CN116072504A - Mass spectrum analysis device based on quadrupole rods - Google Patents
Mass spectrum analysis device based on quadrupole rods Download PDFInfo
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- CN116072504A CN116072504A CN202211735430.9A CN202211735430A CN116072504A CN 116072504 A CN116072504 A CN 116072504A CN 202211735430 A CN202211735430 A CN 202211735430A CN 116072504 A CN116072504 A CN 116072504A
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- radio frequency
- mos tube
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- capacitor
- driving
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- 238000001819 mass spectrum Methods 0.000 title description 6
- 239000003990 capacitor Substances 0.000 claims abstract description 25
- 238000004949 mass spectrometry Methods 0.000 claims abstract description 14
- 238000000034 method Methods 0.000 claims description 14
- 230000003750 conditioning effect Effects 0.000 claims description 9
- 230000006698 induction Effects 0.000 claims description 9
- 238000001514 detection method Methods 0.000 claims description 5
- 230000003044 adaptive effect Effects 0.000 claims description 3
- 238000002955 isolation Methods 0.000 claims description 3
- 230000001360 synchronised effect Effects 0.000 claims description 3
- 230000007547 defect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 238000005173 quadrupole mass spectroscopy Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/022—Circuit arrangements, e.g. for generating deviation currents or voltages ; Components associated with high voltage supply
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/422—Two-dimensional RF ion traps
- H01J49/4225—Multipole linear ion traps, e.g. quadrupoles, hexapoles
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- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Electron Tubes For Measurement (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
The invention provides a mass spectrometry device based on quadrupole rods, wherein a radio-frequency coil is connected with two opposite pole rods in the quadrupole rods through a first wire, and is connected with the other two opposite pole rods through a second wire; the radio frequency voltage feedback circuit comprises: the first capacitor, the third MOS tube, the fourth MOS tube and the second capacitor are sequentially connected; the inductor is connected in series with the third capacitor; the two ends of the third capacitor are connected with the radio frequency driving circuit through wires; the self-adaptive MOS tube driver senses the radio frequency signals of the radio frequency coil by an antenna and outputs two paths of signals with opposite phases and equal frequency, wherein one path of signals are sent to the first MOS tube and the fourth MOS tube, and the other path of signals are sent to the second MOS tube and the third MOS tube. The invention has the advantages of accurate and stable radio frequency feedback signals and the like.
Description
Technical Field
The present invention relates to mass spectrometry, and in particular to a quadrupole-based mass spectrometry device.
Background
During quadrupole mass spectrometry (SIM or FULL SCAN), specific ions can stably pass through the quadrupole rods by changing direct current voltage (DC) and radio frequency voltage (RF), so that the aim of quality screening is fulfilled, and the accurate and stable radio frequency feedback voltage plays a key role in radio frequency voltage control and determines the accuracy and stability of an instrument quality shaft.
At present, the radio frequency voltage feedback circuit is generally designed by the following method: and after the high-voltage end of the radio frequency is connected with a pF-level capacitor, the high-voltage end of the radio frequency is subjected to half-wave or full-wave rectification and filtration through a diode to serve as a radio frequency voltage feedback signal. Because the diode has an I-V curve nonlinear region and the parasitic parameter of the diode is greatly changed due to temperature change, the radio frequency voltage feedback signal is inaccurate, and the accuracy and stability of mass spectrum mass numbers are affected. The device with wide requirements on certain mass ranges and high requirements on accuracy and stability of a mass axis is difficult to realize by using the topology, and usually, additional structures and circuits are required to be designed to ensure stable temperature and humidity, and fundamental problems are still not solved.
Disclosure of Invention
In order to solve the defects in the prior art, the invention provides a mass spectrometry device based on quadrupole rods.
The invention aims at realizing the following technical scheme:
the mass spectrometry device based on the quadrupole rods comprises the quadrupole rods and a radio frequency driving circuit, wherein the radio frequency driving circuit comprises radio frequency coils, the radio frequency coils are connected with two opposite pole rods in the quadrupole rods through a first wire, positive voltage is applied, and the radio frequency coils are connected with the other two opposite pole rods through a second wire, and negative voltage is applied; the radio frequency drive circuit further comprises a radio frequency voltage feedback circuit, the radio frequency voltage feedback circuit comprises:
the first conducting wire and the second conducting wire are sequentially connected with a first capacitor, a first MOS tube, a second MOS tube and a second capacitor, and the third MOS tube and the fourth MOS tube are connected in series and are connected in parallel with the first MOS tube and the second MOS tube which are connected in series; the inductor is connected in series with the third capacitor, the inductor is connected between the first MOS tube and the second MOS tube, the third capacitor is connected between the third MOS tube and the fourth MOS tube, and two ends of the third capacitor are sent to the radio frequency driving unit through wires;
the self-adaptive MOS tube driver is used for enabling an antenna to sense radio frequency signals of the radio frequency coil and outputting two signals with opposite phases and equal frequency, wherein one signal is sent to the first MOS tube and the fourth MOS tube, and the other signal is sent to the second MOS tube and the third MOS tube.
Compared with the prior art, the invention has the following beneficial effects:
1. the four low-voltage small-signal MOS tubes are used for replacing diodes, so that the advantages of no nonlinear region, insensitivity to temperature, large frequency application range (from tens of hertz to tens of megahertz), small on-resistance, high switching speed and the like of the MOS tubes are brought into play, and the accuracy and stability of rectification signals are ensured, so that the accuracy of a quality shaft can be greatly improved, and the advantages are obvious particularly in the process of scanning in a wide quality range, and meanwhile, the stability of the quality shaft is well ensured; the method can be suitable for signal feedback of higher RF voltage, namely, suitable for a higher mass range, such as suitable for LC-MS mass spectrum feedback topology, and the topology has wider application prospect;
by adopting the MOS tube scheme, the radio frequency feedback voltage can be minimized to 0V theoretically, so that the lower limit of mass spectrum mass number is widened, and even the lower limit is close to 0amu;
the MOS tube is adopted to flexibly select the feedback signal range, so that the applicability of the topology is greatly expanded;
the method has the advantages that a constant temperature and humidity circuit and related structures are not required to be designed, and the method is more advantageous in a portable mass spectrum scene;
2. in the diode scheme in the prior art, in a wide mass range, the accuracy of a mass axis is inevitably ensured by using multi-section fitting, and different scanning speeds correspond to various fitting parameters, so that larger mass deviation can be caused during organic analysis; the defects can be avoided in the MOS tube scheme, the fitting mode of the mass axis is simple, and the fitting of an equation is completed once;
3. the self-adaptive MOS tube driver automatically controls the on and off of the four MOS tubes by detecting the amplitude phase of the radio frequency signal, thereby achieving the rectification and filtering of the radio frequency voltage alternating current signal and finally obtaining an accurate and stable radio frequency feedback signal.
Drawings
The present disclosure will become more readily understood with reference to the accompanying drawings. As will be readily appreciated by those skilled in the art: the drawings are only for illustrating the technical scheme of the present invention and are not intended to limit the scope of the present invention. In the figure:
fig. 1 is a schematic structural diagram of a quadrupole-based mass spectrometry apparatus according to an embodiment of the present invention.
Detailed Description
Fig. 1 and the following description depict alternative embodiments of the invention to teach those skilled in the art how to make and reproduce the invention. For the purpose of explaining the technical solution of the present invention, some conventional aspects have been simplified or omitted. Those skilled in the art will appreciate variations or alternatives derived from these embodiments that fall within the scope of the invention. Those skilled in the art will appreciate that the features described below can be combined in various ways to form multiple variations of the invention. Thus, the invention is not limited to the following alternative embodiments, but only by the claims and their equivalents.
Example 1:
fig. 1 shows a schematic structural diagram of a quadrupole rod based mass spectrometry apparatus according to an embodiment of the present invention, as shown in fig. 1, the quadrupole rod based mass spectrometry apparatus includes:
the radio frequency driving circuit comprises radio frequency coils, wherein the radio frequency coils are connected with two opposite pole rods in the four pole rods through a first wire, positive voltage is applied, the radio frequency coils are connected with the other two opposite pole rods through a second wire, negative voltage is applied, and the radio frequency coils are all of the prior art in the field;
a radio frequency voltage feedback circuit, the radio frequency voltage feedback circuit comprising:
the first conducting wire and the second conducting wire are sequentially connected with a first capacitor, a first MOS tube, a second MOS tube and a second capacitor, and the third MOS tube and the fourth MOS tube are connected in series and are connected in parallel with the first MOS tube and the second MOS tube which are connected in series; the inductor is connected in series with the third capacitor, the inductor is connected between the first MOS tube and the second MOS tube, the third capacitor is connected between the third MOS tube and the fourth MOS tube, and two ends of the third capacitor are sent to the radio frequency driving unit through wires;
the self-adaptive MOS tube driver is used for enabling an antenna to sense radio frequency signals of the radio frequency coil and outputting two signals with opposite phases and equal frequency, wherein one signal is sent to the first MOS tube and the fourth MOS tube, and the other signal is sent to the second MOS tube and the third MOS tube.
In order to better output the two-way driving signal, further, the adaptive MOS transistor driver includes:
the signal conditioning unit is used for obtaining a radio frequency signal with the same frequency and different amplitudes with the input radio frequency signal;
the zero-crossing comparison unit is used for performing zero-crossing comparison on the radio frequency signal input into the comparator, and the rear end of the comparator outputs a square wave signal;
and the isolation driver unit is used for detecting input waveforms, performing MOS tube driving processing and performing MOS tube driving output.
The input waveform detection is to detect the height of the output square wave of the comparator; the MOS tube driving process is to perform driving process in the FPGA, wherein the driving process comprises dead zone control; the MOS tube driving output comprises two groups of driving signals and a power amplifying circuit.
The signal conditioning unit includes:
the radio frequency induction antenna is arranged on the secondary side of the radio frequency coil, and the fixing module is used for fixing the radio frequency induction antenna;
the radio frequency input signal protection module is used for limiting the voltage amplitude input to the operational amplifier;
the radio frequency induction signal conditioning module is used for realizing synchronous following of radio frequency signals.
Example 2:
application example of quadrupole-based mass spectrometry device according to embodiment 1 of the present invention.
In this application example, as shown in fig. 1, a quadrupole-based mass spectrometry apparatus includes:
the radio frequency driving circuit comprises radio frequency coils, wherein the radio frequency coils are connected with two opposite pole rods in the four pole rods through a first wire, positive voltage is applied, the radio frequency coils are connected with the other two opposite pole rods through a second wire, negative voltage is applied, and the radio frequency coils are all of the prior art in the field;
the radio frequency voltage feedback circuit comprises:
the first conducting wire and the second conducting wire are sequentially connected with a first capacitor, a first MOS tube, a second MOS tube and a second capacitor, and the third MOS tube and the fourth MOS tube are connected in series and are connected in parallel with the first MOS tube and the second MOS tube which are connected in series; the inductor is connected in series with the third capacitor, the inductor is connected between the first MOS tube and the second MOS tube, the third capacitor is connected between the third MOS tube and the fourth MOS tube, and two ends of the third capacitor are sent to the radio frequency driving unit through wires;
the adaptive MOS transistor driver comprises:
the signal conditioning unit is used for obtaining a radio frequency signal with the same frequency and different amplitudes with the input radio frequency signal; the signal conditioning unit includes: the radio frequency induction antenna is arranged on the secondary side of the radio frequency coil, and the fixing module is used for fixing the radio frequency induction antenna; the radio frequency input signal protection module is used for limiting the voltage amplitude input to the operational amplifier, and is usually composed of a plurality of high-speed TVS tubes; the radio frequency induction signal conditioning module is used for realizing synchronous following of radio frequency signals;
the zero-crossing comparison unit is used for performing zero-crossing comparison on the radio frequency signal input into the comparator, and the rear end of the comparator outputs a square wave signal;
the isolation driver unit is used for input waveform detection, MOS tube driving processing and MOS tube driving output, wherein the input waveform detection is to detect the output square wave of the comparator; the MOS tube driving process is to perform driving process in the FPGA, wherein the driving process comprises dead zone control; and the MOS tube driving output comprises two groups of driving signals and a power amplifying circuit, and finally, the MOS tube driving output has two signals with opposite phases and equal frequency, wherein one signal is sent to the first MOS tube and the fourth MOS tube, and the other signal is sent to the second MOS tube and the third MOS tube.
Claims (4)
1. The mass spectrometry device based on the quadrupole rods comprises the quadrupole rods and a radio frequency driving circuit, wherein the radio frequency driving circuit comprises radio frequency coils, the radio frequency coils are connected with two opposite pole rods in the quadrupole rods through a first wire, positive voltage is applied, and the radio frequency coils are connected with the other two opposite pole rods through a second wire, and negative voltage is applied; the radio frequency drive circuit is characterized by further comprising a radio frequency voltage feedback circuit, and the radio frequency voltage feedback circuit comprises:
the first conducting wire and the second conducting wire are sequentially connected with a first capacitor, a first MOS tube, a second MOS tube and a second capacitor, and the third MOS tube and the fourth MOS tube are connected in series and are connected in parallel with the first MOS tube and the second MOS tube which are connected in series; the inductor is connected in series with the third capacitor, the inductor is connected between the first MOS tube and the second MOS tube, the third capacitor is connected between the third MOS tube and the fourth MOS tube, and two ends of the third capacitor are sent to the radio frequency driving unit through wires;
the self-adaptive MOS tube driver is used for enabling an antenna to sense radio frequency signals of the radio frequency coil and outputting two signals with opposite phases and equal frequency, wherein one signal is sent to the first MOS tube and the fourth MOS tube, and the other signal is sent to the second MOS tube and the third MOS tube.
2. The quadrupole rod-based mass spectrometry apparatus of claim 1, wherein the adaptive MOS tube driver comprises:
the signal conditioning unit is used for obtaining a radio frequency signal with the same frequency and different amplitudes with the input radio frequency signal;
the zero-crossing comparison unit is used for performing zero-crossing comparison on the radio frequency signal input into the comparator, and the rear end of the comparator outputs a square wave signal;
and the isolation driver unit is used for detecting input waveforms, performing MOS tube driving processing and performing MOS tube driving output.
3. The quadrupole-based mass spectrometry apparatus of claim 2, wherein the input waveform detection is a high-low detection of an output square wave of the comparator; the MOS tube driving process is to perform driving process in the FPGA, wherein the driving process comprises dead zone control; the MOS tube driving output comprises two groups of driving signals and a power amplifying circuit.
4. The quadrupole-based mass spectrometry apparatus of claim 2, wherein the signal conditioning unit comprises:
the radio frequency induction antenna is arranged on the secondary side of the radio frequency coil, and the fixing module is used for fixing the radio frequency induction antenna;
the radio frequency input signal protection module is used for limiting the voltage amplitude input to the operational amplifier;
the radio frequency induction signal conditioning module is used for realizing synchronous following of radio frequency signals.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211735430.9A CN116072504A (en) | 2022-12-31 | 2022-12-31 | Mass spectrum analysis device based on quadrupole rods |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211735430.9A CN116072504A (en) | 2022-12-31 | 2022-12-31 | Mass spectrum analysis device based on quadrupole rods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116072504A true CN116072504A (en) | 2023-05-05 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211735430.9A Pending CN116072504A (en) | 2022-12-31 | 2022-12-31 | Mass spectrum analysis device based on quadrupole rods |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116072504A (en) |
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2022
- 2022-12-31 CN CN202211735430.9A patent/CN116072504A/en active Pending
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Effective date of registration: 20231127 Address after: 311305 no.2466-1 Keji Avenue, Qingshanhu street, Lin'an District, Hangzhou City, Zhejiang Province Applicant after: HANGZHOU PUYU TECHNOLOGY DEVELOPMENT Co.,Ltd. Applicant after: Hangzhou puju Medical Technology Co.,Ltd. Address before: 311305 no.2466-1 Keji Avenue, Qingshanhu street, Lin'an District, Hangzhou City, Zhejiang Province Applicant before: HANGZHOU PUYU TECHNOLOGY DEVELOPMENT Co.,Ltd. |
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