WO2022247610A1 - 一种实验动物用颗粒物环境模拟发生装置 - Google Patents

一种实验动物用颗粒物环境模拟发生装置 Download PDF

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Publication number
WO2022247610A1
WO2022247610A1 PCT/CN2022/091390 CN2022091390W WO2022247610A1 WO 2022247610 A1 WO2022247610 A1 WO 2022247610A1 CN 2022091390 W CN2022091390 W CN 2022091390W WO 2022247610 A1 WO2022247610 A1 WO 2022247610A1
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Prior art keywords
experimental
chamber
cavity
experimental animal
air
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PCT/CN2022/091390
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English (en)
French (fr)
Inventor
倪广健
陈力群
高鑫禹
陈岳
郭晓宇
Original Assignee
天津大学合肥创新发展研究院
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Priority to US17/994,413 priority Critical patent/US20230097259A1/en
Publication of WO2022247610A1 publication Critical patent/WO2022247610A1/zh

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K1/00—Housing animals; Equipment therefor
    • A01K1/0047—Air-conditioning, e.g. ventilation, of animal housings
    • A01K1/0064—Construction of air inlets or outlets in walls
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K1/00—Housing animals; Equipment therefor
    • A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
    • A01K1/03—Housing for domestic or laboratory animals
    • A01K1/031—Cages for laboratory animals; Cages for measuring metabolism of animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K1/00—Housing animals; Equipment therefor
    • A01K1/0047—Air-conditioning, e.g. ventilation, of animal housings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K1/00—Housing animals; Equipment therefor
    • A01K1/01—Removal of dung or urine, e.g. from stables
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K1/00—Housing animals; Equipment therefor
    • A01K1/01—Removal of dung or urine, e.g. from stables
    • A01K1/0107—Cat trays; Dog urinals; Toilets for pets
    • A01K1/011—Cat trays; Dog urinals; Toilets for pets with means for removing excrement
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K1/00—Housing animals; Equipment therefor
    • A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
    • A01K1/035—Devices for use in keeping domestic animals, e.g. fittings in housings or dog beds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K1/00—Housing animals; Equipment therefor
    • A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
    • A01K1/035—Devices for use in keeping domestic animals, e.g. fittings in housings or dog beds
    • A01K1/0356—Feeding or drinking devices associated with cages
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K29/00—Other apparatus for animal husbandry
    • A01K29/005—Monitoring or measuring activity, e.g. detecting heat or mating
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/02—Breeding vertebrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
    • B01D46/30—Particle separators, e.g. dust precipitators, using loose filtering material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B01J19/10—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing sonic or ultrasonic vibrations

Definitions

  • the invention relates to the field of animal environment simulation devices, in particular to a particulate matter environment simulation generation device for experimental animals.
  • the more common research methods are to study the biological effects of particulate matter on animals by intravenous injection and nasal drip, or by placing animals in prepared experimental boxes to study and evaluate changes in their physical and cognitive levels.
  • the environment in the box cannot be the same as the environment simulated in the animal body, which leads to deviations in the experimental data and affects the accuracy of the overall experimental data.
  • the current particle experiment box has a single simulation environment, and its main function is to simulate PM particles. It is impossible to centrally realize the environmental simulation of various particle environments such as nanoparticles, virus particles in the air, dust and PM particles.
  • the purpose of the present invention is to provide a particle environment simulation generating device for experimental animals, so as to solve the problem of inability to centrally simulate various particle environments in animal experiments in the prior art.
  • a particle environment simulation generating device for experimental animals comprising a closed experimental box 1, the interior of the experimental box 1 is divided into upper, middle and lower three-layer spaces by partitions, wherein the uppermost space is the experimental animal placement chamber 13, and the lowermost The space is the air supply chamber 11 at the bottom, and the space in the middle layer is the drawing chamber 12, where:
  • experimental case 1 case wall or case top is provided with put into mouth 23 corresponding to experimental animal placement cavity 13 positions, put into port 23 and be equipped with the sealing plate 21 that can open or close;
  • Experimental case 1 case wall is corresponding to experimental animal place
  • the cavity 13 is also provided with a ventilation tube 14, which is used for air intake and deflation into the cavity 13 where the experimental animal is placed, and the ventilation tube 14 is communicated with a particle filter device 8;
  • the interlayer between the experimental animal placement chamber 13 and the drawing chamber 12 is provided with a plurality of first drop holes that pass through the interlayer up and down, and each first drop hole communicates with the experimental animal when there is no shelter.
  • the wall of the experiment box 1 is provided with a drawing port 122 corresponding to the position on one side of the drawing chamber 12, and the drawing chamber 12 is equipped with a drawer that is adapted to the drawing port 122 and can be drawn out from the drawing port 122.
  • the excrement storage device 3 is composed of the excrement storage device 3 and the drawer chamber 12 to form a drawer structure; the excrement storage device 3 has a storage chamber 32 inside, and the top of the excrement storage device 3 is open, and the excrement storage device 3 is open.
  • the holding device 3 is under the interlayer between the experimental animal placement chamber 13 and the drawing chamber 12 through its holding chamber 32;
  • the top surface of the sealing plate 61 is closely attached to the bottom surface of the interlayer between the experimental animal placement cavity 13 and the drawing cavity 12, and the wall of the experimental box 1 is provided with a sealing plate 61 on the side corresponding to the sealing plate 61.
  • the upper bayonet 121 that is pushed in and drawn out, the side of the sealing plate 61 corresponding to the upper bayonet 121 extends to be inserted into the upper bayonet 121; the sealing plate 61 is provided with a plurality of vertically penetrating sealing plates
  • the second drop hole 62 of 61, the second drop hole 62 in the sealing plate 61 is communicated with the first drop hole of the interlayer between the experimental animal placement chamber 13 and the drawing chamber 12 one by one, and the sealing plate
  • the inner diameter of each second drop hole 62 in 61 is less than or equal to the first drop hole corresponding to the second drop hole 62, and the corresponding first drop hole is adjacent to the first drop hole in the pulling direction of the sealing plate 61.
  • the inside of the bottom air supply chamber 11 is provided with an ultrasonic atomization device 4 and a guide device 5.
  • the guide device 5 includes an air sealing cover 51. There is a cavity in the air sealing cover 51, and a fan is installed in the cavity of the air sealing cover 51. , the outlet end of the ultrasonic atomization device 4 communicates with the cavity in the air sealing cover 51, and the particles generated by the ultrasonic atomizing device 4 and passed into the air sealing cover 51 move through the fan; the air sealing cover 51 also At least one air guide tube 52 is configured, the air intake end of the air guide tube 52 communicates with the cavity in the air sealing cover 51, and the outlet end of the air guide tube 52 passes through the bottom air delivery chamber 11 and then penetrates into the experimental animal placement chamber 13 .
  • the top of the experimental box 1 is opened to expose the experimental animal placement chamber 13, and the top cover of the experimental box 1 is equipped with an upper end cover 22, and the upper end cover 22 makes the experimental box 1 closed.
  • the mouth 23 is arranged on the cover body of the upper end cover 22; the bottom side wall of the upper end cover 22 is fixed with a ring of connecting clips 24, and the outer side wall of the sealed box 1 is located at the position below the connecting clip 24 and is fixed with a ring of receiving bars 18, so
  • the connecting clip 24 is attached to the connecting clip 24 and connected with the connecting clip 24 by screws.
  • At least one of the germicidal lamp and the lighting lamp is fixed on the side of the upper end cover 22 facing the chamber 13 for placing the experimental animal.
  • At least one of the TSI detector 7 , a thermometer and a hygrometer is installed inside the chamber 13 where the experimental animal is placed.
  • TSI detector 7 is installed in the installation port 15 that test case 1 case wall offers, and thermometer, hygrometer are installed in the measuring device fixing frame 16 that is fixed on test case 1 case inner wall.
  • the wall of the experimental box 1 is also provided with a plurality of food openings 171 corresponding to the position of the experimental animal placement chamber 13, and the two symmetrical sides of each food opening 171 are fixedly connected with a diet fixing plate 17 respectively, and the two symmetrical sides of each food opening 171 are fixedly connected with a diet fixing plate 17 for placing
  • the sealing baffle plate of soft rubber material is installed in the inside of food mouth 171, and the food bucket 9 that is used to hold animal food and drinking water is slidably connected between the two diet fixing plates 17 corresponding to each food mouth 171.
  • the air pipe 14 is communicated with the installed particle filter device 8 and includes a connecting pipe 81 and a filter plug 82.
  • the connecting pipe 81 is threadedly connected to the air pipe 14.
  • the filter plug 82 is provided with filter cotton for filtering particulate matter.
  • the main body of the excrement storage device 3 is a storage cabinet 31 adapted to the drawer opening 122.
  • the top of the storage cabinet 31 is open and the interior is a storage cavity 32.
  • the storage cabinet 31 is far away from the
  • the top of one side of the upper bayonet 121 is provided with a stepped portion for supporting the corresponding side of the sealing plate 61 , and the stepped portion of the storage cabinet 31 cooperates with the upper bayonet to jointly support the sealing plate 61 .
  • the side end surface of the blocking plate 61 supported on the step part of the storage cabinet 31 is provided with a side card slot 63, and the position of the step part of the storage cabinet 31 corresponding to the side card slot 63 is fixed with a card position. strips, and the clamping strips are inserted into the side clamping slots 63 at the corresponding positions.
  • At least one limit groove is provided at the bottom of the storage cabinet 31, and the limit groove extends along the drawing direction of the storage cabinet 31, and the compartment at the bottom of the drawer chamber 12 corresponds to the limit groove
  • the position is fixed with a pull-out limit bar 123 , and the pull-out limit bar 123 is plugged into a limit slot at the bottom of the storage cabinet 31 .
  • the multiple air guide tubes 52 are paired into multiple pairs, and the gas outlet ends of the two air guide tubes in each pair are respectively connected to the experimental chamber.
  • the animal is placed in the chamber 13, and there are pipelines connected between the air outlet ends of the two air guide tubes in each pair, and the extension tubes 53 are bypassed in the middle of each pipeline, and the ends of the extension tubes 53 are respectively connected and fixed with loose balloons.
  • the tube wall of the pipeline and the side wall of the diffuser ball 54 are respectively provided with a plurality of diffuser holes 55 for ventilation.
  • the atomized particles generated by the ultrasonic atomization device are conducted to the interior of the experimental animal placement chamber through the set guide device, so that the interior of the experimental animal placement chamber is filled with simulated particles, Make the animals placed in the experimental animal chamber absorb the atomized particles, ensure that the animals will not be disturbed in the simulated environment, ensure the stability of the experimental environment, and improve the accuracy of experimental data detection.
  • the excrement holding device is set to collect the excrement of animals, and at the same time, the blocking seal that blocks the bottom of the experimental animal placement cavity is set on the excrement holding device device, when the excrement holding device needs to dump animal excrement, by adjusting the position of the blocking device, the bottom of the experimental animal placement chamber is blocked and sealed, so that the excrement holding device can be taken out from the drawing chamber, reducing the risk of Damage to the internal airtightness of the device as a result of pulling on the waste containment device.
  • the tube filter device arranged on the ventilation tube filters the gas entering and exiting the chamber where the experimental animals are placed, so as to prevent the outside gas from entering the chamber where the experimental animals are placed through the ventilation tube. Influence the environment inside the cavity where the experimental animals are placed, thereby ensuring the accuracy of the data detected by the experiment.
  • the ultrasonic atomization device can meet the simulation requirements of various particulate matter environments other than PM particulate matter environment simulation, and realize the collection of nanoparticles, virus particles in the air, dust and PM
  • the multi-environment simulation that integrates particulate matter and other environments enriches the types of environmental simulation.
  • Fig. 1 is the overall structure schematic diagram of the embodiment of the present invention.
  • Fig. 2 is the overall sectional structure schematic diagram of the embodiment of the present invention.
  • FIG. 3 is a schematic cross-sectional structure diagram of an overall part of an embodiment of the present invention.
  • Fig. 4 is a schematic diagram of the exploded structure of the whole part of the embodiment of the present invention.
  • Fig. 5 is the schematic diagram of the sectional structure of the experimental box of the embodiment of the present invention.
  • Fig. 6 is a schematic cross-sectional structure diagram of an upper sealing device according to an embodiment of the present invention.
  • Fig. 7 is a schematic cross-sectional structure diagram of an excrement holding device according to an embodiment of the present invention.
  • Fig. 8 is a schematic structural diagram of a guiding device according to an embodiment of the present invention.
  • Fig. 9 is a schematic cross-sectional structure diagram of a sealing device according to an embodiment of the present invention.
  • Fig. 10 is a schematic diagram of an exploded structure of a tube filter device according to an embodiment of the present invention.
  • Blocking device 61. Blocking plate; 62. Drop hole; 63. Side card slot;
  • first and second are used for descriptive purposes only, and cannot be interpreted as indicating or implying relative importance or implicitly specifying the quantity of indicated technical features. Thus, a feature defined as “first” and “second” may explicitly or implicitly include one or more of these features.
  • “plurality” means two or more, unless otherwise specifically defined.
  • the present invention provides a kind of particulate matter environment simulation generation device for experimental animals, a kind of particulate matter environment simulation generation device for experimental animals, comprising an experimental box 1, the inside of the experimental box 1 is separated by a partition It is the upper, middle and lower three-layer space, wherein the uppermost space is the experimental animal placement chamber 13, the lowermost space is the bottom air supply chamber 11, and the middle layer space is the drawing chamber 12.
  • the top of the experimental box 1 is opened to expose the experimental animal placement cavity 13, and an upper end cover 22 is installed on the top cover of the experimental box 1, and the experimental box 1 is closed by the upper end cover 22.
  • the cover body of the upper end cover 22 is provided with an inlet 23. Put the experimental animal into the experimental animal placement chamber 13, the opening 23 is hinged with a sealing plate 21, the sealing plate 21 can completely close and seal the opening 23 and turn to open from the opening 23, from the upper end
  • the cover 22 and the sealing plate 21 seal the experimental box 1 .
  • the bottom side wall of the upper end cover 22 is fixed with a ring of connecting clips 24, and the outer wall of the sealed box 1 is located below the connecting clip 24 and is fixed with a ring of connecting clips 18.
  • the connecting clips 24 are closely attached to the connecting clips 24 and connected with the connecting clips.
  • the strips 24 are connected by screws.
  • the upper sealing device 2 is composed of a sealing plate 21 , an upper end cover 22 , an insertion opening 23 , and a connecting clip 24 .
  • the germicidal lamp is an ultraviolet lamp, which is used to sterilize the chamber 13 where the experimental animals are placed, and the lighting lamp is used to illuminate the chamber 13 where the experimental animals are placed.
  • TSI detector 7, thermometer and hygrometer are installed inside the experimental animal placement chamber 13, wherein TSI detector 7 is installed in the installation port 15 corresponding to the rear side wall of the experimental animal placement chamber 13 in the experimental box 1, and the thermometer, humidity After the meter is integrated, it is jointly fixed to the measuring device fixing frame 16 on the inner wall of the chamber 13 where the experimental animal is placed.
  • Experiment box 1 is also provided with a plurality of feeding openings 171 corresponding to the rear side wall of experimental animal placement chamber 13, and each feeding opening 171 two symmetrical sides are fixedly connected with diet fixing plate 17 respectively, and the inside of feeding opening 171 is installed with
  • the sealing baffle plate of soft rubber material is slidably connected with the food bucket 9 for holding animal food and drinking water between the two diet fixing plates 17 corresponding to each food opening 171 .
  • the left and right sides of the experimental box 1 are also provided with ventilation pipes 14 corresponding to the positions of the experimental animal placement chamber 13, wherein one ventilation pipe is used for air intake, and the other ventilation pipe is used for air outlet, and each ventilation pipe 14 is respectively connected and installed.
  • the particle filtering device 8 includes a connecting pipe 81 and a filter plug 82, wherein the connecting pipe 81 is coaxially threaded to the pipe end of the corresponding vent pipe 14, the filter plug 82 is arranged inside the connecting pipe 81 and inserted into the vent pipe 14, and the filter plug 82 are provided with filter cotton for filtering particulate matter inside.
  • the interlayer between the experimental animal placement chamber 13 and the drawing chamber 12 is provided with a plurality of first drop holes that pass through the interlayer up and down. Arranged in rows and columns at equal intervals, each first drop hole communicates with the experimental animal placement chamber 13 and the drawing chamber 12 when there is no shelter.
  • the left side wall of the experimental box 1 is provided with a drawing port 122 corresponding to the position of the drawing chamber 12, and the drawing chamber 12 is equipped with an excrement holding device 3 that can be drawn out from the drawing port 122, and is held by the excrement.
  • the device 3 and the drawer chamber 12 form a drawer structure.
  • the main body of the excrement storage device 3 is a storage cabinet 31 adapted to the drawer opening 122.
  • the top of the storage cabinet 31 is open and the interior is a storage cavity 32. It is placed under the interlayer between the experimental animal placement chamber 13 and the drawing chamber 12 .
  • the top opening of the holding cabinet 31 is covered with a sealing plate 61, and the top surface of the sealing plate 61 is closely attached to the bottom surface of the interlayer between the experimental animal placement cavity 13 and the drawing cavity 12, and the right side wall of the experimental box 1 corresponds to
  • On the right side of the blocking plate 61 there is an upper bayonet 121 for pushing in and out the blocking plate 61.
  • the right side of the blocking plate 61 extends to be inserted into the upper bayonet 121.
  • the top left side of the storage cabinet 31 is set as The step portion is used to support the left side of the sealing plate 61 , and the sealing plate 61 is jointly supported by the step portion of the storage cabinet 31 and the upper bayonet.
  • the sealing plate 61 , the upper bayonet 121 , and the top of the storage cabinet 31 also form a drawer structure, so that the sealing plate 61 can be pulled out from the upper bayonet 121 to the right.
  • the sealing plate 61 is provided with a plurality of second drop holes 62 that pass through the sealing plate 61 up and down, and the plurality of second falling holes 62 are distributed in an array of equal intervals, and the second falling holes 62 in the sealing plate 61 It communicates with the first drop hole of the compartment between the experimental animal placement cavity 13 and the drawing cavity 12 one by one, and the inner diameter of each second drop hole 62 in the blocking plate 61 is less than or equal to the adjacent first drop hole. spacing between holes.
  • the sealing plate 61 when the sealing plate 61 is pulled, it can move until the second drop hole 62 and the first drop hole are staggered in a one-to-one correspondence, so that the blocking plate 61 can move to completely block the experimental animal when it is pulled.
  • the row and column array of the first drop holes in the interlayer between the placement chamber 13 and the drawing chamber 12 are provided with a plurality of second drop holes 62 that pass through the sealing plate 61 up and down, and the plurality of second falling holes 62 are distributed in an array
  • the inner diameter of the first drop hole can be the same as the inner diameter of the second drop hole 62, or it can be different, but as long as it meets the inner diameter of each second drop hole 62, it is less than or equal to the second drop hole 62 corresponding to the first drop hole, and the distance between the corresponding first drop hole in the pulling direction of the sealing plate 61 (the left and right direction in this embodiment) adjacent to the first drop hole, can meet the requirements of the blocking When the sealing plate 61 is twitched, it can completely block the arrays of the first drop holes.
  • the baffle plate 61 is supported on the left end face of the step portion of the storage cabinet 31 to be provided with a side card slot 63, and the step portion on the left side of the storage cabinet 31 is fixed with a card position bar corresponding to the position of the side card slot 63, and the card position bar is inserted into the In the corresponding side slot 63.
  • the bottom of the storage cabinet 31 is provided with at least one limiting groove extending along the drawing direction of the storage cabinet 31 (the left and right directions in this embodiment), and the compartment at the bottom of the drawing chamber 12 is fixed with a drawing limiter corresponding to the position of the limiting groove.
  • the bar 123 is inserted into the limiting groove at the bottom of the storage cabinet 31 by pulling the limiting bar 123 .
  • the bottom air supply chamber 11 is provided with an ultrasonic atomization device 4 and a guiding device 5.
  • the guiding device 5 includes an air sealing cover 51. There is a cavity in the air sealing cover 51. A fan is installed in the cavity of the air sealing cover 51, and the ultrasonic mist The atomization device 4 is integrated with the gas sealing cap 51 and then installed in the opening at the bottom of the bottom air supply chamber 11 , the outlet end of the ultrasonic atomization device 4 communicates with the cavity in the gas sealing cap 51 .
  • the gas sealing cover 51 is also equipped with at least one air guide tube 52, the air intake end of the air guide tube 52 communicates with the cavity in the air sealing cover 51, and the outlet end of the air guide tube 52 passes through two layers of interlayers, and then penetrates into the experimental animal for placement.
  • the gas sealing cover 51 When the gas sealing cover 51 is equipped with a plurality of air guide tubes 52, the plurality of air guide tubes 52 are paired into multiple pairs, and the gas outlet ends of the two air guide tubes in each pair are respectively connected to the experimental animal placement cavity 13, and each pair There are pipelines connected between the gas outlet ends of the two air guide tubes, and the middle of each pipeline is connected with an extension tube 53 by bypass respectively.
  • the side walls of the diffuser balloons 54 are respectively provided with a plurality of diffuser holes 55 for ventilation.
  • the sealing plate 21 is opened from the insertion port 23 by turning over the sealing plate 21, and the experimental animals are passed through the insertion port. 23 is put into the interior of the experimental animal placement cavity 13, so that the experimental animals can survive in the designated simulation space. After the experimental animals are placed, the sealing plate 21 is covered on the insertion port 23, so that the upper sealing device 2 and the experimental box 1 is sealed to ensure that the experimental environment of the experimental animal is separated from the external environment, and the accuracy of the experimental detection data is improved. After the experimental animal excretes, the excrement of the animal falls into the excrement holding device 3, and the excrement is contained.
  • the excrement storage device 3 is used to collect the excrement, so that when there is too much animal excrement, the excrement can be dumped out by moving the excrement holding device 3, so as to ensure the normal progress of the simulated particulate matter environment experiment.
  • the ultrasonic atomization device 4 When the guide device 5 in this embodiment is in use, the ultrasonic atomization device 4 is turned on, and the cavitation effect produced by the ultrasonic waves in the ultrasonic atomization device 4 in the liquid medium causes the generation of micro-shock waves, which will be placed in the ultrasonic atomization device
  • the solution particles used in the experiment in 4 are atomized, and the atomized solution particles are driven into the air duct 52 by the micro fan in the air sealing cover 51, and follow the duct of the air duct 52 to flow into the experimental animal placement chamber 13,
  • the environment in the experimental animal placement chamber 13 is changed to change the particle content inside the experimental animal placement chamber 13.
  • the experimental animal When the experimental animal moves in the experimental animal placement chamber 13, it absorbs the particle gas in the experimental animal placement chamber 13, eliminating the need for The trouble of intravenous injection and nasal drip effectively reduces the influence of the experiment due to environmental differences, enhances the accuracy of the data on the body changes of experimental animals in the simulated environment, and makes experimental animals more research meaningful and valuable.
  • the excrement holding device 3 when the excrement holding device 3 needs to take out the animal's excrement, by pulling the blocking plate 61, the blocking plate 61 and the first drop hole 62 at the bottom of the experimental animal placement cavity 13 are staggered,
  • the baffle plate 61 seals the bottom of the experimental animal placement chamber 13, preventing the gas in the experimental animal placement chamber 13 from entering the drawing chamber 12 through the drop hole 62, and also preventing the outside air from entering the drawing chamber 12 through the drawing port 122.
  • the experimental animals are placed in the chamber 13, reducing damage to the airtightness inside the device.
  • the food bucket 9 provided in the experimental animal placement cavity 13 is used for the diet of the experimental animals to ensure the normal survival of the experimental animals, and a sealing rubber plate is set on the feeding port 171 to hold food.
  • a sealing rubber plate is set on the feeding port 171 to hold food.
  • the inside of the upper end cover 22 is equipped with an ultraviolet lamp for sterilization and an illumination lamp tube for lighting, and an ultraviolet lamp is arranged in the upper end cover 22 for sterilization before and after the experiment, and the illumination lamp tube is installed.
  • Dark sky can also simulate the effect of different light on organisms.
  • the particle filter device 8 filters the gas passing through the ventilation pipe 14 to ensure the purity of the air entering and exiting the chamber 13 where the experimental animal is placed, and to ensure the accuracy of the experimental detection data.

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  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Biophysics (AREA)
  • Birds (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Organic Chemistry (AREA)
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Abstract

一种实验动物用颗粒物环境模拟发生装置，包括实验箱(1)，实验箱(1)的上侧设置有上密封装置(2)，实验箱(1)的内部靠近中部的位置设置有用于盛放动物排泄物的排泄物盛放装置(3)，实验箱(1)的底部靠近中心的位置安装有超声雾化装置(4)，超声雾化装置(4)的上侧连接有用于引导颗粒的引导装置(5)；引导装置(5)包括封气盖(51)，封气盖(51)的内部安装有用于带动超声雾化装置(4)中产生的颗粒移动的微型风机，封气盖(51)的侧壁上左右对称固定连接有导气管(52)。实验动物用颗粒物环境模拟发生装置主要解决目前通过对动物进行腹腔注射、尾静脉注射、鼻腔滴注等方式无法准确有效模拟颗粒物在动物体内的生物效应的问题，保证整体实验数据的准确性。

Description

一种实验动物用颗粒物环境模拟发生装置 技术领域
本发明涉及动物环境模拟装置领域，具体是一种实验动物用颗粒物环境模拟发生装置。
背景技术
在研究动物在不同的环境中的身体的变化时，通常是通过对实验动物进行静脉注射、鼻腔滴注的方式，来模拟颗粒物对实验动物的组织器官产生的影响，以研究暴露于不同模拟环境下机体所产生的生物效应。
目前较为普遍的研究方法是对动物静脉注射、鼻腔滴注研究颗粒物的生物效应或将动物放置在准备好的实验箱中，研究并评价其身体及认知水平等方面的变化，但目前的实验箱中的环境无法和动物体内模拟出的环境相同，导致实验数据存在偏差，影响整体实验数据的准确性。此外目前颗粒物实验箱模拟环境单一，主要功能以模拟PM颗粒物为主，无法集中实现多种颗粒物环境如纳米颗粒物、空气中携带病毒颗粒物、粉尘及PM颗粒物的环境模拟。
发明内容
本发明的目的是提供一种实验动物用颗粒物环境模拟发生装置，以解决现有技术动物实验时存在的无法集中模拟多种颗粒物环境的问题。
为了达到上述目的，本发明所采用的技术方案为：
一种实验动物用颗粒物环境模拟发生装置，包括封闭的实验箱1，实验箱1内部被隔层隔分为上、中、下三层空间，其中最上层空间为实验动物放置腔13，最下层空间为底部送气腔11，中间层空间为抽拉腔12，其中：
所述实验箱1箱壁或箱顶对应于实验动物放置腔13位置设有放入口23，放入口23安装有可打开或闭合的密封板21；实验箱1箱壁对应于实验动物放置腔13位置还设有通气管14，所述通气管14用于向实验动物放置腔13内进气和放气，通气管14连通安装有颗粒物过滤装置8；
所述实验动物放置腔13和抽拉腔12之间的隔层中设有多个上下贯通所述隔层的第一落物洞，每个第一落物洞在无遮挡时连通所述实验动物放置腔13和抽 拉腔12；
所述实验箱1箱壁对应于所述抽拉腔12一侧位置设有抽拉口122，所述抽拉腔12内安装有与抽拉口122适配并可从抽拉口122抽出的排泄物盛放装置3，由排泄物盛放装置3和抽拉腔12构成抽屉结构；所述排泄物盛放装置3内部有盛放腔32，排泄物盛放装置3顶部敞口，排泄物盛放装置3通过其盛放腔32承接于实验动物放置腔13、抽拉腔12之间的隔层下方；所述排泄物盛放装置3顶部敞口处盖装有挡封板61，所述挡封板61顶面紧贴于实验动物放置腔13、抽拉腔12之间的隔层底面，所述实验箱1箱壁对应于挡封板61一侧位置设有用于挡封板61推入和抽出的上卡口121，所述挡封板61对应于上卡口121的一侧延伸至插入上卡口121内；所述挡封板61中设有多个上下贯通挡封板61的第二落物洞62，挡封板61中的第二落物洞62与实验动物放置腔13、抽拉腔12之间隔层的第一落物洞一一对应连通，且挡封板61中每个第二落物洞62的内径，小于或等于第二落物洞62对应的第一落物洞、对应的第一落物洞在挡封板61抽拉方向上的相邻第一落物洞之间间距；
所述底部送气腔11内部设置有超声雾化装置4、引导装置5，所述引导装置5包括封气盖51，封气盖51内有空腔，封气盖51的空腔内安装有风机，所述超声雾化装置4的出口端与封气盖51内的空腔连通，并通过风机使超声雾化装置4产生并通入至封气盖51内部的颗粒物移动；封气盖51还配置有至少一个导气管52，导气管52进气端与封气盖51内的空腔连通，导气管52出气端穿出所述底部送气腔11后再穿入至所述实验动物放置腔13。
作为本技术方案的进一步改进，实验箱1顶部敞开使实验动物放置腔13露出，且实验箱1顶部套盖安装有上端盖22，由上端盖22使所述实验箱1封闭，所述放入口23设置于上端盖22的盖体；所述上端盖22的底部侧壁固定有一圈连接卡条24，所述密封箱1外侧壁位于连接卡条24下方位置固定有一圈承接条18，所述连接卡条24贴合于连接卡条24并与连接卡条24通过螺钉连接。
作为本技术方案的进一步改进，上端盖22朝向实验动物放置腔13的一面固定有杀菌灯、照明灯两者中的至少一者。
作为本技术方案的进一步改进，实验动物放置腔13内部安装有TSI检测仪7、温度计、湿度计三者中的至少一者。其中TSI检测仪7安装于实验箱1箱壁 开设的安装口15中，温度计、湿度计安装于固定于实验箱1箱内壁的测量装置固定架16。
作为本技术方案的进一步改进，实验箱1箱壁对应于实验动物放置腔13位置还设有多个放食口171，每个放食口171两对称侧分别固定连接有饮食固定板17，放食口171的内部安装有软橡胶材质的密封挡板，每个放食口171对应的两个饮食固定板17之间滑动连接有用于盛放动物食物和饮水的盛食桶9。
作为本技术方案的进一步改进，通气管14连通安装的颗粒物过滤装置8包括连接管81、过滤塞82，所述连接管81螺纹连接通气管14，所述过滤塞82设于连接管81内部并插接于通气管14内，过滤塞82内部设置用于过滤颗粒物的过滤棉花。
作为本技术方案的进一步改进，排泄物盛放装置3的主体为与抽拉口122适配的盛放柜31，盛放柜31顶部敞口并且内部为盛放腔32，盛放柜31远离所述上卡口121的一侧顶部设为台阶部用于支撑所述挡封板61对应侧，由盛放柜31的台阶部配合上卡口共同支撑所述挡封板61。
作为本技术方案的进一步改进，挡封板61支撑于盛放柜31台阶部的一侧端面设有侧卡槽63，所述盛放柜31的台阶部对应侧卡槽63位置固定有卡位条，所述卡位条插接于对应位置的侧卡槽63中。
作为本技术方案的进一步改进，盛放柜31底部设置有至少一道限位槽，所述限位槽沿盛放柜31抽拉方向延伸，所述抽拉腔12底部隔层对应于限位槽位置固定有抽拉限位条123，所述抽拉限位条123插接于盛放柜31底部的限位槽。
作为本技术方案的进一步改进，封气盖51配置有多个导气管52时，多个导气管52两两配对分成多对，每对中两个导气管的出气端分别通入至所述实验动物放置腔13，且每对中两个导气管的出气端之间连通有管路，每个管路中间分别旁路连通有外延管53，所述外延管53端部分别连通固定有散气球54，所述管路的管壁、散气球54侧壁分别各自设置有多个用于通气的散气洞55。
与现有技术相比，本发明的有益效果：
1、该模拟颗粒物环境的实验动物用发生装置中，通过设置的引导装置将超声雾化装置产生的雾化颗粒传导到实验动物放置腔的内部，使实验动物放置腔的内部充满模拟的颗粒，使放置在实验动物放置腔中的动物吸收雾化的颗粒，保证 动物在模拟的环境中不会受到干扰，保证实验环境的稳定性，提高实验数据检测的准确性。
2、该模拟颗粒物环境的实验动物用发生装置中，设置的排泄物盛放装置对动物的排泄物进行收集，同时在排泄物盛放装置上设置的对实验动物放置腔底部进行遮挡的挡封装置，在排泄物盛放装置需要倾倒动物排泄物的时候，通过调节挡封装置的位置，将实验动物放置腔的底部遮挡密封，以便于排泄物盛放装置从抽拉腔中取出，减少因抽拉排泄物盛放装置导致的对装置内部气密性的破坏。
3、该模拟颗粒物环境的实验动物用发生装置中，在通气管上设置的管过滤装置对进出实验动物放置腔中的气体进行过滤，避免外界的气体通过通气管进入到实验动物放置腔中，影响实验动物放置腔内部的环境，从而保证实验检测出的数据的准确性。
4、该模拟颗粒物环境的实验动物用发生装置中，超声雾化装置可以满足除PM颗粒物环境模拟外的多种颗粒物环境的模拟需求，实现了集纳米颗粒物、空气中携带病毒颗粒物、粉尘及PM颗粒物等环境于一体的多环境模拟，丰富了环境模拟的种类。
附图说明
图1为本发明实施例的整体结构示意图；
图2为本发明实施例的整体剖视结构示意图；
图3为本发明实施例的整体部分剖视结构示意图；
图4为本发明实施例的整体部分剖视爆炸结构示意图；
图5为本发明实施例的实验箱剖视结构示意图；
图6为本发明实施例的上密封装置剖视结构示意图；
图7为本发明实施例的排泄物盛放装置剖视结构示意图；
图8为本发明实施例的引导装置结构示意图；
图9为本发明实施例的挡封装置剖视结构示意图；
图10为本发明实施例的管过滤装置爆炸结构示意图。
图中附图标记说明如下：
1、实验箱；11、底部送气腔；12、抽拉腔；121、上卡口；122、抽拉口；123、抽拉限位条；13、实验动物放置腔；14、通气管；15、安装口；16、测量 装置固定架；17、饮食固定板；171、放食口；18、承接条；
2、上密封装置；21、密封板；22、上端盖；23、放入口；24、连接卡条；
3、排泄物盛放装置；31、盛放柜；32、盛放腔；
4、超声雾化装置；
5、引导装置；51、封气盖；52、导气管；53、外延管；54、散气球；55、散气洞；
6、挡封装置；61、挡封板；62、落物洞；63、侧卡槽；
7、TSI检测仪；
8、颗粒物过滤装置；81、连接管；82、过滤塞；
9、盛食桶。
具体实施方式
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
在本发明的描述中，需要理解的是，术语“中心”、“纵向”、“横向”、“长度”、“宽度”、“厚度”、“上”、“下”、“前”、“后”、“左”、“右”、“竖直”、“水平”、“顶”、“底”、“内”、“外”、“顺时针”、“逆时针”等指示的方位或位置关系为基于附图所示的方位或位置关系，仅是为了便于描述本发明和简化描述，而不是指示或暗示所指的设备或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本发明的限制。
此外，术语“第一”、“第二”仅用于描述目的，而不能理解为指示或暗示相对重要性或者隐含指明所指示的技术特征的数量。由此，限定有“第一”、“第二”的特征可以明示或者隐含地包括一个或者更多个该特征。在本发明的描述中，“多个”的含义是两个或两个以上，除非另有明确具体的限定。
实施例
请参阅图1-图10所示，本发明提供了一种实验动物用颗粒物环境模拟发生装置，一种实验动物用颗粒物环境模拟发生装置，包括实验箱1，实验箱1内部被隔层隔分为上、中、下三层空间，其中最上层空间为实验动物放置腔13，最 下层空间为底部送气腔11，中间层空间为抽拉腔12。
实验箱1顶部敞开使实验动物放置腔13露出，且实验箱1顶部套盖安装有上端盖22，由上端盖22使实验箱1封闭，上端盖22的盖体设置有放入口23，用于向实验动物放置腔13中放入实验用动物，放入口23铰连有密封板21，该密封板21可完全闭合并封闭放入口23以及从放入口23中转动打开，由上端盖22、密封板21使实验箱1封闭。上端盖22的底部侧壁固定有一圈连接卡条24，密封箱1外侧壁位于连接卡条24下方位置固定有一圈承接条18，连接卡条24紧密贴合于连接卡条24并与连接卡条24通过螺钉连接。由密封板21、上端盖22、放入口23、连接卡条24共同组成上密封装置2。
上端盖22朝向实验动物放置腔13的一面固定有杀菌灯、照明灯，杀菌灯为紫外线灯，用于对实验动物放置腔13内进行杀毒，照明灯用于对实验动物放置腔13内进行照明。
实验动物放置腔13内部安装有TSI检测仪7、温度计、湿度计，其中TSI检测仪7安装于实验箱1对应于实验动物放置腔13的后侧壁开设的安装口15中，而温度计、湿度计集成为一体后，共同固定于实验动物放置腔13内壁的测量装置固定架16。
实验箱1对应于实验动物放置腔13的后侧壁还开设有多个放食口171，每个放食口171两对称侧分别固定连接有饮食固定板17，放食口171的内部安装有软橡胶材质的密封挡板，每个放食口171对应的两个饮食固定板17之间滑动连接有用于盛放动物食物和饮水的盛食桶9。
实验箱1左、右侧箱壁对应于实验动物放置腔13位置还分别设有通气管14，其中一个通气管用于进气，另一个通气管用于出气，每个通气管14分别连通安装有颗粒物过滤装置8。颗粒物过滤装置8包括连接管81、过滤塞82，其中连接管81同轴螺纹连接于对应通气管14的管端，过滤塞82设于连接管81内部并插接于通气管14内，过滤塞82内部设置用于过滤颗粒物的过滤棉花。
实验动物放置腔13和抽拉腔12之间的隔层中设有多个上下贯通所述隔层的第一落物洞，各个第一落物洞内径相同，多个第一落物洞呈等间距行列阵列分布，每个第一落物洞在无遮挡时连通实验动物放置腔13和抽拉腔12。
实验箱1左侧箱壁对应于所述抽拉腔12位置设有抽拉口122，抽拉腔12内 安装有可从抽拉口122抽出的排泄物盛放装置3，由排泄物盛放装置3和抽拉腔12构成抽屉结构。
排泄物盛放装置3的主体为与抽拉口122适配的盛放柜31，盛放柜31顶部敞口并且内部为盛放腔32，排泄物盛放装置3通过其盛放腔32承接于实验动物放置腔13、抽拉腔12之间的隔层下方。
盛放柜31顶部敞口处盖装有挡封板61，挡封板61顶面紧贴于实验动物放置腔13、抽拉腔12之间的隔层底面，实验箱1右侧箱壁对应于挡封板61右侧侧位置设有用于挡封板61推入和抽出的上卡口121，挡封板61右侧延伸至插入上卡口121内，盛放柜31左侧顶部设为台阶部用于支撑挡封板61左侧，由盛放柜31的台阶部配合上卡口共同支撑挡封板61。由此，挡封板61与上卡口121、盛放柜31顶部也构成抽屉结构，可使挡封板61能够向右从上卡口121抽出。
挡封板61中设有多个上下贯通挡封板61的第二落物洞62，多个第二落物洞62呈等间距行列阵列分布，挡封板61中的第二落物洞62与实验动物放置腔13、抽拉腔12之间隔层的第一落物洞一一对应连通，且挡封板61中每个第二落物洞62的内径，小于或等于相邻第一落物洞之间间距。由此，当挡封板61被抽动时，能够活动至第二落物洞62与第一落物洞一一对应错开，进而使挡封板61被抽动时能够活动至完全封堵住实验动物放置腔13、抽拉腔12之间隔层中的第一落物洞行列阵列。
本发明实施例中，第一落物洞的内径可以与第二落物洞62内径相同，也可以不同，但只要符合每个第二落物洞62的内径，小于或等于第二落物洞62对应的第一落物洞、对应的第一落物洞在挡封板61抽拉方向(本实施例中的左右方向)上的相邻第一落物洞之间间距，即可满足挡封板61被抽动时能够完全封堵住第一落物洞行列阵列。
挡封板61支撑于盛放柜31台阶部的左侧端面设有侧卡槽63，盛放柜31左侧的台阶部对应侧卡槽63位置固定有卡位条，卡位条插接于对应位置的侧卡槽63中。
盛放柜31底部设置有至少一道沿盛放柜31抽拉方向(本实施例中左右方向)延伸的限位槽，抽拉腔12底部隔层对应于限位槽位置固定有抽拉限位条123，抽拉限位条123插接于盛放柜31底部的限位槽。
底部送气腔11内部设置有超声雾化装置4、引导装置5，所引导装置5包括封气盖51，封气盖51内有空腔，封气盖51的空腔内安装有风机，超声雾化装置4与封气盖51集成一体后安装于底部送气腔11底部开设的开孔中，超声雾化装置4的出口端与封气盖51内的空腔连通。封气盖51还配置有至少一个导气管52，导气管52进气端与封气盖51内的空腔连通，导气管52出气端上穿两层隔层后，再穿入至实验动物放置腔13，其中导气管52上穿底部送气腔11、抽拉腔12之间隔层时需避开排泄物盛放装置3。
封气盖51配置有多个导气管52时，多个导气管52两两配对分成多对，每对中两个导气管的出气端分别通入至所述实验动物放置腔13，且每对中两个导气管的出气端之间连通有管路，每个管路中间分别旁路连通有外延管53，所述外延管53端部分别连通固定有散气球54，管路的管壁、散气球54侧壁分别各自设置有多个用于通气的散气洞55。
本实施例中的实验箱1、上密封装置2和排泄物盛放装置3在使用时，通过翻转密封板21，使密封板21从放入口23上打开，将实验的动物通过放入口23放入到实验动物放置腔13的内部，使实验的动物在指定的模拟空间中生存，放置好实验动物后，将密封板21盖在放入口23上，使上密封装置2和实验箱1之间密封，保证实验动物的实验环境和外界的环境分离，提高实验检测数据的准确性，在实验动物排泄后，动物的排泄物落入到排泄物盛放装置3中，被排泄物盛放装置3收集，以方便在动物排泄物过多时，通过移动排泄物盛放装置3，将排泄物倾倒出去，以保证模拟颗粒物环境实验的正常进行。
本实施例中的引导装置5在使用时，开启超声雾化装置4，超声雾化装置4中的超声波在液体介质中产生的空化效应导致微激波的产生，将放置在超声雾化装置4中的用于实验的溶液颗粒雾化，雾化的溶液颗粒通过封气盖51中的微型风扇带动进入到导气管52中，并跟随导气管52的导管流动到实验动物放置腔13中，对实验动物放置腔13中的环境进行改变，使实验动物放置腔13内部的颗粒含量改变，实验动物在实验动物放置腔13中活动时，吸收实验动物放置腔13中的颗粒气体，免去了静脉注射、鼻腔滴注的麻烦，有效降低了实验由于环境差异造成的影响，增强模拟环境下的实验动物身体变化数据的准确性，使实验动物更具有研究意义与研究价值。
本实施例中在排泄物盛放装置3需要将动物的排泄物取出时，通过拉动挡封板61，使挡封板61和实验动物放置腔13底部的第一落物洞62交错开来，使挡封板61将实验动物放置腔13的底部密封，避免实验动物放置腔13中的气体通过落物洞62进入到抽拉腔12中，同时也避免外界的空气通过抽拉口122进入到实验动物放置腔13中，减少对装置内部气密性的破坏。
本实施例中，在实验动物放置腔13中设置的盛食桶9，用于实验的动物的饮食，保证实验动物的正常生存，同时在放食口171上设置密封橡胶板，在对盛食桶9注射途径放入食物水源后，便于放食口171的密封，同时便于控制小鼠的饮食条件，减少对装置内部气密性的破坏，同时设置的温度计、湿度计和TSI检测仪7，以保证模拟环境的稳定性与可信性。
本实施例中，上端盖22的内部安装有用于杀菌的紫外线灯和用于照明的光照灯管，在上端盖22内设置紫外线灯，用于实验前后的灭菌处理，安装光照灯管，在黑天也可以模拟不同光照对生物体的影响。
本实施例中，颗粒物过滤装置8对通过通气管14的气体进行过滤，以保证进出实验动物放置腔13的空气的纯净，保证实验检测数据检测的准确性。
以上显示和描述了本发明的基本原理、主要特征和本发明的优点。本行业的技术人员应该了解，本发明不受上述实施例的限制，上述实施例和说明书中描述的仅为本发明的优选例，并不用来限制本发明，在不脱离本发明精神和范围的前提下，本发明还会有各种变化和改进，这些变化和改进都落入要求保护的本发明范围内。本发明要求保护范围由所附的权利要求书及其等效物界定。

Claims (10)

  1. 一种实验动物用颗粒物环境模拟发生装置，包括封闭的实验箱(1)，其特征在于：所述实验箱(1)内部被隔层隔分为上、中、下三层空间，其中最上层空间为实验动物放置腔(13)，最下层空间为底部送气腔(11)，中间层空间为抽拉腔(12)，其中：
    所述实验箱(1)箱壁或箱顶对应于实验动物放置腔(13)位置设有放入口(23)，放入口(23)安装有可打开或闭合的密封板(21)；实验箱(1)箱壁对应于实验动物放置腔(13)位置还设有通气管(14)，所述通气管(14)用于向实验动物放置腔(13)内进气和放气，通气管(14)连通安装有颗粒物过滤装置(8)；
    所述实验动物放置腔(13)和抽拉腔(12)之间的隔层中设有多个上下贯通所述隔层的第一落物洞，每个第一落物洞在无遮挡时连通所述实验动物放置腔(13)和抽拉腔(12)；
    所述实验箱(1)箱壁对应于所述抽拉腔(12)一侧位置设有抽拉口(122)，所述抽拉腔(12)内安装有与抽拉口(122)适配并可从抽拉口(122)抽出的排泄物盛放装置(3)，由排泄物盛放装置(3)和抽拉腔(12)构成抽屉结构；所述排泄物盛放装置(3)内部有盛放腔(32)，排泄物盛放装置(3)顶部敞口，排泄物盛放装置(3)通过其盛放腔(32)承接于实验动物放置腔(13)、抽拉腔(12)之间的隔层下方；所述排泄物盛放装置(3)顶部敞口处盖装有挡封板(61)，所述挡封板(61)顶面紧贴于实验动物放置腔(13)、抽拉腔(12)之间的隔层底面，所述实验箱(1)箱壁对应于挡封板(61)一侧位置设有用于挡封板(61)推入和抽出的上卡口(121)，所述挡封板(61)对应于上卡口(121)的一侧延伸至插入上卡口(121)内；所述挡封板(61)中设有多个上下贯通挡封板(61)的第二落物洞(62)，挡封板(61)中的第二落物洞(62)与实验动物放置腔(13)、抽拉腔(12)之间隔层的第一落物洞一一对应连通，且挡封板(61)中每个第二落物洞(62)的内径，小于或等于第二落物洞(62)对应的第一落物洞、对应的第一落物洞在挡封板(61)抽拉方向上的相邻第一落物洞之间间距；
    所述底部送气腔(11)内部设置有超声雾化装置(4)、引导装置(5)，所述引导装置(5)包括封气盖(51)，封气盖(51)内有空腔，封气盖(51)的空腔 内安装有风机，所述超声雾化装置(4)的出口端与封气盖(51)内的空腔连通；封气盖(51)还配置有至少一个导气管(52)，导气管(52)进气端与封气盖(51)内的空腔连通，导气管(52)出气端穿出所述底部送气腔(11)后再穿入至所述实验动物放置腔(13)。
  2. 根据权利要求1所述的一种实验动物用颗粒物环境模拟发生装置，其特征在于：所述实验箱(1)顶部敞开使实验动物放置腔(13)露出，且实验箱(1)顶部套盖安装有上端盖(22)，由上端盖(22)使所述实验箱(1)封闭，所述放入口(23)设置于上端盖(22)的盖体；所述上端盖(22)的底部侧壁固定有一圈连接卡条(24)，所述密封箱(1)外侧壁位于连接卡条(24)下方位置固定有一圈承接条(18)，所述连接卡条(24)贴合于连接卡条(24)并与连接卡条(24)通过螺钉连接。
  3. 根据权利要求2所述的一种实验动物用颗粒物环境模拟发生装置，其特征在于：所述上端盖(22)朝向实验动物放置腔(13)的一面固定有杀菌灯、照明灯两者中的至少一者。
  4. 根据权利要求1所述的一种实验动物用颗粒物环境模拟发生装置，其特征在于：所述实验动物放置腔(13)内部安装有TSI检测仪(7)、温度计、湿度计三者中的至少一者。
  5. 根据权利要求1所述的一种实验动物用颗粒物环境模拟发生装置，其特征在于：所述实验箱(1)箱壁对应于实验动物放置腔(13)位置还设有放食口(171)。
  6. 根据权利要求1所述的一种实验动物用颗粒物环境模拟发生装置，其特征在于：所述通气管(14)连通安装的颗粒物过滤装置(8)包括连接管(81)、过滤塞(82)，所述连接管(81)螺纹连接通气管(14)，所述过滤塞(82)设于连接管(81)内部并插接于通气管(14)内，过滤塞(82)内部设置用于过滤颗粒物的过滤棉花。
  7. 根据权利要求1所述的一种实验动物用颗粒物环境模拟发生装置，其特征在于：所述排泄物盛放装置(3)的主体为与抽拉口(122)适配的盛放柜(31)，盛放柜(31)顶部敞口并且内部为盛放腔(32)，盛放柜(31)远离所述上卡口(121)的一侧顶部设为台阶部用于支撑所述挡封板(61)对应侧，由盛放柜(31) 的台阶部配合上卡口共同支撑所述挡封板(61)。
  8. 根据权利要求7所述的一种实验动物用颗粒物环境模拟发生装置，其特征在于：所述挡封板(61)支撑于盛放柜(31)台阶部的一侧端面设有侧卡槽(63)，所述盛放柜(31)的台阶部对应侧卡槽(63)位置固定有卡位条，所述卡位条插接于对应位置的侧卡槽(63)中。
  9. 根据权利要求7所述的一种实验动物用颗粒物环境模拟发生装置，其特征在于：所述盛放柜(31)底部设置有至少一道限位槽，所述限位槽沿盛放柜(31)抽拉方向延伸，所述抽拉腔(12)底部隔层对应于限位槽位置固定有抽拉限位条(123)，所述抽拉限位条(123)插接于盛放柜(31)底部的限位槽。
  10. 根据权利要求1所述的一种实验动物用颗粒物环境模拟发生装置，其特征在于：所述封气盖(51)配置有多个导气管(52)时，多个导气管(52)两两配对分成多对，每对中两个导气管的出气端分别通入至所述实验动物放置腔(13)，且每对中两个导气管的出气端之间连通有管路，每个管路中间分别旁路连通有外延管(53)，所述外延管(53)端部分别连通固定有散气球(54)，所述管路的管壁、散气球(54)侧壁分别各自设置有多个用于通气的散气洞(55)。
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