WO2022204772A1 - Method for acting on arthropods and/or nematodes using sequences of extremely low frequencies and guide frequencies - Google Patents
Method for acting on arthropods and/or nematodes using sequences of extremely low frequencies and guide frequencies Download PDFInfo
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- WO2022204772A1 WO2022204772A1 PCT/BR2022/050111 BR2022050111W WO2022204772A1 WO 2022204772 A1 WO2022204772 A1 WO 2022204772A1 BR 2022050111 W BR2022050111 W BR 2022050111W WO 2022204772 A1 WO2022204772 A1 WO 2022204772A1
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- arthropods
- nematodes
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- 241000238421 Arthropoda Species 0.000 title claims abstract description 80
- 241000244206 Nematoda Species 0.000 title claims abstract description 77
- 238000000034 method Methods 0.000 title claims abstract description 34
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 22
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 22
- 150000001413 amino acids Chemical class 0.000 claims abstract description 20
- 239000005556 hormone Substances 0.000 claims abstract description 13
- 229940088597 hormone Drugs 0.000 claims abstract description 13
- 229910052729 chemical element Inorganic materials 0.000 claims abstract description 12
- 239000002858 neurotransmitter agent Substances 0.000 claims abstract description 12
- 230000004936 stimulating effect Effects 0.000 claims abstract description 11
- 239000002773 nucleotide Substances 0.000 claims abstract description 9
- 125000003729 nucleotide group Chemical group 0.000 claims abstract description 9
- 201000010099 disease Diseases 0.000 claims abstract description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 7
- 230000008569 process Effects 0.000 claims description 22
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 20
- 230000009471 action Effects 0.000 claims description 18
- 230000008827 biological function Effects 0.000 claims description 11
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- 230000002401 inhibitory effect Effects 0.000 claims description 9
- 230000015572 biosynthetic process Effects 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 7
- 150000002632 lipids Chemical class 0.000 claims description 7
- 230000035772 mutation Effects 0.000 claims description 7
- 238000003786 synthesis reaction Methods 0.000 claims description 7
- UPEZCKBFRMILAV-JNEQICEOSA-N Ecdysone Natural products O=C1[C@H]2[C@@](C)([C@@H]3C([C@@]4(O)[C@@](C)([C@H]([C@H]([C@@H](O)CCC(O)(C)C)C)CC4)CC3)=C1)C[C@H](O)[C@H](O)C2 UPEZCKBFRMILAV-JNEQICEOSA-N 0.000 claims description 5
- UPEZCKBFRMILAV-UHFFFAOYSA-N alpha-Ecdysone Natural products C1C(O)C(O)CC2(C)C(CCC3(C(C(C(O)CCC(C)(C)O)C)CCC33O)C)C3=CC(=O)C21 UPEZCKBFRMILAV-UHFFFAOYSA-N 0.000 claims description 5
- UPEZCKBFRMILAV-JMZLNJERSA-N ecdysone Chemical compound C1[C@@H](O)[C@@H](O)C[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@@H]([C@H](O)CCC(C)(C)O)C)CC[C@]33O)C)C3=CC(=O)[C@@H]21 UPEZCKBFRMILAV-JMZLNJERSA-N 0.000 claims description 5
- 229930014550 juvenile hormone Natural products 0.000 claims description 5
- 239000002949 juvenile hormone Substances 0.000 claims description 5
- 150000003633 juvenile hormone derivatives Chemical class 0.000 claims description 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 4
- 230000004098 cellular respiration Effects 0.000 claims description 4
- 230000008260 defense mechanism Effects 0.000 claims description 3
- 230000007123 defense Effects 0.000 claims description 2
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- 230000012010 growth Effects 0.000 claims description 2
- 230000008685 targeting Effects 0.000 claims 4
- 230000006698 induction Effects 0.000 claims 2
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- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
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- 230000000694 effects Effects 0.000 abstract description 6
- 239000000126 substance Substances 0.000 description 15
- 241000238631 Hexapoda Species 0.000 description 14
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 10
- 210000005036 nerve Anatomy 0.000 description 8
- 102000012440 Acetylcholinesterase Human genes 0.000 description 6
- 108010022752 Acetylcholinesterase Proteins 0.000 description 6
- 108010062745 Chloride Channels Proteins 0.000 description 6
- 102000011045 Chloride Channels Human genes 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 6
- 229940022698 acetylcholinesterase Drugs 0.000 description 6
- 229940088598 enzyme Drugs 0.000 description 6
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 5
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 5
- 238000005728 strengthening Methods 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 4
- 210000000225 synapse Anatomy 0.000 description 4
- 102000000452 Acetyl-CoA carboxylase Human genes 0.000 description 3
- 108010016219 Acetyl-CoA carboxylase Proteins 0.000 description 3
- 206010001497 Agitation Diseases 0.000 description 3
- 108010018763 Biotin carboxylase Proteins 0.000 description 3
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 3
- 108010052164 Sodium Channels Proteins 0.000 description 3
- 102000018674 Sodium Channels Human genes 0.000 description 3
- 229930195712 glutamate Natural products 0.000 description 3
- 230000001846 repelling effect Effects 0.000 description 3
- 241000255925 Diptera Species 0.000 description 2
- 206010061217 Infestation Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000003116 impacting effect Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 230000029052 metamorphosis Effects 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 230000035790 physiological processes and functions Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 230000002407 ATP formation Effects 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
- 229960004373 acetylcholine Drugs 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01M—CATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
- A01M1/00—Stationary means for catching or killing insects
- A01M1/22—Killing insects by electric means
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P5/00—Nematocides
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P7/00—Arthropodicides
Definitions
- the desired effect is achieved by strengthening or attenuating the bonds between chemical elements and their combinations, including the constituent elements of nucleotides, amino acids, hormones and neurotransmitters, among others, related to arthropods and/or nematodes and/or their hosts.
- arthropods and/or nematodes In general, the degree of genetic mutation of arthropods and/or nematodes, the main cause of their resistance to chemicals, makes it quite complex and costly to define a solution for eliminating or reducing their impact on human, animal and plant health , and crop productivity.
- arthropod and/or nematode control There are currently two most common types of solutions for arthropod and/or nematode control available: chemical and biological. Both have been used, but they can present undesirable effects such as, diverse side effects in humans, leaving residues in food of plant and animal origin (with the potential to cause diseases in humans and animals), contamination of soils, rivers, lakes and groundwater, intoxication of professionals who apply the products to crops and animals, among others.
- they may have low efficiency due to frequent mutations of arthropods and/or nematodes and high selection pressure for populations resistant to chemicals.
- the invention BR 1020190259582 - PRODUCT AND PROCESS FOR ACTION IN BIOLOGICAL ORGANISMS THROUGH EXTREMELY LOW FREQUENCIES of 12/07/2019 reveals a product and process for using extremely low frequency sequences for use in organisms.
- said invention does not define specific processes for the use of this procedure in the case of arthropods and/or nematodes that cause and/or transmit diseases, and/or cause productivity losses, in humans, animals and plants.
- the invention CN211482636 - INSECT EXPELLING CIRCUIT AND WATER PURIFIER of 08/21/2019 reveals a utility model referring to the field of insect expelling control, and features an insect expulsion circuit and a water purifier.
- An ultrasonic frequency signal and a low frequency signal are respectively output to an ultrasonic driving circuit and a low frequency electromagnetic wave excitation circuit through a processor; and the ultrasonic transducer and transmission circuit are driven to transmit ultrasonic waves and transmit low frequency electromagnetic waves, and the ultrasonic waves and low frequency electromagnetic waves can be transmitted simultaneously or alternately, so that the effects caused by a single Ultrasonic insect expulsion can be effectively avoided, continuous insect expulsion effect is achieved, and user experience is improved.
- the invention does not deal with the use of Extremely Low Frequency (ELF) sequences in the range of 0 to 100Hz, and does not specify the molecular targets that are reached by the frequencies, which can also act collaterally on beneficial arthropods and/or nematodes when environment to which it will be applied.
- ELF Extremely Low Frequency
- the invention NZ588814 - METHOD OF INSECT CONTROL of 10/27/2010 discloses a method of controlling insects by diffusing frequency sweep sound waves to cause malfunction of the wing beating system of flying insects. The method comprises determining the frequency range of insect wing beats, then generating a series of single frequency sound waves that cover the entire frequency range of insect wing beats.
- Single frequency sound waves being from low frequency to high frequency are linked to form an ascending, descending and random ordered sound series.
- the sound series are also linked together to form frequency-swept sound tracks that can be recorded digitally.
- the diffusion of sound tracks is carried out in such a way that the SPL (sound pressure level) of the sound waves reaches a value greater than 2.0 Pa (ie 100 dB).
- said invention does not deal with the use of Extremely Low Frequency (ELF) sequences in the range of 0 to 100Hz, and does not specify the molecular targets that are reached by the frequencies, which can also act collaterally on beneficial arthropods and/or nematodes when environment to which it will be applied.
- EMF Extremely Low Frequency
- the invention US20060198245 - ELECTRONIC INSECT REPELLING DEVICE of 02/03/2005 discloses a personal electronic device for repelling insects and is an electronic circuit supported on the underside of a hat of a hat that produces an acoustic signal directed towards the body of a person wearing the hat.
- the sonic signal has a frequency that repels insects, particularly mosquitoes.
- the sonic signal is generated by a battery-operated oscillator circuit, which drives an electro-acoustic transducer to generate the acoustic signal.
- the acoustic transducer is mounted relative to the hat so that substantially all exposed areas of the person wearing the hat are radiated with sonic energy.
- the sonic signal has essentially the same characteristics as the sound of a male mosquito.
- said invention is restricted to the emission of a sound signal with the function of repelling insects and does not explore other ways of attack such as reproduction, motility and other biological functions.
- the aim is to alter the natural biological function of the target proteins with the objective of stimulating the development or inhibiting the infection (infestation and/or occurrence) and/or multiplication of the arthropod and/or nematode and/or modifying the defense mechanisms of the animal. host against the arthropod and/or nematode.
- [0012] Act on nucleotide sequences in order to prevent or stimulate the gene expression of proteins important for physiological processes essential for life, multiplication and/or infection (infestation and/or occurrence) of the arthropod and/or nematode and/ or modify the host's defense mechanisms against the arthropod and/or nematode.
- arthropods and/or nematodes Act on elements other components of arthropods and/or nematodes, such as hormones, lipids and neurotransmitters, among others from chemical elements and/or specific chemical compounds and/or their combinations for each arthropod and/or nematode or group of arthropods or nematodes, including their variations and/or mutations, and/or their hosts, in order to stimulate or inhibit, totally or partially, their biological function. All these strategies use the same technique used here.
- elements other components of arthropods and/or nematodes such as hormones, lipids and neurotransmitters, among others from chemical elements and/or specific chemical compounds and/or their combinations for each arthropod and/or nematode or group of arthropods or nematodes, including their variations and/or mutations, and/or their hosts, in order to stimulate or inhibit, totally or partially, their biological function. All these strategies use the same technique used here.
- the purpose of the technique demonstrated here is to inhibit or stimulate biological functions or modify the properties of the elements, or chemical compounds, defined in the attack strategies listed above by applying extremely low frequency sequences and a set of predefined driving frequencies.
- the way of acting developed and revealed in this technique is based on the application of the technique of extremely low frequency sequences, that is, frequencies in the open range between 0 and 100 Hertz (limits not included).
- Each set of frequency sequences is composed of one or more targets and one or more specific drivers for each arthropod and/or nematode species and/or its variations and mutations. This makes this set of specific application of arthropods and/or nematodes and of biological and/or physiological functions chosen in them.
- This invention discloses those application processes which are illustrated in Figures 2 and 4.
- Each target and driver combination is designed to define a mathematically unique solution.
- this invention makes use of one or more sequences of previously determined frequencies (each with target and driver determining a unique solution) and validated in the laboratory, to generate the decrease or increase of the interatomic distance of the elements chemicals that form the target amino acids, altering the conformation of the protein in question and consequently its biological function.
- this invention makes use of one or more sequences of frequencies previously determined (each with target and driver determining a unique solution) and validated in the laboratory, to generate the decrease or increase of the interatomic distance of the elements chemicals that form the target nucleotides, altering the conformation of these nucleotides and consequently their biological function.
- this invention makes use of one or more sequences of previously determined frequencies (each with target and driver determining a unique solution) and validated in the laboratory, to generate the decrease or increase of the interatomic distance of the target chemical elements and/or chemical compounds (such as hormones, lipids and neurotransmitters, among others), altering their conformation and consequently their biological properties and/or functions.
- target chemical elements and/or chemical compounds such as hormones, lipids and neurotransmitters, among others
- a first preferred embodiment deals with the application of strategy 1 (acting on amino acids) that targets the amino acid sequences of the Acetylcholinesterase (AChE) enzyme of arthropods and/or nematodes.
- the frequency sequences will act according to their driving frequencies on the amino acid sequences that form the different possibilities of active site (binding site) of the Acetylcholinesterase (AChE) enzyme of arthropods and/or nematodes.
- Acetylcholinesterase (AChE) enzyme of arthropods and/or nematodes will be prevented or hindered, causing hyperexcitation in nerve synapses due to the large amount of the neurotransmitter acetylcholine, damaging the nerve transmission of arthropods and/or nematodes.
- AChE Acetylcholinesterase
- a second preferred modality deals with the application of strategy 1 (acting on amino acids) that targets the amino acid sequences of the chloride channel activated by GABA (Gamma-aminobutyric acid) of arthropods and/or nematodes.
- the frequency sequences will act according to their driving frequencies on the amino acid sequences that form the different possibilities of active site (binding site) of GABA (gamma-aminobutyric acid) to the chloride channel of arthropods and/or nematodes.
- a third preferred modality deals with the application of strategy 1 (acting on amino acids) that target the amino acid sequences of the sodium channels of arthropods and/or nematodes.
- the frequency sequences will act according to their driving frequencies on the amino acid sequences that form the different possibilities of active site (binding site) of the regulatory neurotransmitters to the sodium channels of arthropods and/or nematodes.
- the binding of neurotransmitters regulating the sodium channels of arthropods and/or nematodes will be prevented or hindered, causing hyperexcitation and/or blockage in nerve synapses, damaging the nerve transmission of arthropods and/or nematodes.
- a fourth preferred modality deals with the application of strategy 1 (acting on amino acids) that targets the amino acid sequences of the ATP synthase enzyme of arthropods and/or nematodes.
- the frequency sequences will act according to their driving frequencies on the amino acid sequences that form the different possibilities of active site (binding site) of the ATP synthase enzyme of arthropods and/or nematodes.
- the action of the ATP synthase enzyme of arthropods and/or nematodes will be prevented or hindered, causing inhibition of ATP synthesis in mitochondria, damaging the nerve transmission of arthropods and/or nematodes.
- a fifth preferred embodiment deals with the application of strategy 1 (acting on amino acid) which targets the amino acid sequences of the Acetyl CoA Carboxylase enzyme of arthropods and/or nematodes.
- the frequency sequences will act according to their driving frequencies on the amino acid sequences that form the different possibilities of active site (binding site) of the Acetyl CoA Carboxylase enzyme of arthropods and/or nematodes.
- a sixth preferred modality deals with the application of strategy 2 (action on nucleotides) that targets the sequence of nucleotides ( Figure 3) that participate in the metabolism of nucleic acids of arthropods and/or nematodes.
- the frequency sequences will act according to their driving frequencies on the nucleotide sequences, preventing the translation ( Figure 4) of the coding region of proteins that participate in the metabolism of nucleic acids of arthropods and/or nematodes.
- a seventh preferred modality deals with the application of strategy 3 (acting on chemical elements and/or chemical compounds, such as hormones, lipids and neurotransmitters, among others) that targets the juvenile hormone (Figure 5) of arthropods and/or arthropods. or nematodes.
- strategy 3 acting on chemical elements and/or chemical compounds, such as hormones, lipids and neurotransmitters, among others
- the frequency sequences will act according to their driving frequencies on the chemical sequences that form the juvenile hormone of arthropods and/or nematodes.
- An eighth preferred embodiment deals with the application of strategy 1 (acting on amino acids) that targets the amino acid sequences of the chloride channel blocked by Glutamate of arthropods and/or nematodes ( Figure 1).
- the frequency sequences will act according to their driving frequencies on the amino acid sequences that form the different possibilities of active site (binding site) of Glutamate to the chloride channel of arthropods and/or nematodes.
- the binding of Glutamate to the chloride channels ( Figure 2) of arthropods and/or nematodes will be prevented or difficult, causing paralysis of nerve synapses, damaging the nerve transmission of arthropods and/or nematodes.
- a ninth preferred modality deals with the application of strategy 3 (acting on chemical elements and/or chemical compounds, such as hormones, lipids and neurotransmitters, among others) that target the ecdysone hormone of arthropods and/or nematodes.
- strategy 3 acting on chemical elements and/or chemical compounds, such as hormones, lipids and neurotransmitters, among others
- the frequency sequences will act according to their driving frequencies on the chemical sequences that form the ecdysone hormone of arthropods and/or nematodes.
- a tenth preferred embodiment deals with the application of strategy 1 (acting on amino acids) that targets the amino acid sequences, in whole or in part, that make up the proteins of the cellular respiration complex.
- the frequency sequences will act according to their driving frequencies on the amino acid sequences that form the active site (binding site) of the proteins mentioned above.
- the cellular respiration of arthropods and/or nematodes will be inhibited, impeded or hampered, totally or partially.
- An eleventh preferred embodiment deals with the application of strategy 1 (acting on amino acids) that targets the amino acid sequences, in whole or in part, that make up the proteins that act in the synthesis of amino acids and proteins.
- the frequency sequences will act according to their driving frequencies on the amino acid sequences that form the active site (binding site) of the proteins that act in the synthesis of amino acids and proteins of the arthropod and/or nematode.
- the synthesis of amino acids and proteins of arthropods and/or nematodes will be prevented or hindered.
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- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Insects & Arthropods (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Toxicology (AREA)
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- Agricultural Chemicals And Associated Chemicals (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
Method for acting on chemical elements and combinations thereof, including proteins, DNA, RNA, hormones and neurotransmitters of arthropods and/or nematodes that cause and/or transmit diseases, and/or that cause productivity losses, and/or stimulating the defence of the hosts thereof against such arthropods and/or nematodes by transmitting sequences of extremely low frequencies defined using targets and a set of specific guides that act on specific sequences of amino acids and/or nucleotides, inter alia, of the arthropods and/or nematodes and/or hosts thereof. The desired effect is to strengthen or weaken the bonds between the chemical elements and the combinations thereof, including the component elements of the nucleotides, amino acids, hormones and neurotransmitters, inter alia, related to the arthropods and/or nematodes and/or the hosts thereof.
Description
PROCESSO PARA ATUAÇÃO EM ARTRÓPODES E/OU NEMATOIDES POR MEIO DE SEQUÊNCIAS DE FREQUÊNCIAS EXTREMAMENTE BAIXAS E FREQUÊNCIAS DIRECIONADORAS PROCESS FOR WORKING ON ARTHROPODS AND/OR NEMATOIDS THROUGH EXTREMELY LOW FREQUENCY SEQUENCES AND DRIVING FREQUENCIES
RELATÓRIO DESCRITIVO CAMPO DA INVENÇÃO DESCRIPTIVE REPORT FIELD OF THE INVENTION
[0001] Processo para atuação em elementos químicos e suas combinações, incluindo proteínas, DNA, RNA, hormônios e neurotransmissores dos artrópodes e/ou nema- toides causadores e/ou transmissores de doenças, e/ou causadores de perdas de produtividade, e/ou atuação estimulando a defesa de seus hospedeiros contra estes artrópodes e/ou nematoides, por meio da transmissão de sequências de frequências extremamente baixas definidas a partir de alvos e conjunto de direcionadores especí ficos que atuarão sobre determinadas sequências de aminoácidos e/ou nucleotídeos, entre outros, dos artrópodes e/ou nematoides e/ou de seus hospedeiros. O efeito dese jado é conseguido fortalecendo ou atenuando as ligações entre os elementos químicos e suas combinações, incluindo os elementos constituintes dos nucleotídeos, aminoáci dos, hormônios e neurotransmissores, entre outros, relacionados aos artrópodes e/ou nematoides e/ou seus hospedeiros. [0001] Process for acting on chemical elements and their combinations, including proteins, DNA, RNA, hormones and neurotransmitters of arthropods and/or nematodes causing and/or transmitting diseases, and/or causing productivity losses, and/ or acting by stimulating the defense of their hosts against these arthropods and/or nematodes, through the transmission of extremely low frequency sequences defined from targets and a set of specific drivers that will act on certain sequences of amino acids and/or nucleotides, among others, of arthropods and/or nematodes and/or their hosts. The desired effect is achieved by strengthening or attenuating the bonds between chemical elements and their combinations, including the constituent elements of nucleotides, amino acids, hormones and neurotransmitters, among others, related to arthropods and/or nematodes and/or their hosts.
ANTERIORIEDADES PREVIOUS
[0002] De forma geral o grau de mutação genética dos artrópodes e/ou nematoides, principal causadora de resistência desses aos produtos químicos, torna bastante complexo e oneroso definir solução para a eliminação ou redução do impacto desses sobre a sanidade humana, animal e vegetal, e produtividade das lavouras. Exis tem atualmente disponíveis dois tipos mais comuns de soluções para controle de artrópode e/ou nematoides: químico e biológico. Ambos têm sido usados, mas podem apresentar efeitos não desejáveis tais como, efeitos colaterais diversos em humanos,
deixar resíduos nos alimentos de origem vegetal e animal (com o potencial de causar doenças em humanos e animais), contaminação de solos, rios, lagos e lençóis freáti- cos, intoxicação de profissionais que aplicam os produtos na lavoura e animais, entre outros. Além disso, podem vir a ter baixa eficiência em face das mutações frequentes dos artrópodes e/ou nematoides e alta pressão de seleção de populações resistentes aos produtos químicos. [0002] In general, the degree of genetic mutation of arthropods and/or nematodes, the main cause of their resistance to chemicals, makes it quite complex and costly to define a solution for eliminating or reducing their impact on human, animal and plant health , and crop productivity. There are currently two most common types of solutions for arthropod and/or nematode control available: chemical and biological. Both have been used, but they can present undesirable effects such as, diverse side effects in humans, leaving residues in food of plant and animal origin (with the potential to cause diseases in humans and animals), contamination of soils, rivers, lakes and groundwater, intoxication of professionals who apply the products to crops and animals, among others. In addition, they may have low efficiency due to frequent mutations of arthropods and/or nematodes and high selection pressure for populations resistant to chemicals.
[0003] A invenção depositada no 30/10/2018, sob número BR102017023442-8 e título "Produto e Processo para Geração de Frequências Extremamente Baixas para Equalização Química" descreve um processo e produto para equalização química, baseia-se na transmissão de frequências que atuarão na equalização de elemen tos químicos ou uma substância, proporcionando, consequentemente, o ajuste de fortalecimento ou atenuação de suas propriedades e características físico-químicas conforme desejado, melhorando a qualidade, aumentando produtividade e eficiência de processos industriais. [0003] The invention filed on 10/30/2018, under number BR102017023442-8 and title "Product and Process for Generating Extremely Low Frequencies for Chemical Equalization" describes a process and product for chemical equalization, based on the transmission of frequencies that will act in the equalization of chemical elements or a substance, providing, consequently, the adjustment of strengthening or attenuation of its properties and physical-chemical characteristics as desired, improving quality, increasing productivity and efficiency of industrial processes.
[0004] Ao fortalecer as propriedades e características físico-químicas de um elemento, possibilita-se a utilização do mesmo em dosagens significativamente menores, sem, contudo, impactar os resultados obtidos. Essa invenção, no entanto, não possui a estrutura de direcionadores, capaz de guiar as sequências de frequências para alvos específicos nem tão pouco a capacidade de atuar sobre organismos biológicos. [0005] A invenção depositada no 30/10/2018, sob número BR102017023442-8 e título "Produto e Processo para Geração de Frequências Extremamente Baixas para Equalização Química" descreve um processo e produto para equalização química, e baseia-se na transmissão de frequências que atuarão na equalização de elementos químicos ou uma substância, proporcionando, consequentemente, o ajuste de fortalec imento ou atenuação de suas propriedades e características físico-químicas conforme desejado, melhorando a qualidade, aumentando produtividade e eficiência de pro cessos industriais. Ao fortalecer as propriedades e características físico-químicas de um elemento, possibilita-se a utilização do mesmo em dosagens significativamente
menores, sem, contudo, impactar os resultados obtidos. Essa invenção, no entanto, não possui a estrutura de direcionadores, capaz de guiar as sequências de frequên cias para alvos específicos nem tão pouco a capacidade de atuar sobre organismos biológicos. [0004] By strengthening the properties and physicochemical characteristics of an element, it is possible to use it in significantly smaller doses, without, however, impacting the results obtained. This invention, however, does not have the structure of drivers, capable of guiding frequency sequences to specific targets, nor the ability to act on biological organisms. [0005] The invention filed on 10/30/2018, under number BR102017023442-8 and title "Product and Process for Generating Extremely Low Frequencies for Chemical Equalization" describes a process and product for chemical equalization, and is based on the transmission of frequencies that will act in the equalization of chemical elements or a substance, providing, consequently, the adjustment of strengthening or attenuation of its properties and physical-chemical characteristics as desired, improving quality, increasing productivity and efficiency of industrial processes. By strengthening the properties and physicochemical characteristics of an element, it is possible to use it in dosages significantly smaller, without, however, impacting the results obtained. This invention, however, does not have the structure of drivers, capable of guiding frequency sequences to specific targets, nor the ability to act on biological organisms.
[0006] A invenção BR 1020190259582 - PRODUTO E PROCESSO PARA ATUAÇÃO EM ORGANISMOS BIOLÓGICOS POR MEIO DE FREQUÊNCIAS EXTREMAMENTE BAIXAS de 07/12/2019 revela um produto e processo de uso de sequências de frequências extremamente baixas para uso em organismos. No entanto a referida invenção não define processos específicos para o uso desse procedimento no caso dos artrópodes e/ou nematoides causadores e/ou transmissores de doenças, e/ou causadores de perdas de produtividade, em seres humanos, animais e vegetais. [0007] A invenção CN211482636 - INSECT EXPELLING CIRCUIT AND WATER PURI- FIER de 21/08/2019 revela um modelo de utilidade referente ao campo de controle de expelição de insetos, e apresenta um circuito de expulsão de insetos e um purificador de água. Um sinal de frequência ultrassónica e um sinal de baixa frequência são respectivamente emitidos para um circuito de acionamento ultrassónico e um circuito de excitação de onda eletromagnética de baixa frequência através de um processador; e o transdutor ultrassónico e o circuito de transmissão são acionados para transmitir ondas ultrassónicas e transmitir ondas eletromagnéticas de baixa frequência, e as ondas ultrassónicas e as ondas eletromagnéticas de baixa frequência podem ser transmitidas simultaneamente ou alternadamente, de modo que os efeitos causados por uma única expulsão ultrassónica contra insetos possam ser efetivamente evitados, consegue-se um efeito contínuo de expulsão de insetos, e a experiência do usuário é melhorada. No entanto a referida invenção não trata da utilização de sequências de Frequências Extremamente Baixas (ELF) na faixa de 0 a 100Hz, e não especifica os alvos moleculares que são atingidos pelas frequências, que podem atuar também colateralmente sobre artrópodes e/ou nematoides benéficos ao ambiente ao qual será aplicado.
[0008] A invenção NZ588814 - METHOD OF INSECT CONTROL de 27/10/2010 revela um método de controle de insetos pela difusão de ondas sonoras de varredura de frequência para causar mau funcionamento do sistema de batida da asa de insetos voadores. O método compreende a determinação da faixa de frequência da asa batidas de insetos, gerando então uma série de ondas sonoras de frequência simples que cobrem toda a faixa de frequência dos batimentos da asa de insetos. As ondas sonoras de frequência única sendo de baixa frequência para alta frequência são ligadas para formar uma série de som ordenada ascendente, descendente e aleatória. As séries de som são também ligadas entre si para formar trilhas sonoras de varredura de frequência que podem ser gravadas digitalmente. A difusão das trilhas sonoras é realizada de tal modo que o SPL (nível de pressão sonora) das ondas sonoras atinja um valor superior a 2,0 Pa (isto é, 100 dB). No entanto a referida invenção não trata da utilização de sequências de Frequências Extremamente Baixas (ELF) na faixa de 0 a 100Hz, e não especifica os alvos moleculares que são atingidos pelas frequências, que podem atuar também colateralmente sobre artrópodes e/ou nematoides benéficos ao ambiente ao qual será aplicado. [0006] The invention BR 1020190259582 - PRODUCT AND PROCESS FOR ACTION IN BIOLOGICAL ORGANISMS THROUGH EXTREMELY LOW FREQUENCIES of 12/07/2019 reveals a product and process for using extremely low frequency sequences for use in organisms. However, said invention does not define specific processes for the use of this procedure in the case of arthropods and/or nematodes that cause and/or transmit diseases, and/or cause productivity losses, in humans, animals and plants. [0007] The invention CN211482636 - INSECT EXPELLING CIRCUIT AND WATER PURIFIER of 08/21/2019 reveals a utility model referring to the field of insect expelling control, and features an insect expulsion circuit and a water purifier. An ultrasonic frequency signal and a low frequency signal are respectively output to an ultrasonic driving circuit and a low frequency electromagnetic wave excitation circuit through a processor; and the ultrasonic transducer and transmission circuit are driven to transmit ultrasonic waves and transmit low frequency electromagnetic waves, and the ultrasonic waves and low frequency electromagnetic waves can be transmitted simultaneously or alternately, so that the effects caused by a single Ultrasonic insect expulsion can be effectively avoided, continuous insect expulsion effect is achieved, and user experience is improved. However, said invention does not deal with the use of Extremely Low Frequency (ELF) sequences in the range of 0 to 100Hz, and does not specify the molecular targets that are reached by the frequencies, which can also act collaterally on beneficial arthropods and/or nematodes when environment to which it will be applied. [0008] The invention NZ588814 - METHOD OF INSECT CONTROL of 10/27/2010 discloses a method of controlling insects by diffusing frequency sweep sound waves to cause malfunction of the wing beating system of flying insects. The method comprises determining the frequency range of insect wing beats, then generating a series of single frequency sound waves that cover the entire frequency range of insect wing beats. Single frequency sound waves being from low frequency to high frequency are linked to form an ascending, descending and random ordered sound series. The sound series are also linked together to form frequency-swept sound tracks that can be recorded digitally. The diffusion of sound tracks is carried out in such a way that the SPL (sound pressure level) of the sound waves reaches a value greater than 2.0 Pa (ie 100 dB). However, said invention does not deal with the use of Extremely Low Frequency (ELF) sequences in the range of 0 to 100Hz, and does not specify the molecular targets that are reached by the frequencies, which can also act collaterally on beneficial arthropods and/or nematodes when environment to which it will be applied.
[0009] A invenção US20060198245 - ELECTRONIC INSECT REPELLING DEVICE de 02/03/2005 revela dispositivo eletrónico pessoal de repulsão de insetos e é um circuito eletrónico suportado no lado inferior de um chapéu de um chapéu que produz um sinal acústico dirigido para o corpo de uma pessoa usando o chapéu. O sinal sónico tem uma frequência que repele insetos, particularmente mosquitos. O sinal sónico é gerado por um circuito oscilador operado por bateria, o qual aciona um trans dutor electroacústico para gerar o sinal acústico. O transdutor acústico é montado com relação ao chapéu de modo que substancialmente todas as áreas expostas da pessoa utilizando o chapéu são irradiadas com energia sónica. O sinal sónico tem essencialmente as mesmas características que o som de um mosquito masculino. No entanto a referida invenção restringe-se a emissão de sinal sonoro com função de repelir insetos e não explora outras vias de ataque como reprodução, motilidade e
outras funções biológicas. [0009] The invention US20060198245 - ELECTRONIC INSECT REPELLING DEVICE of 02/03/2005 discloses a personal electronic device for repelling insects and is an electronic circuit supported on the underside of a hat of a hat that produces an acoustic signal directed towards the body of a person wearing the hat. The sonic signal has a frequency that repels insects, particularly mosquitoes. The sonic signal is generated by a battery-operated oscillator circuit, which drives an electro-acoustic transducer to generate the acoustic signal. The acoustic transducer is mounted relative to the hat so that substantially all exposed areas of the person wearing the hat are radiated with sonic energy. The sonic signal has essentially the same characteristics as the sound of a male mosquito. However, said invention is restricted to the emission of a sound signal with the function of repelling insects and does not explore other ways of attack such as reproduction, motility and other biological functions.
DESCRIÇÃO GERAL GENERAL DESCRIPTION
[0010] Devido às lacunas encontradas no estado da técnica para lidar especificamente com os artrópodes e/ou nematoides dentre eles os causadores e/ou transmissores de doenças, e/ou causadores de perdas de produtividade, fez-se necessário o de senvolvimento de uma nova técnica como revelado a seguir. No caso de artrópode e/ou nematoides, dentre eles os causadores e/ou transmissores de doenças, e/ou causadores de perdas de produtividade, existem três estratégias principais de ataque: [0011] 1 . Atuar sobre sequências específicas de aminoácidos que compõem sítios específicos das proteínas dos artrópodes e/ou nematoides ou hospedeiro. Nesse caso busca-se alterar a função biológica natural das proteínas alvo com o objetivo de estimular o desenvolvimento ou inibir a infecção (infestação e/ou ocorrência) e/ou multiplicação do artrópode e/ou nematoide e/ou modificar os mecanismos de defesa do hospedeiro contra o artrópode e/ou nematoide. [0010] Due to the gaps found in the state of the art to deal specifically with arthropods and/or nematodes, among them the causes and/or transmitters of diseases, and/or causes of productivity losses, it was necessary to develop a new technique as revealed below. In the case of arthropods and/or nematodes, including those that cause and/or transmit diseases, and/or cause loss of productivity, there are three main attack strategies: [0011] 1 . Act on specific sequences of amino acids that make up specific sites of proteins of arthropods and/or nematodes or host. In this case, the aim is to alter the natural biological function of the target proteins with the objective of stimulating the development or inhibiting the infection (infestation and/or occurrence) and/or multiplication of the arthropod and/or nematode and/or modifying the defense mechanisms of the animal. host against the arthropod and/or nematode.
[0012] 2. Atuar sobre sequências de nucleotídeos de forma a impedir ou estimular a expressão gênica de proteínas importantes para processos fisiológicos essenciais para a vida, multiplicação e/ou infecção (infestação e/ou ocorrência) do artrópode e/ou nematoide e/ou modificar os mecanismos de defesa do hospedeiro contra o artrópode e/ou nematoide. [0012] 2. Act on nucleotide sequences in order to prevent or stimulate the gene expression of proteins important for physiological processes essential for life, multiplication and/or infection (infestation and/or occurrence) of the arthropod and/or nematode and/ or modify the host's defense mechanisms against the arthropod and/or nematode.
[0013] 3. Atuar sobre elementos outros componentes dos artrópodes e/ou nematoides, como hormônios, lipídios e neurotransmissores, entre outros a partir dos elementos químicos e/ou compostos químico específicos e ou suas combinações para cada artrópode e/ou nematoide ou grupo de artrópodes ou nematoides, incluindo suas variações e/ou mutações, e/ou de seus hospedeiros, de forma a estimular ou inibir, totalmente ou parcialmente, sua função biológica.Todas essas estratégias de atuação utilizam a mesma técnica aqui utilizada. [0013] 3. Act on elements other components of arthropods and/or nematodes, such as hormones, lipids and neurotransmitters, among others from chemical elements and/or specific chemical compounds and/or their combinations for each arthropod and/or nematode or group of arthropods or nematodes, including their variations and/or mutations, and/or their hosts, in order to stimulate or inhibit, totally or partially, their biological function. All these strategies use the same technique used here.
[0014] O objetivo da técnica aqui demonstrada é inibir ou estimular funções biológicas
ou modificar as propriedades dos elementos, ou compostos químicos, definidos nas estratégias de ataque listadas acima mediante a aplicação de sequências de frequên cias extremamente baixa e conjunto de frequências direcionadoras pré-definidas. [0015] A forma de atuação desenvolvida e revelada nessa técnica é baseada na aplicação da técnica de sequências de frequências extremamente baixas, ou seja, frequências no intervalo aberto entre 0 e 100 Hertz (limites não incluídos). Cada conjunto de sequências de frequências é composto de um ou mais alvos e um ou mais direcionadores específicos para cada espécie de artrópode e/ou nematoide e/ou suas variações e mutações. Isso torna esse conjunto de aplicação específica de artrópode e/ou nematoides e de funções biológicas e/ou fisiológicas escolhidas nos mesmos. Essa invenção revela esses processos de aplicação que são ilustrados nas figuras 2 e 4. Cada combinação de alvo e direcionador é concebida para definir uma solução matematicamente única. [0014] The purpose of the technique demonstrated here is to inhibit or stimulate biological functions or modify the properties of the elements, or chemical compounds, defined in the attack strategies listed above by applying extremely low frequency sequences and a set of predefined driving frequencies. [0015] The way of acting developed and revealed in this technique is based on the application of the technique of extremely low frequency sequences, that is, frequencies in the open range between 0 and 100 Hertz (limits not included). Each set of frequency sequences is composed of one or more targets and one or more specific drivers for each arthropod and/or nematode species and/or its variations and mutations. This makes this set of specific application of arthropods and/or nematodes and of biological and/or physiological functions chosen in them. This invention discloses those application processes which are illustrated in Figures 2 and 4. Each target and driver combination is designed to define a mathematically unique solution.
[0016] No caso 1 , acima, essa invenção faz uso de uma ou mais sequências de frequências previamente determinadas (cada uma com alvo e direcionador determi nando solução única) e validadas em laboratório, para gerar a diminuição ou aumento da distância interatômica dos elementos químicos que formam os aminoácidos alvo, alterando a conformação da proteína em questão e consequentemente sua função biológica. [0016] In case 1, above, this invention makes use of one or more sequences of previously determined frequencies (each with target and driver determining a unique solution) and validated in the laboratory, to generate the decrease or increase of the interatomic distance of the elements chemicals that form the target amino acids, altering the conformation of the protein in question and consequently its biological function.
[0017] No caso 2, acima, essa invenção faz uso de uma ou mais sequências de frequências previamente determinadas (cada uma com alvo e direcionador determi nando solução única) e validadas em laboratório, para gerar a diminuição ou aumento da distância interatômica dos elementos químicos que formam os nucleotídeos alvo, alterando a conformação destes nucleotídeos e consequentemente sua função biológ ica. [0017] In case 2, above, this invention makes use of one or more sequences of frequencies previously determined (each with target and driver determining a unique solution) and validated in the laboratory, to generate the decrease or increase of the interatomic distance of the elements chemicals that form the target nucleotides, altering the conformation of these nucleotides and consequently their biological function.
[0018] No caso 3, acima, essa invenção faz uso de uma ou mais sequências de fre quências previamente determinadas (cada uma com alvo e direcionador determinando solução única) e validadas em laboratório, para gerar a diminuição ou aumento da
distância interatômica dos elementos químicos e/ou compostos químicos (tais como hormônios, lipídios e neurotransmissores, entre outros) alvo, alterando a conformação desses e consequentemente suas propriedades e/ou funções biológicas. [0018] In case 3, above, this invention makes use of one or more sequences of previously determined frequencies (each with target and driver determining a unique solution) and validated in the laboratory, to generate the decrease or increase of the interatomic distance of the target chemical elements and/or chemical compounds (such as hormones, lipids and neurotransmitters, among others), altering their conformation and consequently their biological properties and/or functions.
[0019] As três estratégias descritas acima podem ser usadas individualmente e/ou concomitantemente numa mesma implementação da técnica aqui revelada. [0019] The three strategies described above can be used individually and/or concurrently in the same implementation of the technique disclosed herein.
MODALIDADES PREFERIDAS PREFERRED MODALITIES
[0020] Uma primeira modalidade preferida trata da aplicação da estratégia 1 (atuação sobre aminoácidos) que tem como alvo as sequências de aminoácidos da enzima Acetilcolinesterase (AChE) dos artrópodes e/ou nematoides. Nesse caso as sequên cias de frequências atuarão conforme suas frequências direcionadoras sobre as sequências de aminoácidos que formam as diferentes possibilidades de sítio ativo (sí tio de ligação) da enzima Acetilcolinesterase (AChE) dos artrópodes e/ou nematoides. Como consequência dessa atuação, ficará impedida ou dificultada a ação da enzima Acetilcolinesterase (AChE) dos artrópodes e/ou nematoides, causando hiperexcitação nas sinapses nervosas devido a grande quantidade do neurotransmissor acetilcolina, danificando a transmissão nervosa dos artrópodes e/ou nematoides. [0020] A first preferred embodiment deals with the application of strategy 1 (acting on amino acids) that targets the amino acid sequences of the Acetylcholinesterase (AChE) enzyme of arthropods and/or nematodes. In this case, the frequency sequences will act according to their driving frequencies on the amino acid sequences that form the different possibilities of active site (binding site) of the Acetylcholinesterase (AChE) enzyme of arthropods and/or nematodes. As a result of this action, the action of the Acetylcholinesterase (AChE) enzyme of arthropods and/or nematodes will be prevented or hindered, causing hyperexcitation in nerve synapses due to the large amount of the neurotransmitter acetylcholine, damaging the nerve transmission of arthropods and/or nematodes.
[0021] Uma segunda modalidade preferida trata da aplicação da estratégia 1 (atuação sobre aminoácidos) que tem como alvo as sequências de aminoácidos do canal de cloreto ativado por GABA (Ácido gama-aminobutírico) dos artrópodes e/ou nema toides. Nesse caso as sequências de frequências atuarão conforme suas frequências direcionadoras sobre as sequências de aminoácidos que formam as diferentes pos sibilidades de sítio ativo (sítio de ligação) do GABA (Ácido gama-aminobutírico) ao canal de cloreto dos artrópodes e/ou nematoides. Como consequência dessa atuação, ficará impedida ou dificultada a ligação do GABA aos canais de cloreto dos artrópodes e/ou nematoides, causando hiperexcitação nas sinapses nervosas, danificando a transmissão nervosa dos artrópodes e/ou nematoides. [0021] A second preferred modality deals with the application of strategy 1 (acting on amino acids) that targets the amino acid sequences of the chloride channel activated by GABA (Gamma-aminobutyric acid) of arthropods and/or nematodes. In this case, the frequency sequences will act according to their driving frequencies on the amino acid sequences that form the different possibilities of active site (binding site) of GABA (gamma-aminobutyric acid) to the chloride channel of arthropods and/or nematodes. As a consequence of this action, the binding of GABA to the chloride channels of arthropods and/or nematodes will be prevented or difficult, causing hyperexcitation in nerve synapses, damaging the nervous transmission of arthropods and/or nematodes.
[0022] Uma terceira modalidade preferida trata da aplicação da estratégia 1 (atuação
sobre aminoácidos) que tem como alvo as sequências de aminoácidos dos canais de sódio dos artrópodes e/ou nematoides. Nesse caso as sequências de frequências atuarão conforme suas frequências direcionadoras sobre as sequências de aminoá cidos que formam as diferentes possibilidades de sítio ativo (sítio de ligação) dos neurotransmissores reguladores aos canais de sódio dos artrópodes e/ou nematoides. Como consequência dessa atuação, ficará impedida ou dificultada a ligação dos neurotransmissores reguladores dos canais de sódio dos artrópodes e/ou nematoides, causando hiperexcitação e/ou bloqueio nas sinapses nervosas, danificando a trans missão nervosa dos artrópodes e/ou nematoides. [0022] A third preferred modality deals with the application of strategy 1 (acting on amino acids) that target the amino acid sequences of the sodium channels of arthropods and/or nematodes. In this case, the frequency sequences will act according to their driving frequencies on the amino acid sequences that form the different possibilities of active site (binding site) of the regulatory neurotransmitters to the sodium channels of arthropods and/or nematodes. As a consequence of this action, the binding of neurotransmitters regulating the sodium channels of arthropods and/or nematodes will be prevented or hindered, causing hyperexcitation and/or blockage in nerve synapses, damaging the nerve transmission of arthropods and/or nematodes.
[0023] Uma quarta modalidade preferida trata da aplicação da estratégia 1 (atuação sobre aminoácidos) que tem como alvo as sequências de aminoácidos da enzima ATP Sintase dos artrópodes e/ou nematoides. Nesse caso as sequências de frequências atuarão conforme suas frequências direcionadoras sobre as sequências de aminoáci dos que formam as diferentes possibilidades de sítio ativo (sítio de ligação) da enzima ATP Sintase dos artrópodes e/ou nematoides. Como consequência dessa atuação, ficará impedida ou dificultada a ação da enzima ATP Sintase dos artrópodes e/ou nematoides, causando inibição da síntese de ATP nas mitocôndrias, danificando a transmissão nervosa dos artrópodes e/ou nematoides. [0023] A fourth preferred modality deals with the application of strategy 1 (acting on amino acids) that targets the amino acid sequences of the ATP synthase enzyme of arthropods and/or nematodes. In this case, the frequency sequences will act according to their driving frequencies on the amino acid sequences that form the different possibilities of active site (binding site) of the ATP synthase enzyme of arthropods and/or nematodes. As a consequence of this action, the action of the ATP synthase enzyme of arthropods and/or nematodes will be prevented or hindered, causing inhibition of ATP synthesis in mitochondria, damaging the nerve transmission of arthropods and/or nematodes.
[0024] Uma quinta modalidade preferida trata da aplicação da estratégia 1 (atuação sobre aminoácido) que tem como alvo as sequências de aminoácidos da enzima Acetil CoA Carboxilase dos artrópodes e/ou nematoides. Nesse caso as sequências de frequências atuarão conforme suas frequências direcionadoras sobre as sequên cias de aminoácidos que formam as diferentes possibilidades de sítio ativo (sítio de ligação) da enzima Acetil CoA Carboxilase dos artrópodes e/ou nematoides. Como consequência dessa atuação, ficará impedida ou dificultada a ação da enzima Acetil CoA Carboxilase dos artrópodes e/ou nematoides, causando inibição da primeira etapa da biossíntese de lipídios, danificando a síntese de lipídios dos artrópodes e/ou nematoides.
[0025] Uma sexta modalidade preferida trata da aplicação da estratégia 2 (atuação sobre nucleotídeos) que tem como alvo a sequência de nucleotídeos (Figura 3) que participam do metabolismo dos ácidos nucleicos dos artrópodes e/ou nematoides. Nesse caso as sequências de frequências atuarão conforme suas frequências dire- cionadoras sobre as sequências de nucleotídeos impedindo a tradução (Figura 4) da região codificante de proteínas que participam do metabolismo dos ácidos nucleicos dos artrópodes e/ou nematoides. [0024] A fifth preferred embodiment deals with the application of strategy 1 (acting on amino acid) which targets the amino acid sequences of the Acetyl CoA Carboxylase enzyme of arthropods and/or nematodes. In this case, the frequency sequences will act according to their driving frequencies on the amino acid sequences that form the different possibilities of active site (binding site) of the Acetyl CoA Carboxylase enzyme of arthropods and/or nematodes. As a consequence of this action, the action of the Acetyl CoA Carboxylase enzyme of arthropods and/or nematodes will be prevented or hindered, causing inhibition of the first stage of lipid biosynthesis, damaging the synthesis of lipids in arthropods and/or nematodes. [0025] A sixth preferred modality deals with the application of strategy 2 (action on nucleotides) that targets the sequence of nucleotides (Figure 3) that participate in the metabolism of nucleic acids of arthropods and/or nematodes. In this case, the frequency sequences will act according to their driving frequencies on the nucleotide sequences, preventing the translation (Figure 4) of the coding region of proteins that participate in the metabolism of nucleic acids of arthropods and/or nematodes.
[0026] Uma sétima modalidade preferida trata da aplicação da estratégia 3 (atuar sobre elementos químicos e/ou compostos químicos, tais como hormônios, lipídios e neurotransmissores, entre outros) que tem como alvo o hormônio juvenil (Figura 5) dos artrópodes e/ou nematoides. Nesse caso as sequências de frequências atu arão conforme suas frequências direcionadoras sobre as sequências químicas que formam o hormônio juvenil dos artrópodes e/ou nematoides. Como consequência dessa atuação, ficará estimulada ou impedida a ação do hormônio juvenil (Figura 6) dos artrópodes e/ou nematoides, causando inibição ou estimulação da metamorfose, danificando o processo de metamorfose dos artrópodes e/ou nematoides quando aplicadas na fase correta de seu ciclo de vida. [0026] A seventh preferred modality deals with the application of strategy 3 (acting on chemical elements and/or chemical compounds, such as hormones, lipids and neurotransmitters, among others) that targets the juvenile hormone (Figure 5) of arthropods and/or arthropods. or nematodes. In this case, the frequency sequences will act according to their driving frequencies on the chemical sequences that form the juvenile hormone of arthropods and/or nematodes. As a consequence of this action, the action of the juvenile hormone (Figure 6) of arthropods and/or nematodes will be stimulated or prevented, causing inhibition or stimulation of metamorphosis, damaging the process of metamorphosis of arthropods and/or nematodes when applied at the correct stage of their growth. life cycle.
[0027] Uma oitava modalidade preferida trata da aplicação da estratégia 1 (atuação sobre aminoácidos) que tem como alvo as sequências de aminoácidos do canal de cloreto bloqueado por Glutamato dos artrópodes e/ou nematoides (Figura 1). Nesse caso as sequências de frequências atuarão conforme suas frequências direcionadoras sobre as sequências de aminoácidos que formam as diferentes possibilidades de sítio ativo (sítio de ligação) do Glutamato ao canal de cloreto dos artrópodes e/ou nematoides. Como consequência dessa atuação, ficará impedida ou dificultada a ligação do Glutamato aos canais de cloreto (Figura 2) dos artrópodes e/ou nematoides, causando paralisia das sinapses nervosas, danificando a transmissão nervosa dos artrópodes e/ou nematoides. [0027] An eighth preferred embodiment deals with the application of strategy 1 (acting on amino acids) that targets the amino acid sequences of the chloride channel blocked by Glutamate of arthropods and/or nematodes (Figure 1). In this case, the frequency sequences will act according to their driving frequencies on the amino acid sequences that form the different possibilities of active site (binding site) of Glutamate to the chloride channel of arthropods and/or nematodes. As a consequence of this action, the binding of Glutamate to the chloride channels (Figure 2) of arthropods and/or nematodes will be prevented or difficult, causing paralysis of nerve synapses, damaging the nerve transmission of arthropods and/or nematodes.
[0028] Uma nona modalidade preferida trata da aplicação da estratégia 3 (atuar sobre
elementos químicos e/ou compostos químicos, tais como hormônios, lipídios e neuro- transmissores, entre outros) que tem como alvo o hormônio ecdisona dos artrópodes e/ou nematoides. Nesse caso as sequências de frequências atuarão conforme suas frequências direcionadoras sobre as sequências químicas que formam o hormônio ecdisona dos artrópodes e/ou nematoides. Como consequência dessa atuação, ficará estimulada ou impedida a ação do hormônio ecdisona dos artrópodes e/ou nema toides, causando inibição ou estimulação da muda, danificando o processo de ecdise dos artrópodes e/ou nematoides quando aplicadas na fase correta de seu ciclo de vida. [0028] A ninth preferred modality deals with the application of strategy 3 (acting on chemical elements and/or chemical compounds, such as hormones, lipids and neurotransmitters, among others) that target the ecdysone hormone of arthropods and/or nematodes. In this case, the frequency sequences will act according to their driving frequencies on the chemical sequences that form the ecdysone hormone of arthropods and/or nematodes. As a result of this action, the action of the ecdysone hormone of arthropods and/or nematodes will be stimulated or prevented, causing inhibition or stimulation of the molt, damaging the process of ecdysis of arthropods and/or nematodes when applied at the correct stage of their life cycle. .
[0029] Uma décima modalidade preferida trata da aplicação da estratégia 1 (atuação sobre aminoácidos) que tem como alvo as sequências de aminoácidos, toda ou em parte, que compõe as proteínas do complexo da respiração celular. Nesse caso as sequências de frequências atuarão conforme suas frequências direcionadoras sobre as sequências de aminoácidos que formam o sítio ativo (sítio de ligação) das proteínas citadas anteriormente. Como consequência dessa atuação, ficará inibida, impedida ou dificultada, totalmente ou parcialmente, a respiração celular dos artrópodes e/ou nematoides. [0029] A tenth preferred embodiment deals with the application of strategy 1 (acting on amino acids) that targets the amino acid sequences, in whole or in part, that make up the proteins of the cellular respiration complex. In this case, the frequency sequences will act according to their driving frequencies on the amino acid sequences that form the active site (binding site) of the proteins mentioned above. As a consequence of this action, the cellular respiration of arthropods and/or nematodes will be inhibited, impeded or hampered, totally or partially.
[0030] Uma décima primeira modalidade preferida trata da aplicação da estratégia 1 (atuação sobre aminoácidos) que tem como alvo as sequências de aminoácidos, toda ou em parte, que compõe as proteínas que atuam na síntese de aminoácidos e proteí nas. Nesse caso as sequências de frequências atuarão conforme suas frequências direcionadoras sobre as sequências de aminoácidos que formam o sítio ativo (sítio de ligação) das proteínas que atuam na síntese de aminoácidos e proteínas do artrópode e/ou nematoide. Como consequência dessa atuação, ficará impedida ou dificultada a síntese de aminoácidos e proteínas dos artrópodes e/ou nematoides.
[0030] An eleventh preferred embodiment deals with the application of strategy 1 (acting on amino acids) that targets the amino acid sequences, in whole or in part, that make up the proteins that act in the synthesis of amino acids and proteins. In this case, the frequency sequences will act according to their driving frequencies on the amino acid sequences that form the active site (binding site) of the proteins that act in the synthesis of amino acids and proteins of the arthropod and/or nematode. As a consequence of this action, the synthesis of amino acids and proteins of arthropods and/or nematodes will be prevented or hindered.
Claims
1 . Processo para atuação em artrópodes e/ou nematoides por meio de sequências de frequências extremamente baixas e frequências direcionadoras caracterizado por fazer uso de sequências de frequências que são únicas para cada alvo determinado pelas frequências direcionadoras em um ou mais artrópodes e/ou nematoides (in cluindo suas variações e/ou mutações) e/ou seus organismos hospedeiros, para atuar sobre sequências de aminoácidos específicas estimulando ou inibindo, totalmente ou parcialmente, sua função biológica. 1 . Process for acting on arthropods and/or nematodes through sequences of extremely low frequencies and driving frequencies characterized by making use of frequency sequences that are unique for each target determined by the driving frequencies in one or more arthropods and/or nematodes (including their variations and/or mutations) and/or their host organisms, to act on specific amino acid sequences stimulating or inhibiting, totally or partially, their biological function.
2. Processo conforme reivindicação 1 caracterizado por ter como alvo as sequências de aminoácidos, toda ou em parte, que compõem as proteínas do complexo da respiração celular, estimulando ou inibindo, totalmente ou parcialmente, a respiração celular dos artrópodes e/ou nematoides. Process according to claim 1, characterized in that it targets the amino acid sequences, in whole or in part, that make up the proteins of the cellular respiration complex, stimulating or inhibiting, totally or partially, the cellular respiration of arthropods and/or nematodes.
3. Processo conforme reivindicação 1 caracterizado por ter como alvo as sequências de aminoácidos, toda ou em parte, que compõem as proteínas do complexo do sistema nervoso e/ou muscular, estimulando ou inibindo, totalmente ou parcialmente, a transmissão nervosa e movimentação dos artrópodes e/ou nematoides. Process according to claim 1, characterized by targeting the amino acid sequences, in whole or in part, that make up the proteins of the nervous and/or muscular system complex, stimulating or inhibiting, totally or partially, the nervous transmission and movement of arthropods and/or nematodes.
4. Processo conforme reivindicação 1 caracterizado por ter como alvo as sequências de aminoácidos, toda ou em parte, que compõem as proteínas que atuam na síntese de aminoácidos e proteínas, estimulando ou inibindo, totalmente ou parcialmente, a síntese de aminoácidos e proteínas dos artrópodes e/ou nematoides. Process according to claim 1, characterized by targeting the amino acid sequences, in whole or in part, that make up the proteins that act in the synthesis of amino acids and proteins, stimulating or inhibiting, totally or partially, the synthesis of amino acids and proteins of arthropods and/or nematodes.
5. Processo para atuação em artrópodes e/ou nematoides por meio de sequências de frequências extremamente baixas e frequências direcionadoras caracterizado por fazer uso de sequências de frequências que são únicas para cada alvo determinado pelas frequências direcionadoras em um ou mais artrópodes e/ou nematoides (in cluindo suas variações e/ou mutações) e/ou seus organismos hospedeiros, para atuar sobre sequências de nucleotídeos específicas estimulando ou inibindo, totalmente ou parcialmente, sua função biológica. 5. Process for acting on arthropods and/or nematodes through sequences of extremely low frequencies and driving frequencies characterized by making use of frequency sequences that are unique for each target determined by the driving frequencies in one or more arthropods and/or nematodes ( including variations and/or mutations thereof) and/or their host organisms, to act on specific nucleotide sequences, stimulating or inhibiting, totally or partially, their biological function.
6. Processo conforme reivindicação 5 caracterizado por ter como alvo as sequências
2\2 de nucleotídeos, toda ou em parte, que podem ou não ser transcritas e/ou traduzidas em proteínas que atuam em funções vitais aos artrópodes e/ou nematoides, estimu lando ou inibindo, totalmente ou parcialmente, a síntese de aminoácidos, peptídeos e proteínas dos artrópodes e/ou nematoides. Process according to claim 5, characterized in that it targets the sequences 2\2 of nucleotides, in whole or in part, which may or may not be transcribed and/or translated into proteins that act in vital functions for arthropods and/or nematodes, stimulating or inhibiting, totally or partially, the synthesis of amino acids, peptides and proteins from arthropods and/or nematodes.
7. Processo conforme reivindicação 5 caracterizado por ter como alvo as sequências de nucleotídeos, toda ou em parte, que podem ou não ser transcritas e/ou traduzidas em proteínas que atuam na indução de defesa dos hospedeiros, melhorando a indução dos seus mecanismos de defesa contra artrópodes e/ou nematoides causadores de doenças. 7. Process according to claim 5 characterized by targeting nucleotide sequences, in whole or in part, that may or may not be transcribed and/or translated into proteins that act in the induction of host defense, improving the induction of their defense mechanisms against disease-causing arthropods and/or nematodes.
8. Processo para atuação em artrópodes e/ou nematoides por meio de sequências de frequências extremamente baixas e frequências direcionadoras caracterizado por fazer uso de sequências de frequências que são únicas para cada alvo determinado pelas frequências direcionadoras em um ou mais artrópodes e/ou nematoides (in cluindo suas variações e/ou mutações) e/ou seus organismos hospedeiros, para atuar sobre elementos químicos e/ou compostos químicos, tais como hormônios, lipídios e neurotransmissores, entre outros, estimulando ou inibindo, totalmente ou parcialmente, sua função biológica. 8. Process for acting on arthropods and/or nematodes through sequences of extremely low frequencies and driving frequencies characterized by making use of frequency sequences that are unique for each target determined by the driving frequencies in one or more arthropods and/or nematodes ( including their variations and/or mutations) and/or their host organisms, to act on chemical elements and/or chemical compounds, such as hormones, lipids and neurotransmitters, among others, stimulating or inhibiting, totally or partially, their biological function.
9. Processo conforme reivindicação 8 caracterizado por ter como alvo elementos químicos e/ou compostos químicos, todo ou em parte, que compõem os hormônios que atuam em processos de crescimento e desenvolvimento dos artrópodes, tais como o hormônio juvenil e a ecdisona, estimulando ou inibindo, totalmente ou parcialmente, a ação do hormônio juvenil e/ou a ecdisona dos artrópodes e/ou nematoides.
9. Process according to claim 8, characterized by targeting chemical elements and/or chemical compounds, in whole or in part, that make up the hormones that act in the growth and development processes of arthropods, such as juvenile hormone and ecdysone, stimulating or inhibiting, totally or partially, the action of juvenile hormone and/or ecdysone of arthropods and/or nematodes.
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| BRBR1020210064366 | 2021-04-03 | ||
| BR102021006436-6A BR102021006436A2 (en) | 2021-04-03 | 2021-04-03 | PROCESS FOR WORKING ON ARTHROPODS AND/OR NEMATOIDS THROUGH EXTREMELY LOW FREQUENCY SEQUENCES AND DRIVING FREQUENCIES |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5424551A (en) * | 1993-09-15 | 1995-06-13 | Richard J. Fox | Frequency emitter for control of insects |
| US20060198245A1 (en) | 2005-03-02 | 2006-09-07 | Cheung William S | Electronic insect repelling device |
| NZ588814A (en) | 2009-10-28 | 2012-02-24 | Jinan Cao | Method of insect control using stepped frequency sweeps to resonate with the structure of an insects wing |
| TW201517792A (en) * | 2013-11-15 | 2015-05-16 | Jiong-Di Chen | Infrasound insecticidal device |
| KR20170090605A (en) * | 2016-01-29 | 2017-08-08 | 유상철 | A pest control decice |
| CN211482636U (en) | 2019-08-21 | 2020-09-15 | 佛山市顺德区美的饮水机制造有限公司 | Insect repelling circuit and water purifier |
| CN112586471A (en) * | 2020-12-15 | 2021-04-02 | 龙海市思博工业设计有限公司 | Deinsectization method and deinsectization device |
-
2021
- 2021-04-03 BR BR102021006436-6A patent/BR102021006436A2/en unknown
-
2022
- 2022-03-30 AU AU2022251148A patent/AU2022251148A1/en active Pending
- 2022-03-30 WO PCT/BR2022/050111 patent/WO2022204772A1/en active Application Filing
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5424551A (en) * | 1993-09-15 | 1995-06-13 | Richard J. Fox | Frequency emitter for control of insects |
| US20060198245A1 (en) | 2005-03-02 | 2006-09-07 | Cheung William S | Electronic insect repelling device |
| NZ588814A (en) | 2009-10-28 | 2012-02-24 | Jinan Cao | Method of insect control using stepped frequency sweeps to resonate with the structure of an insects wing |
| TW201517792A (en) * | 2013-11-15 | 2015-05-16 | Jiong-Di Chen | Infrasound insecticidal device |
| KR20170090605A (en) * | 2016-01-29 | 2017-08-08 | 유상철 | A pest control decice |
| CN211482636U (en) | 2019-08-21 | 2020-09-15 | 佛山市顺德区美的饮水机制造有限公司 | Insect repelling circuit and water purifier |
| CN112586471A (en) * | 2020-12-15 | 2021-04-02 | 龙海市思博工业设计有限公司 | Deinsectization method and deinsectization device |
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| BR102021006436A2 (en) | 2022-10-04 |
| AU2022251148A1 (en) | 2023-10-19 |
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