whether the cat blood sample is set to other animal measurement modes. It should be noted that, Fig. 9 to map 12 middle, FL means fluorescence, SS is side scattered light.

Pattern feature parameters can also be final parameter results. For example, based on clinical statistics, the mean corpuscular volume ( MCV ) results are generally not less than 50fL (femtoliters), while the mean corpuscular volume of cat blood samples ( MCV ) results are generally not higher than 55fL ; Therefore, based on this feature, it can also judge whether the animal type is wrong, and then give a prompt to the user.

The above examples illustrate the two characteristics commonly used in judging the sample type (animal type) of cat blood and dog blood, and there are many other characteristics. The comprehensive use of various features can make the prompt result more accurate.

The above are some illustrations of the animal measurement mode.

Based on the research and invention of the inventors, some embodiments of the present invention can determine whether the blood sample is set or selected in the wrong animal measurement mode, for example, the blood sample of a cat is wrongly set to the dog measurement mode, which will be described in detail below.

After the blood sample is set in the animal measurement mode, the blood sample is measured by the blood analysis device for the animal, the measurement part can obtain the measurement signal, and the processor obtains the mode characteristic parameters of the blood sample in the currently selected animal measurement mode according to the measurement signal. value, and judge whether the current animal measurement mode is wrongly selected according to the value of the characteristic parameter of the mode.

It may be illustrated by taking the distribution of particles in a preset area whose mode characteristic parameter is a particle scatter diagram as an example. In some embodiments, the determination signal includes at least two kinds of light signals, such as side scattered light and fluorescence; the mode characteristic parameter includes the particle distribution in the preset area of the particle scatter diagram generated based on the above-mentioned at least two kinds of light signals; processing device 50 According to the measurement signal, the particle distribution of the blood sample in the above-mentioned preset area of the above-mentioned particle scatter diagram is obtained; the processor 50 Judging whether the particle distribution of the blood sample in the above-mentioned preset region of the particle scattergram conforms to the preset particle distribution of the currently selected animal measurement mode in the above-mentioned preset region of the particle scattergram; if not , the processor 50 It is judged that the current animal measurement mode is selected incorrectly, for example, the cat blood sample is selected as the dog measurement mode, for example, the dog blood sample is selected as the cat measurement mode. In some specific embodiments, the particle distribution in the preset area of the particle scattergram includes the number of particle clusters; the processor 50 Obtain the number of particle clusters of the blood sample in the preset area of the particle scatter diagram according to the measurement signal; the processor 50 Determine whether the number of particle clusters of the blood sample in the preset area of the particle scattergram is equal to the preset number of particle clusters in the preset area of the particle scattergram of the currently selected animal measurement mode; if not, then the processor 50 Judging that the current animal measurement mode selection is wrong, for example, when the blood sample is set to the cat measurement mode, the blood sample should be in the 10 middle EOS Region should have 2 particle clusters, if the measured signal of the blood sample is in the figure 10 middle EOS The region exhibits only 1 particle clusters, indicating that the selection of animal measurement mode for this blood sample is wrong.

Let us take the result that the model characteristic parameter is mean red blood cell volume as an example for illustration. In some embodiments, the processor 50 According to the measurement signal, the mean red blood cell volume result of the blood sample is obtained; the processor 50 Determine whether the mean red blood cell volume result of the blood sample is within the preset mean red blood cell volume result range of the currently selected animal measurement mode; if not, the processor 50 It is judged that the current animal measurement mode selection is wrong.

in the processor 50 When it is judged that the current animal measurement mode selection of the blood sample is wrong, the predetermined operation can be performed when the animal measurement mode selection is wrong, such as giving the user a corresponding prompt message, prompting "the animal type of the current sample may be wrong" or "the animal measurement mode of the current sample may be incorrect". mode setting error", etc.; it can also be expressed as MCV And other mode characteristic parameters are specially marked to assist in prompting.

In some embodiments, the processor 50 The predetermined operation when the selection of the animal measurement mode is wrong includes at least one of the following:

( 1 )processor 50 Generate an error prompt for animal mode selection;

( 2 )processor 50 Judging the animal measurement mode matched by the current blood sample according to the characteristic parameters, and generating corresponding prompts;

( 3 )processor 50 The animal measurement mode matched by the current blood sample is judged according to the characteristic parameters, and the current blood sample is retested according to the animal measurement mode.

The above are some descriptions of the blood analysis apparatus for animals. Some embodiments also disclose a blood analysis method, which will be described in detail below.

Please refer to the picture 13 , the blood analysis method of some embodiments comprises the following steps:

step 110 : Get the current animal measurement mode; where the blood analysis method has multiple animal measurement modes, and the animal measurement mode has mode characteristic parameters. In some embodiments, the plurality of animal measurement modes includes at least a cat measurement mode and a dog measurement mode.

step 120 : Sample preparation from blood samples and reagents. Understandably, the steps 110 The current animal measurement mode acquired in is aimed at the animal measurement mode in which the blood sample to be analyzed is set.

step 130 : Measure the sample to obtain the measurement signal.

step 140 : According to the measurement signal, the value of the mode characteristic parameter of the blood sample in the current animal measurement mode is obtained, and according to the value of the mode characteristic parameter of the blood sample in the current animal measurement mode, it is judged whether the current animal measurement mode is selected incorrectly.

It may be illustrated by taking the distribution of particles in a preset area whose mode characteristic parameter is a particle scatter diagram as an example. In some embodiments, the determination signal includes at least two kinds of light signals, such as side scattered light and fluorescence; the mode characteristic parameter includes the particle distribution in the preset area of the particle scatter diagram generated based on the above-mentioned at least two kinds of light signals; step 140 According to the measurement signal, the particle distribution of the blood sample in the above-mentioned preset area of the above-mentioned particle scatter diagram is obtained; step 140 Judging whether the particle distribution of the blood sample in the above-mentioned preset region of the particle scattergram conforms to the preset particle distribution of the currently selected animal measurement mode in the above-mentioned preset region of the particle scattergram; if not , then the step 140 It is judged that the current animal measurement mode is selected incorrectly, for example, the cat blood sample is selected as the dog measurement mode, for example, the dog blood sample is selected as the cat measurement mode. In some specific embodiments, the particle distribution in the preset area of the above-mentioned particle scattergram includes the number of particle clusters; step 140 According to the determination signal, the number of particle clusters in the preset area of the above-mentioned particle scatter diagram of the blood sample is obtained; step 140 Determine whether the number of particle clusters of the blood sample in the preset area of the particle scattergram is equal to the preset number of particle clusters in the preset area of the particle scattergram of the currently selected animal measurement mode; if not, Then step 140 Judging that the current animal measurement mode selection is wrong, for example, when the blood sample is set to the cat measurement mode, the blood sample should be in the 10 middle EOS Region should have 2 particle clusters, if the measured signal of the blood sample is in the figure 10 middle EOS The region exhibits only 1 particle clusters, indicating that the selection of animal measurement mode for this blood sample is incorrect.

Let us take the result that the model characteristic parameter is mean red blood cell volume as an example for illustration. In some embodiments, the steps 140 Obtain the mean red blood cell volume result of the blood sample according to the determination signal; step 140 Determine whether the mean red blood cell volume result of the blood sample is within the preset mean red blood cell volume result range of the currently selected animal measurement mode; if not, then step 140 It is judged that the current animal measurement mode selection is wrong.

step 150 : When it is judged that the current selection of the animal measurement mode is wrong, perform the predetermined operation when the selection of the animal measurement mode is wrong. In some embodiments, the steps 150 The predetermined operation when the selection of the animal measurement mode is wrong includes at least one of the following:

( 1 ) to generate a prompt that the animal model is selected incorrectly;

( 2 ) Judging the animal measurement mode matched by the current blood sample according to the characteristic parameters, and generating a corresponding prompt;

( 3 ) According to the characteristic parameters, the animal measurement mode matched by the current blood sample is judged, and the current blood sample is re-inspected according to the animal measurement mode.

Some embodiments of the present invention provide a method for prompting the user to test sample type errors, the significance of which is to prompt the user to set the wrong sample type during the test, so that the user can make a decision to re-test, so as to obtain the real test results of the sample and ensure the accuracy of the parameter results. Accuracy, and finally make the correct clinical diagnosis.

This document is described with reference to various exemplary embodiments. However, those skilled in the art will recognize that changes and modifications can be made to the exemplary embodiments without departing from the scope herein. For example, the various operational steps, as well as the components used to perform the operational steps, may be implemented in different ways depending on the particular application or considering any number of cost functions associated with the operation of the system (e.g., one or more steps may be deleted, modified or incorporated into other steps).

In the above embodiments, all or part of them may be implemented by software, hardware, firmware or any combination thereof. In addition, the principles herein may be embodied in a computer program product on a computer-readable storage medium having computer-readable program code preloaded thereon, as understood by those skilled in the art. Any tangible, non-transitory computer-readable storage medium may be used, including magnetic storage devices (hard disks, floppy disks, etc.), optical storage devices ( cd to ROM , DVD , Blu Ray disk, etc.), flash memory and / or something like that. These computer program instructions can be loaded into a general purpose computer, special purpose computer or other programmable data processing apparatus to form a machine, so that these instructions executed on the computer or other programmable data processing apparatus can generate an apparatus for realizing specified functions. These computer program instructions may also be stored in a computer-readable memory which can instruct a computer or other programmable data processing device to operate in a particular manner such that the instructions stored in the computer-readable memory form a Manufactures, including implementing devices for implementing specified functions. Computer program instructions can also be loaded on a computer or other programmable data processing device, thereby performing a series of operational steps on the computer or other programmable device to produce a computer-implemented process, so that the computer or other programmable device Instructions may provide steps for performing specified functions.

While the principles herein have been shown in various embodiments, many modifications in structure, arrangement, proportions, elements, materials and components, particularly suited to particular circumstances and operational requirements may be made without departing from the principles and scope of this disclosure use. The above modifications and other changes or amendments are intended to be included within the scope of this document.

The foregoing detailed description has been described with reference to various embodiments. However, those skilled in the art will recognize that various modifications and changes can be made without departing from the scope of the present disclosure. Accordingly, the disclosure is to be considered in an illustrative rather than a restrictive sense, and all such modifications are intended to be embraced within its scope. Also, advantages, other advantages and solutions to problems have been described above with respect to various embodiments. However, neither benefits, advantages, solutions to problems, nor any elements that lead to these, or make the solutions more definite, should be construed as critical, required, or necessary. As used herein, the term "comprises" and any other variants thereof are non-exclusive, such that a process, method, article, or apparatus that includes a list of elements includes not only those elements, but also elements not expressly listed or not part of the process. , method, system, article or other element of a device. Furthermore, as used herein, the term "coupled" and any other variations thereof refer to physical, electrical, magnetic, optical, communicative, functional, and / or any other connection.

Those skilled in the art will recognize that many changes may be made to the details of the above-described embodiments without departing from the underlying principles of the invention. Accordingly, the scope of the invention should be determined from the following claims .

Claims (12)

1. A blood analysis device for animals, characterized in that it comprises:

   A blood sample supply part, used for supplying blood samples;

   a reagent supply part, used for supplying reagents;

   a reaction part, configured to receive the blood sample provided by the blood sample supply part and the reagent provided by the reagent supply part to prepare a sample;

   a measurement unit, configured to measure the sample to obtain a measurement signal;

   The animal measurement mode selection part is used to select one of various animal measurement modes as the current animal measurement mode;

   a processor, configured to analyze the measurement signal to obtain blood analysis results;

   in:

   The animal measurement mode has a mode characteristic parameter; the processor is also used to obtain the value of the mode characteristic parameter of the blood sample in the currently selected animal measurement mode according to the measurement signal, and according to the value of the mode characteristic parameter Judging whether the current animal measurement mode is wrongly selected; when the processor judges that the current animal measurement mode is wrongly selected, perform a predetermined operation when the animal measurement mode is wrongly selected.
2. The blood analysis device for animals according to claim 1, wherein the measurement signal includes at least two kinds of light signals; the pattern characteristic parameter includes a prediction of particle scatter diagram generated based on the at least two kinds of light signals. Particle distribution in the set area;

   The processor obtains the particle distribution of the blood sample in the preset area of the particle scattergram according to the measurement signal;

   The processor judges whether the particle distribution of the blood sample in the particle scattergram in the preset area conforms to the currently selected animal measurement mode in the particle scattergram in the preset area. Preset particle distribution;

   If not, the processor judges that the current animal measurement mode selection is wrong.
3. The blood analysis device for animals according to claim 2, wherein the particle distribution in the preset area of the particle scatter diagram includes the number of particle clusters;

   The processor obtains the number of particle clusters of the blood sample in a preset area of the particle scatter diagram according to the measurement signal;

   The processor judges whether the number of particle clusters of the blood sample in the preset area of the particle scattergram is equal to the preset particle number of the currently selected animal measurement mode in the preset area of the particle scattergram number of groups;

   If not, the processor judges that the current animal measurement mode selection is wrong.
4. The animal blood analysis device according to claim 2 or 3, wherein the at least two kinds of light signals include side scattered light and fluorescence.
5. The blood analysis device for animals according to claim 1, wherein the mode characteristic parameters include mean red blood cell volume results;

   The processor obtains the mean corpuscular volume result of the blood sample according to the measurement signal;

   The processor judges whether the mean red blood cell volume result of the blood sample is within the preset mean red blood cell volume result range of the currently selected animal measurement mode;

   If not, the processor judges that the current animal measurement mode selection is wrong.
6. The blood analysis device for animals according to claim 1, wherein the predetermined operation performed by the processor when the selection of the animal measurement mode is wrong includes at least one of the following:

   The processor generates a prompt that the animal model is selected incorrectly;

   The processor also judges the animal measurement mode matched by the current blood sample according to the characteristic parameters, and generates a corresponding prompt;

   The processor also judges the animal measurement mode matched by the current blood sample according to the characteristic parameters, and retests the current blood sample according to the animal measurement mode.
7. The blood analysis device for animals according to claim 1, 2 or 6, wherein the multiple animal measurement modes include at least a cat measurement mode and a dog measurement mode.
8. A blood analysis method, characterized in that, comprising:

   Obtain the current animal measurement mode; wherein the blood analysis method has multiple animal measurement modes, and the animal measurement mode has mode characteristic parameters;

   Sample preparation from blood samples and reagents;

   assaying the sample to obtain an assay signal;

   Obtain the value of the mode characteristic parameter of the blood sample in the current animal measurement mode according to the measurement signal, and judge whether the current animal measurement mode is selected according to the value of the mode characteristic parameter of the blood sample in the current animal measurement mode mistake;

   When it is judged that the current animal measurement mode is wrongly selected, a predetermined operation is performed when the animal measurement mode is wrongly selected.
9. The blood analysis method according to claim 8, characterized in that, the measurement signal includes at least two kinds of light signals; and the mode characteristic parameter includes a preset region of a particle scatter diagram generated based on the at least two kinds of light signals The distribution of particles;

   The judging whether the current animal measurement mode is wrongly selected includes:

   Obtaining the particle distribution of the blood sample in the preset area of the particle scattergram according to the measurement signal;

   judging whether the particle distribution of the blood sample in the particle scattergram in the preset area conforms to the preset particle distribution in the particle scattergram in the preset area of the currently selected animal measurement mode Condition;

   If not, it is judged that the current animal measurement mode is wrongly selected.
10. The blood analysis method according to claim 8, wherein the pattern characteristic parameters include mean red blood cell volume results;

    The judging whether the current animal measurement mode is wrongly selected includes:

    Obtaining the mean corpuscular volume result of the blood sample according to the determination signal;

    judging whether the mean corpuscular volume result of the blood sample is within the preset mean corpuscular volume result range of the currently selected animal measurement mode;

    If not, it is judged that the current animal measurement mode selection is wrong.
11. The blood analysis method according to claim 8, wherein the predetermined operation includes at least one of the following:

    Generate an error prompt for animal mode selection;

    Judging the animal measurement mode matched by the current blood sample according to the characteristic parameters, and generating a corresponding prompt;

    The animal measurement mode matched by the current blood sample is judged according to the characteristic parameters, and the current blood sample is retested according to the animal measurement mode.
12. The blood analysis method according to any one of claims 8 to 11, characterized in that the multiple animal measurement modes include at least a cat measurement mode and a dog measurement mode.