WO2022088324A1

WO2022088324A1 - Massage cream for relieving muscle discomfort

Info

Publication number: WO2022088324A1
Application number: PCT/CN2020/130991
Authority: WO
Inventors: 李易春
Original assignee: 乐比(广州)健康产业有限公司
Priority date: 2020-10-27
Filing date: 2020-11-24
Publication date: 2022-05-05
Also published as: CN112089819A

Abstract

Disclosed is a massage cream for relieving muscle discomfort, comprising the following raw materials: water, a Houttuynia cordata fermentation liquid, glycerin, safflower extract, juniper fruit extract, ginger oil, holly oil, peppermint essential oil, rosemary essential oil, vanillyl butyl ether, allantoin, cannabidiol, and modified diatomite. By adding the Houttuynia cordata fermented liquid, the cream can clear heat and detoxify, reduce swelling and treat sores, and promote blood circulation; the holly oil can promote rapid blood circulation in painful areas, relax the meridians and activate the collaterals, and relieve pain; the rosemary essential oil can be used to treat muscle sprains and is very effective in treating various muscle problems; the cannabidiol can have an effect of soothing muscles and relieving discomfort; the Houttuynia cordata fermentation liquid and the cannabidiol can have synergistic effect; by adding modified diatomite, which is a porous structure having strong adsorption, the cream can adsorb many medicinal components, so that the medicinal effect can be fully exerted and the medicinal effect lasts longer.

Description

A massage cream to soothe muscle discomfort

technical field

The invention relates to a massage ointment, in particular to a massage ointment for relieving muscle discomfort.

Background technique

Modern people's life is not only fast-paced, often working overtime, eating irregularly, and mentally stressing, but also living in a dry environment in the office for a long time, sitting in front of the computer for a long time, and improper sitting posture. Joint and muscle discomfort.

The massage cream combines physical massage and cream to dredge the meridians and collaterals and dispel cold. Reconcile qi and blood, relieve muscle tension and fatigue, gradually reduce and eliminate pain and soreness, and restore muscle relaxation. Appropriate massage, suddenly feel relaxed and comfortable.

Now there are many kinds of massage creams on the market. Many massage creams contain a large amount of synthetic chemical components, which are not suitable for long-term use, and also have a certain degree of irritation to the skin, and the effect is relatively poor.

SUMMARY OF THE INVENTION

The purpose of the embodiments of the present invention is to provide a massage cream for relieving muscle discomfort, so as to solve the above problems.

To achieve the above object, the present invention provides the following technical solutions:

A massage cream for relieving muscle discomfort, comprising the following raw materials by weight: 40-50 parts of water, 20-30 parts of Houttuynia cordata fermented liquid, 10-20 parts of glycerin, 2-6 parts of safflower extract, juniper Fruit extract 1-5 parts, ginger oil 1-3 parts, wintergreen oil 2-4 parts, peppermint essential oil 3-5 parts, rosemary essential oil 2-4 parts, vanillyl butyl ether 0.5-1.5 parts, urine 0.4-1 part of cystin, 0.2-0.6 part of cannabidiol, and 10-20 parts of modified diatomaceous earth.

In an optional scheme: including the following raw materials by weight: 42-48 parts of water, 22-28 parts of Houttuynia cordata fermentation broth, 12-18 parts of glycerin, 3-5 parts of safflower extract, juniper fruit 2-4 parts of extract, 1.5-2.5 parts of ginger oil, 2.5-3.5 parts of wintergreen oil, 3.5-4.5 parts of peppermint essential oil, 2.5-3.5 parts of rosemary essential oil, 0.8-1.2 parts of vanillyl butyl ether, allantoic 0.6-0.8 parts of calcium, 0.3-0.5 parts of cannabidiol, and 13-17 parts of modified diatomaceous earth.

In an optional scheme: include the following raw materials by weight: 45 parts of water, 25 parts of Houttuynia cordata fermentation broth, 15 parts of glycerin, 4 parts of safflower extract, 3 parts of juniper fruit extract, 2 parts of ginger oil parts, 3 parts of wintergreen oil, 4 parts of peppermint essential oil, 3 parts of rosemary essential oil, 1 part of vanillyl butyl ether, 0.7 parts of allantoin, 0.4 parts of cannabidiol, and 15 parts of modified diatomaceous earth.

In an optional solution: the preparation method of the Houttuynia cordata fermentation broth is as follows: wash the Houttuynia cordata, drain, place in a -10°C freezer, seal and freeze for 2-3 hours, add buffer to homogenize Treatment to obtain Houttuynia cordata slurry, then adjust the pH to 8-9, then inoculate with Lactobacillus spp., sealed and fermented at a constant temperature for 150-180 minutes at 25-35° C. After high temperature sterilization, filter and remove impurities to obtain the fishy fishy fish. Grass fermentation broth.

In an optional solution: the buffer is any one of acetic acid-sodium acetate buffer, potassium phosphate buffer, and sodium citrate buffer.

In an optional scheme: the preparation method of the safflower extract is as follows: the preparation method of the safflower extract is as follows: take safflower, wash, dry, pulverize, put into a percolator, and use 6 - Perform percolation extraction with 8 times the weight of 10% ethanol aqueous solution to obtain percolation extract and percolation extraction residue, add the percolation extraction residue to 5-7 times the weight of 15% ethanol aqueous solution, soak for 2-3 hours, and ultrasonically extract for 20 -40min, filter to obtain ultrasonic extraction solution and ultrasonic extraction residue, add ultrasonic extraction residue to 4-6 times the weight of water, put it into an autoclave, decoct at high pressure for 20-30min, filter to obtain high-pressure extraction solution and high-pressure extraction residue , the percolation extraction solution, the ultrasonic extraction solution and the high-pressure extraction solution are combined, evaporated under reduced pressure and concentrated to 10% of the original volume to obtain the safflower extract.

In an optional scheme: the preparation method of the juniper fruit extract is as follows: take the juniper fruit, wash, dry, put it in a frying container, heat with a simmer, fry until it swells, pulverize and sieve, Then the powder is mixed in the oxidizing lye solution according to the weight ratio of 1:6-8 and left to stand for 1-3 hours to form a mixed solution, and then the mixed solution is put into a microwave reactor with a microwave power of 400-450w to react for 10 After -20min, take out and filter the filter residue to obtain a filtrate, and the obtained filtrate is concentrated under reduced pressure to obtain a juniper fruit extract.

In an optional solution, the oxidizing lye solution is prepared by mixing sodium hydroxide with a concentration of 10% and sodium hypochlorite with a concentration of 1% in a weight ratio of 1:4-5.

In an optional solution: the preparation method of the modified diatomite is as follows: take the diatomite and place it in a muffle furnace to program the temperature to 800-900°C, roast at a constant temperature for 2 hours, and grind to a particle size of 200 after cooling. -300 mesh; then add water with a mass of 10-12 times the mass of diatomite and sodium lignosulfonate with a mass of 0.2-0.4 times the mass of diatomite and stir to form a suspension slurry, add chitosan to the suspension slurry and stir well, cooperate with ultrasonic waves After hydrothermal treatment for 2 hours, it is finally centrifuged. After centrifugation, vacuum filtration is performed and spray-dried to obtain modified diatomaceous earth.

The preparation method of the above-mentioned massage cream for relieving muscle discomfort, the steps are as follows:

1) adding water, Houttuynia cordata fermented liquid and glycerin into the water-phase pot for homogeneous stirring, so that they are uniformly dispersed, and keep the temperature above 60°C;

2) Then add modified diatomaceous earth, safflower extract, juniper fruit extract, ginger oil, wintergreen oil, peppermint essential oil, rosemary essential oil, heat to 80°C, stir while heating, and keep stirring for 30 minutes. Cool down by 50℃;

3) Finally, add vanillyl butyl ether, allantoin, and cannabidiol, stir and mix evenly, cool down to 30° C., filter and discharge the material to obtain the desired massage cream for relieving muscle discomfort.

Compared with the prior art, the beneficial effects of the embodiments of the present invention are as follows:

By adding Houttuynia cordata fermented liquid, it can clear heat and detoxify, reduce swelling and treat sores, and promote blood circulation. By adding safflower extract, it has the functions of treating bruises, swelling and pain, promoting blood circulation, removing blood stasis and relieving pain, and also has the function of fever. , By adding juniper fruit extract, it has the functions of promoting qi, relieving pain, expelling wind and dehumidifying, and can relieve rheumatism and joint pain, dermatitis, muscle numbness and pain, and is effective against Staphylococcus, Streptococcus, Shigella, Pasteurella, Arc cholera. Bacteria have strong antibacterial effects. Ginger oil can activate the whole body's mental tissue, make the whole body fever, dispel wind, relieve muscle soreness, as well as sterilize and relieve itching. The main components of peppermint essential oil are antipruritic, analgesic, antiseptic, Stimulating, anesthetizing, cooling and anti-inflammatory effects, wintergreen oil can promote rapid blood circulation in painful areas, relax meridians, relieve pain, rosemary essential oil can be used to treat muscle sprains, very effective in dealing with various muscle problems, cannabidiol , can play a role in soothing muscles and relieving discomfort. Both Houttuynia cordata and cannabidiol synergistically synergize. By adding modified diatomaceous earth, the porous structure has strong adsorption and can absorb a lot of medicinal ingredients, making The effect of the drug is fully exerted, and the effect of the drug lasts longer.

Detailed ways

The following examples will describe the present invention in detail, and each embodiment exemplified in the present invention is only used to illustrate the present invention, and not to limit the scope of the present invention. Any obvious modifications or changes made to the present invention do not depart from the spirit and scope of the present invention.

In order to solve the problem that the existing soothing plaster is not obvious, by adding Houttuynia cordata fermented liquid, it can clear heat and detoxify, reduce swelling and treat sores, and promote blood circulation. It also has the functions of removing blood stasis and relieving pain, and also has the function of fever. By adding juniper fruit extract, it has the functions of promoting qi and relieving pain, dispelling wind and dehumidification, and can relieve rheumatism and joint pain, dermatitis, muscle numbness and pain, and has the effect of preventing staphylococcus. , Streptococcus, Shigella, Pasteurella, and Vibrio cholera have strong antibacterial effects. Ginger oil can activate the whole body's mental tissue, make the whole body fever, dispel wind, relieve muscle soreness, as well as sterilize and relieve itching. The main components of peppermint essential oil are antipruritic, analgesic, antiseptic, stimulating, anesthetic, cooling and anti-inflammatory. Wintergreen oil can promote rapid blood circulation in the painful area, soothe meridians and relieve pain. Rosemary essential oil can be used to treat muscle sprains. , It is very effective for dealing with various muscle problems. Cannabidiol can soothe muscles and relieve discomfort. Houttuynia cordata fermentation liquid and cannabidiol synergize. It has strong adsorption and can absorb a lot of medicinal components, so that the medicinal effect can be fully exerted and the medicinal effect lasts for a longer time.

Example 1

First weigh the following raw materials by weight: 40 parts of water, 20 parts of Houttuynia cordata fermentation broth, 10 parts of glycerin, 2 parts of safflower extract, 1 part of juniper fruit extract, 1 part of ginger oil, and wintergreen oil 2 parts, 3 parts of peppermint essential oil, 2 parts of rosemary essential oil, 0.5 part of vanillyl butyl ether, 0.4 part of allantoin, 0.2 part of cannabidiol, 10 parts of modified diatomaceous earth; The fermentation broth and glycerin are added to the water phase pot for homogenization and stirring, so that they are dispersed evenly, and the temperature is kept above 60 °C, and then modified diatomite, safflower extract, juniper fruit extract, ginger oil, wintergreen are added. Oil, peppermint essential oil, rosemary essential oil, heated to 80°C, stirred while heating, kept stirring for 30min, then cooled to 50°C, finally added vanillyl butyl ether, allantoin, and cannabidiol, stirred and mixed evenly, Cool down to 30°C, filter out the material to obtain the desired massage cream to relieve muscle discomfort.

In this embodiment, preferably the preparation method of the Houttuynia cordata fermentation broth is as follows: wash the Houttuynia cordata, drain, seal and freeze for 2 hours in a -10°C freezer, add buffer for homogenization treatment, and obtain fish Xingcao slurry, the buffer is any one of sodium acetate buffer, potassium phosphate buffer, sodium citrate buffer, then adjust the pH to 8, then inoculate the lactobacillus diploid, and seal and ferment it at a constant temperature of 25 ° C for 150 10 minutes, high temperature sterilization and filtering to remove impurities to obtain the Houttuynia cordata fermented liquid.

Preferably, the preparation method of the safflower extract is as follows: the preparation method of the safflower extract is as follows: take safflower, wash, dry, pulverize, put into a percolator, and use 6 times the weight of 10% ethanol aqueous solution Perform percolation extraction to obtain percolation extraction solution and percolation extraction residue, add the percolation extraction residue to 5 times the weight of 15% ethanol aqueous solution, soak for 2h, ultrasonically extract for 20min, filter, and obtain ultrasonic extraction solution and ultrasonic extraction residue. The ultrasonic extraction residue was added with 4 times the weight of water, put into the autoclave, decocted under high pressure for 20min, filtered to obtain the high-pressure extraction solution and the high-pressure extraction residue, combined the percolation extraction solution, the ultrasonic extraction solution and the high-pressure extraction solution, and evaporated under reduced pressure Concentrate to 10% of the original volume to obtain the safflower extract.

Further, preferably the preparation method of the juniper fruit extract is as follows: take the juniper fruit, wash it, dry it, put it into a frying container, heat it with a simmer, fry it until it swells, pulverize and sieve it, and then put the powder in a frying container. The oxidizing lye solution is mixed with a weight ratio of 1:6 and left to stand for 1 hour to form a mixed solution. The oxidizing lye solution is 10% sodium hydroxide and 1% sodium hypochlorite in a weight ratio of 1 The ratio of : 4 was mixed and prepared, and then the mixed solution was put into a microwave reactor with a microwave power of 400w to react for 10 minutes, and then the mixture was taken out and filtered to obtain a filtrate, and the obtained filtrate was concentrated under reduced pressure to obtain a juniper fruit extract.

Preferably, the preparation method of the modified diatomite is as follows: take the diatomite and place it in a muffle furnace to program the temperature to 800°C, calcinate at a constant temperature for 2 hours, and grind to a particle size of 200 mesh after cooling; then add diatomite with a mass of 10 times the water and 0.2 times the mass of diatomite sodium lignosulfonate to form a suspension slurry, add chitosan to the suspension slurry, stir well, and synergize with ultrasonic hydrothermal treatment for 2 hours, and finally centrifuge it. After that, vacuum filtration and spray drying to obtain modified diatomaceous earth.

Example 2

First weigh the following raw materials by weight: 42 parts of water, 22 parts of Houttuynia cordata fermentation broth, 12 parts of glycerin, 3 parts of safflower extract, 2 parts of juniper fruit extract, 1.5 parts of ginger oil, wintergreen oil 2.5 parts, peppermint essential oil 3.5 parts, rosemary essential oil 2.5 parts, vanillyl butyl ether 0.8 parts, allantoin 0.6 parts, cannabidiol 0.3 parts, modified diatomaceous earth 13 parts; The fermentation broth and glycerin are added to the water phase pot for homogenization and stirring, so that they are dispersed evenly, and the temperature is kept above 60 °C, and then modified diatomite, safflower extract, juniper fruit extract, ginger oil, wintergreen are added. Oil, peppermint essential oil, rosemary essential oil, heated to 80°C, stirred while heating, kept stirring for 30min, then cooled to 50°C, finally added vanillyl butyl ether, allantoin, and cannabidiol, stirred and mixed evenly, Cool down to 30°C, filter out the material to obtain the desired massage cream to relieve muscle discomfort.

In this embodiment, preferably the preparation method of the Houttuynia cordata fermentation broth is as follows: wash the Houttuynia cordata, drain, seal and freeze for 2 hours in a -10°C freezer, add buffer for homogenization treatment, and obtain fish Xingcao slurry, the buffer is any one of acetic acid-sodium acetate buffer, potassium phosphate buffer, sodium citrate buffer, then adjust the pH to 8, then inoculate with lactobacillus, and seal fermentation at a constant temperature of 28°C For 160 minutes, filter and remove impurities after high temperature sterilization to obtain the Houttuynia cordata fermentation broth.

Preferably, the preparation method of the safflower extract is as follows: the preparation method of the safflower extract is as follows: take safflower, wash, dry, pulverize, put into a percolator, and use 6 times the weight of 10% ethanol aqueous solution Perform percolation extraction to obtain percolation extraction solution and percolation extraction residue. Add the percolation extraction residue to 5 times the weight of 15% ethanol aqueous solution, soak for 2 hours, ultrasonically extract for 25 minutes, and filter to obtain ultrasonic extraction solution and ultrasonic extraction residue. The ultrasonic extraction residue was added with 4 times the weight of water, put into the autoclave, decocted at high pressure for 22 min, filtered to obtain the high-pressure extraction solution and the high-pressure extraction residue, combined the percolation extraction solution, the ultrasonic extraction solution and the high-pressure extraction solution, and evaporated under reduced pressure Concentrate to 10% of the original volume to obtain the safflower extract.

Further, preferably the preparation method of the juniper fruit extract is as follows: take the juniper fruit, wash it, dry it, put it into a frying container, heat it with a simmer, fry it until it swells, pulverize and sieve it, and then put the powder in a frying container. The oxidizing lye solution is mixed with a weight ratio of 1:6 and left to stand for 1.5 hours to form a mixed solution. The oxidizing lye solution is sodium hydroxide with a concentration of 10% and sodium hypochlorite with a concentration of 1%. The mixture was prepared by mixing in a ratio of 1:4, and then the mixed solution was put into a microwave reactor with a microwave power of 410w to react for 12 minutes, and then the filter residue was taken out and filtered to obtain a filtrate, and the obtained filtrate was concentrated under reduced pressure to obtain a juniper fruit extract. .

Preferably, the preparation method of the modified diatomite is as follows: take the diatomite and place it in a muffle furnace to program the temperature to 825°C, calcinate at a constant temperature for 2 hours, and grind to a particle size of 225 mesh after cooling; then add diatomite with a mass of 10.5 times the water and 0.2 times the mass of diatomite sodium lignosulfonate to form a suspension slurry, add chitosan to the suspension slurry, stir well, and synergize with ultrasonic hydrothermal treatment for 2 hours, and finally centrifuge it. After that, vacuum filtration and spray drying to obtain modified diatomaceous earth.

Example 3

First weigh the following raw materials by weight: 45 parts of water, 25 parts of Houttuynia cordata fermentation broth, 15 parts of glycerin, 4 parts of safflower extract, 3 parts of juniper fruit extract, 2 parts of ginger oil, and wintergreen oil 3 parts, 4 parts of peppermint essential oil, 3 parts of rosemary essential oil, 1 part of vanillyl butyl ether, 0.7 part of allantoin, 0.4 part of cannabidiol, 15 parts of modified diatomaceous earth; The fermentation broth and glycerin are added to the water phase pot for homogenization and stirring, so that they are dispersed evenly, and the temperature is kept above 60 ° C, and then modified diatomite, safflower extract, juniper fruit extract, ginger oil, wintergreen are added. Oil, peppermint essential oil, rosemary essential oil, heated to 80°C, stirred while heating, kept stirring for 30min, then cooled to 50°C, finally added vanillyl butyl ether, allantoin, and cannabidiol, stirred and mixed evenly, Cool down to 30°C, filter out the material to obtain the desired massage cream to relieve muscle discomfort.

In this embodiment, preferably the preparation method of the Houttuynia cordata fermentation broth is as follows: wash the Houttuynia cordata, drain, seal and freeze for 2.5 hours in a -10°C freezer, add buffer for homogenization treatment, and obtain fish Xingcao slurry, the buffer is any one of acetic acid-sodium acetate buffer, potassium phosphate buffer, sodium citrate buffer, then adjust the pH to 8, then inoculate with lactobacillus, and seal fermentation at a constant temperature of 30 ° C For 165 minutes, after high temperature sterilization, filter and remove impurities to obtain the Houttuynia cordata fermentation broth.

Preferably, the preparation method of the safflower extract is as follows: the preparation method of the safflower extract is as follows: take safflower, wash, dry, pulverize, put into a percolator, and use 7 times the weight of 10% ethanol aqueous solution Perform percolation extraction to obtain percolation extraction solution and percolation extraction residue, add percolation extraction residue to 6 times the weight of 15% ethanol aqueous solution, soak for 2.5h, ultrasonically extract for 30min, filter to obtain ultrasonic extraction solution and ultrasonic extraction residue, Add the ultrasonic extraction residue to 5 times the weight of water, put it into the autoclave, decoct at high pressure for 25 minutes, filter to obtain the high-pressure extraction solution and the high-pressure extraction residue, combine the percolation extraction solution, the ultrasonic extraction solution and the high-pressure extraction solution, and reduce the pressure. Evaporate and concentrate to 10% of the original volume to obtain safflower extract.

Further, preferably the preparation method of the juniper fruit extract is as follows: take the juniper fruit, wash it, dry it, put it into a frying container, heat it with a simmer, fry it until it swells, pulverize and sieve it, and then put the powder in a frying container. The oxidizing lye solution is mixed with a weight ratio of 1:7 and left to stand for 2 hours to form a mixed solution. The oxidizing lye solution is 10% sodium hydroxide and 1% sodium hypochlorite in a weight ratio of 1 The ratio of 4.54 was mixed and prepared, and then the mixed solution was put into a microwave reactor with a microwave power of 425w to react for 15min, and then the mixture was taken out and filtered to obtain a filtrate, and the obtained filtrate was concentrated under reduced pressure to obtain a juniper fruit extract.

Preferably, the preparation method of the modified diatomite is as follows: take the diatomite and place it in a muffle furnace to program the temperature to 850°C, calcinate at a constant temperature for 2 hours, and grind to a particle size of 250 mesh after cooling; then add diatomite mass 11 times the water and 0.3 times the mass of diatomite sodium lignosulfonate to form a suspension slurry, add chitosan to the suspension slurry, stir well, and synergize with ultrasonic hydrothermal treatment for 2 hours, and finally centrifuge it. After that, vacuum filtration and spray drying to obtain modified diatomaceous earth.

Example 4

First weigh the following raw materials by weight: 48 parts of water, 28 parts of Houttuynia cordata fermentation broth, 18 parts of glycerin, 5 parts of safflower extract, 4 parts of juniper fruit extract, 2.5 parts of ginger oil, wintergreen oil 3.5 parts, peppermint essential oil 3.4.5 parts, rosemary essential oil 3.5 parts, vanillyl butyl ether 1.2 parts, allantoin 0.8 parts, cannabidiol 0.5 parts, modified diatomaceous earth 17 parts; The fermentation broth and glycerin were added to the water-phase pot for homogenization and stirring, so that they were dispersed evenly, and the temperature was kept above 60 °C, and then modified diatomite, safflower extract, juniper fruit extract, ginger oil were added. , oil of wintergreen, essential oil of peppermint, and essential oil of rosemary, heated to 80 ℃, stirred while heating, kept stirring for 30 minutes, then cooled to 50 ℃, finally added vanillyl butyl ether, allantoin, and cannabidiol, and stirred and mixed Evenly, cool down to 30 ℃, filter out the material to obtain the massage cream that relieves muscle discomfort.

In this embodiment, preferably the preparation method of the Houttuynia cordata fermentation broth is as follows: wash the Houttuynia cordata, drain, seal and freeze for 3 hours in a -10°C freezer, add buffer for homogenization treatment, and obtain fish Xingcao pulp, the buffer is any one of acetic acid-sodium acetate buffer, potassium phosphate buffer, sodium citrate buffer, then adjust the pH to 9, then inoculate with lactobacillus, and ferment at a constant temperature of 33 ° C For 170 minutes, filter and remove impurities after high temperature sterilization to obtain the Houttuynia cordata fermentation broth.

Preferably, the preparation method of the safflower extract is as follows: the preparation method of the safflower extract is as follows: take safflower, wash, air dry, pulverize, put into a percolator, and use 8 times the weight of 10% ethanol aqueous solution Perform percolation extraction to obtain percolation extraction solution and percolation extraction residue. Add the percolation extraction residue to 7 times the weight of 15% ethanol aqueous solution, soak for 3 hours, ultrasonically extract for 35 minutes, and filter to obtain ultrasonic extraction solution and ultrasonic extraction residue. The ultrasonic extraction residue was added with 6 times the weight of water, put into the autoclave, decocted under high pressure for 28 min, filtered to obtain the high-pressure extraction solution and the high-pressure extraction residue, combined the percolation extraction solution, the ultrasonic extraction solution and the high-pressure extraction solution, and evaporated under reduced pressure Concentrate to 10% of the original volume to obtain the safflower extract.

Further, preferably the preparation method of the juniper fruit extract is as follows: take the juniper fruit, wash it, dry it, put it into a frying container, heat it with a simmer, fry it until it swells, pulverize and sieve it, and then put the powder in a frying container. The oxidizing lye solution is mixed with a weight ratio of 1:8 to form a mixed solution after standing for 2.5 hours. The oxidizing lye solution is sodium hydroxide with a concentration of 10% and sodium hypochlorite with a concentration of 1%. The mixture was prepared by mixing in a ratio of 1:5, and then the mixed solution was put into a microwave reactor with a microwave power of 440w to react for 18 minutes, and then the filter residue was taken out and filtered to obtain a filtrate, and the obtained filtrate was concentrated under reduced pressure to obtain a juniper fruit extract. .

Preferably, the preparation method of the modified diatomite is as follows: take the diatomite and place it in a muffle furnace to program the temperature to 875°C, calcinate at a constant temperature for 2 hours, and grind to a particle size of 275 mesh after cooling; then add diatomite mass of 12 times the water and 0.4 times the mass of diatomite sodium lignosulfonate to form a suspension slurry, add chitosan to the suspension slurry, stir well, and synergize with ultrasonic hydrothermal treatment for 2 hours, and finally centrifuge it. After that, vacuum filtration and spray drying to obtain modified diatomaceous earth.

Example 5

First weigh the following raw materials by weight: 50 parts of water, 30 parts of Houttuynia cordata fermentation broth, 20 parts of glycerin, 6 parts of safflower extract, 5 parts of juniper fruit extract, 3 parts of ginger oil, and wintergreen oil 4 parts, 5 parts of peppermint essential oil, 4 parts of rosemary essential oil, 1.5 parts of vanillyl butyl ether, 0.1 part of allantoin, 0.6 part of cannabidiol, 20 parts of modified diatomaceous earth; The fermentation broth and glycerin are added to the water phase pot for homogenization and stirring, so that they are dispersed evenly, and the temperature is kept above 60 °C, and then modified diatomite, safflower extract, juniper fruit extract, ginger oil, wintergreen are added. Oil, peppermint essential oil, rosemary essential oil, heated to 80°C, stirred while heating, kept stirring for 30min, then cooled to 50°C, finally added vanillyl butyl ether, allantoin, and cannabidiol, stirred and mixed evenly, Cool down to 30°C, filter out the material to obtain the desired massage cream to relieve muscle discomfort.

In this embodiment, preferably the preparation method of the Houttuynia cordata fermentation broth is as follows: wash the Houttuynia cordata, drain, seal and freeze for 3 hours in a -10°C freezer, add buffer for homogenization treatment, and obtain fish Xingcao pulp, the buffer is any one of sodium acetate buffer, potassium phosphate buffer, sodium citrate buffer, then adjust the pH to 9, then inoculate the lactobacillus diploid, and seal and ferment it at a constant temperature of 35 ° C for 180 10 minutes, high temperature sterilization and filtering to remove impurities to obtain the Houttuynia cordata fermented liquid.

Preferably, the preparation method of the safflower extract is as follows: the preparation method of the safflower extract is as follows: take safflower, wash, air dry, pulverize, put into a percolator, and use 8 times the weight of 10% ethanol aqueous solution Perform percolation extraction to obtain percolation extraction solution and percolation extraction residue. Add 7 times the weight of percolation extraction residue to 15% ethanol aqueous solution, soak for 3 hours, ultrasonically extract for 40 minutes, and filter to obtain ultrasonic extraction solution and ultrasonic extraction residue. Add 6 times the weight of water to the ultrasonic extraction residue, put it into an autoclave, decoct at high pressure for 30 minutes, filter to obtain a high-pressure extraction solution and a high-pressure extraction residue, combine the percolation extraction solution, the ultrasonic extraction solution and the high-pressure extraction solution, and evaporate under reduced pressure Concentrate to 10% of the original volume to obtain the safflower extract.

Further, preferably the preparation method of the juniper fruit extract is as follows: take the juniper fruit, wash it, dry it, put it into a frying container, heat it with a simmer, fry it until it swells, pulverize and sieve it, and then put the powder in a frying container. The oxidizing lye solution is mixed with a weight ratio of 1:8 and left to stand for 3 hours to form a mixed solution. The oxidizing lye solution is sodium hydroxide with a concentration of 10% and sodium hypochlorite with a concentration of 1% according to the weight ratio of 1 The mixture is prepared by mixing in a ratio of 5:5, then the mixed solution is put into a microwave reactor with a microwave power of 450w to react for 20min, and then the mixture is taken out and filtered to obtain a filtrate, and the obtained filtrate is concentrated under reduced pressure to obtain a juniper fruit extract.

Preferably, the preparation method of the modified diatomite is as follows: take the diatomite and place it in a muffle furnace to program the temperature to 900°C, calcinate at a constant temperature for 2 hours, and grind to a particle size of 300 mesh after cooling; then add diatomite mass 12 times the water and 0.4 times the mass of diatomite sodium lignosulfonate to form a suspension slurry, add chitosan to the suspension slurry, stir well, and synergize with ultrasonic hydrothermal treatment for 2 hours, and finally centrifuge it. After that, vacuum filtration and spray drying to obtain modified diatomaceous earth.

experiment

Control group:

A commercially available massage cream;

Comparative Example 1

On the basis of Example 3, without Houttuynia cordata fermentation broth;

Comparative Example 2

On the basis of Example 3, without cannabidiol;

Comparative Example 3

On the basis of Example 3, without Houttuynia cordata fermentation broth and cannabidiol;

Comparative Example 4

On the basis of Example 3, Houttuynia cordata fermented liquid is replaced with Houttuynia cordata extract;

Comparative Example 5

On the basis of Example 3, the modified diatomaceous earth was replaced with ordinary diatomaceous earth.

Embodiments 1-5, control groups and comparative examples 1-5 were tested:

Test purpose: whether the massage cream can help massage the skin, promote skin metabolism and blood circulation, make the skin breathe smoothly, and get deep nourishment.

Select 1100 long-term standing or long-term sedentary test subjects, aged between 35-55 years old, among them, 100 test subjects are divided into 11 groups, 100 cases in each group, the massage ointment prepared by embodiment 1-5 They were applied to 5 groups of testers respectively. Comparative Examples 1-5 were applied to the other 5 groups of testers. The control group was applied to the last group of testers. After cleansing the skin in the morning and evening, the testers evenly applied the massage cream to the waist and neck. , and then massage for 10 to 15 minutes, once a day for 30 consecutive days;

Result Judgment Criteria:

Effective: The experimenter felt very satisfied, the waist and neck meridians were unblocked, effectively relieved pain, relieved tension and relieved pressure, and the texture density of neck skin was significantly reduced under the microscope;

Significant effect: The experimenter felt generally satisfied with himself, the waist and neck meridians were slightly smooth, the pain was relieved a little, the tension and pressure were relieved a little, and the texture density of the neck skin was slightly reduced under the microscope;

Invalid: the experimenter felt dissatisfied, the waist and neck meridians were not obviously smooth, there was no obvious pain relief, and the feeling of eliminating tension and pressure, and the texture density of the neck skin was not obvious under the microscope.

None of the subjects had allergic or other toxic side effects.

The experimental results are as follows:

组别group	有效efficient	显效effective	无效invalid
实施例1Example 1	8888	66	66
实施例2Example 2	8989	66	55
实施例3Example 3	9292	55	33
实施例4Example 4	8888	77	55
实施例5Example 5	8787	77	66
对比例1Comparative Example 1	7171	1414	1515

对比例2Comparative Example 2	7272	1313	1515
对比例3Comparative Example 3	6161	1515	24twenty four
对比例4Comparative Example 4	7979	1111	1010
对比例5Comparative Example 5	8282	88	1010
对照组control group	2828	3434	4848

It can be seen from the above results that the massage ointment prepared by the present invention has good curative effect, especially cannabidiol and Houttuynia cordata fermented liquid play an important role in improving the efficacy, and cannabidiol and Houttuynia cordata fermented liquid are synergistic In combination, the effect is good, and the modified diatomite can further contribute to the exertion of the medicinal effect.

By adding Houttuynia cordata fermented liquid, it can clear heat and detoxify, reduce swelling and treat sores, and promote blood circulation. By adding safflower extract, it has the functions of treating bruises, swelling and pain, promoting blood circulation, removing blood stasis and relieving pain, and also has the function of fever. , By adding juniper fruit extract, it has the functions of promoting qi, relieving pain, expelling wind and dehumidifying, and can relieve rheumatism joint pain, dermatitis, muscle numbness and pain, and is effective against staphylococcus, streptococcus, dysentery bacillus, Pasteurella, cholera arc Bacteria have strong antibacterial effects. Ginger oil can activate the whole body's mental tissue, make the whole body fever, dispel wind, relieve muscle soreness, as well as sterilize and relieve itching. The main components of peppermint essential oil are antipruritic, analgesic, antiseptic, Stimulating, anesthetizing, cooling and anti-inflammatory effects, wintergreen oil can promote rapid blood circulation in painful areas, relax meridians, relieve pain, rosemary essential oil can be used to treat muscle sprains, very effective in dealing with various muscle problems, cannabidiol , can play a role in soothing muscles and relieving discomfort. Both Houttuynia cordata and cannabidiol synergistically synergize. By adding modified diatomaceous earth, the porous structure has strong adsorption and can absorb a lot of medicinal ingredients, making The effect of the drug is fully exerted, and the effect of the drug lasts longer.

The above are only specific embodiments of the present disclosure, but the protection scope of the present disclosure is not limited to this. should be included within the scope of protection of the present disclosure. Therefore, the protection scope of the present disclosure should be subject to the protection scope of the claims.

Claims

A massage cream for relieving muscle discomfort, comprising the following raw materials by weight: 40-50 parts of water, 20-30 parts of Houttuynia cordata fermented liquid, 10-20 parts of glycerin, 2-6 parts of safflower extract parts, juniper fruit extract 1-5 parts, ginger oil 1-3 parts, wintergreen oil 2-4 parts, peppermint essential oil 3-5 parts, rosemary essential oil 2-4 parts, vanillyl butyl ether 0.5- 1.5 parts, 0.4-1 part of allantoin, 0.2-0.6 part of cannabidiol, and 10-20 parts of modified diatomaceous earth.
The massage cream for relieving muscle discomfort according to claim 1, is characterized in that, comprises the following raw materials according to weight: 42-48 parts of water, 22-28 parts of Houttuynia cordata fermented liquid, 12-18 parts of glycerin, safflower 3-5 parts of extract, 2-4 parts of juniper fruit extract, 1.5-2.5 parts of ginger oil, 2.5-3.5 parts of wintergreen oil, 3.5-4.5 parts of peppermint essential oil, 2.5-3.5 parts of rosemary essential oil, vanillyl 0.8-1.2 parts of butyl ether, 0.6-0.8 parts of allantoin, 0.3-0.5 parts of cannabidiol, and 13-17 parts of modified diatomaceous earth.
The massage ointment for relieving muscle discomfort according to claim 2, characterized in that, comprising the following raw materials by weight: 45 parts of water, 25 parts of Houttuynia cordata fermented liquid, 15 parts of glycerin, 4 parts of safflower extract, thorn 3 parts of cypress fruit extract, 2 parts of ginger oil, 3 parts of wintergreen oil, 4 parts of peppermint essential oil, 3 parts of rosemary essential oil, 1 part of vanillyl butyl ether, 0.7 parts of allantoin, 0.4 parts of cannabidiol, 15 parts of modified diatomaceous earth.
The massage cream for relieving muscle discomfort according to claim 1, wherein the preparation method of the safflower extract is as follows: the preparation method of the safflower extract is as follows: take safflower, wash, dry, pulverize , put it into the percolator, use 6-8 times the weight of 10% ethanol aqueous solution for percolation extraction, obtain percolation extract and percolation extraction residue, add 5-7 times the weight of the percolation extraction residue to 15% ethanol Aqueous solution, soaked for 2-3h, ultrasonically extracted for 20-40min, filtered to obtain ultrasonic extraction solution and ultrasonic extraction residue, add the ultrasonic extraction residue to 4-6 times the weight of water, put it into an autoclave, and cook at high pressure for 20-30min, Filter to obtain high-pressure extraction solution and high-pressure extraction residue, combine percolation extraction solution, ultrasonic extraction solution and high-pressure extraction solution, evaporate under reduced pressure and concentrate to 10% of the original volume to obtain safflower extract.
The massage cream for relieving muscle discomfort according to claim 1, is characterized in that, the preparation method of described juniper fruit extract is as follows: get juniper fruit, wash, dry, put into frying container, heat with slow fire , stir fry until bulging, crush and sieve, then mix the powder in the oxidizing lye solution according to the weight ratio of 1:6-8 and let it stand for 1-3 hours to form a mixed solution, and then put the mixed solution into the microwave with a power of After 10-20min of reaction in a 400-450w microwave reactor, take out and filter the filter residue to obtain a filtrate, and the obtained filtrate is concentrated under reduced pressure to obtain a juniper fruit extract.
The massage ointment for relieving muscle discomfort according to claim 5, wherein the oxidizing lye is a mixture of sodium hydroxide with a concentration of 10% and sodium hypochlorite with a concentration of 1% in a weight ratio of 1:4-5 Proportions are mixed.
The massage cream for relieving muscle discomfort according to any one of claims 1-6, wherein the preparation method steps are as follows:

1) adding water, Houttuynia cordata fermented liquid and glycerin into the water-phase pot for homogeneous stirring, so that they are dispersed evenly, keeping the temperature above 60°C;

2) Then add modified diatomaceous earth, safflower extract, juniper fruit extract, ginger oil, wintergreen oil, peppermint essential oil, rosemary essential oil, heat to 80°C, stir while heating, and keep stirring for 30 minutes. Cool down by 50℃;

3) Finally, add vanillyl butyl ether, allantoin, and cannabidiol, stir and mix evenly, cool down to 30° C., filter and discharge the material to obtain the desired massage cream for relieving muscle discomfort.