WO2022173246A3 - Composition for preventing or treating novel coronavirus infection, comprising psidiuma guajava extract, pheophytin fraction thereof, or meroterpenoid-based compound isolated therefrom as active ingredient - Google Patents

Composition for preventing or treating novel coronavirus infection, comprising psidiuma guajava extract, pheophytin fraction thereof, or meroterpenoid-based compound isolated therefrom as active ingredient Download PDF

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Publication number
WO2022173246A3
WO2022173246A3 PCT/KR2022/002045 KR2022002045W WO2022173246A3 WO 2022173246 A3 WO2022173246 A3 WO 2022173246A3 KR 2022002045 W KR2022002045 W KR 2022002045W WO 2022173246 A3 WO2022173246 A3 WO 2022173246A3
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WO
WIPO (PCT)
Prior art keywords
meroterpenoid
composition
based compound
novel coronavirus
psidiuma
Prior art date
Application number
PCT/KR2022/002045
Other languages
French (fr)
Korean (ko)
Other versions
WO2022173246A2 (en
Inventor
오원근
류별
마이반휴
박은진
최영기
김은하
김세미
Original Assignee
서울대학교산학협력단
충북대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 서울대학교산학협력단, 충북대학교 산학협력단 filed Critical 서울대학교산학협력단
Publication of WO2022173246A2 publication Critical patent/WO2022173246A2/en
Publication of WO2022173246A3 publication Critical patent/WO2022173246A3/en

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A01N65/28—Myrtaceae [Myrtle family], e.g. teatree or clove
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/121—Heterocyclic compounds containing oxygen or sulfur as hetero atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/324—Foods, ingredients or supplements having a functional effect on health having an effect on the immune system
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/30—Other Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Polymers & Plastics (AREA)
  • Botany (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Husbandry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physiology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Medical Informatics (AREA)
  • Nutrition Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a composition for preventing or treating novel coronavirus infection, comprising, as an active ingredient, a Psidiuma guajava extract, a pheophytin fraction thereof, or a meroterpenoid-based compound isolated therefrom. By increasing, through a chemical method, the content of a porphyrin-related compound, which is an active compound, while containing the meroterpenoid-based compound, the composition may be advantageously used in the treatment and prevention of novel coronavirus infection through synergistic interactions of antiviral activity.
PCT/KR2022/002045 2021-02-10 2022-02-10 Composition for preventing or treating novel coronavirus infection, comprising psidiuma guajava extract, pheophytin fraction thereof, or meroterpenoid-based compound isolated therefrom as active ingredient WO2022173246A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020210019447A KR20220115432A (en) 2021-02-10 2021-02-10 Composition for prevention or treatment of severe acute respiratory syndrome corona virus infection comprising extract of leaves or fruits of Psidium guajava or pheophytinized fraction or meroterpenoids isolated from therefrom as active ingredients
KR10-2021-0019447 2021-02-10

Publications (2)

Publication Number Publication Date
WO2022173246A2 WO2022173246A2 (en) 2022-08-18
WO2022173246A3 true WO2022173246A3 (en) 2022-10-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2022/002045 WO2022173246A2 (en) 2021-02-10 2022-02-10 Composition for preventing or treating novel coronavirus infection, comprising psidiuma guajava extract, pheophytin fraction thereof, or meroterpenoid-based compound isolated therefrom as active ingredient

Country Status (2)

Country Link
KR (1) KR20220115432A (en)
WO (1) WO2022173246A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190053490A (en) * 2017-11-10 2019-05-20 동성제약주식회사 Process for preparing high purity pheophytin, Chlorin e6, and Chlorin e6 and PVP complex from natural products containing chlorophyll

Family Cites Families (6)

* Cited by examiner, † Cited by third party
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KR101072905B1 (en) 2010-02-04 2011-10-17 노상근 The anti-diabetic composition containing extracts of Psidium guajava and Acanthopanax senticosus
KR101320946B1 (en) 2011-04-01 2013-10-23 경희대학교 산학협력단 Composition for Treating Prostate Cancer Comprising Hexane Fraction from Guava Leaf Extract As Active Ingredient
KR101491493B1 (en) 2013-04-04 2015-02-09 한국식품연구원 Anti-inflammatory pharmaceutical composition comprising tangerine pericarp and Psidium guajava extract
KR102176525B1 (en) 2018-11-07 2020-11-10 한국과학기술원 Method of Preparing Hierarchical Wrinkle Structure by Using Sacrificial Layer and Hierarchical Wrinkle Structure Prepared Thereby
KR102169476B1 (en) 2020-05-20 2020-10-23 (주)신테카바이오 Composition for preventing or treating sars coronavirus 2 infection disease
KR20200131784A (en) 2020-11-04 2020-11-24 (주)신테카바이오 Composition for preventing or treating sars coronavirus 2 infection disease

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190053490A (en) * 2017-11-10 2019-05-20 동성제약주식회사 Process for preparing high purity pheophytin, Chlorin e6, and Chlorin e6 and PVP complex from natural products containing chlorophyll

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ARIMA H., DANNO G.I.: "ISOLATION OF ANTIMICROBILA COMPOUNDS FROM GUAVA (PSIDIUM GUAJAVA L.)AND THEIR STRUCTURAL ELUCIDATION", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, JP, vol. 66, no. 8, 1 January 2002 (2002-01-01), JP , pages 1727 - 1730, XP007901748, ISSN: 0916-8451, DOI: 10.1271/bbb.66.1727 *
AZIM KAZI FAIZUL, AHMED SHEIKH RASHEL, BANIK ANIK, KHAN MD MOSTAFIGUR RAHMAN, DEB ANAMIKA, SOMANA SANEYA RISA: "Screening and druggability analysis of some plant metabolites against SARS-CoV-2: An integrative computational approach", INFORMATICS IN MEDICINE UNLOCKED, ELSEVIER, vol. 20, 1 January 2020 (2020-01-01), pages 100367, XP055975549, ISSN: 2352-9148, DOI: 10.1016/j.imu.2020.100367 *
DE JESUS MAURICE, JESUS, GAZA JOKENT T, JUNIO HIYAS, NELLAS RICKY: "Molecular docking of secondary metabolites from Psidium guajava L. and Piper nigrum L. to COVID-19 associated receptors ACE2, spike protein RBD, and TMPRSS2. ", CHEMRXIV, INSTITUTE OF CHEMISTRY, COLLEGE OF SCIENCE, UNIVERSITY OF THE PHILIPPINES DILIMAN, 26 August 2020 (2020-08-26), pages 1 - 27, XP055975553, [retrieved on 20221027] *
ILBO KUKMIN: "The Proven Effect of Guava-Green Tea Leaves·Roses on Antivirals... Expecting Them to Be Used as a Cure for COVID-19", SAMSUNG, 28 December 2020 (2020-12-28), pages 1 - 5, XP055975564, Retrieved from the Internet <URL:http://news.kmib.co.kr/article/view.asp?arcid=0924171484> [retrieved on 20221027] *
QIN XU-JIE, YU QIAN, YAN HUAN, KHAN AFSAR, FENG MI-YAN, LI PAN-PAN, HAO XIAO-JIANG, AN LIN-KUN, LIU HAI-YANG: "Meroterpenoids with Antitumor Activities from Guava ( Psidium guajava )", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 65, no. 24, 21 June 2017 (2017-06-21), US , pages 4993 - 4999, XP055975565, ISSN: 0021-8561, DOI: 10.1021/acs.jafc.7b01762 *
RYU BYEOL, CHO HYO MOON, ZHANG MI, LEE BA WOOL, DOAN THI PHUONG, PARK EUN JIN, LEE HEE JU, OH WON KEUN: "Meroterpenoids from the leaves of Psidium guajava (guava) cultivated in Korea using MS/MS-based molecular networking", PHYTOCHEMISTRY, ELSEVIER, AMSTERDAM , NL, vol. 186, 1 June 2021 (2021-06-01), Amsterdam , NL , pages 112723, XP055975567, ISSN: 0031-9422, DOI: 10.1016/j.phytochem.2021.112723 *

Also Published As

Publication number Publication date
KR20220115432A (en) 2022-08-17
WO2022173246A2 (en) 2022-08-18

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