WO2023012264A3 - Activateur pharmacologique et/ou genetique pour son utilisation pour preserver et regenerer la structure et la fonction musculaire en bloquant la senescence - Google Patents
Activateur pharmacologique et/ou genetique pour son utilisation pour preserver et regenerer la structure et la fonction musculaire en bloquant la senescence Download PDFInfo
- Publication number
- WO2023012264A3 WO2023012264A3 PCT/EP2022/071914 EP2022071914W WO2023012264A3 WO 2023012264 A3 WO2023012264 A3 WO 2023012264A3 EP 2022071914 W EP2022071914 W EP 2022071914W WO 2023012264 A3 WO2023012264 A3 WO 2023012264A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- activator
- function
- senescence
- preserving
- blocking
- Prior art date
Links
- 239000012190 activator Substances 0.000 title abstract 6
- 210000003205 muscle Anatomy 0.000 title abstract 3
- 230000000903 blocking effect Effects 0.000 title abstract 2
- 230000002068 genetic effect Effects 0.000 title abstract 2
- 230000000144 pharmacologic effect Effects 0.000 title abstract 2
- 230000001172 regenerating effect Effects 0.000 title abstract 2
- 230000009758 senescence Effects 0.000 title abstract 2
- 102000003911 Thyrotropin Receptors Human genes 0.000 abstract 5
- 108090000253 Thyrotropin Receptors Proteins 0.000 abstract 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 210000001665 muscle stem cell Anatomy 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
- 210000001057 smooth muscle myoblast Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
L'invention concerne un activateur pour son utilisation pour préserver et régénérer la structure et la fonction musculaire. L'invention se caractérise en ce que ledit activateur est un activateur de la voie de signalisation du récepteur de la thyréostimuline (TSHR) dans des cellules souches musculaires (cellules satellites) pour préserver et régénérer la structure et la fonction musculaire en bloquant la sénescence. L'invention concerne également une combinaison d'un activateur pharmacologique pour son utilisation selon l'invention et d'un activateur génétique pour son utilisation selon l'invention, ainsi qu'un vecteur adénoviral comprenant une séquence protéique du récepteur de la thyréostimuline (TSHR) de SEQ ID NO :1, ou une séquence nucléotidique du TSHR de SEQ ID NO :2 pour son utilisation à titre de médicament.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP22765409.2A EP4380965A2 (fr) | 2021-08-04 | 2022-08-04 | Activateur pharmacologique et/ou genetique pour son utilisation pour preserver et regenerer la structure et la fonction musculaire en bloquant la senescence |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FRFR2108489 | 2021-08-04 | ||
FR2108489A FR3126005A1 (fr) | 2021-08-04 | 2021-08-04 | Activateur pharmacologique et/ou génétique pour son utilisation pour préserver et régénérer la structure et la fonction musculaire en bloquant la sénescence |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2023012264A2 WO2023012264A2 (fr) | 2023-02-09 |
WO2023012264A3 true WO2023012264A3 (fr) | 2023-03-30 |
Family
ID=80122380
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2022/071914 WO2023012264A2 (fr) | 2021-08-04 | 2022-08-04 | Activateur pharmacologique et/ou genetique pour son utilisation pour preserver et regenerer la structure et la fonction musculaire en bloquant la senescence |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP4380965A2 (fr) |
FR (1) | FR3126005A1 (fr) |
WO (1) | WO2023012264A2 (fr) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991009137A1 (fr) * | 1989-12-20 | 1991-06-27 | Basil Rapoport | Recepteur de thyrotropine recombinant |
JP2021103947A (ja) * | 2019-12-26 | 2021-07-26 | ヤマサ醤油株式会社 | 変異が導入された甲状腺刺激ホルモン受容体 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018155913A1 (fr) | 2017-02-21 | 2018-08-30 | 성균관대학교산학협력단 | Procédé de différenciation en cellule de muscle squelettique à l'aide d'un composé de faible poids moléculaire |
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2021
- 2021-08-04 FR FR2108489A patent/FR3126005A1/fr active Pending
-
2022
- 2022-08-04 WO PCT/EP2022/071914 patent/WO2023012264A2/fr unknown
- 2022-08-04 EP EP22765409.2A patent/EP4380965A2/fr active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991009137A1 (fr) * | 1989-12-20 | 1991-06-27 | Basil Rapoport | Recepteur de thyrotropine recombinant |
JP2021103947A (ja) * | 2019-12-26 | 2021-07-26 | ヤマサ醤油株式会社 | 変異が導入された甲状腺刺激ホルモン受容体 |
Non-Patent Citations (2)
Title |
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MCINTOSH L.M. ET AL: "Hypothyroidism prolongs and increases mdx muscle precursor proliferation and delays myotube formation in normal and dystrophic limb muscle", vol. 73, no. 3-4, 1 March 1995 (1995-03-01), CA, pages 181 - 190, XP055929874, ISSN: 0829-8211, Retrieved from the Internet <URL:http://dx.doi.org/10.1139/o95-022> DOI: 10.1139/o95-022 * |
NEUMANN SUSANNE ET AL: "Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice", vol. 106, no. 30, 28 July 2009 (2009-07-28), pages 12471 - 12476, XP055929513, ISSN: 0027-8424, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708975/pdf/zpq12471.pdf> DOI: 10.1073/pnas.0904506106 * |
Also Published As
Publication number | Publication date |
---|---|
FR3126005A1 (fr) | 2023-02-10 |
EP4380965A2 (fr) | 2024-06-12 |
WO2023012264A2 (fr) | 2023-02-09 |
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