WO2022211638A1 - Récipient de médicament comprenant une enceinte pourvue d'un revêtement de graphène ou une enceinte en un matériau comprenant du graphène - Google Patents
Récipient de médicament comprenant une enceinte pourvue d'un revêtement de graphène ou une enceinte en un matériau comprenant du graphène Download PDFInfo
- Publication number
- WO2022211638A1 WO2022211638A1 PCT/NL2022/050189 NL2022050189W WO2022211638A1 WO 2022211638 A1 WO2022211638 A1 WO 2022211638A1 NL 2022050189 W NL2022050189 W NL 2022050189W WO 2022211638 A1 WO2022211638 A1 WO 2022211638A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- medication
- medication container
- enclosure
- graphene
- container
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims abstract description 132
- 229940079593 drug Drugs 0.000 title claims abstract description 131
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 title claims abstract description 59
- 229910021389 graphene Inorganic materials 0.000 title claims abstract description 57
- 239000000463 material Substances 0.000 title claims abstract description 26
- 239000011248 coating agent Substances 0.000 title claims abstract description 24
- 238000000576 coating method Methods 0.000 title claims abstract description 24
- 238000002347 injection Methods 0.000 claims description 25
- 239000007924 injection Substances 0.000 claims description 25
- 239000010410 layer Substances 0.000 claims description 14
- 238000004519 manufacturing process Methods 0.000 claims description 11
- 239000003708 ampul Substances 0.000 claims description 9
- 229910052751 metal Inorganic materials 0.000 claims description 7
- 239000002184 metal Substances 0.000 claims description 7
- 239000011521 glass Substances 0.000 claims description 6
- 239000004033 plastic Substances 0.000 claims description 6
- 229920003023 plastic Polymers 0.000 claims description 6
- 239000002775 capsule Substances 0.000 claims description 5
- 239000002356 single layer Substances 0.000 claims description 4
- 210000000707 wrist Anatomy 0.000 claims description 4
- 206010002198 Anaphylactic reaction Diseases 0.000 claims description 3
- 230000036783 anaphylactic response Effects 0.000 claims description 3
- 208000003455 anaphylaxis Diseases 0.000 claims description 3
- 239000000919 ceramic Substances 0.000 claims description 3
- 206010012601 diabetes mellitus Diseases 0.000 claims description 3
- 238000000034 method Methods 0.000 description 5
- 229910045601 alloy Inorganic materials 0.000 description 3
- 239000000956 alloy Substances 0.000 description 3
- 125000004429 atom Chemical group 0.000 description 3
- 238000005229 chemical vapour deposition Methods 0.000 description 3
- 238000012377 drug delivery Methods 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 229960000074 biopharmaceutical Drugs 0.000 description 2
- 239000012611 container material Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000001652 electrophoretic deposition Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
- 239000006104 solid solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000002435 venom Substances 0.000 description 2
- 231100000611 venom Toxicity 0.000 description 2
- 210000001048 venom Anatomy 0.000 description 2
- 229930182837 (R)-adrenaline Natural products 0.000 description 1
- 229930003347 Atropine Natural products 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002303 anti-venom Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 description 1
- 229960000396 atropine Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 239000002178 crystalline material Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000003618 dip coating Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 229960005139 epinephrine Drugs 0.000 description 1
- 229940015979 epipen Drugs 0.000 description 1
- 238000004299 exfoliation Methods 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 229910000765 intermetallic Inorganic materials 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 229910001092 metal group alloy Inorganic materials 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229940071643 prefilled syringe Drugs 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000004151 rapid thermal annealing Methods 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000004528 spin coating Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1468—Containers characterised by specific material properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/06—Ampoules or carpules
- A61J1/065—Rigid ampoules, e.g. glass ampoules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
Definitions
- Medication container comprising an enclosure provided with a graphene coating or an enclosure made of a material comprising graphene
- the present invention relates to a medication container for placement in a medical device, such as a single-use or reuseable medication/drug delivery device, suitable for administering a medication during use contained in the medication container, such as a pre-filled syringe, as well as a medical device comprising such a medication container, such as a wearable injection device, for instance a watch.
- a medical device such as a single-use or reuseable medication/drug delivery device, suitable for administering a medication during use contained in the medication container, such as a pre-filled syringe, as well as a medical device comprising such a medication container, such as a wearable injection device, for instance a watch.
- Medication containers are known in the art, in various forms and shapes, such as syringes, cartridges, vials, bottles, bags, capsules, ampoules, et cetera.
- a problem with such medication containers is that the “shelf life” of the medication or in a general sense the expiry date of the medication leaves a lot to be desired, in particular due to the negative influence of UV light/radiation, sunlight, daylight, heat, air pressure for example or more generally speaking relatively and/or extremely high and low temperatures capable of lowering the quality of the medication contained in the medication container.
- Injection devices comprising such medication containers are also known in the art.
- epinephrine, insulin, morphine, atropine, anti-venoms, anti-biologics, and other injections syringes like the so called Auto Injection Pens, pump patches and the “Epipen”, are widely used for treating life-threatening allergic reactions and present themselves in the form of auto-injectors with the shape of for instance a pen.
- WO 2014/096957 A2 discloses such a pen-shaped injector.
- US 2.605.765 A furthermore discloses a wrist watch with an injector mechanism.
- An object of the invention is to provide a medication container for placement in a medical device suitable for administering a medication during use contained in the medication container, as well as a medical device comprising such a medication container, such as a wearable injection device, for instance a watch, wherein degrading of the medication contained in the medication container due to UV light, sun light, daylight and relatively and/or extremely high and low temperatures can be prevented, or at least slowed down in order to extend the shelf-life, and e.g. make the primary drug container “stronger”.
- a medication container for placement in a medical device suitable for administering a medication during use contained in the medication container, wherein the medication container comprises an enclosure provided with a graphene coating on an inner and/or outer surface of the enclosure and/or wherein the enclosure is substantially made of a material comprising graphene.
- the medication container may be reusable or may be single-use.
- graphene may reinforce the rigidity/strength of the enclosure.
- Graphene also has anti-corrosive properties, as well as antibacterial and antiviral properties.
- graphene may relate to graphene as such, but may also broadly relate to “graphene-based, graphite-based or carbon-based”.
- Graphene can be synthesized by numerous methods including micromechanical cleavage, liquid-phase exfoliation, chemical vapor deposition (CVD), and chemical methods.
- An embodiment relates to an aforementioned medication container, wherein the medication container is a medication space of a syringe, a vial, a cartridge, a medication bottle, a medication bag, an ampoule, a capsule or a medication container in an inhalation device, drug delivery device or drug delivery patch (pump).
- the medication container is a medication space of a syringe, a vial, a cartridge, a medication bottle, a medication bag, an ampoule, a capsule or a medication container in an inhalation device, drug delivery device or drug delivery patch (pump).
- An embodiment relates to an aforementioned medication container, comprising a medication for administration by the medical device.
- An embodiment relates to an aforementioned medication container, wherein the medication concerns a medication intended for the treatment of conditions requiring immediate treatment with the medication, such as anaphylaxis or diabetes, biological poison, venom and toxic gasses, and other first aid conditions.
- a medication intended for the treatment of conditions requiring immediate treatment with the medication such as anaphylaxis or diabetes, biological poison, venom and toxic gasses, and other first aid conditions.
- An embodiment relates to an aforementioned medication container, wherein the graphene coating is a single layer, bilayer or multilayer graphene coating.
- a “layer” in this respect refers to a layer with a thickness of a single atom, usually 0.35 nm.
- An embodiment relates to an aforementioned medication container, wherein the graphene coating has a thickness of 1 - 50 layers, preferably 1 - 20 layers, more preferably 1 - 10 layers.
- the aforementioned graphene coating may thus have a nominal thickness of 0.35 nm - 17.5 nm, preferably 0.35 nm - 7 nm, more preferably 0.35 nm - 3.5 nm.
- An embodiment relates to an aforementioned medication container, wherein the material comprising graphene comprises a plastic, a metal and/or a ceramic, such as glass, or a combination material and future primary drug container materials yet to enter the market segment.
- the material comprising graphene comprises a plastic, a metal and/or a ceramic, such as glass, or a combination material and future primary drug container materials yet to enter the market segment.
- Another aspect of the invention relates to a medical device comprising an aforementioned medication container, wherein the medical device is suitable for administering the medication during use contained in the medication container.
- An embodiment relates to an aforementioned medical device, wherein the medical device is an injection device, such as a syringe.
- An embodiment relates to an aforementioned medical device, wherein the injection device is a wearable injection device to be worn by a person possibly requiring injection of the medication during use contained in the medication container.
- An embodiment relates to an aforementioned medical device, wherein the wearable injection device is a watch, comprising a wrist band, a display window and an injection mechanism for injection of the medication during use contained in the reusable medication container.
- the aforementioned medical device may also be attached to a wristband as such (i.e. without the watch).
- the watch, or the aforementioned medical device attached to a wristband as such may be reusable or may be single-use.
- Another aspect of the invention relates to a method for producing an aforementioned medication container, comprising the steps of: manufacturing the medication container comprising the enclosure and providing the enclosure with the graphene coating on the inner and/or outer surface of the enclosure; and/or manufacturing the enclosure with the material comprising graphene.
- the graphene coating may be deposited by various methods, including solvent-based techniques (e.g., spin coating, spray coating, dip coating, drop casting, and layer-by-layer deposition), CVD, rapid thermal annealing, and electrophoretic deposition (EPD), and other and future methods.
- solvent-based techniques e.g., spin coating, spray coating, dip coating, drop casting, and layer-by-layer deposition
- CVD chemical vapor deposition
- rapid thermal annealing atomic layer-by-layer deposition
- EPD electrophoretic deposition
- the graphene can for instance be easily mixed with various materials like plastics, polymers, and glass types lending its intra-sheet strength to the plastic matrix and making the combined material much stronger. It not only improves the strength of the material and plastic matrix but also improves resistance to chemical or thermal degradation.
- the material can also be a metal or a metal alloy.
- Graphene alloys are advantageous, because metals have good mechanical strength and elasticity, hardness, electrical conductivity, and thermal conductivity while graphene has a tensile strength of up to 130 GPa, about 200 times more than that of steel at 600 MPa.
- Graphene may be used to fill the matrix spaces, which is superior to oxide or carbide fillers, which cause a loss of conductivity to heat and electricity. With graphene filler, there is an improvement in mechanical properties while retaining excellent heat and electrical attributes. The presence of even low loads of graphene allows the final material to be significantly reinforced concerning its mechanical properties.
- a wall thickness of the medication container can thus be significantly reduced, leading to lighter medication containers, medication containers which can contain more medicine for the same volume, and/or medication that can be more easily stored and transported.
- the metal can e.g. comprise copper, tungsten, aluminium, nickel or the alike.
- the alloy may also comprise high entropy alloys (HEAs), which contain five or more different types of metal atoms in a solid solution held in a single-phase structure. The high configurational entropy holds these components in a solid solution rather than intermetallic compound formation.
- HAAs high entropy alloys
- Such HEAs have extreme resistance to corrosion, wear, and oxidation, and are very strong, and are thus highly suitable for use with a medication container.
- Graphene can also be mixed with a ceramic material, such as glass, which may provide surface hydrophobicity without sacrificing the transparency of conventional glass.
- a ceramic material such as glass
- Figures 1 and 2 illustrate several example embodiments of medication containers, as well as medical devices, such as medical patches and pumps, comprising such medication containers, wherein the medication containers comprise an enclosure provided with a graphene coating on an inner and/or outer surface of the enclosure and/or wherein the enclosure is made of a material comprising graphene.
- Figures 1 and 2 illustrate various types of medication containers 1 for placement in a medical device 18 suitable for administering a medication 19 during use contained in the medication container 1.
- the medication container 1 is provided with some form of medication temperature control or drug temperature control.
- the medication container 1 can be a medication space 2 or volume of a syringe 18, a medication bottle 3, 13, a medication bag 4, various types of ampoules 5, 6, 7, 11 , 14, 15, 16, capsules 10, or a medication container 8 in an inhalation device 20, et cetera.
- the medication container 1 could, for instance, also be a cartridge (not shown).
- the medication container comprises a highly schematically indicated enclosure 17 provided with a graphene coating on an inner and/or outer surface of the enclosure.
- the enclosure 17 could also be made of a material comprising graphene.
- Graphene is a strong and ultra-thin crystalline material consisting of a single layer of carbon atoms arranged in a honeycomb-like pattern. Graphene can thus be used to absorb or block UV light, sunlight, daylight and/or for cooling - and as the world's strongest material, can also be used to enhance the strength of other materials, for instance the material used for the enclosure 17.
- the graphene coating may be a single layer, but also a bilayer or multilayer graphene coating are conceivable.
- a “layer” in this respect refers to a layer with a thickness of a single atom, usually 0.35 nm, but may be thinner or thicker.
- the graphene coating may have a thickness of 1 - 50 layers, preferably 1 -20 layers, more preferably 1 - 10 layers.
- the graphene coating may thus have a nominal thickness of 0.35 nm - 17.5 nm, preferably 0.35 nm - 7 nm, more preferably 0.35 nm - 3.5 nm.
- the material comprising graphene may e.g. comprise a plastic, a metal and/or a ceramic, such as glass, or future medication/drug container materials or a combination (composite) material.
- the medication 19 preferably concerns a medication intended for the treatment of conditions requiring immediate treatment with the medication, such as anaphylaxis, diabetes, biologicals, venoms, gasses, etc.
- Other medications 19 are, of course, also conceivable, such as vaccines or the like.
- the injection device 18 may also be a reusable wearable injection device (not shown) to be worn by a person possibly requiring injection of the medication 19 during use contained in the medication container 1, 2, such as disclosed in patent publication WO 2016/064266 A2 by the present Applicant, the contents of which are incorporated by reference in the present patent application.
- the wearable injection device preferably is a watch or a smart watch (not shown), comprising a wrist band, a display window and an injection mechanism for injection of the medication 19 during use contained in the medication container, such as disclosed in Dutch patent application NL2024968 and PCT patent application PCT/NL2021/050106 by the present Applicant, the contents of which are incorporated by reference in the present patent application.
- the medication container 1 may be manufactured by a method for producing such a medication container, comprising the steps of: manufacturing the medication container 1 comprising the enclosure 17 and providing the enclosure with the graphene coating on the inner and/or outer surface of the enclosure 17; and/or manufacturing the enclosure 17 with the material comprising graphene.
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
L'invention concerne un récipient de médicament (1; 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16) destiné à être placé dans un dispositif médical (18) approprié pour l'administration d'un médicament (19) pendant l'utilisation contenue dans le récipient de médicament, le récipient de médicament comprenant une enceinte (17) pourvue d'un revêtement de graphène sur une surface interne et/ou externe de l'enceinte et/ou l'enceinte (17) étant constituée d'un matériau comprenant du graphène.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL2027911 | 2021-04-02 | ||
NL2027911 | 2021-04-02 |
Publications (1)
Publication Number | Publication Date |
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WO2022211638A1 true WO2022211638A1 (fr) | 2022-10-06 |
Family
ID=81326754
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/NL2022/050189 WO2022211638A1 (fr) | 2021-04-02 | 2022-04-04 | Récipient de médicament comprenant une enceinte pourvue d'un revêtement de graphène ou une enceinte en un matériau comprenant du graphène |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2022211638A1 (fr) |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2605765A (en) | 1947-06-05 | 1952-08-05 | Kollsman Paul | Automatic syringe |
WO2014096957A2 (fr) | 2012-11-09 | 2014-06-26 | Iinjec Technologies Inc. | Dispositif et procédé d'administration de fluide |
WO2015105937A1 (fr) * | 2014-01-09 | 2015-07-16 | Valeritas, Inc. | Piston |
WO2016064266A2 (fr) | 2014-10-20 | 2016-04-28 | Witteman Amber Helène Tamara | Dispositif d'injection pouvant être porté sur soi conçu pour être fixé de manière portable à une partie de corps, en vue d'injecter un médicament à travers la peau de la partie de corps dans un état portable sur soi |
US20170296706A1 (en) * | 2016-04-14 | 2017-10-19 | Lockheed Martin Corporation | Methods for in vivo and in vitro use of graphene and other two-dimensional materials |
US10786431B2 (en) * | 2012-11-30 | 2020-09-29 | Corning Incorporated | Glass containers with delamination resistance and improved damage tolerance |
NL2024968B1 (en) | 2020-02-21 | 2021-10-06 | Amber Helene Tamara Witteman | Injection devices for wearable devices |
-
2022
- 2022-04-04 WO PCT/NL2022/050189 patent/WO2022211638A1/fr active Application Filing
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2605765A (en) | 1947-06-05 | 1952-08-05 | Kollsman Paul | Automatic syringe |
WO2014096957A2 (fr) | 2012-11-09 | 2014-06-26 | Iinjec Technologies Inc. | Dispositif et procédé d'administration de fluide |
US10786431B2 (en) * | 2012-11-30 | 2020-09-29 | Corning Incorporated | Glass containers with delamination resistance and improved damage tolerance |
WO2015105937A1 (fr) * | 2014-01-09 | 2015-07-16 | Valeritas, Inc. | Piston |
WO2016064266A2 (fr) | 2014-10-20 | 2016-04-28 | Witteman Amber Helène Tamara | Dispositif d'injection pouvant être porté sur soi conçu pour être fixé de manière portable à une partie de corps, en vue d'injecter un médicament à travers la peau de la partie de corps dans un état portable sur soi |
US20170296706A1 (en) * | 2016-04-14 | 2017-10-19 | Lockheed Martin Corporation | Methods for in vivo and in vitro use of graphene and other two-dimensional materials |
NL2024968B1 (en) | 2020-02-21 | 2021-10-06 | Amber Helene Tamara Witteman | Injection devices for wearable devices |
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