WO2022072930A1 - Dispositifs à libération prolongée et agents thérapeutiques pour le traitement à long terme d'une infection des voies urinaires in vivo - Google Patents

Dispositifs à libération prolongée et agents thérapeutiques pour le traitement à long terme d'une infection des voies urinaires in vivo Download PDF

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Publication number
WO2022072930A1
WO2022072930A1 PCT/US2021/053383 US2021053383W WO2022072930A1 WO 2022072930 A1 WO2022072930 A1 WO 2022072930A1 US 2021053383 W US2021053383 W US 2021053383W WO 2022072930 A1 WO2022072930 A1 WO 2022072930A1
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WO
WIPO (PCT)
Prior art keywords
urinary tract
tract infection
vivo
matrix
therapeutic
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Application number
PCT/US2021/053383
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English (en)
Inventor
Dmitri PETRYCHENKO
Original Assignee
Petrychenko Dmitri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Publication of WO2022072930A1 publication Critical patent/WO2022072930A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00—Drainage appliance for wounds or the like, i.e. wound drains, implanted drains
    • A61M27/002—Implant devices for drainage of body fluids from one part of the body to another
    • A61M27/008—Implant devices for drainage of body fluids from one part of the body to another pre-shaped, for use in the urethral or ureteral tract
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/042—Urinary bladders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2002/048—Ureters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/04—General characteristics of the apparatus implanted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/10—Trunk
    • A61M2210/1078—Urinary tract
    • A61M2210/1085—Bladder

Definitions

  • urinary tract infections are often hard to treat since they often respond marginally to oral antibiotics.
  • a urinary tract infection can also spread to the blood stream, causing life-threatening septicemia.
  • urinary tract infections are a major problem since oral antibiotics do not function as a prophylactic to the infection.
  • Economic benefits may also accrue attributable to a reduced need for intravenous antibiotics, hospitalization, and invasive procedures to treat urinary tract infections.
  • the present disclosure is related to extended release therapeutic agents such as antibiotics that can be delivered via a urinary bladder implant, which are activated by inflammatory PH and inflammatory mediators.
  • the implantable device is selected from stents, grafts, stent-grafts, catheters, shunts, closure devices, valves, and particles.
  • biologically degradable or “biodegradable”
  • biologicalcally erodable or “bioerodable”
  • biologicalcally absorbable or “bioabsorbable”
  • biologicalcally resorbable or “bioresorbable”
  • polymers and coatings are used interchangeably and refer to polymers and coatings that are capable of being completely or substantially completely degraded, dissolved, and/or eroded over time when exposed to physiological conditions and can be gradually resorbed, absorbed and/or eliminated by the body, or that can be degraded into fragments that can pass through the kidney membrane of an animal (e.g., a human), e.g., fragments having a molecular weight of about 40,000 Daltons (40 kDa) or less.
  • an animal e.g., a human
  • a "biostable" polymer or coating refers to a polymer or coating that is not biodegradable.
  • “Complete degradation" of a polymer or a polymeric material means that the polymer or the polymeric material loses at least about 95% of its mass over a period of time.
  • substantially complete degradation of a polymer or a polymeric material means that the polymer or the polymeric material loses at least about 75% of its mass over a period of time.
  • substantially complete degradation of a polymer or a polymeric material can mean that the polymer or the polymeric material loses at least about 80% of its mass, or at least about 85% of its mass, or at least about 90% of its mass, or at least about 95% of its mass over a period of time.
  • Physiological conditions refer to conditions to which an implant is exposed within the body of an animal (e.g., a human).
  • Physiological conditions include, but are not limited to, "normal" body temperature for that species of animal (approximately 37° C. for a human) and an aqueous environment of physiologic ionic strength, pH and enzymes.
  • the body temperature of a particular animal may be above or below what would be considered “normal” body temperature for that species of animal.
  • the body temperature of a human may be above or below approximately 37° C. in certain cases.
  • the scope of the present invention encompasses those cases where the physiological conditions (e.g., body temperature) of an animal are not considered "normal”.
  • FIG. 1 shows an embodiment of an implant apparatus.
  • FIG. 2 is a cross-sectional view of the implant apparatus.
  • Embodiments disclosed herein provide devices and methods for a urinary bladder implant apparatus and extended release therapeutics for urinary tract infection.
  • an implant apparatus comprising a container containing a therapeutic agent that has been physically trapped, or covalently or ionically immobilized, in a biodegradable matrix.
  • the therapeutic agents can be physically trapped in the matrix by mixing, ionic bonding on the matrix and/or covalent bonding via irradiation or through the use of cross-linkers including, but not limited to, glutaraldehyde, polyethylene glycol epoxide or ethylene oxide.
  • the biodegradable matrix is in the form of a cylinder.
  • the sides of the cylinder preferably include an impermeable coating.
  • One or both ends of the cylinder can be open to the tissue, or the cylinder ends may be covered with a water-permeable membrane.
  • a biodegradable matrix is a matrix made of materials, usually polymers, which are degradable by enzymatic or acid/base hydrolysis. Once inserted into the body, the matrix is acted upon by enzymes and body fluids. Biodegradation, as used herein, is a process which is different from the process of dissolution. Dissolution occurs as a function of the solute properties of the material. With a dissolving matrix, the therapeutic agent is released as the matrix dissolves. Thus, the length of time the device will release the therapeutic agent is a function of the amount of therapeutic agent within the matrix. For long-term release, the device would have to be quite large to provide a continuous supply of the therapeutic agent. A matrix which is biodegradable only releases the therapeutic agent as the matrix is acted upon by body fluids or enzymes.
  • the biodegradability of the matrix can control the rate of release of the therapeutic agent.
  • the therapeutic agent does not diffuse out of the matrix, but is only released as the matrix is biodegraded.
  • the matrix is biodegradable, there is no residue of the matrix remaining when the entire dose of the therapeutic agent has been delivered. Because there is no residual matrix remaining, there is no need to remove the device.
  • FIG. 1 shows an embodiment of an implant apparatus as shown and described in U.S. Patent 5,629,008, the entirety of which is incorporated by reference herein.
  • the apparatus comprises a cylinder 10 including a wall 20 that is preferably non-permeable to macromolecules such as proteins and cells.
  • the cylinder wall 20 can be made of medical-grade silicone, stainless steel, titanium, gold, or plastics.
  • the cylinder 10 is filled with a biodegradable matrix 30 with a therapeutic admixed therein.
  • the ends 15, 17 of the cylinder 10 are preferably open to the tissue.
  • FIG. 2 is a cross-sectional view of cylinder 10 showing the cylinder wall 20 and the biodegradable matrix 30 therein.
  • the device is preferably between 0.1 cm and 3.0 cm in length and preferably between 0.1 cm and 3.0 cm in diameter. It is to be understood that while a cylinder is the preferred shape of the device that is contemplated as the present invention, the device can be any other shape including, but not limited to, a disc, or a ring.
  • the long-term delivery device can also have a diameter which ranges in size from 20 microns to 3,000 microns and length which can range in size from 20 microns to 3,000 microns.
  • One micron is defined as lx IO -6 meters.
  • the device is between 20 to 200 microns in length and between 20 to 200 microns in diameter.
  • a cylinder is the described shape of the device
  • the device can be any other shape including, but not limited to, a disc, a rectangle or a ring.
  • An embodiment of a disc would have the dimensions of 120 microns in diameter and 120 microns in thickness.
  • An embodiment of a rectangle would be 1.2 mm long, 1.0 mm wide and 1.0 mm thick.
  • An embodiment of a ring would have the dimensions of 1.2 mm outer diameter and 200 microns inner diameter.
  • the biodegradable matrix that is placed inside the cylinder can be a matrix chosen from biocompatible materials such as liposomes, polylactides (polylactic acid), polyglycolide (polymer of glycolic acid), polylactide co-glycolide (co-polymers of lactic acid and glycolic acid) polyanhydrides, poly(ortho)esters, polypeptides, hyaluronic acid, collagen, chondroitin sulfate, carboxylic acids, fatty acids, phospholipids, polysaccharides, nucleic acids, polyamino acids, amino acids such as phenylalanine, tyrosine, isoleucine, polynucleotides, polyvinyl propylene, polyvinylpyrrolidone and silicone.
  • a preferred biodegradable matrix is a matrix of one of either polylactide, poly glycolide, or polylactide co-glycolide (co-polymers of lactic acid and glycolic acid).
  • the therapeutic agents can be any compound that is biologically active and requires long term administration to a tissue or organ for maximum efficacy.
  • Therapeutic agents that can be used in accordance with the present invention include, but are not limited to, extended release antibiotics via the urinary bladder implant that are activated by inflammatory PH and inflammatory mediators.
  • drugs for the treatment of infections include mitomycin, gentamicin, ciprofloxacin, norfloxacin, ofloxacin, methanamine, nitrofurantoin, ampicillin, amoxicillin, nafcillin, trimethoprim, sulfonamides trimethoprimsulfamethoxazole, erythromycin, doxycycline, metronidazole, tetracycline, kanamycin, penicillins, cephalosporins, and aminoglycosides.
  • the kinetics of the therapeutic agent release are optimally at zero order kinetics or near zero order kinetics.
  • the rate of release of the therapeutic agent will vary depending upon the target tissue or organ and on the therapeutic agent or agents being delivered.
  • the rate of release of the therapeutic agent can be controlled by the choice of active ingredients with different solubilities and biodegradable matrix, how the therapeutic agent is physically trapped or chemically immobilized in the biodegradable matrix, by varying the area of the biodegradable matrix exposed to the tissue by adjusting the area of the opening in the container, and/or adjusting the permeability of the walls and/or opening to the therapeutic agent.
  • the extended release extended release therapeutics for urinary tract infection can be delivered using other urinary bladder implants known in the art, for example, in certain embodiments, the implantable device is selected from stents, grafts, stent-grafts, catheters, shunts, closure devices, valves, and particles.
  • Exemplary devices are found, for example, in U.S. Pat. 4,016,251, U.S. Pat. 4,016,251; U.S. Pat. No. 8,343,516; U.S. Pat. Pub. No. 2004/0260272; and U.S. Pat. Pub. No. 2012/0190636, the entirety of each of which is incorporated by reference hereby.
  • the device may be deployed in a minimally invasive procedure, such as by implanting the device through the urethra into the ureter so that the drug delivery portion becomes implanted in the bladder.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

L'invention concerne des dispositifs et des agents thérapeutiques à libération prolongée pour le traitement à long terme in vivo d'une infection des voies urinaires.
PCT/US2021/053383 2020-10-02 2021-10-04 Dispositifs à libération prolongée et agents thérapeutiques pour le traitement à long terme d'une infection des voies urinaires in vivo WO2022072930A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063086738P 2020-10-02 2020-10-02
US63/086,738 2020-10-02

Publications (1)

Publication Number Publication Date
WO2022072930A1 true WO2022072930A1 (fr) 2022-04-07

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PCT/US2021/053383 WO2022072930A1 (fr) 2020-10-02 2021-10-04 Dispositifs à libération prolongée et agents thérapeutiques pour le traitement à long terme d'une infection des voies urinaires in vivo

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WO (1) WO2022072930A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040249441A1 (en) * 2002-02-08 2004-12-09 Miller Kathleen M. Implantable or insertable medical device resistant to microbial growth and biofilm formation
US20080069894A1 (en) * 2005-05-27 2008-03-20 Garfield Royer Bioresorbable polymer matrices and methods of making and using the same
WO2018042367A2 (fr) * 2016-08-31 2018-03-08 Vyome Biosciences Pvt. Ltd. Composés, compositions et procédés associés à des applications antimicrobiennes
US20190343991A1 (en) * 2008-09-08 2019-11-14 Laboratorios Farmacéuticos Rovi, S.A. Multi-layered Device

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450150A (en) * 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
US5629008A (en) * 1992-06-02 1997-05-13 C.R. Bard, Inc. Method and device for long-term delivery of drugs
DE10247689A1 (de) * 2002-10-12 2004-04-22 Martin Rahe Implantat in der Harnblase

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040249441A1 (en) * 2002-02-08 2004-12-09 Miller Kathleen M. Implantable or insertable medical device resistant to microbial growth and biofilm formation
US20080069894A1 (en) * 2005-05-27 2008-03-20 Garfield Royer Bioresorbable polymer matrices and methods of making and using the same
US20190343991A1 (en) * 2008-09-08 2019-11-14 Laboratorios Farmacéuticos Rovi, S.A. Multi-layered Device
WO2018042367A2 (fr) * 2016-08-31 2018-03-08 Vyome Biosciences Pvt. Ltd. Composés, compositions et procédés associés à des applications antimicrobiennes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BRAUNER BERNHARD, SCHUSTER CAROLINE, WIRTH MICHAEL, GABOR FRANZ: "Trimethoprim-Loaded Microspheres Prepared from Low-Molecular-Weight PLGA as a Potential Drug Delivery System for the Treatment of Urinary Tract Infections", ACS OMEGA, ACS PUBLICATIONS, US, vol. 5, no. 15, 21 April 2020 (2020-04-21), US , pages 9013 - 9022, XP055930334, ISSN: 2470-1343, DOI: 10.1021/acsomega.0c00981 *

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