WO2022141481A1

WO2022141481A1 - Radio frequency transmission quadrupole rod power source circuit and control method therefor, and power source device

Info

Publication number: WO2022141481A1
Application number: PCT/CN2020/142339
Authority: WO
Inventors: 熊亮; 张涛; 朱辉; 齐彦兵; 王攀攀; 范荣荣; 黄晓; 张伟
Original assignee: 广州禾信仪器股份有限公司; 昆山禾信质谱技术有限公司
Priority date: 2020-12-29
Filing date: 2020-12-31
Publication date: 2022-07-07
Also published as: CN112635288A

Abstract

The present application relates to a radio frequency transmission quadrupole rod power source circuit and a control method therefor, and a power source device. A plurality of different radio frequency magnetic ring transformers are arranged. During the transmission of ions having different mass ranges and different mass numbers, different radio frequency magnetic ring transformers can be correspondingly gated by means of a first gating device and a second gating device. Therefore, the transmission of ions having a very wide mass range from a small mass number of ions to a large mass number of ions can be realized. Radio frequency high-voltage electric fields flexibly matching different frequency bands are generated, such that a good efficiency of transmission of ions having a wide mass range and a good instrumental sensitivity are achieved. In addition, by means of a feedback apparatus, a closed-loop control architecture is realized, such that the radio frequency transmission quadrupole rod power source circuit has an extremely high adaptability and stability, and therefore, the application range of a mass spectrometer can be greatly increased.

Description

Radio frequency transmission quadrupole power supply circuit and its control method, power supply equipment

technical field

The present application relates to the technical field of ion transmission, and in particular, to a radio frequency transmission quadrupole power supply circuit, a control method thereof, and a power supply device.

Background technique

Mass Spectrometry is an analytical method for the determination and analysis of the mass-to-charge ratio (m/q) of the ions of the tested sample. Firstly, the uncharged sample to be tested is ionized, and then the ions are separated according to the mass-to-charge ratio by the method of electric field or magnetic field to obtain the mass spectrum. By analyzing the mass spectrum and related information of the sample, the qualitative and quantitative results of the sample can be obtained. Commonly used mass spectrometers are divided into analyzers, which are mainly divided into magnetic deflection mass spectrometers, quadrupole mass spectrometers, ion trap mass spectrometers and time-of-flight mass spectrometers.

With the development of mass spectrometry technology, the instrument performance indicators of mass spectrometers are constantly improving, and new methods and technologies are constantly being introduced. Among them, the introduction of radio frequency transmission quadrupole collision cooling focusing technology in the time-of-flight mass spectrometer, as an ion transmission system, has a good effect on the improvement of ion transmission efficiency and the enhancement of instrument sensitivity. When the RF transmission quadrupole works, it is necessary to add a high-frequency high-frequency electric field with a specific frequency and amplitude. For ions with different mass numbers and mass ranges, the added frequency range and amplitude are very different, which is very important for the high-frequency RF power supply. The control method and technology of the electric field have high requirements.

However, in the current time-of-flight mass spectrometer, for the radio frequency transmission quadrupole, it is necessary to achieve ion transmission in a very wide mass range from low mass ions to high mass ions, especially the low mass within 20 to the high mass above 4500. It can generate high-frequency high-frequency electric fields with flexible matching in different frequency bands, and achieve good ion transmission efficiency in a wide mass range and instrument sensitivity, as well as adaptability and stability. There is no mature method and scheme, which makes the application field of the instrument also subject to great restrictions.

SUMMARY OF THE INVENTION

Based on this, it is necessary to provide a radio frequency transmission quadrupole power supply circuit, a control method and a power supply device for the problem that the application field of the traditional time-of-flight mass spectrometer is limited.

A radio frequency transmission quadrupole power supply circuit, comprising: a control device, a sine wave generating device, an amplifying device, a first gating device, a second gating device, a plurality of radio frequency magnetic ring transformers, a radio frequency transmission quadrupole and a feedback adjustment The control device is connected to the sine wave generating device, the sine wave generating device is connected to the amplifying device, the amplifying device is connected to the first gating device, and the primary sides of the radio frequency magnetic toroidal transformers are respectively The first gating device is connected, the secondary side of each radio frequency magnetic toroidal transformer is respectively connected with the second gating device, the second gating device is connected with the radio frequency transmission quadrupole, and the radio frequency transmission quadrupole The pole rod is connected to the feedback adjustment device, the feedback adjustment device is connected to the control device, the feedback adjustment device is connected to the amplification device, the amplification device, the first gating device, and each of the radio frequency magnetic rings The secondary tap of the transformer and the second gating device are respectively connected to the control device.

In one embodiment, the amplifying device includes a variable gain amplifier programmable amplitude modulator, an in-phase multi-stage amplifier circuit and an inverting multi-stage amplifier circuit, and the variable gain amplifier programmable amplitude modulator is connected to the sine wave generating device and the feedback The adjusting device, the in-phase multi-stage amplifying circuit and the inverting multi-stage amplifying circuit are respectively connected to the variable gain amplification program-controlled amplitude modulator, and the in-phase multi-stage amplifying circuit and the inverting multi-stage amplifying circuit are respectively connected to the The first gating device, the in-phase multi-stage amplifier circuit and the inverting multi-stage amplifier circuit are respectively connected to the control device.

In one embodiment, the non-inverting multi-stage amplifier circuit includes a non-inverting amplifier, a first-stage power amplifier and a second-stage power amplifier, the non-inverting amplifier is connected to a variable gain amplification programmable amplitude modulator, and the non-inverting amplifier is connected to the first power amplifier. A first-stage power amplifier, the first-stage power amplifier is connected to the second-stage power amplifier, the second-stage power amplifier is connected to the first gating device, the non-inverting amplifier, the first-stage power amplifier and The second-stage power amplifiers are respectively connected to the control device; and/or, the inverting multi-stage amplifier circuit includes an inverting amplifier, a first-stage amplifier and a second-stage amplifier, and the inverting amplifier is connected to a variable gain Amplifying programmable amplitude modulator, the inverting amplifier is connected to the first-stage amplifier, the first-stage amplifier is connected to the second-stage amplifier, the second-stage amplifier is connected to the first gating device, and the inverting amplifier is connected to the first gate device. The phase amplifier, the first-stage amplifier and the second-stage amplifier are respectively connected to the control device.

In one embodiment, the control device includes a main controller, a power supply and current monitor, a gating controller, and a medium and low voltage generator, the main controller is connected to the sine wave generating device, and the feedback device is connected to the main controller, the power supply and current monitor, the gating controller and the medium and low voltage generator are respectively connected to the main controller, the power supply and current monitor are connected to the amplifying device, The gating controller is connected to the first gating device and the second gating device, and the medium and low voltage generators are connected to the secondary taps of each of the radio frequency magnetic toroidal transformers.

In one embodiment, the feedback adjustment device includes a detection circuit, an amplitude monitor, a digital-to-analog controller and a proportional-integral regulator, the detection circuit is connected to the radio frequency transmission quadrupole, and the detection circuit is connected to the A proportional-integral regulator and the amplitude monitor, the amplitude monitor and the digital-analog controller are respectively connected to the control device, the digital-analog controller is connected to the proportional-integral regulator, and the proportional-integral controller is connected to the proportional-integral regulator. A regulator is connected to the amplification device.

A control method for the above-mentioned radio frequency transmission quadrupole power supply circuit, comprising: obtaining a frequency setting value; The radio frequency magnetic toroidal transformer; by adjusting the sine wave generating device and the feedback adjusting device, the resonant frequency of the radio frequency transmission quadrupole power supply circuit at the minimum power consumption is obtained.

In one embodiment, the radio frequency magnetic toroidal transformer includes a low frequency band radio frequency toroidal transformer, a mid frequency band radio frequency toroidal transformer and a high frequency band radio frequency toroidal transformer, and the first gate is controlled according to the frequency setting value The step of gating the corresponding radio frequency magnetic toroidal transformer by the device and the second gating device includes: comparing and analyzing the frequency setting value and a preset first frequency range; when the frequency setting value is in the When the preset first frequency band is within the range, control the first gating device and the second gating device to gating the low-frequency radio frequency magnetic toroidal transformer; when the frequency setting value is not within the preset first frequency range; When it is within a frequency range, according to the comparison and analysis of the frequency setting value and the preset second frequency band range, the minimum threshold value of the preset second frequency band range is equal to the maximum threshold value of the preset first frequency band range; When the frequency setting value is within the preset second frequency band range, control the first gating device and the second gating device to gating the mid-band radio frequency magnetic toroidal transformer; when the frequency setting When the value is not within the preset second frequency band range, compare and analyze the frequency setting value and the preset third frequency band range, and the minimum threshold value of the preset third frequency band range is equal to the preset second frequency band range. the maximum threshold of the frequency band range; when the frequency setting value is within the preset third frequency band range, control the first gating device and the second gating device to gating the high-frequency radio frequency magnetic ring transformer.

In one embodiment, the step of obtaining the resonant frequency of the radio frequency transmission quadrupole power supply circuit with minimum power consumption by adjusting the sine wave generating device and the feedback adjusting device includes: adjusting the sine wave generating device and the feedback adjustment device, and collect the current value of the amplifying device in real time; when the minimum current value of the amplifying device is obtained, read the current frequency of the sine wave generating device, that is, the radio frequency transmission quadrupole power supply The resonant frequency at which the circuit consumes minimum power.

A radio frequency transmission quadrupole power supply device includes the above-mentioned radio frequency transmission quadrupole power supply circuit, and the control device is used for scanning and obtaining the resonance frequency with the minimum power consumption according to the above-mentioned control method.

In one embodiment, the radio frequency transmission quadrupole power supply equipment further includes a chassis, the control device, the sine wave generating device and the feedback adjustment device are integrated and arranged on the same main control board, the amplifying device, the The first gating device, the second gating device and a plurality of radio frequency magnetic toroidal transformers are integrally arranged on the same power amplifier board, and the main control board and the power amplifier board are pluggable and arranged in the chassis.

The above-mentioned radio frequency transmission quadrupole power supply circuit and its control method and power supply equipment, when starting to work, the control device firstly controls the sine wave generating device to generate a corresponding sine wave signal, and the sine wave signal and the signal fed back by the feedback device are passed through the amplification device together. After amplification, the control device and the corresponding radio frequency magnetic toroidal transformer connected under the gating of the first gating device and the second gating device are finally loaded into the radio frequency transmission quadrupole, and the radio frequency high voltage electric field is generated at the radio frequency transmission quadrupole. The above scheme is provided with a plurality of different radio frequency magnetic toroidal transformers. When carrying out ion transmission of different mass ranges and different mass numbers, different radio frequency magnetic toroidal transformers can be correspondingly selected by the first gating device and the second gating device. Therefore, ion transmission in a very wide mass range from low-mass ions to high-mass ions can be realized, and a radio frequency high-voltage electric field with flexible matching of different frequency bands can be generated, so as to achieve a good wide-mass range ion transmission efficiency and instrument sensitivity; , The closed-loop control structure is realized through the feedback device, so that the radio frequency transmission quadrupole power supply circuit has extremely high adaptability and stability, so the application range of the mass spectrometer can be greatly improved.

Description of drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application or in the traditional technology, the following briefly introduces the accompanying drawings that are used in the description of the embodiments or the traditional technology. Obviously, the drawings in the following description are only the For some embodiments of the application, for those of ordinary skill in the art, other drawings can also be obtained according to these drawings without any creative effort.

1 is a schematic structural diagram of a radio frequency transmission quadrupole power supply circuit in an embodiment;

2 is a schematic structural diagram of a radio frequency transmission quadrupole power supply circuit in another embodiment;

3 is a schematic diagram of a partial structure of an amplifying device in an embodiment;

4 is a schematic flowchart of a control method of a radio frequency transmission quadrupole power supply circuit in an embodiment;

5 is a schematic flowchart of a control method of a radio frequency transmission quadrupole power supply circuit in another embodiment;

6 is a schematic diagram of a gating control flow in an embodiment;

7 is a schematic diagram of a resonant frequency scanning process flow in an embodiment;

FIG. 8 is a schematic structural diagram of a radio frequency transmission quadrupole power supply device in an embodiment.

Detailed ways

In order to facilitate understanding of the present application, the present application will be described more fully below with reference to the related drawings. The preferred embodiments of the present application are shown in the accompanying drawings. However, the application may be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided so that a thorough and complete understanding of the disclosure of this application is provided.

Referring to FIG. 1, a radio frequency transmission quadrupole power supply circuit includes: a control device 10, a sine wave generating device 20, an amplifying device 30, a first gating device 40, a second gating device 60, a plurality of radio frequency magnetic rings The transformer 50, the radio frequency transmission quadrupole 70 and the feedback adjustment device 80, the control device 10 is connected to the sine wave generating device 20, the sine wave generating device 20 is connected to the amplifying device 30, the amplifying device 30 is connected to the first gating device 40, and each radio frequency magnetic ring The primary side of the transformer 50 is connected to the first gating device 40 respectively, the secondary side of each radio frequency magnetic toroidal transformer 50 is respectively connected to the second gating device 60, the second gating device 60 is connected to the radio frequency transmission quadrupole 70, and the radio frequency transmission quadrupole The rod 70 is connected to the feedback adjustment device 80, the feedback adjustment device 80 is connected to the control device 10, the feedback adjustment device 80 is connected to the amplifying device 30, the amplifying device 30, the first gating device 40, and the secondary side tap of each radio frequency magnetic toroidal transformer 50 (not shown in the figure). shown) and the second gating device 60 are respectively connected to the control device 10.

Specifically, the sine wave generating device 20 , that is, the DDS sine wave signal generator, can generate sine wave signals of different frequencies through the sine wave generating device 20 under the action of the control device 10 . In one embodiment, according to the working requirements of the time-of-flight mass spectrometer using the radio frequency transmission quadrupole 70, the sine wave generating device 20 can specifically generate sine wave signals in three different frequency bands: high frequency band, mid frequency band and low frequency band. At the same time, in the radio frequency transmission quadrupole power supply circuit of this embodiment, a plurality of radio frequency magnetic toroidal transformers 50 with different frequency ranges are provided. Under the action of the control device 10 and the first gating device 40, the corresponding required frequency band can be selected The primary side of the radio frequency toroidal transformer 50 in the range is connected to the circuit, and under the action of the control device 10 and the second gating device 60 , the secondary side of the radio frequency toroidal transformer 50 corresponding to the required frequency range can be connected to the circuit. Therefore, one of the radio frequency transmission quadrupole power supply circuits is connected to the circuit to work to meet the needs of ions in different mass ranges, and then ion transmission from low mass numbers within 20 to high mass numbers above 4500 can be realized.

At the same time, the solution of this embodiment adopts an amplitude closed-loop feedback control loop in hardware, and the output waveform of the radio frequency transmission quadrupole 70 can be collected in real time through the feedback device for feedback adjustment. When the amplitude fluctuates, it will be compensated by feedback, which ensures that the RF high voltage amplitude applied to the RF transmission quadrupole is continuously stable and undisturbed, and the amplitude stability is within 0.1%, forming a stable and constant RF electric field. The secondary side taps of each radio frequency magnetic toroidal transformer 50 are respectively connected to the control device 10 , so that the control device 10 can generate a DC bias voltage and apply it to the middle tap end of the secondary side of the radio frequency magnetic toroidal transformer 50 , so as to provide the radio frequency magnetic toroidal transformer 50 The RF AC high voltage generated by the secondary side coil provides the DC bias reference voltage.

It should be pointed out that the specific types of the first gating device 40 and the second gating device 60 are not unique, and under the action of the control device 10 , different paths of the radio frequency magnetic toroidal transformer 50 can be connected to the circuit. For example, in one embodiment, both the first gating device 40 and the second gating device 60 may be implemented by using relays, wherein the first gating device 40 may be a power relay, and the second gating device 60 may be a power relay. High voltage relay is used.

Referring to FIG. 2, in one embodiment, the amplifying device 30 includes a variable gain amplifying programmable amplitude modulator 31, an in-phase multi-stage amplifying circuit 32 and an inverting multi-stage amplifying circuit 33, and the variable gain amplifying programmable amplitude modulator 31 is connected to a sine wave The generating device 20 and the feedback adjusting device 80, the in-phase multi-stage amplifier circuit 32 and the inverting multi-stage amplifier circuit 33 are respectively connected to the variable gain amplifier programmable amplitude modulator 31, and the in-phase multi-stage amplifier circuit 32 and the inverting multi-stage amplifier circuit 33 are respectively connected The first gating device 40 , the in-phase multi-stage amplifying circuit 32 and the inverting multi-stage amplifying circuit 33 are respectively connected to the control device 10 .

Specifically, the variable gain amplification programmable amplitude modulator 31 can perform amplitude modulation, is connected to the sine wave generating device 20 and the feedback device, and can receive the sinusoidal carrier signal of the sine wave generating device 20 and the feedback signal fed back by the feedback adjustment device 80 together to modulate. The modulated AM wave is divided into two paths, the phases of the two sine wave signals differ by 180°, one of which is in-phase power amplification by the in-phase multi-stage amplifying circuit 32, and the other is inverting by the in-phase multi-stage amplifying circuit 33. Power amplification. After that, the controller controls the first gating device 40 to perform gating, and selects a corresponding radio frequency magnetic toroidal transformer 50 among the plurality of radio frequency magnetic toroidal transformers 50 to connect to the circuit, so that the two amplified sine wave signals have a phase difference of 180°. Input from the two ends of the primary side coil of the radio frequency toroidal transformer 50 respectively, pass through the two ends of the secondary coil (that is, the secondary winding) of the radio frequency toroidal transformer 50 and the second gating device 60, and finally load it into the radio frequency Transmission quadrupole 70 .

It can be understood that, in order to ensure that the radio frequency transmission quadrupole 70 can generate a radio frequency high-voltage electric field, the two-way sine wave signals output after passing through the second gating device 60 are respectively loaded into any two adjacent rods of the radio frequency transmission quadrupole 70 (No. One group of adjacent rods), and the two groups of adjacent rods of the radio frequency transmission quadrupole 70 are connected and conducted, and two sine wave signals can be output through the other group of adjacent rods. The solution of this embodiment adopts a multi-stage power amplifying circuit structure for ions of different frequency bands and different mass ranges, and has a high RF high-voltage amplitude driving capability.

It should be noted that the specific structures of the non-inverting multi-stage amplifier circuit 32 and the inverting multi-stage amplifier circuit 33 are not unique. In one embodiment, please refer to FIG. The first-stage power amplifier 322 and the second-stage power amplifier 323, the non-inverting amplifier 321 is connected to the variable gain amplifier programmable amplitude modulator 31, the non-inverting amplifier 321 is connected to the first-stage power amplifier 322, and the first-stage power amplifier 322 is connected to the second-stage power amplifier 323, the second-stage power amplifier 323 is connected to the first gating device 40, the non-inverting amplifier 321, the first-stage power amplifier 322 and the second-stage power amplifier 323 are respectively connected to the control device 10; and/or, the inverting multi-stage amplifier circuit 33 It includes an inverting amplifier 331, a first-stage amplifier 332 and a second-stage amplifier 333. The inverting amplifier 331 is connected to the variable gain amplifier programmable amplitude modulator 31, the inverting amplifier 331 is connected to the first-stage amplifier 332, and the first-stage amplifier 332 is connected to the first-stage amplifier 332. The second stage amplifier 333 and the second stage amplifier 333 are connected to the first gating device 40 , and the inverting amplifier 331 , the first stage amplifier 332 and the second stage amplifier 333 are respectively connected to the control device 10 .

Specifically, in the solution of this embodiment, the two channels of sine wave signals output by the programmable amplitude modulator 31 are amplified by the variable gain, and one channel of the signals is amplified and output in-phase by the non-inverting amplifier 321 , the first-stage power amplifier 322 and the second-stage power amplifier 323 . The power amplified sine wave is amplified by the inverting amplifier 331, the first-stage amplifier 332, and the second-stage amplifier 333, and then outputs an inverting power amplified sine wave. The phase difference between the two sine waves is 180°. After being gated by the power relay (ie, the first gating device 40 ), it is loaded to the two ends of the primary side coil of the radio frequency magnetic toroidal transformer 50 that is turned on, and is boosted by the turns ratio of the radio frequency magnetic toroidal transformer 50 . The two ends of the secondary side coil of 50 output two channels of RF high-voltage sine waves with a phase difference of 180°, which are gated by the high-voltage relay (ie the second gating device 60) and added to the two adjacent rods of the RF transmission quadrupole, A radio frequency high voltage electric field is formed, the two pairs of rods of the radio frequency transmission quadrupole are connected and conducted, and the other group of adjacent rods outputs two channels of radio frequency high voltage sine waves.

The specific structures of the first-stage power amplifier 322, the second-stage power amplifier 323, and the first-stage amplifier 332 and the second-stage amplifier 333 are not unique. In one embodiment, please refer to FIG. 3 in conjunction with the first-stage power amplifier. 322 includes a first amplifier K1, a first resistor R1, a second resistor R2 and a third resistor R3, the second stage power amplifier 323 includes a first switch Q1 and a second switch Q2, and the first stage amplifier 332 includes a second amplifier K2, the fourth resistor R4, the fifth resistor R5 and the sixth resistor R6, the second-stage amplifier 333 includes a third switch Q3 and a fourth switch Q4; one end of the first resistor R1 is connected to the forward input of the first amplifier K1 The other end of the first resistor R1 is connected to the non-inverting amplifier 321, the inverting input end of the first amplifier K1 is connected to one end of the second resistor R2 and one end of the third resistor R3, the other end of the second resistor R2 is grounded, and the third resistor The other end of R3 is connected to the output end of the first amplifier K1, the control end of the first switch tube Q1 and the control end of the second switch tube Q2, the first end of the first switch tube Q1 is connected to the power supply, and the first end of the first switch tube Q1 The two ends are connected to the first end of the second switch tube Q2 and the first gating device 40 (not shown), the second end of the second switch tube Q2 is connected to the power supply; one end of the fourth resistor R4 is connected to the positive terminal of the second amplifier K2 To the input end, the other end of the fourth resistor R4 is connected to the inverting amplifier 331, the inverting input end of the second amplifier K2 is connected to one end of the fifth resistor R5 and one end of the sixth resistor R6, and the other end of the fifth resistor R5 is grounded, The other end of the sixth resistor R6 is connected to the output end of the second amplifier K2, the control end of the third switch tube Q3 and the control end of the fourth switch tube Q4, the first end of the third switch tube Q3 is connected to the power supply, and the third switch tube Q3 is connected to the power supply. The second end of Q3 is connected to the first end of the fourth switch tube Q4 and the first gating device 40 , and the second end of the fourth switch tube Q4 is connected to the power supply.

Specifically, the sine wave in-phase signal VIN1 output by the non-inverting amplifier 321 and the sine wave in-phase signal VIN2 output by the inverting amplifier 331 pass through the first-stage high-speed power operational amplifier (that is, the first amplifier K1 and the second amplifier respectively). K2) Amplify at the same ratio, enter the dual power supply common collector triode complementary push-pull power amplifier circuit in the second-stage power amplifier 323 and the second-stage amplifier 333 respectively, the output in-phase and anti-phase two channels have good current drive and voltage drive capability The sine wave power signal is applied to both ends of the primary side of the corresponding RF magnetic ring transformer 50 after gating. The RF magnetic ring used can have extremely low loss and boost magnification at the resonance point of the RF frequency band. . After the first-level power amplifier, the second-level power amplifier and the dedicated RF magnetic toroidal transformer 50, the secondary side of the RF magnetic toroidal transformer 50 can output high-amplitude RF high-voltage, which can well meet the requirements of different frequency bands and different mass numbers of ions. RF high voltage requirements.

It should be noted that, in one embodiment, the radio frequency magnetic toroidal transformer 50 adopts a transformer coil made of special material to ensure the working reliability of the radio frequency magnetic toroidal transformer 50, which may be carbonyl iron powder magnetic core material.

Referring to FIG. 2 , in one embodiment, the control device 10 includes a main controller 11 , a power supply and current monitor 12 , a gating controller 13 and a medium and low voltage generator 14 , and the main controller 11 is connected to the sine wave generating device 20 , the feedback device is connected to the main controller 11, the power supply and current monitor 12, the gating controller 13 and the medium and low voltage generator 14 are respectively connected to the main controller 11, the power supply and the current monitor 12 are connected to the amplifying device 30, and the gating control The generator 13 is connected to the first gating device 40 and the second gating device 60 , and the medium and low voltage generator 14 is connected to the secondary taps of each radio frequency magnetic toroidal transformer 50 .

Specifically, the control device 10 includes a main controller 11 that implements a main control function, a power supply and current monitor 12 that monitors the power supply and current of the amplifying device 30, and is used to control the first gating device 40 and the second selection device 40. The gating controller 13 for operating the pass device 60 in the corresponding channel, and the medium and low voltage generator 14 for supplying the taps of the secondary coils of each radio frequency toroidal transformer 50 with DC bias voltage. When the radio frequency transmission quadrupole power supply circuit is turned on, the main controller 11 sends a control instruction to the gating controller 13, so that the gating controller 13 controls the first gating device 40 and the second gating device 60 to corresponding channels operation, so that the corresponding radio frequency magnetic toroidal transformer 50 is connected to the circuit; at the same time, the medium and low voltage generator 14 is controlled to provide a DC bias current to the secondary coil of the radio frequency magnetic toroidal transformer 50, and finally a high-voltage electric field is generated at the radio frequency transmission quadrupole 70. , the power supply and current monitor 12 can collect the magnitude of the current flowing through the amplifying device 30, and then quickly and accurately scan the resonant frequency of the minimum power consumption of the radio frequency transmission quadrupole power supply circuit.

Referring to FIG. 2, in one embodiment, the feedback adjustment device 80 includes a detection circuit 81, an amplitude monitor 84, a digital-to-analog controller 82, and a proportional-integral regulator 83. The detection circuit 81 is connected to the radio frequency transmission quadrupole 70, and the detection The circuit 81 is connected to the proportional-integral regulator 83 and the amplitude monitor 84, the amplitude monitor 84 and the digital-analog controller 82 are respectively connected to the control device 10, the digital-analog controller 82 is connected to the proportional-integral regulator 83, and the proportional-integral regulator 83 is connected Amplifying device 30 .

Specifically, after the two-way RF high-voltage sine wave output by the RF transmission quadrupole 70 is collected and analyzed by the detection circuit 81, the output feedback signal is added to the proportional integral regulator 83 (PI regulator), and the main controller 11 is passed through the DA The control signal generated by the control (that is, the digital-analog controller 82), is adjusted by PI to compare and amplify the error, forming a hardware closed-loop negative feedback, and finally the signal output by the PI regulator is fed back to the amplifying device 30, and real-time RF high-voltage sinusoidal The amplitude of the wave is compensated and controlled to ensure a stable and constant amplitude. At the same time, the feedback signal output by the detection circuit 81 is also returned to the main controller 11 through the amplitude monitor 84 for real-time monitoring of the amplitude, thereby forming a complete hardware closed-loop feedback control loop.

The above-mentioned radio frequency transmission quadrupole power supply circuit, when starting to work, the control device 10 first controls the sine wave generating device 20 to generate a corresponding sine wave signal, and the sine wave signal and the signal fed back by the feedback device are amplified by the amplifying device 30. The corresponding radio frequency magnetic toroidal transformer 50 connected by the control device 10 and the first gating device 40 and the second gating device 60 is loaded into the radio frequency transmission quadrupole 70, and a radio frequency high voltage is generated at the radio frequency transmission quadrupole 70. electric field. The above scheme is provided with a plurality of different radio frequency magnetic toroidal transformers 50. When carrying out ion transmission of different mass ranges and different mass numbers, different radio frequencies can be correspondingly gated through the first gating device 40 and the second gating device 60. The magnetic toroidal transformer 50 can realize ion transmission in a very wide mass range from low-mass ions to high-mass ions, generate radio frequency high-voltage electric fields flexibly matched in different frequency bands, and achieve good ion transmission efficiency in a wide mass range and Instrument sensitivity; at the same time, the closed-loop control structure is realized through the feedback device, so that the radio frequency transmission quadrupole power supply circuit has a very high degree of adaptability and stability, so it can greatly improve the application range of the mass spectrometer.

Please refer to FIG. 4 , a control method of the above-mentioned radio frequency transmission quadrupole power supply circuit includes step S100 , step S200 and step S300 .

Step S100, obtaining a frequency setting value; Step S200, controlling the radio frequency magnetic toroidal transformer corresponding to the first gating device and the second gating device gating according to the frequency setting value; Step S300, adjusting the sine wave generating device and feedback adjustment The device is used to obtain the resonant frequency at the minimum power consumption of the radio frequency transmission quadrupole power supply circuit.

Specifically, the specific structure of the radio frequency transmission quadrupole power supply circuit is as shown in the above embodiments and the accompanying drawings. When the radio frequency transmission quadrupole power supply circuit provided by the present application is turned on and works, a wide frequency range and fine step frequency scanning are adopted. The program algorithm, in different frequency bands, for the RF transmission quadrupole with different equivalent capacitance and the matching inductance coil on the secondary side of the RF magnetic toroidal transformer 50, can quickly and accurately scan the minimum power consumption with one key. Resonant frequency. First, the control device 10 obtains a frequency setting value. The frequency setting value may be directly input to the control device 10 by the user, or may be sent by a host computer or a user terminal connected to the control device 10 .

Afterwards, the control device 10 controls the first gating device 40 and the second gating device 60 to select different radio frequency magnetic toroidal transformers 50 according to the received set frequency, and continuously adjusts the input of the amplifying device 30 . , and finally scan to obtain the resonant frequency with the minimum power consumption, so that the radio frequency transmission quadrupole power supply circuit has a good adaptive ability.

The method of scanning to obtain the resonance frequency is not unique. Please refer to FIG. 5 . In one embodiment, step S300 includes step S310 and step S320.

Step S310, adjust the sine wave generating device and the feedback adjustment device, and collect the current value of the amplifying device in real time; Step S320, when the minimum current value of the amplifying device is obtained, read the current frequency of the sine wave generating device, which is the radio frequency transmission four. The resonant frequency at which the pole power circuit has minimum power dissipation.

Specifically, when the control device 10 adjusts the sine wave generating device 20 and the feedback adjustment device 80, the corresponding signal loaded to the amplifying device 30 will also change. At this time, the control device 10 supplies power and the current monitor 12 by receiving power. The collected and sent current signal is analyzed, and when the minimum current signal is obtained, the frequency corresponding to the minimum current signal can be taken as the resonant frequency.

Referring to FIG. 6 , in one embodiment, the radio frequency magnetic toroidal transformer 50 includes a low-frequency radio frequency toroidal transformer 50, a mid-frequency radio frequency toroidal transformer 50 and a high-frequency radio frequency toroidal transformer 50, and step S200 includes steps S210, S220, Step S230, Step S240, Step S250 and Step S260.

Step S210, compare and analyze the frequency setting value and the preset first frequency band range; Step S220, control the first gating device and the second gating device to select when the frequency setting value is within the preset first frequency band range. Connect the low-frequency radio frequency magnetic toroidal transformer; Step S230, when the frequency setting value is not within the preset first frequency band range, compare and analyze the frequency setting value and the preset second frequency band range; The minimum threshold value is equal to the maximum threshold value of the preset first frequency band range; Step S240, when the frequency setting value is within the preset second frequency band range, control the first gating device and the second gating device to gating the mid-band radio frequency magnetic ring Transformer; Step S250, when the frequency setting value is not within the preset second frequency band range, compare and analyze the frequency setting value and the preset third frequency band range; the minimum threshold value of the preset third frequency band range is equal to the preset first frequency band range. The maximum threshold of the second frequency band range; step S260, when the frequency setting value is within the preset third frequency band range, control the first gating device and the second gating device to gating the high frequency band radio frequency magnetic toroidal transformer.

Specifically, referring to FIG. 7 , the radio frequency transmission quadrupole power supply circuit is powered on to perform system initialization, and the control device 10 first reads the Freg set frequency value (that is, the above-mentioned frequency set value) sent by the host computer, and starts to judge Set whether the frequency value is within the preset first frequency range, that is, whether it is between the frequencies of FS1 and FE1. If the judgment result is yes, the gating channel 1 is turned on, the power relay (the first gating device 40 ) and the high voltage relay (the second gating device 60 ) are gating the first channel, and the low-frequency radio frequency magnetic toroidal transformer 50 is turned on. After that, the output of the digital-analog controller 82 (DAC) in the feedback adjustment device 80 can be adjusted continuously and finely and the output of the DDS frequency (that is, the sine wave generating device 20 ) can be adjusted. 12. Carry out current signal acquisition, cycle to find the minimum current value of the amplifying device 30, and when the minimum current value is finally found, read the current actual frequency value Freg. Determine whether the frequency value is within the preset first frequency band. If it is, it means that a matching resonance frequency within the preset first frequency band has been found, and the frequency scan is over; if not, it means that there is an error in the connection of the radio frequency transmission quadrupole load. , the program ends.

If the set frequency value is not within the preset first frequency band range as a result of the judgment, then it is then judged whether the set frequency value is within the preset second frequency band range, that is, whether it is between FS2 and FE2 frequencies. If yes, turn on the gating channel 2, the power relay and the high-voltage relay are gating the second channel, and the mid-band RF magnetic toroidal transformer 50 is turned on. Also, adjust the output of the digital-analog controller 82 and adjust the DDS frequency output through fine steps. The power supply and current monitor 12 of the control device 10 collects the current signal, searches for the minimum current value of the amplifying device 30 cyclically, and reads the current actual frequency value Freg when the minimum current value is finally found. Determine whether the frequency value is within the preset second frequency band. If it is, it means that a matching resonant frequency within the preset second frequency band has been found, and the frequency scan ends; if not, it means that there is an error in the connection of the radio frequency transmission quadrupole load. , the program ends.

If the set frequency value is still not within the preset second frequency band range, it is then judged whether the set frequency value is within the preset third frequency band range, that is, whether it is between FS3 and FE3 frequencies. If yes, turn on the gating channel 3, the power relay and the high-voltage relay are gating the third channel, the high-frequency radio frequency magnetic toroidal transformer 50 is turned on, and also adjust the DAC output and the DDS frequency output by continuously fine-stepping, through the control device 10 The power supply and current monitor 12 collects the current signal, searches for the minimum current value of the amplifying device 30 cyclically, and reads the current actual frequency value Freg when the minimum current value is finally found. Determine whether the frequency value is within the preset third frequency band. If yes, it means that the matching resonance frequency in the preset third frequency band has been found, and the frequency scan is over; At the end of the program, a fast and accurate resonant frequency scan is achieved at the moment of power-on.

It should be noted that the relationship between the preset first frequency range, the preset second frequency range, and the preset third frequency range is FS1<FE1=FS2<FE2=FS3<FE3. In one embodiment, when collecting the current signal through the power supply of the control device 10 and the current monitor 12, and cyclically searching for the minimum current value of the amplifying device 30, it may be cyclically searching for one minute, and the lowest current value in this minute is The current value is used as the minimum current value of the amplifying device 30 to achieve fast and accurate resonant frequency scanning.

The control method of the above-mentioned radio frequency transmission quadrupole power supply circuit adopts the frequency scanning program algorithm with wide frequency range and fine step, and realizes the flexible switching gating and resonance of radio frequency high voltage in three frequency bands of high, middle and low frequency according to the transmission quadrupole of different capacitance characteristics. The frequency is automatically scanned quickly and accurately.

A radio frequency transmission quadrupole power supply device includes the above radio frequency transmission quadrupole power supply circuit, and the control device 10 is configured to scan and obtain the resonant frequency with the minimum power consumption according to the above control method.

Specifically, the specific structure of the radio frequency transmission quadrupole power supply circuit is shown in the above-mentioned embodiments and the accompanying drawings. The sine wave generating device 20 is also the DDS sine wave signal generator. Under the action of the control device 10, the sine wave generates The device 20 can generate sine wave signals of different frequencies. In one embodiment, according to the working requirements of the time-of-flight mass spectrometer using the radio frequency transmission quadrupole 70, the sine wave generating device 20 can specifically generate sine wave signals in three different frequency bands: high frequency band, mid frequency band and low frequency band. At the same time, in the radio frequency transmission quadrupole power supply circuit of this embodiment, a plurality of radio frequency magnetic toroidal transformers 50 with different frequency ranges are provided. Under the action of the control device 10 and the first gating device 40, the corresponding required frequency band can be selected The primary side of the radio frequency toroidal transformer 50 in the range is connected to the circuit, and under the action of the control device 10 and the second gating device 60 , the secondary side of the radio frequency toroidal transformer 50 corresponding to the required frequency range can be connected to the circuit. Therefore, one of the radio frequency transmission quadrupole power supply circuits is connected to the circuit to work to meet the needs of ions in different mass ranges, and then ion transmission from low mass numbers within 20 to high mass numbers above 4500 can be realized.

When the RF transmission quadrupole power supply circuit is turned on, it adopts a frequency scanning program algorithm with a wide frequency range and fine steps. The inductance coil on the secondary side of the toroidal transformer 50 can quickly and accurately scan the resonant frequency with the minimum power consumption with one click. First, the control device 10 obtains a frequency setting value. The frequency setting value may be directly input to the control device 10 by the user, or may be sent by a host computer or a user terminal connected to the control device 10 .

In one embodiment, the radio frequency transmission quadrupole power supply device further includes a chassis, the control device 10 , the sine wave generating device 20 and the feedback adjustment device 80 are integrated on the same main control board, the amplifying device 30 and the first gating device 40 , The second gating device 60 and a plurality of radio frequency magnetic toroidal transformers 50 are integrated and arranged on the same power amplifier board, and the main control board and the power amplifier board are pluggable and arranged in the chassis.

Specifically, the number of power amplifier boards in this embodiment is multiple. For ease of understanding, please refer to FIG. 8 in conjunction with FIG. 8 . In a more detailed embodiment, the number of power amplifier boards is two for description, that is, the first The power amplifier board 500 and the second power amplifier board 600, the two power amplifier boards are two boards with the same structure and function. Among them, there are certain differences in the windings of the RF magnetic toroidal transformer 50, which are used for different RF transmission quadrupoles. high voltage electric field. The main control board 400 , the first power amplifier board 500 and the second power amplifier board 600 can be quickly inserted into and pulled out of the chassis 700 . The main control board 400 communicates with the outside and provides control signals to the first power amplifier board 500 and the second power amplifier board 600. The first power amplifier board 500 provides the first group of radio frequency transmission quadrupoles with a high-frequency radio frequency electric field. The two power amplifier board 600 provides the radio frequency high voltage electric field to the second group of radio frequency transmission quadrupoles. According to different requirements of the radio frequency transmission quadrupole, the first power amplifier board 500 and the second power amplifier board 600 can realize fast custom design and arbitrary plugging and replacement, and can be maintained more conveniently.

The above-mentioned radio frequency transmission quadrupole power supply equipment adopts an integrated mechanical structure of plug-in modules, so that each functional module can be quickly customized design and maintenance and replacement according to different radio frequency transmission quadrupole rod requirements, which has strong operational convenience.

The technical features of the above-described embodiments can be combined arbitrarily. For the sake of brevity, all possible combinations of the technical features in the above-described embodiments are not described. However, as long as there is no contradiction between the combinations of these technical features, All should be regarded as the scope described in this specification.

The above-mentioned embodiments only represent several embodiments of the present application, and the descriptions thereof are relatively specific and detailed, but should not be construed as a limitation on the scope of the patent application. It should be pointed out that for those skilled in the art, without departing from the concept of the present application, several modifications and improvements can be made, which all belong to the protection scope of the present application. Therefore, the scope of protection of the patent of the present application shall be subject to the appended claims.

Claims

A radio frequency transmission quadrupole power supply circuit is characterized by comprising: a control device, a sine wave generating device, an amplifying device, a first gating device, a second gating device, a plurality of radio frequency magnetic ring transformers, a radio frequency transmission quadrupole lever and feedback adjustment device,

The control device is connected to the sine wave generating device, the sine wave generating device is connected to the amplifying device, the amplifying device is connected to the first gating device, and the primary sides of the radio frequency magnetic toroidal transformers are respectively connected to the the first gating device, the secondary side of each radio frequency toroidal transformer is respectively connected to the second gating device, the second gating device is connected to the radio frequency transmission quadrupole, the radio frequency transmission quadrupole connected to the feedback adjustment device, the feedback adjustment device is connected to the control device, the feedback adjustment device is connected to the amplifying device, the amplifier device, the first gating device, the radio frequency magnetic toroidal transformer The secondary side tap and the second gating device are respectively connected to the control device.
The radio frequency transmission quadrupole power supply circuit according to claim 1, wherein the amplifying device comprises a variable gain amplifying programmable amplitude modulator, an in-phase multi-stage amplifier circuit and an inverting multi-stage amplifier circuit, the variable gain The amplifying programmable amplitude modulator is connected to the sine wave generating device and the feedback adjustment device, the in-phase multi-stage amplifying circuit and the inverting multi-stage amplifying circuit are respectively connected to the variable gain amplifying programmable amplitude modulator, and the in-phase multi-stage amplifying circuit The circuit and the inverting multi-stage amplifying circuit are respectively connected to the first gating device, and the in-phase multi-stage amplifying circuit and the inverting multi-stage amplifying circuit are respectively connected to the control device.
The radio frequency transmission quadrupole power supply circuit according to claim 2, wherein the in-phase multi-stage amplifier circuit comprises a non-inverting amplifier, a first-stage power amplifier and a second-stage power amplifier, and the non-inverting amplifier is connected to a variable gain an amplification programmable amplitude modulator, the non-inverting amplifier is connected to the first-stage power amplifier, the first-stage power amplifier is connected to the second-stage power amplifier, and the second-stage power amplifier is connected to the first gating device, The non-inverting amplifier, the first-stage power amplifier and the second-stage power amplifier are respectively connected to the control device; and/or,

The inverting multi-stage amplifier circuit includes an inverting amplifier, a first-stage amplifier and a second-stage amplifier, the inverting amplifier is connected to a variable gain amplification program-controlled amplitude modulator, and the inverting amplifier is connected to the first-stage amplifier, The first-stage amplifier is connected to the second-stage amplifier, the second-stage amplifier is connected to the first gating device, and the inverting amplifier, the first-stage amplifier, and the second-stage amplifier are respectively connected the control device.
The radio frequency transmission quadrupole power supply circuit according to any one of claims 1-3, wherein the control device comprises a main controller, a power supply and current monitor, a gating controller and a medium and low voltage generator, The main controller is connected to the sine wave generating device, the feedback device is connected to the main controller, the power supply and current monitor, the gating controller and the medium and low voltage generator are respectively connected to the The main controller, the power supply and the current monitor are connected to the amplification device, the gating controller is connected to the first gating device and the second gating device, and the medium and low voltage generators are connected to each The secondary tap of the RF toroidal transformer is described.
The radio frequency transmission quadrupole power supply circuit according to claim 4, wherein the feedback adjustment device comprises a detection circuit, an amplitude monitor, a digital-to-analog controller and a proportional-integral regulator, and the detection circuit is connected to the a radio frequency transmission quadrupole, the detection circuit is connected to the proportional-integral regulator and the amplitude monitor, the amplitude monitor and the digital-analog controller are respectively connected to the control device, and the digital-analog control The proportional-integral regulator is connected to the proportional-integral regulator, and the proportional-integral regulator is connected to the amplifying device.
A method for controlling a radio frequency transmission quadrupole power supply circuit according to any one of claims 1-5, characterized in that, comprising:

Get the frequency set value;

control the first gating device and the second gating device to gating the corresponding radio frequency magnetic toroidal transformers according to the frequency setting value;

By adjusting the sine wave generating device and the feedback adjusting device, the resonant frequency at the minimum power consumption of the radio frequency transmission quadrupole power supply circuit is obtained.
The control method according to claim 6, wherein the radio frequency magnetic toroidal transformer comprises a low-frequency radio frequency magnetic toroidal transformer, a mid-frequency radio frequency magnetic toroidal transformer and a high-frequency radio frequency magnetic toroidal transformer, and the setting according to the frequency The step of controlling the first gating device and the second gating device to gating the corresponding radio frequency magnetic toroidal transformers includes:

Carry out comparative analysis according to the frequency setting value and the preset first frequency band range;

When the frequency setting value is within the preset first frequency band range, controlling the first gating device and the second gating device to gating the low-frequency radio frequency magnetic toroidal transformer;

When the frequency setting value is not within the preset first frequency band range, compare and analyze the frequency setting value and the preset second frequency band range, and the minimum threshold value of the preset second frequency band range is equal to the preset maximum threshold of the first frequency band;

When the frequency setting value is within the preset second frequency band range, controlling the first gating device and the second gating device to gating the mid-band radio frequency magnetic toroidal transformer;

When the frequency setting value is not within the preset second frequency band range, compare and analyze the frequency setting value and the preset third frequency band range, and the minimum threshold value of the preset third frequency band range is equal to the preset maximum threshold of the second frequency band range;

When the frequency setting value is within the preset third frequency band range, the first gating device and the second gating device are controlled to gating the high frequency band radio frequency magnetic toroidal transformer.
The control method according to claim 6, wherein the step of obtaining the resonant frequency of the radio frequency transmission quadrupole power supply circuit with minimum power consumption by adjusting the sine wave generating device and the feedback adjusting device comprises the following steps: :

Adjusting the sine wave generating device and the feedback adjusting device, and collecting the current value of the amplifying device in real time;

When the minimum current value of the amplifying device is obtained, the current frequency of the sine wave generating device is read, which is the resonant frequency at the minimum power consumption of the radio frequency transmission quadrupole power supply circuit.
A radio frequency transmission quadrupole power supply device, characterized in that it includes the radio frequency transmission quadrupole power supply circuit described in any one of claims 1-5, and the control device is used for the radio frequency transmission quadrupole power supply circuit according to any one of claims 6-8. The control method described above scans to obtain the resonant frequency with the minimum power consumption.
The radio frequency transmission quadrupole power supply device according to claim 9, further comprising a chassis, wherein the control device, the sine wave generating device and the feedback adjustment device are integrated on the same main control board, so The amplifying device, the first gating device, the second gating device and a plurality of radio frequency magnetic toroidal transformers are integrated and arranged on the same power amplifier board, and the main control board and the power amplifier board are pluggable and set. in the chassis.