WO2023000210A1 - 具改良性质的外科手术缝线 - Google Patents

具改良性质的外科手术缝线 Download PDF

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Publication number
WO2023000210A1
WO2023000210A1 PCT/CN2021/107661 CN2021107661W WO2023000210A1 WO 2023000210 A1 WO2023000210 A1 WO 2023000210A1 CN 2021107661 W CN2021107661 W CN 2021107661W WO 2023000210 A1 WO2023000210 A1 WO 2023000210A1
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Prior art keywords
suture
surgical suture
cutting
molded
barbs
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PCT/CN2021/107661
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English (en)
French (fr)
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方旭伟
洪炜
苏真莹
江卓培
黄士豪
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台北科技大学
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Priority to PCT/CN2021/107661 priority Critical patent/WO2023000210A1/zh
Publication of WO2023000210A1 publication Critical patent/WO2023000210A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials

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  • the present application relates to a surgical suture with enhanced pulling force and no protrusion on the tissue surface.
  • Surgical sutures add molded barbs to strengthen the tension. They are often used for wound suture in laparoscopic minimally invasive surgery. Because of the molded barb structure of the sutures, the tissues on both sides of the wound can be pulled closer, eliminating the need to lacerate the wound. The requirement of the knot, and the tensile strength of the suture itself can maintain the closure of the wound, and it is a widely used surgical suture at present.
  • the present application provides a surgical suture with improved properties, comprising a plurality of suture units, wherein each suture unit has at least two pairs of molded barbs and a plurality of cutting modifications, wherein each pair of molded The two molded barbs of the plastic barb extend towards the opposite direction, and the plurality of cutting modifications are located between the two pairs of molded barbs; and the cutting modification and another adjacent cutting modification are relative to the suture axis There is an included angle ⁇ , and ⁇ is between 0°-180°.
  • the length of the suture unit is equal to or less than 10 mm.
  • the plurality of cleavage modifications are arranged in a helical symmetry.
  • the cutting modification and another adjacent cutting modification have an included angle ⁇ with respect to the suture axis, and ⁇ is between 0°-180°, preferably between 15°-90°, more Preferably it is between 30°-90°.
  • ⁇ is less than 90°, preferably equal to or less than 45°, more preferably equal to or less than 30°.
  • the length of the molded barb 20 is equal to or less than 5 mm, preferably equal to or less than 1 mm.
  • the length of the suture unit is equal to or less than 10 mm.
  • each suture unit has at least two pairs of molded barbs and a plurality of cutting modifications arranged in spiral symmetry, and the distance between the helical cutting modification and another adjacent helical cutting is relative to the suture
  • the axis has an included angle ⁇ , ⁇ is 30-90°.
  • FIG. 1 is a schematic diagram of Reference Example 1 of the related prior art.
  • Fig. 2 is a schematic diagram of Reference Example 2 of the related prior art.
  • Fig. 3 is a cross-sectional view of Reference Example 2 of the related prior art.
  • Fig. 4 is a schematic diagram of Embodiment 1 of the present application.
  • Fig. 5 is a sectional view of Embodiment 1 of the present application.
  • the present application is to provide a surgical suture with improved properties, comprising a plurality of suture units, wherein each suture unit has at least 2 pairs of molded barbs and a plurality of cutting modifications, wherein two of each pair of molded barbs The molded barbs extend toward opposite directions, and the plurality of cutting modifications are located between the two pairs of molded barbs; and the cutting modification and another adjacent cutting modification have an included angle ⁇ with respect to the suture axis , ⁇ is between 0°-180°.
  • molded barbs are used to increase the tensile force
  • cutting is used to increase the elasticity of the suture.
  • the wire will be damaged due to cutting, and the overall tensile strength of the wire will decrease due to the damage of the overall suture. If the tension strength is too weak, it may not be possible to maintain the closure of the wound tissue.
  • the present application utilizes cutting technology to modify surgical sutures with molded barbs, so as to solve the problem that the current surgical sutures with molded barbs will cause raised and uneven tissue surfaces.
  • the suture is a means of shaping the surface of the suture into a barb-like structure by heating the mold and controlling the temperature below a specific temperature to heat and extrude the raw material of the surgical suture in the molding process.
  • Multiple groups of roller molds form single or multiple shapes of barbs on the surface of the same suture. Sutures with molded barbs are made, and then the cutting process is used to cut and modify the above-mentioned sutures that have been molded.
  • One specific embodiment of the present application is to use the cutter module required for cutting and the fixture for fixing the wire, and use the cutter to cut and process the suture with molded barbs, thereby reducing the strength and increasing the elasticity, so as to achieve the overall operation of the suture Sexual and functional best properties.
  • the cutting described in the present application comprises the following steps:
  • the knife cuts the suture, the cutting angle between the knife and the thread body is between 15° and 90°, the cutting position is on the suture body between the molded barbs, and rotates along the thread body to produce a helically arranged cutting modification.
  • the suture of the present application may further comprise a coating to provide the desired property or function or therapeutic effect of the suture.
  • the suture body is a biocompatible material; more preferably, it can be a bioabsorbable material.
  • examples of the material of the thread body include but are not limited to: polylactic acid (PLA), polycaprolactone (PCL), polyhydroxyalkanoate (PHA), polyglycolide (PGA), lactide Ester (LA), polydioxanone thread (PDS), polydioxanone (PPDO), lactic acid-glycolic acid copolymer (Poly(Lactic Acid-co-Glycolic Acid)) (PLGA) , or a combination thereof.
  • the filament is polydioxanone (PPDO).
  • the coating is selected from the group consisting of vitamin C, vitamin E, collagen, hyaluronic acid, and combinations thereof.
  • another embodiment of the coating is an antibiotic.
  • the bioabsorbable material is selected from the group consisting of bioceramics such as calcium carbonate, tricalcium phosphate, calcium sulfate, and combinations thereof.
  • the bioabsorbable material is selected from the group consisting of polymer materials such as collagen, starch, cellulose, gelatin, chitin, hyaluronic acid, and combinations thereof.
  • the surgical suture has a molded barb structure
  • the tissue is pulled closer by the barb-like structure, so that it does not need to be knotted when it is used for wound suturing, but after about 4 weeks after the suture is placed in the body, Its tensile strength is reduced by 50%.
  • the number of molded barbs can be increased.
  • the problem of reduced tensile strength of the suture caused by reducing the number of molded barbs can be improved by cutting and modifying, and by improving the elasticity of the suture, the problem of raised tissue surface can also be improved.
  • the length of the barb 20 is less than 5 mm; in a more preferred embodiment, the length of the barb 20 is equal to or less than 1 mm.
  • the suture 10 has a suture unit a, and the suture unit a is 10mm; each suture unit a includes 4 pairs of molded barbs 20 .
  • the distance between each pair of molded barbs is 2.5 mm; the length of the barbs 20 may be equal to or less than 1 mm.
  • the suture 10 has a suture unit a, the suture unit a is 10 mm in length; each suture unit a includes 2 pairs of molded barbs 20 .
  • the distance between each pair of molded barbs is 10 mm; the length of the barbs 20 may be equal to or less than 1 mm.
  • the problem of surface protrusion is improved due to the reduction of barbs, but the tensile strength is reduced, and the clinical application of wound suture is limited due to insufficient tension.
  • the suture unit a has 2 pairs of molded barbs 202, the length of each suture unit a is 10 mm, the molded barbs 202 of the suture unit a extend toward each other, and the two adjacent sutures Between the units a, the barbs 20 provided in each suture unit a are arranged in the same direction, so only one pair of barbs 20 can be observed in the sectional view of BB'.
  • each suture unit a has a pair of barbs 202 ( FIG. 3 ); in this embodiment, there are multiple cutting modifications 204 between the two pairs of molded barbs 202 of each suture unit a, and the number can be adjusted. Between 2 and 6, the present embodiment is 5.
  • the distance between adjacent cutting modifications 204 is about 0.1-10mm; in a preferred embodiment, the distance is about 0.5-7.5mm; in a preferred embodiment, the distance between adjacent barbs 20 is about 1- 5mm; the spacing between each cutting modification can be the same or different.
  • the cleavage modifications 204 form an included angle ⁇ with each other, and the included angle ⁇ between any two adjacent cleavage modifications 204 is the same and arranged in helical symmetry.
  • the included angle ⁇ may be between 0o-180o, preferably between 15o-90o, more preferably between 30o-90o.
  • the paired molded barbs 202 and the cut modifications 204 are substantially arranged in a rotationally symmetrical manner, and there are two pairs of molded barbs 202 in the suture unit a, during which there are Cleavage modification 204, the number of cleavage modification 204 is 6, and ⁇ is 45°.
  • the length of the cutting modifications 204 may be 0.5-1 mm, preferably 0.6-0.9 mm, more preferably 0.61-0.7 mm.
  • the surgical suture provided by the present application solves the problem of raised tissue surface due to the lack of elasticity of the current molded barbed surgical suture, and at the same time provides considerable grip, greatly improving the overall properties of the surgical suture .

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  • Life Sciences & Earth Sciences (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
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Abstract

一种具改良性质的外科手术缝线（10），包括多个缝线单元（a），其中各缝线单元（a）具有至少二对模塑倒刺（20、202）和多个切割修饰（204），其中每对模塑倒刺（20、202）的二模塑倒刺（20、202）彼此朝相对的方向延伸，该多个切割修饰（204）位于该二对模塑倒刺（20、202）之间；且该切割修饰（204）与另一相邻的切割修饰（204）间相对于缝线轴具有一夹角δ，δ为介于0°-180°。

Description

具改良性质的外科手术缝线 技术领域
本申请涉及一种具增强拉力又不会产生组织表面凸起的外科手术缝线。
背景技术
外科手术缝线为加强拉力，会手术缝线增加模塑倒刺，常用于腹腔镜微创手术的伤口缝合，因缝线的模塑倒刺构造可将伤口两边的组织拉近，免去打结的需求，且缝线本身的抗拉强度可维持伤口的闭合，为目前广泛使用的外科手术缝线。
但市售具模塑倒刺的缝线虽因缝在线倒刺提高对于组织的抓力，但因弹性不足，使用时却会对组织表面，例如皮肤表皮，产生凸起的问题。
针对以上问题，亟需具改善组织表面凸起的外科手术缝线。
发明内容
为解决上述的问题，本申请提供一种具改良性质的外科手术缝线，包括多个缝线单元，其中各缝线单元具有至少二对模塑倒刺和多个切割修饰，其中每对模塑倒刺的二模塑倒刺彼此朝相对的方向延伸，该多个切割修饰位于该2对模塑倒刺之间；且该切割修饰与另一相邻的切割修饰间相对于缝线轴具有一夹角δ，δ为介于0°-180°。
于一实施例，该缝线单元的长度等于或小于10mm。
于一实施例，该二对模塑倒刺之间有至少2个切割修饰，例如2-6个。于一特定实施例，该二对模塑倒刺之间有5个切割修饰。
于一实施例，该多个切割修饰呈螺旋对称排列。
于一实施例，该切割修饰与另一相邻的切割修饰间相对于缝线轴具有一夹角δ，δ为介于0°-180°，较佳为介于15°-90°，较佳为介于30°-90°。
于一实施例，其中该该模塑倒刺与该缝线之间具有一锐角θ，θ小于90°，较佳为等于或小于45°，更佳为等于或小于30°。
于一实施例，其中该模塑倒刺20的长度等于或小于5mm，较佳为等于或小于1mm。
于一实施例，其中该缝线单元的长度为等于或小于10mm。
于一实施例，其中各缝线单元具有至少二对成对模塑倒刺以及多个切割修饰，呈螺旋对称排列，且该螺旋切割修饰与另一相邻的螺旋切割之间相对于缝线轴具有一夹角δ，δ为30-90°。其中该二对模塑倒刺之间较佳为有2-6个切割修饰；一特定实施例中，该二对模塑倒刺之间为有5个切割修饰。
附图说明
本申请以下列附图进一步说明：
图1是相关前案的参考例1的示意图。
图2是相关前案的参考例2的示意图。
图3是相关前案的参考例2的剖面图。
图4是本申请的实施例1的示意图。
图5是本申请的实施例1的剖面图。
附图标记说明
10缝线
20模塑倒刺
202模塑倒刺
204切割修饰
a缝线单元
θ锐角
δ夹角
A-A’剖面切线
B-B’剖面切线。
具体实施方式
本申请的技术特征，包含特定特征，是揭示于权利要求书，针对本申请的技术特征，较佳的理解兹配合说明书、依据本申请原理的实施例、和附图将本申请详细说明如下。
本申请说明书及权利要求书中所述的所有技术性及科学用语，除非另有所定义，皆为本申请所属技术领域具有通常知识者可知晓的定义。其中单数用语“一”、“一个”、“该”、或其近似用语，除非另有说明，皆可指涉多于一个对象。本说明书使用的“或”、“以及”、“和”，除非另有说明， 皆指涉“或/和”。此外，用语“包含”、“包括”皆非有所限制的开放式连接词。前述定义仅说明用语定义的指涉而不应解释为对创作目标的限制。
本申请是提供一种具改良性质的外科手术缝线，包括多个缝线单元，其中各缝线单元具有至少2对模塑倒刺和多个切割修饰，其中每对模塑倒刺的二模塑倒刺彼此朝相对的方向延伸，该多个切割修饰位于该2对模塑倒刺之间；且该切割修饰与另一相邻的切割修饰间相对于缝线轴具有一夹角δ，δ为介于0°-180°。
缝线的加工制程上，会利用模塑倒刺提高拉力，以及使用切割增加缝线的弹性。但因切割会损伤线材，因整体缝线损伤，造成线材整体张力强度下降，若张力强度太弱则可能无法维持伤口组织的闭合。而本申请是利用切割技术修饰具有模塑倒刺的外科手术缝线，解决目前有模塑倒刺的外科手术缝线使用时会造成组织表面凸起不平整的问题。
于本申请中，缝线是应用模压制程中通过加热模具及控制在特定温度之下加热并挤压手术缝线的原料，使缝线表面形塑成倒刺状结构的手段，通过一组或多组滚轮模具形成单一或多种形态的倒刺在同一段缝线的表面。制成有模塑倒刺的缝线，接着再利用切割制程，在前述已经经过模压成形的缝线之上进行切割修饰。
本申请之一具体实施例，是使用切割加工所需的刀具模块与固定线材的夹具，利用刀具将具有模塑倒刺的缝在线进行切割加工，因而降低强度并增加弹性，达缝线整体操作性及功能性最佳性质。
于一特定实施例，本申请所述的切割制成包括下列步骤：
刀具切割缝线，刀具与线体的切削角度介于15～90度之间，切割位置在模塑倒刺间的缝线体上，并且沿着线体旋转产生螺旋状排列的切割修饰。
本申请的缝线可进一步包含一涂层，提供缝线所欲的性质或功能或疗效。
根据本发明，该缝线本体为一生物相容材料；更佳地，可为生物可吸收材料。
于一特定实施例，该线体的材料例示包括但不限于：聚乳酸(PLA)、聚己内酯(PCL)、聚羟基脂肪酸酯(PHA)、聚乙交酯(PGA)、丙交酯(LA)、聚二氧六环酮线(PDS)、聚对二氧环已酮(PPDO)、乳酸-甘醇酸共聚合物(Poly(Lactic Acid-co-Glycolic Acid))(PLGA)，或彼等的组合物。于一较佳实 施例，该线体为聚对二氧环已酮(PPDO)。
于一特定实施例，该涂层是选自由以下组织群：维生素C、维生素E、胶原蛋白、玻尿酸，和彼等的组合物。于一较佳实施例，该涂层的另一实施例为抗生素。
于一特定实施例，生物可吸收材料是选自生物陶瓷类如碳酸钙、三钙磷酸盐、硫酸钙、及其组合所构成的群组。于另一特定实施例，生物可吸收材料是选自高分子聚合物材料如胶原蛋白、淀粉、纤维素、明胶、甲壳素、玻尿酸、及其组合所构成的群组。
根据本申请，因外科手术缝线带有模塑倒刺结构，通过倒刺状结构将组织拉近，使之用于伤口缝合时不须打结，但缝线置于体内约4周后，其抗拉强度即下降50％，为加强拉力强度，可增加模塑倒刺的数量。但使用时却会造成组织表面凸起的问题。于本申请，减少模塑倒刺数量造成的缝线抗拉强度降低的问题，可通过切割修饰改善，又因提高缝线的弹性，同时改善组织表面凸起的问题。
如图3所示实施例1的外科手术缝线，该倒刺20的长度小于5mm；于一更佳实施例，该倒刺20的长度等于或小于1mm。
参照图1所示前案的参考例1的外科手术缝线，该缝线10具有一缝线单元a，该缝线单元a为10mm；各缝线单元a中包括4对模塑倒刺20。每对模塑倒刺距离2.5mm；倒刺20的长度可为等于或小于1mm。该模塑倒刺20与该缝线10之间具有一锐角θ，等于或小于45o。因线材主体与倒刺多而坚硬，拉力强度较强，但使用时却会对组织表面造成凸起。
参照图2，是提供前案的参考例2，该缝线10沿A-A’的剖面图可如图3所示。该缝线10具有一缝线单元a，该缝线单元a为10mm；各缝线单元a中包括2对模塑倒刺20。每对模塑倒刺距离10mm；倒刺20的长度可为等于或小于1mm。该模塑倒刺20与该缝线10之间具有一锐角θ，等于或小于45o。因倒刺减少而改善表面凸起问题，但拉力强度降低，因拉力不足而临床上伤口缝合的应用受限。
如图4所示，为本申请缝线10的具体实施例，该缝线10沿B-B’的剖面图可如图5所示。缝线单元a具有2对模塑倒刺202，各缝线单元a的长度为10mm，该缝线单元a具有的模塑倒刺202是朝彼此相对的方向延伸，彼此相邻的二缝线单元a之间，各缝线单元a所设置的倒刺20是朝相同方 向配置，因此于B-B’的剖面图中，仅可观察到一对倒刺20。
于实施例1，各缝线单元a具有一对倒刺202(图3)；于本实施例，各缝线单元a的该2对模塑倒刺202间有多个切割修饰204，数量可介于2至6，本实施例为5个。相邻的切割修饰204之间彼此相距约0.1-10mm；于一较佳实施例，为相距约0.5-7.5mm；于一较佳实施例，相邻的倒刺20之间彼此相距约1-5mm；各切割修饰之间的间距可为相同或相异。
自B-B’的剖面图观看，该切割修饰204彼此呈一夹角δ，并且任相邻二切割修饰204之间的夹角δ均相同以螺旋对称排列。换言之，各切割修饰与另一相邻的切割修饰之间相对于缝线轴具有一夹角δ。夹角δ可为介于0o-180o，较佳为介于15o-90o，更佳为介于30o-90o。
因此，自B-B’的剖面图观看，该成对模塑倒刺202以及该些切割修饰204实质上是呈旋转对称排列，缝线单元a中有二对模塑倒刺202，期间有切割修饰204，切割修饰204的数量为6，且δ为45o。
实施例1中，该些切割修饰204的长度可为0.5-1mm，较佳地为0.6-0.9mm，更佳地为0.61-0.7mm。
比较参考例1、参考例2、和实施例1的外科手术缝线的性质，其对人体组织抓力以及造成表面凸起程度比较如下表1所示(以分数1-10评分，10表示最佳，1表示最低)：
表1
Figure PCTCN2021107661-appb-000001
如上比较，本申请提供的外科手术缝线解决了目前模塑倒刺外科手术缝 线因不具弹性造成组织表面凸起的问题，同时提供相当的抓力，大大改善了外科手术缝线的整体性质。
于本说明书实施例揭示的内容，本申请所属领域具有通常知识者可明显得知前述实施例仅为例示而非限制；具本申请所属技术领域通常知识者可通过诸多变换、替换而实施，并不与本申请的技术特征有所差异。依据说明书实施例，本申请可有多种变换仍无碍于实施。在不冲突的情况下，各实施例的教示可彼此组合。本说明书提供的权利要求界定本申请的范围，该范围涵盖前述方法与结构及与其相等的创作。

Claims (21)

  1. 一种具改良性质的外科手术缝线，包括多个缝线单元，其中各缝线单元具有至少二对模塑倒刺和多个切割修饰，其中每对模塑倒刺的二模塑倒刺彼此朝相对的方向延伸，该多个切割修饰位于该二对模塑倒刺之间；且该切割修饰与另一相邻的切割修饰间相对于缝线轴具有一夹角δ，δ为介于0°-180°。
  2. 如权利要求1所述的外科手术缝线，其中该缝线单元的长度等于或小于10mm。
  3. 如权利要求1所述的外科手术缝线，其中该二对模塑倒刺之间有至少2个切割修饰。
  4. 如权利要求3所述的外科手术缝线，其中该二对模塑倒刺之间有2-6个切割修饰。
  5. 如权利要求4所述的外科手术缝线，其中该二对模塑倒刺之间有5个切割修饰。
  6. 如权利要求3所述的外科手术缝线，其中该多个切割修饰呈螺旋对称排列。
  7. 如权利要求1所述的外科手术缝线，其中该夹角δ为介于15°-90°。
  8. 如权利要求3所述的外科手术缝线，其中该夹角δ为介于30°-90°。
  9. 如权利要求1所述的外科手术缝线，其中该模塑倒刺与该缝线的间具有一锐角θ，θ小于90°。
  10. 如权利要求9所述的外科手术缝线，其中该锐角θ等于或小于45°。
  11. 如权利要求10所述的外科手术缝线，其中该锐角θ等于或小于30°。
  12. 如权利要求1所述的外科手术缝线，其中该模塑倒刺的长度等于或小于5mm。
  13. 如权利要求12所述的外科手术缝线，其中该模塑倒刺的长度等于 或小于1mm。
  14. 如权利要求1所述的外科手术缝线，其中各缝线单元具有至少二对成对模塑倒刺以及多个切割修饰，呈螺旋对称排列，且该螺旋切割修饰与另一相邻的螺旋切割之间相对于缝线轴具有一夹角δ，δ为30-90°。
  15. 如权利要求13所述的外科手术缝线，其中该二对模塑倒刺的间有2-6个切割修饰。
  16. 如权利要求13所述的外科手术缝线，其中该二对模塑倒刺的间有5个切割修饰。
  17. 如权利要求1所述的外科手术缝线，其进一步包含一涂层。
  18. 如权利要求1所述的外科手术缝线，其中该缝线本体为一生物兼容材料。
  19. 如权利要求1所述的外科手术缝线，其中该缝线本体为一生物可吸收材料。
  20. 如权利要求17所述的外科手术缝线，其中该涂层是选自由以下组织群：维生素C、维生素E、胶原蛋白、玻尿酸，和彼等的组合物。
  21. 如权利要求17所述的外科手术缝线，其中该涂层是抗生素。
PCT/CN2021/107661 2021-07-21 2021-07-21 具改良性质的外科手术缝线 WO2023000210A1 (zh)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000051658A1 (fr) * 1999-03-03 2000-09-08 Marlen Andreevich Sulamanidze Fil chirurgical pour operations de chirurgie plastique
CN1547455A (zh) * 2001-08-31 2004-11-17 ������ҩ��ҵ���޹�˾ 在缝合线上形成倒刺的方法及实施该方法的装置
CN1830200A (zh) * 2002-09-30 2006-09-06 奎尔医疗公司 结合手术针的有倒钩的缝合物
CN101243984A (zh) * 2006-09-06 2008-08-20 Tyco医疗健康集团 带刺缝线中的生物活性物质
KR101432497B1 (ko) * 2013-09-27 2014-08-25 유원석 고착형 미늘 봉합사
US20180177505A1 (en) * 2016-12-28 2018-06-28 Jack Chu Barbed suture

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000051658A1 (fr) * 1999-03-03 2000-09-08 Marlen Andreevich Sulamanidze Fil chirurgical pour operations de chirurgie plastique
CN1547455A (zh) * 2001-08-31 2004-11-17 ������ҩ��ҵ���޹�˾ 在缝合线上形成倒刺的方法及实施该方法的装置
CN1830200A (zh) * 2002-09-30 2006-09-06 奎尔医疗公司 结合手术针的有倒钩的缝合物
CN101243984A (zh) * 2006-09-06 2008-08-20 Tyco医疗健康集团 带刺缝线中的生物活性物质
KR101432497B1 (ko) * 2013-09-27 2014-08-25 유원석 고착형 미늘 봉합사
US20180177505A1 (en) * 2016-12-28 2018-06-28 Jack Chu Barbed suture

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