JP2006151901A - Sprayable oil-in-water emulsion - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a sprayable sunscreen preparation having high SPF (sun protection factor) value. <P>SOLUTION: The sprayable oil-in-water emulsion comprises a high concentration oil phase. Wherein the sprayable oil-in-water emulsion contains at least 15% oil phase and the preparation of the emulsion contains at least 0.1% alkyl glycol. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The invention relates to a sprayable oil-in-water emulsion having a high content of oil phase.

  Spray is attractive as a means of transport for applying liquid formulations to the skin, such as skin care and cosmetic applications. Spraying is easy to use and typically allows even more controlled application of the formulation to the skin. Formulations used on the skin often take the form of emulsion systems, usually oil-in-water (O / W) emulsions, which recognize the presence of lipophilic and hydrophilic components in certain formulations. . In many cases, emulsion-based formulations require a relatively high content of lipophilic ingredients. This is, for example, necessary in formulations to have a high content of lipophilic active ingredients, and then with these active ingredients the relatively high required to make up a liquid oil phase. This is the case when the presence of a liquid oily component in the content is essential. However, emulsions with a high content of oil phase require a relatively high content of emulsifier. This, in turn, results in an increase in viscosity resulting in the inability to spray the formulation.

  Sunscreen formulations are also frequently formulated as oil-in-water emulsions. Sunscreen formulations with high SPF (also referred to as sunscreen index) are currently increasingly desired by consumers because of the increased awareness of skin disorders and the effects of prolonged skin exposure to sunlight. Sunscreen formulations with a sunscreen index of SPF ≧ 50 are recommended for sensitive skin types and for children. In such a sunscreen preparation having a high SPF value, the presence of a high content UV filter agent is indispensable. Of the lipophilic filter agents that are most effective and therefore widely used in sunscreen formulations, UV filter agents are the most frequently selected. Options for lipophilic UV filter agents are limited, and increasing the content of this type of filter agent is insufficient to reach high SPF values, and usually induces a state of white coloration during application. This is because it makes a good impression. Inorganic pigments are other types of filter agents and their content can be increased, but this increase in content leads to problems with the stability and white coloration of the formulation. Therefore, sunscreen formulations with high SPF values can only be obtained by adding higher amounts of lipophilic filter agents. This is a special approach to sprayable formulations, as increasing the content of lipophilic components in the sprayable formulation requires more emulsifiers and results in increased viscosity. Is to raise.

  Patent Document 1 relates to a light-resistant cosmetic emulsion or skin emulsion, which emulsion comprises (a) at least one benzotriazole derivative and (b) at least 1 having an average particle size from 100 nm to 400 nm. Contains two grades of latex particles.

  Patent Document 2 relates to a composition containing caprylyl glycol or a homologue thereof and a preservative. Further, Patent Document 2 relates to improving the activity of a preservative using caprylyl glycol or a homologue thereof. Patent Document 3 additionally relates to a specific combination of a chemical composition containing a caprylyl glycol or a homologue thereof and a preservative. Furthermore, Patent Document 3 relates to a combination of iodopropynylbutyl carbamate and phenoxyethanol, using caprylyl glycol or a homologue thereof to improve the activity of a preservative.

  Patent Document 4 discloses a cosmetic composition or an outer skin composition containing an alkynyl carbamate derivative and a polyhydric alcohol, which is useful for treating Malassezia infections, particularly dandruff.

There is therefore a need to provide sprayable formulations with a high content of lipophilic components. In particular, there is a need for sprayable formulations containing a relatively high content of lipophilic ingredients, in particular lipophilic active ingredients. There is a more specific need to provide sprayable sunscreen formulations with high SPF values. It is an object of this invention to provide such a formulation.
International Publication No. WO 03/013455 European Patent Application No. 206,933 European Patent Application Publication No. 238,651 European Patent Application Publication No. 005,851 European Patent Application Publication No. 761,201 US Pat. No. 5,663,213 Wenninger and McEwen (CTFA, 7th edition, 1997), pages 1654 to 1655

  The object of the present invention is to provide a sprayable sunscreen formulation having a high SPF value.

  The invention according to claim 1 of the present invention is a sprayable oil-in-water emulsion comprising at least 15% oil phase and the preparation contains at least 0.1% alkyl glycol.

  According to this invention, there exists an effect that the sprayable sunscreen formulation which has a high SPF value can be provided.

Summary of the Invention

  Thus, in one embodiment, this invention relates to a sprayable oil-in-water emulsion comprising at least 15% oil phase, the formulation containing at least 0.1% alkyl glycol. ing.

  In another embodiment, the invention relates to a sprayable oil-in-water emulsion comprising at least 15% lipophilic active ingredient, the emulsion comprising at least 15% oil phase, the formulation comprising Contains at least 0.1% alkyl glycol.

  In another embodiment, the invention relates to a sprayable oil-in-water emulsion that is a sunscreen formulation comprising at least 5% lipophilic UV filter agent, the emulsion comprising at least 15% oil phase. And the formulation contains at least 0.3% alkyl glycol. The sunscreen formulations of this invention may have a high SPF value, for example SPF ≧ 40, more preferably SPF ≧ 50, even more preferably SPF ≧ 60.

  Particular embodiments of this invention contain active ingredients or other active ingredients that can be UV filter agents, and contain at least 20%, or even at least 25%, or even at least 30% oil phase. It is an emulsion including all emulsions.

  Another specific embodiment of the invention contains an active ingredient or other active ingredient that can be an ultraviolet filter agent, and contains at least 0.3% alkyl glycol, and at least 0.3% alkyl glycol. It is an emulsion including all the emulsions it contains.

  In another embodiment, the invention relates to a sprayable oil-in-water emulsion, the emulsion containing from 15% to 40%, in particular from 20% to 30% oil phase, It contains from 1% to 10%, in particular from 0.2% to 5%, further from 0.3% to 3% alkyl glycol, preferably caprylyl glycol.

  In another embodiment, the invention relates to a sprayable oil-in-water emulsion, wherein the emulsion contains from 15% to 40%, in particular from 20% to 30% oil phase; (A) a lipophilic active ingredient contained in the oil phase in an amount of 5% to 30%, in particular 10% to 30%, further 10% to 30%, and further 10% to 20%; (B) from 0.1% to 10%, in particular from 0.2% to 5%, further from 0.3% to 3% of alkyl glycols, preferably capric when the alkyl glycol is at least 0.3%. Contains ril glycol.

  In another embodiment, the invention relates to a sprayable oil-in-water emulsion that is a sunscreen formulation, the emulsion containing from 15% to 40%, in particular from 20% to 30% oil phase. (A) contained in the oil phase in an amount of 5% to 30%, in particular 10% to 30%, further 10% to 30%, and further 10% to 20%. A lipophilic UV filter agent and (b) 0.1% to 10%, in particular 0.2% to 5%, further 0.3% to 3% alkyl glycol, preferably caprylyl glycol. .

  A suitable alkyl glycol is caprylyl glycol, also called 1,2-octanediol.

  As used in this specification and claims, all percentages are percentages by weight, unless otherwise indicated. The symbol “≧” means greater than or equal to.

The term “sprayable” means that the composition can be applied by standard spray equipment used in consumer products. In particular, sprayable emulsions are measured from 100 centipoise to 2000 centipoise, especially from 100 centipoise to 1000 centipoise, measured at a constant shear rate of 60 s ^-1 using a spindle rotation rheometer equipped with a spindle that provides a suitable viscosity range. Viscosity up to.

The alkyl glycols particularly used in the emulsions of this invention are C _6-14 alkyl glycols, further C _8-12 alkyl glycols, also C ₈ alkyl glycols, and also caprylyl glycol, also called 1,2-octanediol. It is. Examples of alkyl glycols are 2,3-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-heptanediol, 1,2-hexanediol, 3,4-octanediol and these Including the same. Of these, specific targets are alkyl glycols in which one hydroxyl group is substituted at the carbon terminus and another hydroxyl group is substituted on another carbon atom close to the substituent.

  The term “oil phase” includes the sum of all lipophilic components. These lipophilic components may contain oils, lipids, waxes, lipophilic active ingredients, lipophilic polymers and the like.

Oil phase The oil-in-water emulsion of the present invention is not mixed with skin-compatible components such as silicone oil, natural oil, fatty acid ester, mono-, di- or tri-type glycerides, or mixtures thereof, or water thereof. It contains an oil phase that may include suitable oils that are mixtures. In addition, oils are liquid at ambient temperature, especially at 25 ° C. These oils can contain a certain amount of oily solid components (eg lipids or waxes) as long as the complete oily mixture is liquid at ambient temperature or at the temperatures described above.

  Oils that can be incorporated into the oil phase include, in particular, plant-derived natural oils or natural oil derivatives. Examples are almond oil, soybean oil, sunflower oil, safflower oil, corn oil, canola oil, borage oil, evening primrose oil, grape seed oil, malt oil, avocado oil, jojoba oil, kernel oil, sesame oil, walnut oil, flax seed Oil, palm oil, olive oil, macadamia oil, castor oil, rapeseed oil, peanut oil, palm oil and turnip seed oil.

The oil phase in the emulsion may contain mono-, di-, or tri-type glycerides or a mixture thereof. These components can be natural oils as described above, but oily components separated from natural oils, such as triglycerides or mixtures of triglycerides separated from natural oils, or chemically produced mono-, di-, or Tri-type glycerides may be contained. Mono-, di- or tri-type glycerides can be derived from saturated or unsaturated, linear or branched, substituted or unsubstituted fatty acids or fatty acid mixtures. In particular, such glycerides include mono-, di-, or tri-type C _6-30 fatty acid glycerides, and also mono-, di-, or tri-type C _8-24 fatty acid glycerides, especially mono-, di-, or tri-type C glycerides. _{Contains 12-22} fatty acid glycerides. Also included are mixtures of glyceride esters, ie diglyceride esters or triglyceride esters having two or three different fatty acids. Mixtures of mono-, di-, or tri-type glycerides include industrial mixtures derived from the fraction of fatty acids obtained by hydrolysis from a fraction of oils or lipids. An example of the latter is an industrial mixture of C _12-18 fatty acids and mono-, di- or tri-type glycerides.

  Examples of glyceride oils are mono-, di-, or tri-forms derived from palmitic acid, palmic, oleic acid, lauric acid, myristic acid, stearic acid, hydroxystearic acid, behenic acid, or mixtures thereof. Glycerides.

  Of these, particular subjects are triglycerides, including triglyceride mixtures, and also include mixed esters, ie, triesters of different fatty acids and glycerin. Examples are glyceryl tristearate, glyceryl trioleate, glyceryl tripalmitate, glyceryl trimyristate, glyceryl tribehenate, glyceryl trilaurate.

The subject monoglycerides or diglycerides are mono- or di-type C _12-24 fatty acid glycerides, especially mono- or di-type C _16-20 fatty acid glycerides such as glyceryl monostearate, glyceryl distearate, glyceryl laurate, Glyceryl dilaurate, glyceryl palmitate, and glyceryl dipalmate.

The oil phase in the emulsion may also contain fatty acid alkyl esters. Here, the latter alkyl group may be linear or branched, saturated or unsaturated, substituted or unsubstituted, 1 to 30 carbon atoms, especially 1 to 22 Of carbon atoms. Fatty acids in the above alkyl esters are linear or branched, saturated or unsaturated, substituted or unsubstituted C _6-30 fatty acids or fatty acid mixtures, in particular C _6-24 fatty acids, and further C _8-22 fatty acids, Furthermore, _C12-18 fatty acid may be sufficient. The alkyl groups in the esters are preferably derived from aliphatic alcohols and mixtures thereof, in particular C _1-24 aliphatic alcohols, further C _6-22 aliphatic alcohols, further C _8-18 aliphatic alcohols. The fatty alcohol mixtures used in these esters can be obtained, for example, by high-pressure hydrolysis of industrial mixtures of methyl esters derived from lipids or oils.

  Examples of the ester type oily component include decyl oleate, coco caprylic acid / capric acid, hexyl laurate, myristyl isostearate, myristyl oleate, cetyl isostearate, cetyl oleate, cetyl stearate, Cetyl behenate, cetyl palmitate, cetearyl behenate, isostearyl myristate, isostearyl palmitate, isostearyl stearate, isostearyl isostearate, isostearyl oleate, isostearyl behenate, oleyl myristate, oleyl isostearate, Oleate oleate, oleyl erucate, oleyl palmitate, oleyl stearate, oleyl isostearate, oleyl oleate, oleyl behenate, isoleate , Erucyl oleate, palmityl stearate, stearyl heptanoate, stearyl octanoate, stearyl stearate, stearyl isostearate, stearyl behenate, stearyl oleate, myristyl myristate, myristyl palmate, myristyl stearate, myristyl isostearate, They are myristyl oleate, behenyl behenate, behenyl isostearate and behenyl oleate.

The subject of the oil components of the ester type, branched C _1-12 alkanols, linear with a particular 2-ethylhexanol (e.g. trade name Cetiol (Cetiol)) the latter stearate which is commercially available in 868) C ₆ Esters derived from _-22 fatty acids; esters derived from branched C _6-22 fatty acids having linear C _1-12 alkanols; C _12-30 hydroxy fatty acids having linear or branched C _6-22 fatty acids Esters derived from: linear or branched fatty acid-derived esters having polyfunctional alcohols (eg propylene glycol, dimer diol or trimer triol) or Guerbet alcohols; aromatic carboxylic acids Esters derived from C _6-22 aliphatic alcohols or Gerve alcohols, particularly with benzoic acid; having 1 to 22 carbon atoms Esters derived from C _2-12 dicarboxylic acids having linear or branched alcohols (for example, dioctyl maleate); polyalcohols (for example, propylene glycol, dimer diol or trimer triol) or Gerve alcohols These esters are composed of linear or branched fatty acids having As used in this specification, Gerve alcohols may be aliphatic alcohol systems having from 6 to 18, especially 8 to 10 carbon atoms.

Other oily components that can be used are those containing fatty alcohols, in particular all saturated or unsaturated, linear or branched fatty alcohols and mixtures thereof. Aliphatic alcohols include, for example, myristyl alcohol, 1-pentadecanol, cetyl alcohol, 1-heptadecanol, stearyl alcohol, 1-nonadecanol, arachidyl alcohol, 1-heneicosanol, behenyl alcohol, brassyl alcohol, ligno. Seryl alcohol, ceryl alcohol, mytilyl alcohol, lauryl alcohol, capryl alcohol, caprinyl alcohol, cetyl alcohol, palm oleyl alcohol, isostearyl alcohol, oleyl alcohol, elaidyl alcohol, petrocerinyl alcohol, arachidyl alcohol, gadorail alcohol , erucyl alcohol, and cetearyl alcohol, top of the mixture such as C _12/13 fatty alcohols and Guerbet alcohols Lipids of, oils or waxes for example C _12-50 aliphatic derived from such alcohols, in particular C _12-24 fatty alcohols, and further comprising a C _16-22 fatty alcohols.

  Mixtures of fatty alcohols can obviously be used, and this mixture is a response obtained by reduction of a fatty acid fraction derived from naturally occurring oils or lipids such as the natural oils or lipids mentioned above. Of the aliphatic alcohol fraction.

Other oily components include fatty acids, particularly C _14-40 fatty acids, and hydroxy aliphatic alcohols, particularly C _12-30 fatty alcohols. Other oily components that can be used are those that include either aliphatic or aromatic mineral oils, paraffinic oils and synthetic oils, and mixtures thereof.

  Other oily components that can be added are gerber alcohols which can be based on aliphatic alcohols having from 6 to 18, in particular from 8 to 10, carbon atoms.

  Still other oily components are hydrocarbons, which include, for example, squalane, squalene, paraffin oils, isohexadecane, isoeicosane or polydecene and dialkylcyclohexanes.

  Still other oily components include, for example, cyclic silicones, dialkylaryl siloxanes or alkylaryl siloxanes such as cyclomethicone, dimethylpolysiloxane and methylphenylpolysiloxane, and alkoxylated and quaternized homologues thereof. Silicone oils. Suitable non-volatile silicone oils are, for example, polyalkyl siloxanes, polyalkylaryl siloxanes and polyether siloxane copolymers. Particularly suitable silicone oils include dimethylpolysiloxane having trimethylsiloxy groups at both molecular ends, methylphenylpolysiloxane having trimethylsiloxy groups at both molecular ends, methylphenylsiloxane and dimethylsiloxane having trimethylsiloxy groups at both molecular ends, and The copolymer may be cyclic dimethylsiloxane or cyclic methylphenylsiloxane.

  Suitable silicone oils are those containing cyclic dimethyl silicones, i.e. cyclomethicones such as tetracyclomethicone, pentacyclomethicone and linear dimethyl silicones, i.e. dimethicones, and all mixtures thereof.

  The oil phase can also contain a certain amount of solid or semi-solid lipophilic components such as lipids and waxes, and these components are liquid at or above ambient temperature, in particular at or above 25 ° C. Material. Lipids include substances derived from natural products or synthetic substances such as triglycerides. Waxes include synthetic or natural waxes. Natural waxes include wood wax, aurikuri wax, montan wax, castor wax, carnauba wax, candelilla wax, beeswax, ceresin wax and odor wax. Synthetic waxes include petroleum waxes such as paraffin, petrolatum, polyalkylene glycol waxes such as polyethylene wax.

  Waxes are higher homologues of the above-mentioned materials such as oils, for example higher esters, higher mono-, di- or tri-type glycerides, higher alkanols (especially higher aliphatic alcohols), higher alkanediols. (Particularly hydroxy aliphatic alcohols) and materials which are higher fatty acids are also included. As other useful ingredients, silicone waxes can be described.

Aqueous Phase The aqueous phase in the oil-in-water emulsion of the present invention may be pure water, but may usually contain one or more hydrophilic components. The latter hydrophilic components can be lower alkanols, polyhydric alcohols, water-soluble active ingredients, preservatives and humectants, chelating agents, and the like.

Emulsifier The oil-in-water emulsion of the present invention additionally contains one or more emulsifiers suitable for forming an oil-in-water emulsion. These emulsifiers may be anionic, cationic, amphoteric or nonionic emulsifiers and mixtures thereof. Nonionic emulsifiers are preferred.

  Suitable anionic emulsifiers include fatty acid soaps, such as sodium, potassium and triethanolamine soaps, where the fatty acid portion may contain from 10 to 20 carbon atoms. Other suitable cationic emulsifiers are alkyl sulfonates, alkyl sulfates, alkyl aryl sulfonates, alkyl polyethoxy ether sulfonates, alkyl phenol polyethoxy ether sulfonates, mono- or diesters of sulfosuccinic acid. In particular, these alkali metal salts, ammonium salts or substituted ammonium salts are included. The alkyl group may be from 10 to 30 carbon atoms and the polyethoxylated anionic emulsifier may contain from 1 to 50, in particular from 2 to 25 ethylene oxide units.

  Suitable cationic emulsifiers are quaternary ammonium salts, morpholinium salts and pyridinium salts, especially tetraalkylammonium halides such as alkyltrimethylammonium halides in which the alkyl group can be from 10 to 30 carbon atoms. It is.

Certain nonionic emulsifiers are:
(1) 2 to 50 moles of ethylene oxide and / or 0 to 20 moles of propylene oxide, linear aliphatic alcohols having 8 to 40 carbon atoms, 12 to 40 Addition products added to fatty acids having 5 to 15 carbon atoms and alkylphenols having 8 to 15 carbon atoms in the remaining alkyl groups;
(2) C _12/18 fatty acid monoesters and diesters of addition products of 1 to 50 moles of ethylene oxide and glycerol;
(3) Glycerin monoesters and diesters, sorbitan monoesters and diesters of saturated and unsaturated fatty acids having 6 to 22 carbon atoms and the ethylene oxide addition product;
(4) alkyl monoglycosides and alkyl oligoglycosides having 8 to 22 carbon atoms in the remaining alkyl groups and their ethoxylated analogues (5) from 7 to 60 moles of ethylene oxide, castor oil and An addition product added to the hardened castor oil;
(6) Polyhydric alcohols, especially polyglycerin esters, such as polyhydric alcohol / poly 12-hydroxystearate, polyglycerin / polyricinoleate, polyglycerin / diisostearate or polyglycerin / dimerate. Also suitable are mixtures of several compounds of the above substances.
(7) Addition products in which from 2 moles to 15 moles of ethylene oxide are added to the castor oil and / or hardened castor oil;
(8) Linear, branched, unsaturated or saturated C _6-22 fatty acids, ricinoleic acid and 12-hydroxystearic acid, glycerin, polyglycerin, pentaerythritol, dipentaerythritol, sugar alcohols ( Eg, sorbitol), alkyl glucosides (eg methyl glucoside, butyl glucoside, lauryl glucoside), and polyglucosides (eg cellulose) or partial esters derived from ester mixtures such as stearic acid / glyceryl citrate and stearic acid / glyceryl lactate Kind;
(9) Wool fat alcohols;
(10) Polysiloxanes, polyalkyls, polyethers, copolymers and derivatives thereof;
(11) pentaerythritol, ester mixtures derived from fatty acids and fatty alcohols and / or ester mixtures of fatty acids having 6 to 22 carbon atoms and having methyl glucose and polyhydric alcohols, respectively glycerin or Polyglycerin;
(12) Polyalkylene glycols containing a block copolymer of ethylene oxide and propylene oxide are included.

  Ethylene oxide and / or propylene oxide, aliphatic alcohols, fatty acids, alkylphenols, glycerin fatty acid / monoester, glycerin fatty acid / diester, sorbitan fatty acid / monoester, sorbitan fatty acid / diester, or glycerin castor oil / monoester, glycerin Custer oil / diester and addition products of sorbitan caster oil / monoester and sorbitan caster oil / diester are known and commercialized. Usually, when the addition reaction is carried out, there is a mixture of homologues such that the average degree of alkoxylation corresponds to the ratio of the starting amount of ethylene oxide and / or propylene oxide to the substrate.

  Examples of suitable zwitterionic emulsifiers are those containing alkyl dimethylamine oxide in which the alkyl group has from 6 to 16 carbon atoms.

  The emulsion may contain from about 1% to about 10%, preferably from about 2% to about 5% of an emulsifier.

Active ingredient The emulsions of this invention may contain an active ingredient for skin application. Examples of active ingredients are antimicrobial agents such as antibacterial agents, antifungal agents, anti-inflammatory agents, anti-irritant compounds, anti-itch agents, moisturizers, skin care ingredients, plant extracts, vitamins and similar Including things. Examples of such components are PVP (polyvinylpyrrolidone) and hydrogen peroxide complexes, plant extracts, bisabolol, panthenol, tocopherol and other anti-inflammatory agents, anti-stinging agents, anti-irritants, anti-dandruff agents , Containing an anti-aging agent such as retinol, melibiose and the like. Other suitable active ingredients are, for example, allantoin, aloe barbadensis, macarus wheat, β-carotene, bisabolol, pharmacopoeia Borago, recutita, dichlorophenylimidazole dioxalane, ethyl panthenol, Farnesol, ferulic acid, ginkgo, heliotropin, wheat protein hydrolysate, pepper, milk protein, lactose, linalool, lysine, mannitol, mint, menthol, menthyl lactate, olaflur, rice, panthenol, almond darcis (Dulcis), retinyl palmitate, castor bean, mannen wax, salicylic acid, sodium carboxymethyl β-glucan, sodium cocoyl amino acid, sodium hyaluronate, sodium palmitoylproline, Jakousou, tocopherol, tocopheryl acetate, tyrosine, valine or the like.

  The active ingredient can be present in various concentrations depending on the nature and use of the ingredient, but is usually from 0.01% to 10% (w / w) based on the total weight of the emulsion. It is present in an amount ranging from 0.1% to 7% (w / w) and more preferably from 1% to 5% (w / w).

The emulsion according to the present invention can be used as an antiperspirant or deodorant, and one or both phases of the emulsion contain an active ingredient having deodorant and / or antiperspirant properties. Active ingredients which can be used for this purpose are, for example, aluminum / chlorohydrates, aluminum / zirconium / chlorohydrates and antiperspirants such as zinc salts. Such other agents include aluminum hydroxylactates as well as aluminum acid / zirconium salts. Particularly suitable chlorohydrates are compounds of the formula [Al ₂ (OH) ₅ Cl] -2,5H ₂ O. In addition, such agents are aluminum-zirconium-tetrachlorohydroxy complexes. Esterase inhibitors can be added as other deodorants, ie as agents such as trialkyl citrate such as trimethyl citrate, tripropyl citrate, triisopropyl citrate, tributyl citrate and especially triethyl citrate . Other esterase inhibitors include, for example, lanosterine sulfate, cholesterol ester, campesterin sulfate, steroster sulfate such as stigmasterin sulfate and sitosterin sulfate, lanosterine phosphate, cholesterol esterase, campesterin phosphate, stigmasterine phosphate and sitosterine phosphate, etc. Dicarboxylic acids such as glutaric acid, glutaric acid monoethyl ester, glutaric acid diethyl ester, adipic acid, adipic acid monoethyl ester, adipic acid diethyl ester, malonic acid, malonic acid diethyl ester, and esters thereof, For example, hydroxycarbonic acid such as citric acid, malonic acid, tartaric acid or diethyl tartrate and esters thereof.

  Antibacterial active ingredients that affect bacterial growth conditions and eradicate or impede bacteria that perspire to rot can also be present in the oil and / or water phase. . Examples of such components are phenoxyethanol, chlorohexidine gluconate and 5-chloro-2- (2,4-dichlorophenoxy) -phenol.

  The emulsions according to the invention can be used in sunscreen applications when in the form of sunscreen sprays. In these products, the oil phase and / or aqueous phase is one or more organic substances that are capable of absorbing, for example, ultraviolet radiation and are free of absorbed energy, such as long-wavelength radiation. Contains sunscreen filter agent.

UVB (medium wavelength ultraviolet) filter agents can be oil-soluble or water-soluble. Examples of oil-soluble substances include:
3-benzylidene camphor; 3-benzylidene norcamphor and its derivatives, such as 3- (4-methylbenzylidene) camphor, 4-aminobenzoic acid derivatives; 4- (dimethylamino) benzoic acid-2-ethylhexyl esters, 4- (Dimethylamino) benzoic acid-2-octyl ester and 4- (dimethylamino) benzoic acid amyl ester / cinnamonic acid ester; in particular 4-methoxycinnamonic acid-2-ethylhexyl ester, 4-methoxycinnamonic acid propyl Ester, 4-methoxycinnamonic acid isoamyl ester, 2-cyano-3,3-phenylcinnamonic acid-2-ethylhexyl ester (octocrylene)
Salicylic acid esters; salicylic acid-2-ethylhexyl ester, salicylic acid-4-isopropylbenzyl ester, salicylic acid homomenthyl ester, benzophenone derivatives; especially 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'- Methylbenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone-benzalmalonic acid esters; in particular 4-methoxybenzmalonic acid di-2-ethylhexyl ester-triazine derivatives; for example 2,4,6-trianilino- (p- Carbo-2′-ethyl-1′-hexyloxy) -1,3,5-triazine and octyl triazone trypan-1,3-diones; for example 1- (4-tert-butylphenyl) -3- (4 '-Methoxyphenyl) propane-1 3-dione keto trichloro (5,2,1,0) decane derivatives can be described.

Examples of water-soluble UV filter agents include:
2-phenylbenzimidazole-5-sulfonic acid and its alkali, alkaline earth, ammonium, alkylammonium, alkanolammonium and glucammonium salts, benzophenonesulfonic acid derivatives; in particular 2-hydroxy-4- Methoxybenzophenone-5-sulfonic acid and its salts, 3-benzylidene camphorsulfonic acid derivatives; for example, 4- (2-oxo-3-bornylidenemethyl) benzolsulfonic acid and 2-methyl-5- (2-oxo -3-bornylidene) sulfonic acid and its salts.

  Typical UVA (long wavelength ultraviolet) filter agents that can be used are, for example, 1- (4′-tert-butylphenyl) -3- (4′-methoxyphenyl) propane-1,3-dione, 4-tert. These are benzoylmethane derivatives such as 3-butyl-4′-methoxybenzoylmethane (Parsol (trade name)) or 1-phenyl-3- (4′-isopropylphenyl) propane-1,3-dione. A mixture of UVA (long wavelength ultraviolet) filter agent and UVB (medium wavelength ultraviolet) filter agent can obviously also be used.

  A particular object is a so-called wide frequency band filter agent. One type of such filter agent is a water-soluble filter agent, and also benzotriazoles, particularly 2,2′-methylene-bis (6- (2H-benzotriazol-2-yl) -4- (1,1,1). 3,3-tetramethylbutyl) -phenol) [INCI: bisoctyltriazole], which is a benzotriazole derivative marketed under the trade name Tinosorb M from CIBA Chemicals. Another useful benzotriazole derivative is 2- (2H-benzotriazol-2-yl) -4-methyl-6- [2-methyl-3- [, which is also indicated by the INCI name, drometrizol trisiloxane. 1,3,3,3-tetramethyl-1 [(trimethylsilyl) oxy] disiloxanyl] propyl] -phenol (case number: 155633-54-8), available under the trade name Mexoryl XL from Kimex It is. These benzotriazole derivatives can be easily incorporated into the aqueous phase at pH> 4.5.

  Another useful water-soluble UV filter agent is indicated by the INCI name: terephthalidine dicamphor sulfonic acid (case number: 90457-82-2) and is available, for example, from Kimex Corporation under the trade name Mexoryl SX. 3,3 ′-(1,4-phenylenedimethylene) bis (7,7-dimethyl-2-oxo-bicyclo- [2.2.1] hept-1-yl) methanesulfonic acid and its sodium salt, potassium Salts, or triethanolammonium salts thereof, and sulfonic acids thereof are sulfonated UV filter agents.

  Oil-soluble wide frequency band filter agents are triazine derivatives substituted in an asymmetric form. A particular object is 2,4-bis-{[4- (2-ethyl-hexyloxy) -2-hydroxy] -phenyl}-, commercially available under the trade name Tinosorb S from CIBA Chemicals. 6- (4-methoxyphenyl) -1,3,5-triazine (INCI: anisotriazine).

  Another advantageous water-soluble UV filter agent is designated by the INCI name: terephthalidine dicamphor sulfonic acid (Case No: 90457-82-2) and is available, for example, from the company Chimex under the trade name Mexoryl SX. 3,3 ′-(1,4-phenylenedimethylene) bis (7,7-dimethyl-2-oxo-bicyclo- [2.2.1] hept-1-yl) methanesulfonic acid and its sodium salt, potassium Salt, or its triethanolammonium salt.

  A specific embodiment according to the invention is a sprayable oil-in-water emulsion, which has a sunscreen index of SPF ≧ 40, in particular SPF ≧ 50, or SPF ≧ 60, from 15% to 40%. A sunscreen formulation containing in particular 20% to 30% oil phase, the formulation comprising (a) 5% to 30% in the oil phase, in particular 10% to 30%, further 10% A lipophilic UV filter agent in an amount of from 30% to 30%, and even from 10% to 20%, and (b) from 0.1% to 10%, in particular from 0.2% to 5%, further 0 It contains from 3% to 3% alkyl glycol, preferably caprylyl glycol.

  Another embodiment of the invention is a sprayable oil-in-water emulsion, which has a sunscreen index of SPF ≧ 40, in particular SPF ≧ 50, or SPF ≧ 60, from 15% to 40%. Sunscreen preparations containing in particular 20% to 30% oil phase, wherein (a) 5% to 30%, in particular 10% to 30%, further 10% to 30% in the oil phase. %, Further 10% to 20% of lipophilic UV filter agent, and (b) 1% to 10%, especially 1% to 5%, further 2% to 5% hydrophilic And (c) 0.1% to 10%, in particular 0.2% to 5%, further 0.3% to 3% alkyl glycol, preferably at least 0.3% alkyl glycol. % Caprylyl Gris It is intended to include Lumpur.

  Another embodiment of the invention is a sprayable oil-in-water emulsion, which has a sunscreen index of SPF ≧ 40, in particular SPF ≧ 50, from 15% to 40%, in particular from 20%. A sunscreen formulation containing up to 30% oil phase, comprising: (a) in the oil phase from 5% to 30%, in particular from 10% to 30%, even from 10% to 30%, and even more A lipophilic UV filter agent contained in an amount of 10% to 20%; and (b) a hydrophilic UV filter agent of 1% to 10%, particularly 1% to 5%, and further 2% to 5%. (C) 0.5% to 15%, in particular 1% to 10%, further 1% to 5% of inorganic pigments, in particular titanium dioxide or coated titanium dioxide, and (d) 0.1% to 10%. %, Especially 0.2% to 5%, and further 0 Alkyl glycol 3% to 3%, preferably containing caprylyl glycol.

  Another embodiment of the invention is a sprayable oil-in-water emulsion, which has a sunscreen index of SPF ≧ 40, in particular SPF ≧ 50, from 15% to 40%, in particular from 20%. A sunscreen formulation containing up to 30% oil phase, comprising: (a) in the oil phase from 5% to 30%, in particular from 10% to 30%, even from 10% to 30%, and even more A lipophilic UV filter agent contained in an amount of 10% to 20%; and (b) a hydrophilic UV filter agent of 1% to 10%, especially 1% to 5%, and further 2% to 5%. (C) 0.5% to 15%, in particular 1% to 10%, further 1% to 5% of inorganic pigments, in particular titanium dioxide or coated titanium dioxide, and (d) 0.1% to 15%. %, Especially from 0.5% to 10%, % To 10% latex particles, especially hollow latex particles, and (e) 0.1% to 10%, especially 0.2% to 5%, and further 0.3% to 3% alkyl glycol Preferably, it contains caprylyl glycol.

  Spray formulations having a sunscreen index with SPF ≧ 40, in particular SPF ≧ 50, are preferably both benzotriazole and asymmetrically substituted triazine derivatives, in particular the trade name Tinosorb M and the trade name Tinosorb. ) It contains both S.

  Unlike the soluble UV filter substances described above, insoluble sunscreen pigments, ie finely dispersed metal oxides or metal salts, can also be added. Examples of particularly suitable metal oxides are zinc oxide and titanium dioxide and iron, zirconium, silicon, manganese, aluminum and cerium oxides, and mixtures thereof. Usable salts include silicates (talc), barium sulfate or zinc stearate. The particle size of these pigments is sufficiently small, for example less than 100 nm, in particular between 5 and 50 nm, and further between 15 and 30 nm. The particles can be spherical, but can also have other shapes such as an elliptical shape or a similar shape. The surface of the pigment is made hydrophilic, for example, or made hydrophobic. Typical examples are coated with titanium dioxide, such as titanium dioxide T805 (available from Degussa) or Eusolex® T2000 (Merck). Silicones, in particular trialkoxyoctylsilane or simethicone, can be used as hydrophobic coatings. So-called micro or nano level pigments are particularly attractive for use in sunscreen products.

  Other components that can be added are latex particles, in particular latex particles having an average particle size from 100 nm to 400 nm. Of particular interest are the hollow latex particles described in US Pat. No. 5,663,213, which corresponds to EP 761,201. Particularly preferred are latex particles formed from styrene / acrylate copolymers and available from Rohm & Haas under the trade designation “Alliance SunSphere”. These commercially available products usually have a content of “active ingredient” (ie pure latex) of from about 25% to about 27%, and when used in the emulsions of this invention, The amount of commercial product needs to be recalculated in the effect of the amount of latex particles present in the emulsion.

  Unlike both groups of first lightfast filter agents described above, a second lightfastness factor can also be used. These light-resistant factors belong to the class of antioxidants, and their activity is based on blocking or reducing the photochemical process that occurs upon penetration into the skin by sunlight.

  Typical examples of the second light fastness factor are, for example, glycine, histidine, tyrosine and tryptophan and amino acids including amino acid derivatives; imidazoles (eg urocanic acid) and their derivatives; D, L-carnosine, D-carnosine, L -Peptides such as carnosine and derivatives thereof (eg anserine). Other drugs that can be used are carotenoids, carotenes (eg, α-carotene, β-carotene and lycopene) and their derivatives; chlorogenic acid and its derivatives; lipoic acid and its derivatives (eg, dihydrolipoic acid), gold thioglucose Propylthiouracil and other thiols (e.g. thioredoxin, glutathione, cysteine, cystamine and glycosyl esters, N-acetyl esters, methyl esters, ethyl esters, propyl esters, amyl esters, butyl esters, And lauryl esters, palmitoyl esters, oleyl esters, γ-linoleyl esters, cholesteryl esters and glyceryl esters) and salts thereof. Other examples are dilauryl thiodipropionate, distearyl thiopropionate, thiodipropionic acid and derivatives thereof (eg esters, ethers, peptides, lipids, nucleotides, nucleosides and salts), Sulfoximine compounds (for example, butionine sulfoximine, homocysteine sulfoximine, butionine sulfone, pentathion sulfoximine, hexathion sulfoximine and heptathione sulfoximine). These second agents are usually formulated at very low concentrations (eg, picomoles to micromoles per kg).

  Other second agents (usually used at low concentrations as described above) include chelating agents (eg, α-hydroxy fatty acids, palmate acid, phytic acid, lactoferrin), α-hydroxy acids (eg, citrate). Acid, lactic acid, malic acid), humic acid, bile acid, bile extract, bile pigment, biliverdin, ethylenediaminetetraacetic acid (EDTA), ethyleneglycosebis (2-aminoethylether) tetraacetic acid (EGTA) and derivatives thereof, Unsaturated fatty acids and derivatives thereof such as γ-linolenic acid, linoleic acid, oleic acid, folic acid and derivatives thereof; ubiquinones and ubiquinols and derivatives thereof, vitamin C and derivatives thereof (eg ascorbyl palmitate, magnesium ascorbate) Phosphate, ascorbic acid aceta ), Tocopherol and derivatives thereof (eg vitamin E acetate), vitamin A and derivatives thereof (eg vitamin A palmitate), benzoic acid, rutinic acid and its derivatives coniferyl benzoate, α-glycosyl rutin, ferulic acid, furfuryl ridging Lucitol, carnosine, butylhydroxytoluene, butylhydroxyanisole, nordihydroguaiacic acid, nordihydroguaiaretic acid, trihydroxybutylphenone, ureic acid and their derivatives, mannose and its derivatives, dismutase superoxide, zinc And zinc derivatives such as zinc oxide and zinc sulfate, selenium and derivatives thereof (eg selenomethionine), stilbene and derivatives thereof (eg stilbene oxide, trans-stilbene oxide), and Are all suitable derivatives Luo UV filter agents.

  The sprayable emulsions of this invention can also be used as self-tanning sprays. In this case, dihydroxyacetone can be added.

  The oil phase and / or aqueous phase is 1% (w / w) to 20% (w / w), preferably 5% (w / w) to 15% (w / w), based on the total amount of emulsion. One and more humectants can also be included that can be present in amounts up to and more preferably from 5% (w / w) to 10% (w / w).

  Suitable humectants are, for example, amino acids, pyrrolidone carbonic acid, lactic acid and its salts, lactitol, urea and urea derivatives, ureic acid, glucosamine, creatinine, collagen, chitosan or chitosan salt / chitosan derivative hydrolysates, and in particular ethylene glycol , Propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, erythritol, 1,2,6-hexanetriol, PEG-4, PEG-6, PEG-8, PEG-10, PEG-12, PEG-14, Polyols and polyol derivatives such as polyethylene glycol such as PEG-16, PEG-18, PEG-20, PEG-135, PEG-150, etc., saccharides and saccharide derivatives (eg fructose, glucose, maltose, maltose Mannitol, sorbit, sorbylsilane diol, sucrose, trehalose, xylose, xylit, glucuronic acid and its salts), ethoxylated sorbitol, honey and hydrogenated honey, hydrogenated starch hydrolysate, and hydrogenated wheat protein, water Degradable milk protein, lecithin, pitanetriol, hyaluronic acid and salts thereof, and PEG-20 acetic acid copolymer. Particularly preferred humectants are glycerin, diglycerin and triglycerin.

  The emulsion of the present invention comprises synthetic aromatic substances or flower parts (lily, lavender, rose, jasmine, neroli, ylang ylang), stems and leaves (geranium, patchouli, petitgren), fruits (anise, coriander, caraway, Kade), bark (bergamot, lemon, orange), root (matis, angelica, celery, cardamom, costas, iris, calmas), timber (pine, sandalwood, guayak, cedar, rose), herbaceous and herbaceous (Taragon, lemongrass, sage, thyme), needles and branches (spruce, fir, pine, mountain pine), resin and balm (galvanum, elemi, benzoin, myrrh, olibanum) Perfume oil that may be a mixture of fragrances of

  The emulsions of this invention may contain one or more preservatives. Preservatives are useful to substantially prevent microbial degradation. Examples of preservatives are those containing parabens such as phenoxyethanol, iodopropylbutyl carbamate (IPBC), sodium benzoate, methylparaben, ethylparaben and propylparaben. Other examples of preservatives are from 1654 to 1655 of the International Cosmetic Ingredient Dictionary and Handbook Wenninger and McEwen (CTFA, 7th edition, 1997), hereinafter referred to as the “Cosmetic Handbook” It is published in. The composition may contain from about 0.01% to about 10% (more preferably from about 0.5% to about 5%) of a preservative.

  Antioxidants and / or chelating agents can also be used to increase the shelf life and stability of the composition. Antioxidant compounds and derivatives thereof include water-soluble antioxidants such as sulfhydryl compounds and their derivatives (eg, isomeric sodium bisulfite and N-acetylcysteine), lipoic acid, dihydrolipoic acid, resveratrol, acetylcysteine or lactoferrin, ascorbine Including but not limited to acids and ascorbic acid derivatives (eg, ascorbyl palmitate, ascorbic acid polypeptides). Oil soluble antioxidants include, but are not limited to, butylhydroxytoluene, retinoids (eg, retinol and retinyl palmitate), tocopherol (eg, tocopherol acetate), tocotrienols and ubiquinone. Natural extracts containing antioxidants include extracts containing flavonoids and isoflavonoids and their derivatives (eg genistein and diadezein), extracts containing resveratrol and the like . Examples of such natural extracts are those containing grape seed, green tea, pine bark, propolis and legume extracts. Other examples of antioxidants are found on pages 1612 to 1613 of the cosmetic handbook. Compositions of the invention include the antioxidant in an amount from about 0.001% to about 20% (eg, from about 0.01% to about 10%) by weight of the composition. Can do.

  Chelating agents can also be added, for example, to help stabilize the emulsions of this invention. Examples of chelating agents include ethylenediaminetetraacetic acid and its derivatives (eg, ethylenediaminetetraacetic acid disodium and ethylenediaminetetraacetic acid dipotassium), iniferine (trade name), lactoferrin and citric acid. Other examples of chelating agents are listed on page 1626 of the cosmetic handbook. The emulsions of this invention can include the chelating agent in an amount from about 0.001% to about 20% (eg, from about 0.01% to about 10%) by weight of the composition. .

  The emulsion of the present invention is produced by the following known method for producing an oil-in-water emulsion. In general, as soon as the oil phase and the aqueous phase are produced separately, the oil phase is added to the aqueous phase, or conversely, the aqueous phase is added to the oil phase and immediately stirred vigorously to make an emulsifier. To do. If desired, additional components may be added to the emulsifier. If desired, the emulsification process may be performed at an elevated temperature, for example, 50 ° C. or higher, or 70 ° C. or higher.

  The sprayable emulsifiers according to the invention are used, for example, for emulsions with a relatively high content of lipophilic active ingredients, for example sunscreens with a high SPF (sunscreen index), when a high content of lipids is required. It can be used in the case of a formulation or a propellant intended for injection oil.

The following examples are given to illustrate the invention and do not limit the invention to the examples.

Specific embodiments of the present invention are as follows.
(1) A sprayable oil-in-water emulsion comprising at least 15% oil phase, the formulation containing at least 0.1% alkyl glycol.
(2) The sprayable oil-in-water emulsion according to embodiment (1), comprising at least 5% lipophilic active ingredient.
(3) An embodiment (2) which is a sprayable sunscreen formulation comprising at least 5% UV filter agent, comprising at least 15% oil phase, the formulation comprising at least 0.3% alkyl glycol. ) Sprayable oil-in-water emulsions.
(4) The sprayable oil-in-water emulsion according to embodiment (3), having a sunscreen index of SPF ≧ 40, more preferably SPF ≧ 50, or even more preferably SPF ≧ 60.
(5) The sprayable oil-in-water emulsion according to any one of embodiments (1) to (4), comprising at least 20%, further at least 25%, and even at least 30% oil phase. .

(6) The sprayable of any one of embodiments (1) to (5), comprising at least 0.3% alkyl glycol and further containing at least 0.3% alkyl glycol. Oil-in-water emulsion.
(7) Contains 15% to 40%, especially 20% to 30% oil phase, further 0.1% to 10%, especially 0.2% to 5%, further 0.3% The sprayable oil-in-water emulsion of embodiment (1), comprising up to 3% alkyl glycol.
(8) contains 15% to 40%, in particular 20% to 30% of the oil phase; (a) 5% to 30%, in particular 10% to 30%, further 10 in the oil phase. One or more lipophilic active ingredients contained in an amount of from 30% to 30%, and even from 10% to 20%, and (b) from 0.1% to 10%, in particular from 0.2% to 5 The sprayable oil-in-water emulsion according to embodiment (1), comprising up to 5%, further from 0.3% to 3% alkyl glycol, preferably caprylyl glycol.
(9) a sunscreen formulation, containing 15% to 40%, especially 20% to 30% oil phase; (a) from 5% to 30%, especially 10% in the oil phase; An oleophilic UV filter agent contained in an amount of up to 30%, further 10% to 30%, and further 10% to 20%, and (b) from 0.1% to 10%, in particular from 0.2%. The sprayable oil-in-water emulsion according to embodiment (1), comprising up to 5%, further 0.3% to 3% alkyl glycol, preferably caprylyl glycol.
(10) The sprayable oil-in-water emulsion according to any one of embodiments (1) to (9), wherein the alkyl glycol is caprylyl glycol.

(11) has a sunscreen index of SPF ≧ 40, in particular SPF ≧ 50, contains an oil phase of 15% to 40%, in particular 20% to 30%, (a) 5 in the oil phase An oleophilic UV filter agent contained in an amount of from 10% to 30%, in particular from 10% to 30%, further from 10% to 30%, and even from 10% to 20%; Up to 1% to 5%, in particular 2% to 5% hydrophilic UV filter agent, and (c) from 0.1% to 10%, especially from 0.2% to 5%, and further to 0. The sprayable oil-in-water emulsion of embodiment (1), comprising from 3% to 3% alkyl glycol, preferably caprylyl glycol when the alkyl glycol is at least 0.3%.
(12) (a) Lipophilicity contained in the oil phase in an amount of 5% to 30%, especially 10% to 30%, further 10% to 30%, and further 10% to 20%. UV filter agent, (b) 1% to 10%, in particular 1% to 5%, further 2% to 5% hydrophilic UV filter agent, and (c) 0.5% to 15%, In particular from 1% to 10%, further from 1% to 5% inorganic pigments, in particular titanium dioxide or coated titanium dioxide, and (d) from 0.1% to 10%, in particular from 0.2% to 5%, The sprayable oil-in-water emulsion according to embodiment (11), further comprising 0.3% to 3% alkyl glycol, preferably caprylyl glycol.

Claims (10)

  Sprayable oil-in-water emulsion comprising at least 15% oil phase, the formulation containing at least 0.1% alkyl glycol.   2. A sprayable oil-in-water emulsion according to claim 1, comprising at least 5% lipophilic active ingredient.   A sprayable sunscreen formulation comprising at least 5% UV filter agent, comprising at least 15% oil phase, the formulation containing at least 0.3% alkyl glycol. Oil-in-water emulsion.   4. A sprayable oil-in-water emulsion according to claim 3, having a sunscreen index of SPF ≧ 40, more preferably SPF ≧ 50, or even more preferably SPF ≧ 60.   The sprayable oil-in-water emulsion according to any one of claims 1 to 4, containing at least 20%, further at least 25%, and even at least 30% oil phase.   6. A sprayable oil-in-water emulsion according to any one of claims 1 to 5, containing at least 0.3% alkyl glycol and further containing at least 0.3% alkyl glycol.   Contains 15% to 40%, especially 20% to 30% oil phase, further 0.1% to 10%, especially 0.2% to 5%, further 0.3% to 3% The sprayable oil-in-water emulsion of claim 1, comprising   15% to 40%, in particular 20% to 30% oil phase, (a) 5% to 30%, in particular 10% to 30%, further 10% to 30% in the oil phase. One or more lipophilic active ingredients included in an amount of up to 10%, and even from 10% to 20%, and (b) from 0.1% to 10%, in particular from 0.2% to 5%, The sprayable oil-in-water emulsion according to claim 1, further comprising 0.3% to 3% of an alkyl glycol, preferably caprylyl glycol.   A sunscreen formulation, containing 15% to 40%, especially 20% to 30% oil phase, (a) 5% to 30%, especially 10% to 30%, in the oil phase A lipophilic UV filter agent further contained in an amount from 10% to 30%, and further from 10% to 20%, and (b) from 0.1% to 10%, in particular from 0.2% to 5% The sprayable oil-in-water emulsion of claim 1, further comprising 0.3% to 3% alkyl glycol, preferably caprylyl glycol. The sprayable oil-in-water emulsion according to any one of claims 1 to 9, wherein the alkyl glycol is caprylyl glycol.