WO2022260206A1

WO2022260206A1 - Biodegradable egg tray having antiviral performance

Info

Publication number: WO2022260206A1
Application number: PCT/KR2021/008132
Authority: WO
Inventors: 정종구; 홍정혁; 김진우; 우성호
Original assignee: 주식회사 비지에프에코바이오; 케이비에프(주)
Priority date: 2020-08-13
Filing date: 2021-06-29
Publication date: 2022-12-15
Also published as: KR20220021402A; KR102641141B1

Abstract

The present invention relates to a biodegradable egg tray having antiviral performance. The present invention relates to an egg tray including: a base plate having one or more concave egg tray recesses arranged to accommodate eggs; and a detachable lid for covering the entire egg tray recesses in the base plate or an integrated lid connected to the base plate and configured to cover the entire egg tray recesses in the base plate. The base plate or the base plate and the lid are formed of a biodegradable sheet prepared by dispersing composite particles in a raw material resin to a particle size of 100 to 900 nm, the composite particles being obtained by aggregating inorganic antiviral agents alone or two or more types thereof, the raw material resin being selected from: a biodegradable polymer resin formed of polylactic acid-based polymer; or a composite degradable polymer resin formed of a biodegradable resin and a petrochemical resin. Accordingly, the present invention can provide an egg tray having excellent antiviral performance.

Description

Biodegradable egg yolk with antiviral properties

The present invention relates to a biodegradable egg seat having antiviral properties, and more particularly, a bottom plate in which one or more concave egg seat grooves are arranged to accommodate eggs, and a detachable lid covering the entire egg seat groove of the bottom plate or the above An egg seat composed of an integral lid connected to the bottom plate and covering the entire egg seat groove of the bottom plate, wherein the base plate or the base plate and the lid are biodegradable polymer resins made of polylactic acid-based polymer; Or a composite degradable polymer resin composed of a biodegradable resin and a petrochemical resin; a biodegradable sheet prepared by dispersing an inorganic antiviral agent alone or two or more agglomerated composite particles in a particle size of 100 to 900 nm in a raw material resin selected from It relates to a biodegradable egg egg locus having excellent antiviral performance.

In general, eggs are the most easily ingested protein source and provide not only choline, but also various nutrients such as riboflavin (vitamin B2), vitamin B12, biotin (B7), pantothenic acid (B5), iodine, and selenium to promote muscle and bone health, It helps with brain development, so it is a favorite food ingredient for infants and young children, as well as growing children, regardless of generation.

Due to these advantages, eggs are packaged in small packages for snacks and sold at convenience stores, etc., to types that are provided in 10 or more plates at home, and their materials are also provided in a variety of ways, from transparent to opaque.

A typical egg carton is a form in which thick paper is molded or paper pulp is pressed and molded to accommodate eggs, and is formed with a concave portion and a convex portion capable of accommodating eggs. The convex portion formed around the four sides of the portion supports the stored egg. However, in the above method, when a large amount of egg cartons containing eggs are loaded, the concave part of the upper egg carton is located in the convex part of the lower egg carton, and the eggs are exposed to the outside. When loading or transporting a large amount of egg cartons, there is a problem that the eggs are easily damaged due to impact.

However, egg cartons manufactured by dissociating pulp using the paper or pulp mold have disadvantages in that strength is lowered when exposed to moisture, mold easily inhabits, and that fluorescent materials may be contained in the case of recycled pulp.

In particular, in the case of an egg carton manufactured by dissociating the pulp, once the paper or pulp is contaminated with bacteria or the like, it is very difficult to sterilize it.

According to Non-Patent Document 1, when office paper is infected with several species of bacteria, as a result of an experiment on how long it survives, it stably survives on paper for more than 72 hours, and even though there is a low probability, from human hands to paper or from paper back to humans. It is reported that it is delivered by hand. In particular, unlike other materials, it is pointed out that once infected, paper is difficult to remove with chemical agents.

In addition, the egg shell has a cuticle membrane, and this membrane serves to prevent bacterial penetration. However, washing the egg causes another problem in that the cuticle membrane is removed or damaged, making it easier for bacteria to penetrate. That is, pores in egg shells are 10 to 30 μm in size, and bacteria and smaller viruses can easily penetrate and infect eggs with pores of this size.

In order to solve this problem, a method of using an egg carton in which an egg seat groove and a lid are integrally formed with a synthetic resin material (polystyrene foam sheet, non-foaming transparent sheet, non-foaming PP sheet, etc.) has been used.

However, this still does not solve the problem that the egg is easily damaged due to the thin thickness of the synthetic resin, and it does not rot well and acts as a major cause of environmental pollution, so another problem emerges. That is, most of the existing egg yolk seats made of synthetic resin are not eco-friendly products, and in particular, if they are made using recycled resin, the possibility of contamination of foreign substances such as heavy metals cannot be completely eliminated.

Since the 2000s, due to the outbreak of epidemics such as SARS and swine flu, interest in harmful microorganisms for preventing bacterial and viral infections has increased, and steady research has been conducted.

In particular, in a situation where the spread of coronavirus (COVID-19) infection does not subside, along with virus vaccine research, development of products with antiviral performance is required along with life quarantine due to the nature of the virus infected by contact.

Among them, if antiviral performance is given to the egg ovary, concerns about viruses can be eliminated or minimized while conventional egg packaging, so it is hygienic, there is no additional cost in the packaging process, and ultimately stable distribution without shrinking egg consumption By continuing, it will help not only people's lives, but also poultry farms.

In general, microorganisms are life forms that always exist around us. There are beneficial microorganisms that are helpful to humans, but some pathogenic microorganisms such as bacteria, harmful fungi, and viruses cause food spoilage, disease, and odor. causing harm to the human body.

At the end of the 19th century, the possibility of a virus had already been suggested, but the existence of a virus was confirmed in the 1930s, because the virus is too small. In general, the average cell size of humans is about 20 to 100 μm, and bacteria are smaller than this, about 1 to 10 μm. The minimum size that can be distinguished with the naked eye is about 0.1 mm, although it is slightly different for each person, so it is impossible to see bacteria with the naked eye, but the presence of bacteria can be sufficiently confirmed using an optical microscope.

However, since the average size of viruses is much smaller, about 10 to 300 nm, they cannot be observed with an optical microscope with a maximum magnification of only 1,000 times. Therefore, the existence of the virus became possible only after the development of an electron microscope with much higher magnification (maximum magnification of 1,000,000 times).

A virus is an entity with characteristics of both living and non-living things, and is basically a simple structure containing a nucleic acid (DNA or RNA), a genetic material, in an envelope composed of proteins.

Therefore, unlike bacteria, viruses cannot metabolize on their own and thus cannot perform life activities. However, when introduced into host cells, viruses become parasitic in the host cell's life activity process, replicating genetic material and protein coats to multiply the population. let it

When viruses that exist in the form of protein crystals meet a host cell, they combine with the cell membrane of the host cell and enter the interior. After entering the host cell, the virus creates its own genetic material and protein coat using the host cell's genetic material replication function and protein production function, and then reassembles them to proliferate virus cells that resemble itself.

Recently, outbreaks caused by various viruses such as SARS, bird flu, and mass food poisoning are rapidly increasing, and the market demand for personal products or disposable products with antiviral performance is urgent due to the spread of coronavirus (COVID-19) infection. .

Patent Document 1 is an invention related to silver nano antibacterial plastic pellets, in which silver nano in a colloidal state is mixed with pellet-type plastic raw materials (referring to PE, PP, PVC, ABS, AS, PS, etc.) at a certain ratio to form pellets After molding the master batch, the raw material of the plastic product and the master batch are mixed in a certain ratio by the silver nano coating layer formed on the surface of the master batch to re-form the product (for example, plastic film, sheet, molded product, etc.) , it is disclosed that the antibacterial effect is exerted on the surface and material of plastic products.

However, in the prior art, antibacterial and antiviral effects are proposed in combination without distinction. In particular, in the case of the above invention, a method is disclosed in which silver nanoparticles in a colloidal state are prepared in the form of pellets, put together and molded to coat the surface of the pellets with silver, but the particle size in the colloidal state is on the order of 20 to 50nm.

On the other hand, according to Non-Patent Document 2, there is a report on the threatening effect of silver ions or silver nanoparticles on the environment and human health. Silver nanoparticles are useful as antibacterial substances, but in the case of silver nanoparticles at the level of 5 to 50 nm, cells Toxicity is reported.

Based on these reports, a safety problem has been raised because the nano-sized silver nanoparticles can pass through skin gaps (75 nm) and reach organs when applied to the human body, and in fact, Europe (Scientific Committee on Emerging and Newly Identified Health Risks) regulates materials smaller than 100nm as nanomaterials, and in consideration of harm to the human body, at least 50% of the particles are regulated to use particles larger than 100nm.

In non-patent paper 3, it is revealed that coronaviruses survive on various surfaces for tens of hours to 7 days, and that cleaning with traditional disinfection methods returns to the pre-cleaning state within 2.5 hours, so it is only a temporary alternative. Therefore, in order to cope with the proliferation following the attachment and colonization of viruses, research on active surfaces is introduced, and infection-resistant surfaces are proposed through natural, artificial, or biomimetic coatings. As such an approach, nanoparticles including silver, gold, copper, zinc oxide, titanium dioxide, and bionanoparticles such as carbon-based nanotubes and chitosan, despite controversies regarding the cytotoxicity and biocompatibility of nanoparticles to human cells. It is predicted that the use of particles will be effective by significantly increasing the contact area with microorganisms by viruses of 1-10 nm size.

Therefore, as a result of a close examination of the conventional problems and necessity, the inventors of the present invention have found that a base plate in which one or more concave egg seat grooves are arranged to accommodate eggs and a detachable lid covering the entire egg seat groove of the base plate or connected to the base plate An egg nest composed of an integral lid covering the entire egg nest groove of the bottom plate, wherein the base plate or the base plate and the lid are made of a polylactic acid-based polymer; a biodegradable polymer resin; Or a composite degradable polymer resin composed of a biodegradable resin and a petrochemical resin; a biodegradable sheet prepared by dispersing an inorganic antiviral agent alone or two or more agglomerated composite particles in a particle size of 100 to 900 nm in a raw material resin selected from By providing an egg locus composed of egg locus, the inorganic antiviral agent prevents skin penetration by controlling the particle size of the inorganic antiviral agent, and at the same time, the inorganic antiviral agent inactivates the virus before entering the human body by contact with an external virus or RNA replicates even if infected By inhibiting it to confirm the implementation of antiviral performance, the present invention was completed.

(Patent Document 1) Korean Patent No. 0854730 (published on August 27, 2008)

(Non-Patent Document 1) "Survival of Bacterial Pathogens on Paper and Bacterial Retrieval from Paper to Hands: Preliminary Results." , Am. J Nurs., 2011, 111(12), 30-34.

(Non-Patent Document 2) "Silver or silver nanoparticles: a hazardous threat to the environment and human health", J. Appl. Biomed., 2008, 6, 117-129.

(Non-Patent Document 3) "A critical evaluation of current protocols for self-sterilizing surfaces designed to reduce viral nosocomial infections", Am. J. Infect. Control, 2020, 48, P1255-1260.

An object of the present invention is to provide a biodegradable egg locus having antiviral properties.

In order to achieve the above object, the present invention provides a bottom plate in which one or more concave egg seat grooves are arranged to accommodate eggs, and a detachable lid covering the entire egg seat groove of the bottom plate or an egg seat groove of the bottom plate while being connected to the bottom plate. In the egg yolk seat composed of an integral lid covering the whole,

The bottom plate or the base plate and the lid is a biodegradable polymer resin made of polylactic acid-based polymer; or a composite degradable polymer resin composed of a biodegradable resin and a petrochemical resin; composed of a biodegradable sheet prepared by dispersing an inorganic antiviral agent alone or a composite particle in which two or more aggregated composite particles are dispersed to a particle size of 100 to 900 nm in a raw material resin selected from Provided is a biodegradable egg locus having antiviral properties.

The inorganic antiviral agent is used alone or in a mixture of two or more selected from the group consisting of silver nanoparticle complexes, silver ion-containing nanocomposites, copper monovalent compounds, zinc oxide nanoparticles and ferrite nanoparticles.

In the above, the silver nanoparticle composite or the silver ion-containing nanocomposite is any one selected from the group consisting of minerals including silica (SiO ₂ ), alumina, zeolite, sericite mordenite, cristobalite and bentonite, talc, cellulose derivatives, paraffin and wax It is preferable that silver nanoparticles or silver ion-containing nanoparticles are adsorbed or bonded to.

In the above, the ferrite nanoparticles are alpha-ferrite (α-Fe ₂ O ₃ ), zinc ferrite (ZnFe ₂ O ₄ ), manganese ferrite (MnFe ₂ O ₄ ), nickel ferrite (NiFe ₂ O ₄ ) and iron hydroxide (α -FeOOH) is a combination of one or more selected from the group consisting of.

The biodegradable egg locus having antiviral properties of the present invention contains 0.1 to 60 parts by weight of an inorganic antiviral agent based on 100 parts by weight of the biodegradable or composite degradable polymer resin.

In addition, the biodegradable sheet of the present invention uses a biodegradable polymer resin composed of a polylactic acid polymer or a composite degradable polymer resin composed of a biodegradable resin and a petrochemical resin as a raw material resin. Polylactic acid (PLA), polyhydroxyalkanoates (PHA), polybutylene adipate-co-terephthalate (PBAT), polybutylene succinate -co-adipate (PBSA), polybutylene succinate-co-terephthalate (PBSAT), polybutylene succinate (PBS), polyvinyl alcohol, PVA), poly glycolic acid (PGA), poly lactic-co-glycolic acid (PLGA) and polycaprolactone (PCL), modified starch resin and thermoplastic starch ( thermoplastic starch, TPS) alone or in a mixture of two or more.

In the biodegradable egg seat having antiviral performance of the present invention, the base plate or the base plate and the lid may include a transparent polylactic acid (PLA) non-foaming sheet; Opaque PLA non-foam sheet; An extruded foam sheet made of a PLA-based polymer; And a multi-layer sheet in which a non-foaming sheet made of a biodegradable polymer resin or a petrochemical resin made of a polylactic acid polymer is laminated on at least one surface of the extruded foam sheet, and is made of any one material selected from the group consisting of The base plate and lid can be combined with the same seat material or different seat materials.

In the above, the non-foam sheet may be laminated to the inner surface of the base plate made of an extruded foam sheet or to the outer surface of the base plate.

At this time, the non-foaming sheet preferably contains 0.1 to 60 parts by weight of an inorganic antiviral agent based on 100 parts by weight of the biodegradable polymer resin or petrochemical resin, and the thickness of the non-foaming sheet is 50 to 500 μm.

In addition, the biodegradable egg nest having antiviral performance of the present invention includes a bottom plate or a bottom plate and a lid of a transparent polylactic acid (PLA) non-foaming sheet; Opaque PLA non-foam sheet; An extruded foam sheet made of a PLA-based polymer; And on at least one side of the extruded foam sheet, a multi-layer sheet in which a non-foam sheet made of a biodegradable polymer resin or a petrochemical resin made of a polylactic acid polymer is laminated on at least one side of the extruded foam sheet.

It may include a form in which an inorganic antiviral active layer is formed by applying an active layer solution including a single or mixed form selected from inorganic antiviral agents and dispersants.

The inorganic antiviral active layer is formed by a coating method or a spray method using a mist nozzle, characterized in that the inorganic antiviral agent is dispersed and coated at 0.01 to 5 g / m 2 .

In the biodegradable egg yolk having antiviral properties of the present invention, the dispersing agent is to use any one selected from the group consisting of polyethylene glycol (PEG), citric acid, lactic acid and polylactic acid (PLA).

The biodegradable egg ovary having the above antiviral performance has excellent antiviral properties against at least one selected from the group consisting of filine coronavirus (fCoV), influenza A virus (FluA), avian influenza (AI) virus, and swine virus. implement

Furthermore, the present invention relates to 100 parts by weight of an organic solvent, 0.1 to 20 parts by weight of an inorganic antiviral agent and 0.1 to 20 parts by weight of a dispersant selected from the group consisting of polyethylene glycol (PEG), citric acid, lactic acid and polylactic acid (PLA), alone or in a mixed form. Provides a coating composition having antiviral performance containing 20 parts by weight.

The inorganic antiviral agent is a single form or a mixture of two or more selected from the group consisting of a silver nanoparticle complex, a silver ion-containing nanocomposite, a copper monovalent compound, zinc oxide nanoparticles and ferrite nanoparticles, wherein the silver nanoparticle complex or silver ion Silver nanoparticles or nanoparticles containing silver ions are selected from the group consisting of silica (SiO ₂ ), alumina, zeolite, mordenite, cristobalite, and bentonite-containing nanocomposites, minerals including talc, cellulose derivatives, paraffin, and wax. adsorbed or bound.

In addition, the organic solvent is tetrahydrofuran (THF), chlorinated organic solvents including chloroform, acetonitrile, dioxane and dimethylformamide (DMF), dimethylacetamide (DMAc), ethanol, methanol, normal-propyl alcohol or iso -Alcohols selected from propyl alcohol; At least one from the group consisting of chlorinated organic solvents including chloroform, benzene, toluene, acetonitrile and dioxane is used.

According to the present invention, it is possible to provide a biodegradable egg yolk locus having antiviral properties.

The egg yolk seat of the present invention is a biodegradable polymer resin made of a polylactic acid-based polymer; Or a composite degradable polymer resin composed of a biodegradable resin and a petrochemical resin; composed of a biodegradable sheet prepared by dispersing inorganic antiviral agents alone or composite particles aggregated with two or more at a particle size of 100 to 900 nm in a raw material resin selected from Accordingly, skin penetration is prevented by controlling the particle size of the inorganic antiviral agent, and at the same time, the inorganic antiviral agent inactivates the virus before entering the human body by contact with the virus or inhibits RNA replication even after infection, An egg ovary having excellent antiviral performance can be provided.

The biodegradable egg yolk seat having antiviral performance of the present invention can meet the market demand for various viruses such as SARS, bird flu, mass food poisoning, and coronavirus (COVID-19) infection.

1 is a schematic diagram of a cross-section of a biodegradable non-foaming sheet having antiviral properties for producing egg nests of the present invention;

2 is a schematic diagram of a cross-section of a biodegradable foam sheet having antiviral properties for producing egg yolks of the present invention;

3 is a schematic diagram of a cross-section of a biodegradable sheet having antiviral properties for producing egg egg nests of the present invention;

4 is a schematic diagram of a cross-section of a biodegradable sheet having antiviral properties for producing egg egg nests of the present invention;

5 is a cross-sectional photograph of a PLA (nZnO) biodegradable sheet incorporating ZnO prepared in Example 1 of the present invention;

6 is a cross-sectional photograph of a PLA (CuZn) biodegradable sheet incorporating ZnO/CuI prepared in Example 2 of the present invention;

7 is a cross-section of a PLA (AgNP) biodegradable sheet incorporating silver nanoparticle complexes prepared in Example 3 of the present invention;

8 is a cross-section of a PLA (CuI) biodegradable sheet incorporating CuI prepared in Example 4 of the present invention;

9 is a cross-section of a biodegradable PLA (nZnAgCu) sheet incorporating ZnO/silver nanoparticle composites/CuI prepared in Example 5 of the present invention;

10 is another embodiment of the biodegradable sheet having antiviral properties for egg egg locus production of the present invention, which is a schematic cross-sectional view of a sheet formed with an inorganic antiviral active layer containing one inorganic antiviral agent,

11 is a schematic cross-sectional view of a sheet formed with an inorganic antiviral active layer containing two inorganic antiviral agents in FIG. 10;

12 is a schematic cross-sectional view of a sheet as another embodiment of the biodegradable sheet having antiviral properties for producing egg egg locus according to the present invention;

FIG. 13 is a schematic cross-sectional view of a sheet of another embodiment of the biodegradable sheet having antiviral properties for egg egg locus production of FIG. 12 .

Hereinafter, the present invention will be described in detail.

The present invention consists of a bottom plate in which one or more concave egg seat grooves are arranged to accommodate eggs, a detachable lid covering the entire egg seat groove of the bottom plate, or an integral lid connected to the bottom plate and covering the entire egg seat groove of the bottom plate. In the egg yolk seat, the bottom plate or the bottom plate and the lid is a biodegradable polymer resin made of polylactic acid-based polymer; or a composite degradable polymer resin composed of a biodegradable resin and a petrochemical resin; composed of a biodegradable sheet prepared by dispersing an inorganic antiviral agent alone or a composite particle in which two or more aggregated composite particles are dispersed to a particle size of 100 to 900 nm in a raw material resin selected from Provided is a biodegradable egg locus having antiviral properties.

In the above, "biodegradable sheet" refers to a biodegradable polymer resin made of a polylactic acid-based polymer; Or a composite degradable polymer resin composed of a biodegradable resin and a petrochemical resin; based on a thickness of 0.254 mm, including single-layer, multi-layer, non-foaming and foaming structures formed by T-die, blown and extrusion foaming using raw material resins of It is collectively referred to as a sheet, including a structure defined as a sheet when the thickness is greater than the above or a film when the thickness is less than the above.

Specifically, in the biodegradable egg nest having antiviral performance of the present invention, the base plate or the base plate and the lid are transparent polylactic acid (Polylactic acid, PLA) non-foaming sheets; Opaque PLA non-foam sheet; An extruded foam sheet made of a PLA-based polymer; And a multi-layer sheet in which a non-foaming sheet made of a biodegradable polymer resin or a petrochemical resin made of a polylactic acid polymer is laminated on at least one surface of the extruded foam sheet, and is made of any one material selected from the group consisting of The base plate and lid can be combined with the same seat material or different seat materials.

As an example, in the form of an egg seat, a bottom plate in which one or more concave egg seat grooves are arranged to accommodate eggs and a detachable lid covering the entire egg seat groove of the bottom plate or an egg seat groove of the bottom plate while being connected to the bottom plate It includes a form composed of an integral lid covering the whole and can be employed without being limited to the form of a conventional egg packaging container.

At this time, the base plate and the lid may be made of a transparent PLA non-foaming sheet.

In addition, when the lid is a transparent PLA non-foaming sheet, the bottom plate is an opaque PLA non-foaming sheet; An extruded foam sheet made of a PLA-based polymer; Or a multilayer sheet in which a non-foaming sheet made of a biodegradable polymer resin or a petrochemical resin made of a polylactic acid-based polymer is laminated on at least one surface of the extruded foam sheet; can be selected from.

As another example, the bottom plate and the lid may be made of an extruded foam sheet made of a PLA-based polymer.

In addition, the bottom plate and the lid may be made of a multilayer sheet in which a non-foaming sheet made of a biodegradable polymer resin or a petrochemical resin made of a polylactic acid polymer is laminated on at least one surface of the extruded foam sheet.

In this case, the non-foaming sheet may be laminated to the inner surface of the base plate made of an extruded foam sheet or to the outer surface of the base plate.

In the above, lamination is not limited to methods such as coating, coating, and co-extrusion, and means that a multi-layer structure is formed using the same.

The biodegradable egg yolk seat having antiviral performance of the present invention is obtained by mixing 0.1 to 60 parts by weight of an inorganic antiviral agent with a base plate or a biodegradable sheet constituting the base plate and lid, and then the inorganic antiviral agent alone or two or more kinds are aggregated on the biodegradable sheet. If the composite particles meet the characteristics of being dispersed with a particle size of 100 to 900 nm, the combination of biodegradable sheet materials can be changed and manufactured according to the price, thickness and strength standards required by the market.

1 is a schematic cross-sectional view of a biodegradable non-foam sheet having antiviral properties for producing egg nests of the present invention, and FIG. 2 is a schematic cross-sectional view of a biodegradable foam sheet having antiviral properties for producing egg egg nests of the present invention, It shows the shape in which the inorganic antiviral agent is incorporated into the sheet.

Figure 3 is a schematic cross-sectional view of a biodegradable sheet having antiviral properties for producing an egg locus of the present invention. On at least one surface of a biodegradable foam base sheet 11, an inorganic antiviral agent composition 31 is applied to a polylactic acid polymer. this distributed The non-foaming sheet 30 is laminated.

FIG. 4 is a schematic view of a cross section of a biodegradable sheet in which an inorganic antiviral agent 21 is further contained in the biodegradable foam base sheet 11 in FIG. 3 .

3 and 4, the non-foam sheet 30 provides antiviral properties by containing 0.1 to 60 parts by weight of an inorganic antiviral agent based on 100 parts by weight of a biodegradable polymer resin or petrochemical resin made of a polylactic acid polymer. while reinforcing the strength of the entire sheet at the same time.

In addition, the non-foaming sheet 30 preferably has a thickness of 50 to 500 μm, and may vary depending on the purpose of use, and the thickness and strength specifications may be changed according to the demand of the consumer of the biodegradable sheet.

10 is another embodiment of the biodegradable sheet having antiviral properties for producing egg nests of the present invention, wherein at least one surface of the biodegradable foam base sheet 11 contains an inorganic antiviral active layer containing one type of inorganic antiviral agent 41 11 is a schematic cross-sectional view of a sheet formed with an inorganic antiviral active layer 40 containing two types of inorganic

antiviral agents

41 and 42 in FIG. 10.

In FIGS. 10 and 11, the foam base sheet 11 was exemplified, but it will not be limited thereto.

12 is another embodiment of the biodegradable sheet having antiviral properties for egg egg locus production of the present invention, which includes a biodegradable non-foaming base sheet 10 and a biodegradable polymer resin or petrochemical resin made of a polylactic acid-based polymer. It is a multilayer sheet in which the non-foaming sheet 50 is laminated, and an inorganic antiviral active layer 40 containing two types of inorganic

antiviral agents

41 and 42 is formed on at least one surface of the multilayer sheet.

13 is a cross-sectional schematic diagram of another embodiment of the antiviral biodegradable sheet of FIG. 12 .

Specifically, in the antiviral biodegradable sheet of FIGS. 12 and 13, the inorganic antiviral active layer (40 ) is formed, and provides strength to the antiviral biodegradable sheet, and the thickness and strength specifications may be changed depending on the purpose of use.

The biodegradable base sheet may be changed to a non-foamed base sheet 10 or a foamed base sheet 11, and in particular, a biodegradable non-foamed sheet 50 on the foamed base sheet 11 shown in FIG. 13 As the inorganic antiviral active layer 40 is formed on the laminated multilayer sheet, it can provide gas barrier properties as well as strength, and can fundamentally prevent virus penetration into the foamed cells of the foam base sheet 11. .

Hereinafter, the characteristics of each component of the biodegradable egg locus having antiviral performance of the present invention will be described in detail.

(1) Raw material resin of biodegradable sheet

The biodegradable polymer resin made of polylactic acid-based polymer as raw material resin may be crystalline polylactic acid alone or a combination of amorphous polylactic acid and crystalline polylactic acid. At this time, in order to realize not only the impact resistance and mold stability of the polylactic acid resin but also the heat resistance stability of the molded article, it can be achieved by adjusting the mixing ratio of the crystalline polylactic acid and the amorphous polylactic acid.

As another raw resin, optimize the material of the composite degradable polymer resin by mixing the petrochemical resin with the biodegradable resin containing the polylactic acid within the scope of meeting the requirements of bio-based plastics in consideration of strength and productivity. A polylactic acid-based polymer composition may be used. Preferably, it is composed of 60 to 99% by weight of a biodegradable resin and 1 to 40% by weight of a petrochemical resin. In this case, the biodegradable resin includes poly L-lactic acid (hereinafter referred to as “PLLA”) and poly D-lactic acid (hereinafter referred to as “PDLA”), and may further include a known biodegradable resin. Preferred biodegradable resins include polyhydroxyalkanoates (PHA), polybutylene adipate-co-terephthalate (PBAT), and polybutylene succinate-co- adipate, PBSA), polybutylene succinate adipate-co-terephthalate (PBSAT), polybutylene succinate (PBS), polyvinyl alcohol (PVA), Poly glycolic acid (PGA), poly lactic-co-glycolic acid (PLGA) and polycaprolactone (PCL), modified starch resin and thermoplastic starch TPS) alone or a mixture of two or more selected from the group consisting of may be further included.

In addition, as the petrochemical resin, any one or a mixture of two or more selected from thermoplastic resins of polystyrene, polyethylene, polypropylene, polyester, polycarbonate, acrylic resin, ethylene vinyl acetate resin, polyvinyl alcohol or polyvinyl chloride It is preferable to use one, but if it is a polymer resin other than the polymer resin presented above, the use is not particularly limited. At this time, the petrochemical resin is contained in an amount of 1 to 40% by weight. At this time, if it is less than 1% by weight, the content of the biodegradable polymer resin is increased and the decomposition property is improved, but the improvement in heat resistance is insufficient, and the composite physical properties expected by mixing the petrochemical resin However, on the other hand, if the content of the petrochemical resin exceeds 40% by weight, there is a problem that the carbon dioxide footprint of PLA decreases. The composite degradable polymer resin composition is a biodegradable resin It is possible to extend the useful life by shortening the biodegradation period or improving the color fastness in some cases compared to the case of the single composition.

(2) chain extender

Polylactic acid used in the present invention is brittle due to lack of strength when the molecular weight is low even when well dried, making it difficult to proceed with the subsequent process. For the purpose of increasing the molecular weight of polylactic acid, chain extender ) is used.

Preferable examples of the chain extender used in the present invention include the group consisting of diglycidyl ether, terephthalic acid diglycidyl ether, trimethylolpropane diglycidyl ether and 1,6-hexanediol diglycidyl ether. An epoxy-based compound selected from; Isocyanate-based compounds selected from the group consisting of hexamethylene diisocyanate, tolylene diisocyanate, xylylene diisocyanate, diphenylmethane diisocyanate and triisocyanate; (meth)acrylic compounds; and lauroyl peroxide, benzoyl peroxide, azo-bis-isobutylonitrile, tributyl hydroperoxide, dicumyl peroxide, di-tributylperoxide, 2,5 dimethyl-2,5 di(t-butyl Peroxy) hexane (2,5-Dimethyl-2,5-di (t-butyl peroxy) hexane), 1,3-bis (t-butylperoxy-isopropyl) benzene (1,3-Bis (t- buthyl peroxy-isoproplybenzene) and a peroxide-based compound; to use any one or more than one selected from the group consisting of.

At this time, when the chain extender is used in an amount of 0.05 to 4 parts by weight, more preferably 0.1 to 2 parts by weight, based on 100 parts by weight of the polylactic acid, the effect of improving heat resistance is evident. If the content of the chain extender is less than 0.05 parts by weight, the effect of increasing the molecular weight is insufficient, and it is not easy to prepare it in a sheet form. If it exceeds 4 parts by weight, crystallinity and heat resistance are improved, but excessive molecular weight increase and crosslinking As a result, there is a concern that the extruder die may be clogged, resulting in process problems.

(3) Foaming nucleating agent and foaming agent

In the preparation of the extruded foam sheet among the biodegradable sheets of the present invention, the foam nucleating agent may be an inorganic foam nucleating agent such as talc or silica or an organic foam nucleating agent such as calcium stearate. In particular, the foam nucleating agent may be added in the form of a master batch. In preparing the masterbatch, dispersing agents, stabilizers, antioxidants, UV stabilizers, lubricants, etc. may be further added to control the dispersibility of the foaming nucleating agent and improve processability. In addition, a dispersant may be further added separately instead of adding the dispersant together during preparation of the masterbatch. In this case, stearic acid amide or the like may be used as the dispersant.

The foaming nucleating agent is preferably contained in an amount of 0.01 to 4 parts by weight based on 100 parts by weight of the polylactic acid-based polymer composition. At this time, when the content is too small, less than 0.01 parts by weight, the polylactic acid-based resin particles can be sufficiently foamed. If it exceeds 4 parts by weight, no further function of the foaming nucleating agent can be expected, and there is a concern that the expandability and adhesion properties of the obtained expanded particles during molding in the mold may become insufficient.

Further, on the first extruder, a foaming agent is press-injected together with the polylactic acid-based resin particles and a foaming nucleating agent, and the content of the foaming agent is 1 to 30 parts by weight, preferably 3 to 20 parts by weight. At this time, the foaming agent is selected from the group consisting of propane, isobutane, n-butane and cyclobutane alone or a mixture thereof; Isopentane, n-pentane and cyclopentane alone or a mixture selected from the group consisting of; Isohexane, n-hexane, cyclohexane, trichlorofluoromethane, dichlorodifluoromethane, chlorofluoromethane, trifluoromethane, 1,1,1,2-tetrafluoroethane, 1-chloro-1 , 1-difluoroethane, 1,1-difluoroethane, 1-chloro-1,2,2,2-tetrafluoroethane, nitrogen, carbon dioxide, argon, and physical blowing agents such as air. Among them, physical foaming agents that do not destroy the ozone layer and are inexpensive are preferable, and specifically, nitrogen, air, and carbon dioxide are preferable. Also, carbon dioxide is preferable in that expanded particles having a smaller apparent density can be obtained relative to the amount of the foaming agent used. Also, two or more blowing agents such as carbon dioxide and isobutane may be used in combination.

(4) Inorganic antiviral agent

The inorganic antiviral agent of the present invention is to use one or a mixture of two or more selected from the group consisting of silver nanoparticle complexes, silver ion-containing nanocomposites, copper monovalent compounds, zinc oxide nanoparticles and ferrite nanoparticles.

In the case of silver nanoparticles among the inorganic antiviral agents, activity against bacteria and viruses is known and continuous research is being conducted. However, as a result of research showing activity depending on the particle size, silver nanoparticles with a very small particle size of 5 to 50 nm As problems of skin penetration and toxicity were pointed out, the harmfulness of silver nanoparticles to the human body has been steadily increasing. It is emerging [Non-Patent Document 2].

Therefore, the inorganic antiviral agent of the present invention is one in which inorganic antiviral agents alone or two or more types of agglomerated composite particles are dispersed and included in a particle size of 100 to 900 nm. By controlling the particle size of the inorganic antiviral agent, skin penetration can be prevented, and excellent antiviral properties can be realized by contact with external viruses.

As another method, the present invention uses a composite in the form of a carrier having a three-dimensional skeletal structure with fine pores as an example of supporting the antimicrobial metal component. As a preferred example, silver nanoparticles or nanoparticles containing silver ions are selected from the group consisting of silica (SiO ₂ ), alumina, zeolite, sericite, mordenite, minerals including cristobalite and bentonite, talc, cellulose derivatives, paraffin and wax. Adsorption to either or If it is in the form of a combined complex and can support silver nanoparticles or silver ion-containing nanoparticles, a known carrier may be further included.

At this time, if the particle size of the composite in the form of a support is satisfied with a particle size of 100 to 900 nm, the particle size of the silver nanoparticles or silver ion-containing nanoparticles supported on the support may also include a particle size of 1 to 100 nm. .

As the silver ion-containing nanocomposite of the present invention, the examples are described using silica particles in which silver ions and zinc ions are combined, but it will not be limited thereto.

As another inorganic antiviral agent used in the present invention, copper monovalent compounds are effective in implementing antiviral properties, and CuI, CuCl, Cu ₂ S, Cu ₂ O back desirable.

Although CuI is used as a copper monovalent compound in the embodiment of the present invention, it will not be particularly limited as long as it is an ionic compound bonded to an anion capable of ionic bonding with a copper monovalent cation.

As another inorganic antiviral agent, zinc oxide nanoparticles are metal oxide particles that are harmless to the human body due to their strong antibacterial power and high stability.

In the embodiment of the present invention, when the zinc oxide nanoparticles and the ferrite nanoparticles are in a mixed form, more preferable antiviral performance can be confirmed. In this case, the ferrite nanoparticles include alpha-ferrite (α-Fe ₂ O ₃ ), zinc ferrite (ZnFe ₂ O ₄ ), manganese ferrite (MnFe ₂ O ₄ ), nickel ferrite (NiFe ₂ O ₄ ) and iron hydroxide. At least one selected from the group consisting of (α-FeOOH) is blended.

Specifically, in the inorganic antiviral agent in the form of a mixture of zinc oxide (ZnO) nanoparticles and ferrite nanoparticles used in Examples, the ferrite nanoparticles are alpha-ferrite (α-Fe ₂ O ₃ ), zinc ferrite (ZnFe ₂ O ₄ ) and manganese ferrite (MnFe ₂ O ₄ ) are mixed. However, two or more types of agglomerated composite particles may be variously combined within a range that satisfies the particle size requirements.

The inorganic antiviral agent contained in the biodegradable sheet of the present invention is a biodegradable polymer resin made of a polylactic acid polymer; Or a composite degradable polymer resin made of a biodegradable resin and a petrochemical resin; Based on 100 parts by weight, 0.1 to 60 parts by weight of an inorganic antiviral agent, more preferably 1 to 30 parts by weight is included. At this time, if less than 0.1 parts by weight of the inorganic antiviral agent is contained, the expression of antiviral performance is insufficient, and if the inorganic antiviral agent exceeds 60 parts by weight, the economic efficiency compared to the effect is reduced. This is undesirable because there is a problem of a significant decrease.

Through the above, the present invention prevents skin penetration by controlling the particle size of the inorganic antiviral agent by dispersing the particle size of the inorganic antiviral agent alone or the composite particles in which two or more types are aggregated to be dispersed at 100 to 900 nm, and at the same time preventing the inorganic antiviral agent from penetrating into the skin. A biodegradable egg locus having excellent antiviral performance can be provided by inactivating the virus before entering the human body by contact with the virus or by inhibiting RNA replication even after being infected.

In addition, even if the human body is infected once, in the case of a virus in the form of RNA, nanoparticles of an inorganic antiviral agent are adsorbed to RNA and interfere with replication, thereby realizing antiviral performance.

(5) non-foam sheet

Among the biodegradable sheets of the present invention, a multilayer sheet in which a non-foaming sheet made of a biodegradable polymer resin or a petrochemical resin is laminated on at least one side of an extruded foam sheet made of a PLA-based polymer may be employed.

More preferably, based on 100 parts by weight of a biodegradable polymer resin made of a polylactic acid polymer, 0.05 to 4 parts by weight of a chain extender, 0.01 to 4 foaming nucleating agents selected from the group consisting of talc, silica and calcium stearate On at least one side of the extruded foam sheet in which parts by weight and 1 to 30 parts by weight of a physical foaming agent are mixed and compressed and foamed, a biodegradable polymer resin made of a polylactic acid polymer or a petrochemical resin containing an inorganic antiviral agent containing an inorganic antiviral agent is contained. A non-foaming sheet is laminated.

On at least one side of the extruded foam sheet, a non-foam sheet containing an inorganic antiviral agent is laminated and bonded to a biodegradable polymer resin or petrochemical resin made of a polylactic acid-based polymer, thereby providing strength to the biodegradable sheet. Depending on the thickness and strength specifications can be changed.

At this time, the non-foam sheet preferably has a thickness of 50 to 500 μm. If the thickness of the non-foam sheet is less than 50 μm, there is a problem that the thickness becomes non-uniform in the extrusion lamination process, and if it exceeds 500 μm, the thickness of the foam layer This is undesirable because the cell structure is unstablely changed.

(6) Inorganic antiviral active layer

In addition, the biodegradable egg nest having antiviral performance of the present invention includes a bottom plate or a transparent polylactic acid (PLA) non-foaming sheet; Opaque PLA non-foaming sheet; An extruded foam sheet made of a PLA-based polymer; And on at least one side of the extruded foam sheet, a multi-layer sheet in which a non-foam sheet made of a biodegradable polymer resin or a petrochemical resin made of a polylactic acid polymer is laminated on at least one side of the extruded foam sheet.

An inorganic antiviral active layer may be formed by applying an active layer solution including a single or mixed form selected from inorganic antiviral agents and dispersants.

More preferably, as the inorganic antiviral active layer is formed on the multilayer sheet in which the biodegradable non-foaming sheet 50 is laminated on at least one surface of the extruded foam sheet, it is possible to provide strength as well as gas barrier properties, and the foam base sheet Virus penetration into the foam cell of (11) can be fundamentally prevented.

In the above, the inorganic antiviral agent is the same as described above.

In addition, the dispersant is usually selected from human body stability materials known as food additives and is employed from components compatible with biodegradable raw resins, especially PLA. Preferably, at least one selected from the group consisting of polyethylene glycol (PEG), citric acid, lactic acid and polylactic acid (PLA) use. The polylactic acid (PLA) may be contained as a dispersion medium or vehicle in the undercoat solution.

Since the active layer solution including the single or mixed form selected from the inorganic antiviral agent and dispersant uses a dispersant from a component miscible with PLA, a solvent group capable of dissolving the dispersant and having excellent volatility is used as an alternative. Preferably tetrahydrofuran (THF), chlorinated organic solvents including chloroform, acetonitrile, dioxane and dimethylformamide (DMF), dimethylacetamide (DMAc), ethanol, methanol, normal-propyl alcohol or iso-propyl alcohol Alcohols selected from It is selected from the group consisting of chlorinated organic solvents including chloroform, benzene, toluene, acetonitrile and dioxane, and is dispersed in one or more.

At this time, the inorganic antiviral active layer may be formed by a coating method using an active layer solution or a spray method using a mist nozzle, and the coating method may use a Mayer bar or a gravure bar, and may be employed in a known method. Any known method of applying a liquid phase to one surface will be applicable.

At this time, it is preferable that the inorganic antiviral agent is dispersed at 0.01 to 5 g / m 2, and when the dispersion is less than 0.01 g / m 2, the interval between the inorganic antiviral agents is widened compared to the size of the virus, and the antiviral performance is insufficient. Dispersion exceeding / ㎡ significantly reduces the economic feasibility.

The biodegradable egg locus having virus performance of the present invention has antiviral activity against at least one selected from the group consisting of filine coronavirus (fCoV), influenza A virus (FluA), avian influenza (AI) virus, and swine virus. this is implemented

The inorganic antiviral agent is used alone or in a mixture of two or more selected from the group consisting of the same silver nanoparticle complex, silver ion-containing nanocomposite, copper monovalent compound, zinc oxide nanoparticle and ferrite nanoparticle as described above.

In the above, the silver nanoparticle composite or silver ion-containing nanocomposite is any one selected from the group consisting of silica (SiO ₂ ), alumina, zeolite, sericite, mordenite, cristobalite, and bentonite, minerals including, talc, cellulose derivatives, paraffin, and wax. Any silver nanoparticles or silver ion-containing nanoparticles adsorbed or bound to one may be used.

In addition, the ferrite nanoparticles are alpha-ferrite (α-Fe ₂ O ₃ ), zinc ferrite (ZnFe ₂ O ₄ ), manganese ferrite (MnFe ₂ O ₄ ), nickel ferrite (NiFe ₂ O ₄ ) and iron hydroxide ( At least one selected from the group consisting of α-FeOOH) is blended.

The organic solvent can dissolve the inorganic antiviral agent and the dispersing agent and can be used as an alternative to a solvent group having excellent volatility.

Preferably tetrahydrofuran (THF), chlorinated organic solvents including chloroform, acetonitrile, dioxane and dimethylformamide (DMF), dimethylacetamide (DMAc), ethanol, methanol, normal-propyl alcohol or iso-propyl alcohol Alcohols selected from At least one from the group consisting of chlorinated organic solvents including chloroform, benzene, toluene, acetonitrile and dioxane is used.

In the embodiments of the present invention, 1,4-dioxane and chloroform have been used, but will not be limited thereto.

Hereinafter, the present invention will be described in more detail through examples.

These examples are intended to explain the present invention in more detail, and the scope of the present invention is not limited to these examples.

<실시예 1> <Example 1>

Mix 1 part by weight of ZnO nanoparticles with respect to 100 parts by weight of PLA resin (Total Corbion's Lumini L175), mix well using a general mixer such as a tumbling mixer, and then use a twin-screw extruder with an inner diameter of 65mm to pellet a uniform composition was manufactured. At this time, the sheet was extruded by setting a temperature profile of 260/220/230/230/180/150° C. in the direction of the extrusion die at the hopper inlet. An extruded non-foam sheet was prepared by introducing the pellets into a first extruder having an inner diameter of 90 mm and using a tandem extruder in which a first extruder having an inner diameter of 90 mm and a second extruder having an inner diameter of 120 mm are connected.

The polylactic acid resin particles were supplied to the first extruder, melted and kneaded by heating, and then pushed into the first extruder, where the residence time was maintained for 10 minutes. At this time, the heating and melting temperature was maintained at 170 to 230 ° C. based on the resin temperature. Then, in a second extruder connected to the first extruder, the temperature of the molten mixed reactants was slightly decreased to bring the resin temperature to 150°C.

Thereafter, a PLA biodegradable sheet mixed with ZnO (referred to as "nZnO") having a thickness of 300 μm was prepared by discharging in an extrusion direction from an annular die having cylindrical slits with a diameter of 110 mm and a slit interval of 0.5 mm.

Using the prepared PLA biodegradable sheet, an egg seat was manufactured by injection molding with a bottom plate in which three concave egg seat grooves are arranged to accommodate eggs and a detachable lid covering the entire egg seat groove of the bottom plate.

<실시예 2> <Example 2>

PLA mixed with ZnO/CuI was carried out in the same manner as in Example 1, except that 1 part by weight of ZnO nanoparticles and 1 part by weight of CuI were mixed with 100 parts by weight of PLA resin (Total Corbion's Lumini L175). An egg nest was prepared in the same manner as in Example 1, except that a biodegradable sheet (referred to as “CuZn”) was prepared and injection molded.

<실시예 3> <Example 3>

With respect to 100 parts by weight of PLA resin (Total Corbion's Lumini L175), 1 part by weight of silica particles (AgNP) in which silver ions and zinc ions are combined as silver ion-containing nanocomposites are mixed. Same as Example 1 above. An egg nest was prepared in the same manner as in Example 1, except that a PLA biodegradable sheet (referred to as "AgNP") in which the silver ion-containing nanoparticle-containing composite was incorporated was prepared and injection molded. .

<실시예 4> <Example 4>

With respect to 100 parts by weight of PLA resin (Total Corbion's Lumini L175), except that 1 part by weight of CuI was mixed, the same procedure as in Example 1 was carried out, CuI-incorporated PLA biodegradable sheet (referred to as "CuI") ) was prepared and an egg seat was prepared in the same manner as in Example 1, except that injection molding was performed.

<실시예 5> <Example 5>

Except for mixing 1 part by weight of ZnO nanoparticles, 1 part by weight of silver ion and zinc ion-bonded silica particles (AgNP) and 1 part by weight of CuI with respect to 100 parts by weight of PLA resin (Total Corbion's Lumini L175), Same as Example 1, except that a PLA biodegradable sheet (referred to as “nZnAgCu”) mixed with ZnO/silver ion-containing nanocomposite/CuI was prepared and injection molded. This was done to produce an egg ovary.

<실시예 6> <Example 6>

Based on 100 parts by weight of PLA resin (Hisun's Revode 190), 1.0 parts by weight of an epoxy-based chain extender as a chain extender, 1.8 parts by weight of talc having a size of 0.1 to 5 μm as a foaming nucleating agent, and 1.0 parts by weight of a plasticizer (Acetyl tributyl citrate) After mixing parts by weight and 1 part by weight of ZnO nanoparticles, mixing well using a general mixer such as a tumbling mixer, and then using a twin-screw extruder with an inner diameter of 65 mm to prepare pellets of a uniform composition, the pellets have an inner diameter of 90 mm An extruded foam sheet was prepared by introducing raw materials into the first extruder and using a tandem type extruder in which a first extruder having an inner diameter of 90 mm and a second extruder having an inner diameter of 120 mm were connected.

The polylactic acid resin particles were supplied to the first extruder, melted and kneaded by heating, and then 2.5 parts by weight of butane as a foaming agent was press-injected into the first extruder to maintain a residence time of 10 minutes. Thereafter, the PLA resin mixed with ZnO was extruded on one side of the foam sheet using a separate T-die extruder to form a lamination coating layer having a thickness of 300 μm.

The sheet was manufactured and injection molded to produce an egg seat composed of a bottom plate in which three concave egg seat grooves are arranged to accommodate eggs and an integral lid connected to the base plate and covering the entire egg seat groove of the bottom plate.

<실시예 7><Example 7>

In Example 4, instead of PLA, PLA/PBAT/CaCO ₃ (filler) was made of a raw material resin consisting of 25/55/20% by weight, except that a PLA-based non-foaming sheet was manufactured and injection molded. An egg nest was prepared in the same manner as in Example 6.

<실시예 8><Example 8>

In Example 4, instead of PLA, PBS / PBAT / TPS (modified starch), except that a PLA-based non-foaming sheet made of a raw material resin consisting of 15/55/30% by weight was manufactured and injection molded, An egg nest was prepared in the same manner as in Example 6.

<실시예 9> <Example 9>

With respect to 100 parts by weight of PLA resin (Total Corbion's Lumini L175), 1 part by weight of ZnO nanoparticles and 0.01 part by weight of ferrite nanoparticles were mixed to prepare a PLA biodegradable sheet (referred to as "ZnOFe") incorporating ZnO/ferrite. Egg nests were prepared in the same manner as in Example 1, except for one exception. In this case, alpha-ferrite (α-Fe ₂ O ₃ ), zinc ferrite (ZnFe ₂ O ₄ ), and manganese ferrite (MnFe ₂ O ₄ ) were mixed with the ferrite nanoparticles.

<비교예 1><Comparative Example 1>

It was carried out in the same manner as in Example 1, except that the inorganic antiviral agent was not mixed with the PLA resin (Total Corbion's Lumini L175) used in Example 1.

<실험예 1> 시트의 모폴러지(morphology) 평가<Experimental Example 1> Sheet morphology evaluation

For the PLA biodegradable sheet having a thickness of 300 μm containing the inorganic antiviral agent prepared in Examples 1 to 5, cross-sections of the sheet were photographed using an electron microscope (manufactured by Bruker).

5 to 9 show cross-sectional photographs of the PLA biodegradable sheets prepared in each example, and overall good dispersion of the inorganic antiviral agent and individual particles or two or more aggregated composite particles are dispersed in a size of 100 to 300 nm. result was confirmed.

In particular, in the PLA biodegradable sheet incorporating the silver ion-containing nanocomposite of Example 3, it was confirmed that 50% or more of individual particles or composite particles aggregated of two or more kinds were 150 to 200 nm.

<실험예 2> 항바이러스성능 평가<Experimental Example 2> Evaluation of antiviral performance

For the PLA biodegradable sheets containing the inorganic antiviral agent prepared in Examples 1 to 9, the antiviral performance was evaluated against influenza virus (FluA) or filine coronavirus (fCoV) [government contribution Researcher test evaluation].

Specifically, 5 μl of the corresponding virus solution was applied twice to the surface of the sheet (1 cm × 1 cm), 350 μl of MEM was added for virus recovery, the reaction time was set to 30 minutes, and room temperature (23 ° C.) was performed in

As for the evaluation criteria, virus reduction was observed 10 minutes and 2 hours after inoculation of the virus, and in Table 1 below, the virus reduction of the antiviral effect 2 hours after inoculation was expressed as log. At this time, the higher the number, the higher the removal rate.

From the results of Table 1, the inorganic antiviral agent contained in the biodegradable sheet of the present invention alone or two or more aggregated composite particles were dispersed in a particle size of 100 to 900 nm, and in Examples 1 to 9, silver In the case of a PLA biodegradable sheet containing an inorganic antiviral agent alone or in a mixture of two or more selected from the group consisting of ion-containing nanocomposites, copper monovalent compounds, zinc oxide nanoparticles and ferrite nanoparticles, influenza virus (FluA) or Fila It showed remarkable antiviral performance compared to Comparative Example 1 against human coronavirus (fCoV).

Therefore, egg yolks using a PLA biodegradable sheet are dispersed in a particle size of 100 to 900 nm in which inorganic antiviral agents alone or aggregated composite particles of two or more kinds are dispersed, and the particle size is sufficient to prevent skin penetration of inorganic antiviral agents. While meeting the above, excellent antiviral performance can be realized by inactivating the virus before entering the human body by contact with the external virus or inhibiting RNA replication even after being infected.

<실시예 10∼24> <Examples 10 to 24>

An inorganic antiviral active layer was formed by applying a coating composition having antiviral performance to one side of a biodegradable base sheet made of biodegradable raw material resin by Mayer bar coating or mist spraying method, and the sheet prepared according to Table 2 below was injection molded. Thus, an egg yolk was prepared.

<실험예 3> 항바이러스성능 평가<Experimental Example 3> Evaluation of antiviral performance

Antiviral biodegradable PLA prepared in Examples 10 to 24 above On the surface of the sheet cut into circles with a diameter of 1 cm, 5 μl of influenza A virus (FluA) and (Human, H3N2) solutions were repeatedly added, and a reaction time of 30 minutes at room temperature (23 ° C) was used for cell lines using MDCK cells. , virus titration was performed using the CPE/MTT assay method to evaluate antiviral performance.

In addition, 5 μl of fill-in coronavirus (fCoV) solution was repeatedly dropwise added to the surface of an antiviral biodegradable sheet (1 cm × 1 cm), and the cell line was prepared using a CRFK cell and at room temperature (23 ° C) for a reaction time of 30 minutes. , virus titration was performed using the CPE/MTT assay method to evaluate antiviral performance [Government-funded research institute test evaluation].

The results are shown in Table 3 .

From the results of Table 3, in the antiviral biodegradable sheet of the present invention, the inorganic antiviral agent alone or two or more aggregated composite particles were dispersed in a particle size of 100 to 900 nm, and influenza A virus (FluA) and filine corona For the virus (fCoV), it showed a virus reduction rate of up to 99.999% within 30 minutes of contact with the virus.

Although the present invention has been described in detail only with respect to the specific embodiments described above, it is obvious to those skilled in the art that various changes and modifications are possible within the scope of the technical idea of the present invention, and it is natural that such changes and modifications fall within the scope of the appended claims.

Claims

An egg seat composed of a bottom plate in which one or more concave egg seat grooves are arranged to accommodate eggs, a detachable lid covering the entire egg seat groove of the bottom plate, or an integral lid connected to the bottom plate and covering the entire egg seat groove of the bottom plate in

The base plate or the base plate and the lid

A biodegradable polymer resin made of a polylactic acid-based polymer; or a composite degradable polymer resin composed of a biodegradable resin and a petrochemical resin; composed of a biodegradable sheet prepared by dispersing an inorganic antiviral agent alone or a composite particle in which two or more aggregated composite particles are dispersed to a particle size of 100 to 900 nm in a raw material resin selected from A biodegradable egg ovary with antiviral properties.
The method of claim 1, wherein the inorganic antiviral agent is selected from the group consisting of silver nanoparticle complexes, silver ion-containing nanocomposites, copper monovalent compounds, zinc oxide nanoparticles and ferrite nanoparticles. A biodegradable egg ovary with antiviral properties.
The method of claim 2, wherein the silver nanoparticle composite or silver ion-containing nanocomposite is made of minerals including silica (SiO 2 ), alumina, zeolite, sericite, mordenite, cristobalite, and bentonite, talc, cellulose derivatives, paraffin, and wax. A biodegradable egg egg seat having antiviral performance, characterized in that silver nanoparticles or silver ion-containing nanoparticles are adsorbed or bound to any one selected from the group consisting of.
The method of claim 2, wherein the ferrite nanoparticles are alpha-ferrite (α-Fe 2 O 3 ), zinc ferrite (ZnFe 2 O 4 ), manganese ferrite (MnFe 2 O 4 ), nickel ferrite (NiFe 2 O 4 ), and A biodegradable sheet having antiviral properties, characterized in that at least one selected from the group consisting of iron hydroxide (α-FeOOH) is blended.
The biodegradable egg yolk seat having antiviral properties according to claim 1, wherein 0.1 to 60 parts by weight of an inorganic antiviral agent is included with respect to 100 parts by weight of the biodegradable polymer resin or composite degradable polymer resin.
The method of claim 1, wherein the biodegradable resin is polylactic acid (PLA), polyhydroxyalkanoates (PHA), polybutylene adipate-co-terephthalate (PBAT), polybutylene succinate-co-adipate (PBSA), polybutylene succinate adipate-co-terephthalate (PBSAT), polybutylene succinate , PBS), polyvinyl alcohol (PVA), poly glycolic acid (PGA), poly lactic-co-glycolic acid (PLGA) and polycaprolactone , PCL), modified starch resin, and thermoplastic starch (thermoplastic starch, TPS).
The method of claim 1, wherein the base plate or the base plate and the lid

transparent polylactic acid (PLA) non-foaming sheet;

Opaque PLA non-foaming sheet;

An extruded foam sheet made of a PLA-based polymer; and

It is made of any one material selected from the group consisting of a multilayer sheet in which a non-foaming sheet made of a biodegradable polymer resin or a petrochemical resin is laminated on at least one surface of the extruded foam sheet, and the bottom plate And a biodegradable egg yolk seat having antiviral performance, characterized in that the lid is combined with the same sheet material or another sheet material.
[Claim 8] The biodegradable egg nest having antiviral properties according to claim 7, wherein a non-foaming sheet is laminated on the inner surface of the base plate made of extruded foam sheet or the outer surface of the base plate in the multi-layer sheet.
The biodegradable egg seat having antiviral properties according to claim 7, wherein the non-foaming sheet contains 0.1 to 60 parts by weight of an inorganic antiviral agent based on 100 parts by weight of the biodegradable polymer resin or petrochemical resin.
The biodegradable egg nest having antiviral properties according to claim 7, wherein the non-foaming sheet has a thickness of 50 to 500 μm.
The method of claim 7, wherein the transparent polylactic acid (Polylactic acid, PLA) non-foaming sheet;

Opaque PLA non-foaming sheet;

An extruded foam sheet made of a PLA-based polymer; and

On at least one side of the multi-layer sheet in which a non-foaming sheet made of a biodegradable polymer resin or a petrochemical resin made of a polylactic acid-based polymer is laminated on at least one side of the extruded foam sheet,

A biodegradable egg yolk seat having antiviral performance, characterized in that an inorganic antiviral active layer is formed by applying an active layer solution including a single or mixed form selected from inorganic antiviral agents and dispersants.
The method of claim 11, wherein the inorganic antiviral active layer is formed by a coating method or a spray method using a mist nozzle,

Biodegradable egg yolk with antiviral performance, characterized in that the inorganic antiviral agent is dispersed at 0.01 to 5 g / m 2.
The method according to any one of claims 1 to 12, wherein the antiviral performance is any one selected from the group consisting of filine coronavirus (fCoV), influenza A virus (FluA), avian influenza (AI) virus, and swine virus. A biodegradable egg locus with antiviral properties implemented in one or more.
With respect to 100 parts by weight of organic solvent,

0.1 to 20 parts by weight of an inorganic antiviral agent and

A coating composition having antiviral performance containing 0.1 to 20 parts by weight of a dispersing agent selected from the group consisting of polyethylene glycol (PEG), citric acid, lactic acid and polylactic acid (PLA).
The method of claim 14, wherein the inorganic antiviral agent is selected from the group consisting of silver nanoparticle complexes, silver ion-containing nanocomposites, copper monovalent compounds, zinc oxide nanoparticles and ferrite nanoparticles. A coating composition having antiviral properties.
The method of claim 15, wherein the silver nanoparticle composite or silver ion-containing nanocomposite is a mineral including silica (SiO 2 ), alumina, zeolite, sericite, mordenite, cristobalite, and/or bentonite, talc, cellulose derivative, paraffin, and wax A coating composition having antiviral performance, characterized in that silver nanoparticles or silver ion-containing nanoparticles are adsorbed or bound to any one selected from the group consisting of.
The method of claim 15, wherein the ferrite nanoparticles are alpha-ferrite (α-Fe 2 O 3 ), zinc ferrite (ZnFe 2 O 4 ), manganese ferrite (MnFe 2 O 4 ), nickel ferrite (NiFe 2 O 4 ) and A method for producing a biodegradable sheet having antiviral properties, characterized in that at least one selected from the group consisting of iron hydroxide (α-FeOOH) is blended.
15. The method of claim 14, wherein the organic solvent is tetrahydrofuran (THF), chlorinated organic solvents including chloroform, acetonitrile, dioxane and dimethylformamide (DMF), dimethylacetamide (DMAc), ethanol, methanol, normal- alcohols selected from propyl alcohol or iso-propyl alcohol; A coating composition having antiviral performance, characterized in that it is at least one from the group consisting of chlorinated organic solvents including chloroform, benzene, toluene, acetonitrile and dioxane.