WO2022135965A1 - Membrane for a microfluidic cartridge with recesses for a microchannel or an electric component, and method for producing a membrane and a cartridge with a membrane - Google Patents
Membrane for a microfluidic cartridge with recesses for a microchannel or an electric component, and method for producing a membrane and a cartridge with a membrane Download PDFInfo
- Publication number
- WO2022135965A1 WO2022135965A1 PCT/EP2021/085122 EP2021085122W WO2022135965A1 WO 2022135965 A1 WO2022135965 A1 WO 2022135965A1 EP 2021085122 W EP2021085122 W EP 2021085122W WO 2022135965 A1 WO2022135965 A1 WO 2022135965A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- membrane
- cartridge
- recesses
- substrate
- electrical component
- Prior art date
Links
- 239000012528 membrane Substances 0.000 title claims abstract description 116
- 238000004519 manufacturing process Methods 0.000 title claims description 8
- 238000000034 method Methods 0.000 claims abstract description 16
- 238000001746 injection moulding Methods 0.000 claims abstract description 14
- 239000000758 substrate Substances 0.000 claims description 32
- 238000004049 embossing Methods 0.000 claims description 26
- 238000010438 heat treatment Methods 0.000 claims description 21
- 238000001816 cooling Methods 0.000 claims description 11
- -1 polydimethylsiloxane Polymers 0.000 claims description 8
- 229920002725 thermoplastic elastomer Polymers 0.000 claims description 7
- 229920003023 plastic Polymers 0.000 claims description 6
- 238000003466 welding Methods 0.000 claims description 5
- 239000004793 Polystyrene Substances 0.000 claims description 4
- 239000004033 plastic Substances 0.000 claims description 4
- 239000011116 polymethylpentene Substances 0.000 claims description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 3
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 3
- 229920002285 poly(styrene-co-acrylonitrile) Polymers 0.000 claims description 3
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 3
- 229920002223 polystyrene Polymers 0.000 claims description 3
- 229920001577 copolymer Polymers 0.000 claims description 2
- 229920000306 polymethylpentene Polymers 0.000 claims 1
- 238000004458 analytical method Methods 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- 239000011888 foil Substances 0.000 description 5
- 239000004698 Polyethylene Substances 0.000 description 4
- 239000004743 Polypropylene Substances 0.000 description 4
- 239000004433 Thermoplastic polyurethane Substances 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 229920001971 elastomer Polymers 0.000 description 4
- 239000000806 elastomer Substances 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- 229920000139 polyethylene terephthalate Polymers 0.000 description 4
- 239000005020 polyethylene terephthalate Substances 0.000 description 4
- 229920001155 polypropylene Polymers 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 229920002803 thermoplastic polyurethane Polymers 0.000 description 4
- 238000009434 installation Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229920001721 polyimide Polymers 0.000 description 3
- 229920002635 polyurethane Polymers 0.000 description 3
- 239000004814 polyurethane Substances 0.000 description 3
- 239000004642 Polyimide Substances 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000000748 compression moulding Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 239000004417 polycarbonate Substances 0.000 description 2
- 229920000515 polycarbonate Polymers 0.000 description 2
- 238000003752 polymerase chain reaction Methods 0.000 description 2
- 229920000098 polyolefin Polymers 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 238000002032 lab-on-a-chip Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000002493 microarray Methods 0.000 description 1
- 238000013021 overheating Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000005245 sintering Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
- B01L2300/123—Flexible; Elastomeric
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
Definitions
- Analysis cartridges for lab-on-chip diagnostic systems are often constructed with structured carrier plates made of transparent plastic, which are usually connected to an elastic membrane using a laser welding process. While analysis components such as reagent bars, beads and microarrays can be integrated into specially shaped chambers of the carrier plates, the membrane is used to implement pump functions and to seal between the carrier plates.
- the membrane can be designed in particular as an elastomer membrane, for example based on thermoplastic polyurethane elastomer (TPU) produced as an extruded film and then punched out to fit.
- TPU thermoplastic polyurethane elastomer
- the membrane can have a hardness of between 68 and 94 on the Shore A scale.
- Lab-on-a-chip cartridges are also used for automated execution of a polymerase chain reaction (PCR), for example to test for pathogens, for example as a Sars-CoV2-PCR test.
- PCR polymerase chain reaction
- one or more chambers of the cartridge must be heated to temperatures close to 100 °C, using external heating element blocks.
- the invention relates to a membrane for a microfluidic cartridge and a cartridge with such a membrane.
- the membrane has one or more recesses for a microchannel or an electrical component.
- the electrical component can in particular be a sensor element or a heating element and/or cooling element.
- a membrane can preferably be understood to mean an elastic membrane, in particular a membrane made of plastic, for example an elastomer membrane.
- the membrane preferably comprises a thermoplastic elastomer, for example a thermoplastic elastomer based on polyurethane (TPU) or based on polystyrene (TPS).
- TPU polyurethane
- TPS polystyrene
- the membrane can have a thickness between 100 and 500 micrometers, for example.
- a cartridge can be understood in particular as a microfluidic cartridge, based for example on a cartridge described in DE 10 2016 222 075 A1 or DE 10 2016 222 072 A1, also referred to as an analysis cartridge.
- Such cartridges are often designed as passive components and are operated by a processing unit for processing the sample contained in the cartridge.
- the cartridges can be designed in the form of a layered structure.
- the cartridge preferably comprises at least two substrates between which the membrane is arranged.
- the two substrates can be made of transparent polycarbonate, for example.
- fluidic substrate is usually equipped with channels and chambers for the fluidic transport of a sample taken, for example a body fluid, and other reagents, while the other substrate (“pneumatic substrate”) has channels and chambers for a mechanical and/or has pneumatic control of the membrane.
- the membrane works thereby as part of diaphragm pumps or diaphragm valves for fluidic control in the fluidic substrate.
- a recess is to be understood in particular as a space that is kept free in the membrane and is not filled with membrane material.
- the recess is a recess in the membrane.
- This recess preferably includes the electrical component and/or the microchannel or is designed in the form of a microchannel.
- the recess preferably has dimensions in the micrometer to millimeter range.
- the membrane can have at least one sensor element, at least one heating element and/or at least one microchannel.
- a microchannel is to be understood in particular as a channel for conveying fluid with cross sections in the micrometer range.
- the microchannel has a width between 1 and 5000 microns, preferably between 1 and 1000 microns, most preferably between 1 and 500 microns.
- the electrical component can in particular be a sensor element or a heating element and/or cooling element.
- a heating element and/or cooling element can be understood to mean, for example, a Peltier element, resistance heating, for example a heating wire, or in particular a printable heating element.
- the heating and/or cooling element is preferably an electrical component or sensor element that can be bent partially or in sections, for example an at least partially bendable Peltier element, a flexible, printable PTC heating element or a printable heating element, as for example in Offenlegungsschrift DE 10 2018 002 686 A1.
- a sensor element means in particular a part of a sensor, for example a part of a temperature sensor, a force measurement sensor, a strain measurement sensor, a pressure sensor or a gas sensor.
- a measuring head of such a sensor with a thickness of less than 300 micrometers is accommodated in a recess in the membrane.
- the electrical component can be an electrical supply line or a contact of the sensor or of the heating or cooling element. In the case of contact of the sensor, the contact for contacting with the medium to be sensed.
- the contact is part of a temperature sensor.
- the invention advantageously makes it possible for the electrical components to interact directly with chambers of a substrate adjoining the membrane, in particular to directly heat or cool or sense adjoining chambers.
- the use of larger elements with greater required power outside the cartridge can thus advantageously be dispensed with, which saves energy and installation space and reduces sources of error, and also targeted heating or cooling can be improved.
- more than one cartridge can be accommodated in an analysis device for accommodating the cartridges at the same time and/or alternatively the analysis devices can be made more compact.
- the substrates of the cartridge no longer have to withstand the "overheating" temperatures of external heating elements and are therefore made of inexpensive plastics such as polystyrene (PS), styrene-acrylonitrile copolymer (SAN), polymethylpentene (PMP), cycloolefin Copolymer (COP, COC), polymethyl methacrylate (PMMA) or polydimethylsiloxane (PDMS) can be produced.
- PS polystyrene
- SAN styrene-acrylonitrile copolymer
- PMP polymethylpentene
- COP cycloolefin Copolymer
- PMMA polymethyl methacrylate
- PDMS polydimethylsiloxane
- the invention enables fluid to be conveyed between the membrane and an adjacent substrate.
- At least one recess is designed such that the electrical component or preferably the entire sensor is flush with a surface of the membrane in the Membrane can be arranged.
- the membrane according to the invention can have a flat surface despite the inclusion of an electrical component.
- the electrical component thus closes flush or level with the surface of the membrane.
- the electrical components and microchannels accommodated in the recesses are advantageously securely enclosed.
- the membrane is welded to particularly brittle substrates, for example carrier plates, it is advantageous that no stresses occur in the material of the often amorphous substrates due to the flat surface and the resulting weld seams remain tight.
- At least one recess is open on a surface of the membrane.
- the substrate also has an open recess (which can represent a chamber in a fluidic network in the substrate), which adjoins the recess of the membrane when the substrate is arranged on the membrane, so that there is no barrier between the two recesses.
- This is particularly advantageous when fluid is to be conveyed between the two recesses or when a fluid is in the recess of the substrate is to be sensed by an electrical component in the recess of the membrane.
- At least one of the recesses has an undercut, also called an undercut.
- An undercut can be understood in particular as an incision that is inclined relative to a surface of the membrane, in particular an incision for a recess in the membrane, the incision forming a wall of the recess that widens in relation to the surface. If the recess is delimited by two undercuts, the recess has a width that decreases in the direction of a surface of the membrane. This has the advantage that an electrical component accommodated in the recess is fixed in the membrane by the inclined surface of the undercut and thus advantageously cannot easily fall out of the recess. In the case of a microchannel, such undercuts have the advantage that the microchannel tapers in the direction of the opening of the recess and thus there is a more reliable confinement of fluid guided in the microchannel.
- the invention also relates to a method for producing a membrane for an in particular microfluidic cartridge.
- a first step an injection molding machine and an embossing stamp are provided, the embossing stamp having projections for forming recesses in the micrometer range in the membrane.
- the micrometer range can be understood as meaning a range between 1 and 5000 micrometers, preferably between 1 and 1000 micrometers, very preferably between 1 and 500 micrometers.
- a transport foil for the membrane is placed in a cavity of the injection molding machine and the embossing die is aligned in the cavity in relation to the transport foil.
- a plastic in particular a thermoplastic elastomer
- a plastic is injected to form the membrane and the recesses between the transport film and the embossing die, with the position of the embossing die being able to be adjusted in relation to the transport film during the injection.
- the membrane produced can be removed from the injection molding machine, preferably together with the transport film.
- the injection molding machine and the embossing die can be based on a known injection molding machine or on a known embossing die, as described for example in DE 10 2013 212 457 A1, with the embossing die having the projections according to the invention.
- the transport film can be, for example, a punched or injection-embossed film made from a polyolefin, such as polypropylene (PP), polymethylpentene (PMP) or polyethylene (PE), or from polyethylene terephthalate (PET).
- a polyolefin such as polypropylene (PP), polymethylpentene (PMP) or polyethylene (PE), or from polyethylene terephthalate (PET).
- a membrane according to the invention can advantageously be produced by this method, which is made possible in particular by the above-mentioned embossing stamp.
- the subject matter of the invention is therefore also an embossing die for producing a membrane for a particular microfluidic cartridge and an injection molding machine with such an embossing die.
- the embossing die has at least one projection for forming recesses in the micrometer range, in particular for microfluidic channels or electrical components in the membrane. According to a preferred development, at least one of the projections is designed to form undercuts in the membrane.
- one or more electrical components can be introduced into one or more of the recesses in the membrane in a fifth step
- the invention also relates to a method for producing a cartridge, in particular a microfluidic one, in which a membrane is produced according to the method described above and the membrane is then connected to at least one substrate to form the cartridge, in particular by welding the membrane to the substrate, for example via a laser welding process.
- FIG. 3 exemplary embodiments of the embossing die according to the invention and the injection molding machine according to the invention, as well as
- Figure 4 shows a flowchart for an associated exemplary embodiment of the method 600 according to the invention for producing the membrane 100 and the cartridge 200.
- Figure 1 shows a cross-sectional view of an embodiment of the membrane 100 according to the invention and the cartridge 200 according to the invention.
- the cartridge 200 comprises a first substrate 210 and a second substrate 220 as well as the membrane 100 arranged between them.
- the first and second substrate 210, 220 can consist of transparent plastic , for example on a polycarbonate basis.
- it can be a microfluidic cartridge 200 for detecting a pathogen in a body fluid contained in the cartridge 200, which is operated using a processing unit, such as in DE 10 2016 222 075 A1 or DE 10 2016 222 072 A1 described.
- the membrane 100 consists, for example, of a thermoplastic elastomer based on polyurethane and has a layer thickness of between 100 and 500 micrometers.
- the membrane 100 has several Recesses 110, 120, 130, which are preferably open to a surface 160 of the membrane 100.
- the walls 150 of the recesses 110, 120 are inclined with respect to the planar surface 160 of the membrane, so that the recesses 110, 120 taper towards the surface 160.
- the walls 150 are each designed as undercuts 150 in the membrane 100, as shown.
- a first recess 110 is designed as a microchannel, for example, while an electrical component 170 is accommodated in a second recess 120, for example a heating and/or cooling element such as a Peltier element or a sensor element such as a temperature sensor.
- a heating element it can be a printable heating element, as described for example in published application DE 10 2018 002 686 A1, or in particular a printable PTC heating element (for example from Quad Industries).
- the recesses 110, 120 and electrical components 170 accommodated therein are designed such that a flat surface 160 of the membrane 100 is ensured and a flat, flush connection of the membrane 100 to the two substrates 210, 220 is possible, as shown in FIG. In other words, the electrical component 170 is flush with the surface 160 . Due to the undercuts 150, the electrical component 170 is positively fixed in the recess 120 and cannot easily fall out.
- FIG. 2 shows a further exemplary embodiment of membrane 100 in plan view.
- This membrane 100 also includes a plurality of recesses 110 , 120 , 130 , the first recess 110 , for example, also being formed as a microchannel and a further recess 120 likewise having an electrical component 170 .
- the membrane 100 has, for example, an overall length of between 10 and 15 centimeters and an overall width of between 5 and 10 centimeters.
- the recesses 110 designed as microchannels 110 can, for example, have a length of several centimeters and a width and depth of between 1 and 5000 micrometers, preferably between 1 and 1000 micrometers, very preferably between 1 and 500 micrometers.
- FIG. 3 shows an exemplary embodiment of an embossing stamp 500 according to the invention, which can be used in an injection molding machine 1000 to produce the membrane 100 according to the invention.
- the embossing stamp 500 has a plurality of projections 510 for forming recesses 110, 120, 130 in the micrometer range in the membrane 100, in particular as described above for microfluidic channels 110 or electrical components 170 in the membrane.
- the projections 510 are designed to form undercuts 150 in the membrane.
- Figure 4 shows a flowchart 600 for an associated exemplary embodiment of the method 600 according to the invention for producing the membrane 100 and the cartridge 200, with which, for example, the examples of the membrane 100 according to the invention and the cartridge 200 shown in Figures 1 and 2 with the embossing stamp shown in Figure 3 500 can be made.
- the injection molding machine 1000 with the embossing die 500 is provided.
- the ejector side of an injection-compression molding tool of the injection molding machine is closed with the compression die 500 retracted, and the cavity 1010 is thus closed.
- thermoplastic elastomer which can be a thermoplastic elastomer based on polyurethane (TPU) or based on polystyrene (TPS), for example, is injected with a partial filling via the injection unit and, after a specific delay time, the embossing die 500 with its projections 510 is advanced ( Figure 2).
- the elastomer membrane 100 is molded with a layer thickness between 100 micrometers and 500 micrometers and integrated microchannels with a channel depth between 50 micrometers and 400 micrometers with undercuts.
- This status of the production method 600 is outlined in FIG.
- the undercuts 159 can be easily demoulded when the membrane is removed from the embossing die 500.
- the membrane 100 together with the transport foil 400 is removed from the opened cavity 1010 with the handling in a fifth step and fed to a printing system for the introduction of the electrical components 170 .
- the elastomeric membrane 100 can be fed to a production line for the cartridge 200 in a seventh step 607 and welded between the transparent substrates 210, 220 (also called carrier plates) without tension using a laser. This means that the electrical components are completely enclosed and sealed and stored in a mechanically stable manner, as in
- FIG. 1 shown for example.
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE112021006639.0T DE112021006639A5 (en) | 2020-12-23 | 2021-12-10 | Membrane for a microfluidic cartridge with recesses for a microchannel or an electrical component and method for producing a membrane and a cartridge with a membrane |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102020216542.4A DE102020216542A1 (en) | 2020-12-23 | 2020-12-23 | Membrane for a microfluidic cartridge with recesses for a microchannel or a sensor element and method for producing a membrane and a cartridge with a membrane |
DE102020216542.4 | 2020-12-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2022135965A1 true WO2022135965A1 (en) | 2022-06-30 |
Family
ID=79259245
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2021/085122 WO2022135965A1 (en) | 2020-12-23 | 2021-12-10 | Membrane for a microfluidic cartridge with recesses for a microchannel or an electric component, and method for producing a membrane and a cartridge with a membrane |
Country Status (2)
Country | Link |
---|---|
DE (2) | DE102020216542A1 (en) |
WO (1) | WO2022135965A1 (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1341655A2 (en) * | 2000-12-02 | 2003-09-10 | Aquamarijn Holding BV | Method of making a product with a micro or nano sized structure and product |
US9437893B2 (en) * | 2013-08-29 | 2016-09-06 | The Trustees Of The Stevens Institute Of Technology | In-membrane micro fuel cell |
EP3525279A1 (en) * | 2018-02-09 | 2019-08-14 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | Thermistors on flexible layers and its use for temperature measurements within a battery pack |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8753894B2 (en) | 2007-02-01 | 2014-06-17 | Diagnostic Biosensors, Llc | Integrated membrane sensor |
DE102013212457A1 (en) | 2013-06-27 | 2014-12-31 | Robert Bosch Gmbh | Method and device for producing a transparent molding |
WO2015155665A1 (en) | 2014-04-07 | 2015-10-15 | Tubitak | An electrochemical sensor array and apparatus |
US20160370210A1 (en) | 2015-06-18 | 2016-12-22 | Amphenol Thermometrics, Inc. | Modular flexible sensor array |
DE102016222075A1 (en) | 2016-11-10 | 2018-05-17 | Robert Bosch Gmbh | Processing system and method for processing a microfluidic cartridge with a processing unit |
DE102016222072A1 (en) | 2016-11-10 | 2018-05-17 | Robert Bosch Gmbh | Apparatus and method for tilted processing of microfluidic cartridges |
DE102017101262A1 (en) | 2017-01-24 | 2018-07-26 | Deutsches Zentrum für Luft- und Raumfahrt e.V. | Ultrathin foil thermistors |
-
2020
- 2020-12-23 DE DE102020216542.4A patent/DE102020216542A1/en not_active Withdrawn
-
2021
- 2021-12-10 WO PCT/EP2021/085122 patent/WO2022135965A1/en active Application Filing
- 2021-12-10 DE DE112021006639.0T patent/DE112021006639A5/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1341655A2 (en) * | 2000-12-02 | 2003-09-10 | Aquamarijn Holding BV | Method of making a product with a micro or nano sized structure and product |
US9437893B2 (en) * | 2013-08-29 | 2016-09-06 | The Trustees Of The Stevens Institute Of Technology | In-membrane micro fuel cell |
EP3525279A1 (en) * | 2018-02-09 | 2019-08-14 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | Thermistors on flexible layers and its use for temperature measurements within a battery pack |
Also Published As
Publication number | Publication date |
---|---|
DE102020216542A1 (en) | 2022-06-23 |
DE112021006639A5 (en) | 2023-11-16 |
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