WO2023019798A1 - Dispositif de source d'ions portatif et spectromètre de masse - Google Patents

Dispositif de source d'ions portatif et spectromètre de masse Download PDF

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Publication number
WO2023019798A1
WO2023019798A1 PCT/CN2021/134024 CN2021134024W WO2023019798A1 WO 2023019798 A1 WO2023019798 A1 WO 2023019798A1 CN 2021134024 W CN2021134024 W CN 2021134024W WO 2023019798 A1 WO2023019798 A1 WO 2023019798A1
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WO
WIPO (PCT)
Prior art keywords
voltage
ion source
electrode
source device
circuit
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Application number
PCT/CN2021/134024
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English (en)
Chinese (zh)
Inventor
聂宗秀
李玉泽
孟令炜
熊彩侨
刘会会
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中国科学院化学研究所
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Application filed by 中国科学院化学研究所 filed Critical 中国科学院化学研究所
Publication of WO2023019798A1 publication Critical patent/WO2023019798A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J7/00—Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02M—APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF
    • H02M7/00—Conversion of ac power input into dc power output; Conversion of dc power input into ac power output
    • H02M7/42—Conversion of dc power input into ac power output without possibility of reversal
    • H02M7/44—Conversion of dc power input into ac power output without possibility of reversal by static converters
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02M—APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF
    • H02M7/00—Conversion of ac power input into dc power output; Conversion of dc power input into ac power output
    • H02M7/42—Conversion of dc power input into ac power output without possibility of reversal
    • H02M7/44—Conversion of dc power input into ac power output without possibility of reversal by static converters
    • H02M7/48—Conversion of dc power input into ac power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode
    • H02M7/53—Conversion of dc power input into ac power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal
    • H02M7/537—Conversion of dc power input into ac power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters

Definitions

  • the present application relates to the technical field of ion sources, in particular to a handheld ion source device and a mass spectrometer.
  • Modern mass spectrometers have the advantages of fast analysis speed, high accuracy, good sensitivity, and simultaneous analysis of multiple species, so they are widely used in life sciences, environmental monitoring, forensic identification, anti-drug and anti-terrorism and other fields.
  • life sciences can use large-scale mass spectrometers in the central laboratory, while environmental monitoring, forensic identification, anti-drug and anti-terrorism and other fields that require on-site testing can only use vehicle-mounted or even portable small mass spectrometers, which are equipped with paper spray, electrospray, Open ion sources such as direct analysis in real time (DART). Although these open ion source devices themselves are not large, they generally need to be connected to devices such as gas cylinders, syringe pumps, and high-voltage power supplies.
  • This application proposes a hand-held ion source device and a mass spectrometer to facilitate on-site detection work.
  • the application proposes a handheld ion source device, including a battery, an oscillating circuit, a micro air pump, a switch circuit, a boost coil, a high-voltage electrode and a ground electrode, and the boost coil includes a primary coil and a secondary coil , wherein the first pole of the battery is connected to the first end of the oscillating circuit and the first end of the primary coil, the second stage of the battery is connected to the first end of the micro air pump, the The second end of the primary coil is connected to the first end of the switch circuit, the second end of the oscillation circuit is connected to the second end of the switch circuit, the third end of the oscillation circuit is connected to the switch circuit The third end, the second end of the micro air pump are connected and grounded, the first end of the secondary coil is connected to the ground electrode, and the second end of the secondary coil is connected to the high voltage electrode, wherein, The battery is used to provide low-voltage direct current, the oscillating circuit is used to control the switch circuit to convert the low-voltage
  • the battery is used for power supply, and the low-voltage power provided by the battery is converted to high-voltage power by using an oscillating circuit, a switch circuit and a booster coil, so that there is no need to configure a high-voltage power supply and an iron stand and other supporting devices make the hand-held ion source simple in structure and small in size, which facilitates the development of on-site detection work and is conducive to rapid detection.
  • the present application proposes a mass spectrometer, including the above-mentioned handheld ion source device.
  • the battery is used for power supply, and the low-voltage power provided by the battery is converted to high-voltage power by using the oscillating circuit, the switching circuit and the booster coil, so that there is no need to configure high-voltage power supply, iron stand and other supporting devices , so that the hand-held ion source has a simple structure and a small size, which facilitates the development of on-site detection work and is conducive to rapid detection.
  • Fig. 1 is a schematic circuit diagram of a hand-held ion source device according to an embodiment of the present application
  • Fig. 2 is the schematic diagram of the hand-held ion source device of an example of the present application
  • Fig. 3 is the working result figure of the hand-held ion source device of an example of the present application.
  • Fig. 4 (a), (b) is the working schematic diagram of the hand-held ion source device of an example of the present application;
  • Fig. 5 is a structural block diagram of a mass spectrometer according to an embodiment of the present application.
  • Fig. 1 is a schematic structural diagram of a hand-held ion source device according to an embodiment of the present application.
  • the handheld ion source device 100 includes: a battery BT1 , a switch circuit 101 , an oscillation circuit 102 , a micro air pump 103 , a boost coil 104 , a high voltage electrode 6 , and a ground electrode 5 .
  • the boost coil 104 includes a primary coil and a secondary coil, the first pole of the battery BT1 is connected to the first end of the oscillation circuit 102 and the first end of the primary coil respectively, and the second pole of the battery BT1 is connected to the first end of the micro air pump 103 One end is connected, the second end of the primary coil is connected to the first end of the switch circuit 101, the second end of the oscillation circuit 102 is connected to the second end of the switch circuit 101, the third end of the oscillation circuit 102 is connected to the first end of the switch circuit 101
  • the three terminals and the second terminal of the micro air pump 103 are respectively connected and grounded, the first terminal of the secondary coil is connected to the ground electrode 5 , and the second terminal of the secondary coil is connected to the high voltage electrode 6 .
  • the above-mentioned battery BT1 is used to provide low-voltage direct current
  • the oscillation circuit 102 is used to control the switch circuit 101 to convert the low-voltage direct current provided by the battery BT1 into low-voltage alternating current
  • the booster coil 104 is used to boost the low-voltage alternating current to obtain high-voltage electric power
  • high-voltage electrode 6 to realize HV OUT namely high-voltage output, thereby provide high-voltage electricity through high-voltage electrode 6.
  • the above-mentioned battery BT1 may be a rechargeable battery, for example, a 3.7V lithium battery or the like.
  • the switch circuit 101 includes a field effect transistor, and the control terminal of the field effect transistor is connected with the second terminal of the oscillation circuit 102 .
  • the oscillating circuit 102 outputs an oscillating current through its second terminal, so as to control the field effect tube through the oscillating current, for example, it can control the opening and closing of the field effect tube, so that the current flowing through the field effect tube changes, that is, the The current of the primary coil of the pressure coil changes, thereby converting the low-voltage direct current provided by the battery BT1 into low-voltage alternating current.
  • the low-voltage direct current drives the oscillating circuit 102 to work to output an oscillating current to the switch circuit 101 to control the opening and closing of the switching circuit 101, thereby utilizing the opening and closing of the switching circuit 101 to convert the low-voltage direct current into a low-voltage
  • the booster coil 104 converts the low-voltage alternating current into high-voltage electric power, without high-voltage power supply, iron frame and other supporting devices, which makes the handheld ion source device 100 compact and convenient, reduces costs, and facilitates rapid on-site detection.
  • the above hand-held ion source device 100 also includes: a micro air pump switch 1 and an oscillation circuit switch 2 , the micro air pump switch 1 is connected in series with the micro air pump 103 , and the oscillation circuit switch 2 is connected in series with the oscillation circuit 102 .
  • the micro-air pump switch 1 can control the on-off of the micro-air pump 103
  • the oscillating circuit switch 2 can control the on-off of the oscillating circuit 102 . In this way, it is possible to use a switch to control the opening and closing of the micro air pump 103 and the boost coil 104, thereby further improving the convenience of the hand-held ion source.
  • the above hand-held ion source device 100 also includes a hand-held housing, in which the battery BT1, the switch circuit 101, the oscillation circuit 102, the micro air pump 103, and the boost coil 104 are all arranged.
  • the length, width and height of the above-mentioned hand-held housing are 100-140 mm, 10-30 mm, and 10-30 mm respectively, and the length of the part of the high-voltage electrode 6 and the ground electrode 5 protruding from the hand-held housing is 10-30 mm.
  • the length, width and height of the hand-held housing may be, for example, 120 mm, 20 mm, and 20 mm respectively, and the length of the part of the high-voltage electrode 6 and ground electrode 5 protruding from the hand-held housing may be, for example, 20 mm.
  • the handheld ion source can be integrated into a handheld housing, so that the handheld ion source has a small structure and can be operated with one hand, and the detection speed can be improved due to the simple structure.
  • the high voltage electrode 6 and the ground electrode 5 can be arranged close to each other to ionize the gas pumped by the micro gas pump 103 between the high voltage electrode 6 and the ground electrode 5 to obtain plasma.
  • the micro air pump 103 is also used to blow the plasma toward the direction of the sample or the direction of the entrance of the mass spectrometer, so that the mass spectrometer can detect the sample.
  • the micro-air pump 103 pumps the air between the high-voltage electrode 6 and the ground electrode 5, and the high-voltage electrode 6 and the ground electrode 5 are arranged close to each other for direct discharge, thereby ionizing the air pumped out by the micro-air pump 103, generating a large amount of The ionization of the sample can be achieved by these plasmas being close to the sample.
  • the shape of the above-mentioned sample can be gas, liquid, or solid surface.
  • air can be directly pumped out by the micro-air pump 103 to supply gas to the ion source, without carrying a gas bottle, which greatly improves the convenience of the handheld ion source.
  • the handheld ion source device 100 of the embodiment of the present application will be described in detail below with reference to the specific example shown in FIG. 2 .
  • 3 is the above-mentioned hand-held housing, and 4 is the gas outlet of the micro air pump.
  • the above sample is caffeine on the surface of aluminum block.
  • the user presses the micro air pump switch 1 and the oscillation circuit switch 2, the battery BT1 provides low-voltage direct current to drive the micro air pump 103 to work, and the oscillation circuit 102 controls the switch circuit 101 to invert the low-voltage direct current provided by the battery BT1 into low-voltage alternating current.
  • the booster coil 104 boosts the low-voltage AC power to obtain high-voltage power.
  • the high-voltage electrode 6 and the ground electrode 5 are placed close to each other to ionize the air pumped from the gas outlet 4 of the micro air pump to obtain directional plasma.
  • the mass spectrometry instrument adopts LTQ, and can adopt tandem mass spectrometry mode to selectively monitor caffeine [M+H] + parent ion m/z195, as shown in Figure 3, a strong m/z195 ion was found, and it was also found The characteristic fragment m/z138 of caffeine was detected, the overall signal intensity of the spectrum was about 1 ⁇ 10 4 , and the detection effect was good.
  • the high voltage electrode 6 and the ground electrode 5 can be arranged far away. At this time, the generated plasma can be blown toward the entrance of the mass spectrometer by the micro air pump 103 .
  • the hand-held ion source device 100 also includes a high-voltage connector connected to the tip of the high-voltage electrode 6 , wherein the high-voltage electrode 6 is used to provide high-voltage electricity to other ion source devices through the high-voltage connector.
  • the above-mentioned high-voltage connector is an alligator clip 7, and the above-mentioned other ion source device is a paper spray device, wherein the alligator clip 7 is used to clamp the triangular paper of the paper spray device added with a liquid sample 8.
  • the high-voltage electrode 6 can be used to provide high-voltage electricity to the paper spray device, so that the liquid sample on the triangular paper 8 is ionized, and the ionization result enters the mass spectrometer inlet 9 .
  • the above-mentioned high-voltage connector is a platinum electrode 10
  • the above-mentioned other ion source device is a nanoliter electrospray device
  • the platinum electrode is used to be inserted into the nozzle 11 of the nanoliter electrospray device.
  • the high-voltage electrode 6 can be used to provide high-voltage electricity to the nanoliter electrospray device, so that the liquid sample is ionized, and the ionization result enters the mass spectrometer inlet 9 .
  • the above-mentioned high-voltage connecting member and the above-mentioned other ion source devices may also be implemented in other possible manners, which are not limited in this application.
  • the micro air pump switch 1 can also be set in series with the primary coil. Specifically, the micro air pump switch 1 and the oscillation circuit switch 2 are controlled to be closed, so that the micro air pump 103 and the boost coil 104 work.
  • the micro air pump 103 pumps out the air, and the inverter circuit oscillating circuit 102 inverts the low-voltage direct current provided by the battery BT1 into a low-voltage alternating current, and the booster coil 104 boosts the low-voltage alternating current to obtain high-voltage power. Closely placed to ionize the air pumped by the micropump, resulting in a directional plasma.
  • only the oscillating circuit switch 2 can be set in series with the oscillating circuit 102, without the micro air pump switch 1, so that the user can control the work of the hand-held ion source device only by pressing the oscillating circuit switch 2, further improving the hand-held ion source. Convenience of the ion source unit.
  • the handheld ion source device of the embodiment of the present application uses a battery for power supply, and utilizes an oscillating circuit, a switch circuit, and a boost coil to convert the low-voltage power provided by the battery to obtain high-voltage power, so that there is no need to configure a high-voltage power supply
  • iron Supporting devices such as a stand make the handheld ion source simple in structure and small in size, which facilitates the development of on-site detection work and is conducive to rapid detection.
  • a micro air pump is used to pump out air to supply air to the ion source, and there is no need to carry an additional gas cylinder, thereby further improving the portability of the ion source.
  • devices such as high-voltage power supply, iron stand, and gas cylinder are omitted, costs can also be saved.
  • the present application proposes a mass spectrometer.
  • Fig. 5 is a structural block diagram of a mass spectrometer according to an embodiment of the present application.
  • the mass spectrometer 200 includes a handheld ion source device 100 .
  • the mass spectrometer of the embodiment of the present application through the above-mentioned hand-held ion source device, can be powered by a battery, and the low-voltage power provided by the battery can be converted to high-voltage power by using an oscillating circuit, a switching circuit and a booster coil, thereby eliminating the need for Equipped with high-voltage power supply, iron stand and other supporting devices, the handheld ion source has a simple structure and a small size, which facilitates the development of on-site detection work and is conducive to rapid detection. Moreover, a micro air pump is used to pump out air to supply air to the ion source, and there is no need to carry an additional gas cylinder, thereby further improving the portability of the ion source. At the same time, because devices such as high-voltage power supply, iron stand, and gas cylinder are omitted, costs can also be saved.
  • first and second are used for descriptive purposes only, and cannot be interpreted as indicating or implying relative importance or implicitly specifying the quantity of indicated technical features.
  • the features defined as “first” and “second” may explicitly or implicitly include at least one of these features.
  • “plurality” means at least two, such as two, three, etc., unless otherwise specifically defined.
  • a first feature being "on” or “under” a second feature may mean that the first and second features are in direct contact, or that the first and second features are indirect through an intermediary. touch.
  • “above”, “above” and “above” the first feature on the second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature.
  • “Below”, “beneath” and “beneath” the first feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is less horizontally than the second feature.

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  • Engineering & Computer Science (AREA)
  • Power Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Plasma & Fusion (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

L'invention concerne un dispositif de source d'ions portatif (100) et un spectromètre de masse (200), qui se rapportent au domaine technique des sources d'ions. Le dispositif (100) comprend une batterie (BT1), un circuit oscillant (102), une pompe à micro-air (103), un circuit de commutation (101), une électrode haute tension (6), une électrode de masse (5), et une bobine d'amplification (104) comprenant une bobine primaire et une bobine secondaire. Une première électrode de la batterie (BT1) est reliée au circuit oscillant (102) et à une première borne de la bobine primaire ; une seconde électrode de la batterie (BT1) est reliée à une première borne de la pompe à micro-air (103) ; des première et seconde bornes du circuit de commutation (101) sont connectées de manière correspondante à une seconde borne de la bobine primaire et à une seconde borne du circuit d'oscillation (102) ; et des première et seconde bornes de la bobine secondaire sont connectées de manière correspondante à l'électrode de masse (5) et à l'électrode haute tension (6). Le circuit oscillant (102) commande le circuit de commutation (101) de manière à convertir un courant continu basse tension fourni par la batterie (BT1) en un courant alternatif basse tension, et la bobine d'amplification amplifie le courant alternatif basse tension pour obtenir un courant à haute tension, et fournit le courant à haute tension au moyen de l'électrode haute tension.
PCT/CN2021/134024 2021-08-16 2021-11-29 Dispositif de source d'ions portatif et spectromètre de masse WO2023019798A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202110935682.5A CN115705993A (zh) 2021-08-16 2021-08-16 手持式离子源装置以及质谱仪
CN202110935682.5 2021-08-16

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WO2023019798A1 true WO2023019798A1 (fr) 2023-02-23

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103023336A (zh) * 2013-01-09 2013-04-03 魏传永 手持式高压灭苍蝇拍
CN103301499A (zh) * 2013-06-29 2013-09-18 何林 空气负离子净化器
CN103760147A (zh) * 2014-01-20 2014-04-30 段忆翔 基于微型等离子体的手持式化学挥发物检测仪
CN203658267U (zh) * 2014-01-20 2014-06-18 段忆翔 基于微型等离子体的手持式化学挥发物检测仪
US20140183350A1 (en) * 2012-12-31 2014-07-03 908 Devices Inc. Compact Mass Spectrometer
CN109075016A (zh) * 2016-05-13 2018-12-21 英国质谱公司 用于敞开式电离离子源的封装件

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140183350A1 (en) * 2012-12-31 2014-07-03 908 Devices Inc. Compact Mass Spectrometer
CN103023336A (zh) * 2013-01-09 2013-04-03 魏传永 手持式高压灭苍蝇拍
CN103301499A (zh) * 2013-06-29 2013-09-18 何林 空气负离子净化器
CN103760147A (zh) * 2014-01-20 2014-04-30 段忆翔 基于微型等离子体的手持式化学挥发物检测仪
CN203658267U (zh) * 2014-01-20 2014-06-18 段忆翔 基于微型等离子体的手持式化学挥发物检测仪
CN109075016A (zh) * 2016-05-13 2018-12-21 英国质谱公司 用于敞开式电离离子源的封装件

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