WO2023037725A1 - 前処理装置 - Google Patents
前処理装置 Download PDFInfo
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- WO2023037725A1 WO2023037725A1 PCT/JP2022/026014 JP2022026014W WO2023037725A1 WO 2023037725 A1 WO2023037725 A1 WO 2023037725A1 JP 2022026014 W JP2022026014 W JP 2022026014W WO 2023037725 A1 WO2023037725 A1 WO 2023037725A1
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- Prior art keywords
- blade
- dispensing nozzle
- dispensing
- tip
- nozzle tip
- Prior art date
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- 238000007781 pre-processing Methods 0.000 title abstract 3
- 238000005520 cutting process Methods 0.000 claims abstract description 52
- 230000007246 mechanism Effects 0.000 claims abstract description 32
- 238000000034 method Methods 0.000 claims abstract description 12
- 230000008569 process Effects 0.000 claims abstract description 9
- 239000007788 liquid Substances 0.000 claims abstract description 5
- 238000007599 discharging Methods 0.000 claims abstract 2
- 238000009751 slip forming Methods 0.000 claims description 2
- 238000009825 accumulation Methods 0.000 abstract description 4
- 230000004308 accommodation Effects 0.000 abstract description 3
- 230000032258 transport Effects 0.000 description 49
- 238000012360 testing method Methods 0.000 description 12
- 239000002699 waste material Substances 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 2
- 235000017491 Bambusa tulda Nutrition 0.000 description 2
- 241001330002 Bambuseae Species 0.000 description 2
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 2
- 239000011425 bamboo Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/103—General features of the devices using disposable tips
Definitions
- the present invention relates to a pretreatment device.
- a pretreatment device such as a specimen pipetting device
- Specimen pipetting devices are installed in examination rooms of hospitals and testing institutions together with or as a part of automatic analyzers, and are used to collect blood, urine, and other specimens collected from subjects from primary specimen containers.
- Specimen pipetting devices are installed in examination rooms of hospitals and testing institutions together with or as a part of automatic analyzers, and are used to collect blood, urine, and other specimens collected from subjects from primary specimen containers.
- a dispensing head equipped with a consumable dispensing nozzle chip Aspirates the sample in the primary sample container and discharges it into the secondary sample container.
- the dispensing nozzle tip attached to the dispensing head is removed from the dispensing head by a tip remover and discarded in a disposal box provided in the dispensing device. At this time, two tip removers are placed above the box to dispose of the dispensing nozzle tips separately.
- Patent Literatures 1 and 2 disclose techniques related to the disposal of dispensing nozzle tips in such dispensing devices.
- Patent Document 1 discloses a method for storing pipette tips, which comprises (a) cutting at least a portion of a pipette tip; A method for storing pipette tips is disclosed, comprising the steps of: stacking cut pipette tips closer together; and (c) storing the cut pipette tips in a predetermined storage area.
- Patent Document 2 discloses a nozzle tip discarding device for dropping and discarding a nozzle tip extracted from a nozzle base, wherein the tip remover for removing the nozzle tip is arranged in parallel and opposite to each other below the tip remover for removing the nozzle tip.
- a nozzle tip comprising a pair of rotating rollers that rotate, wherein the nozzle tip is dropped into a gap between the pair of rotating rollers and crushed by the pressing force of the pair of rotating rollers.
- a disposal device is disclosed.
- JP 2008-039674 A Japanese Patent Application Laid-Open No. 2007-139470
- tip removers are placed at two locations above the box to disperse and dispose of the dispensing nozzle tips, thereby stacking the dispensing nozzle tips in the disposal box. are not concentrated in one place.
- the dispensing nozzle tips may pile up like a bamboo shoot. There is a problem that the dispensing nozzle tips are piled up to one point, and subsequent dispensing nozzle tips cannot be discarded.
- the present invention has been made in view of the above, and an object of the present invention is to provide a pretreatment device that can improve storage efficiency while suppressing the accumulation of discarded dispensing nozzle tips.
- the present application includes a plurality of means for solving the above problems.
- One example is a dispensing process in which a liquid sample stored in a sample container is aspirated and then discharged into another sample container for dispensing.
- a disposal box for discarding and a cutting mechanism for cutting the dispensing nozzle tip inserted into the removing portion for removing the dispensing nozzle tip from the dispensing nozzle from the longitudinal side are provided.
- FIG. 1 is a diagram schematically showing the overall configuration of a sample test automation system, which is an example of a pretreatment device;
- FIG. FIG. 4 is a top view schematically showing the internal configuration of the dispensing module;
- Fig. 2 is a vertical cross-sectional view schematically showing a dispensing tip disposal duct provided in the dispensing module along with related components. It is a top view which extracts and shows a chip
- FIG. 4 is a plan view schematically showing an extraction of a chip holding portion of the chip cutting mechanism;
- FIG. 4 is a plan view showing a state in which the dispensing nozzle tip is inserted into the cutting mechanism;
- FIG. 4 is a vertical cross-sectional view showing a state in which the dispensing nozzle tip is inserted into the cutting mechanism;
- FIG. 4 is a plan view showing a state in which the dispensing nozzle tip is cut by a cutting mechanism;
- FIG. 4 is a longitudinal sectional view showing a state in which the dispensing nozzle tip has been cut by a cutting mechanism;
- FIG. 10 is a diagram showing an overlapping state of dispensing nozzle tips in the prior art;
- FIG. 1 is a diagram schematically showing the overall configuration of a sample test automation system, which is an example of a pretreatment device according to the present embodiment.
- the sample test automation system 1 is composed of an input module 2, a centrifugal separation module 3, a capping module 4, a child test tube generation module 5, a dispensing module 6, a capping module 7, and a storage module 8.
- Each of the modules 2 to 8 has a transport device such as a belt conveyor capable of transporting a sample transport holder for loading and transporting a sample such as blood or urine. Transfer of sample transport holders to and from modules is possible.
- a transport device such as a belt conveyor capable of transporting a sample transport holder for loading and transporting a sample such as blood or urine. Transfer of sample transport holders to and from modules is possible.
- the input module 2 inputs, for example, a sample container containing a sample such as blood or urine collected from a patient (hereinafter referred to as a primary sample) into the sample test automation system 1.
- a parent sample is loaded into the loading module 2 by an operator.
- a case where three parent samples are introduced is exemplified.
- the three primary samples loaded into the input module 2 are sequentially loaded from the loading position by a moving mechanism such as a robot arm (not shown) onto sample transport holders arranged on the transport device, and transported to other modules by the transport device. be.
- the parent sample input to the input module 2 is transported together with the sample transport holder to the centrifugal separation module 3 or the unplugging module 4 according to the requested item of each analysis.
- the transported parent sample is centrifuged and transported to the child test tube generation module 5 and the capping module 4 together with the sample transport holder.
- the unplugging module 4 performs an unplugging process for unplugging the parent sample (sample container), and transports the sample transport holder to the secondary test tube generating module 5 .
- the parent sample transported to the child test tube generation module 5 is further transported to the dispensing module 6 by the transport device. Further, when the parent sample passes through the child test tube generation module 5, the child test tube generation module 5 generates a sample container (child container) to which information of the parent sample (for example, a barcode on which information is printed) is added. A sample container) is generated, mounted on a sample transport holder arranged on a transport device, and transported to the pipetting module 6 together with the sample transport holder.
- a sample container child container
- a sample container is generated, mounted on a sample transport holder arranged on a transport device, and transported to the pipetting module 6 together with the sample transport holder.
- the dispensing module 6 performs a dispensing process of dispensing the primary sample transported together with the sample transport holder by the transport device into the secondary sample containers transported together with the sample transport holder by the transport device in the same manner (detailed later).
- the capping module 7 performs capping processing for capping the primary specimen (specimen container) uncapped by the capping module 4 and the secondary specimen container created by the dispensing module 6, and each of the specimen transport holders is transported by the transport device to the storage module. Transfer to 8.
- the storage module 8 thermally stores the primary sample and secondary sample containers transported from the capping module 7 together with the sample transport holder.
- the secondary sample container stored in the storage module 8 is put into an analyzer or the like by an operator or by a transport device.
- FIG. 2 is a top view schematically showing the internal configuration of the dispensing module.
- FIG. 3 is a vertical cross-sectional view schematically showing the dispensing tip disposal duct provided in the dispensing module along with related components.
- the dispensing module 6 includes a primary sample transport line 11 that transports sample transport holders loaded with primary samples by a transport device (for example, a belt conveyor), and a transport device (for example, a belt conveyor) that transports sample transport holders loaded with secondary sample containers.
- a transport device for example, a belt conveyor
- a secondary sample transport line 12 for transporting by means of a belt conveyor and a transport line 13 for transporting a sample transport holder loaded with a parent sample (sample container) after dispensing processing and a sample transport holder loaded with a secondary sample container. have.
- a parent sample dispensing standby position 11a is set where a sample transport holder loaded with a parent sample (sample container) to be dispensed stands by during the dispensing process. Further, on the secondary sample transport line 12, a secondary sample dispensing standby position 12a is set where the secondary sample container corresponding to the primary sample waiting at the primary sample dispensing standby position 11a waits during the dispensing process.
- the dispensing module 6 has a plurality of modules that can integrally move between above the primary sample dispensing standby position 11 a of the primary sample transport line 11 and above the secondary sample dispensing standby position 12 a of the secondary sample transport line 12 . It has (for example, three) dispensing heads 17a, 17b, 17c. As also shown in FIG. 3, the dispensing heads 17a, 17b, and 17c have a cylindrical shape extending in the vertical direction, and their lower tips (lower ends) are attached by being inserted into the dispensing nozzle tip 101a. As possible, it has a tapered shape that narrows as it goes downward.
- a tip magazine 18 having a large number of insertion holes into which a plurality of dispensing nozzle tips 101a are inserted and held is located in front of the primary sample transport line 11 and the secondary sample transport line 12 in the dispensing module 6 (lower part in FIG. 2). are placed.
- the dispensing nozzle tip 101a has a cylindrical shape with one end (tip) narrowed. Dispensing nozzle tips 101a are bored in a plurality of insertion holes on the tip magazine 18, respectively, with their tips directed downward.
- Dispensing heads 17a, 17b, and 17c are mounted in front of the primary sample transport line 11 and secondary sample transport line 12 in the pipetting module 6 (lower in FIG. 2) and behind the chip magazine 18 (upper in FIG. 2).
- a tip remover 14 is provided for removing the dispensing nozzle tip 101a.
- the tip remover 14 has a plate shape arranged along the horizontal direction, and dispensing heads 17a, 17b, and 17c are provided so that the dispensing heads 17a, 17b, and 17c can be inserted horizontally.
- the same number of U-shaped notches (three in this case) are provided at the same intervals.
- the width of the U-shaped cutout portion of the tip remover 14 is wider than the joint portion of the dispensing heads 17a, 17b, and 17c with the dispensing nozzle tip 101a, and is wider than the upper end of the dispensing nozzle tip 101a (an end different from the tip). part). That is, while the dispensing heads 17a, 17b, and 17c to which the dispensing nozzle tip 101a is attached are horizontally inserted into the U-shaped notch of the tip remover 14, the dispensing heads 17a, 17b, and 17c are moved upward (Fig. 2), the dispensing nozzle tip 101a can be removed from the dispensing heads 17a, 17b, and 17c.
- a disposal duct 15 through which the dispensing nozzle chips 101a that are removed from the dispensing heads 17a, 17b, and 17c by the tip remover 14 and discarded pass. It is Further, below the disposal duct 15 (in the depth direction of the paper surface in FIG. 2), a disposal box 20 capable of accommodating a large number of used dispensing nozzle tips 101a that have passed through the disposal duct 15 is arranged.
- a cutting mechanism 25 is provided in the disposal duct 15 for cutting the dispensing nozzle tip 101a from the longitudinal side.
- the cutting mechanism 25 performs a cutting process when discarding the used dispensing nozzle tip 101a fixed to the dispensing heads 17a, 17b, and 17c. Details of the cutting mechanism 25 will be described below.
- FIG. 4 is a plan view schematically showing the tip cutting mechanism extracted.
- FIG. 5 is a plan view schematically showing an extraction of the chip holding portion of the chip cutting mechanism.
- the cutting mechanism 25 has at least as many cutting parts as the dispensing heads 17a, 17b, and 17c (here, three cutting parts, the same number as the dispensing heads 17a, 17b, and 17c).
- the cutting portion related to the dispensing head 17a will be described as a representative, and description of other cutting portions having the same configuration will be omitted.
- the cutting portion related to the dispensing head 17a has a first blade surface 311 and a second blade surface 312 that are continuously formed to contact the side surface of the dispensing nozzle tip 101a from different directions.
- the first blade 31 provided rotatably in the direction along the plane including the and the second blade surface 312, and the first blade surface 311 and the second blade surface 312 of the first blade 31 from different directions
- a second blade 32 having a blade surface 321 formed to abut on the side surface of the dispensing nozzle tip 101a and relatively fixed to the first blade 31 is provided.
- the first blade 31 is horizontally rotatably supported by a pin 35 fixed to the base 41 of the cutting mechanism 25 .
- the second blade 32 is fixed to the base 41 of the cutting mechanism 25 .
- the first Cutting is performed while holding the dispensing nozzle tip 101a within a range defined by the first blade surface 311 and the second blade surface 312 of the blade 31 and the blade surface 321 of the second blade 32 .
- Other cutting portions of the dispensing heads 17b and 17c have similar configurations.
- Each of the first blades 31 of the plurality of cutting portions is provided with an oblong hole portion 313, into which a pin 45 provided on a movable base 44 (connecting member) is inserted.
- a first blade 31 of the cutting part is connected.
- the movable base 44 is fixed to a timing belt 43 that transmits the power of a motor 42 that is an actuator. is rotated to simultaneously cut the plurality of dispensing nozzle tips 101a, 101b, 101c respectively arranged in the plurality of cutting units.
- a tip holding portion is provided below the first blade 31 and the second blade 32 of each cutting portion (on the back side of the paper surface in FIG. 4).
- the tip holding portion related to the dispensing head 17a will be described as a representative, and the explanation of other tip holding portions having the same configuration will be omitted.
- the tip holding portion related to the dispensing head 17a is rotatably provided coaxially with the first blade 31, and contacts the side surface of the dispensing nozzle tip 101a along the first blade surface 311 of the first blade 31.
- a first tip holding member 33 that is in contact with the first blade 31 and restrains relative rotation with respect to the first blade 31 from a position along the first blade surface 311 of the first blade 31 toward the dispensing nozzle tip 101a; It abuts on the side surface of the dispensing nozzle tip 101a from the direction facing the first tip holding member 33 (the same direction as the blade surface 321 of the second blade 32) and along the blade surface 321 of the second blade 32. and the first tip holding member 33 are biased toward the dispensing nozzle tip 101a side. and an elastic member 38 (for example, an elastic body such as a spring) that rotates the first tip holding member 33 with the second tip holding member 34 to hold the dispensing nozzle tip 101a between itself and the second tip holding member 34. .
- a first tip holding member 33 rotatably supported by a pin 35 is arranged below the first blade 31 .
- the first tip holding member 33 includes a rubber surface 331 with cushioning properties that abuts against the side surface of the dispensing nozzle tip 101a along the first blade surface 311 of the first blade 31, a protrusion 332 formed so as to stand up in the direction of the first blade 31 and suppressing the rotation of the first tip holding member 33 toward the dispensing nozzle tip 101a from the first blade surface 311 by coming into contact with the first blade 31; have.
- a second chip holding member 34 fixed to the base 41 like the second blade 32 is arranged below the second blade 32 .
- the second tip holding member 34 has a cushioning rubber surface 341 that contacts the side surface of the dispensing nozzle tip 101a along the blade surface 321 of the second blade 32 .
- Other tip holders associated with the dispensing heads 17b and 17c have similar configurations.
- dispensing nozzle tip 101a does not move away from the position between first blade 31 and second blade 32.
- FIG. For example, if the rotation axis (pin 35) is positioned outside the extension line of the blade surface 321 of the second blade 32, the dispensing nozzle tip 101a will move between the first blade 31 and the second blade during cutting. It moves in the direction of escape from the position between 32 (leftward in FIG. 4). Therefore, it is desirable that the rotation shaft (pin 35 ) be positioned between the first blade surface 311 of the first blade 31 and the blade surface 321 of the second blade 32 .
- the gap between the first blade surface 311 of the first blade 31 and the blade surface 322 of the second blade 32 is narrow, the dispensing nozzle tip 101a cannot be arranged, and if it is too wide, the amount of movement of the motor 42 increases. Therefore, the gap between the first blade surface 311 of the first blade 31 and the blade surface 322 of the second blade 32 is slightly wider than the outer diameter of the dispensing nozzle tip 101a to be cut (for example, tip diameter + 1 to 3 mm). ) is desirable.
- FIG. 6 is a plan view showing a state in which the dispensing nozzle tip is inserted into the cutting mechanism
- FIG. 7 is its vertical cross-sectional view
- 8 is a plan view showing a state in which the dispensing nozzle tip has been cut by the cutting mechanism
- FIG. 9 is a longitudinal sectional view thereof.
- the positions (hereinafter, shown in FIG. This position is called a chip disposal position).
- the vicinity of the longitudinal center of the dispensing nozzle tips 101a, 101b, 101c attached to the dispensing heads 17a, 17b, 17c is the first blade 31 of the cutting portion of the cutting mechanism 25 in the waste duct 15. and the second blade 32 .
- the cutting mechanism 25 starts operating, and the motor 42 rotates.
- a movable base 44 is moved via a timing belt 43 .
- the pin 45 of the movable base 44 rotates the first blade 31 clockwise around the pin 35 (that is, the first blade surface 311 and the second blade surface 311 of the first blade 31 and the second blade 31 rotates clockwise).
- the blade surface 312 rotates toward the blade surface 321 of the second blade 32).
- the first tip holding member 33 rotates in the same direction as the first blade 31 due to the biasing force of the elastic member 38 .
- the dispensing nozzle tip 101 a is sandwiched between the first blade surface 311 and the second blade surface 312 of the first blade 31 and the blade surface 321 of the second blade 32 .
- the first tip holding member 33 and the second tip holding member 34 grip the lower side of the cut portion (position of the first blade 31 and the second blade 32) of the dispensing nozzle tip 101a.
- the portion above the cut surface of the dispensing nozzle tip 101a is held in a state of being attached to the distal end of the dispensing head 17a, and the portion below the cut surface is held by the first tip holding member 33 and the second tip. It is held by the holding member 34 (chip holding portion).
- the motor 42 of the cutting mechanism 25 rotates in the opposite direction (clockwise), opening the first blade 31 and the first tip holding member 33, and cutting the first tip.
- the lower portion of the cut dispensing nozzle tip 101 a held by the tip holding member 33 and the second tip holding member 34 is released and discarded in the disposal box 20 .
- the dispensing head 17a is lifted, and the upper part of the cut dispensing nozzle tip 101a attached to the dispensing head 17a is caught in the U-shaped notch of the tip remover 14 and falls off the dispensing head 17a. , is discarded into the discard box 20 .
- FIG. 10 is a diagram showing an overlapping state of dispensing nozzle tips in the prior art.
- tip removers are placed at two locations above the box to disperse and dispose of the dispensing nozzle tips, thereby stacking the dispensing nozzle tips in the disposal box. are not concentrated in one place.
- the dispensing nozzle tips may pile up like a bamboo shoot as shown in FIG.
- the dispensing nozzle tips are easily piled up to the entrance of the disposal box, making it impossible to dispose of subsequent dispensing nozzle tips.
- dispensing nozzle tips 101a, 101b, and 101c are removed from dispensing heads 17a, 17b, and 17c (dispensing nozzles). Since the nozzle tips 101a, 101b, and 101c are configured to be cut from the longitudinal side, it is possible to improve the accommodation efficiency while suppressing the accumulation of the discarded dispensing nozzle tips 101a, 101b, and 101c.
- the primary sample and secondary sample containers transported to the dispensing module 6 are transported to the primary sample dispensing standby position 11a on the primary sample transport line 11 and the secondary sample dispensing standby position 12a on the secondary sample transport line 12, respectively. Once reached, it is secured with gripping members, not shown.
- the dispensing heads 17a, 17b, and 17c move above the tip magazine 18 and descend, and the tips of the dispensing heads 17a, 17b, and 17c are inserted into the dispensing nozzle tips 101a, 101b, and 101c of the tip magazine 18. It is worn by being.
- the dispensing heads 17a, 17b, and 17c rise, move above the parent sample dispensing standby position 11a, and descend.
- the dispensing nozzle tips 101a, 101b, and 101c come into contact with the liquid surface of the primary sample during descent, the sample in the primary sample container is sucked into the dispensing nozzle tips 101a, 101b, and 101c using pressure changes.
- the dispensing heads 17a, 17b, and 17c rise while the dispensing nozzle tips 101a, 101b, and 101c are filled with the primary sample, move above the secondary sample dispensing standby position 12a, and descend.
- the tips of the dispensing nozzle tips 101a, 101b, and 101c reach the tube bottom of the sub-sample container, they stop descending, and while rising, the samples filled in the dispensing nozzle tips 101a, 101b, and 101c use pressure changes. It is discharged into the secondary sample container (dispensing process).
- the primary sample and secondary sample containers that have been dispensed are transported by primary sample transport line 11 and secondary sample transport line 12 , and are transported out of dispensing module 6 via transport line 13 .
- the dispensing heads 17a, 17b, and 17c move above the waste duct 15 and descend.
- the dispensing heads 17a, 17b, 17c descend to the lower surface of the tip remover 14, the dispensing heads 17a, 17b, 17c move horizontally. Then, the dispensing nozzle tips 101a, 101b, and 101c are discarded by the cutting mechanism 25 at the tip discarding position (see FIG. 3).
- Movable base 45 Pin 101a... Dispensing nozzle tip 101b... Dispensing nozzle tip 101c... Dispensing nozzle tip 311... First blade surface 312... Second blade surface 313... Oval hole portion 321... Blade surface 322... Blade surface 331... Rubber surface 332... Protrusion, 341...Rubber surface
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Abstract
Description
図5に示すように、各切断部の第1の刃31及び第2の刃32の下側(図4中紙面奥側)には、チップ保持部が設けられている。以降、分注ヘッド17aに係るチップ保持部を代表して説明し、同様の構成を有する他のチップ保持部については説明を省略する。
また、回動軸(ピン35)が第1の刃31及び第2の刃に近いほど、モータ42の動作量を大きくする必要がある(可動ベース44の移動量が増える)が、モータ42のトルクは比較的小さくて済む。したがって、切断対象の分注ノズルチップ101aが硬い場合には、回動軸(ピン35)を第1の刃31及び第2の刃32に近づけることが望ましい。
なお、本発明は上記の実施の形態に限定されるものではなく、その要旨を逸脱しない範囲内の様々な変形例や組み合わせが含まれる。また、本発明は、上記の実施の形態で説明した全ての構成を備えるものに限定されず、その構成の一部を削除したものも含まれる。また、上記の各構成、機能等は、それらの一部又は全部を、例えば集積回路で設計する等により実現してもよい。また、上記の各構成、機能等は、プロセッサがそれぞれの機能を実現するプログラムを解釈し、実行することによりソフトウェアで実現してもよい。
Claims (4)
- 検体容器に収容された液体の検体を吸引した後、他の検体容器へ吐出して分注する分注処理を行う前処理装置であって、
分注ノズルと、
前記分注ノズルの先端に着脱可能に設けられた分注ノズルチップと、
前記分注ノズルから前記分注ノズルチップを取り外して廃棄する廃棄ボックスと、
前記分注ノズルから前記分注ノズルチップを取り外す取り外し部に挿入された前記分注ノズルチップを長手方向側方から切断する切断機構と
を備えたことを特徴とする前処理装置。 - 請求項1記載の前処理装置において、
前記切断機構は、
前記分注ノズルチップの側面に異なる方向から当接するよう連続的に形成された第1刃面および第2刃面を有し、前記第1刃面と前記第2刃面とを含む平面に沿う方向に回動可能に設けられた第1の刃と、
前記第1の刃の前記第1刃面および前記第2刃面とは異なる方向から前記分注ノズルチップの側面に当接するように形成された刃面を有し、前記第1の刃に対して相対的に固定された第2の刃とを備え、
前記第1の刃と前記第2の刃との間に前記分注ノズルチップを配置した状態で前記第1の刃を前記第2の刃の方向に回動させることで、前記第1の刃の前記第1刃面および前記第2刃面と前記第2の刃の刃面とで画定される範囲に前記分注ノズルチップを保持しながら切断することを特徴とする前処理装置。 - 請求項2記載の前処理装置において、
複数の前記切断機構と、
前記複数の切断機構のそれぞれの前記第1の刃を連結する連結部材と、
前記複数の切断機構にそれぞれ配置された複数の前記分注ノズルチップを一時に切断するように、前記複数の切断機構のそれぞれの前記第1の刃を前記連結部材を介して回動させるアクチュエータと
を有することを特徴とする前処理装置。 - 請求項2記載の前処理装置において、
前記切断機構は、
前記第1の刃と同軸状に回動可能に設けられ、前記分注ノズルチップの側面に前記第1の刃の前記第1刃面に沿って当接するとともに、前記第1の刃の前記第1刃面に沿う位置から前記分注ノズルチップ側への前記第1の刃に対する相対的な回動を抑制される第1のチップ保持部材と、
前記第1のチップ保持部材とは異なる方向から前記分注ノズルチップの側面に当接し、前記第2の刃の刃面に沿うように設けられた第2のチップ保持部材と、
前記第1のチップ保持部材を前記分注ノズルチップ側に付勢し、前記第1の刃の前記分注ノズルチップ側への回動に伴って前記第1のチップ保持部材を回動させて、前記第2のチップ保持部材との間で前記分注ノズルチップを把持させる弾性体とを有することを特徴とする前処理装置。
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JP2007139470A (ja) * | 2005-11-15 | 2007-06-07 | Aloka Co Ltd | ノズルチップ廃棄装置 |
JP2008039674A (ja) * | 2006-08-09 | 2008-02-21 | Canon Inc | ピペットチップの収納方法 |
US20190241858A1 (en) * | 2018-02-03 | 2019-08-08 | Singer Instrument Company Limited | An Apparatus and A Method for Transferring Material |
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JP2007139470A (ja) * | 2005-11-15 | 2007-06-07 | Aloka Co Ltd | ノズルチップ廃棄装置 |
JP2008039674A (ja) * | 2006-08-09 | 2008-02-21 | Canon Inc | ピペットチップの収納方法 |
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