WO2022139739A2 - Composition having a ph value compatible with ideal ph value of skin and skin product in which said composition is applied - Google Patents

Composition having a ph value compatible with ideal ph value of skin and skin product in which said composition is applied Download PDF

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Publication number
WO2022139739A2
WO2022139739A2 PCT/TR2021/051254 TR2021051254W WO2022139739A2 WO 2022139739 A2 WO2022139739 A2 WO 2022139739A2 TR 2021051254 W TR2021051254 W TR 2021051254W WO 2022139739 A2 WO2022139739 A2 WO 2022139739A2
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Prior art keywords
skin
weight
composition
ratio
acid
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PCT/TR2021/051254
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French (fr)
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WO2022139739A3 (en
Inventor
Caner ACAR
Urun Kandemirer
Gulcin Almina FIDANLIK
Original Assignee
Eczacibasi Tuketim Urunleri Sanayi Ve Ticaret Anonim Sirketi
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Publication of WO2022139739A2 publication Critical patent/WO2022139739A2/en
Publication of WO2022139739A3 publication Critical patent/WO2022139739A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/005—Preparations for sensitive skin

Definitions

  • the subject of the invention relates to a composition enabling the skin to be cleansed by preserving the natural balance of the skin and without damaging the skin barrier and having a pH value compatible with the ideal pH value of the skin, wherein the number and concentrations of preservative agents employed in the products according to the state of the art are reduced owing to the reduction of the potential for the growth of microorganisms, and to a skin product in which said composition is applied.
  • the skin surface is the part of the body that is in continuous contact with the external environment and in interaction with numerous environmental factors and is thus exposed to numerous microbial agents in the environments contacted.
  • the skin is the part of the body that protects the internal organs from the external mechanical, chemical and biological effects by separating the same from the external environment, assists with the regulation of the body temperature and water balance and is capable of self-repair by performing the production of collagen and protein. Therefore, it is of importance to cleanse the skin by the use of skin products compatible with the pH value of the skin surface and without disrupting the skin barrier.
  • the need to clean our hands or face is today commonly satisfied still by the use of wet wipes.
  • the wet wipes are required to cleanse the skin without damaging the skin surface where they contact and by protecting the natural skin barrier and to provide the proper conditions of hygiene. Because of their practical use, the wet wipes are today frequently used in the restaurants, schools and even in hospitals, on the surfaces as well as on various body parts such as hands, face, etc. for the purposes of cleaning and hygiene. Because of their practical use, the mothers also make use of the wet wipes for cleansing the skin of their babies.
  • the wet wipes being used are expected to cleanse the skin surface and achieve the hygienic conditions while at the same time preserving the skin barrier and the moisture balance of the skin and having a pH value suitable for the protection of the skin health.
  • the microorganisms such as yeast fungi, etc. are known to have a high growth potential on the skin in an environment of high pH (6-6.5).
  • an environment of low pH assists in the reinforcement of the natural barrier layer of the skin by supporting the production of ceramide, one of the basic constituents of the skin. Therefore, the pH of the skin is desired to lie in the range of 4-4.5.
  • the pH value of the wet wipes intended for skin cleansing has become a need and has become even more widespread especially in the periods of disease and epidemics, to be compatible with the pH value of the skin.
  • the pH value of the wet wipes used according to the state of the art is in the range of 5.5-6, which fails to satisfy the mentioned need, and the frequent use of the wet wipes with such pH range especially in the presence of an epidemic or disease leads to the skin problems.
  • the wet wipes are obtained by way of impregnation of the nonwoven fabrics with a solution having generally high water content.
  • a nonwoven fabric is subjected to treatment with a solution with high water content, more than one preservative agent (hexamidine diisethionate, methylisothiazolinone, benzisothiazolinone, imidazolidinyl urea, diazolidinyl urea, polyaminopropyl biguanide, DMDMH, etc.) with the possibility of providing action against different microorganisms (bacteria, mould, yeast) are added to the wet wipe formulations usually at high ratios such that no microbiological growth occurs.
  • preservative agent hexamidine diisethionate, methylisothiazolinone, benzisothiazolinone, imidazolidinyl urea, diazolidinyl urea, polyaminopropyl biguanide, DMDMH, etc.
  • Another problem encountered in the state of the art is the necessity to use greater number preservative agents at higher concentrations in the products having a high pH value (5.5-6) in order to protect such products microbiologically.
  • a nonwoven fabric is treated with a solution/composition, differences are observed in the pH values of the finished products due to the components transferred from the fabric to the solution. Accordingly, stabilizing the pH values of the employed solutions/compositions is a further problem encountered in the state of the art that needs to be solved.
  • the invention is aimed to develop a skin care product with a lower potential for the growth of microorganisms owing to having a lower and more stable pH value as compared to the existing products, in an effort to provide a solution for the mentioned problems.
  • the potential for the growth of microorganisms will be reduced in the product owing to the low pH value, it will be possible to cleanse the skin with a skin product compatible with the pH value of the skin, and further, the use of a smaller number of preservatives at lower concentrations will be possible as a result of the low pH value.
  • compositions comprising a smaller number of preservative agents at lower concentrations and having a pH value compatible with the pH value of the skin and a skin product in which said composition is applied have been developed within the scope of the invention.
  • Table 1 Minimum inhibitory concentration value of pentylene glycol in the pH environment of the composition developed within the scope of the invention and minimum inhibitory concentration value of pentylene glycol stated in the literature
  • An object of the invention is to develop a composition having a pH value compatible with the pH value of the skin.
  • Another object of the invention is to develop a skin product, which is to be used in cleansing the skin surface and which is to enable the development of the hygienic conditions ideal for the skin by preserving the skin barrier and by having a pH value compatible with the pH value of the skin.
  • Another object of the invention is to develop a skin care product wherein the potential for the growth of microorganisms is reduced owing to a pH value of about 3-4.5 and the conditions favorable in terms of hygiene are provided.
  • Another object of the invention is to develop a wet wipe as the skin care product.
  • the subject of the invention relates to a composition enabling the skin to be cleansed by preserving the natural balance of the skin and without damaging the skin barrier and having a pH value compatible with the ideal pH value of the skin, wherein the number and concentrations of preservative agents employed in the products according to the state of the art are reduced owing to the reduction of the potential for the growth of microorganisms, and to a skin product in which said composition is applied.
  • the skin products currently in use generally contain more than one preservative agent in high concentrations in order to provide microbiological protection for said products.
  • These preservatives used in the skin products cause the irritation of the skin and increased water loss from the skin due to the disruption of the skin barrier.
  • the disruption of the moisture balance of the skin and of the barrier layer that protects the skin provides a favorable environment for sheltering the components that irritate the skin and the pathogenic microorganisms desired to be removed from the skin surface. This leads to the development of allergic reactions in the skin.
  • a low pH assists in the reinforcement of the natural barrier layer of the skin by supporting the production of ceramide, one of the basic constituents of the skin. It is not possible to keep the pH values of the products currently in use at such acidity levels. When the pH value of the finished products fails to provide sufficient acidity, it becomes necessary to employ higher ratios of preservative agents in order to achieve a microbiologically effective protection. In that case, the natural balance of the skin becomes disrupted, and instead of providing the hygienically appropriate conditions, the skin is rendered an environment favorable as a host for the microorganisms.
  • compositions having a pH value compatible with the pH of the skin wherein the pH variation is minimized and a skin product in which said composition is applied have been developed within the scope of the invention.
  • composition developed within the scope of the invention comprises water, at least one preservative agent with increased activity against the microorganisms in a low pH range compatible with the pH value of the skin, preferably in the pH range of 3-4.5, and at least one pH-regulating agent that enables the ambient pH to be stable.
  • composition according to the invention preferably comprises a buffer pair containing at least one acid and the conjugate base of the acid as the pH-regulating agent.
  • pentylene glycol is preferably used as the preservative agent. It was found out that the activity of pentylene glycol increases with decreasing ambient pH value (3-4.5). Based on the results of the minimum inhibitory concentration (MIC) test conducted, it was determined that pentylene glycol was effective against different microorganisms at these pH values.
  • the minimum inhibitory concentration (MIC) of pentylene glycol that is stated in the literature to be effective against the microorganisms is higher than the ratio used within the scope of the invention.
  • the minimum inhibitory concentrations stated in the literature and the concentration of pentylene glycol required to be used in an environment of low pH value developed within the scope of the invention are shown in Table 1 below.
  • Table 1 Minimum inhibitory concentration value of pentylene glycol in the pH environment of the composition developed within the scope of the invention and minimum inhibitory concentration value of pentylene glycol stated in the literature
  • composition developed within the scope of the invention comprises 85-91% by weight water, 2-4% by weight at least one pH-regulating agent and 1-5% by weight at least one preservative agent.
  • the use of at least one of citric acid-sodium citrate conjugated acid-base pair, lactic acid-sodium lactate conjugated acid-base pair and acetic acid-sodium acetate conjugated acid-base pair is preferred as the pH-regulating agent.
  • At least one conjugated acid-base pair containing 1-2% by weight at least one acid and 1-2% by weight conjugate base of the acid used is employed as the pH-regulating agent.
  • a preferred embodiment of the invention comprises pentylene glycol as the preservative agent and citric acid-sodium citrate conjugated acid-base pair as the pH-regulating agent.
  • Another preferred embodiment of the invention comprises pentylene glycol as the preservative agent and lactic acid-sodium lactate conjugated acid-base pair as the pH- regulating agent.
  • Another preferred embodiment of the invention comprises pentylene glycol as the preservative agent and acetic acid-sodium acetate conjugated acid-base pair as the pH- regulating agent.
  • pentylene glycol is used at a ratio of 1-1.5% by weight as the preservative agent.
  • pentylene glycol is used at a ratio of 1.5-2% by weight as the preservative agent. In a preferred embodiment of the composition developed within the scope of the invention, pentylene glycol is used at a ratio of 2-2.5% by weight as the preservative agent.
  • pentylene glycol is used at a ratio of 2.5-3% by weight as the preservative agent.
  • the subject of the invention also relates to a skin product in which the composition according to the invention is applied.
  • the skin product developed within the scope of the invention is preferably a wet wipe.
  • the skin product according to the invention is obtained by way of application of the composition according to the invention to a nonwoven fabric. After the wet wipe compositions are prepared, the nonwoven fabrics are subjected to treatment with the compositions in order to obtain the skin product.
  • the weight of one piece of dry tissue is determined by performing calculations based on a nonwoven fabric with known dimensions (width and length) and weight (g/m2). How much composition is to be transferred to one piece of dry tissue is determined according to the wetting factor and the skin product is obtained by impregnating the dry product with the composition according to the invention under the appropriate conditions.

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Abstract

The subject of the invention relates to a composition enabling the skin to be cleansed by preserving the natural balance of the skin and without damaging the skin barrier and having a pH value compatible with the ideal pH value of the skin, wherein the number and concentrations of preservative agents employed in the products according to the state of the art are reduced owing to the reduction of the potential for the growth of microorganisms, and to a skin product in which said composition is applied. The composition developed within the scope of the invention comprises 85-91% by weight water, 2-4% by weight at least one pH-regulating agent and 1-5% by weight at least one preservative agent.

Description

COMPOSITION HAVING A pH VALUE COMPATIBLE WITH IDEAL pH VALUE OF SKIN AND SKIN PRODUCT IN WHICH SAID COMPOSITION IS APPLIED
Subject of the Invention
The subject of the invention relates to a composition enabling the skin to be cleansed by preserving the natural balance of the skin and without damaging the skin barrier and having a pH value compatible with the ideal pH value of the skin, wherein the number and concentrations of preservative agents employed in the products according to the state of the art are reduced owing to the reduction of the potential for the growth of microorganisms, and to a skin product in which said composition is applied.
State of the Art
The skin surface is the part of the body that is in continuous contact with the external environment and in interaction with numerous environmental factors and is thus exposed to numerous microbial agents in the environments contacted. Besides, the skin is the part of the body that protects the internal organs from the external mechanical, chemical and biological effects by separating the same from the external environment, assists with the regulation of the body temperature and water balance and is capable of self-repair by performing the production of collagen and protein. Therefore, it is of importance to cleanse the skin by the use of skin products compatible with the pH value of the skin surface and without disrupting the skin barrier.
In the ambiences such as travel ambience where to make use of water is not immediately possible or in the ambiences such as public transport where the hygienic conditions are not appropriate, the need to clean our hands or face is today commonly satisfied still by the use of wet wipes. The wet wipes, the use of which has become quite widespread, are required to cleanse the skin without damaging the skin surface where they contact and by protecting the natural skin barrier and to provide the proper conditions of hygiene. Because of their practical use, the wet wipes are today frequently used in the restaurants, schools and even in hospitals, on the surfaces as well as on various body parts such as hands, face, etc. for the purposes of cleaning and hygiene. Because of their practical use, the mothers also make use of the wet wipes for cleansing the skin of their babies.
The wet wipes being used are expected to cleanse the skin surface and achieve the hygienic conditions while at the same time preserving the skin barrier and the moisture balance of the skin and having a pH value suitable for the protection of the skin health. The microorganisms such as yeast fungi, etc. are known to have a high growth potential on the skin in an environment of high pH (6-6.5). On the other hand, an environment of low pH assists in the reinforcement of the natural barrier layer of the skin by supporting the production of ceramide, one of the basic constituents of the skin. Therefore, the pH of the skin is desired to lie in the range of 4-4.5. Likewise, it has become a significant necessity for the pH value of the wet wipes intended for skin cleansing, the use of which has become a need and has become even more widespread especially in the periods of disease and epidemics, to be compatible with the pH value of the skin. In this way, it would be possible to cleanse the skin without the development of skin problems such as infection, irritation and rash, etc. by preventing the growth of the yeast fungi such as Candida Albicans and other microorganisms and without increasing the pH value of the skin. However, the pH value of the wet wipes used according to the state of the art is in the range of 5.5-6, which fails to satisfy the mentioned need, and the frequent use of the wet wipes with such pH range especially in the presence of an epidemic or disease leads to the skin problems.
The wet wipes are obtained by way of impregnation of the nonwoven fabrics with a solution having generally high water content. When a nonwoven fabric is subjected to treatment with a solution with high water content, more than one preservative agent (hexamidine diisethionate, methylisothiazolinone, benzisothiazolinone, imidazolidinyl urea, diazolidinyl urea, polyaminopropyl biguanide, DMDMH, etc.) with the possibility of providing action against different microorganisms (bacteria, mould, yeast) are added to the wet wipe formulations usually at high ratios such that no microbiological growth occurs. However, when the products according to the state of the art are used, the skin irritation occurs and the skin problems on the skin surface, such as rash, etc., emerge especially in the babies having a thinner and more sensitive skin than the adult skin, depending on the concentrations and types of the preservatives such products contain.
Another problem encountered in the state of the art is the necessity to use greater number preservative agents at higher concentrations in the products having a high pH value (5.5-6) in order to protect such products microbiologically. Moreover, when a nonwoven fabric is treated with a solution/composition, differences are observed in the pH values of the finished products due to the components transferred from the fabric to the solution. Accordingly, stabilizing the pH values of the employed solutions/compositions is a further problem encountered in the state of the art that needs to be solved.
Within the scope of the invention, it is aimed to develop a skin care product with a lower potential for the growth of microorganisms owing to having a lower and more stable pH value as compared to the existing products, in an effort to provide a solution for the mentioned problems. By this means, the potential for the growth of microorganisms will be reduced in the product owing to the low pH value, it will be possible to cleanse the skin with a skin product compatible with the pH value of the skin, and further, the use of a smaller number of preservatives at lower concentrations will be possible as a result of the low pH value.
In order to satisfy the mentioned need and resolve the above-mentioned problems of the state of the art, a composition comprising a smaller number of preservative agents at lower concentrations and having a pH value compatible with the pH value of the skin and a skin product in which said composition is applied have been developed within the scope of the invention.
Description of the Tables
Table 1: Minimum inhibitory concentration value of pentylene glycol in the pH environment of the composition developed within the scope of the invention and minimum inhibitory concentration value of pentylene glycol stated in the literature
Object of the Invention
An object of the invention is to develop a composition having a pH value compatible with the pH value of the skin.
Another object of the invention is to develop a skin product, which is to be used in cleansing the skin surface and which is to enable the development of the hygienic conditions ideal for the skin by preserving the skin barrier and by having a pH value compatible with the pH value of the skin.
Another object of the invention is to develop a skin care product wherein the potential for the growth of microorganisms is reduced owing to a pH value of about 3-4.5 and the conditions favorable in terms of hygiene are provided.
Another object of the invention is to develop a wet wipe as the skin care product.
Description of the Invention
The subject of the invention relates to a composition enabling the skin to be cleansed by preserving the natural balance of the skin and without damaging the skin barrier and having a pH value compatible with the ideal pH value of the skin, wherein the number and concentrations of preservative agents employed in the products according to the state of the art are reduced owing to the reduction of the potential for the growth of microorganisms, and to a skin product in which said composition is applied.
The skin products currently in use generally contain more than one preservative agent in high concentrations in order to provide microbiological protection for said products. These preservatives used in the skin products cause the irritation of the skin and increased water loss from the skin due to the disruption of the skin barrier. The disruption of the moisture balance of the skin and of the barrier layer that protects the skin provides a favorable environment for sheltering the components that irritate the skin and the pathogenic microorganisms desired to be removed from the skin surface. This leads to the development of allergic reactions in the skin.
A low pH assists in the reinforcement of the natural barrier layer of the skin by supporting the production of ceramide, one of the basic constituents of the skin. It is not possible to keep the pH values of the products currently in use at such acidity levels. When the pH value of the finished products fails to provide sufficient acidity, it becomes necessary to employ higher ratios of preservative agents in order to achieve a microbiologically effective protection. In that case, the natural balance of the skin becomes disrupted, and instead of providing the hygienically appropriate conditions, the skin is rendered an environment favorable as a host for the microorganisms. In addition, when a nonwoven fabric is treated with a solution/composition in order to obtain the skin products, the differences are observed in the pH values of the finished products due to the components transferred from the fabric to the solution. Accordingly, it is necessary to minimize the pH variation in the composition.
In order to provide a solution for the mentioned problems, a composition having a pH value compatible with the pH of the skin wherein the pH variation is minimized and a skin product in which said composition is applied have been developed within the scope of the invention.
The composition developed within the scope of the invention comprises water, at least one preservative agent with increased activity against the microorganisms in a low pH range compatible with the pH value of the skin, preferably in the pH range of 3-4.5, and at least one pH-regulating agent that enables the ambient pH to be stable.
The composition according to the invention preferably comprises a buffer pair containing at least one acid and the conjugate base of the acid as the pH-regulating agent.
Within the scope of the invention, pentylene glycol is preferably used as the preservative agent. It was found out that the activity of pentylene glycol increases with decreasing ambient pH value (3-4.5). Based on the results of the minimum inhibitory concentration (MIC) test conducted, it was determined that pentylene glycol was effective against different microorganisms at these pH values. The minimum inhibitory concentration (MIC) of pentylene glycol that is stated in the literature to be effective against the microorganisms is higher than the ratio used within the scope of the invention. The minimum inhibitory concentrations stated in the literature and the concentration of pentylene glycol required to be used in an environment of low pH value developed within the scope of the invention are shown in Table 1 below.
Table 1: Minimum inhibitory concentration value of pentylene glycol in the pH environment of the composition developed within the scope of the invention and minimum inhibitory concentration value of pentylene glycol stated in the literature
Figure imgf000006_0001
The composition developed within the scope of the invention comprises 85-91% by weight water, 2-4% by weight at least one pH-regulating agent and 1-5% by weight at least one preservative agent.
Within the scope of the invention, the use of at least one of citric acid-sodium citrate conjugated acid-base pair, lactic acid-sodium lactate conjugated acid-base pair and acetic acid-sodium acetate conjugated acid-base pair is preferred as the pH-regulating agent.
In a preferred embodiment of the invention, at least one conjugated acid-base pair containing 1-2% by weight at least one acid and 1-2% by weight conjugate base of the acid used is employed as the pH-regulating agent.
A preferred embodiment of the invention comprises pentylene glycol as the preservative agent and citric acid-sodium citrate conjugated acid-base pair as the pH-regulating agent.
Another preferred embodiment of the invention comprises pentylene glycol as the preservative agent and lactic acid-sodium lactate conjugated acid-base pair as the pH- regulating agent.
Another preferred embodiment of the invention comprises pentylene glycol as the preservative agent and acetic acid-sodium acetate conjugated acid-base pair as the pH- regulating agent.
In a preferred embodiment of the composition developed within the scope of the invention, pentylene glycol is used at a ratio of 1-1.5% by weight as the preservative agent.
In a preferred embodiment of the composition developed within the scope of the invention, pentylene glycol is used at a ratio of 1.5-2% by weight as the preservative agent. In a preferred embodiment of the composition developed within the scope of the invention, pentylene glycol is used at a ratio of 2-2.5% by weight as the preservative agent.
In a preferred embodiment of the composition developed within the scope of the invention, pentylene glycol is used at a ratio of 2.5-3% by weight as the preservative agent.
The subject of the invention also relates to a skin product in which the composition according to the invention is applied. The skin product developed within the scope of the invention is preferably a wet wipe. The skin product according to the invention is obtained by way of application of the composition according to the invention to a nonwoven fabric. After the wet wipe compositions are prepared, the nonwoven fabrics are subjected to treatment with the compositions in order to obtain the skin product. The weight of one piece of dry tissue is determined by performing calculations based on a nonwoven fabric with known dimensions (width and length) and weight (g/m2). How much composition is to be transferred to one piece of dry tissue is determined according to the wetting factor and the skin product is obtained by impregnating the dry product with the composition according to the invention under the appropriate conditions.
Owing to the composition developed within the scope of the invention and the skin product in which said composition is applied, it is made possible to cleanse the skin by preserving the moisture balance of the skin and the skin barrier and without increasing the pH value of the skin, as a result of the pH value of the composition being stable and compatible with the pH of the skin, and further, the adverse effects of the existing products on the skin health are eliminated since the product according to the invention does not contain any additional preservative agent, owing to said product's content of preservative agent with increased activity against the microorganisms at low pH values (3-4.5).

Claims

1. A composition having a pH value that is stable and compatible with the pH of the skin characterized in that the composition comprises
• water,
• at least one pH-regulating agent containing a pair formed by at least one acid and the conjugate base of the acid such that the pH value is stable in the range of 3-4.5, and
• at least one preservative agent with activity against the microorganisms in said pH range of 3-4.5.
2. A composition according to Claim 1 characterized in that said preservative agent is pentylene glycol.
3. Composition according to Claim 1 or Claim 2 characterized in that the composition comprises said preservative agent at a ratio of 1-5% by weight.
4. Composition according to Claim 1 or Claim 2 characterized in that the composition comprises said preservative agent at a ratio of 1-1.5% by weight.
5. Composition according to Claim 1 or Claim 2 characterized in that the composition comprises said preservative agent at a ratio of 1.5-2% by weight.
6. Composition according to Claim 1 or Claim 2 characterized in that the composition comprises said preservative agent at a ratio of 2-2.5% by weight.
7. Composition according to Claim 1 or Claim 2 characterized in that the composition comprises said preservative agent at a ratio of 2.5-3% by weight.
8. Composition according to any one of preceding claims characterized in that the composition comprises said pH-regulating agent at a ratio of 2-4% by weight.
9. Composition according to Claim 1 or Claim 8 characterized in that the composition comprises as said pH-regulating agent at least one conjugated acid-base pair containing 1- 2% by weight at least one acid and 1-2% by weight conjugate base of the acid used.
10. Composition according to Claim 1 or Claim 9 characterized in that said pH-regulating agent is at least one of citric acid-sodium citrate conjugated acid-base pair, lactic acid- sodium lactate conjugated acid-base pair and acetic acid-sodium acetate conjugated acidbase pair.
11. Composition according to claim 1 characterized in that the composition comprises
• 85-91% by weight water,
• at least one acid at a ratio of 1-2% by weight and conjugate base of the acid at a ratio of 1-2% by weight as the pH-regulating agent, and
7 pentylene glycol as the preservative agent.
12. Composition according to Claim 11 characterized in that said acid at a ratio of 1-2% by weight is citric acid and said base used at a ratio of 1-2% by weight is sodium citrate.
13. Composition according to Claim 11 characterized in that said acid at a ratio of 1-2% by weight is lactic acid and said base used at a ratio of 1-2% by weight is sodium lactate.
14. Composition according to Claim 11 characterized in that said acid at a ratio of 1-2% by weight is acetic acid and said base used at a ratio of 1-2% by weight is sodium acetate.
15. A composition according to any one of Claims 11-14 characterized in that the composition comprises said preservative agent at a ratio of 1-1.5% by weight.
16. A composition according to any one of Claims 11-14 characterized in that the composition comprises said preservative agent at a ratio of 1.5-2% by weight.
17. A composition according to any one of Claims 11-14 characterized in that the composition comprises said preservative agent at a ratio of 2-2.5% by weight.
18. A composition according to any one of Claims 11-14 characterized in that the composition comprises said preservative agent at a ratio of 2.5-3% by weight.
19. A skin product characterized in that the skin product comprises a composition according to any one of the preceding claims.
20. A skin product according to Claim 19 characterized in that the skin product is a wet wipe.
21. A skin product according to Claim 20 characterized in that the skin product has a pH value in the range of 3-4.5.
8
PCT/TR2021/051254 2020-12-21 2021-11-22 Composition having a ph value compatible with ideal ph value of skin and skin product in which said composition is applied WO2022139739A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2020/20998A TR202020998A2 (en) 2020-12-21 2020-12-21 A COMPOSITION WITH A pH VALUE COMPATIBLE WITH THE IDEAL SKIN pH VALUE AND A SKIN PRODUCT WHICH IS APPLIED TO THIS COMPOSITION
TR2020/20998 2020-12-21

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WO2022139739A2 true WO2022139739A2 (en) 2022-06-30
WO2022139739A3 WO2022139739A3 (en) 2022-08-11

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WO (1) WO2022139739A2 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6828136B2 (en) * 2016-10-11 2021-02-10 シムライズ アーゲー Antibacterial composition
KR102026810B1 (en) * 2017-12-12 2019-09-30 주식회사 크로파세 A preservative for skin external application, and a cosmetic composition and a pharmaceutical composition comprising the same
CN108014032A (en) * 2018-01-02 2018-05-11 深圳市芭格美生物科技有限公司 A kind of hip pad wet tissue and preparation method thereof

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