WO2022108540A1 - An herbal oral composition comprising natural ingredients - Google Patents
An herbal oral composition comprising natural ingredients Download PDFInfo
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- WO2022108540A1 WO2022108540A1 PCT/TR2020/051136 TR2020051136W WO2022108540A1 WO 2022108540 A1 WO2022108540 A1 WO 2022108540A1 TR 2020051136 W TR2020051136 W TR 2020051136W WO 2022108540 A1 WO2022108540 A1 WO 2022108540A1
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- oral composition
- composition according
- herbal
- herbal oral
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
Definitions
- the present invention relates to an herbal oral composition
- an herbal oral composition comprising pelargonium sidoides and at least one binding agent for the treatment of various respiratory diseases such as cold, cough, allergic asthma, seasonal allergic rhinitis, bronchitis, pharyngitis, laryngitis and pneumonitis.
- the invention further relates to a process of the composition for effective and safe use.
- Pelargonium sidoides African Geranium, Umckaloabo
- Pelargonium sidoides African Geranium, Umckaloabo
- Pelargonium sidoides has antiviral properties strengthening the immune system. It further has both antibacterial effects and antioxidative properties against some bacteria. Apart from that, it was also reported to boost the immune system of the respective organism and to have expectorant action by increasing the ciliary beat frequency of respiratory epithelial cells.
- W02006067600 discloses an herbal formulation comprising extracts from Adhatoda, Syzygium and Eucalyptus plants.
- the formulation further comprises unnatural ingredients.
- the application does not disclose a solution for the stability problem encountered in herbal formulations.
- US8053002 (B2) discloses herbal compositions derived from kenyan plants for the treatment of HIV and other infectious diseases.
- the composition further comprises extra and unnatural ingredients. In this application, a simple and effective process is not disclosed.
- an herbal oral composition comprises pelargonium sidoides extract with at least one binding agent which is natural.
- herbal oral composition having a high stability is formed by natural products without harmful effects.
- the main object of the present invention is to obtain an herbal oral composition comprising natural ingredients which overcome the above described problems in the prior art and has additive advantages over them.
- Another object of the present invention is to provide an herbal oral composition comprising pelargonium sidoides and at least one binding agent to protect the composition against the moisture and temperature to maintain the stability.
- Another object of the present invention is to eliminate the undesired side effects encountered while creating an herbal composition.
- an herbal oral composition comprises pelargonium sidoides extract and at least one binding agent which is natural.
- the amount of pelargonium sidoides is between 0.10% and 20.0% or 0.10% and 10.0% by weight in the composition.
- Suitable binding agent is selected from the group comprising isomalt, pectin, carrageenan, locust bean gum, alginate, gelatin, guar gum, xanthan gum, gum arabic, starch or mixture thereof. So, an herbal oral composition having both natural ingredients and high stability is obtained using plant-based binding agents.
- a binding agent is selected from the group comprising isomalt, pectin, carrageenan, locust bean gum or mixtures thereof.
- Isomalt is a sugar substitute, a type of sugar alcohol used primarily for its sugar-like physical properties. It has little to no impact on blood sugar levels and does not stimulate the release of insulin.
- a binding agent is isomalt and the amount of isomalt is between 0.10% and 90.0% by weight in the composition.
- Pectin is a heterogenous grouping of acidic structural polysaccharides found in fruit and vegetables and mainly prepared from waste citrus peel and apple pomace.
- a binding agent is pectin and the amount of pectin is between 0.10% and 50.0% by weight in the composition.
- Carrageenan is a collective term for polysaccharides prepared by alkaline extraction from red seaweed.
- the basic structure of carrageenan consists of alternating 3-linked - -D- galactopyranose and 4-linked-a-D-galactopyranose units.
- Locust bean gum is a galactomannan vegetable gum extracted from the seeds of the carob tree. It is polydisperse and consists of non-ionic molecules made up of about 2000 residues.
- a binding agent is carrageenan- locust bean gum mixtures and the amount of carrageenan- locust bean gum mixtures is between 0.10% and 90.0% by weight in the composition.
- the weight ratio of pelargonium sidoides to binding agents is in the range of 0.001-100.0.
- the herbal oral composition further comprises at least one extract which is selected from the group comprising zingiber officinale, propolis extract, echinacea purpurea, berberis vulgaris, panax ginseng, glycyrrhiza glabra, tilia or mixtures thereof.
- Ginger Zingiber officinale
- propolis extract echinacea purpurea
- berberis vulgaris berberis vulgaris
- panax ginseng glycyrrhiza glabra
- tilia glycyrrhiza glabra
- Ginger Zaingiber officinale
- Ginger is also called "warming herb” and used for a long time as an important medical herb. It comprises essential oils with ether comprising Zingiberene, Zingiberol, Gingerol and Shogol.
- the essential oils contained which are mixed with terpenoids give the special taste and scent of ginger.
- the bitter substances without essential oils which make the mouth feel warm are gingero
- Ginger has a wide area of usage. Ginger is preventive against cancer based on stopping the Epstein-barr virus activity. 6-gingerol and 6-paradol, among the active substances of ginger, are effective in stopping promyelocytic leucaemia by disturbing the DNA synthesis. It also has anti-inflammatory effect, is effective against arthritis and headache, and is bacteriostatic. It is used against nausea, spasm and fever in kids. Based on its antiseptic effect, it is used against stomach and intestine infections and even against food poisoning. It also prevents the coagulation of the blood and has blood thinning effect. It supports the cardiovascular system by making the platelets less adherent, this, in turn, causes a decrease in the problems of the circulation system. It is appetizing and can also be used against constipation. In addition to these, it has a warming and sedative effect in cough, flu, cold and other respiratory system diseases.
- Propolis is one of the most important bee products. Besides its antibacterial, antifungal, antiviral features, a great number of beneficial biological activities such as anti-inflammatory, anti-ulcer, local anesthetic, anti-tumor and immunity stimulant properties popularizes its usage in medicine, apitherapy, health nutrition and biocosmetic fields. It comprises 150 chemical compounds, more than 20 mineral substances, beeswax, resin and pollen. In chemical terms, propolis comprises a wide variety of extremely complex and potent terpenes, benzoic acids, caffeic acids, cinnamic acids, and phenolic acids. It has a high flavonoid content.
- Propolis is one of the most powerful antibiotics found in nature. It is rich in terms of amino acids and trace metals, has a very high vitamin content and contains at least 38 valuable bioflavonoids. It is an invaluable antioxidant based on its high bioflavonoid content. It was demonstrated to inactivate at least 21 bacteria species, 9 fungi species, 3 protozoa (including giardia), and a wide spectrum of viruses.
- Echinacea purpurea the purple coneflower, is a plant species widely used in the prophylaxis and/or treatment of infection, cold, cough, bronchitis, flu, in the treatment of infection of the urinary system, in the treatment of the sore throat and toothache, in boosting the immune system, and externally, in the treatment of snakebite, eczema, psoriasis, acne, wounds and burns.
- Echinacea purpurea is known to have immunostimulant, anti-inflammatory, antibacterial, antiviral, antifungal, anticancer, cicatrizant activities.
- Echinacea purpurea supports the production of interferon, thereby strengthening the defense system of the respective organism.
- Interferon activates the natural killer cells and induces these cells to bind to and destroy infected cells or tumor bearing cells.
- Interferon is effective in releasing the enzymes destroying the genetic structure of viruses and inhibiting their reproductive and spreading capabilities.
- Berberis vulgaris berries are edible and rich in vitamin C.
- Berberine is the main active alkaloid with a benzyl tetra hydroxy quinoline chemical structure which can be found in all parts of berberis vulgaris especially in its fruit (barberry). It is odorless but with a bitter taste powder which is sparingly soluble in methanol, slightly soluble in ethanol and very slightly soluble in water.
- Ginseng root is harvested after a cultivation period of 6 years and this part of the plant is used for therapeutic purposes. It comprises saponins (dammaran and oleanan derivatives; ginsenosites), polyacetylene derivatives and polysaccarides.
- saponins dammaran and oleanan derivatives; ginsenosites
- polyacetylene derivatives polysaccarides.
- the effects of Ginseng on the body are not local, and thus, one of the benefits of Ginseng is that it strengthens the entire body and helps in balancing entire body systems.
- Ginseng Panax ginseng
- Glycyrrhiza glabra a native of Southeastern Europe and Middle East, besides being used extensively in confectionary is also particularly well known for its medicinal properties.
- the dried licorice roots find extensive use in treating coughs, consumption and chest complaints and bronchitis.
- the roots and rhizomes of Glycyrrhiza glabra have been employed clinically for centuries for their anti-inflammatory, antiulcer, expectorant, antimicrobial and anxiolytic activities.
- Tilia Linden or limeflowers
- the herbal oral composition further comprises pharmaceutically acceptable excipients which are selected from the group comprising flavors, natural sweeteners or mixtures thereof.
- Suitable flavors are selected from the group comprising eucalyptus, ammonium glycyrrhizinate, menthol, peppermint, cinnamon, chocolate, vanillin, cherry, orange, strawberry, grape, black currant, raspberry, banana, red fruits, wild berries or mixtures thereof.
- the flavor is eucalyptus.
- Eucalyptus species which have analgesic and anti-inflammatory activities are also widely used in modern cosmetics, food, and pharmaceutical industries. Since eucalyptus has antibacterial and antiseptic qualities, it has been shown to protect against microbial growth that can promote a host of different symptoms and diseases in the body. In this invention, one important reason that the inventors preferably use eucalyptus is that it creates a cooling and refreshing effect.
- zinc sulfate monohydrate is used as a preservative.
- a natural sweetener is honey.
- Honey is the natural product processed by honeybees from flower nectars or plant secretions, by the aid of their own secretions. Honey is a nutritious, sweet and healthy food, and minor components of honey include proteins (0.25-0.5%), organic acids, aminoacids, vitamins, flavonoids and water.
- the honey was dried to a certain ratio using a microwave oven.
- the amount of water in honey is between 15.00% and 25.00% by weight.
- Honey has been used for the treatment of microbial infections since ancient times. In recent years there has been a resurgence of interest in the therapeutic efficacy of honey. While it may naturally have a long shelf life, heating and cooling the spread too many times can cause it to lose its color and aroma. Shelf-life of honey depends on botanical origin as well as processing.
- the herbal oral composition is in the form of a solid oral composition.
- the herbal oral composition is in the dosage form of lozenge, tablet, capsule, oral strip. According to one embodiment of the present invention, the dosage form of the herbal oral composition is lozenge.
- Example 1 Lozenge comprising pelargonium sidoides extract and isomalt
- Example 2 Lozenge comprising pelargonium sidoides extract and pectin
- Example 3 Lozenge comprising pelargonium sidoides extract and carrageenan-locust bean gum mixture
- Example 4 Lozenge comprising pelargonium sidoides extract and carrageenan-locust bean gum mixture and pectin
- Example 5 Lozenge comprising pelargonium sidoides extract and carrageenan-locust bean gum mixture and isomalt
- Example 6 Lozenge comprising pelargonium sidoides extract and pectin and isomalt
- Example 7 Lozenge comprising pelargonium sidoides extract and pectin and isomalt and carrageenan-locust bean gum mixture Process for the described above examples;
- the process for the preparation of the lozenge comprises the following steps: a) Adding dehumidified honey into a steel container, b) Adding herbal extracts, binding agents and other excipients and then, mixing with a homogenizer, c) Filling the mixture in lozenge molds d) Then, taking the mixture from the molds by cooling from the horizontal conveyor.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Nutrition Science (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Zoology (AREA)
- Mycology (AREA)
- Physiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to an herbal oral composition comprising pelargonium sidoides and at least one binding agent for the treatment of various respiratory diseases such as cold, cough, allergic asthma, seasonal allergic rhinitis, bronchitis, pharyngitis, laryngitis and pneumonitis. The invention further relates to a process of the composition for effective and safe use.
Description
AN HERBAL ORAL COMPOSITION COMPRISING NATURAL INGREDIENTS
FIELD OF THE INVENTION
The present invention relates to an herbal oral composition comprising pelargonium sidoides and at least one binding agent for the treatment of various respiratory diseases such as cold, cough, allergic asthma, seasonal allergic rhinitis, bronchitis, pharyngitis, laryngitis and pneumonitis. The invention further relates to a process of the composition for effective and safe use.
BACKGROUND OF THE INVENTION
In recent years, the use of various herbs and/or herbal medical products for the prevention and treatment of diseases and alleviating the effects thereof have been gradually increasing in all societies. Throughout human history, there have been and still are attempt for treating many diseases (diabetes, jaundice, dyspnea, etc.) by using some herbs. According to the records of the World Health Organization (WHO), a large proportion of the world's population (70-80%) make use of herbs for therapeutic or prophylactic purposes. Additionally, around 25% of prescription drugs in developed countries are composed of plant-based active agents (vinblastine, reserpine, quinine, aspirin, etc.).
Pelargonium sidoides (African Geranium, Umckaloabo) is a plant species widely used in the treatment and prevention of, or in the alleviation and/or elimination of the symptoms of cold and respiratory tract disease (pharyngitis, sinusitis, acute bronchitis, tonsillitis). It was determined to be effective in increasing the generation of natural killer cells and tumor necrosis factor alpha, and to enhance the release of interferon beta. Pelargonium sidoides has antiviral properties strengthening the immune system. It further has both antibacterial effects and antioxidative properties against some bacteria. Apart from that, it was also reported to boost the immune system of the respective organism and to have expectorant action by increasing the ciliary beat frequency of respiratory epithelial cells. In a multicenter study conducted by the Pneumology Department of a German University Hospital (2000) on acute bronchitis patients, including adults, children, and infants, it was determined that an extract of the roots of Pelargonium sidoides reduced the severity of the symptoms after 7 days treatment from 6.3 to 0.9 according to the average bronchitis severity score. A study published in "Acta Paediatrica" in April 2010, showed that preparations extracted from herbal roots were much more effective in the treatment of acute bronchitis as compared to placebo. A study group of children aged 6 to 18 years, taking the herbal extracts experienced less coughing, sputum, and bed rest times versus placebo. By assessing the results of four placebo-controlled clinic trials, the researchers at the Medical Center, the University of
Pittsburgh, concluded that a standardized extract of Pelargonium sidoides showed a much better performance in alleviating the bronchitis symptoms versus placebo in a 7-day treatment period.
W02006067600 (A2) discloses an herbal formulation comprising extracts from Adhatoda, Syzygium and Eucalyptus plants. The formulation further comprises unnatural ingredients. Also, the application does not disclose a solution for the stability problem encountered in herbal formulations.
US8053002 (B2) discloses herbal compositions derived from kenyan plants for the treatment of HIV and other infectious diseases. The composition further comprises extra and unnatural ingredients. In this application, a simple and effective process is not disclosed.
In the prior art, there are herbal formulations for various treatments, but chemicals are used to improve stability or protect the product for a long time. It is still needed to provide a composition which is natural with effective and herbal ingredients.
In the present invention, an herbal oral composition comprises pelargonium sidoides extract with at least one binding agent which is natural. Thus, herbal oral composition having a high stability is formed by natural products without harmful effects.
DETAILED DESCRIPTION OF THE INVENTION
The main object of the present invention is to obtain an herbal oral composition comprising natural ingredients which overcome the above described problems in the prior art and has additive advantages over them.
Another object of the present invention is to provide an herbal oral composition comprising pelargonium sidoides and at least one binding agent to protect the composition against the moisture and temperature to maintain the stability.
Another object of the present invention is to eliminate the undesired side effects encountered while creating an herbal composition.
According to one embodiment of the present invention, an herbal oral composition comprises pelargonium sidoides extract and at least one binding agent which is natural.
According to one embodiment of the present invention, the amount of pelargonium sidoides is between 0.10% and 20.0% or 0.10% and 10.0% by weight in the composition.
Suitable binding agent is selected from the group comprising isomalt, pectin, carrageenan, locust bean gum, alginate, gelatin, guar gum, xanthan gum, gum arabic, starch or mixture thereof. So, an herbal oral composition having both natural ingredients and high stability is obtained using plant-based binding agents.
According to one embodiment of the present invention, a binding agent is selected from the group comprising isomalt, pectin, carrageenan, locust bean gum or mixtures thereof.
Isomalt is a sugar substitute, a type of sugar alcohol used primarily for its sugar-like physical properties. It has little to no impact on blood sugar levels and does not stimulate the release of insulin.
According to one embodiment of the present invention, a binding agent is isomalt and the amount of isomalt is between 0.10% and 90.0% by weight in the composition.
Pectin is a heterogenous grouping of acidic structural polysaccharides found in fruit and vegetables and mainly prepared from waste citrus peel and apple pomace.
According to one embodiment of the present invention, a binding agent is pectin and the amount of pectin is between 0.10% and 50.0% by weight in the composition.
Carrageenan is a collective term for polysaccharides prepared by alkaline extraction from red seaweed. The basic structure of carrageenan consists of alternating 3-linked - -D- galactopyranose and 4-linked-a-D-galactopyranose units.
Locust bean gum is a galactomannan vegetable gum extracted from the seeds of the carob tree. It is polydisperse and consists of non-ionic molecules made up of about 2000 residues.
According to one embodiment of the present invention, a binding agent is carrageenan- locust bean gum mixtures and the amount of carrageenan- locust bean gum mixtures is between 0.10% and 90.0% by weight in the composition.
According to one embodiment of the present invention, the weight ratio of pelargonium sidoides to binding agents is in the range of 0.001-100.0.
According to one embodiment of the present invention, the herbal oral composition further comprises at least one extract which is selected from the group comprising zingiber officinale, propolis extract, echinacea purpurea, berberis vulgaris, panax ginseng, glycyrrhiza glabra, tilia or mixtures thereof.
Ginger (Zingiber officinale) is also called "warming herb" and used for a long time as an important medical herb. It comprises essential oils with ether comprising Zingiberene, Zingiberol, Gingerol and Shogol. The essential oils contained which are mixed with terpenoids give the special taste and scent of ginger. The bitter substances without essential oils which make the mouth feel warm are gingerol and zingeron.
Ginger has a wide area of usage. Ginger is preventive against cancer based on stopping the Epstein-barr virus activity. 6-gingerol and 6-paradol, among the active substances of ginger, are effective in stopping promyelocytic leucaemia by disturbing the DNA synthesis. It also has anti-inflammatory effect, is effective against arthritis and headache, and is bacteriostatic. It is used against nausea, spasm and fever in kids. Based on its antiseptic effect, it is used against stomach and intestine infections and even against food poisoning. It also prevents the coagulation of the blood and has blood thinning effect. It supports the cardiovascular system by making the platelets less adherent, this, in turn, causes a decrease in the problems of the circulation system. It is appetizing and can also be used against constipation. In addition to these, it has a warming and sedative effect in cough, flu, cold and other respiratory system diseases.
Propolis is one of the most important bee products. Besides its antibacterial, antifungal, antiviral features, a great number of beneficial biological activities such as anti-inflammatory, anti-ulcer, local anesthetic, anti-tumor and immunity stimulant properties popularizes its usage in medicine, apitherapy, health nutrition and biocosmetic fields. It comprises 150 chemical compounds, more than 20 mineral substances, beeswax, resin and pollen. In chemical terms, propolis comprises a wide variety of extremely complex and potent terpenes, benzoic acids, caffeic acids, cinnamic acids, and phenolic acids. It has a high flavonoid content.
Propolis is one of the most powerful antibiotics found in nature. It is rich in terms of amino acids and trace metals, has a very high vitamin content and contains at least 38 valuable bioflavonoids. It is an invaluable antioxidant based on its high bioflavonoid content. It was demonstrated to inactivate at least 21 bacteria species, 9 fungi species, 3 protozoa (including giardia), and a wide spectrum of viruses.
Echinacea purpurea, the purple coneflower, is a plant species widely used in the prophylaxis and/or treatment of infection, cold, cough, bronchitis, flu, in the treatment of infection of the urinary system, in the treatment of the sore throat and toothache, in boosting the immune system, and externally, in the treatment of snakebite, eczema, psoriasis, acne, wounds and burns. Echinacea purpurea is known to have immunostimulant, anti-inflammatory,
antibacterial, antiviral, antifungal, anticancer, cicatrizant activities. The compounds accounting for these activities are thought to be polysaccharides, glycoproteins, alkylamides, and caffeic acid derivatives (cichoric acid, echinacoside). Echinacea purpurea supports the production of interferon, thereby strengthening the defense system of the respective organism. Interferon activates the natural killer cells and induces these cells to bind to and destroy infected cells or tumor bearing cells. Interferon is effective in releasing the enzymes destroying the genetic structure of viruses and inhibiting their reproductive and spreading capabilities.
Berberis vulgaris berries are edible and rich in vitamin C. Berberine is the main active alkaloid with a benzyl tetra hydroxy quinoline chemical structure which can be found in all parts of berberis vulgaris especially in its fruit (barberry). It is odorless but with a bitter taste powder which is sparingly soluble in methanol, slightly soluble in ethanol and very slightly soluble in water.
Ginseng root is harvested after a cultivation period of 6 years and this part of the plant is used for therapeutic purposes. It comprises saponins (dammaran and oleanan derivatives; ginsenosites), polyacetylene derivatives and polysaccarides. The effects of Ginseng on the body are not local, and thus, one of the benefits of Ginseng is that it strengthens the entire body and helps in balancing entire body systems. Ginseng (Panax ginseng) is an antioxidant and an important immunity system improver which increases the number of immunity system cells in the body. It is useful in the treatment of bronchitis, asthma and circulation problems. According to a study conducted by American scientists, the flu risk of people who are administered 200mg ginseng root capsules twice a day reduced by 31%. In the laboratory and animal experiments, it is found that it is effective against prostate, stomach, kidney, liver, large intestine, brain and lung cancers. In animals with prostate cancer, it prevented the development of cancer.
Glycyrrhiza glabra a native of Southeastern Europe and Middle East, besides being used extensively in confectionary is also particularly well known for its medicinal properties. The dried licorice roots find extensive use in treating coughs, consumption and chest complaints and bronchitis. In the traditional system of medicine, the roots and rhizomes of Glycyrrhiza glabra have been employed clinically for centuries for their anti-inflammatory, antiulcer, expectorant, antimicrobial and anxiolytic activities.
Linden or limeflowers (Tilia) provides flower-derived preparations that are reported to provide a relaxant and healing effect on blood vessel walls. They have been suggested for persons with cardiovascular conditions who exhibit pronounced anxiety or tension factor. Dosages of
1-4 g. dried flowers equivalent, three or more times daily have been recommended. Teas prepared from Tilia are recognized as traditional domestic favorites.
According to one embodiment of the present invention, the herbal oral composition further comprises pharmaceutically acceptable excipients which are selected from the group comprising flavors, natural sweeteners or mixtures thereof.
Suitable flavors are selected from the group comprising eucalyptus, ammonium glycyrrhizinate, menthol, peppermint, cinnamon, chocolate, vanillin, cherry, orange, strawberry, grape, black currant, raspberry, banana, red fruits, wild berries or mixtures thereof.
According to one embodiment of the present invention, the flavor is eucalyptus.
Eucalyptus species which have analgesic and anti-inflammatory activities are also widely used in modern cosmetics, food, and pharmaceutical industries. Since eucalyptus has antibacterial and antiseptic qualities, it has been shown to protect against microbial growth that can promote a host of different symptoms and diseases in the body. In this invention, one important reason that the inventors preferably use eucalyptus is that it creates a cooling and refreshing effect.
When eucalyptus is used as the flavoring agent, it is observed that it shows a supporting effect for said formulation due to the refreshing, cooling and smoothening effect of scent and the patients administered with said formulation feels instant relief and alleviation of symptoms, thus, it helped them feel better within a shorter period of time.
According to one embodiment of the present invention, optionally, zinc sulfate monohydrate is used as a preservative.
According to one embodiment of the present invention, a natural sweetener is honey.
Honey is the natural product processed by honeybees from flower nectars or plant secretions, by the aid of their own secretions. Honey is a nutritious, sweet and healthy food, and minor components of honey include proteins (0.25-0.5%), organic acids, aminoacids, vitamins, flavonoids and water.
According to one embodiment of the present invention, the honey was dried to a certain ratio using a microwave oven. The amount of water in honey is between 15.00% and 25.00% by weight.
Honey has been used for the treatment of microbial infections since ancient times. In recent years there has been a resurgence of interest in the therapeutic efficacy of honey. While it may naturally have a long shelf life, heating and cooling the spread too many times can cause it to lose its color and aroma. Shelf-life of honey depends on botanical origin as well as processing.
According to one embodiment of the present invention, the herbal oral composition is in the form of a solid oral composition.
According to one embodiment of the present invention, the herbal oral composition is in the dosage form of lozenge, tablet, capsule, oral strip. According to one embodiment of the present invention, the dosage form of the herbal oral composition is lozenge.
Example 1 : Lozenge comprising pelargonium sidoides extract and isomalt
Example 2: Lozenge comprising pelargonium sidoides extract and pectin
Example 3: Lozenge comprising pelargonium sidoides extract and carrageenan-locust bean gum mixture
Example 4: Lozenge comprising pelargonium sidoides extract and carrageenan-locust bean gum mixture and pectin
Example 5: Lozenge comprising pelargonium sidoides extract and carrageenan-locust bean gum mixture and isomalt
Example 6: Lozenge comprising pelargonium sidoides extract and pectin and isomalt
Example 7: Lozenge comprising pelargonium sidoides extract and pectin and isomalt and carrageenan-locust bean gum mixture
Process for the described above examples;
The process for the preparation of the lozenge comprises the following steps: a) Adding dehumidified honey into a steel container, b) Adding herbal extracts, binding agents and other excipients and then, mixing with a homogenizer, c) Filling the mixture in lozenge molds d) Then, taking the mixture from the molds by cooling from the horizontal conveyor.
Claims
1. An herbal oral composition comprising pelargonium sidoides extract and at least one binding agent.
2. The herbal oral composition according to claim 1, wherein the amount of pelargonium sidoides is between 0.10% and 20.0% or 0.10% and 10.0% by weight in the composition.
3. The herbal oral composition according to claim 1, wherein at least one binding agent is selected from the group comprising isomalt, pectin, carrageenan, locust bean gum, alginate, gelatin, guar gum, xanthan gum, gum arabic, starch or mixture thereof.
4. The herbal oral composition according to claim 3, wherein at least one binding agent is selected from the group comprising isomalt, pectin, carrageenan, locust bean gum or mixture thereof.
5. The herbal oral composition according to claim 1, wherein the weight ratio of pelargonium sidoides to binding agents is in the range of 0.001-100.0.
6. The herbal oral composition according to claim 1, further comprising at least one extract which is selected from the group comprising zingiber officinale, propolis extract, echinacea purpurea, berberis vulgaris, panax ginseng, glycyrrhiza glabra, tilia or mixtures thereof.
7. The herbal oral composition according to claim 1, further comprising pharmaceutically acceptable excipients which are selected from the group comprising flavors, natural sweeteners or mixtures thereof.
8. The herbal oral composition according to claim 7, wherein flavors are selected from the group comprising eucalyptus, ammonium glycyrrhizinate, menthol, peppermint, cinnamon, chocolate, vanillin, cherry, orange, strawberry, grape, black currant, raspberry, banana, red fruits, wild berries or mixtures thereof.
9. The herbal oral composition according to claim 7, wherein the natural sweetener is honey.
10. The herbal oral composition according to claim 1, wherein the oral composition is in the form of a solid oral composition.
The herbal oral composition according to claim 10, wherein the composition is in the dosage form of lozenge, tablet, capsule or oral strip. The herbal oral composition according to claim 11, wherein the dosage form of the composition is lozenge.
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1829548A1 (en) * | 2006-03-01 | 2007-09-05 | Divapharma Chur AG | Use of Pelargonium sidoides extracts in combination with Plantago lanceolata extracts for the preparation of a medicament for the treatment of pharyngitis |
CN106727853A (en) * | 2017-01-11 | 2017-05-31 | 珠海聚焦先导生物研究院有限公司 | A kind of cough lozenge |
WO2019209228A2 (en) * | 2017-12-29 | 2019-10-31 | Montero Gida Sanayi Ve Ticaret Anonim Sirketi | Solid oral compositions comprising dried honey and herbal extracts |
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2020
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1829548A1 (en) * | 2006-03-01 | 2007-09-05 | Divapharma Chur AG | Use of Pelargonium sidoides extracts in combination with Plantago lanceolata extracts for the preparation of a medicament for the treatment of pharyngitis |
CN106727853A (en) * | 2017-01-11 | 2017-05-31 | 珠海聚焦先导生物研究院有限公司 | A kind of cough lozenge |
WO2019209228A2 (en) * | 2017-12-29 | 2019-10-31 | Montero Gida Sanayi Ve Ticaret Anonim Sirketi | Solid oral compositions comprising dried honey and herbal extracts |
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