CN1945325A - Sample analyzer and sample analyzing method - Google Patents

Sample analyzer and sample analyzing method Download PDF

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Publication number
CN1945325A
CN1945325A CN 200610141059 CN200610141059A CN1945325A CN 1945325 A CN1945325 A CN 1945325A CN 200610141059 CN200610141059 CN 200610141059 CN 200610141059 A CN200610141059 A CN 200610141059A CN 1945325 A CN1945325 A CN 1945325A
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animal species
analysis
sample
determination data
analysis condition
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CN 200610141059
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CN1945325B (en
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平山英树
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Sysmex Corp
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Sysmex Corp
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Priority claimed from JP2005290251A external-priority patent/JP4669368B2/en
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Abstract

A sample analyzer comprising: a measurement section for measuring a sample of an animal; a memory for storing a measurement data by the measurement section; an analysis section for analyzing the measurement data stored on the memory in accordance with a first analysis condition corresponding to a previous setting of a species of an animal; and a selection receiver for receiving a selection of a species of an animal, which is different from the species of the previous setting, after analyzing the measurement data by the analysis section; wherein the analysis section analyzes the measurement data stored on the memory in accordance with a second analysis condition corresponding to the selection of a species of an animal when the selection receiver receives the selection of a species of an animal, is disclosed. A sample analyzing method is also disclosed.

Description

Sample analyzer and sample analyzing method
Technical field:
The present invention relates to the sample analyzing method that is used to analyze the sample analyzer of various animal samples and is used for various animals.
Background technology:
Nowadays, Biosamples such as frequent blood to animal, urine are analyzed at pets hospital and livestock products testing field etc.Do can use when this Biosample is analyzed such as U.S. Patent application announce the 2005/5053521st and U.S. Patent application announce disclosed analytical equipment on the 2003/0070498th.Therefore this type of pets hospital and livestock products testing field require this analytical equipment can analyze multiple animal often in the face of multiple animal.So the disclosed analytical equipment of above-mentioned patent documentation can be selected different animal species, Biosample is analyzed with the analysis condition that is fit to selected animal species.
The proterties of every kind of its blood of animal and Biosamples such as urine all has remarkable different.For this reason, must under the analysis condition that is fit to analyzed animal species, analyze Biosample, otherwise can not get correct analysis result.Yet in a single day above-mentioned analytical equipment selects animal species to begin to analyze the back just can not change animal species again, just in case the animal species that selected mistake just must be analyzed with Biosample again.Particularly toy etc. can't be gathered Biosamples such as blood, urine in a large number, and repeatedly the sampling meeting causes great burden to biology, and therefore, Biosample is very valuable, and it is extremely important to control unnecessary consumption.Moreover analyzing must be from sampling again, very time-consuming.
Summary of the invention:
The present invention aims to provide a kind of sample analyzer to solve above-mentioned technical barrier.
Another purpose of the present invention is to provide a kind of sample analyzing method.
Above-mentioned purpose of the present invention is achieved by the following technical solution.
The invention provides a kind of sample analyzer, comprising:
Measure the mensuration part of animal sample;
Be used for the memory of data that storing measurement is partly measured;
Be used for analyzing the analysis part of the determination data that deposits storer in, this analysis is carried out under first analysis condition that is fit to default animal species; And
Be used to accept to presetting the selection receptacle of animal species change, this change is carried out after being chosen in above-mentioned analysis part assay determination data;
When selecting receptacle to accept change to animal species, analysis part will be analyzed the determination data that exists in the storer under second analysis condition that is fit to selected animal species.
Described sample analyzer also comprises: the preliminary election receptacle is used to accept the selection in advance to animal species, with as default animal species.Be used to show display: the analysis result that under first analysis condition, draws with lower page; And the animal species of selecting in advance.Wherein, described display also shows the image of the animal species of selecting in advance.Wherein, described selection receptacle is controlled the button or the image of described display, the animal species of analyzing in order to the change analysis part, and analysis result is presented on the display.Wherein, described determination part branch measures this sample after the preliminary election receptacle has been accepted selection in advance to animal species.
Described sample analyzer also comprises: the analysis condition receptacle, and the analysis condition that is used to accept animal species and is fit to this animal species, described analysis condition will be used to first and second analysis conditions.The result's of display analysis partial analysis display wherein, selects receptacle to accept the selection of animal species as a result the time at this display display analysis.
Wherein, first analysis condition comprises a threshold value at least, so that with described determination data classification; And second analysis condition comprise a threshold value that is different from first analysis condition at least so that the described determination data of classification.Wherein, by analyzing by the determination data of the above-mentioned first analysis condition threshold value or the second analysis condition threshold value classification, described analysis part obtains some predetermined sample compositions.Wherein, described sample is a blood; Described predetermined composition comprises blood cell.
A kind of sample analyzer provided by the present invention comprises:
Be used to measure the mensuration part of animal sample;
The memory of data that part is measured is measured in memory;
Select receptacle, be used to accept to measure part and measure behind the sample selection animal species; And
Analysis part is used under the analysis condition of selected animal species that be fit to select receptacle to accept analyzing stored at the determination data of storer.
Described sample analyzer also comprises: the preliminary election receptacle is used for accepting predefined animal species before described mensuration part is measured this sample; Wherein, analysis part, assay determination data under the analysis condition of the preliminary election animal species that is fit to above-mentioned preliminary election receptacle acceptance.
Also comprise: measure the instruction accepting device, be used for behind the animal species that the preliminary election receptacle is accepted to select in advance, accepting the instruction that the determination part branch begins to measure.The analysis condition receptacle is used to accept animal species and is fit to the analysis condition of this animal species, and this analysis condition is with the situation of performing an analysis.
Described sample analyzer also comprises: display is used for the analysis result that display analysis is partly obtained; Wherein, when this display shows described analysis result, select receptacle to accept animal species and select.Wherein, animal species is selected from dog, cat, ox, horse, pig, sheep, goat, deer, mouse, rabbit.Wherein analysis condition comprises a threshold value at least, with the determination data classification.
The invention provides a kind of sample analyzing method, comprising:
Measure the method for animal sample;
Under first analysis condition that is fit to default animal species, analyze the determination data of this sample;
After analyzing described determination data, accept change to default animal species; And,
Under second analysis condition that is fit to the change animal species, this determination data is analyzed again.
Acceptance is to the selection in advance of animal species, as default animal species.
Wherein, described analytical procedure comprises:
With at least one threshold value that is fit to default animal species with the determination data classification, and
Analyze the determination data of the threshold value classification of step by analysis; And
Wherein, analytical procedure comprises again:
With this determination data classification, this threshold value is different from the threshold value that is used for analytical procedure with at least one threshold value, and is fit to selected animal species; And
Analysis is used to the determination data of the threshold value classification of analytical procedure again.
Description of drawings:
Fig. 1 is the structural outline oblique view of the biological sample analyzer of embodiment of the present invention.
Fig. 2 is controller architecture figure.
Fig. 3 and Fig. 4 are the analysis process figure of the biological sample analyzer of embodiment of the present invention.
Fig. 5 is homepage figure.
Fig. 6 is for selecting the page of tested animal species dialogue.
Fig. 7 is the page in measuring.
Fig. 8 is the white blood cell size-grade distribution exemplary plot in a kind of animal.
Fig. 9 is the white blood cell size-grade distribution exemplary plot in other animal species.
Figure 10 is the analysis result display page.
Figure 11 is other pages of the analysis result page.
Figure 12 is for confirming the page of manual analyzing.
Figure 13 is the manual analyzing page.
Figure 14 is a menu page.
Figure 15 is for selecting an example of animal species first page.
Figure 16 is for selecting animal species second page.
Figure 17 is for setting the page of animal species title.
Figure 18 judges the first unusual page for setting.
Figure 19 is for setting the compensating value page.
Figure 20 is for setting first page of classification thresholds.
Embodiment:
The preferred embodiments of the invention are described below with reference to accompanying drawings.
First of the present invention provides a kind of sample analyzer, and it comprises: the mensuration part that is used to measure the animal sample; Be used to store the storer of this determinator gained determination data; The analysis part of the determination data of analyzing stored in storer under the analysis condition that is adapted to default animal species; Accept the selective reception device to default animal species change after analysis part assay determination data: when the selection of selecting receiver acceptance to animal species, this analysis portion branch is the determination data of analyzing stored in storer under the second condition that is fit to selected animal species.
Second portion of the present invention provides a kind of sample analyzer, and it comprises: the mensuration part that is used to measure the animal sample; Be used to store the storer of this determinator gained determination data; Being used for this mensuration part measures and accepts selection receptacle that animal species is selected behind the sample; And the analysis part that is used for analyzing stored device determination data under the analysis condition that the animal species that is fit to select receptacle to accept is selected.
Third part of the present invention provides a kind of sample analyzing method, and it comprises: the method for measuring the animal sample; Under first analysis condition that is fit to default animal species, analyze the method for the determination data of this sample; After analyzing this determination data, accept method to default animal species change; And the method for under second analysis condition that is fit to selected animal species, determination data being analyzed again.
Fig. 1 is the structural outline oblique view of the biological sample analyzer of embodiment of the present invention.Biological sample analyzer 1 is to the red blood cell of various animals such as dog, cat, ox, horse and the blood count device of lencocyte count.Biological sample analyzer 1 can be analyzed with the pattern that adapts to various animals, such as the dog analytical model of analysis dog blood, the cat analytical model of analysis cat blood etc.
As shown in Figure 1, biological sample analyzer 1 is placed panel 4, button 5, controller 9, power supply 10, printer 11 and is measured mechanism 12 by casing 2, display 3, a corpse or other object for laboratory examination and chemical testing.Casing 2 is for being the casing of rectangular parallelepiped basically, these casing 2 built-in displays 3, controller 9, power supply 10, printer 11 and mensuration mechanism 12.Display 3 is a touch screen LCD, is assemblied in the positive top of casing 2.This display 3 is display message not only, also accepts user's input.There is a vacancy display 3 belows of casing 2, and this part vacancy is placed panel 4 by the corpse or other object for laboratory examination and chemical testing of door shape and filled.A corpse or other object for laboratory examination and chemical testing is placed panel 4 lower ends and is contained on the casing 2 by a transverse axis R, and a corpse or other object for laboratory examination and chemical testing is placed panel 4 can (arrow A direction among the figure) upset forward of this axle center.This corpse or other object for laboratory examination and chemical testing is placed panel 4 tops and is disposed button 5, and a corpse or other object for laboratory examination and chemical testing is placed panel 4 and button 5 mutual interlocks.The user touches the button and 5 can remove a corpse or other object for laboratory examination and chemical testing and place interlocks between panel 4 and the button 5, and the corpse or other object for laboratory examination and chemical testing that overturns is forward placed panel 4.The corpse or other object for laboratory examination and chemical testing that the user opens to pusher is placed panel 4 can make a corpse or other object for laboratory examination and chemical testing place panel 4 and button 5 interlock once again, and casing subject placement panel 4 again blocks, and gets back to closed state.
The back that a corpse or other object for laboratory examination and chemical testing is placed panel 4 is a corpse or other object for laboratory examination and chemical testing placer 6.Opening above the corpse or other object for laboratory examination and chemical testing placer 6, the physical container that a corpse or other object for laboratory examination and chemical testing (Biosample) is housed can be put into its inside from this opening part.Corpse or other object for laboratory examination and chemical testing placer 6 is placed panel 4 upsets with a corpse or other object for laboratory examination and chemical testing, so the user can be put into physical container in the corpse or other object for laboratory examination and chemical testing placer 6.After placing physical container, the user places panel 4 to a pusher corpse or other object for laboratory examination and chemical testing makes corpse or other object for laboratory examination and chemical testing placer 6 get back to off-position shown in Figure 1, can measure a corpse or other object for laboratory examination and chemical testing.
Measure mechanism 12 corpse or other object for laboratory examination and chemical testing processor 7 and fluid control 8 are arranged.This corpse or other object for laboratory examination and chemical testing processor 7 has moving mechanism 16, detecting device 17 and the mixed cabin 18 of suction.Inhale moving mechanism 16 and be used for drawing a corpse or other object for laboratory examination and chemical testing from the physical container that is placed on corpse or other object for laboratory examination and chemical testing placer 6, inject detecting device 17 and mixed cabin 18, it is made up of the motor of volumetric pipette and mobile volumetric pipette etc.Fluid control 8 is connected with the reagent container 13 that reagent is housed by flexible pipe 15, transfers the pump of reagent and the motor of driving pump etc. in addition.Under the control of this fluid control 8, a corpse or other object for laboratory examination and chemical testing and reagent are injected into or discharge detecting device 17 and mixed cabin 18.Mixed cabin 18 is used to mix a corpse or other object for laboratory examination and chemical testing and reagent, and preparation is measured and used sample, and the sample that comes out in these mixed cabin 18 preparations offers detecting device 17.The known resistance-type detection method of detecting device 17 usefulness detects blood cell, the electronic signal of blood cell feature in the output expression corpse or other object for laboratory examination and chemical testing.Meanwhile, detecting device 17 also detects the turbidity (absorbance) of a corpse or other object for laboratory examination and chemical testing with known optical detection, the electronic signal of output expression turbidity.Particularly, the electronic signal of white blood cell, red blood cell, haemoglobin and blood platelet feature that corpse or other object for laboratory examination and chemical testing are contained is represented in these detecting device 17 outputs.This output signal is delivered to controller 9, and controller 9 is handled these signals, and the data that obtain expression institute's each particle of examine (blood cell) size (volume) and the data of representing corpse or other object for laboratory examination and chemical testing turbidity (absorbance) are as determination data.This controller 9 is not only controlled each several part running, also Calculation results.Power supply 10 will become direct current from the alternating current of commercial ac power source, supply with the motor of controller 9 and each several part etc.Printer 11 is accepted the instruction of controller 9, the printing analysis result.
Describe the structure of controller 9 below in detail.Fig. 2 is the structural drawing of controller 9.Controller 9 has CPU20, storer 21, driving circuit 22 and signal processing circuit 23.CPU20 can carry out the program that leaves storer 21 in, and the CPU20 executive routine makes biological sample analyzer 1 carry out the aftermentioned operation.Storer 21 is by such as ROM and flash memory formations such as (registered trademarks) such as RAM such as SRAM, DRAM, ROM (read-only memory), EEPROM, program pre-deposits, the data and storing measurement data and the analysis result that can also download, stored routine produce in carrying out.Storer 21 comprises district 21a and two districts of 21b, district.
District 21a store to be responsible for overall control biological sample analyzer 1 executive routine, handle control fluid control 8 and inhale moving mechanism 16 motor, carry out the measurement operation program of measurement operation control and the electronic signal of detecting device 17 outputs carried out signal Processing, analyzed the routine analyzer that the gained determination data is obtained analysis result.District 21b is the zone of these program sharings.This district 21b can store the analysis result data D that shows biological sample analyzer 1 analysis result.Each corpse or other object for laboratory examination and chemical testing of this analysis result data has, and the data (such as the data of 20 corpse or other object for laboratory examination and chemical testing) of certain corpse or other object for laboratory examination and chemical testing are by distinguishing 21b from new to old sequential storage.Analysis result data D comprises the electronic signal that detecting device 17 is detected again and carries out the determination data D1 of signal Processing gained and display analysis process analysis result's analysis result data D2.
Driving circuit 22 is accepted the instruction of measurement operation program and is handled control motor and solenoid valve operating mechanism and displays 3 such as (not having diagram).The electronic signal that 23 pairs of detecting devices 17 of signal processing circuit draw is carried out certain signal Processing such as denoising, A/D conversion process, pulse height detection processing, the determination data D1 of output digital data.Represent the characteristic of sample at this gained determination data D1,, be stored among the district 21b of above-mentioned storer 21 for obtaining analyzing the intermediate data before the data D2.
Operation with regard to the biological sample analyzer 1 of embodiment of the present invention describes below.Fig. 3 and Fig. 4 are the operational flowchart of the biological sample analyzer 1 of embodiment of the present invention.The user at first starts biological sample analyzer 1.Start back controller 9 allows homepage be presented at (step S1) on the display 3 at once.Fig. 5 is a homepage.There are unit state viewing area 41, paper feed button 42, corpse or other object for laboratory examination and chemical testing viewing area 43, animal species viewing area 44, animal species to select visual 45a~45d, selector button 46, analysis result button 47, shutdown button 48 and start button 50 etc. on the homepage 31.At this moment, a corpse or other object for laboratory examination and chemical testing is not put into biological sample analyzer 1 as yet, so unit state viewing area 41 is shown as " getting ready ".The state that can begin is measured in this expression of " getting ready ".When this homepage occurring, user's pressing button 5 is placed panel 4 to a front opening corpse or other object for laboratory examination and chemical testing, and a corpse or other object for laboratory examination and chemical testing is placed into corpse or other object for laboratory examination and chemical testing placer 6, pushes away a corpse or other object for laboratory examination and chemical testing again and places panel 4 and turn over, and makes itself and button 5 interlocks, soon the corpse or other object for laboratory examination and chemical testing biological sample analyzer 1 of packing into.
In second step, controller 9 is accepted user's a corpse or other object for laboratory examination and chemical testing number input (at step S2, pressing Yes).Following the carrying out of input of this corpse or other object for laboratory examination and chemical testing number: the user is with the corpse or other object for laboratory examination and chemical testing viewing area 1 of Fingertip touch homepage 31, and soft keyboard appears in display 3.The user can import a corpse or other object for laboratory examination and chemical testing number with the Fingertip touch soft key.In the 3rd step, controller 9 is accepted tested animal species and is selected, is that operator scheme is set (at step S3, pressing Yes).It is dog that the animal species of homepage 31 is selected visual 45a, and 45b is that cat, 45c are that ox, 45d are horse, and the page demonstrates the animal species that each image distributes.Though be decorated with each animal species in Fig. 5 image, be not limited thereto, such as also showing the literal of representing animal species.If in these four images tested animal species is arranged, just with the image of this animal species of Fingertip touch, specify this animal species with this is measurand (tested animal species) to the user.At this moment, the image of only being appointed as tested animal species shows that for colored other images are white and black displays, showing the different of the image that is designated as tested animal species and other images, the user be easy to definite which be designated as tested animal species.
If specify these four kinds of animals other animal species in addition, the user will carry out following operation: at first, the user uses Fingertip touch selector button 46.Selector button 46 1 is selected, tested animal species just occurs and selects dialog box.Fig. 6 is the page that tested animal species is selected dialog box.Tested animal species selects dialog box 51 to arrange a plurality of animal species selections with button 51a~51c, also shows skip button 52 and X button 53.Button 51a~51c can need to distribute arbitrarily animal species with the user, and shows the animal species title that is assigned with.In the example shown in Figure 6, the user does not distribute, and is shown as " OTHER1 ", " OTHER2 ", " OTHER3 " on these buttons 51a~51c.If select one of these buttons 51a~51c, it is tested animal species that controller 9 will be set the animal species that selected button gives.That is, in this dialog box 51, the user needs only the desirable animal species button of Fingertip touch, and this kind animal promptly is designated as tested animal species.Tested animal species selects dialog box 51 to be made up of multipage, and button 52 controllers 9 of selecting to skip will switch to demonstration another page.Therefore, if show in the page or leaf there is not the animal species button of wanting, the user can switch to other pages with demonstration with the Fingertip touch button 52 that skips.Select 53 dialog boxes 51 of X button to close.
At this, handle to describe with regard to the animal species of button 51a~51c correspondence and corresponding to the acceptance of the analysis condition of this animal species.
Figure 15 selects an example of first page for animal species.This page is to occur by the setting button 159 of selecting menu page 133 shown in Figure 14 to show.As shown in figure 15, animal species is selected first page 134 to be provided with unit state viewing area 41, paper feed button 42 and is returned homepage button 55, in addition, correspond respectively to 10 the animal species button 160a~160j of various animals and the button 161a that skips in addition, 161b.Animal species button 160a is appointed as dog, shows " Dog ".Equally, animal species button 160b, 160c, 160d are designated as cat, ox, horse respectively, show " Cat ", " Cow ", " Horse " respectively.Animal species button 160e~160j can specify animal species arbitrarily by the user, and shows appointed animal species.Example among Figure 15 does not carry out user's appointment, is shown as " OTHER1 ", " OTHER2 ", " OTHER3 " on these buttons 160e~160j ...Select first page 134 at this animal species, if the user with the Fingertip touch button 161a that skips, 161b shows that then animal species selects second page.Figure 16 is animal species and selects second page.As shown in the figure, animal species selects second page 135 to remove unit state viewing area 41, paper feed button 42, return homepage button 55 and the button 161a that skips, and outside the 161b, also has 7 animal species button 160k~160q and visual designated button 162.At animal species button 160k~160q, the user can specify animal species arbitrarily, and shows appointed animal species title.In the example of Figure 16, the user does not specify, the last demonstration of these buttons 160k~160q " OTHER7 ", " OTHER8 ", " OTHER9 " ...In case select to skip button 161a, 161b, above-mentioned animal species select first page 134 to switch demonstration.
The user selects first page 134 and animal species to select second page 135 will change setting to the animal species analysis condition at animal species, just select to think the corresponding animal species button of the animal species 160a~160q of change setting, change animal species and select the setting of visual 45a~45d will select visual designated button 162.
At this, the analysis condition change will be described in detail in detail handle.If the analysis condition of change dog, cat, ox, horse, the user uses Fingertip touch animal species button 160a, 160b, and 160c, 160d sets first page so the unusual judgement of the animal species corresponding with selected knob occurs.The explanation of setting first page about unusual judgement is seen below and is stated.On the other hand, the user will set other animal species analysis conditions, some with among Fingertip touch animal species button 160e~160q just, and the animal species title setting page corresponding with selected button can appear in display 3 like this.Figure 17 sets the page for the animal species title, and as shown in the figure, the animal species title is set the page 136 and selected first page 134 the same with animal species, unit state viewing area 41, paper feed button 42 is arranged, return homepage button 55 and the button 161a that skips, 161b.Also have input text viewing area 163, soft keyboard 164 and save button 165 in addition.The user can set the page 136 in this animal species title, with soft keyboard 164 input texts (animal species title).Such as the analysis condition that will set rabbit, the user is input " Rabbit " just, and so the text display of input is in input text viewing area 163.Preserve the input content, the user uses Fingertip touch save button 165, and like this, controller 9 will be attached to input text corresponding animal species button, deposits storer 21 in.In addition, the analysis condition page of setting usefulness also have unusual judge set first page, unusual judge set second page, unusual judge set the 3rd page, unusual judge set the 4th page, judge that setting the 5th page, compensating value sets that the page, classification thresholds are set first page, classification thresholds is set second page unusually.As shown in the figure, the button 161a that skips shows arrow left, and the button 161b that skips shows arrow to the right.Whenever the user with the Fingertip touch button 161a that skips, 161b, the demonstration of display 3 will switch to other analysis conditions and set and use the page.The user can press (selection) the button 161a that skips, and 161b sets and uses the page until desirable analysis condition occurring.
Figure 18 is unusual setting first page of judging.As shown in the figure, it is the same with the animal species title setting page 136 that first page 137 is set in unusual judgement, unit state viewing area 41, paper feed button 42 arranged, return homepage button 55, button 161a skips, 161b and save button 165 also have animal species viewing area 166 and unusual judgement setting value viewing area 167 in addition.Set the unusual judgment value that first page 137 can be set white blood cell concentration (WBC), red blood cell concentration (RBC), hemoglobin concentration (HGB), blood cell volume (HCT) and mean corpuscular volume (MCV) (MCV) in this unusual judgement.Judge that unusual setting second page can set mean corpuscular hemoglobin (MCH), the unusual judgment value of mean corpuscular hemoglobin (MCHC) and び PC (PLT), judge that unusual setting the 3rd page can set microleucocyte hematocrit (W-SCR), medium-sized white blood cell hematocrit (W-MCR), and the unusual judgment value of large-scale white blood cell hematocrit (W-LCR), judge that unusual setting the 4th page can set microleucocyte concentration (W-SCC), the unusual judgment value of medium-sized white blood cell concentration (W-MCC) and large-scale white blood cell concentration (W-LCC) judges that unusual setting the 5th page can set red blood cell dispersion of distribution SD (RDW-SD), red blood cell dispersion of distribution CV (RDW-CV), MPW (PDW), average platelet volume (MPV), the unusual judgment value of large-scale blood platelet ratio (P-LCR).Unusually judge setting with the upper and lower bound of setting normal assay value.Be assay value not between this upper and lower bound just be judged as unusual, the display abnormality sign.The user shows the zone of thinking change setting with Fingertip touch, selects this zone.In case setting value is regional selected, soft keyboard 168 has shown, and the user can import new setting value with soft keyboard 168.The setting value of input is presented at institute's favored area, and the expression setting value changes.This soft keyboard 168 can only input digit, the not soft key of configuration letter.After so change unusual judgement setting value, the user just selects save button 165 if store this setting value, and controller 9 is understood in view of the above and to be deposited this setting value in storer 21 as the unusual judgement setting value of object animal species.
Figure 19 sets the page for compensating value.As shown in the figure, compensating value is set the page 138 and is judged that with unusual setting first page 137 is the same, unit state viewing area 41, paper feed button 42 arranged, return homepage button 55, button 161a skips, 161b, save button 165 and animal species viewing area 166, in addition, also has compensating value viewing area 169.Set the compensating value that the page 138 can be set hemoglobin concentration (HGB) and blood cell volume (HCT) in this compensating value.The user shows the zone of wanting the compensating value that changes with Fingertip touch, selects this zone.In case the compensating value zone is selected, soft keyboard 168 occurs, and the user can be by the new compensating value of this soft keyboard input.The compensating value of input is presented at institute's favored area, and the expression compensating value changes.After so change compensating value, the user just selects save button 165 if store this compensating value, and controller 9 is understood in view of the above and to be deposited this compensating value in storer 21 as the compensating value of object animal species.
Figure 20 sets first page for classification thresholds.As shown in the figure, classification thresholds is set first page 139 and is judged that with unusual setting first page 137 is the same, unit state viewing area 41, paper feed button 42 arranged, return homepage button 55, button 161a skips, 161b, save button 165 and animal species viewing area 166, in addition, also has classification thresholds setting value viewing area 170.Set first page 139 in this classification thresholds and can set leukocytic hierarchical level LD, T1, T2.Set second page in classification thresholds and can set erythrocytic hierarchical level and hematoblastic hierarchical level.The user shows the zone of wanting the setting value that changes with Fingertip touch, selects this zone.In case the setting value zone is selected, soft keyboard (not having diagram) occurs, and the user can be by the new setting value of this soft keyboard input.The setting value of input is presented at institute's favored area, and the expression setting value changes.After so change the hierarchical level setting, the user just selects save button 165 if store this setting value, and controller 9 is understood in view of the above and to be deposited this setting value in storer 21 as the hierarchical level of object animal species.So the animal species of storage hierarchical level will carry out analyzing and processing with this hierarchical level.Dog, cat, ox, four kinds of animals of horse (or dog, cat, three kinds of animals of ox) as mentioned above, the low ebb position of retrieval size-grade distribution is a hierarchical level with this low ebb position in the certain limit.In addition, the animal species that can set in the present embodiment is not limited, such as being pig, sheep, mouse and rabbit etc.
After the setting of having changed analysis condition like this, the user returns homepage button 55 with Fingertip touch, and homepage 31 is returned in indication.
Below with reference to the flow process of Fig. 3, turn back to explanation to the operation of biological sample analyzer 1.The instruction (selecting Yes) that controller 9 acceptance begin to measure at step S4.If user will indicate begins to measure, just with Fingertip touch start button 50, so selected start button 50 after, controller 9 can begin mensuration work, and in display 3, show measure in the page (step S5).In addition, even select start button 50 at the animal species etc. accepted of step S3 before selecting, mensuration work can not begin yet.Fig. 7 is the page in measuring, as shown in Figure 7, the page 32 and homepage 31 are the same in the mensuration unit state viewing area 41, a paper feed button 42, also has corpse or other object for laboratory examination and chemical testing viewing area 43a, animal species viewing area 44a in addition, returns homepage button 55, analysis result viewing area 56, information display area 57 and measure work progress situation viewing area 58.The page 32 in this measures, unit state viewing area 41 shows " in the action " literal.The user in case in this measures the page 32 select to return homepage button 55, the demonstration of display 3 switches to homepage 31.As shown in the figure, the information of " can extract a corpse or other object for laboratory examination and chemical testing " appearred in information display area 57 after a corpse or other object for laboratory examination and chemical testing of measuring was drawn from physical container.At this moment, the user can open a corpse or other object for laboratory examination and chemical testing and place panel 4 extraction corpse or other object for laboratory examination and chemical testing.Measuring work progress situation viewing area 58 is strip parts of page lower end, and its horizontal total length is for measuring required time, that is, left end is for measuring the zero hour, and right-hand member is for measuring the finish time, and the portrait of dog moves from left to right with measuring the work progress situation.The page in mensuration when Fig. 7 is the dog analytical model, the portrait of position of representing during the cat analytical model to make progress becomes cat, and the demonstration meeting is measured animal species at difference and is changed.
So begin to measure, then detecting device is measured the blood cell in the corpse or other object for laboratory examination and chemical testing, and its determination data D1 deposits the district 21b (step S6) of storer 21 in.This determination data of controller 9 usefulness D1 carries out analyzing and processing (step S7) to a corpse or other object for laboratory examination and chemical testing.Carry out under the analysis condition of the various animals of adaptation that this analyzing and processing is set in step S3.
Describe with regard to the analyzing and processing that 1 pair of corpse or other object for laboratory examination and chemical testing of biological sample analyzer carries out at this.In measuring mechanism's 12 mensuration white blood cells, use the sample that hemolytic agent is blended in the preparation of a blood corpse or other object for laboratory examination and chemical testing.The electronic signal of detecting device 17 outputs converts the pulse signal that particle size is shown as pulse to, by this electronic signal being carried out the determination data D1 that signal Processing obtains representing each particle size, therefore can utilize this determination data D1 to make particle size distribution figure.Fig. 8 is the white blood cell size-grade distribution illustration figure of a kind of animal (such as dog), and Fig. 9 is the white blood cell size-grade distribution illustration figure of other animal species (such as rabbit).As shown in the figure, the different white blood cell size-grade distribution of animal species are obviously different.This is because white blood cell size (granularity) is different different because of animal species.In addition, in white blood cell is measured, destroy red blood cell, eliminate erythrocytic influence and measure by in a corpse or other object for laboratory examination and chemical testing, adding hemolytic agent.The erythrocytic cell membrane that sustains damage because of the hemolytic agent that adds remains in the sample determined with white blood cell.In addition, also there are kinds such as lymph corpuscle, monocyte, acidophilia ball, basophilla ball, Neutrophils in the white blood cell, the particle size of each kind is different, therefore, in the analysing leucocyte that biological sample analyzer 1 is done, according to particle size classification (classification), such as: be equivalent to the large-scale white blood cell of Neutrophils, be equivalent to monocyte, the medium-sized white blood cell of acidophilia ball and basophilla ball, be equivalent to lymphocytic microleucocyte and red blood cell ghost (residual red blood cell film).In the example of Fig. 8 and Fig. 9, distinguish red blood cell ghost and white blood cell, distinguish microleucocyte and medium-sized white blood cell, distinguish medium-sized white blood cell and large-scale white blood cell according to the 3rd hierarchical level T2 according to the second hierarchical level T1 according to the first hierarchical level LD.These hierarchical levels are according to animal species and difference, have only suitably to set these hierarchical levels according to tested animal species and could correctly analyze.Thinner, even these hierarchical levels are also different because of corpse or other object for laboratory examination and chemical testing difference with a kind of animal, therefore, as Fig. 8 and shown in Figure 9, set the scope (dotting among the figure) of dividing hierarchical level according to various animals earlier, retrieve the low ebb position of size-grade distribution again in this scope, the low ebb position that retrieves promptly can be used as hierarchical level.At this moment, must suitably set the range of search of hierarchical level according to animal species, otherwise correctly classification.For above-mentioned reasons, biological sample analyzer 1 has been set analysis condition according to animal species in advance, and tested animal species is certain, can analyze under the analysis condition of this animal species.
When analyzing and processing finishes, controller 9 can deposit income analysis data D2 in the district 21b (step S8) of storer 21, allow printer 11 that analysis result is printed to (step S9) on the paper, show homepage 31 (step S10) at display 3 once more, wait for mensuration next time.Because analysis result is printed machine 11 and prints on the paper, the user can be easy to confirm analysis result.If the user need not to analyze (selecting No at step S11) once more with other kinds animal, want to continue the words (step S12 selects No) implementing to measure, a next corpse or other object for laboratory examination and chemical testing can be put into biological sample analyzer 1 and order to begin to measure.So show that automatically switching to homepage 31 makes the user needn't show the operation of homepage 31 when the next specimen analyzing of beginning, but a plurality of corpse or other object for laboratory examination and chemical testing of continuous high-efficient ground analysis.
On the other hand, because the situation of establishing tested animal species and analyzing also can appear missing in user's input error.If resemble above-mentioned a plurality of corpse or other object for laboratory examination and chemical testing of continuous analysis because can comprise multiple animal in a plurality of corpse or other object for laboratory examination and chemical testing, so the problem that the tested animal species of easier in this case generation mistake is established.Such as, after the analysis of having made a dog corpse or other object for laboratory examination and chemical testing continuously, do the analysis of a cat corpse or other object for laboratory examination and chemical testing again, switch to the cat analytical model after just must analyzing for several times continuously, but be easy to forget pattern conversion this moment with the dog analytical model.In case the tested animal species mistake of such generation, the user at first selects analysis result button 47, orders its display analysis result.(step S11 selects Yes) made display 3 display analysis results page (step S13) when controller 9 was accepted the instruction of display analysis results page.
Figure 10 is the analysis result page.The analysis result page 33 has unit state viewing area 41, paper feed button 42, corpse or other object for laboratory examination and chemical testing viewing area 43a, animal species viewing area 44a, represents the diagram 44b of animal species, returns homepage button 55, analysis result viewing area 56, in addition, also have manual analyzing button 59, minute viewing area 60, manual analyzing sign viewing area 61, lettering button 62, HC output button 63 and the button 64 that skips.So, because analysis result and animal species show that simultaneously the user is easy to confirm selected animal species, can reduce and let slip the possibility that animal species is selected mistake.In addition, though in the present embodiment, the two shows animal species viewing area 44a and diagram 44b, also can only show a wherein side.
At this analysis result page 33, if show " can not measure " literal on the unit state viewing area 41, then expression can not begin to measure.Minute viewing area 60 literal show measures date and time.Analysis result viewing area 56 shows white blood cell concentration (WBC), red blood cell concentration (RBC), hemoglobin concentration (HGB), hematocrit (HCT) and the PC of really obtaining as Fen Xi Knot (PLT).In addition, analyse in the Knot fruit, can show unusual sign 56a by the while indicator gauge for the value that exceeds by the default normal range of every kind of animal at branch.Its text color of value and the background counter-rotating of being changed by the aftermentioned manual analyzing show.By showing this analysis result page 33, the user can confirm analysis result on display 3, can reaffirm before manual analyzing whether the setting of tested animal species is wrong, and is very convenient.The user selects lettering button 62, and this analysis result will be printed machine 11 and print on the paper, and the user selects HC load button 63, and then this analysis result sends the outside host microcomputer (not having diagram) that is connected to biological sample analyzer 1 to.Narrate about 61 back, manual analyzing sign viewing area.
The analysis result page has multipage, and the user can assign the instruction of skipping by the button 64 of selecting to skip.Whenever just switch one page by (selection) button 64 that once skips.Therefore, the user is as long as occur until the page or leaf of wanting by the button 64 that skips for several times.Figure 11 is the displayed map of other pages of the analysis result page.Figure 11 has shown expression white blood cell labor result's the page.This page demonstrates ratio and the concentration of each white blood cell composition with respect to its composition sum in analysis result viewing area 56.With these numerical datas, also show particle size distribution figure, the particle size distribution figure below shows hierarchical level (LD, T1, setting value T2).In this detailed, but as other pages or leaves, the page or leaf that shows whole analysis results in addition, it is display analysis result's main project not only: white blood cell concentration (WBC), red blood cell concentration (RBC), hemoglobin concentration (HGB), hematocrit (HCT) and PC (PLT), also show red blood cell average volume (MCV), the average content of hemoglobin of red blood cell (MCH) and average red blood cell hemoglobin concentration (MCHC), show red blood cell labor result's the page and demonstration blood platelet labor result's the page in addition.
The user is manual analyzing if desired, just selects manual analyzing button 59, gives an order to show the manual analyzing enforcement affirmation page.Controller 9 accepts to show the instruction (step S14 selects Yes) of the manual analyzing enforcement affirmation page, and then display 3 switches to manual analyzing and implements to confirm the page (step S15).
Figure 12 implements to confirm the page for manual analyzing.Manual analyzing implements to confirm that the page 34 is the same with the analysis result page 33, unit state viewing area 41, paper feed button 42, corpse or other object for laboratory examination and chemical testing viewing area 43a, animal species viewing area 44a are arranged, return homepage button 55, analysis result viewing area 56, minute viewing area 60 and manual analyzing sign viewing area 61, also have animal species change button 65, WBC change button 66, RBC change button 67, PLT change button 68 and cancel button 69 in addition.Implement to confirm that in this manual analyzing the analysis result viewing area 56 in the page 34 is basic identical with the demonstration of the analysis result page 33, so explanation is omitted.Animal species change button 65 is to be used for changing the button that tested animal species is set, WBC change button 66 is to be used for the button that change is set white blood cell analysis condition (hierarchical level), RBC change button 67 is to be used for the button that change is set red blood cell analysis condition (hierarchical level), and PLT change button 68 is to be used for the button that change is set blood platelet analysis condition (hierarchical level).The user will change to tested animal species or to white blood cell, red blood cell and blood platelet analysis condition and set, as long as select the corresponding button to get final product change setting.If the user does not analyze again, the optional button 69 that disappears (step S16 assigns the cancellation instruction) of selecting returns step S13, display analysis results page 33.On the other hand, in case selector button 65~68 one of them (step S16 assigns " showing the manual analyzing page " instruction), controller 9 will make display 3 show the variable setting value and the manual analyzing page of analyzing once more (step S17).
Figure 13 is the manual analyzing page.The manual analyzing page 35 is the same with the analysis result page 33, unit state viewing area 41, paper feed button 42, corpse or other object for laboratory examination and chemical testing viewing area 43a, animal species viewing area 44a are arranged, return homepage button 55, analysis result viewing area 56, minute viewing area 60, manual analyzing sign viewing area 61 and the button 64 that skips, also have manual analyzing project choice button 70, change button 71a in addition, 71b and analysis button 72 again.The same with the analysis result page 33, this manual analyzing page 35 also has multipage (all analysis result pages or leaves, white blood cell labor result page, red blood cell labor result page and blood platelet labor result page), and user's button of can selecting to skip switches the page.The demonstration of the analysis result viewing area 56 in this manual analyzing page 35 is also roughly the same with the analysis result page 33, so related description is omitted.The user can be with 35 changes of this manual analyzing page to tested animal species or to the setting of white blood cell, red blood cell and blood platelet analysis condition, and implements to analyze again.
With tested animal species of following step change and analysis condition setting value.Changing tested animal species can carry out at all pages or leaves of the manual analyzing page.Implement to confirm the page 34 selection animal species change buttons 65 in manual analyzing, then 44a left side in animal species viewing area shows meat ball image 73, represents variable setting to tested animal species.Change the selection that button 71a and 71b are used for animal species this moment.As shown in the figure, change button 71a shows arrow left, and change button 71b shows arrow to the right.Whenever the user with Fingertip touch change button 71a, the animal species title that shows among the 44a of animal species viewing area will be switched in certain sequence singly, represents that tested animal species is set to be changed.When the user with Fingertip touch change button 71b, then animal species switches by opposite order.The user with Fingertip touch change button 71a and 71b until showing desirable animal species title, promptly variable tested animal species.Tested animal species so changes, and then the corresponding analysis condition of its tested animal species is set thereupon.
On the other hand, the setting of analysing leucocyte condition can only be in the white blood cell labor result page change of the manual analyzing page, and the setting of red blood cell analysis condition can only can only be changed at blood platelet labor result page in the setting of red blood cell labor result page, blood platelet analysis condition.At this, describe though only change with regard to the setting of analysing leucocyte condition, the setting change of red blood cell and blood platelet analysis condition also can be carried out equally.The setting user who changes the analysing leucocyte condition will allow display 3 show the white blood cell labor result page of the manual analyzing page earlier.Implement to confirm the page 34 selection WBC change buttons 66 in manual analyzing, then meat ball image 73 appears in the setting value of hierarchical level left side, and expression can be changed the setting of hierarchical level.In original state, selection be LD, T1, the LD in three hierarchical levels of T2.At this moment, the user uses Fingertip touch manual analyzing project choice button 70, and then hierarchical level is pressed T1, T2, LD ... order switch.At this moment, change button 71a, 71b is used to change the hierarchical level setting value.Along with the user changes button 71a with Fingertip touch, selected hierarchical level setting value can be more and more littler, along with the user can be increasing with the selected hierarchical level setting value of Fingertip touch change button 71b.The user changes setting to analysis condition with Fingertip touch change button 71a and 71b, reaches desirable setting value until hierarchical level.
Controller 9 is accepted will wait for the enforcement instruction of analyzing again (step S19) to measuring the change (step S18 selects Yes) that animal species is set or analysis condition is set.Analyze again and implement to instruct and to select again analysis button 72 to assign by the user.If controller 9 is received the enforcement instruction of analysis again (step S19 selects Yes) meeting analysis (step S20) once more under the analysis condition that has changed that the user sends.This handles and uses the determination data D1 that is stored in storer 21 district 21b to analyze under the condition of new settings.Therefore, need not to inhale again and move corpse or other object for laboratory examination and chemical testing preparation sample, can prevent valuable corpse or other object for laboratory examination and chemical testing waste.Such as, even surplus in the physical container have a corpse or other object for laboratory examination and chemical testing, if but this corpse or other object for laboratory examination and chemical testing be used for having analyzed again, just can not carry out other analyses, carrying out other analyses if desired also needs to gather once more a corpse or other object for laboratory examination and chemical testing.And, if the not enough mensuration of the quantity of a last corpse or other object for laboratory examination and chemical testing is required in the physical container, just must sample once more.Particularly animal has a lot of toys not sample in a large number, causes very big burden can for this biology from the sampling on one's body of this toy once more.Therefore, a corpse or other object for laboratory examination and chemical testing is very valuable, controls it and is wasted in the Biosample analysis extremely important.Even do not begin to analyze once more from resampling in the present embodiment, also the determination data obtained of the analysis of utilizing is over analyzed once more, and the therefore used time is short, can save a large amount of man-hours.
In addition, if changing tested animal species analyzes again, manual analyzing sign viewing area 61 show labels [S] then, if the setting of change analysing leucocyte condition (hierarchical level) is analyzed again, then show label [W] is analyzed if change the setting of red blood cell analysis condition (hierarchical level), then show label [R] again, if the setting of change blood platelet analysis condition (hierarchical level) is analyzed again, then show label [P].
When analyzing and processing has again finished, accepts the user and returns the selection of homepage button 55 (step S21 selects Yes), controller 9 will show the page that determines whether to preserve again analysis result, accept user's instruction (step S22).At step S22, if receive the instruction (S22 selects Yes in step) of preserving again analysis result, controller 9 can deposit income analysis data D2 in storer 21 district 21b (step S23), and allows printer 11 that analysis result is printed on (step S24) on the paper, and controller 9 returns step S12.In addition, if receive the instruction (S22 selects No in step) of not preserving at step S22, then controller 9 directly returns step S12.
If the user wants to finish the analysis of 1 pair of corpse or other object for laboratory examination and chemical testing of biological sample analyzer, with Fingertip touch homepage 31 shutdown buttons 48.If biological sample analyzer 1 is then closed in the selection (S12 selects Yes in step) that controller 9 is accepted shutdown button 48.
For simple and brief, omitted explanation in the present embodiment, but in fact all can analyze once more at any time the analysis result data D that is kept at storer 21.
In addition, in the present embodiment, after having narrated the tested animal species of setting, from measuring the structure that being formulated into of sample obtained determination data D1 and implemented the continuous sequence of operations of analyzing and processing, but be not limited in this, such as its structure also can be not set tested animal species earlier, and obtains determination data D1 earlier, sets suitable animal species again and analyzes.
In the present embodiment, described structure is selected animal species earlier before accept measuring sign on, but is not limited in this, such as, also can preestablish default animal species, when not selecting animal species with this default animal species assay determination data D1.
In the present embodiment, biological sample analyzer 1 is the structure of analyzing blood particle, but is not limited in this, such as, also can be the device that carries out blood coagulation mensuration and immunoassay and urinalysis etc.

Claims (21)

1. sample analyzer comprises:
Measure the mensuration part of animal sample;
Be used for the memory of data that storing measurement is partly measured;
Be used for analyzing the analysis part of the determination data that deposits storer in, described analysis is carried out under first analysis condition that is fit to default animal species; And
Be used to accept to presetting the selection receptacle of animal species change, described change is carried out after being chosen in above-mentioned analysis part assay determination data;
It is characterized in that: when the change of selecting receptacle acceptance to animal species, analysis part is analyzed the determination data that exists in the storer under second analysis condition that is fit to selected animal species.
2. sample analyzer according to claim 1 also comprises: the preliminary election receptacle is used to accept the selection in advance to animal species, with as default animal species.
3. sample analyzer according to claim 2 wherein also comprises:
Be used to show display with lower page:
The analysis result that under first analysis condition, draws; And
The animal species of Xuan Zeing in advance.
4. sample analyzer according to claim 3, wherein said display also show the image of the animal species of selecting in advance.
5. sample analyzer according to claim 3, wherein said selection receptacle is controlled the button or the image of described display, the animal species of analyzing in order to the change analysis part, and analysis result is presented on the display.
6. sample analyzer according to claim 2, wherein said determination part branch measures this sample after the preliminary election receptacle is accepted selection in advance to animal species.
7. sample analyzer according to claim 1 wherein also comprises: the analysis condition receptacle, and the analysis condition that is used to accept animal species and is fit to this animal species, described analysis condition will be used to first and second analysis conditions.
8. sample analyzer according to claim 1 also comprises: the result's of display analysis partial analysis display, and wherein select receptacle to accept the selection of animal species as a result the time at this display display analysis.
9. sample analyzer according to claim 1, wherein first analysis condition comprises a threshold value at least, so that with described determination data classification; And second analysis condition comprise a threshold value that is different from first analysis condition at least so that the described determination data of classification.
10. sample analyzer according to claim 9, wherein, by analyzing by the determination data of the above-mentioned first analysis condition threshold value or the second analysis condition threshold value classification, described analysis part obtains some predetermined sample compositions.
11. sample analyzer according to claim 9, wherein said sample are blood, described predetermined composition comprises blood cell.
12. a sample analyzer comprises:
Be used to measure the mensuration part of animal sample;
The memory of data that part is measured is measured in memory;
Select receptacle, be used to accept to measure part and measure behind the sample selection animal species; And
Analysis part is used under the analysis condition of selected animal species that be fit to select receptacle to accept analyzing stored at the determination data of storer.
13. sample analyzer according to claim 12 also comprises:
The preliminary election receptacle is used for accepting predefined animal species before described mensuration part is measured this sample;
Wherein, analysis part, assay determination data under the analysis condition of the preliminary election animal species that is fit to above-mentioned preliminary election receptacle acceptance.
14. sample analyzer according to claim 13 also comprises: measure the instruction accepting device, be used for behind the animal species that the preliminary election receptacle is accepted to select in advance, accepting the instruction that the determination part branch begins to measure.
15. sample analyzer according to claim 12 also comprises:
The analysis condition receptacle is used to accept animal species and is fit to the analysis condition of this animal species, and this analysis condition is with the situation of performing an analysis.
16. sample analyzer according to claim 12 also comprises: display is used for the analysis result that display analysis is partly obtained; Wherein, when this display shows described analysis result, select receptacle to accept animal species and select.
17. sample analyzer according to claim 12, wherein animal species is selected from dog, cat, ox, horse, pig, sheep, goat, deer, mouse, rabbit.
18. sample analyzer according to claim 12, wherein analysis condition comprises a threshold value at least, with the determination data classification.
19. a sample analyzing method comprises:
Measure the method for animal sample;
Under first analysis condition that is fit to default animal species, analyze the determination data of this sample;
After analyzing described determination data, accept change to default animal species; And
Under second analysis condition that is fit to the change animal species, this determination data is analyzed again.
20., wherein also comprise the in advance selection of acceptance, as default animal species to animal species according to the described sample analyzing method of claim 19.
21. according to the described sample analyzing method of claim 19, wherein said analytical procedure comprises:
With at least one threshold value that is fit to default animal species with the determination data classification, and
Analyze the determination data of the threshold value classification of step by analysis; And
Wherein, analytical procedure comprises again:
With this determination data classification, this threshold value is different from the threshold value that is used for analytical procedure with at least one threshold value, and is fit to selected animal species; And
Analysis is used to the determination data of the threshold value classification of analytical procedure again.
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