WO2022200327A3 - Verwendung von d-enantiomeren peptidliganden von monomerem a-synuclein für die therapie verschiedener synucleinopathien - Google Patents
Verwendung von d-enantiomeren peptidliganden von monomerem a-synuclein für die therapie verschiedener synucleinopathien Download PDFInfo
- Publication number
- WO2022200327A3 WO2022200327A3 PCT/EP2022/057456 EP2022057456W WO2022200327A3 WO 2022200327 A3 WO2022200327 A3 WO 2022200327A3 EP 2022057456 W EP2022057456 W EP 2022057456W WO 2022200327 A3 WO2022200327 A3 WO 2022200327A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- synuclein
- monomeric
- therapy
- peptide ligands
- seq
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 208000032859 Synucleinopathies Diseases 0.000 title abstract 2
- 102000003802 alpha-Synuclein Human genes 0.000 title 1
- 108090000185 alpha-Synuclein Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Psychiatry (AREA)
- Molecular Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Beschrieben wird ein Peptid, umfassend eine Aminosäuresequenz ausgewählt aus der Gruppe bestehend aus SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5 SEQ ID NO: 6 oder SEQ ID NO: 7 sowie ein solches Peptid zur Verwendung in der Behandlung von Synucleinopathien.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2022241923A AU2022241923A1 (en) | 2021-03-22 | 2022-03-22 | USE OF D-ENANTIOMERIC PEPTIDE LIGANDS OF MONOMERIC α-SYNUCLEIN FOR THE THERAPY OF VARIOUS SYNUCLEINOPATHIES |
| KR1020237036171A KR20230159873A (ko) | 2021-03-22 | 2022-03-22 | 다양한 시누클레인병증의 치료를 위한 단량체 α-시누클레인의 D-거울상이성질체 펩타이드 리간드의 용도 |
| JP2023558629A JP2024510826A (ja) | 2021-03-22 | 2022-03-22 | 様々なシヌクレイン病の治療のためのモノマーα－シヌクレインのＤ－エナンチオマーペプチドリガンドの使用 |
| CA3213262A CA3213262A1 (en) | 2021-03-22 | 2022-03-22 | Use of d-enantiomeric peptide ligands of monomeric a-synuclein for the therapy of various synucleinopathies |
| EP22718591.5A EP4313107A2 (de) | 2021-03-22 | 2022-03-22 | Verwendung von d-enantiomeren peptidliganden von monomerem alpha-synuclein für die therapie verschiedener synucleinopathien |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102021107061.9A DE102021107061A1 (de) | 2021-03-22 | 2021-03-22 | Verwendung von d-enantiomeren peptidliganden von monomerem a-synuclein für die therapie verschiedener synucleinopathien |
| DE102021107061.9 | 2021-03-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2022200327A2 WO2022200327A2 (de) | 2022-09-29 |
| WO2022200327A3 true WO2022200327A3 (de) | 2022-11-17 |
Family
ID=81386854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2022/057456 WO2022200327A2 (de) | 2021-03-22 | 2022-03-22 | Verwendung von d-enantiomeren peptidliganden von monomerem a-synuclein für die therapie verschiedener synucleinopathien |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP4313107A2 (de) |
| JP (1) | JP2024510826A (de) |
| KR (1) | KR20230159873A (de) |
| AU (1) | AU2022241923A1 (de) |
| CA (1) | CA3213262A1 (de) |
| DE (1) | DE102021107061A1 (de) |
| WO (1) | WO2022200327A2 (de) |
-
2021
- 2021-03-22 DE DE102021107061.9A patent/DE102021107061A1/de active Pending
-
2022
- 2022-03-22 WO PCT/EP2022/057456 patent/WO2022200327A2/de active Application Filing
- 2022-03-22 KR KR1020237036171A patent/KR20230159873A/ko active Search and Examination
- 2022-03-22 CA CA3213262A patent/CA3213262A1/en active Pending
- 2022-03-22 EP EP22718591.5A patent/EP4313107A2/de active Pending
- 2022-03-22 AU AU2022241923A patent/AU2022241923A1/en active Pending
- 2022-03-22 JP JP2023558629A patent/JP2024510826A/ja active Pending
Non-Patent Citations (2)
| Title |
|---|
| RONIT SHALTIEL-KARYO ET AL: "Inhibiting α-Synuclein Oligomerization by Stable Cell-Penetrating β-Synuclein Fragments Recovers Phenotype of Parkinson's Disease Model Flies", PLOS ONE, vol. 5, no. 11, 10 November 2010 (2010-11-10), pages e13863, XP055243084, DOI: 10.1371/journal.pone.0013863 * |
| WILLBOLD D ET AL: "1076: Identification and characterization of anti-prionic compounds that disassemble ?Syn prions as a novel therapeutic approach for synucleinopathies", vol. 35, no. SUPPL 1, 1 September 2020 (2020-09-01), pages S489, XP009536370, ISSN: 1531-8257, Retrieved from the Internet <URL:https://www.mdsabstracts.org/abstract/identification-and-characterization-of-anti-prionic-compounds-that-disassemble-%CE%B1syn-prions-as-a-novel-therapeutic-approach-for-synucleinopathies/> * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4313107A2 (de) | 2024-02-07 |
| WO2022200327A2 (de) | 2022-09-29 |
| KR20230159873A (ko) | 2023-11-22 |
| JP2024510826A (ja) | 2024-03-11 |
| CA3213262A1 (en) | 2022-09-29 |
| DE102021107061A1 (de) | 2022-09-22 |
| AU2022241923A9 (en) | 2024-02-22 |
| AU2022241923A1 (en) | 2023-10-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX348464B (es) | Agente inductor de inmunidad. | |
| NZ604818A (en) | Variants of activin iib receptor polypeptides and uses thereof | |
| DE602005020165D1 (de) | Verfahren zur herstellung von l-arginin, l-ornithin oder l-citrullin | |
| IN2014CN02050A (de) | ||
| MX2019015502A (es) | L-asparaginasa modificada. | |
| UA111141C2 (uk) | Рекомбінантні антигени рсв | |
| MX340014B (es) | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. | |
| MX340015B (es) | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. | |
| MX342291B (es) | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. | |
| MX340016B (es) | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. | |
| AU2003264419A1 (en) | Kdr peptides and vaccines containing the same | |
| NZ708990A (en) | Method for activating helper t cell | |
| NZ602845A (en) | Inhibiting peptides derived from trem-like transcript 1 (tlt-1) and uses thereof | |
| WO2002061076A1 (en) | Adiponectin-associated protein | |
| CY1109631T1 (el) | Χρησιμοποιηση πεπτιδιων, τα οποια εχουν παραχθει απο την αα- ή ββ-αλυσιδα του ανθρωπινου ινωδογονου, για τη θεραπεια σοκ | |
| MX2021001507A (es) | Farmaco de diagnostico y metodo de diagnostico para la enfermedad de alzheimer. | |
| HK1121383A1 (en) | Wound healing agent and composition | |
| WO2022200327A3 (de) | Verwendung von d-enantiomeren peptidliganden von monomerem a-synuclein für die therapie verschiedener synucleinopathien | |
| MX2021010552A (es) | Nuevo peptido y uso del mismo. | |
| EP1842911A4 (de) | Hla bindende peptide, für diese codierende dna-fragmente und rekombinante vektoren | |
| ATE551353T1 (de) | Protein mit fusogener wirkung, nukleinsäuresequenzen, die für dieses protein codieren und pharmazeutische zusammensetzungen, die dieses enthalten | |
| MX2020010422A (es) | Alfa-amilasa maltogenica variante. | |
| WO2019059572A3 (ko) | 홍어 껍질 유래의 신규한 항균 펩타이드 및 이의 용도 | |
| WO2007066018A3 (fr) | Peptides qui peuvent se lier a la proteine nef et leurs applications pharmaceutiques | |
| EA202090802A1 (ru) | Пептидная композиция для лечения повреждений, связанных с возбуждающей нейротоксичностью |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 22718591 Country of ref document: EP Kind code of ref document: A2 |
|
| WWE | Wipo information: entry into national phase |
Ref document number: 2023558629 Country of ref document: JP |
|
| WWE | Wipo information: entry into national phase |
Ref document number: 2022241923 Country of ref document: AU Ref document number: AU2022241923 Country of ref document: AU Ref document number: 3213262 Country of ref document: CA |
|
| ENP | Entry into the national phase |
Ref document number: 2022241923 Country of ref document: AU Date of ref document: 20220322 Kind code of ref document: A |
|
| ENP | Entry into the national phase |
Ref document number: 20237036171 Country of ref document: KR Kind code of ref document: A |
|
| WWE | Wipo information: entry into national phase |
Ref document number: 1020237036171 Country of ref document: KR |
|
| WWE | Wipo information: entry into national phase |
Ref document number: 2022718591 Country of ref document: EP |
|
| ENP | Entry into the national phase |
Ref document number: 2022718591 Country of ref document: EP Effective date: 20231023 |