WO2023024196A1

WO2023024196A1 - Material ball screening device

Info

Publication number: WO2023024196A1
Application number: PCT/CN2021/118895
Authority: WO
Inventors: 蒋析文; 刘霭珊; 郑桑桑; 谢晓成
Original assignee: 广州达安基因股份有限公司
Priority date: 2021-08-26
Filing date: 2021-09-17
Publication date: 2023-03-02
Also published as: CN115722436A

Abstract

A material ball screening device, comprising: a feeding portion, wherein the feeding portion is provided with a feeding cavity, and the feeding cavity is provided with a feeding port at the top and a discharging port at the bottom; a screening pipeline which is obliquely arranged, wherein the top of the screening pipeline is in communication with the discharging port of the feeding portion, and at least part of a lower side of the screening pipeline is provided with a screening member; and a drying portion, wherein the feeding portion and the screening pipeline are arranged in a drying cavity of the drying portion. The material ball screening device can achieve the purpose of automatic screening, and can avoid the problems of shrinkage and wall adhesion caused by the moisture absorption of material balls.

Description

Material Ball Screening Device

Related Application Cross Reference

This patent application claims the priority of the Chinese patent application with the application number 2021109886836 and the invention title "Material Ball Screening Device" filed on August 26, 2021. The entirety of the above application is incorporated herein by reference.

technical field

The application relates to the biomedical field, in particular to a material ball screening device.

Background technique

Biological agents have high requirements for their storage environment during use, and high temperature will damage their activity. In the prior art, cold chain transportation and low-temperature storage are often used to keep alive, but this storage method has disadvantages such as instability, high cost, and short shelf life. In order to overcome the above shortcomings, a new technology in the field of freeze-drying has been developed, that is, freeze-dried bead technology. Packed into eight-tube tubes, centrifuge tubes, microfluidic chips, various biochip cards, flow tubes, 96-well plates and other packaging materials, and can be stored at room temperature to achieve rapid diagnosis. Because there is no limitation of packaging materials, its production capacity can reach the limit of the freeze dryer. However, there are also disadvantages in the production of freeze-dried beads. It is very difficult to develop, and it is very fragile and easy to drop powder, and because of its small size and light weight, it is easy to rub and generate static electricity; if it is in contact with air for a long time, it is easy to absorb moisture and shrink, so The requirements for the screening environment and screening equipment are very strict. At present, the screening is usually performed manually in the market, which is one of the reasons why the large-scale production of freeze-dried beads has been delayed.

Contents of the invention

The purpose of this application is to provide a material ball screening device. The material ball screening device of this application realizes the purpose of automatic screening and avoids the problem of material balls absorbing moisture, shrinking and sticking to the wall.

In order to solve the above technical problems, the first aspect of the present application provides a material ball screening device, including: a feeding part, the feeding part has a feeding cavity, and the feeding cavity has a top feeding port and a bottom discharge port; A screening pipeline, the screening pipeline is arranged obliquely and the top of the screening pipeline communicates with the discharge port of the feeding part, at least a part of the lower side of the screening pipeline is provided with a screening piece; a drying part, the feeding part and the screening pipeline are arranged in the drying chamber of the drying part.

In an embodiment of the first aspect, a vibrating device is further included, the vibrating device is associated with the screening element and configured to drive the screening element to vibrate.

In the embodiment of the first aspect, it also includes a recovery pipeline, the recovery pipeline is arranged obliquely and arranged in the drying chamber and below the screening pipeline, so as to recover the materials screened below the screening element ball.

In an embodiment of the first aspect, at least a part of the recovery pipeline is provided with a mesh communicating with the drying chamber.

In an embodiment of the first aspect, the feeding opening of the feeding portion is provided with an operable opening and closing sealing cover.

In an embodiment of the first aspect, the screening element is detachably connected to the screening conduit.

In an embodiment of the first aspect, the screening member is a screen, and the meshes of the screen are circular holes.

In an embodiment of the first aspect, a recovery part is further included, the recovery part communicates with the lower end of the recovery pipeline and is used for receiving material balls obtained from the recovery pipeline.

In an embodiment of the first aspect, a charging part is further included, the charging part communicates with the lower end of the screening pipeline and is used for receiving material balls from the screening pipeline.

In an embodiment of the first aspect, the inner wall surfaces of the feeding part, the screening pipeline and the charging part are all coated with an antistatic layer.

Compared with the prior art, the embodiment of the present application realizes the automatic screening of the material balls by setting the screening parts, and avoids the material balls from being in contact with the air for a long time by setting the screening device in the drying chamber. And the problem of moisture absorption and shrinkage sticking to the wall.

Description of drawings

Fig. 1 shows the structural representation of the material ball screening device in an embodiment of the present application;

Fig. 2 is a schematic structural diagram of a material ball screening device including freeze-dried beads in an embodiment of the present application.

specific embodiment

Embodiments of the present application are described below through specific examples, and those skilled in the art can easily understand other advantages and effects of the present application from the content disclosed in this specification. The present application can also be implemented or applied in different specific implementation modes, and various modifications or changes can be made to the details in this specification based on different viewpoints and applied systems without departing from the spirit of the present application. It should be noted that, in the case of no conflict, the embodiments in the present application and the features in the embodiments can be combined with each other.

The embodiments of the present application will be described in detail below with reference to the accompanying drawings, so that those skilled in the art of the present application can easily implement them. The present application can be embodied in various forms, and is not limited to the embodiments described here.

In order to clarify the present application, components irrelevant to the description are omitted, and the same or similar components are given the same reference signs throughout the specification.

Throughout the specification, when it is said that a device is "connected" to another device, this includes not only the case of "direct connection" but also the case of "indirect connection" with other elements interposed therebetween. In addition, when it is said that a certain device "includes" a certain component, unless there is a specific statement to the contrary, it does not exclude other components, but means that other components may also be included.

When an element is said to be "on" another element, it can be directly on the other element, but it can also be with other elements in between. When a reference is made to say that an element is "directly on" another element, the other elements are not intervening.

Although in some instances the terms first, second, etc. are used herein to describe various elements, these elements should not be limited by these terms. These terms are only used to distinguish one element from another. For example, the first interface and the second interface are described. Furthermore, as used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context indicates otherwise. It should be further understood that the terms "comprising", "comprising" indicate the presence of stated features, steps, operations, elements, components, items, species, and/or groups, but do not exclude one or more other features, steps, operations, The existence, occurrence or addition of an element, component, item, species, and/or group. The terms "or" and "and/or" as used herein are to be construed as inclusive, or to mean either one or any combination. Thus, "A, B or C" or "A, B and/or C" means "any of the following: A; B; C; A and B; A and C; B and C; A, B and C" . Exceptions to this definition will only arise when combinations of elements, functions, steps or operations are inherently mutually exclusive in some way.

The terminology used herein is only used to refer to specific embodiments, and is not intended to limit the application. The singular form used here also includes the plural form as long as the statement does not clearly indicate the opposite meaning. The meaning of "comprising" used in the description is to specify specific characteristics, regions, integers, steps, operations, elements and/or components, not to exclude other characteristics, regions, integers, steps, operations, elements and/or components exists or is attached.

Relative spatial terms denoting "below", "upper", etc. may be used in order to more easily explain the relationship of one device relative to another device illustrated in the drawings. Such terms mean not only the meaning indicated in the drawings but also other meanings or operations of the device in use. For example, if the device in the figures is turned over, elements described as "under" other elements would then be oriented "above" the other elements. Therefore, the exemplary term "under" includes all above and below. The device may be rotated by 90° or at other angles, and relative spatial terms are to be construed accordingly.

Although not differently defined, all terms including technical terms and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which this application belongs. The terms defined in commonly used dictionaries are additionally interpreted as having meanings consistent with the contents of relevant technical documents and current prompts, and as long as they are not defined, they should not be excessively interpreted as ideal or very formulaic meanings.

The material ball screening device of the present application includes a feeding part, a screening pipeline and a drying part, wherein the feeding part has a feeding chamber, and the feeding chamber has a feeding opening at the top and a discharge opening at the bottom; The discharge port is connected, and at least a part of the lower side of the screening pipeline is provided with a screening piece; the feeding part and the screening pipeline are arranged in the drying chamber of the drying part. The material balls to be packed in this embodiment are freeze-dried beads as an example, and may actually be other forms of material balls.

The following describes the first embodiment of the application with reference to the accompanying drawings, as shown in Figure 1 and Figure 2, the material ball screening device of the present application comprises a feeding part 1, a screening pipeline 2 and a drying part 3, the feeding part 1 has a feeding chamber 10, and the feeding part The cavity 10 includes a feeding opening 11 at the top and a feeding opening 12 at the bottom. Specifically, the discharge port 12 at the bottom of the feeding chamber 10 communicates with the top of the screening pipeline 2 below. The screening pipeline 2 is arranged obliquely downward from the top, so that for example, the material ball of freeze-dried beads enters the screening pipeline 2 from the feeding chamber 10 and helps it to slide down obliquely. The lower side of the screening pipeline 2 is provided with a

screening piece

21, 21 can be arranged at a part of the lower side of the screening pipeline 2, and also can be all of the lower side. The screening member 21 can be a screen or other forms. The mesh of the screen can be a circular hole or other shapes, all of which do not depart from the protection scope of the present application. The screening element 21 and the screening pipeline 2 can be fixedly connected or detachably connected. The screening device can replace screening parts with meshes of different sizes according to needs, thereby improving the equipment reutilization rate. The screening element 21 can screen the freeze-dried beads smaller than the preset size out of the screening channel 2 , so as to ensure that only the freeze-dried beads meeting the preset size requirements pass through the screening channel 2 . In addition, the feeding port 11 can also be provided with a sealing cover (not shown in the figure). After the freeze-dried beads are dropped into the feeding chamber 10, the feeding port 11 is closed by the sealing cover, which can isolate the air from entering the feeding chamber 10, making the feeding chamber A relatively closed space is formed in 10 to avoid the continuous entry of humid air during the screening process, which will cause the freeze-dried beads to shrink or stick to the wall due to moisture absorption. In addition, a feeding screen can also be set between the discharge port 12 at the bottom of the feeding chamber 10 and the top of the screening pipeline 2, and the screen mesh can be provided with freeze-dried beads slightly larger than the preset qualified size, such as the screen mesh The diameter may be greater than 10%-40% of the preset qualified diameter of the freeze-dried beads, so that the larger size or multiple bonded freeze-dried beads are screened out through the feeding screen.

The material ball screening device of the present application further includes a drying part 3 , and the drying part 3 has a drying chamber 30 . Specifically, the feeding part 1 and the screening pipeline 2 can be arranged in the drying chamber 30 of the drying part 3, so as to ensure that the freeze-dried beads are always in a dry environment during the screening process, and avoid shrinkage or sticking of the freeze-dried beads due to moisture absorption. . In some embodiments, at least part of the feeding part 1 is provided with a plurality of meshes communicated with the drying chamber 30, and at least part of the screening pipeline 2 is provided with a plurality of meshes communicated with the drying chamber 30, so as to facilitate the drying of the air. It enters the feeding part 1 and the screening pipeline 2 to achieve better drying efficiency.

A recovery pipeline 4 may also be arranged below the screening pipeline 2 of the material ball screening device of the present application. Specifically, the recovery pipeline 4 is also arranged obliquely downward, preferably, the recovery pipeline 4 is arranged in parallel with the screening pipeline 2 . The recovery pipeline 4 is used for recovering the freeze-dried beads screened to the bottom through the screening element 21 in the screening pipeline 2 . At least a part of the recovery pipeline 4 is provided with a plurality of meshes communicated with the drying chamber 30, and the mesh is smaller than the basic size of the freeze-dried beads, so as to prevent the freeze-dried beads screened into the recovery pipeline 4 from falling to the bottom of the recovery pipeline 4 again, At the same time, the recovery pipeline 4 communicates with the drying chamber 30 to achieve better drying efficiency.

In addition, a charging section 5 can also be connected to the lower end of the screening pipeline 2 . Specifically, the charging part 5 communicates with the lower end of the screening pipeline 2 for receiving freeze-dried beads from the screening pipeline 2 . Similarly, a recovery unit 6 can also be connected to the lower end of the recovery pipeline 4. The recovery unit 6 is used to receive the freeze-dried beads from the recovery pipeline 4. The recovery unit 6 is detachably connected to facilitate cleaning of the recovered freeze-dried beads. In some embodiments, the screening device of the present application further includes a vibrating device (not shown in the figure), which is associated with the screening part 21 and can drive the screening part 21 to vibrate. When the vibrating device is working, the screening part 21 generates low-frequency vibrations, which can prevent the freeze-dried beads from being crowded and stuck in the screening pipeline 2 and cause the screening to not proceed smoothly, thereby improving the screening efficiency. Vibration devices can also be provided in multiples and arranged at intervals on the screening member 21, so that each section can obtain uniform vibration intensity.

The screening device of the present application can be made of plastic materials such as PP, PE or PET, and an antistatic layer is coated on the inner wall surface that the freeze-dried beads may contact, for example, the inner wall surface of the feeding part, the screening pipeline, the recovery pipeline and the charging part are coated with The anti-static layer can also be made of metal materials such as stainless steel. By grounding it, it has the function of eliminating static electricity, so as to minimize the problems of freeze-dried beads sticking to the wall and blocking the wall due to static electricity.

The screening device for material balls in this application realizes the automatic screening of material balls by setting screening parts, and screens out the material balls that do not meet the size requirements. The problem of moisture absorption and shrinkage sticking to the wall.

The above-mentioned embodiments are only illustrative to illustrate the principles and effects of the present application, but are not intended to limit the present application. Any person familiar with the technology can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present application. Therefore, all equivalent modifications or changes made by those skilled in the art without departing from the spirit and technical ideas disclosed in the application shall still be covered by the claims of the application.

Claims

A material ball screening device is characterized in that it comprises:

A feeding part, the feeding part has a feeding chamber, and the feeding chamber has a feeding port at the top and a feeding port at the bottom;

A screening pipeline, the screening pipeline is arranged obliquely and the top of the screening pipeline communicates with the discharge port of the feeding part, and at least a part of the lower side of the screening pipeline is provided with a screening piece;

In the drying section, the feeding section and the screening pipeline are arranged in a drying chamber of the drying section.
The material ball screening device according to claim 1, further comprising a vibrating device associated with the screening element and configured to drive the screening element to vibrate.
The material ball screening device according to claim 1, further comprising a recovery pipeline, the recovery pipeline is arranged obliquely and arranged in the drying chamber and below the screening pipeline for recycling and screening to Material balls below the screen.
The material ball screening device according to claim 3, characterized in that at least a part of the recovery pipeline is provided with a mesh communicating with the drying chamber.
The material ball screening device according to claim 1, characterized in that, the feeding opening of the feeding part is provided with an operable opening and closing sealing cover.
The material ball screening device according to claim 1, characterized in that, the screening element is detachably connected to the screening pipeline.
The material ball screening device according to claim 1, characterized in that, the screening member is a screen, and the meshes of the screen are circular holes.
The device for screening material balls according to claim 3, further comprising a recovery part, the recovery part communicates with the lower end of the recovery pipeline and is used to receive the material balls obtained from the recovery pipeline.
The device for screening material balls according to claim 1, further comprising a charging part, the charging part communicates with the lower end of the screening pipeline and is used to receive the material balls from the screening pipeline.
According to the material ball screening device according to any one of claims 1-9, it is characterized in that the inner wall surfaces of the feeding part, the screening pipeline and the charging part are all coated with an antistatic layer.