WO2022211610A2 - Composition for medical or cosmetic use containing lipids from seeds of brassica rapa subsp rapa - Google Patents

Composition for medical or cosmetic use containing lipids from seeds of brassica rapa subsp rapa Download PDF

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Publication number
WO2022211610A2
WO2022211610A2 PCT/MA2022/050003 MA2022050003W WO2022211610A2 WO 2022211610 A2 WO2022211610 A2 WO 2022211610A2 MA 2022050003 W MA2022050003 W MA 2022050003W WO 2022211610 A2 WO2022211610 A2 WO 2022211610A2
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composition
medical
skin
cosmetic use
rapa
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PCT/MA2022/050003
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French (fr)
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WO2022211610A3 (en
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Lotfi AARAB
Soukaina LAARAJ
Ibtissam OUAHIDI
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Université Sidi Mohamed Ben Abdellah
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/75—Anti-irritant

Definitions

  • composition for medical or cosmetic use including lipids from the seeds of Brassica Rapa subsp rapa
  • the present invention relates to the cosmetic and medical field, and more particularly the invention relates to a composition for medical or cosmetic use including lipids from the seeds of Brassica Rapa subsp rapa
  • UVA, UVB and UVC Ultraviolet rays
  • UVA rays are electromagnetic radiation provided by the sun's rays. Their low wavelengths give them stronger energies, even causing burns on the human body. While UVA rays are beneficial by increasing the production of vitamin D3, UVB rays are more dangerous because their energies can cause burns up to 3rd degree in addition to skin aging and skin cancer.
  • Effects of repeated exposures include aging and skin cancer. There is a strong causal link between skin cancer and prolonged exposure to UV rays from the sun. Excessive exposure to ultraviolet radiation is associated with various types of skin cancer, sunburn, premature aging of the skin, as well as cataracts and other eye diseases.
  • UVC rays pose the greatest risk. These rays, emitted by the sun, are absorbed by the ozone layer of the atmosphere before reaching the surface of the Earth. Mid-wavelength UVB rays cause burning, erythema (redness of the skin) and darkening of the skin; prolonged exposures increase the risk of cancer and skin. Long-wavelength UVA radiation accounts for up to 95% of the ultraviolet radiation that reaches the Earth's surface. Although UVA rays are less intense than UVB rays, they are more present and can reach the deeper layers of the skin, therefore the connective tissue and blood vessels, thus causing premature aging.
  • Physical sunscreens of the zinc oxide and titanium dioxide type are opaque, often greasy products that block (totally or partially) UVA and UVB rays.
  • Chemical sunscreens can absorb both UVA rays and UVB rays.
  • Broad-spectrum sunscreens are made up of physical and chemical filters to protect against both types of UV rays.
  • Sunscreens are rated on their sun protection factor (SPF), which is an index of protection against skin erythema (redness of the skin). The higher the SPF of a product or sunscreen, the more complete the protection and the minor the consequences.
  • SPDF sun protection factor
  • the first sunscreen is said to have been invented by Franz Greiter in 1938; the 'Glacier Cream' product became the basis of the Piz Buin company, which took its name from the region of Switzerland that inspired Greiter's cream. Greiter in 1962 also developed the concept of a sun protection factor, which has become the worldwide standard for measuring the effectiveness of sunscreens when applied at a uniform rate of 2 milligrams per square centimeter (mg/cm2) .
  • Vegetable oils are composed mainly of triglycerides of different fatty acids, along with mono- and diglycerides and free fatty acids. In small amounts, they may contain phospholipids, sterols, terpenoids and fat-soluble vitamins (Karak, 2012, ImVegetable Oil-Based Polymers. Woodhead Publishing Limited, pp. 54-95.).
  • oils can provide skin protection against reactive oxygen species (ROS) (Tehranifar et al., 2011, Ind. Crop. Prod 34,1523-1527.; Dhavamani et al., 2014, Food Chem. 164, 551-555).
  • ROS reactive oxygen species
  • oils may also contain anti-cancer and anti-inflammatory compounds (Saha and Ghosh, 2011, Chem-Biol. Interact. 190, 109-120; Cicerale et al., 2012, Curr. Opin. Biotech. 23, 129- 135.).
  • vegetable oils are used as moisturizers and emollients by increasing skin hydration (Saraf et al., 2010, Pharma. Res. 2, 146-451).
  • Photoprotective cosmetics use synthetic sunscreens or UV filters, which absorb, reflect or scatter both UVA and UVB rays to a certain extent, in order to protect the skin against the harmful effects of the sun's rays.
  • Adding antioxidants to photoprotective formulations may also benefit the skin by neutralizing ROS generated by residual UV rays that have not been filtered by sunscreen and have reached the skin (Wang et al., 2011, J. Am. Acad. Dermatol. 65, 525-530; Chiari et al., 2014, Ind. Crop. Prod. 52, 389-393).
  • rice bran oil has been found to have a protective role in UV light-induced lipid peroxidation (Patel and Naik, 2004, J. Sci. Ind. Res.
  • sesamol from sesame oil offers powerful photoprotection for lymphocytes against UVB-induced lipid peroxidation (Prasad et al., 2005, Environ. Toxicol. Phar. 20, 1-5).
  • Compounds in pomegranate seed oil inhibit UVB-induced skin damage (Melo et al., 2014, J.Human Nutr. Food Sci. 2, 1024) and the tocopherol present in pomegranate seed oil wheat protects cell membranes against light-induced damage (Korac and Khambholja, 2011, Pharmacogn. Rev. 5, 164-173).
  • Brassicaceae forms are grown for food all over the world. Due to their anti-inflammatory and antibacterial properties, these plants and their seeds were widely used in traditional medicine to relieve symptoms associated with gastrointestinal disorders as well as the treatment of wounds and mastitis (anti-inflammatory effect).
  • Vegetable oils are an essential part of human and animal nutrition because they are a source of essential unsaturated fatty acids often recommended by dieticians. Oil is a major component of the seeds of plants in the Brassicaceae (Cruciferae) family ranging from 20 to 40% oil. The oil of some Brassicaceae is considered undesirable for human nutrition due to the high amount of antinutrient compounds. However, the oil may have benefits other than nutritional but beneficial to human health.
  • US patent 8337820 and US patent 821655 both describe a formulation to protect the skin from UV rays, in which the main ingredients are titanium dioxide and 5-hydroxy-tryptophan and Griffonia simplicifolia extract. Also known in the art of sun protection compositions are compositions containing extracts of green tea, Aloe vera, calendula, chamomile and rosemary.
  • US Patent 7731942 describes sunscreen products containing caffeine, seaweed extract, pineapple extract and other ingredients.
  • US patent 6524599 describes a composition for the care of the skin, nails and hair in which the composition contains milk thistle (Silibum marianum) with soy protein and alpha tocopherol.
  • US patent 5876736 describes a skin care composition for revitalizing the skin and comprising plant polysaccharides among various other ingredients.
  • US patent 2011/0229538 describes a total skin care composition (as sunscreen) containing a combination of ascorbic acid and herbal extracts include red clover extract, ginseng and St. John's wort among others.
  • This oil has UV absorbing properties giving it the ability to be used as a sunscreen in any sunscreen formulation alone or in combination with physical filters. Its oily nature allows it to be easily incorporated into all formulations based on synthetic lipid substances (paraffin oil, vaseline, etc.) or natural such as shea butter or other.
  • This oil also has significant antioxidant properties. This allows it to reduce the reactions of ROS products from cell metabolism or sunlight. Its antioxidant potential can reduce oxidative damage from sunlight and maintain the skin's elasticity. This is an effective way to fight skin aging.
  • This oil has an immunosuppressive and therefore anti-inflammatory action which allows it to fight against normal irritations or those induced by the sun's rays.
  • sunscreens helps protect the skin against the short-term and long-term effects in particular, oxidation, burns, inflammation due to solar UV. These sunscreens are mostly made of several chemical molecules that can induce undesirable reactions in users.
  • the object of the invention is to provide a composition for medical or cosmetic use including lipids from the seeds of Brassica Rapa subsp rapa which are a non-toxic natural product with protection against oxidation, burns, drying out and inflammation. skin. These characteristics make these lipids useful as a sunscreen thanks to their ultraviolet absorption, anti-oxidant, and anti-inflammatory properties.
  • the oily property of lipids provides hydration and limits cutaneous evapo-transpiration, as well as in the treatment of inflammatory reactions of the skin, irritation, allergy, eczema, etc. to reduce inflammatory reactions.
  • Figures 1 and 2 report UV absorption results showing that Brassica Rapa subsp rapa seed lipids have UVA and UVB ray absorption properties.
  • Figure 3 shows the antioxidant effect of Brassica Rapa subsp rapa seed oil compared to BHT and Ascorbic acid
  • Figures 4 and 5 show the effect of Brassica Rapa subsp rapa seed lipids on immune system B and T cell proliferation.
  • the object of the present invention relates to a new composition for medical or cosmetic use comprising lipids from the seeds of Brassica Rapa subsp rapa either alone or in combination with another substance.
  • the composition that is the subject of the invention comprises ultraviolet A and B absorption powers which give them the property of photoprotection of the skin against ultraviolet rays. of the sun. These ultraviolet absorbing powers provide protection of approximately 90% of UV rays in Ultraviolet B and up to 75% in Ultraviolet A.
  • the oily properties of the lipids provide hydration and limit cutaneous evapo-perspiration.
  • composition has powers that allow it to have several medical and / or cosmetic applications, we cite the following properties:
  • Antioxidant powers which give them the property of being used as anti-ageing, anti-aging, anti-wrinkle substances.
  • Anti-irritant powers which give them the ability to fight against various skin irritations such as the sun's rays.
  • composition that is the subject of the invention also has the advantage of retaining all the aforementioned properties in any aqueous or oily liquid or solid, total or partial base.
  • Figures 1 and 2 report UV absorption results showing that Brassica Rapa subsp rapa seed lipids have UVA and UVB ray absorption properties. Absorptions are stronger in UVB than in UVA. At 5mg/ml there are significant absorptions of 1.23 and 1.86 in UVA and UVB respectively, i.e. more than 90% of the maximum of UVB rays.
  • Figure 3 shows that oxidation and the products released during these reactions at the cellular level can be the cause of cell failure and disruption of metabolic and enzymatic pathways.
  • Figure 3 shows that the lipids of the dt Brassica Rapa subsp rapa seeds possess antioxidant activities which can fight against the oxidation caused at the level of the cells of the skin by the solar Ultraviolet rays. This antioxidant capacity of these lipids increases according to the concentration. With even 0.1%, an antioxidant effect of about 30% is observed. It can be seen that the maximum is 83% for the 5% concentration.
  • This antioxidant effect of Brassica Rapa subsp rapa seed lipids is similar to that recorded with substances already known for their antioxidant power such as BHT or ascorbic acid (vitamin C).
  • Figures 4 and 5 show the effect of Brassica Rapa subsp rapa seed lipids on immune system B and T cell proliferation.
  • the results obtained clearly indicate that the addition of lipids from the seeds of Brassica Rapa subsp rapa reduces the multiplication of B lymphocytes by more than 50% and the multiplication of T lymphocytes by almost 30%. This indicates an immunosuppressive and therefore anti-inflammatory effect. since immunosuppression on these lymphocytes will block the synthesis of cytokines and inflammation mediators generally secreted by these cells.
  • This effect of Brassica Rapa subsp rapa seed lipids in reducing inflammation mediators will reduce the inflammatory effects of the sun's rays on the skin by reducing the immune reactions in the area that receives the sun's rays.
  • the characteristics of a sunscreen is any composition capable of reducing the effects of solar rays: UV rays, inflammation and tissue oxidation.
  • the lipids of the seeds of Brassica Rapa subsp rapa have these three properties, these lipids are antioxidants, UV photo-absorbents and anti-inflammatory. This justifies the lipids of the seeds of Brassica Rapa subsp rapa their use as a sunscreen to protect against the harmful effects of the sun's rays.
  • the anti-inflammatory properties of the lipids of the seeds of Brassica Rapa subsp rapa allow them to be used in the treatment of inflammatory reactions of the skin, irritation, allergy, eczema, etc. to reduce inflammatory reactions.
  • non-toxic lipids can be used in the fight against skin dryness through their emollient properties.
  • the composition can be applied in the cosmetic and/or medical field as a sunscreen to protect against the harmful effects of the sun's rays as well as the treatment of inflammatory reactions of the skin, irritation, allergy, eczema, etc. .etc. to reduce inflammatory reactions.

Abstract

The present invention relates to the development and production of a novel composition containing lipids from seeds of Brassica Rapa subsp rapa for treating or protecting the skin, in the form of a cream, in a spray, or for application to the face. These lipids from seeds of Brassica Rapa subsp rapa have antioxidant, light-absorbing and anti-inflammatory properties which enable them to protect the skin from ultraviolet radiation and to reduce ultraviolet radiation damage to the skin without toxic effects or side effects. The lipids from seeds of Brassica Rapa subsp rapa, quickly absorbed by the skin, also afford protection against dryness and irritation while nourishing the skin by means of the lipid constituents.

Description

Titre : Composition à usage médical ou cosmétique incluant des lipides des graines de Brassica Rapa subsp rapa Title: Composition for medical or cosmetic use including lipids from the seeds of Brassica Rapa subsp rapa
Description Description
■ Domaine technique ■ Technical area
La présente invention touche le domaine cosmétique et médical, et plus particulièrement l’invention concerne une composition à usage médical ou cosmétique incluant des lipides des graines de Brassica Rapa subsp rapa The present invention relates to the cosmetic and medical field, and more particularly the invention relates to a composition for medical or cosmetic use including lipids from the seeds of Brassica Rapa subsp rapa
■ Description de l'état de l’art antérieur ■ Description of the prior art
Les rayons Ultraviolets (UVA, UVB et UVC) sont des rayonnements électromagnétiques apportés par les rayons solaires. Leurs faibles longueurs d'onde leurs confèrent de plus fortes énergies allant jusqu'à provoquer des brûlures sur le corps humain. Si les rayons UVA sont bénéfiques en augmentant la production de la vitamine D3, les UVB sont plus dangereux car leurs énergies peuvent provoquer des brûlures pouvant atteindre le 3ème degré en plus du vieillissement de la peau et des cancers cutanés. Ultraviolet rays (UVA, UVB and UVC) are electromagnetic radiation provided by the sun's rays. Their low wavelengths give them stronger energies, even causing burns on the human body. While UVA rays are beneficial by increasing the production of vitamin D3, UVB rays are more dangerous because their energies can cause burns up to 3rd degree in addition to skin aging and skin cancer.
Parmi les effets des expositions répétées (effets chroniques), on note le vieillissement et le cancer de la peau. On observe un lien causal important entre le cancer de la peau et une exposition prolongée aux rayons UV du soleil. Une exposition excessive au rayonnement ultraviolet est associée à différents types de cancers de la peau, à des coups de soleil, au vieillissement prématuré de la peau, de même qu'à des cataractes et à d'autres maladies oculaires. Effects of repeated exposures (chronic effects) include aging and skin cancer. There is a strong causal link between skin cancer and prolonged exposure to UV rays from the sun. Excessive exposure to ultraviolet radiation is associated with various types of skin cancer, sunburn, premature aging of the skin, as well as cataracts and other eye diseases.
Les rayons UVC de courte longueur d'onde présentent le plus grand risque. Ces rayons, émis par le soleil, sont absorbés par la couche d'ozone de l'atmosphère avant d'atteindre la surface de la Terre. Les rayons UVB de longueurs d'onde moyennes causent des brûlures, de l'érythème (rougeur de la peau) et le brunissement de la peau; des expositions prolongées augmentent le risque de cancer et de la peau. Le rayonnement UVA de grande longueur d'onde représente jusqu'à 95 % du rayonnement ultraviolet qui atteint la surface de la Terre. Bien que les UVA soient moins intenses que les UVB, ils sont plus présents et peuvent atteindre les couches plus profondes de la peau, donc le tissu conjonctif et les vaisseaux sanguins, entraînant ainsi un vieillissement prématuré. Les écrans solaires physique du type oxyde de zinc et dioxyde de titane sont des produits opaques, souvent graisseux, qui arrêtent (totalement ou partiellement) les rayons UVA et UVB. Les écrans solaires chimiques peuvent absorber les rayons UVA et les rayons UVB. Les écrans solaires assurant une protection à large spectre sont formés de filtres physiques et chimiques de manière à protéger contre ces deux types de rayons UV. Short-wavelength UVC rays pose the greatest risk. These rays, emitted by the sun, are absorbed by the ozone layer of the atmosphere before reaching the surface of the Earth. Mid-wavelength UVB rays cause burning, erythema (redness of the skin) and darkening of the skin; prolonged exposures increase the risk of cancer and skin. Long-wavelength UVA radiation accounts for up to 95% of the ultraviolet radiation that reaches the Earth's surface. Although UVA rays are less intense than UVB rays, they are more present and can reach the deeper layers of the skin, therefore the connective tissue and blood vessels, thus causing premature aging. Physical sunscreens of the zinc oxide and titanium dioxide type are opaque, often greasy products that block (totally or partially) UVA and UVB rays. Chemical sunscreens can absorb both UVA rays and UVB rays. Broad-spectrum sunscreens are made up of physical and chemical filters to protect against both types of UV rays.
Les écrans de protection sont évalués en fonction de leur facteur de protection solaire (SPF), qui est un indice de protection contre l'érythème de la peau (rougeur de la peau). Plus le SPF d'un produit ou d'un écran solaire est élevé plus la protection est complète et les conséquences mineures. Exemple : Un écran solaire ayant un SPF 30 peut absorber jusqu'à 95% des rayons UV. Sunscreens are rated on their sun protection factor (SPF), which is an index of protection against skin erythema (redness of the skin). The higher the SPF of a product or sunscreen, the more complete the protection and the minor the consequences. Example: A sunscreen with SPF 30 can absorb up to 95% of UV rays.
Le premier écran solaire aurait été inventé par Franz Greiter en 1938 ; le produit 'Glacier Cream' est devenu la base de la société Piz Buin, qui a pris son nom de la région de Suisse qui a inspiré la crème de Greiter. Greiter en 1962 a également développé le concept d'un facteur de protection solaire, qui est devenu la norme mondiale pour mesurer l'efficacité des écrans solaires lorsqu'ils sont appliqués à un taux uniforme de 2 milligrammes par centimètre carré (mg / cm2). The first sunscreen is said to have been invented by Franz Greiter in 1938; the 'Glacier Cream' product became the basis of the Piz Buin company, which took its name from the region of Switzerland that inspired Greiter's cream. Greiter in 1962 also developed the concept of a sun protection factor, which has become the worldwide standard for measuring the effectiveness of sunscreens when applied at a uniform rate of 2 milligrams per square centimeter (mg/cm2) .
Il existe deux types d'écrans solaires : There are two types of sunscreens:
*Bloqueurs physiques réfléchissant les rayons ultraviolets du soleil et contiennent l'un des deux ingrédients actifs, l'oxyde de zinc ou le dioxyde de titane. *Physical blockers that reflect the sun's ultraviolet rays and contain one of two active ingredients, zinc oxide or titanium dioxide.
*Absorbeurs chimiques contenant des produits chimiques qui absorbent les rayons ultraviolets du soleil. Parmi eux, on trouve l'acide aminobenzoïque, l'avobenzone, l'octisalate, l'octocrylène et l'oxybenzone. *Chemical absorbers contain chemicals that absorb ultraviolet rays from the sun. Among them are aminobenzoic acid, avobenzone, octisalate, octocrylene and oxybenzone.
Le marché mondiale des écrans solaires s'évaluent à plus de 10 milliards de dollar-USA dont la part des crèmes à base de produits naturels à base d'extraits de plantes en particulier les huiles ne cesse d'augmenter et va bientôt se situer vers 50% du marché dans les années à venir. Ces dernières années, il y a une demande croissante de produits naturels (surtout d'origine végétale) dans tous les secteurs de la vie. Dans le cosmétique, les huiles végétales, qui sont des ressources renouvelables abondantes et facilement disponible, suscitent un grand intérêt en tant que matières premières dans le développement de matières naturelles et cosmétiques écologiques (Balboa et al., 2014, Ind. Crop. Prod. 58, 104-110.; Lubbe etVerpoortea, 2011, Ind. Crop. Prod. 34, 785-801). Les huiles végétales sont composées principalement de triglycérides de différents acides gras, accompagné de mono- et diglycérides et d'acides gras libres. Dans de petites quantités, ils peuvent contenir des phospholipides, des stérols, des terpénoides et des vitamines liposolubles (Karak, 2012, ImVegetable Oil- Based Polymers. Woodhead Publishing Limited, pp. 54-95.).The world market for sunscreens is estimated at more than 10 billion US dollars, of which the share of creams based on natural products based on plant extracts, in particular oils, is constantly increasing and will soon be around 50% of the market in the years to come. In recent years, there has been a growing demand for natural products (especially of plant origin) in all areas of life. In cosmetics, vegetable oils, which are abundant and easily available renewable resources, are attracting great interest as raw materials in the development of natural materials and ecological cosmetics (Balboa et al., 2014, Ind. Crop. Prod. 58, 104-110.; Lubbe and Verpoortea, 2011, Ind. Crop. Prod. 34, 785-801). Vegetable oils are composed mainly of triglycerides of different fatty acids, along with mono- and diglycerides and free fatty acids. In small amounts, they may contain phospholipids, sterols, terpenoids and fat-soluble vitamins (Karak, 2012, ImVegetable Oil-Based Polymers. Woodhead Publishing Limited, pp. 54-95.).
Par leurs composés antioxydants naturels comme les tocols, les terpènes, les caroténoïdes, les flavonoïdes et les polyphénols, les huiles peuvent fournir une protection cutanée contre l'oxygène réactif espèces (ROS) (Tehranifar et al., 2011, Ind. Crop. Prod. 34,1523-1527.; Dhavamani ét al., 2014, Food Chem. 164, 551-555). En effet, les ROS sont les principaux sous- produits naturels du métabolisme oxydatif et des rayons solaires induisant des dommages oxydatifs cellulaires conduisant au processus de vieillissement (Carocho et Ferreira, 2013, Toxicol. 51, 15-25.; Chen et al., 2012, J. Am. Acad. Dermatol. 67, 1013-1024). Ces huiles peuvent contenir également des composés anti-cancéreux et anti-inflammatoire (Saha et Ghosh, 2011, Chem-Biol. Interact. 190, 109-120; Cicerale et al., 2012, Curr. Opin. Biotech. 23, 129- 135.). Dans les formulations cosmétiques, les huiles végétales sont utilisées comme hydratants et émollients en augmentant l'hydratation de la peau (Saraf et al., 2010, Pharma. Res. 2, 146- 451). Through their natural antioxidant compounds like tocols, terpenes, carotenoids, flavonoids and polyphenols, oils can provide skin protection against reactive oxygen species (ROS) (Tehranifar et al., 2011, Ind. Crop. Prod 34,1523-1527.; Dhavamani et al., 2014, Food Chem. 164, 551-555). Indeed, ROS are the main natural by-products of oxidative metabolism and sunlight inducing cellular oxidative damage leading to the aging process (Carocho and Ferreira, 2013, Toxicol. 51, 15-25.; Chen et al., 2012, J. Am. Acad. Dermatol. 67, 1013-1024). These oils may also contain anti-cancer and anti-inflammatory compounds (Saha and Ghosh, 2011, Chem-Biol. Interact. 190, 109-120; Cicerale et al., 2012, Curr. Opin. Biotech. 23, 129- 135.). In cosmetic formulations, vegetable oils are used as moisturizers and emollients by increasing skin hydration (Saraf et al., 2010, Pharma. Res. 2, 146-451).
Les produits cosmétiques photoprotecteurs utilisent des écrans solaires synthétiques ou Les filtres UV, qui absorbent, réfléchissent ou diffusent dans une certaine mesure les rayons UVA et UVB, afin de protéger la peau contre les effets nocifs effets des rayons du soleil. Photoprotective cosmetics use synthetic sunscreens or UV filters, which absorb, reflect or scatter both UVA and UVB rays to a certain extent, in order to protect the skin against the harmful effects of the sun's rays.
L'Ajout d'antioxydants aux formulations photoprotectrices peuvent également être bénéfiques pour la peau en neutralisant les ROS générés par les rayons UV résiduels qui n'ont pas été filtrés par la crème solaire et ont atteint la peau (Wang et al., 2011, J. Am. Acad. Dermatol. 65, 525- 530; Chiari et al., 2014, Ind. Crop. Prod. 52, 389-393). Par exemple, On a découvert que l'huile de son de riz avait un rôle protecteur dans la peroxydation lipidique induite par la lumière UV (Patel et Naik, 2004, J. Sci. Ind. Res. 63, 569-578.), que le sésamol issu de l'huile de sésame offre une puissante photoprotection pour lymphocytes contre la peroxydation lipidique induite par les UVB (Prasad et al., 2005, Environ. Toxicol. Phar. 20, 1-5). Les composés de l'huile de pépins de grenade inhibent les lésions cutanées induites par les UVB (Melo et al., 2014, J.Human Nutr. Food Sci. 2, 1024) et le tocophérol présent dans le l'huile du germe de blé protège les membranes cellulaires contre les dommages induits par la lumière (Korac et Khambholja, 2011, Pharmacogn. Rev. 5, 164-173). En outre, des études in vitro ont démontré la capacité du caroténoïdes, que l'on trouve dans l'huile de racine de carotte, pour protéger les fibroblastes contre les mutations de l'ADN mitochondrial induites par l'irradiation UV (Zussman et al., 2010, J. Am. Acad. Dermatol. 63, 507-525). Adding antioxidants to photoprotective formulations may also benefit the skin by neutralizing ROS generated by residual UV rays that have not been filtered by sunscreen and have reached the skin (Wang et al., 2011, J. Am. Acad. Dermatol. 65, 525-530; Chiari et al., 2014, Ind. Crop. Prod. 52, 389-393). For example, rice bran oil has been found to have a protective role in UV light-induced lipid peroxidation (Patel and Naik, 2004, J. Sci. Ind. Res. 63, 569-578.), that sesamol from sesame oil offers powerful photoprotection for lymphocytes against UVB-induced lipid peroxidation (Prasad et al., 2005, Environ. Toxicol. Phar. 20, 1-5). Compounds in pomegranate seed oil inhibit UVB-induced skin damage (Melo et al., 2014, J.Human Nutr. Food Sci. 2, 1024) and the tocopherol present in pomegranate seed oil wheat protects cell membranes against light-induced damage (Korac and Khambholja, 2011, Pharmacogn. Rev. 5, 164-173). In addition, in vitro studies have demonstrated the ability of carotenoids, found in carrot root oil, to protect fibroblasts against mitochondrial DNA mutations induced by UV irradiation (Zussman et al., 2010, J. Am. Acad. Dermatol. 63, 507-525).
De plus, certaines huiles végétales trouvées dans la littérature sont considérées comme capables de bloquer la lumière UV, l'huile de sésame est censée résister à 30% des rayons UV, tandis que la noix de coco, l'arachide, l'olive et les graines de coton leurs huiles bloquent environ 20% (Korac et Khambholja, 2011, Pharmacogn. Rev. 5, 164-173 '). Additionally, some vegetable oils found in the literature are said to be able to block UV light, sesame oil is said to be resistant to 30% of UV rays, while coconut, peanut, olive and cottonseed their oils block about 20% (Korac and Khambholja, 2011, Pharmacogn. Rev. 5, 164-173').
La famille des Brassicacées The Brassicaceae family
Plus de 20 variétés de Brassicacées sont connues actuellement dont un grand nombre est originaire de la région méditerranéenne et du sud-ouest de l'Europe. Cependant, aujourd'hui, les formes des Brassicacées sont cultivées pour la nourriture partout dans le monde. En raison de leurs propriétés anti-inflammatoires et antibactériennes, ces plantes ainsi que leurs graines étaient largement utilisées en médecine traditionnelle pour soulager les symptômes associés aux troubles gastro-intestinaux ainsi que le traitement des plaies et des mammites (effet anti- inflammatoire). More than 20 varieties of Brassicaceae are currently known, many of which originate from the Mediterranean region and southwestern Europe. However, today, Brassicaceae forms are grown for food all over the world. Due to their anti-inflammatory and antibacterial properties, these plants and their seeds were widely used in traditional medicine to relieve symptoms associated with gastrointestinal disorders as well as the treatment of wounds and mastitis (anti-inflammatory effect).
Les huiles végétales sont un élément indispensable de l'alimentation humaine et animale car elles sont une source d'acides gras insaturés essentiels et souvent recommandés par les diététiciens. L'huile est une principale composante des graines des plantes de la famille des Brassicacées (Crucifères) allant de 20 à 40% d'huile. L'huile de certaines Brassicacées est considérée comme indésirable pour la nutrition humaine en raison de la quantité élevée en composés antinutritionnels. Cependant, l'huile peut présenter des avantages autre que nutritionnels mais bénéfiques à la santé humaine. Vegetable oils are an essential part of human and animal nutrition because they are a source of essential unsaturated fatty acids often recommended by dieticians. Oil is a major component of the seeds of plants in the Brassicaceae (Cruciferae) family ranging from 20 to 40% oil. The oil of some Brassicaceae is considered undesirable for human nutrition due to the high amount of antinutrient compounds. However, the oil may have benefits other than nutritional but beneficial to human health.
Plusieurs brevets ont relaté le pouvoir antioxydant de certaines espèces de Brassicacés pour divers utilisation : Several patents have reported the antioxidant power of certain species of Brassicaceae for various uses:
*des extraits aqueux de la plante Brassica oleracea (espèce asiatique) ont été breveté comme Antioxydant pour protéger les aliments (JP2004180578 A, 2002) ou des extraits des plantes (de 7 espèces de brassicacés) ont été brevetés comme antioxydantes pour des utilisations de prévention ou traitement des maladies oculaires (DE102009058325A1, 2009)*aqueous extracts of the plant Brassica oleracea (Asian species) have been patented as an Antioxidant to protect food (JP2004180578 A, 2002) or plant extracts (from 7 Brassica species) have been patented as an antioxidant for preventive uses or treatment of eye diseases (DE102009058325A1, 2009)
* des extraits du chou rouge chinois a été breveté pour des utilisations médicales anti inflammatoires (KR101424180B1, 2011 ; KR20120130996A, 2011 ; KR20200032579A, 2018) Pour la photoprotection, plusieurs plantes ont été protégés en vue de leur utilisation en écrans solaires (US9056063B2, 2013 ; US 8337820 ; US 821655) * Chinese red cabbage extracts have been patented for anti-inflammatory medical uses (KR101424180B1, 2011; KR20120130996A, 2011; KR20200032579A, 2018) For photoprotection, several plants have been protected for use in sunscreens (US9056063B2, 2013; US 8337820; US 821655)
Le brevet US 8337820 et le brevet US 821655 décrivent tous deux une formulation pour protéger la peau des rayons UV, dans laquelle les ingrédients principaux sont le dioxyde de titane et le 5-hydroxy-tryptophaneet l'extrait de Griffonia simplicifolia. Dans l'art des compositions de protection solaire, on connaît également des compositions contenant des extraits de thé vert, d'Aloe vera, de calendula, de camomille et de romarin. US patent 8337820 and US patent 821655 both describe a formulation to protect the skin from UV rays, in which the main ingredients are titanium dioxide and 5-hydroxy-tryptophan and Griffonia simplicifolia extract. Also known in the art of sun protection compositions are compositions containing extracts of green tea, Aloe vera, calendula, chamomile and rosemary.
Le brevet US 7731942 décrit des produits de protection solaire contenant de la caféine, des extraits d'algues, de l'extrait d'ananas et d'autres ingrédients. Le brevet US 6524599 décrit une composition pour le soin de la peau, des ongles et des cheveux dans laquelle la composition contient du chardon-Marie (Silibum marianum) avec de la protéine de soja et de l'alpha tocophérol. Le brevet US 5876736 décrit une composition de soin de la peau pour revitaliser la peau et comprenant des polysaccharides végétaux parmi divers autres ingrédients. Le brevet US 2011/0229538 décrit une composition totale de soin de la peau (comme crème solaire) contenant une combinaison d'acide ascorbique et d'extraits d'herbes comprennent l'extrait de trèfle rouge, le ginseng et le millepertuis entre autres. US Patent 7731942 describes sunscreen products containing caffeine, seaweed extract, pineapple extract and other ingredients. US patent 6524599 describes a composition for the care of the skin, nails and hair in which the composition contains milk thistle (Silibum marianum) with soy protein and alpha tocopherol. US patent 5876736 describes a skin care composition for revitalizing the skin and comprising plant polysaccharides among various other ingredients. US patent 2011/0229538 describes a total skin care composition (as sunscreen) containing a combination of ascorbic acid and herbal extracts include red clover extract, ginseng and St. John's wort among others.
■ Exposé de l’invention ■ Disclosure of the invention
Dans cette invention, nous décrivons des avantages bénéfiques de l'huile des graines des navets comestibles "Brassica rapa sub rapa" entant que produits de protection de la peau contre les rayons solaires, les irritations chimiques ou autres, le vieillissement, le dessèchement et bloque les effets cancérigènes des rayons solaires par la capacité de l'huile à absorber ces rayonnements ultraviolets. In this invention, we describe the beneficial advantages of the seed oil of the edible turnips "Brassica rapa sub rapa" as products for protecting the skin against sun rays, chemical or other irritations, aging, drying out and blocking the carcinogenic effects of the sun's rays by the ability of the oil to absorb these ultraviolet rays.
Cette huile possède des propriétés absorbantes des rayons UV lui conférant la possibilité d'être utilisée comme filtre des rayons solaires dans toute formulation d'écran solaire seule ou en combinaison avec des filtres physiques. Sa nature huileuse lui permet de s'incoprporer facilement dans toutes les formulations à base de substances à caractère lipidique synthétique (huile de paraffine, vaseline, ..etc) ou naturelle tel le beurre de karité ou autre. This oil has UV absorbing properties giving it the ability to be used as a sunscreen in any sunscreen formulation alone or in combination with physical filters. Its oily nature allows it to be easily incorporated into all formulations based on synthetic lipid substances (paraffin oil, vaseline, etc.) or natural such as shea butter or other.
Cette huile possède également des propriétés antioxydantes importantes. Ceci lui permet de diminuer les réactions des produits ROS issus du métabolisme cellulaire ou des rayons solaires. Son potentiel antioxydant peut diminuer les dommages oxydatifs des rayons solaires et conserver à la peau son élasticité. Ceci est un moyen efficace de lutte contre le vieillissement de la peau. This oil also has significant antioxidant properties. This allows it to reduce the reactions of ROS products from cell metabolism or sunlight. Its antioxidant potential can reduce oxidative damage from sunlight and maintain the skin's elasticity. This is an effective way to fight skin aging.
Cette huile possède une action immunosuppressive et par conséquent anti-inflammatoire ce qui lui permet de lutter contre les irritations normales ou celles induites par les rayons solaires.This oil has an immunosuppressive and therefore anti-inflammatory action which allows it to fight against normal irritations or those induced by the sun's rays.
L’utilisation des écrans solaires permet de protéger la peau contre les effets à court terme et à long terme en particulier, l'oxydation, les brûlures, l'inflammation dus aux UV solaires. Ces écrans solaires sont en majorité fabriqués de plusieurs molécules chimiques qui peuvent induire chez les utilisateurs des réactions indésirables. The use of sunscreens helps protect the skin against the short-term and long-term effects in particular, oxidation, burns, inflammation due to solar UV. These sunscreens are mostly made of several chemical molecules that can induce undesirable reactions in users.
Le but de l'invention est de proposer une composition à usage médical ou cosmétique incluant des lipides des graines de Brassica Rapa subsp rapa qui sont un produit naturel non toxique possédant une protection contre l'oxydation, les brûlures, le dessèchement et l'inflammation de la peau. Ces caractéristiques confèrent à ces lipides l'utilisation comme écran solaire grâce à ses propriétés d’absorption d’ultraviolets, anti -oxydante, et anti-inflammatoire. La propriété huileuse des lipides apporte une hydratation et limite l’évapo-transpiration cutanée, ainsi que dans le traitement des réactions inflammatoires de la peau, irritation, allergie, eczéma, ...etc. pour réduire les réactions inflammatoires. The object of the invention is to provide a composition for medical or cosmetic use including lipids from the seeds of Brassica Rapa subsp rapa which are a non-toxic natural product with protection against oxidation, burns, drying out and inflammation. skin. These characteristics make these lipids useful as a sunscreen thanks to their ultraviolet absorption, anti-oxidant, and anti-inflammatory properties. The oily property of lipids provides hydration and limits cutaneous evapo-transpiration, as well as in the treatment of inflammatory reactions of the skin, irritation, allergy, eczema, etc. to reduce inflammatory reactions.
■ Brève description des figures ■ Brief description of figures
Les figures 1 et 2 relatent les résultats d'absorption des UV montrant que les lipides des graines de Brassica Rapa subsp rapa ont des propriétés d’absorption des rayons en UVA et en UVB. La figure 3 montre l’effet antioxidatif de l'huile des graines de Brassica Rapa subsp rapa comparé au BHT et l'acide Ascorbique Figures 1 and 2 report UV absorption results showing that Brassica Rapa subsp rapa seed lipids have UVA and UVB ray absorption properties. Figure 3 shows the antioxidant effect of Brassica Rapa subsp rapa seed oil compared to BHT and Ascorbic acid
Les figures 4 et 5 montrent l'effet des lipides des graines de Brassica Rapa subsp rapa sur la prolifération des lymphocytes B et T du système immunitaire. Figures 4 and 5 show the effect of Brassica Rapa subsp rapa seed lipids on immune system B and T cell proliferation.
■ Description détaillée de l’invention ■ Detailed description of the invention
L’objet de la présente invention concerne une nouvelle composition à usage médical ou cosmétique comportant des lipides des graines de Brassica Rapa subsp rapa soit seuls soit en combinaison avec d’autre substance. The object of the present invention relates to a new composition for medical or cosmetic use comprising lipids from the seeds of Brassica Rapa subsp rapa either alone or in combination with another substance.
La composition objet de l’invention comporte des pouvoirs d’absorption des ultraviolets A et B qui leurs confèrent la propriété de photoprotection de la peau contre les rayons ultraviolets du soleil. Ces pouvoirs absorbants d’ultraviolet assurent une protection d’environ 90% des rayons en Ultraviolet B et jusqu'à 75% en Ultraviolet A. The composition that is the subject of the invention comprises ultraviolet A and B absorption powers which give them the property of photoprotection of the skin against ultraviolet rays. of the sun. These ultraviolet absorbing powers provide protection of approximately 90% of UV rays in Ultraviolet B and up to 75% in Ultraviolet A.
Selon l’invention, les propriétés huileuses des lipides apportent une hydratation et limite l’évapo-transpiration cutanée. According to the invention, the oily properties of the lipids provide hydration and limit cutaneous evapo-perspiration.
La dite composition comporte des pouvoirs qui lui permet d’avoir plusieurs applications médicales et/ou cosmétique, on en cite les propriétés suivantes : Said composition has powers that allow it to have several medical and / or cosmetic applications, we cite the following properties:
• Pouvoirs antioxydants qui leurs confèrent la propriété d’être utilisés comme substances antivieillissement, anti-âge, antirides. • Antioxidant powers which give them the property of being used as anti-ageing, anti-aging, anti-wrinkle substances.
• pouvoirs d’absorption des ultraviolets A et B qui leurs confèrent la propriété de photoprotection de la peau contre les rayons ultraviolets du soleil • absorption powers of ultraviolet A and B which give them the property of photoprotection of the skin against the ultraviolet rays of the sun
• Pouvoirs anti-irritants qui leurs confèrent la propriété de lutter contre les irritations diverses de la peau tel par les rayons solaires. • Anti-irritant powers which give them the ability to fight against various skin irritations such as the sun's rays.
• Effet immunosuppresseur. • Immunosuppressive effect.
La composition objet de l’invention a également l’avantage de garder toutes les propriétés précitées dans toute base aqueuse ou huileuse liquide ou solide, totale ou partielle. The composition that is the subject of the invention also has the advantage of retaining all the aforementioned properties in any aqueous or oily liquid or solid, total or partial base.
Les figures 1 et 2 relatent les résultats d'absorption des UV montrant que les lipides des graines de Brassica Rapa subsp rapa ont des propriétés d’absorption des rayons en UVA et en UVB. Les absorptions sont plus fortes en UVB qu’en UVA. A 5mg/ml on remarque des absorptions importantes de 1.23 et 1.86 en UVA et UVB respectivement soit plus de 90% du maximal des rayons en UVB. Figures 1 and 2 report UV absorption results showing that Brassica Rapa subsp rapa seed lipids have UVA and UVB ray absorption properties. Absorptions are stronger in UVB than in UVA. At 5mg/ml there are significant absorptions of 1.23 and 1.86 in UVA and UVB respectively, i.e. more than 90% of the maximum of UVB rays.
La figure 3 montre que l’oxydation et les produits libérés au cours de ces réactions au niveau cellulaire peuvent être à l'origine de défaillance cellulaire et de dérèglement des voies métaboliques et enzymatiques. La figure 3 montre que les lipides des graines d t Brassica Rapa subsp rapa possèdent des activités antioxydantes qui peuvent lutter contre l'oxydation provoquée au niveau des cellules de la peau par les rayons solaires Ultraviolets. Cette capacité d'antioxydation de ces lipides augmente en fonction de la concentration. Avec même 0.1 %, on observe un effet antioxydant d'environ 30%. On constate que le maximum est de 83 % pour la concentration 5%. Cet effet antioxydant des lipides des graines de Brassica Rapa subsp rapa est semblable à celui enregistré avec des substances déjà connues pour leur pouvoir antioxydant comme le BHT ou l'acide ascorbique (vitamine C). Les figures 4 et 5 montrent l'effet des lipides des graines de Brassica Rapa subsp rapa sur la prolifération des lymphocytes B et T du système immunitaire. Les résultats obtenus indiquent clairement que l'addition des lipides des graines de Brassica Rapa subsp rapa réduit de plus de 50% la multiplication des lymphocytes B et presque de 30% la multiplication des lymphocytes T. Ceci indique un effet immunosuppresseur et donc anti-inflammatoire puisque l'immunosuppression sur ces lymphocytes va bloquer la synthèse de cytokines et de médiateurs d'inflammation généralement secrétés par ces cellules. Cet effet -des lipides des graines de Brassica Rapa subsp rapa de réduction des médiateurs de l'inflammation va réduire les effets inflammatoires des rayons solaires sur la peau en diminuant les réactions immunitaires au niveau de la zone qui reçoit les rayons solaires. Figure 3 shows that oxidation and the products released during these reactions at the cellular level can be the cause of cell failure and disruption of metabolic and enzymatic pathways. Figure 3 shows that the lipids of the dt Brassica Rapa subsp rapa seeds possess antioxidant activities which can fight against the oxidation caused at the level of the cells of the skin by the solar Ultraviolet rays. This antioxidant capacity of these lipids increases according to the concentration. With even 0.1%, an antioxidant effect of about 30% is observed. It can be seen that the maximum is 83% for the 5% concentration. This antioxidant effect of Brassica Rapa subsp rapa seed lipids is similar to that recorded with substances already known for their antioxidant power such as BHT or ascorbic acid (vitamin C). Figures 4 and 5 show the effect of Brassica Rapa subsp rapa seed lipids on immune system B and T cell proliferation. The results obtained clearly indicate that the addition of lipids from the seeds of Brassica Rapa subsp rapa reduces the multiplication of B lymphocytes by more than 50% and the multiplication of T lymphocytes by almost 30%. This indicates an immunosuppressive and therefore anti-inflammatory effect. since immunosuppression on these lymphocytes will block the synthesis of cytokines and inflammation mediators generally secreted by these cells. This effect of Brassica Rapa subsp rapa seed lipids in reducing inflammation mediators will reduce the inflammatory effects of the sun's rays on the skin by reducing the immune reactions in the area that receives the sun's rays.
Les lipides des graines de Brassica Rapa subsp rapa comme écran solaireLipids from Brassica Rapa subsp rapa seeds as sunscreen
Les caractéristiques d'un écran solaire est toute composition capable de réduire les effets des rayons solaires : les UV, l'inflammation et l'oxydation tissulaire. The characteristics of a sunscreen is any composition capable of reducing the effects of solar rays: UV rays, inflammation and tissue oxidation.
D'après les résultats obtenus, les lipides des graines de Brassica Rapa subsp rapa possèdent ces trois propriétés, ces lipides sont antioxydants, photo-absorbants des UV et anti-inflammatoires. Ceci justifie aux lipides des graines de Brassica Rapa subsp rapa leur utilisation comme écran solaire pour se protéger contre les effets néfastes des rayons solaires. According to the results obtained, the lipids of the seeds of Brassica Rapa subsp rapa have these three properties, these lipids are antioxidants, UV photo-absorbents and anti-inflammatory. This justifies the lipids of the seeds of Brassica Rapa subsp rapa their use as a sunscreen to protect against the harmful effects of the sun's rays.
Les lipides des graines de Brassica Rapa subsp rapa en Médical Lipids of Brassica Rapa subsp rapa seeds in Medical
Les propriétés anti-inflammatoire des lipides des graines de Brassica Rapa subsp rapa leur permettent d'être utilisés dans le traitement des réactions inflammatoires de la peau, irritation, allergie, eczéma, ...etc. pour réduire les réactions inflammatoires. The anti-inflammatory properties of the lipids of the seeds of Brassica Rapa subsp rapa allow them to be used in the treatment of inflammatory reactions of the skin, irritation, allergy, eczema, etc. to reduce inflammatory reactions.
Ces lipides non toxiques peuvent être utilisés dans la lutte contre le dessèchement de la peau par leurs caractères émollients. These non-toxic lipids can be used in the fight against skin dryness through their emollient properties.
■ Application industrielle : ■ Industrial application:
Selon l’invention, la composition peut être appliqué dans le domaine cosmétique et/ou médical comme écran solaire pour se protéger contre les effets néfastes des rayons solaires ainsi que le traitement des réactions inflammatoires de la peau, irritation, allergie, eczéma, ...etc. pour réduire les réactions inflammatoires. According to the invention, the composition can be applied in the cosmetic and/or medical field as a sunscreen to protect against the harmful effects of the sun's rays as well as the treatment of inflammatory reactions of the skin, irritation, allergy, eczema, etc. .etc. to reduce inflammatory reactions.

Claims

Revendications Claims
1. Composition à usage médical ou cosmétique caractérisée en ce qu’elle comporte des lipides des graines de Brassica Rapa subsp rapa seuls ou en combinaison avec d’autres substances. 1. Composition for medical or cosmetic use characterized in that it contains lipids from the seeds of Brassica Rapa subsp rapa alone or in combination with other substances.
2. Composition à usage médical ou cosmétique, selon la revendication 1, caractérisée en ce qu’elle possède des pouvoirs d’absorption des ultraviolets A et B qui leurs confèrent la propriété de photoprotection de la peau contre les rayons ultraviolets du soleil.2. Composition for medical or cosmetic use, according to claim 1, characterized in that it has ultraviolet A and B absorption powers which give them the property of photoprotection of the skin against the ultraviolet rays of the sun.
3. Composition à usage médical ou cosmétique, selon les revendications 1 et 2, caractérisée en ce que ses pouvoirs absorbants d’ultraviolet assurent une protection d’environ 90% des rayons en Ultraviolet B et jusqu'à 75% en Ultraviolet A. 3. Composition for medical or cosmetic use, according to claims 1 and 2, characterized in that its ultraviolet absorbing powers ensure protection of approximately 90% of the rays in Ultraviolet B and up to 75% in Ultraviolet A.
4. Composition à usage médical ou cosmétique, selon l’une des revendications précédentes, caractérisée en ce que les propriétés huileuses des lipides apportent une hydratation et limite l’évapo-transpiration cutanée. 4. Composition for medical or cosmetic use, according to one of the preceding claims, characterized in that the oily properties of the lipids provide hydration and limit cutaneous evapo-perspiration.
5. Composition à usage médical ou cosmétique, selon la revendication 1, caractérisée en ce qu’elle comporte des pouvoirs antioxydants qui leurs confèrent la propriété d’être utilisés comme substances antivieillissement, anti-âge, antirides. 5. Composition for medical or cosmetic use, according to claim 1, characterized in that it comprises antioxidant powers which give them the property of being used as anti-ageing, anti-aging, anti-wrinkle substances.
6. Composition à usage médical ou cosmétique, selon la revendication 1, caractérisée en ce qu’elle comporte des pouvoirs anti -irritants qui leurs confèrent la propriété de lutte contre les irritations diverses de la peau tel par les rayons solaires. 6. Composition for medical or cosmetic use, according to claim 1, characterized in that it comprises anti-irritant powers which give them the property of fighting against various irritations of the skin such as by the sun's rays.
7. Composition à usage médical ou cosmétique, selon la revendication 1, caractérisée en ce qu’elle possède un effet immunosuppresseur. 7. Composition for medical or cosmetic use, according to claim 1, characterized in that it has an immunosuppressive effect.
8. Composition à usage médical ou cosmétique, selon l’une des revendications précédentes, caractérisée en ce qu’elle garde toutes ses propriétés précitées dans toute base aqueuse ou huileuse liquide ou solide, totale ou partielle. 8. Composition for medical or cosmetic use, according to one of the preceding claims, characterized in that it retains all of its aforementioned properties in any liquid or solid aqueous or oily base, total or partial.
9. Composition à usage médical ou cosmétique, selon l’une des revendications précédentes, caractérisée en ce qu’elle peut être appliquée comme écran solaire pour se protéger contre les effets néfastes des rayons solaires, pour le traitement des réactions inflammatoires de la peau, irritation, allergie, eczéma, ...etc. 9. Composition for medical or cosmetic use, according to one of the preceding claims, characterized in that it can be applied as a sunscreen to protect against the harmful effects of the sun's rays, for the treatment of inflammatory reactions of the skin, irritation, allergy, eczema, etc.
PCT/MA2022/050003 2021-03-23 2022-03-22 Composition for medical or cosmetic use containing lipids from seeds of brassica rapa subsp rapa WO2022211610A2 (en)

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