WO2022109908A1 - Procédé et système d'ajustement de zone de sténose vasculaire et support de stockage - Google Patents

Procédé et système d'ajustement de zone de sténose vasculaire et support de stockage Download PDF

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Publication number
WO2022109908A1
WO2022109908A1 PCT/CN2020/131704 CN2020131704W WO2022109908A1 WO 2022109908 A1 WO2022109908 A1 WO 2022109908A1 CN 2020131704 W CN2020131704 W CN 2020131704W WO 2022109908 A1 WO2022109908 A1 WO 2022109908A1
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WIPO (PCT)
Prior art keywords
stenosis
interval
point
curve
diameter
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PCT/CN2020/131704
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English (en)
Chinese (zh)
Inventor
王之元
刘广志
王鹏
徐磊
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苏州润迈德医疗科技有限公司
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Publication of WO2022109908A1 publication Critical patent/WO2022109908A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/504—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of blood vessels, e.g. by angiography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computed tomography [CT]
    • A61B6/032—Transmission computed tomography [CT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
    • A61B6/5205—Devices using data or image processing specially adapted for radiation diagnosis involving processing of raw data to produce diagnostic data
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10—Complex mathematical operations
    • G06F17/15—Correlation function computation including computation of convolution operations

Definitions

  • the present invention relates to the technical field of coronary medicine, in particular to a method, a system and a storage medium for adjusting a vascular stenosis interval.
  • FFR is one of the coronary vascular evaluation parameters, and the microcirculation resistance index IMR belongs to the coronary vascular evaluation parameters.
  • the existing technology always tries to automatically determine the stenosis interval of blood vessels through algorithms.
  • due to the errors brought by the imaging equipment and the diversity of the patient's blood vessel conditions it is impossible to obtain the correct stenosis every time only through pixel information.
  • the user In the process of automatically judging the stenosis interval of the blood vessel through the algorithm, the user must reconfirm the result based on his own experience.
  • the invention provides a method, a system and a storage medium for adjusting the stenosis interval of blood vessels, so as to solve the problem that the stenosis interval of blood vessels cannot be automatically and accurately judged by algorithm alone, and provide a suitable manual interaction tool for users to adjust and confirm the results. .
  • the present application provides a method for adjusting a vascular stenosis interval, including:
  • a sliding rod is arranged on the corrected pipe diameter curve, one end of the sliding rod corresponds to the starting point, and one end of the sliding rod corresponds to the ending point;
  • the marks corresponding to the start point and the end point respectively slide corresponding distances on the corrected diameter curve, that is, the vascular stenosis interval is adjusted.
  • the method for obtaining a corrected diameter curve of a blood vessel includes:
  • the diameter curve obtained from the stenotic lesion vessel segment is a corrected diameter curve.
  • the method for obtaining a stenotic lesion vessel segment according to the fitted caliber curve and the true caliber curve includes:
  • the third stenosis lesion interval according to the stenosis point, that is, the precise stenosis lesion interval, the stenosis start point and the end point;
  • the diameter curve obtained in the third stenosis lesion interval is a corrected diameter curve.
  • the method for fitting a normal vascular diameter and obtaining a fitting diameter curve includes:
  • i represents the curve sampling point of the ith pipe diameter
  • n represents the sum of the number of pipe diameter curve sampling
  • xi represents the length of the curve sampling point of the ith pipe diameter
  • y i represents the pipe diameter at xi ;
  • the method for obtaining the first stenosis interval according to the fitted caliber curve and the true caliber curve includes:
  • the intersection is the first entry point of the narrow area, otherwise, the intersection is the first exit of the narrow area point;
  • the curve between the first entry point and the first exit point is the preliminarily determined stenosis position, that is, the first stenotic lesion interval.
  • the method for removing a misjudged stenosis area from the first stenotic lesion interval to obtain a second stenotic lesion interval includes;
  • a second stenotic lesion interval is obtained by removing a misjudged stenotic region from the first stenotic lesion interval according to the stenosis degree and/or the blood vessel centerline length.
  • the method for calculating a stenosis degree includes:
  • A represents the stenosis degree of the blood vessel
  • D min represents the minimum diameter of the blood vessel between the first entry point and the first exit point
  • D in and D out represent the vessel diameter of the first entry point and the first exit point, respectively vascular diameter.
  • the method for obtaining a second stenotic lesion interval by removing a misjudged stenotic area from the first stenotic lesion interval according to the stenosis degree and/or the length of the blood vessel centerline include:
  • the stenotic area obtained after removing the misjudged area is the second stenotic lesion interval.
  • the method for refitting a vessel diameter interval curve according to the second stenotic lesion interval, and the method for obtaining a stenosis point includes:
  • the point with the smallest pipe diameter in the refitted pipe diameter interval curve is obtained as the stenosis point.
  • the method for obtaining a third stenosis lesion interval according to the stenosis point includes:
  • the two points where the fitted pipe diameter interval curve and the real pipe diameter curve intersect are a second entry point and a second exit point, and the second entry point and the second The interval between the exit points is the third stenotic lesion interval, the second entry point is the stenosis start point, and the second exit point is the stenosis exit point.
  • the present application provides a system for adjusting a vascular stenosis interval, including: a device for obtaining a vessel diameter curve, a device for obtaining a vascular stenosis interval, a marking device and a sliding device;
  • the device for obtaining the diameter curve is used to obtain the corrected diameter curve of the obtained blood vessel
  • the vascular stenosis interval acquisition device is connected to the vessel diameter curve acquisition device, and is used for acquiring the vascular stenosis starting point, the ending point and the vascular stenosis interval;
  • the marking device which is connected to the vascular stenosis interval acquiring device, is used for setting markers on the starting point and the ending point respectively;
  • the sliding device is connected with the tube diameter curve acquisition device, the blood vessel stenosis interval acquisition device, and the marking device, and is used to set a sliding rod on the corrected tube diameter curve, and one end of the sliding rod corresponds to the The starting point, one end of the sliding rod corresponds to the ending point; if the sliding rod is slid, the marks corresponding to the starting point and the ending point respectively slide corresponding distances on the corrected pipe diameter curve, that is, The vascular stenosis interval is adjusted.
  • the device for obtaining a vascular stenosis interval includes a first stenosis lesion unit, a second stenosis lesion unit, a stenosis point unit and a third stenosis lesion unit;
  • the first stenosis lesion unit is connected to the vessel diameter curve obtaining device, and is configured to obtain the first stenosis lesion interval according to the fitted vessel diameter curve and the real vessel diameter curve;
  • the second stenotic lesion unit connected to the first stenotic lesion unit, and configured to remove a misjudged stenotic region from the first stenotic lesion interval to obtain a second stenotic lesion interval;
  • the stenosis point unit is connected to the pipe diameter curve obtaining device, and is used for obtaining the stenosis point according to the fitted pipe diameter interval curve;
  • the third stenosis lesion unit is connected to the stenosis point unit and the vessel diameter curve acquisition device, and is used for acquiring a third stenosis lesion interval according to the stenosis point, that is, a precise stenosis lesion interval.
  • the present application provides a computer storage medium, and when the computer program is executed by a processor, the above-mentioned method for adjusting a blood vessel stenosis interval is implemented.
  • the present application provides a method for adjusting the vascular stenosis interval, a method for realizing manual interaction and automatic algorithm coordination through a sliding rod, integrating the concept of human factors engineering into the operation and design of adjusting the vascular stenosis interval, allowing users to quickly confirm the blood vessel Narrow range, reduce the difficulty of operation and improve work efficiency.
  • FIG. 1 is a flowchart of a method for adjusting a vascular stenosis interval according to the present application
  • Fig. 2 is the flow chart of S100 of this application.
  • FIG. 4 is a flowchart of S140 of the application.
  • FIG. 8 is a structural block diagram of a system for adjusting a vascular stenosis interval according to the present application.
  • FIG. 9 is a structural block diagram of the apparatus 200 for obtaining a vascular stenosis interval according to the present application.
  • the present application provides a method for adjusting a vascular stenosis interval, including:
  • i represents the curve sampling point of the ith pipe diameter
  • n represents the sum of the number of pipe diameter curve sampling
  • xi represents the length of the curve sampling point of the ith pipe diameter
  • y i represents the pipe diameter at xi ;
  • the diameter curve obtained from the stenotic lesion vessel segment is a corrected diameter curve, including:
  • a first stenosis lesion interval including:
  • the curve between the first entry point and the first exit point is the initially determined stenosis position, that is, the first stenotic lesion interval.
  • S1421 calculate the stenosis, the specific formula: Among them, A represents the stenosis degree of the blood vessel, D min represents the minimum diameter of the blood vessel between the first entry point and the first exit point, D in and D out represent the vessel diameter of the first entry point and the first exit point, respectively vascular diameter.
  • S1423 remove the misjudged stenosis region from the first stenosis lesion interval according to the stenosis degree and/or the length of the blood vessel centerline to obtain a second stenosis lesion interval, including:
  • the stenotic region obtained after removing the misjudged region is the second stenotic lesion interval.
  • a third stenosis lesion interval according to the stenosis point that is, an accurate stenosis lesion interval, a stenosis start point and an end point, including: on both sides of the stenosis point, the fitted diameter interval curve and the real tube diameter interval
  • the two points where the diameter curve intersects are the second entry point and the second exit point, the interval between the second entry point and the second exit point is the third stenotic lesion interval, and the second entry point is the stenosis
  • the starting point, the second exit point is the narrow exit point.
  • the diameter curve obtained in the third stenosis lesion interval is a corrected diameter curve.
  • the present application provides a system for adjusting a vascular stenosis interval, including: a vessel diameter curve obtaining device 100 , a vessel stenosis interval obtaining device 200 , a marking device 300 and a sliding device 400 ; the vessel diameter curve obtaining device 100, used to obtain the modified diameter curve of the obtained blood vessel; the vessel stenosis interval obtaining device 200, connected to the vessel diameter curve obtaining device 100, is used to obtain the starting point, the ending point and the vessel stenosis interval of the vessel stenosis; the The marking device 300 is connected to the vascular stenosis interval obtaining device 200, and is used to set markers on the starting point and the ending point respectively; the sliding device 400 is connected to the vessel diameter curve obtaining device 100, the The vascular stenosis interval acquisition device 200 is connected to the marking device 300, and is used to set a sliding rod on the corrected diameter curve, one end of the sliding rod corresponds to the starting point, and one end of the sliding rod
  • the device 200 for obtaining a vascular stenosis interval includes a first stenosis lesion unit 210 , a second stenosis lesion unit 220 , a stenosis point unit 230 and a third stenosis lesion unit 240 ;
  • a stenosis lesion unit 210 connected to the vessel diameter curve obtaining device 100, for obtaining a first stenosis lesion section according to the fitted vessel diameter curve and the real vessel diameter curve;
  • the second stenosis lesion unit 220 connected to The first stenotic lesion unit 210 is connected to remove the misjudged stenotic region from the first stenotic lesion interval to obtain a second stenotic lesion interval;
  • the stenosis point unit 230 is connected to the vessel diameter curve acquisition device
  • the third stenosis lesion unit 240 is connected to the stenosis point unit 230 and the vessel diameter curve obtaining device 100, and is
  • the present application provides a computer storage medium, and when the computer program is executed by a processor, the above-mentioned method for adjusting a vascular stenosis interval is implemented.
  • aspects of the present invention may be embodied as a system, method or computer program product. Accordingly, various aspects of the present invention may be embodied in the form of an entirely hardware implementation, an entirely software implementation (including firmware, resident software, microcode, etc.), or a combination of hardware and software aspects, It may be collectively referred to herein as a "circuit,” "module,” or “system.” Furthermore, in some embodiments, various aspects of the present invention may also be implemented in the form of a computer program product on one or more computer-readable media having computer-readable program code embodied thereon. Implementation of the method and/or system of embodiments of the present invention may involve performing or completing selected tasks manually, automatically, or a combination thereof.
  • hardware for performing selected tasks according to embodiments of the invention may be implemented as a chip or a circuit.
  • selected tasks according to embodiments of the invention may be implemented as a plurality of software instructions executed by a computer using any suitable operating system.
  • one or more tasks according to exemplary embodiments of the method and/or system as herein are performed by a data processor, such as a computing platform for executing a plurality of instructions.
  • the data processor includes volatile storage for storing instructions and/or data and/or non-volatile storage for storing instructions and/or data, such as a magnetic hard disk and/or a Move media.
  • a network connection is also provided.
  • a display and/or user input device, such as a keyboard or mouse, is optionally also provided.
  • the computer-readable medium may be a computer-readable signal medium or a computer-readable storage medium.
  • the computer-readable storage medium can be, for example, but not limited to, an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus or device, or a combination of any of the above. More specific examples (non-exhaustive list) of computer-readable storage media would include the following:
  • a computer-readable storage medium can be any tangible medium that contains or stores a program that can be used by or in conjunction with an instruction execution system, apparatus, or device.
  • a computer-readable signal medium may include a propagated data signal in baseband or as part of a carrier wave, with computer-readable program code embodied thereon. Such propagated data signals may take a variety of forms, including but not limited to electromagnetic signals, optical signals, or any suitable combination of the foregoing.
  • a computer-readable signal medium can also be any computer-readable medium other than a computer-readable storage medium that can transmit, propagate, or transport the program for use by or in connection with the instruction execution system, apparatus, or device .
  • Program code embodied on a computer-readable medium may be transmitted using any suitable medium, including but not limited to wireless, wireline, optical fiber cable, RF, etc., or any suitable combination of the foregoing.
  • computer program code for performing operations for various aspects of the invention may be written in any combination of one or more programming languages, including object-oriented programming languages such as Java, Smalltalk, C++, and conventional procedural programming languages, such as The "C" programming language or similar programming language.
  • the program code may execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer, or entirely on the remote computer or server.
  • the remote computer may be connected to the user's computer through any kind of network - including a local area network (LAN) or a wide area network (WAN) - or may be connected to an external computer (eg using an Internet service provider via Internet connection).
  • LAN local area network
  • WAN wide area network
  • These computer program instructions can also be stored on a computer readable medium, the instructions cause a computer, other programmable data processing apparatus, or other device to operate in a particular manner, whereby the instructions stored on the computer readable medium produce the An article of manufacture of instructions implementing the functions/acts specified in one or more blocks of the flowcharts and/or block diagrams.
  • Computer program instructions can also be loaded on a computer (eg, a coronary artery analysis system) or other programmable data processing device to cause a series of operational steps to be performed on the computer, other programmable data processing device or other device to produce a computer-implemented process , such that instructions executing on a computer, other programmable apparatus, or other device provide a process for implementing the functions/acts specified in the flowchart and/or one or more block diagram blocks.
  • a computer eg, a coronary artery analysis system
  • other programmable data processing device to produce a computer-implemented process , such that instructions executing on a computer, other programmable apparatus, or other device provide a process for implementing the functions/acts specified in the flowchart and/or one or more block diagram blocks.

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Abstract

Procédé et système d'ajustement d'une zone de sténose vasculaire et support de stockage. Ledit procédé consiste : à acquérir une courbe de diamètre de tube corrigé d'un vaisseau sanguin (S100) ; à acquérir un point de début et un point de fin d'une sténose vasculaire et d'une zone de sténose vasculaire (S200) ; à fournir respectivement, des marques sur le point de début et le point de fin (S300) ; à fournir une tige coulissante sur la courbe de diamètre de tube corrigé, une extrémité de la tige coulissante correspondant au point de début, et l'autre extrémité de la tige coulissante correspondant au point de fin (S400) ; et si la tige coulissante est faite coulisser, lesdites marques correspondant respectivement au point de début et au point de fin coulissent de distances correspondantes sur la courbe de diamètre de tube corrigé, c'est-à-dire ajustent la zone de sténose vasculaire (S500). Dans ledit procédé, la distorsion de la définition directe d'une zone de sténose vasculaire est évitée, et le concept de facteurs humains est intégré, au moyen d'une tige coulissante, dans le fonctionnement et la conception pour ajuster la zone de sténose vasculaire. La combinaison d'une interaction manuelle et d'une détermination automatisée améliore efficacement la précision, réduit le risque d'utilisation de l'algorithme de détermination automatisée seul, et augmente la robustesse de l'ensemble du système.
PCT/CN2020/131704 2020-11-25 2020-11-26 Procédé et système d'ajustement de zone de sténose vasculaire et support de stockage WO2022109908A1 (fr)

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CN202011337599.XA CN112472112B (zh) 2020-11-25 2020-11-25 调节血管狭窄区间的方法、系统及存储介质
CN202011337599.X 2020-11-25

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CN114359128A (zh) * 2021-09-10 2022-04-15 数坤(北京)网络科技股份有限公司 一种血管狭窄的检测方法、装置及计算机可读介质
CN117179894B (zh) * 2023-11-07 2024-03-15 北京唯迈医疗设备有限公司 介入手术支架辅助选型和定位的装置、系统和存储介质

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CN101991420A (zh) * 2009-08-27 2011-03-30 上海西门子医疗器械有限公司 一种疑似血管狭窄区域的定位方法和系统
CN105380637A (zh) * 2014-09-02 2016-03-09 株式会社东芝 医用图像处理装置以及医用图像处理方法
CN106539622A (zh) * 2017-01-28 2017-03-29 北京欣方悦医疗科技有限公司 基于血流动力学分析的冠脉虚拟支架植入方法和系统
CN108932714A (zh) * 2018-07-23 2018-12-04 苏州润心医疗器械有限公司 冠脉ct图像的斑块分类方法
CN109843161A (zh) * 2016-09-30 2019-06-04 皇家飞利浦有限公司 用于确定针对狭窄评估的功能指数的装置
WO2020190976A2 (fr) * 2019-03-17 2020-09-24 Lightlab Imaging, Inc. Systèmes et procédés d'imagerie et d'évaluation artérielle et flux de travaux basés sur une interface utilisateur associés

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101991420A (zh) * 2009-08-27 2011-03-30 上海西门子医疗器械有限公司 一种疑似血管狭窄区域的定位方法和系统
CN105380637A (zh) * 2014-09-02 2016-03-09 株式会社东芝 医用图像处理装置以及医用图像处理方法
CN109843161A (zh) * 2016-09-30 2019-06-04 皇家飞利浦有限公司 用于确定针对狭窄评估的功能指数的装置
CN106539622A (zh) * 2017-01-28 2017-03-29 北京欣方悦医疗科技有限公司 基于血流动力学分析的冠脉虚拟支架植入方法和系统
CN108932714A (zh) * 2018-07-23 2018-12-04 苏州润心医疗器械有限公司 冠脉ct图像的斑块分类方法
WO2020190976A2 (fr) * 2019-03-17 2020-09-24 Lightlab Imaging, Inc. Systèmes et procédés d'imagerie et d'évaluation artérielle et flux de travaux basés sur une interface utilisateur associés

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